CN109311887B - 吡唑并[1,5-a]嘧啶基甲酰胺化合物以及它们在治疗医学病症中的用途 - Google Patents

吡唑并[1,5-a]嘧啶基甲酰胺化合物以及它们在治疗医学病症中的用途 Download PDF

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CN109311887B
CN109311887B CN201780034861.3A CN201780034861A CN109311887B CN 109311887 B CN109311887 B CN 109311887B CN 201780034861 A CN201780034861 A CN 201780034861A CN 109311887 B CN109311887 B CN 109311887B
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cycloalkyl
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CN109311887A (zh
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R·T·斯考尔吉
E·M·J·布尔克
P·T·兰斯伯里
A·C·古德
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Bial Biotechnology Investment Co
Bial R&D Investments SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201780034861.3A 2016-04-06 2017-04-06 吡唑并[1,5-a]嘧啶基甲酰胺化合物以及它们在治疗医学病症中的用途 Expired - Fee Related CN109311887B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662318929P 2016-04-06 2016-04-06
US62/318,929 2016-04-06
PCT/US2017/026280 WO2017176960A1 (en) 2016-04-06 2017-04-06 Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders

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CN109311887A CN109311887A (zh) 2019-02-05
CN109311887B true CN109311887B (zh) 2022-09-13

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US (4) US11192892B2 (https=)
EP (1) EP3440080A4 (https=)
JP (1) JP7038063B2 (https=)
KR (2) KR20180133461A (https=)
CN (1) CN109311887B (https=)
AU (1) AU2017246455B2 (https=)
BR (1) BR112018070586A8 (https=)
CA (1) CA3020287A1 (https=)
IL (1) IL262177B (https=)
MX (1) MX2018012211A (https=)
SG (1) SG11201808830YA (https=)
WO (1) WO2017176960A1 (https=)

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US11192892B2 (en) 2016-04-06 2021-12-07 Bial—R&D Investments, S.A. Substituted pyrazolo[1,5-a]pyrimidines for the treatment of medical disorders
EP3440081A4 (en) 2016-04-06 2019-09-18 Lysosomal Therapeutics Inc. PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER
SG11201809693SA (en) 2016-05-05 2018-11-29 Lysosomal Therapeutics Inc SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
EP3452455A4 (en) 2016-05-05 2019-11-13 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES
CN110698484B (zh) * 2019-06-05 2021-11-05 陕西理工大学 含吡唑并[1,5-a]嘧啶的衍生物、药用组合物及应用
CN115108972A (zh) * 2022-08-29 2022-09-27 北京迪泰医药科技有限公司 一种2-甲基-3-氟-5-溴吡啶的合成方法
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WO2025146216A1 (zh) * 2024-01-05 2025-07-10 成都赜灵生物医药科技有限公司 六并五氮杂环酰胺类化合物及其用途
CN118184599A (zh) * 2024-02-29 2024-06-14 重庆药友制药有限责任公司 一种阿莫奈韦中间体的制备方法

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