CN110087650A - 新的谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 - Google Patents
新的谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 Download PDFInfo
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- CN110087650A CN110087650A CN201880005216.3A CN201880005216A CN110087650A CN 110087650 A CN110087650 A CN 110087650A CN 201880005216 A CN201880005216 A CN 201880005216A CN 110087650 A CN110087650 A CN 110087650A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Abstract
Description
组 | 顶部肺野 | 中肺野 | 下肺野 |
完整对照 | 0 | 0 | 0 |
病理对照 | 24.06±6.12* | 63.76±5.02* | 82.90±2.88* |
化合物I(3mg/kg) | 11.76±1.48* | 37.09±5.86*· | 35.28±5.81*● |
组 | 组织中染料的浓度,μg/mg |
完整 | 0.029±0.004 |
对照(甲醛-30%) | 0.141±0.015* |
化合物I(6mg/kg) | 0.051±0.016*& |
化合物I(18mg/kg) | 0.022±0.003& |
地塞米松0.6mg/kg | 0.066±0.009*& |
双氯芬酸8mg/kg | 0.112±0.031* |
Claims (15)
Priority Applications (2)
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CN202410228498.0A CN118141806A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
CN202410228530.5A CN118141807A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
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RU2017118350 | 2017-05-26 | ||
RU2017118350A RU2665633C1 (ru) | 2017-05-26 | 2017-05-26 | Новый ингибитор глутаминилциклаз и его применение |
RU2017137615A RU2662559C1 (ru) | 2017-10-27 | 2017-10-27 | Новый ингибитор глутаминилциклаз и его применение для лечения заболеваний легких и дыхательных путей |
RU2017137615 | 2017-10-27 | ||
PCT/RU2018/050058 WO2018217139A1 (ru) | 2017-05-26 | 2018-05-24 | Новые ингибиторы глутаминилциклаз и их применение для лечения различных заболеваний |
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CN202410228530.5A Division CN118141807A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
CN202410228498.0A Division CN118141806A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
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CN110087650A true CN110087650A (zh) | 2019-08-02 |
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CN202410228530.5A Pending CN118141807A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
CN202410228498.0A Pending CN118141806A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
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CN202410228498.0A Pending CN118141806A (zh) | 2017-05-26 | 2018-05-24 | 谷氨酰胺酰基环化酶抑制剂及其在治疗多种疾病中的用途 |
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US (2) | US11845740B2 (zh) |
EP (2) | EP3632433A4 (zh) |
JP (2) | JP7293114B2 (zh) |
KR (3) | KR20200010164A (zh) |
CN (3) | CN110087650B (zh) |
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BR (1) | BR112019012597A2 (zh) |
CA (1) | CA3046196A1 (zh) |
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Cited By (2)
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CN112334464A (zh) * | 2018-05-24 | 2021-02-05 | 过敏制药有限责任公司 | 丙二酸的双酰胺衍生物用于在人和动物中治疗变应性疾病和其他疾病的用途 |
CN114874186A (zh) * | 2022-05-16 | 2022-08-09 | 深圳大学 | 一种谷氨酰胺酰基环化酶同工酶抑制剂及其制备方法与应用 |
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RU2647438C2 (ru) * | 2015-05-27 | 2018-03-15 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
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JP6387401B2 (ja) | 2013-05-28 | 2018-09-05 | ヴィアメット ファーマスーティカルズ(エヌシー),インコーポレイテッド | 殺真菌組成物 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112334464A (zh) * | 2018-05-24 | 2021-02-05 | 过敏制药有限责任公司 | 丙二酸的双酰胺衍生物用于在人和动物中治疗变应性疾病和其他疾病的用途 |
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CN114874186A (zh) * | 2022-05-16 | 2022-08-09 | 深圳大学 | 一种谷氨酰胺酰基环化酶同工酶抑制剂及其制备方法与应用 |
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MX2019006880A (es) | 2019-08-01 |
EP3632433A4 (en) | 2021-03-03 |
CN118141807A (zh) | 2024-06-07 |
BR112019012597A2 (pt) | 2019-11-19 |
US11845740B2 (en) | 2023-12-19 |
AU2018273483A1 (en) | 2019-06-20 |
UA124636C2 (uk) | 2021-10-20 |
IL267077B (en) | 2022-07-01 |
WO2018217139A4 (ru) | 2018-12-20 |
AU2018273483B2 (en) | 2024-06-13 |
CA3046196A1 (en) | 2018-11-29 |
CN118141806A (zh) | 2024-06-07 |
IL267077A (en) | 2019-10-31 |
EP4335509A2 (en) | 2024-03-13 |
US20200087285A1 (en) | 2020-03-19 |
CN110087650B (zh) | 2024-03-22 |
US20240116898A1 (en) | 2024-04-11 |
JP2021533078A (ja) | 2021-12-02 |
WO2018217139A1 (ru) | 2018-11-29 |
KR20200010164A (ko) | 2020-01-30 |
EP4335509A3 (en) | 2024-06-05 |
KR20240035919A (ko) | 2024-03-18 |
JP2023071720A (ja) | 2023-05-23 |
JP7293114B2 (ja) | 2023-06-19 |
KR20240035920A (ko) | 2024-03-18 |
EP3632433A1 (en) | 2020-04-08 |
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