CN1099798A - 甲型肝炎病毒疫苗 - Google Patents

甲型肝炎病毒疫苗 Download PDF

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Publication number
CN1099798A
CN1099798A CN93117633A CN93117633A CN1099798A CN 1099798 A CN1099798 A CN 1099798A CN 93117633 A CN93117633 A CN 93117633A CN 93117633 A CN93117633 A CN 93117633A CN 1099798 A CN1099798 A CN 1099798A
Authority
CN
China
Prior art keywords
virus
hav
hepatitis
cell
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93117633A
Other languages
English (en)
Chinese (zh)
Inventor
R·A·阿布德
B·C·布克兰
A·J·海根
B·曾克
J·G·欧宁斯
P·A·迪菲利斯
小·J·P·亨尼赛
J·A·路易斯
C·N·奥利弗
C·J·奥雷拉
R·D·西特林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DZ930089A priority Critical patent/DZ1706A1/fr
Priority to PL93307402A priority patent/PL307402A1/xx
Priority to CA002103515A priority patent/CA2103515A1/en
Priority to HU9500417A priority patent/HUT70982A/hu
Priority to ZA935723A priority patent/ZA935723B/xx
Priority to SK184-95A priority patent/SK18495A3/sk
Priority to EP93306223A priority patent/EP0583142A2/en
Priority to MX9304803A priority patent/MX9304803A/es
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to PCT/US1993/007431 priority patent/WO1994003589A2/en
Priority to SI9300421A priority patent/SI9300421A/sl
Priority to AU44500/93A priority patent/AU4450093A/en
Priority to JP21523993A priority patent/JPH0748277A/ja
Priority to FI950567A priority patent/FI950567A7/fi
Priority to CN93117633A priority patent/CN1099798A/zh
Priority to CZ95347A priority patent/CZ34795A3/cs
Priority to NO950483A priority patent/NO950483L/no
Publication of CN1099798A publication Critical patent/CN1099798A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32451—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN93117633A 1992-08-07 1993-08-06 甲型肝炎病毒疫苗 Pending CN1099798A (zh)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DZ930089A DZ1706A1 (fr) 1992-08-07 1993-08-04 Vaccin contre le virus de l'hepatite a.
PCT/US1993/007431 WO1994003589A2 (en) 1992-08-07 1993-08-06 Hepatitis a virus vaccine
HU9500417A HUT70982A (en) 1992-08-07 1993-08-06 Hepatitis a vaccine
ZA935723A ZA935723B (en) 1992-08-07 1993-08-06 Hepatitis A virus vaccine.
SK184-95A SK18495A3 (en) 1992-08-07 1993-08-06 Method of production of hepatitis a virus, purificated virus and vaccine against hepatitis a virus
EP93306223A EP0583142A2 (en) 1992-08-07 1993-08-06 Hepatitis A virus vaccine
MX9304803A MX9304803A (es) 1992-08-07 1993-08-06 Vacuna de virus de hepatitis a.
PL93307402A PL307402A1 (en) 1992-08-07 1993-08-06 Vaccine containing a hepatitis a virus
SI9300421A SI9300421A (en) 1992-08-07 1993-08-06 Hepatitis a virus vaccine
AU44500/93A AU4450093A (en) 1992-08-07 1993-08-06 Hepatitis A virus vaccine
CA002103515A CA2103515A1 (en) 1992-08-07 1993-08-06 Hepatitis a virus vaccine
JP21523993A JPH0748277A (ja) 1992-08-07 1993-08-06 Ａ型肝炎ウィルスワクチン
FI950567A FI950567A7 (fi) 1992-08-07 1993-08-06 Hepatitis A-virusrokote
CN93117633A CN1099798A (zh) 1992-08-07 1993-08-06 甲型肝炎病毒疫苗
CZ95347A CZ34795A3 (en) 1992-08-07 1993-08-06 Process for preparing a hepatitis virus, purified virus and vaccine against a hepatitis virus
NO950483A NO950483L (no) 1992-08-07 1995-02-09 Vaksine mot hepatitt-A

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92687392A 1992-08-07 1992-08-07
CN93117633A CN1099798A (zh) 1992-08-07 1993-08-06 甲型肝炎病毒疫苗

Publications (1)

Publication Number Publication Date
CN1099798A true CN1099798A (zh) 1995-03-08

Family

ID=36869970

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93117633A Pending CN1099798A (zh) 1992-08-07 1993-08-06 甲型肝炎病毒疫苗

Country Status (16)

Country Link
EP (1) EP0583142A2 (enExample)
JP (1) JPH0748277A (enExample)
CN (1) CN1099798A (enExample)
AU (1) AU4450093A (enExample)
CA (1) CA2103515A1 (enExample)
CZ (1) CZ34795A3 (enExample)
DZ (1) DZ1706A1 (enExample)
FI (1) FI950567A7 (enExample)
HU (1) HUT70982A (enExample)
MX (1) MX9304803A (enExample)
NO (1) NO950483L (enExample)
PL (1) PL307402A1 (enExample)
SI (1) SI9300421A (enExample)
SK (1) SK18495A3 (enExample)
WO (1) WO1994003589A2 (enExample)
ZA (1) ZA935723B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101816786A (zh) * 2010-04-30 2010-09-01 长春生物制品研究所 一种甲型肝炎灭活疫苗及其制备方法
CN102058882A (zh) * 2010-12-28 2011-05-18 北京民海生物科技有限公司 一种制备甲型肝炎灭活疫苗的方法
CN106367402A (zh) * 2015-07-23 2017-02-01 基立福有限公司 用于纯化体外产生的病毒的方法及对于病毒的清除测定

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI932248L (fi) * 1991-09-18 1993-07-02 Amgen Inc Hepatit b-vaccinkomposition innehaollande ett gallsyrasalt
HRP950097A2 (en) 1994-03-08 1997-06-30 Merck & Co Inc Hepatitis a virus culture process
TW570803B (en) * 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
JP2001519175A (ja) * 1997-10-09 2001-10-23 プロ − バイラス，インコーポレイテッド ウイルスを用いた新生物の処置
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
HUP0302278A3 (en) 1999-04-15 2011-01-28 Pro Virus Treatment of neoplasms with viruses
KR100421386B1 (ko) * 2001-09-22 2004-03-09 엘지전자 주식회사 초고속용 유도 전동기의 회전자
US6825027B2 (en) 2001-12-10 2004-11-30 Baxter Healthcare S.A. Method of production of purified hepatitis a virus particles and vaccine preparation
AU2003229159B2 (en) 2002-04-30 2008-02-21 Oncolytics Biotech Inc. Improved viral purification methods
GB0304799D0 (en) * 2003-03-03 2003-04-09 Glaxosmithkline Biolog Sa Novel method
EP1709162A2 (en) * 2004-01-27 2006-10-11 Bharat Biotech International Limited A novel process of hepatitis a vaccine preparation
US7901921B2 (en) 2004-10-22 2011-03-08 Oncolytics Biotech Inc. Viral purification methods
CN103013933B (zh) * 2012-12-14 2014-10-22 北京民海生物科技有限公司 人二倍体狂犬病疫苗病毒液的灭活方法
SG11202003793WA (en) 2017-10-30 2020-05-28 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
EP3695849A1 (en) * 2019-02-13 2020-08-19 Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH Method for extracting hepatitis a virus (hav) antigen from cell culture
CN112202628B (zh) * 2020-09-08 2022-09-02 杭州涂鸦信息技术有限公司 一种WiFi模块串口协议自动化测试系统及方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296204A (en) * 1978-01-25 1981-10-20 Merck & Co., Inc. Use of motionless mixer as cell culture propagator
US4164566A (en) 1978-08-17 1979-08-14 Merck & Co., Inc. Hepatitis a virus cell culture in vitro
US5021348A (en) 1979-09-04 1991-06-04 Merck & Co., Inc. Attenuated hepatitis A virus
US4415670A (en) 1980-07-07 1983-11-15 Merck & Co., Inc. Motionless mixer as cell culture propagator
US4301249A (en) * 1980-07-23 1981-11-17 Merck & Co., Inc. High titer production of hepatitis A virus
NZ225583A (en) 1987-08-06 1991-07-26 Merck & Co Inc Process for purifying hepatitis a virions (hav)
JPH0751513B2 (ja) * 1988-04-28 1995-06-05 国立予防衛生研究所長 Ａ型肝炎ワクチン
CA2047041A1 (en) * 1990-07-18 1992-01-19 John A. Lewis Process for purification of hepatitis-a virus capsids

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101816786A (zh) * 2010-04-30 2010-09-01 长春生物制品研究所 一种甲型肝炎灭活疫苗及其制备方法
CN101816786B (zh) * 2010-04-30 2012-09-05 长春生物制品研究所有限责任公司 一种甲型肝炎灭活疫苗及其制备方法
CN102058882A (zh) * 2010-12-28 2011-05-18 北京民海生物科技有限公司 一种制备甲型肝炎灭活疫苗的方法
CN102058882B (zh) * 2010-12-28 2012-12-26 深圳康泰生物制品股份有限公司 一种制备甲型肝炎灭活疫苗的方法
CN106367402A (zh) * 2015-07-23 2017-02-01 基立福有限公司 用于纯化体外产生的病毒的方法及对于病毒的清除测定
CN106367402B (zh) * 2015-07-23 2022-03-08 基立福有限公司 用于纯化体外产生的病毒的方法及对于病毒的清除测定

Also Published As

Publication number Publication date
HU9500417D0 (en) 1995-04-28
NO950483L (no) 1995-04-07
WO1994003589A2 (en) 1994-02-17
WO1994003589A3 (en) 1994-03-31
MX9304803A (es) 1994-05-31
AU4450093A (en) 1994-02-10
CZ34795A3 (en) 1996-03-13
PL307402A1 (en) 1995-05-15
ZA935723B (en) 1995-03-22
EP0583142A2 (en) 1994-02-16
CA2103515A1 (en) 1994-02-11
SI9300421A (en) 1994-06-30
JPH0748277A (ja) 1995-02-21
DZ1706A1 (fr) 2002-02-17
EP0583142A3 (enExample) 1994-04-13
HUT70982A (en) 1995-11-28
FI950567A7 (fi) 1995-04-05
FI950567A0 (fi) 1995-02-09
SK18495A3 (en) 1995-11-08
NO950483D0 (no) 1995-02-09

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WD01 Invention patent application deemed withdrawn after publication