ES2186013T3 - Nitratos organicos con actividad antitrombotica. - Google Patents

Nitratos organicos con actividad antitrombotica.

Info

Publication number
ES2186013T3
ES2186013T3 ES97951890T ES97951890T ES2186013T3 ES 2186013 T3 ES2186013 T3 ES 2186013T3 ES 97951890 T ES97951890 T ES 97951890T ES 97951890 T ES97951890 T ES 97951890T ES 2186013 T3 ES2186013 T3 ES 2186013T3
Authority
ES
Spain
Prior art keywords
antitrombotic
activity
organic nitrates
preferibly
timolol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951890T
Other languages
English (en)
Inventor
Soldato Piero Del
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Application granted granted Critical
Publication of ES2186013T3 publication Critical patent/ES2186013T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS, O A SUS COMPOSICIONES, DE FORMULA GENERAL: A - (X 1 - NO 2 ) TO O A SUS SALES, PARA LA PREPARACION DE MEDICAMENTOS PARA APLICACION ANTITROMBOTICA, DONDE: TO ES UN ENTERO IGUAL A 1 O 2; X 1 ES UN PUENTE DE CONEXION DE ALQUILENO; A ES EL RESIDUO DE PRODUCTOS CARDIOVASCULARES, PREFERIBLEMENTE TIMOLOL O ENALAPRIL.
ES97951890T 1996-11-14 1997-11-12 Nitratos organicos con actividad antitrombotica. Expired - Lifetime ES2186013T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Publications (1)

Publication Number Publication Date
ES2186013T3 true ES2186013T3 (es) 2003-05-01

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951890T Expired - Lifetime ES2186013T3 (es) 1996-11-14 1997-11-12 Nitratos organicos con actividad antitrombotica.

Country Status (18)

Country Link
US (1) US6242432B1 (es)
EP (1) EP0941218B1 (es)
JP (1) JP4264137B2 (es)
KR (1) KR100504122B1 (es)
CN (1) CN1094931C (es)
AT (1) ATE226199T1 (es)
AU (1) AU729423B2 (es)
BR (1) BR9712959B1 (es)
CA (1) CA2272063C (es)
DE (1) DE69716461T2 (es)
DK (1) DK0941218T3 (es)
ES (1) ES2186013T3 (es)
HU (1) HUP0000667A3 (es)
IL (1) IL129768A (es)
IT (1) IT1295694B1 (es)
PT (1) PT941218E (es)
RU (1) RU2190594C2 (es)
WO (1) WO1998021193A1 (es)

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GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IE20000052A1 (en) * 1999-04-29 2000-11-29 Russinsky Ltd Nitric acid salts of B-blockers
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
WO2001017528A1 (en) 1999-09-08 2001-03-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
JP2003514020A (ja) 1999-10-29 2003-04-15 ニトロメド インコーポレーテッド 酸化窒素不足により特徴付けられる血管疾患の治療法
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
JP2003523958A (ja) * 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
AU2001238389B2 (en) 2000-02-16 2006-09-21 Illumina, Inc. Parallel genotyping of multiple patient samples
WO2001098286A1 (en) 2000-06-22 2001-12-27 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
CA2421885A1 (en) * 2000-10-27 2002-05-02 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
DE60233140D1 (de) 2001-05-02 2009-09-10 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2003066067A2 (en) 2002-02-04 2003-08-14 Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
AU2003248642A1 (en) * 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004037843A2 (en) * 2002-10-25 2004-05-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
WO2004047837A2 (en) * 2002-11-22 2004-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-blockers having antioxidant and nitric oxide-donor activity
EP1578413A2 (en) * 2002-11-29 2005-09-28 Yissum Research Development Company of The Hebrew University of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
WO2004110432A1 (en) * 2003-06-19 2004-12-23 Nicox S.A. Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases
WO2005018561A2 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
JP2007513113A (ja) * 2003-12-02 2007-05-24 ニコックス エス エイ 抗高血圧薬剤のニトロオキシ誘導体
EP1691804B1 (en) * 2003-12-02 2007-04-04 NicOx S.A. Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive drugs
JP3984283B2 (ja) * 2004-01-05 2007-10-03 ニコックス，ソシエテ アノニム プロスタグランヂンニトロオキシ誘導体
US20060014828A1 (en) * 2004-07-16 2006-01-19 Nitromed, Inc. Compositions and methods related to heart failure
ATE462703T1 (de) * 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
WO2006052899A2 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders
WO2006078995A1 (en) * 2005-01-21 2006-07-27 Nitromed, Inc. Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
JP2009514809A (ja) * 2005-10-18 2009-04-09 ニコックス エス エイ レニン阻害剤のニトロ誘導体
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
JP2009526767A (ja) 2006-02-02 2009-07-23 アクテリオン ファーマシューティカルズ リミテッド 新規二級アミン
WO2007097951A2 (en) * 2006-02-17 2007-08-30 Nitromed, Inc. Methods using hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
EP1994026A2 (en) * 2006-03-08 2008-11-26 Actelion Pharmaceuticals Ltd. New amines
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
EP2024337A4 (en) * 2006-05-16 2011-09-14 Nitromed Inc SOLID DOSAGE FORMULATIONS OF HYDRALAZIN COMPOUNDS
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
FR2921365B1 (fr) * 2007-09-21 2012-10-12 Servier Lab Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2548134T3 (es) * 2008-05-05 2015-10-14 Actelion Pharmaceuticals Ltd. Derivados de piperidina 3,4-sustituida como inhibidores de renina
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
ES2656237T3 (es) 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
KR20190104993A (ko) 2016-11-08 2019-09-11 보오슈 앤드 롬 인코포레이팃드 정상 안압 녹내장을 치료하기 위한 산화질소 방출 프로스타글란딘 유도체
AU2020300002A1 (en) 2019-07-01 2022-02-24 Tonix Pharma Limited Anti-CD154 antibodies and uses thereof
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IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
WO1995009831A1 (en) 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CA2190087C (en) * 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
AU2230897A (en) * 1996-03-01 1997-09-16 Sankyo Company Limited Thiazolidine derivatives

Also Published As

Publication number Publication date
ATE226199T1 (de) 2002-11-15
WO1998021193A1 (en) 1998-05-22
EP0941218A1 (en) 1999-09-15
KR20000053251A (ko) 2000-08-25
EP0941218B1 (en) 2002-10-16
RU2190594C2 (ru) 2002-10-10
PT941218E (pt) 2003-03-31
BR9712959A (pt) 2000-02-01
IL129768A (en) 2004-02-19
JP2001507676A (ja) 2001-06-12
DE69716461T2 (de) 2003-06-26
HUP0000667A3 (en) 2000-08-28
DE69716461D1 (de) 2002-11-21
CN1094931C (zh) 2002-11-27
CA2272063A1 (en) 1998-05-22
BR9712959B1 (pt) 2010-06-01
DK0941218T3 (da) 2003-02-17
KR100504122B1 (ko) 2005-07-27
JP4264137B2 (ja) 2009-05-13
AU729423B2 (en) 2001-02-01
AU5551998A (en) 1998-06-03
US6242432B1 (en) 2001-06-05
IL129768A0 (en) 2000-02-29
ITMI962368A1 (it) 1998-05-14
ITMI962368A0 (it) 1996-11-14
HUP0000667A2 (en) 2000-07-28
IT1295694B1 (it) 1999-05-27
CN1242768A (zh) 2000-01-26
CA2272063C (en) 2008-05-27

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