CN1100773C - 苯并呋喃羧酸胺和磺酰胺 - Google Patents

苯并呋喃羧酸胺和磺酰胺 Download PDF

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Publication number
CN1100773C
CN1100773C CN96198844A CN96198844A CN1100773C CN 1100773 C CN1100773 C CN 1100773C CN 96198844 A CN96198844 A CN 96198844A CN 96198844 A CN96198844 A CN 96198844A CN 1100773 C CN1100773 C CN 1100773C
Authority
CN
China
Prior art keywords
methoxy
alkyl
benzofuransulfonamide
group
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96198844A
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English (en)
Chinese (zh)
Other versions
CN1208411A (zh
Inventor
H·J·黛克
C·罗威
J·G·蒙塔纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9524832.4A external-priority patent/GB9524832D0/en
Priority claimed from GBGB9610515.0A external-priority patent/GB9610515D0/en
Priority claimed from GBGB9610712.3A external-priority patent/GB9610712D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of CN1208411A publication Critical patent/CN1208411A/zh
Application granted granted Critical
Publication of CN1100773C publication Critical patent/CN1100773C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96198844A 1995-12-05 1996-12-05 苯并呋喃羧酸胺和磺酰胺 Expired - Fee Related CN1100773C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9524832.4 1995-12-05
GBGB9524832.4A GB9524832D0 (en) 1995-12-05 1995-12-05 Novel compounds
GBGB9610515.0A GB9610515D0 (en) 1996-05-20 1996-05-20 Novel compounds
GB9610515.0 1996-05-20
GBGB9610712.3A GB9610712D0 (en) 1995-12-05 1996-05-22 Novel compounds
GB9610712.3 1996-05-22

Publications (2)

Publication Number Publication Date
CN1208411A CN1208411A (zh) 1999-02-17
CN1100773C true CN1100773C (zh) 2003-02-05

Family

ID=27268015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96198844A Expired - Fee Related CN1100773C (zh) 1995-12-05 1996-12-05 苯并呋喃羧酸胺和磺酰胺

Country Status (16)

Country Link
US (1) US5773467A (enExample)
EP (1) EP0873331B1 (enExample)
JP (1) JP2000501411A (enExample)
KR (1) KR19990071894A (enExample)
CN (1) CN1100773C (enExample)
AT (1) ATE215540T1 (enExample)
AU (1) AU697976B2 (enExample)
BR (1) BR9611897A (enExample)
CA (1) CA2238376C (enExample)
CZ (1) CZ292443B6 (enExample)
DE (1) DE69620458T2 (enExample)
ES (1) ES2172695T3 (enExample)
HU (1) HUP9903797A3 (enExample)
NO (1) NO982570L (enExample)
PL (1) PL327181A1 (enExample)
WO (1) WO1997020833A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ371998A3 (cs) * 1996-05-20 1999-03-17 Darwin Discovery Limited Benzofuranové karboxamidy a jejich terapeutické použití
EP0923568B9 (en) * 1996-08-19 2003-08-13 ALTANA Pharma AG Novel benzofuran-4-carboxamides
JP3268236B2 (ja) 1997-07-22 2002-03-25 シャープ株式会社 電子写真感光体、及びビスヒドラゾン化合物およびその中間体、ならびにそれら化合物の製造方法
ATE237612T1 (de) 1997-10-01 2003-05-15 Kyowa Hakko Kogyo Kk Benzofuranderivate
AU1983599A (en) * 1998-01-26 1999-08-09 Kyowa Hakko Kogyo Co. Ltd. Oxygenic heterocyclic compounds
JP2002502851A (ja) * 1998-02-09 2002-01-29 ダーウィン・ディスカバリー・リミテッド ベンゾフラン−４−カルボキサミドとその治療的使用
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW555759B (en) * 1998-06-08 2003-10-01 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
JP2002517495A (ja) * 1998-06-10 2002-06-18 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ホスホジエステラーゼ４の阻害剤としてのテトラヒドロフラニルオキシ置換基を有するベンズアミド
HRP20020158B1 (en) 1999-08-21 2007-08-31 Altana Pharma Ag Action of synergistic combination
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
GB0011802D0 (en) * 2000-05-16 2000-07-05 Smithkline Beecham Method for enhancing cognitive function
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
FR2903106B1 (fr) * 2006-07-03 2010-07-30 Sanofi Aventis Utilisations de 2-benzoyl-imidazopyridines en therapeutique
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
AR074760A1 (es) * 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012011314A1 (ja) 2010-07-22 2012-01-26 扶桑薬品工業株式会社 ベンゾフラノン化合物およびそれを含む医薬組成物
EP3597186B1 (en) 2015-01-05 2021-12-08 The U.S.A. as represented by the Secretary, Department of Health and Human Services Myc g-quadruplex stabilizing small molecules and their use
CN114149457B (zh) * 2021-11-03 2024-04-12 湖北民族大学 一种苯并[c][1,2]氧杂硼戊环-1(3H)-醇类合物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187387A1 (en) * 1984-12-29 1986-07-16 Kaken Pharmaceutical Co., Ltd. Benzofuran derivative, process for preparing the same and pharmaceutical composition containing the same
EP0685475A1 (en) * 1994-05-31 1995-12-06 Bayer Ag Amino-benzofuryl-and thienyl-derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59508773D1 (de) * 1994-07-22 2000-11-09 Byk Gulden Lomberg Chem Fab Dihydrobenzofurane
CN1163493C (zh) * 1995-05-19 2004-08-25 协和发酵工业株式会社 含氧杂环化合物
CZ371998A3 (cs) * 1996-05-20 1999-03-17 Darwin Discovery Limited Benzofuranové karboxamidy a jejich terapeutické použití

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187387A1 (en) * 1984-12-29 1986-07-16 Kaken Pharmaceutical Co., Ltd. Benzofuran derivative, process for preparing the same and pharmaceutical composition containing the same
EP0685475A1 (en) * 1994-05-31 1995-12-06 Bayer Ag Amino-benzofuryl-and thienyl-derivatives

Also Published As

Publication number Publication date
HUP9903797A3 (en) 2001-08-28
CA2238376A1 (en) 1997-06-12
JP2000501411A (ja) 2000-02-08
AU697976B2 (en) 1998-10-22
CZ292443B6 (cs) 2003-09-17
DE69620458T2 (de) 2002-10-02
DE69620458D1 (de) 2002-05-08
US5773467A (en) 1998-06-30
HUP9903797A2 (hu) 2001-04-28
NO982570L (no) 1998-08-04
CN1208411A (zh) 1999-02-17
ES2172695T3 (es) 2002-10-01
MX9804466A (es) 1998-12-31
KR19990071894A (ko) 1999-09-27
NO982570D0 (no) 1998-06-04
EP0873331B1 (en) 2002-04-03
CA2238376C (en) 2006-08-15
CZ171498A3 (cs) 1998-10-14
AU1038697A (en) 1997-06-27
PL327181A1 (en) 1998-11-23
WO1997020833A1 (en) 1997-06-12
BR9611897A (pt) 1999-12-28
EP0873331A1 (en) 1998-10-28
ATE215540T1 (de) 2002-04-15

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee