CN110051823A - 高纯度和优异产量的正确折叠的依那西普 - Google Patents

高纯度和优异产量的正确折叠的依那西普 Download PDF

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Publication number
CN110051823A
CN110051823A CN201811633164.2A CN201811633164A CN110051823A CN 110051823 A CN110051823 A CN 110051823A CN 201811633164 A CN201811633164 A CN 201811633164A CN 110051823 A CN110051823 A CN 110051823A
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CN
China
Prior art keywords
etanercept
protein
pharmaceutically acceptable
arginine
capto
Prior art date
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Pending
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CN201811633164.2A
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English (en)
Chinese (zh)
Inventor
荒川力
道格拉斯·法勒
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Ke Rongsheng Biological Science Co Ltd
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Ke Rongsheng Biological Science Co Ltd
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Application filed by Ke Rongsheng Biological Science Co Ltd filed Critical Ke Rongsheng Biological Science Co Ltd
Publication of CN110051823A publication Critical patent/CN110051823A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201811633164.2A 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普 Pending CN110051823A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261699552P 2012-09-11 2012-09-11
US61/699,552 2012-09-11
CN201380058650.5A CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

Related Parent Applications (1)

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CN201380058650.5A Division CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

Publications (1)

Publication Number Publication Date
CN110051823A true CN110051823A (zh) 2019-07-26

Family

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CN201811633164.2A Pending CN110051823A (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普
CN201380058650.5A Expired - Fee Related CN104902914B (zh) 2012-09-11 2013-09-10 高纯度和优异产量的正确折叠的依那西普

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DO (1) DOP2015000055A (enExample)
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HR (1) HRP20180182T1 (enExample)
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LT (1) LT2895188T (enExample)
MX (2) MX360044B (enExample)
NO (1) NO2972131T3 (enExample)
PE (2) PE20150996A1 (enExample)
PL (1) PL2895188T3 (enExample)
PT (1) PT2895188T (enExample)
RS (1) RS57013B1 (enExample)
SG (1) SG11201501460RA (enExample)
SI (1) SI2895188T1 (enExample)
SM (1) SMT201800163T1 (enExample)
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TW201425331A (zh) 2014-07-01
IL237311B (en) 2019-07-31
EA201590542A1 (ru) 2015-07-30
TWI609877B (zh) 2018-01-01
US20140072560A1 (en) 2014-03-13
ECSP15014138A (es) 2016-01-29
MX2015003090A (es) 2015-07-14
BR112015005161A2 (pt) 2017-07-04
RS57013B1 (sr) 2018-05-31
PT2895188T (pt) 2018-02-08
SG11201501460RA (en) 2015-04-29
SMT201800163T1 (it) 2018-05-02
IN2015KN00452A (enExample) 2015-07-17
PL2895188T3 (pl) 2018-06-29
AU2013315750A1 (en) 2015-03-05
TW201803593A (zh) 2018-02-01
AU2013315750B2 (en) 2018-07-12
AU2018247244A1 (en) 2018-11-01
US20190300601A1 (en) 2019-10-03
US20190300602A1 (en) 2019-10-03
CO7400876A2 (es) 2015-09-30
US20190300600A1 (en) 2019-10-03
EP2895188A4 (en) 2016-05-25
WO2014043103A1 (en) 2014-03-20
PE20200607A1 (es) 2020-03-10
US20180037642A1 (en) 2018-02-08
JP6913066B2 (ja) 2021-08-04
IL237311A0 (en) 2015-04-30
KR20200085937A (ko) 2020-07-15
EP2895188A1 (en) 2015-07-22
DK2895188T3 (en) 2018-02-26
MX2018012749A (es) 2020-11-12
JP2021100929A (ja) 2021-07-08
KR102133699B1 (ko) 2020-07-14
US20190330325A1 (en) 2019-10-31
JP2015533797A (ja) 2015-11-26
PE20150996A1 (es) 2015-08-01
US10954295B2 (en) 2021-03-23
EP2895188B1 (en) 2017-11-15
AU2013315750B9 (en) 2018-11-15
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