CN110183470A - 吡咯并苯并二氮杂卓 - Google Patents
吡咯并苯并二氮杂卓 Download PDFInfo
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- CN110183470A CN110183470A CN201910395572.7A CN201910395572A CN110183470A CN 110183470 A CN110183470 A CN 110183470A CN 201910395572 A CN201910395572 A CN 201910395572A CN 110183470 A CN110183470 A CN 110183470A
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- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 title abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 90
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 26
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 18
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 17
- 150000002367 halogens Chemical class 0.000 claims abstract description 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 15
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 7
- -1 methoxyl group Chemical group 0.000 claims description 93
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- 125000001424 substituent group Chemical group 0.000 claims description 51
- 108010016626 Dipeptides Proteins 0.000 claims description 30
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 27
- OMRPLUKQNWNZAV-CONSDPRKSA-N (6as)-3-[3-[[(6as)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical group C1=CC(OC)=CC=C1C1=CN2C(=O)C3=CC(OC)=C(OCCCOC=4C(=CC=5C(=O)N6C=C(C[C@H]6C=NC=5C=4)C=4C=CC(N)=CC=4)OC)C=C3N=C[C@@H]2C1 OMRPLUKQNWNZAV-CONSDPRKSA-N 0.000 claims description 16
- 125000003118 aryl group Chemical group 0.000 claims description 16
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- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
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- 2012-10-12 US US14/351,175 patent/US9388187B2/en not_active Expired - Fee Related
- 2012-10-12 CA CA2850264A patent/CA2850264C/en not_active Expired - Fee Related
- 2012-10-12 EP EP12772780.8A patent/EP2751110B1/en not_active Not-in-force
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- 2012-10-12 CN CN201910395572.7A patent/CN110183470A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| EA027386B1 (ru) | 2017-07-31 |
| AU2012322932B2 (en) | 2016-11-10 |
| AU2012322932A1 (en) | 2014-05-29 |
| CN103998449A (zh) | 2014-08-20 |
| BR112014008981A2 (pt) | 2017-05-02 |
| EP2751110A1 (en) | 2014-07-09 |
| CA2850264A1 (en) | 2013-04-18 |
| JP6117801B2 (ja) | 2017-04-19 |
| JP2014528466A (ja) | 2014-10-27 |
| EP2751110B1 (en) | 2017-04-19 |
| EA201490554A1 (ru) | 2015-06-30 |
| WO2013053871A1 (en) | 2013-04-18 |
| CA2850264C (en) | 2019-11-05 |
| US20140234346A1 (en) | 2014-08-21 |
| US9388187B2 (en) | 2016-07-12 |
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