CN1094931C - 抗血栓有机硝酸酯 - Google Patents

抗血栓有机硝酸酯 Download PDF

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Publication number
CN1094931C
CN1094931C CN97181245A CN97181245A CN1094931C CN 1094931 C CN1094931 C CN 1094931C CN 97181245 A CN97181245 A CN 97181245A CN 97181245 A CN97181245 A CN 97181245A CN 1094931 C CN1094931 C CN 1094931C
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CN
China
Prior art keywords
group
compound
integer
definition
free valency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97181245A
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English (en)
Chinese (zh)
Other versions
CN1242768A (zh
Inventor
P·德索尔达托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of CN1242768A publication Critical patent/CN1242768A/zh
Application granted granted Critical
Publication of CN1094931C publication Critical patent/CN1094931C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
CN97181245A 1996-11-14 1997-11-12 抗血栓有机硝酸酯 Expired - Fee Related CN1094931C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
ITMI96A002368 1996-11-14

Publications (2)

Publication Number Publication Date
CN1242768A CN1242768A (zh) 2000-01-26
CN1094931C true CN1094931C (zh) 2002-11-27

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97181245A Expired - Fee Related CN1094931C (zh) 1996-11-14 1997-11-12 抗血栓有机硝酸酯

Country Status (18)

Country Link
US (1) US6242432B1 (enExample)
EP (1) EP0941218B1 (enExample)
JP (1) JP4264137B2 (enExample)
KR (1) KR100504122B1 (enExample)
CN (1) CN1094931C (enExample)
AT (1) ATE226199T1 (enExample)
AU (1) AU729423B2 (enExample)
BR (1) BR9712959B1 (enExample)
CA (1) CA2272063C (enExample)
DE (1) DE69716461T2 (enExample)
DK (1) DK0941218T3 (enExample)
ES (1) ES2186013T3 (enExample)
HU (1) HUP0000667A3 (enExample)
IL (1) IL129768A (enExample)
IT (1) IT1295694B1 (enExample)
PT (1) PT941218E (enExample)
RU (1) RU2190594C2 (enExample)
WO (1) WO1998021193A1 (enExample)

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GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IE20000052A1 (en) * 1999-04-29 2000-11-29 Russinsky Ltd Nitric acid salts of B-blockers
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
WO2001017528A1 (en) 1999-09-08 2001-03-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
JP2003514020A (ja) 1999-10-29 2003-04-15 ニトロメド インコーポレーテッド 酸化窒素不足により特徴付けられる血管疾患の治療法
WO2002034303A1 (en) * 2000-10-27 2002-05-02 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
CN100486573C (zh) * 1999-12-23 2009-05-13 硝化医药股份有限公司 硝基化的和亚硝基化的环加氧酶-2抑制剂、组合物及其用途
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
JP2004501143A (ja) 2000-06-22 2004-01-15 ニトロメド　インコーポレーテッド ニトロソ化およびニトロシル化タキサン、組成物および使用方法
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
CA2475209A1 (en) * 2002-02-04 2003-08-14 Alfama - Investigacao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US7220749B2 (en) * 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
WO2004047837A2 (en) * 2002-11-22 2004-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-blockers having antioxidant and nitric oxide-donor activity
US20060166894A1 (en) * 2002-11-29 2006-07-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
ES2322263T3 (es) * 2003-06-19 2009-06-18 Nicox S.A. Mitroxiderivados de enalapril y compuestos relacionados con inhibidores de ace, para el tratamiento de enfermedades cardiovasculares.
WO2005018561A2 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
AP2006003622A0 (en) * 2003-12-02 2006-06-30 Nicox Sa Nitrooxyderivatives of antihypertensive drugs
WO2005053685A1 (en) * 2003-12-02 2005-06-16 Nicox S.A. Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs
KR100854838B1 (ko) * 2004-01-05 2008-08-29 니콕스 에스. 에이. 프로스타글란딘 나이트로옥시 유도체
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS ASSOCIATED WITH HEART FAILURE
CN101010323B (zh) * 2004-08-25 2010-06-16 埃科特莱茵药品有限公司 作为肾素抑制剂的双环壬烯衍生物
WO2006052899A2 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders
AU2006206249A1 (en) * 2005-01-21 2006-07-27 Nicox S.A. Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
US20080274171A1 (en) * 2005-10-18 2008-11-06 Nicoletta Almirante Renin Inhibitors Nitroderivatives
WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
NZ570828A (en) 2006-02-02 2011-07-29 Actelion Pharmaceuticals Ltd Secondary amines as renin inhibitors
AU2007217980A1 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
WO2007102127A2 (en) * 2006-03-08 2007-09-13 Actelion Pharmaceuticals Ltd New amines
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
CA2652135A1 (en) * 2006-05-16 2007-11-29 Nitromed, Inc. Solid dosage formulations of hydralazine compounds
RU2322972C1 (ru) * 2006-09-12 2008-04-27 Илья Николаевич Медведев Способ профилактики тромбозов у больных артериальной гипертонией с метаболическим синдромом
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
FR2921365B1 (fr) * 2007-09-21 2012-10-12 Servier Lab Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MX2010012067A (es) * 2008-05-05 2010-12-06 Merck Frosst Canada Ltd Derivados de 3,4-piperidina sustituida como inhibidores de la renina.
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
WO2012145520A2 (en) 2011-04-19 2012-10-26 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
JP7055802B2 (ja) 2016-11-08 2022-04-18 ボシュ・アンド・ロム・インコーポレイテッド 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体
CA3145453A1 (en) 2019-07-01 2021-01-07 Tonix Pharma Limited Anti-cd154 antibodies and uses thereof
JP2024503625A (ja) 2021-01-06 2024-01-26 トニックス ファーマ リミテッド 改変された抗ｃｄ１５４抗体により免疫寛容を誘導する方法
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0637583A1 (en) * 1993-07-30 1995-02-08 Prodesfarma, S.A. 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities

Family Cites Families (4)

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IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
AU678063B2 (en) 1993-10-06 1997-05-15 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1997031896A1 (en) * 1996-03-01 1997-09-04 Sankyo Company, Limited Thiazolidine derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0637583A1 (en) * 1993-07-30 1995-02-08 Prodesfarma, S.A. 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities

Also Published As

Publication number Publication date
BR9712959A (pt) 2000-02-01
EP0941218A1 (en) 1999-09-15
ITMI962368A1 (it) 1998-05-14
ITMI962368A0 (it) 1996-11-14
BR9712959B1 (pt) 2010-06-01
KR100504122B1 (ko) 2005-07-27
IT1295694B1 (it) 1999-05-27
CA2272063A1 (en) 1998-05-22
JP4264137B2 (ja) 2009-05-13
ES2186013T3 (es) 2003-05-01
AU729423B2 (en) 2001-02-01
PT941218E (pt) 2003-03-31
DE69716461D1 (de) 2002-11-21
IL129768A (en) 2004-02-19
JP2001507676A (ja) 2001-06-12
CA2272063C (en) 2008-05-27
KR20000053251A (ko) 2000-08-25
US6242432B1 (en) 2001-06-05
AU5551998A (en) 1998-06-03
DK0941218T3 (da) 2003-02-17
ATE226199T1 (de) 2002-11-15
HUP0000667A3 (en) 2000-08-28
EP0941218B1 (en) 2002-10-16
DE69716461T2 (de) 2003-06-26
IL129768A0 (en) 2000-02-29
RU2190594C2 (ru) 2002-10-10
CN1242768A (zh) 2000-01-26
HUP0000667A2 (en) 2000-07-28
WO1998021193A1 (en) 1998-05-22

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C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20021127

Termination date: 20111112