CN109153860B - 具有间隔连接体基团的超高亮二聚体或聚合物染料 - Google Patents

具有间隔连接体基团的超高亮二聚体或聚合物染料 Download PDF

Info

Publication number
CN109153860B
CN109153860B CN201780029475.5A CN201780029475A CN109153860B CN 109153860 B CN109153860 B CN 109153860B CN 201780029475 A CN201780029475 A CN 201780029475A CN 109153860 B CN109153860 B CN 109153860B
Authority
CN
China
Prior art keywords
compound
independently
linker
moiety
specific value
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780029475.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN109153860A (zh
Inventor
T·马特雷
S·辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Corp
Sony Group Corp
Original Assignee
Sony Corp
Optical Archive Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Corp, Optical Archive Inc filed Critical Sony Corp
Publication of CN109153860A publication Critical patent/CN109153860A/zh
Application granted granted Critical
Publication of CN109153860B publication Critical patent/CN109153860B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/098—Esters of polyphosphoric acids or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/26—Triarylmethane dyes in which at least one of the aromatic nuclei is heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B3/00—Dyes with an anthracene nucleus condensed with one or more carbocyclic rings
    • C09B3/14—Perylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/101—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/101—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye
    • C09B69/102—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an anthracene dye containing a perylene dye
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/103—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a diaryl- or triarylmethane dye
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Paints Or Removers (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201780029475.5A 2016-04-06 2017-04-06 具有间隔连接体基团的超高亮二聚体或聚合物染料 Active CN109153860B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662318935P 2016-04-06 2016-04-06
US62/318,935 2016-04-06
PCT/US2017/026451 WO2017177065A2 (en) 2016-04-06 2017-04-06 Ultra bright dimeric or polymeric dyes with spacing linker groups

Publications (2)

Publication Number Publication Date
CN109153860A CN109153860A (zh) 2019-01-04
CN109153860B true CN109153860B (zh) 2021-04-23

Family

ID=58610016

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780029475.5A Active CN109153860B (zh) 2016-04-06 2017-04-06 具有间隔连接体基团的超高亮二聚体或聚合物染料

Country Status (9)

Country Link
US (7) US9851359B2 (enExample)
EP (2) EP3440136B1 (enExample)
JP (3) JP7069033B2 (enExample)
KR (3) KR20180133890A (enExample)
CN (1) CN109153860B (enExample)
AU (3) AU2017248165B2 (enExample)
CA (1) CA3019951A1 (enExample)
RU (2) RU2021124058A (enExample)
WO (1) WO2017177065A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
KR101829159B1 (ko) 2014-01-16 2018-02-13 소니 주식회사 수용성 형광 또는 유색 염료
EP3262022A4 (en) 2015-02-26 2018-08-15 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
JP6849599B2 (ja) 2015-05-11 2021-03-24 ソニー株式会社 超明色ダイマーまたはポリマー染料
KR102773661B1 (ko) 2016-04-01 2025-02-27 소니그룹주식회사 초휘도 이량체성 또는 중합체성 염료
WO2017173348A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
RU2021124058A (ru) * 2016-04-06 2021-09-10 Сони Корпорейшн Ультраяркие димерные или полимерные красители со спейсерными линкерными группами
JP7068192B2 (ja) 2016-05-10 2022-05-16 ソニーグループ株式会社 ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用
EP3455238A1 (en) 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
CA3021419A1 (en) 2016-05-11 2017-11-16 Sony Corporation Ultra bright dimeric or polymeric dyes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP4075133A3 (en) 2017-06-16 2022-11-23 Duke University Resonator networks for improved label detection, computation, analyte sensing, and tunable random number generation
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
KR20200083605A (ko) 2017-11-16 2020-07-08 소니 주식회사 프로그램가능한 중합체성 약물
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
WO2019140227A1 (en) 2018-01-12 2019-07-18 Sony Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
KR102742386B1 (ko) * 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
CN118480073A (zh) 2018-03-21 2024-08-13 索尼公司 具有连接体基团的聚合串联染料
CN112384573A (zh) 2018-03-30 2021-02-19 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
CN112313242A (zh) 2018-06-27 2021-02-02 索尼公司 具有含脱氧核糖的连接体基团的聚合物染料
US20210285953A1 (en) 2018-07-13 2021-09-16 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
JP7603918B2 (ja) * 2019-04-11 2024-12-23 ソニーグループ株式会社 プログラム可能なポリマー薬
JP7551060B2 (ja) * 2019-04-11 2024-09-17 ソニーグループ株式会社 プログラム可能なポリマー薬
EP3861074A2 (en) * 2019-09-26 2021-08-11 Sony Group Corporation Polymeric tandem dyes with linker groups
KR20220075399A (ko) * 2019-09-30 2022-06-08 소니그룹주식회사 뉴클레오티드 프로브
JP2023550791A (ja) 2020-11-25 2023-12-05 ソニーグループ株式会社 ポリマー色素
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN116917738A (zh) 2021-04-07 2023-10-20 贝克顿·迪金森公司 水溶性荧光聚合物染料
WO2023242661A2 (en) 2022-06-15 2023-12-21 Sony Group Corporation Polymeric tandem dyes with spacing linker groups
CN119546706A (zh) 2022-06-15 2025-02-28 索尼集团公司 具有间隔连接基基团的聚合物串联染料
GB202301468D0 (en) * 2023-02-01 2023-03-15 Univ Oxford Innovation Ltd Sulphide sensing assembly

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366785A4 (en) * 2008-11-14 2012-06-27 Japan Science & Tech Agency OLIGONUCLEOTIDE DERIVATIVES, MARKING AGENTS AND THE MARKETING AGENT
CN105377994A (zh) * 2013-08-22 2016-03-02 索尼公司 水溶性荧光染料或有色染料及其使用方法
CN107580618A (zh) * 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料
CN107709470A (zh) * 2015-05-11 2018-02-16 索尼公司 超亮二聚或多聚染料

Family Cites Families (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450305A (en) 1982-10-25 1984-05-22 American Cyanamid Company Poly(ethyleneoxy)-substituted-9,10-bis(phenylethynyl)anthracenes
US4476229A (en) 1982-11-08 1984-10-09 Abbott Laboratories Substituted carboxyfluoresceins
SU1121931A1 (ru) 1983-01-10 1988-04-15 Институт Биологической Химии Ан Бсср Конъюгаты тиреоидных гормонов с альбумином дл выработки антител к тиреоидным гормонам у животных
EP0355864A3 (en) 1984-03-15 1991-09-18 Wako Pure Chemical Industries, Ltd. Method of quantitatively measuring an oxidative substance by using triphenyl methane type leuco compounds as coloring matter
JPH0665677B2 (ja) 1985-03-09 1994-08-24 三菱化成株式会社 リン脂質類似構造を有するジオ−ルおよびその製造方法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5053054A (en) 1988-09-12 1991-10-01 Ortho Pharmaceutical Corporation Methods and reagents for staining intracellular components
US5318894A (en) 1990-01-30 1994-06-07 Miles Inc. Composition, device and method of assaying for peroxidatively active substances
US6365730B1 (en) 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JPH04282391A (ja) 1991-03-08 1992-10-07 Fujisawa Pharmaceut Co Ltd エタノールアミン誘導体およびその製造法
US5698391A (en) 1991-08-23 1997-12-16 Isis Pharmaceuticals, Inc. Methods for synthetic unrandomization of oligomer fragments
ATE152831T1 (de) 1991-09-16 1997-05-15 Molecular Probes Inc Dimere unsymmetrische cyaninfarbstoffe
DE69231853T2 (de) 1991-11-07 2001-09-13 Nanotronics, Inc. Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems
CZ333194A3 (en) 1992-07-03 1995-11-15 Detlef Reh Process and apparatus for waste water treatment
PT693065E (pt) 1993-04-13 2002-05-31 Naxcor Derivados de cumarina nao-nucleosidicos como agentes reticulantes de polionucleotidos
JPH09500411A (ja) 1993-07-13 1997-01-14 アボツト・ラボラトリーズ 蛍光性ポリマー標識された接合体および中間体
ATE227342T1 (de) 1993-09-02 2002-11-15 Ribozyme Pharm Inc Enzymatische nukleiksaüre die nicht-nukleotide enthaltet
US5886177A (en) 1994-01-11 1999-03-23 Isis Pharmaceuticals, Inc. Phosphate linked oligomers
US6171859B1 (en) 1994-03-30 2001-01-09 Mitokor Method of targeting conjugate molecules to mitochondria
JP4098839B2 (ja) 1995-01-30 2008-06-11 株式会社同仁化学研究所 インドシアニン化合物
US5994143A (en) 1996-02-01 1999-11-30 Abbott Laboratories Polymeric fluorophores enhanced by moieties providing a hydrophobic and conformationally restrictive microenvironment
US6218108B1 (en) 1997-05-16 2001-04-17 Research Corporation Technologies, Inc. Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor
DE19633268A1 (de) 1996-08-19 1998-02-26 Hoechst Ag Polymere Gallensäure-Resorptionsinhibitoren mit gleichzeitiger Gallensäure-Adsorberwirkung
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
JP2001511128A (ja) 1997-01-28 2001-08-07 ファルマシア・アンド・アップジョン・カンパニー 水不溶性ポルフィリンの脂質錯体の凍結乾燥物
US6893868B2 (en) 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US5986030A (en) 1997-04-15 1999-11-16 Nalco Chemical Company Fluorescent water soluble polymers
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
JP3078793B2 (ja) 1998-04-30 2000-08-21 株式会社分子バイオホトニクス研究所 ロタキサン構造を有する色素、ラベル化剤、およびラベル化方法
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6514700B1 (en) 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US20020142329A1 (en) 1999-04-30 2002-10-03 Aclara Biosciences, Inc. Compositions and methods employing cleavable electrophoretic tag reagents
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
WO2001007430A1 (en) 1999-07-22 2001-02-01 Nalco Chemical Compant Fluorescent water-soluble polymers
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US6479650B1 (en) 1999-12-14 2002-11-12 Research Corporation Technologies, Inc. Fluorescent nucleoside analogs and combinatorial fluorophore arrays comprising same
EP1266222A2 (en) 2000-03-14 2002-12-18 Genigma Corporation Visually detectable dye labelled biomolecules for analysis
WO2001073123A2 (en) * 2000-03-28 2001-10-04 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20040067498A1 (en) 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
WO2001085997A1 (en) 2000-05-08 2001-11-15 Qtl Biosystems Llc Improvements to the fluorescent polymer-qtl approach to biosensing
WO2001091725A2 (en) 2000-05-31 2001-12-06 Univ Johns Hopkins Biologically useful polyphosphates
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
WO2002022883A1 (en) 2000-09-11 2002-03-21 The Trustees Of Columbia University In The City Of New York Combinatorial fluorescence energy transfer tags and uses thereof
CA2424454C (en) 2000-09-19 2010-07-20 Li-Cor, Inc. Cyanine dyes
US6448407B1 (en) 2000-11-01 2002-09-10 Pe Corporation (Ny) Atropisomers of asymmetric xanthene fluorescent dyes and methods of DNA sequencing and fragment analysis
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
GB2372256A (en) 2001-02-14 2002-08-21 Kalibrant Ltd Detectable entity comprising a plurality of detectable units releasably connected together by stimulus-cleavable linkers for use in fluorescence detection
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
JP3813890B2 (ja) 2002-03-22 2006-08-23 富士写真フイルム株式会社 ３層レジストプロセス用中間層材料組成物及びそれを用いたパターン形成方法
US20040086914A1 (en) 2002-07-12 2004-05-06 Affymetrix, Inc. Nucleic acid labeling methods
WO2004019002A2 (en) 2002-08-23 2004-03-04 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent glycosides and methods for their use
WO2004092324A2 (en) 2002-08-26 2004-10-28 The Regents Of The University Of California Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US20040138467A1 (en) 2002-11-26 2004-07-15 French Roger Harquail Aromatic and aromatic/heteroaromatic molecular structures with controllable electron conducting properties
WO2004062475A2 (en) 2003-01-10 2004-07-29 Albert Einstein College Of Medicine Of Yeshiva University Fluorescent assays for protein kinases
US7238792B2 (en) 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US7172907B2 (en) 2003-03-21 2007-02-06 Ge Healthcare Bio-Sciences Corp. Cyanine dye labelling reagents with meso-substitution
EP1653989B1 (fr) 2003-08-14 2009-07-15 Diatos Composition anti-bacterienne plus particulierement contre les bacteries gram negatif comprenent un peptide et un agent anti-bacterien avantageusement hydrophobe
WO2005051967A2 (en) 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
AU2003296419A1 (en) 2003-12-09 2005-07-21 Molecular Probes, Inc. Pyrenyloxysulfonic acid fluorescent agents
WO2006078278A2 (en) 2004-04-27 2006-07-27 Alnylam Pharmaceuticals, Inc. Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
WO2006002167A2 (en) 2004-06-17 2006-01-05 University Of Florida Research Foudation, Inc. Multi-acceptor molecular probes and applications thereof
US20060035302A1 (en) 2004-06-21 2006-02-16 Applera Corporation Kinase substrates with multiple phosphorylation sites
WO2006020947A2 (en) 2004-08-13 2006-02-23 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates
US8586718B2 (en) 2004-09-14 2013-11-19 Applied Biosystems, Llc Multi-chromophoric quencher constructs for use in high sensitivity energy transfer probes
US8153706B2 (en) 2004-10-25 2012-04-10 Hewlett-Packard Development Company, L.P. Polymeric colorants having pigment and dye components and corresponding ink compositions
ATE364643T1 (de) 2004-11-09 2007-07-15 Ipagsa Ind Sl Thermisch reaktive, nah-infrarot absorbierende polymere und ihre verwendung in wärmeempfindlichen lithographischen druckplatten
EP2502946B1 (en) 2005-01-10 2017-10-04 The Regents of The University of California Cationic conjugated polymers suitable for strand-specific polynucleiotide detection in homogeneous and solid state assays
CN101137735A (zh) 2005-03-09 2008-03-05 西菲伊德公司 极性染料
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
US8158801B2 (en) 2005-09-26 2012-04-17 Life Technologies Corporation Violet laser excitable dyes and their method of use
EP1949108B1 (en) * 2005-11-18 2013-09-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Modified cardiolipin and uses therefor
JP5410760B2 (ja) 2005-12-12 2014-02-05 チバ ホールディング インコーポレーテッド 半導体素子、化合物、半導体素子の半導体層及び薄膜トランジスタ素子を作製する方法
US20070148094A1 (en) 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
WO2007094135A1 (ja) 2006-02-15 2007-08-23 Gifu University オリゴヌクレオチド誘導体及びその利用
ES2369608T3 (es) * 2006-04-13 2011-12-02 Midatech Ltd. Nanopartículas que contienen tres ligandos diferentes para proporcionar respuestas inmunitarias frente a agentes infecciosos.
WO2008021208A2 (en) 2006-08-12 2008-02-21 Stx Aprilis, Inc. Sensitizer dyes for photoacid generating systems using short visible wavelengths
US8217389B2 (en) 2006-10-12 2012-07-10 Idemitsu Kosan, Co., Ltd. Organic thin film transistor device and organic thin film light-emitting transistor
EP2064290B1 (en) 2006-10-27 2013-10-09 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
US8053588B2 (en) 2007-03-07 2011-11-08 Kabushiki Kaisha Toyota Chuo Kenkyusho Organosilane compound and organosilica obtained therefrom
ES2516827T3 (es) 2007-04-23 2014-10-31 Deliversir Ltd Un sistema para entregar agentes terapéuticos a células vivas y núcleos de células
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
US9156865B2 (en) * 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
JP5518697B2 (ja) 2007-05-11 2014-06-11 ビーエーエスエフ ソシエタス・ヨーロピア 高分子色素
EP2014698A1 (en) 2007-07-12 2009-01-14 Crystax Pharmaceuticals S.L. Polymers and their use as fluorescent labels
TWI409280B (zh) 2007-07-31 2013-09-21 American Dye Source Inc 聚合物染料、塗覆層組合物及熱微影印刷板
GB2456298A (en) 2008-01-07 2009-07-15 Anthony Ian Newman Electroluminescent materials comprising oxidation resistant fluorenes
CA2718003C (en) 2008-03-10 2016-05-03 The University Of Tokyo Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
CN102083850B (zh) 2008-04-21 2015-08-12 加利福尼亚大学董事会 选择性高亲和力多齿配体及其制备方法
US20100021901A1 (en) 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
KR101041446B1 (ko) 2008-07-21 2011-06-14 부산대학교 산학협력단 공액고분자 2단계 ｆｒｅｔ 시스템 및 바이오센서
JPWO2010026957A1 (ja) 2008-09-03 2012-02-02 国立大学法人富山大学 水溶性ロタキサン型蛍光色素および蛍光性有機分子
JP5798487B2 (ja) 2008-11-20 2015-10-21 ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー Ｆｒｅｔに基づく病原体の迅速診断
EP2356167A4 (en) 2008-12-12 2012-07-11 Univ Massachusetts POLYESTER WITH POTTED TWITTERS
AU2010273431B2 (en) 2009-07-16 2016-08-25 Beckman Coulter, Inc. Novel fluorescent dyes and uses thereof
US10191060B2 (en) 2009-11-09 2019-01-29 University Of Washington Functionalized chromophoric polymer dots and bioconjugates thereof
US9400273B1 (en) 2009-12-09 2016-07-26 Life Technologies Corporation 7-hydroxycoumarin-based cell-tracking reagents
JP2011135823A (ja) 2009-12-28 2011-07-14 Nagoya Univ オリゴヌクレオチドプローブ及びその利用
US9221759B2 (en) 2010-01-13 2015-12-29 Rutgers, The State University Of New Jersey Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency
EP2545373B1 (en) 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
JP2013528665A (ja) 2010-03-26 2013-07-11 メルサナ セラピューティックス， インコーポレイテッド ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法
EP2577309B1 (en) 2010-05-25 2016-11-23 Carnegie Mellon University Targeted probes of cellular physiology
CN102971283A (zh) 2010-07-08 2013-03-13 旭硝子株式会社 含氟芳香族化合物、有机半导体材料和有机薄膜器件
WO2012039741A1 (en) 2010-09-22 2012-03-29 The Board Of Regents Of The University Of Texas System Novel block copolymer and micelle compositions and methods of use thereof
US8846941B2 (en) 2010-12-13 2014-09-30 Quiapeg Ab Functionalized polymers
WO2012086857A1 (ko) 2010-12-21 2012-06-28 (주)파낙스이엠 광역학 진단 또는 치료를 위한 결합체 및 이의 제조방법
CN102174078A (zh) 2011-01-10 2011-09-07 中国药科大学 肿瘤细胞选择性穿膜肽的应用
CA2857493C (en) 2011-07-15 2019-06-11 Glumetrics, Inc. Combinations of fluorphores and pyridinium boronic acid quenchers for use in analyte sensors
WO2013033438A2 (en) 2011-08-31 2013-03-07 Mallinckrodt Llc Nanoparticle peg modification with h-phosphonates
US20130059343A1 (en) * 2011-09-06 2013-03-07 Li-Cor, Inc. Nucleotide derivatives
WO2013112366A1 (en) * 2012-01-24 2013-08-01 Siemens Aktiengesellschaft Method and system for motion estimation model for cardiac and respiratory motion compensation
US9085761B1 (en) * 2012-06-14 2015-07-21 Affymetrix, Inc. Methods and compositions for amplification of nucleic acids
BR112015004747A2 (pt) 2012-09-12 2017-11-21 Quark Pharmaceuticals Inc moléculas oligonucleotídicas de fita dupla para p53 e métodos de uso das mesmas
WO2014055253A1 (en) 2012-10-04 2014-04-10 The General Hospital Corporation Methods of synthesizing and using peg-like fluorochromes
CN104918639B (zh) 2012-10-22 2018-01-26 萨拜格Rfa公司 用于将治疗剂递送到活细胞和细胞核中的系统
WO2014102803A1 (en) 2012-12-31 2014-07-03 Yeda Research And Development Co. Ltd. Molecular sensor and methods of use thereof
US9545447B2 (en) 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
US9169256B2 (en) 2013-03-13 2015-10-27 Elitechgroup B.V. Artificial nucleic acids
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
JP6606487B2 (ja) 2013-03-15 2019-11-13 ビセン メディカル， インコーポレイテッド ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素
WO2014147642A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research Substituted fluoranthene-7-carbonitriles as fluorescent dyes for cell imaging applications
CN103319378B (zh) 2013-06-27 2015-06-10 中国科学院宁波材料技术与工程研究所 两性离子有机小分子太阳能电池阴极界面材料及其制法和用途
KR101572901B1 (ko) 2013-07-12 2015-12-15 부산대학교 산학협력단 2-단계 fret를 이용한 공액고분자 전해질 및 압타머 프로브 기반 표적 물질의 검출 방법 및 형광 센서
US9173924B2 (en) 2013-08-22 2015-11-03 Zp Opco, Inc. Stable glucagon peptide formulations
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
CA2927366A1 (en) 2013-10-24 2015-04-30 Uniqure Ip B.V. Aav-5 pseudotyped vector for gene therapy for neurological diseases
JP5802865B1 (ja) 2013-11-11 2015-11-04 オリンパス株式会社 処置システム
US9150782B2 (en) 2013-12-06 2015-10-06 Monosol, Llc Fluorescent tracer for water-soluble films, related methods, and related articles
JP6461973B2 (ja) 2013-12-20 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用
KR101829159B1 (ko) 2014-01-16 2018-02-13 소니 주식회사 수용성 형광 또는 유색 염료
JP6374172B2 (ja) 2014-01-31 2018-08-15 富士フイルム株式会社 着色組成物、およびこれを用いた硬化膜、カラーフィルタ、パターン形成方法、カラーフィルタの製造方法、固体撮像素子、画像表示装置ならびに染料多量体
JP6650880B2 (ja) 2014-03-11 2020-02-19 ストライカー・コーポレイション 容器内環境を監視するためのバッテリー駆動センサモジュールを有する滅菌容器
CN104072727A (zh) 2014-06-23 2014-10-01 华南理工大学 一种含磷脂酰胆碱基的2,7-芴的共轭聚合物及其制备方法与应用
MX2017004580A (es) 2014-10-10 2017-06-27 Pfizer Combinaciones de auristatina sinergica.
US10709791B2 (en) 2014-11-12 2020-07-14 University Of Washington Stabilized polymeric carriers for therapeutic agent delivery
EP3218414A1 (en) 2014-11-14 2017-09-20 Angiochem Inc. Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin
DK178808B1 (en) 2014-12-12 2017-02-13 Envision Energy Denmark Aps Floating wind turbine structure with reduced tower height and method for optimising the weight thereof
KR102676814B1 (ko) 2015-02-26 2024-06-21 소니그룹주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
EP3262022A4 (en) 2015-02-26 2018-08-15 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
JP7390778B2 (ja) 2015-03-12 2023-12-06 ベクトン・ディキンソン・アンド・カンパニー ポリマーｂｏｄｉｐｙ色素およびそれを使用する方法
EP3283499B1 (en) 2015-04-15 2022-07-06 Biosearch Technologies, Inc. Dual quencher probes
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
EP3303420B1 (en) 2015-06-02 2022-04-06 University of Washington Free-standing non-fouling polymers, their compositions, and related monomers
CN108289964B (zh) 2015-08-10 2022-08-12 杭州多禧生物科技有限公司 新型连接体及其用于药物和生物分子的特异性偶联
EP3359194A4 (en) 2015-10-06 2019-04-24 Merck Sharp & Dohme Corp. ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
CN112451682A (zh) 2015-11-25 2021-03-09 乐高化学生物科学股份有限公司 包含自降解基团的缀合物及其相关方法
JP6841430B2 (ja) 2015-12-04 2021-03-10 全薬工業株式会社 血中滞留性を改善した抗ｉｌ−１７アプタマー
US9913992B2 (en) 2015-12-22 2018-03-13 Colgate-Palmolive Company Oral treatment device
JP2017124994A (ja) 2016-01-15 2017-07-20 靖彦 中村 癌治療及び癌再発防止のための装置並びにポルフィリン類含有製剤
WO2017173348A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
RU2021124058A (ru) 2016-04-06 2021-09-10 Сони Корпорейшн Ультраяркие димерные или полимерные красители со спейсерными линкерными группами
EP3455238A1 (en) 2016-05-10 2019-03-20 Sony Corporation Ultra bright polymeric dyes with peptide backbones
JP7068192B2 (ja) 2016-05-10 2022-05-16 ソニーグループ株式会社 ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用
CA3021419A1 (en) 2016-05-11 2017-11-16 Sony Corporation Ultra bright dimeric or polymeric dyes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP3507603B1 (en) 2016-09-01 2024-03-06 Life Technologies Corporation Compositions and methods for enhanced fluorescence
GB2554666B (en) 2016-09-30 2019-12-18 Sumitomo Chemical Co Composite Particle
CN106589005B (zh) 2016-11-01 2019-08-06 北京擎科生物科技有限公司 一种荧光信号放大探针中间体、荧光探针及其制备方法
US10834091B2 (en) 2017-02-27 2020-11-10 Ivanti, Inc. Systems and methods for role-based computer security configurations
US12398104B2 (en) 2017-04-27 2025-08-26 The Procter & Gamble Company Odorless thiols for permanent waving, straightening and depilatory applications
CN110869354A (zh) 2017-07-07 2020-03-06 美国政府(由卫生和人类服务部的部长所代表) 脂肪酸衍生物及其用途
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
KR20200067132A (ko) 2017-10-05 2020-06-11 소니 주식회사 프로그램가능한 중합체성 약물
KR20200083605A (ko) 2017-11-16 2020-07-08 소니 주식회사 프로그램가능한 중합체성 약물
KR102773157B1 (ko) 2017-12-13 2025-02-27 소니그룹주식회사 생물학적 활성 화합물을 함유하는 이온성 중합체
EP3727463A1 (en) 2017-12-21 2020-10-28 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
WO2019140227A1 (en) 2018-01-12 2019-07-18 Sony Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
CN111565756A (zh) 2018-01-12 2020-08-21 索尼公司 包含生物活性化合物的具有刚性间隔基团的聚合物
US20200360526A1 (en) 2018-01-12 2020-11-19 Sony Corporation Phosphoalkyl polymers comprising biologically active compounds
KR102742386B1 (ko) 2018-03-19 2024-12-16 소니그룹주식회사 형광 신호 향상을 위한 2가 금속의 사용
CN118480073A (zh) * 2018-03-21 2024-08-13 索尼公司 具有连接体基团的聚合串联染料
GB201807815D0 (en) 2018-05-14 2018-06-27 Hypha Discovery Ltd Hydroxylation techniques
US10755781B2 (en) 2018-06-06 2020-08-25 Micron Technology, Inc. Techniques for programming multi-level self-selecting memory cell
CN112313242A (zh) 2018-06-27 2021-02-02 索尼公司 具有含脱氧核糖的连接体基团的聚合物染料
US20210285953A1 (en) 2018-07-13 2021-09-16 Sony Corporation Polymeric dyes having a backbone comprising organophosphate units
JP7618137B2 (ja) 2019-04-11 2025-01-21 ソニーグループ株式会社 プログラム可能なポリマー薬
JP7551060B2 (ja) 2019-04-11 2024-09-17 ソニーグループ株式会社 プログラム可能なポリマー薬
JP7603918B2 (ja) 2019-04-11 2024-12-23 ソニーグループ株式会社 プログラム可能なポリマー薬
JP7650819B2 (ja) 2019-04-24 2025-03-25 ブイオーアール バイオファーマ インコーポレーテッド 抗－ｃｄ４５抗体薬物コンジュゲート及びその使用
EP3861074A2 (en) 2019-09-26 2021-08-11 Sony Group Corporation Polymeric tandem dyes with linker groups
KR20220075399A (ko) 2019-09-30 2022-06-08 소니그룹주식회사 뉴클레오티드 프로브
JP2023550791A (ja) 2020-11-25 2023-12-05 ソニーグループ株式会社 ポリマー色素
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
JP2024527253A (ja) 2021-06-16 2024-07-24 ソニーグループ株式会社 分析対象分子の目視検出のためのフルオロフォア及び発色団含有コンジュゲートを調製する方法
JP2024526884A (ja) 2021-07-22 2024-07-19 ソニーグループ株式会社 ポリマー薬物の自動合成
WO2023052970A1 (en) 2021-09-30 2023-04-06 Sony Group Corporation Pyrrolobenzodiazepine conjugates for cancer treatment
EP4408473A1 (en) 2021-09-30 2024-08-07 Sony Group Corporation Automated synthesis of polymeric dual drugs

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2366785A4 (en) * 2008-11-14 2012-06-27 Japan Science & Tech Agency OLIGONUCLEOTIDE DERIVATIVES, MARKING AGENTS AND THE MARKETING AGENT
CN105377994A (zh) * 2013-08-22 2016-03-02 索尼公司 水溶性荧光染料或有色染料及其使用方法
CN107709470A (zh) * 2015-05-11 2018-02-16 索尼公司 超亮二聚或多聚染料
CN107580618A (zh) * 2016-04-01 2018-01-12 索尼公司 超亮二聚或多聚染料

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Monitoring the Hydrophobic Interactions of Internally Pyrene-Labeled Poly(ethylene oxide)s in Water by Fluorescence Spectroscopy;Sam Lee，等;《Macromolecules》;19981231;第31卷(第26期);第9193-9200页表1和示意图1 *

Also Published As

Publication number Publication date
US20230129481A1 (en) 2023-04-27
BR112018070533A2 (pt) 2019-02-12
CA3019951A1 (en) 2017-10-12
JP7432123B2 (ja) 2024-02-16
RU2018138590A3 (enExample) 2021-01-18
EP3440136A2 (en) 2019-02-13
US20240255514A1 (en) 2024-08-01
US20200284798A1 (en) 2020-09-10
US20170292957A1 (en) 2017-10-12
KR20230066645A (ko) 2023-05-16
US20180164322A1 (en) 2018-06-14
JP2024023205A (ja) 2024-02-21
WO2017177065A3 (en) 2017-11-09
KR20250012201A (ko) 2025-01-23
AU2017248165A1 (en) 2018-10-11
JP2022115953A (ja) 2022-08-09
US9851359B2 (en) 2017-12-26
AU2021266230B2 (en) 2024-01-18
JP7069033B2 (ja) 2022-05-17
RU2018138590A (ru) 2020-05-19
US10989715B2 (en) 2021-04-27
JP2019516821A (ja) 2019-06-20
US20210096135A1 (en) 2021-04-01
WO2017177065A2 (en) 2017-10-12
RU2021124058A (ru) 2021-09-10
AU2024202205B2 (en) 2025-09-11
AU2021266230A1 (en) 2021-12-02
CN109153860A (zh) 2019-01-04
AU2017248165B2 (en) 2021-08-26
US12270812B2 (en) 2025-04-08
US10866244B2 (en) 2020-12-15
US20240248094A1 (en) 2024-07-25
AU2024202205A1 (en) 2024-05-02
KR102756931B1 (ko) 2025-01-21
RU2753706C2 (ru) 2021-08-20
EP4641204A2 (en) 2025-10-29
KR20180133890A (ko) 2018-12-17
EP3440136B1 (en) 2025-07-23
US12461106B2 (en) 2025-11-04

Similar Documents

Publication Publication Date Title
CN109153860B (zh) 具有间隔连接体基团的超高亮二聚体或聚合物染料
KR102742386B1 (ko) 형광 신호 향상을 위한 2가 금속의 사용
CN112399996A (zh) 具有包含有机磷酸酯单元的主链的聚合的染料
EP4256078A1 (en) Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
CN119585368A (zh) 具有间隔连接基基团的聚合物串联染料
CN117280043A (zh) 用于二聚物或聚合物染料中亮度增强的间隔连接基设计
BR112018070533B1 (pt) Corantes diméricos ou poliméricos ultrabrilhantes com grupos agentes de ligação espaçadores

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP03 Change of name, title or address

Address after: Japan

Patentee after: Sony Group

Country or region after: Japan

Address before: Japan

Patentee before: Sony Corp.

Country or region before: Japan

CP03 Change of name, title or address
TR01 Transfer of patent right

Effective date of registration: 20240920

Address after: Japan

Patentee after: Sony Corp.

Country or region after: Japan

Address before: Tokyo, Japan

Patentee before: Sony Corp.

Country or region before: Japan

Patentee before: OPTICAL ARCHIVE Inc.

Country or region before: U.S.A.

TR01 Transfer of patent right