ES2172695T3 - Carboxamidas y sulfonamidas de benzofurano. - Google Patents

Carboxamidas y sulfonamidas de benzofurano.

Info

Publication number
ES2172695T3
ES2172695T3 ES96941138T ES96941138T ES2172695T3 ES 2172695 T3 ES2172695 T3 ES 2172695T3 ES 96941138 T ES96941138 T ES 96941138T ES 96941138 T ES96941138 T ES 96941138T ES 2172695 T3 ES2172695 T3 ES 2172695T3
Authority
ES
Spain
Prior art keywords
sulfonamids
carboxamids
benzofuran
phosphodesterases
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96941138T
Other languages
English (en)
Inventor
Hazel Joan Dyke
Hannah Jayne Kendall
Christopher Lowe
John Gary Montana
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Darwin Discovery Ltd
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9524832.4A external-priority patent/GB9524832D0/en
Priority claimed from GBGB9610515.0A external-priority patent/GB9610515D0/en
Priority claimed from GBGB9610712.3A external-priority patent/GB9610712D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ES2172695T3 publication Critical patent/ES2172695T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A CARBOXAMIDAS Y SULFONAMIDAS DE BENZOFURANO QUE PRESENTAN UTILIDAD TERAPEUTICA, P.EJ. EN EL TRATAMIENTO DE LA INFLAMACION Y DEL ASMA, DEBIDO A SU CAPACIDAD PARA INHIBIR LAS FOSFODIESTERASAS Y EL FACTOR DE NECROSIS TUMORAL.
ES96941138T 1995-12-05 1996-12-05 Carboxamidas y sulfonamidas de benzofurano. Expired - Lifetime ES2172695T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9524832.4A GB9524832D0 (en) 1995-12-05 1995-12-05 Novel compounds
GBGB9610515.0A GB9610515D0 (en) 1996-05-20 1996-05-20 Novel compounds
GBGB9610712.3A GB9610712D0 (en) 1995-12-05 1996-05-22 Novel compounds

Publications (1)

Publication Number Publication Date
ES2172695T3 true ES2172695T3 (es) 2002-10-01

Family

ID=27268015

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96941138T Expired - Lifetime ES2172695T3 (es) 1995-12-05 1996-12-05 Carboxamidas y sulfonamidas de benzofurano.

Country Status (16)

Country Link
US (1) US5773467A (es)
EP (1) EP0873331B1 (es)
JP (1) JP2000501411A (es)
KR (1) KR19990071894A (es)
CN (1) CN1100773C (es)
AT (1) ATE215540T1 (es)
AU (1) AU697976B2 (es)
BR (1) BR9611897A (es)
CA (1) CA2238376C (es)
CZ (1) CZ292443B6 (es)
DE (1) DE69620458T2 (es)
ES (1) ES2172695T3 (es)
HU (1) HUP9903797A3 (es)
NO (1) NO982570L (es)
PL (1) PL327181A1 (es)
WO (1) WO1997020833A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2162467C2 (ru) * 1996-05-20 2001-01-27 Дарвин Дискавери Лимитед Карбоксамиды бензофурана и их фармацевтическая композиция
DE69717827T2 (de) * 1996-08-19 2003-09-04 Altana Pharma Ag Benzofuran-4-carboxamide
ATE237612T1 (de) * 1997-10-01 2003-05-15 Kyowa Hakko Kogyo Kk Benzofuranderivate
WO1999037640A1 (fr) * 1998-01-26 1999-07-29 Kyowa Hakko Kogyo Co., Ltd. Composes heterocycliques oxygenes
WO1999040085A1 (en) * 1998-02-09 1999-08-12 Darwin Discovery Limited Benzofuran-4-carboxamides and their therapeutic use
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW555759B (en) * 1998-06-08 2003-10-01 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
JP2002517495A (ja) * 1998-06-10 2002-06-18 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ホスホジエステラーゼ４の阻害剤としてのテトラヒドロフラニルオキシ置換基を有するベンズアミド
DE60043318D1 (de) 1999-08-21 2010-01-14 Nycomed Gmbh Synergistische kombination von pumafentrine und salmeterol
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
GB0011802D0 (en) * 2000-05-16 2000-07-05 Smithkline Beecham Method for enhancing cognitive function
FR2903106B1 (fr) * 2006-07-03 2010-07-30 Sanofi Aventis Utilisations de 2-benzoyl-imidazopyridines en therapeutique
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
AR074760A1 (es) * 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
CN103003270B (zh) 2010-07-22 2014-11-12 扶桑药品工业株式会社 苯并呋喃酮化合物以及含有该化合物的药物组合物
EP3242661B1 (en) 2015-01-05 2019-08-21 The U.S.A. as represented by the Secretary, Department of Health and Human Services Myc g-quadruplex stabilizing small molecules and their use
CN114149457B (zh) * 2021-11-03 2024-04-12 湖北民族大学 一种苯并[c][1,2]氧杂硼戊环-1(3H)-醇类合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8705871A1 (es) * 1984-12-29 1987-05-16 Kaken Pharma Co Ltd Un procedimiento para preparar un derivado de benzofurano
DE69507197T2 (de) * 1994-05-31 1999-05-27 Bayer Ag, 51373 Leverkusen Aminobenzofuryl- und -thienylderivate
ATE196765T1 (de) * 1994-07-22 2000-10-15 Byk Gulden Lomberg Chem Fab Dihydrobenzofurane
AU705690B2 (en) * 1995-05-19 1999-05-27 Kyowa Hakko Kogyo Co. Ltd. Oxygen-containing heterocyclic compounds
RU2162467C2 (ru) * 1996-05-20 2001-01-27 Дарвин Дискавери Лимитед Карбоксамиды бензофурана и их фармацевтическая композиция

Also Published As

Publication number Publication date
HUP9903797A2 (hu) 2001-04-28
CN1208411A (zh) 1999-02-17
HUP9903797A3 (en) 2001-08-28
BR9611897A (pt) 1999-12-28
CZ292443B6 (cs) 2003-09-17
NO982570D0 (no) 1998-06-04
DE69620458D1 (de) 2002-05-08
CA2238376C (en) 2006-08-15
WO1997020833A1 (en) 1997-06-12
US5773467A (en) 1998-06-30
PL327181A1 (en) 1998-11-23
CN1100773C (zh) 2003-02-05
EP0873331A1 (en) 1998-10-28
KR19990071894A (ko) 1999-09-27
AU1038697A (en) 1997-06-27
AU697976B2 (en) 1998-10-22
CZ171498A3 (cs) 1998-10-14
MX9804466A (es) 1998-12-31
JP2000501411A (ja) 2000-02-08
EP0873331B1 (en) 2002-04-03
DE69620458T2 (de) 2002-10-02
CA2238376A1 (en) 1997-06-12
ATE215540T1 (de) 2002-04-15
NO982570L (no) 1998-08-04

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