CN1087289C - 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 - Google Patents

制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 Download PDF

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CN1087289C
CN1087289C CN96195631A CN96195631A CN1087289C CN 1087289 C CN1087289 C CN 1087289C CN 96195631 A CN96195631 A CN 96195631A CN 96195631 A CN96195631 A CN 96195631A CN 1087289 C CN1087289 C CN 1087289C
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amorphous
methylethyl
fluorophenyl
pyrrole
dihydroxy
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CN1190956A (zh
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M·林
D·施维斯
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Warner Lambert Co LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN96195631A 1995-07-17 1996-07-16 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 Expired - Lifetime CN1087289C (zh)

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US145395P 1995-07-17 1995-07-17
US60/001,453 1995-07-17

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CN1190956A CN1190956A (zh) 1998-08-19
CN1087289C true CN1087289C (zh) 2002-07-10

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CN96195631A Expired - Lifetime CN1087289C (zh) 1995-07-17 1996-07-16 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法

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CA2427255A1 (en) * 2000-11-16 2002-06-06 Teva Pharmaceutical Industries Ltd. Hydrolysis of [r(r*,r*)]-2-(4-fluorophenyl)-.beta.,.delta. -dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
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WO2002057228A1 (en) * 2001-01-17 2002-07-25 Biocon India Limited Atorvastatin calcium
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SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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CZ2004943A3 (cs) * 2002-03-18 2005-02-16 Biocon Limited Amorfní HMG-CoA inhibitory obsahující reduktázu s požadovanou velikostí částic
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
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US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US7557238B2 (en) 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
PL1727795T3 (pl) * 2004-03-17 2012-06-29 Ranbaxy Laboratories Ltd Sposób wytwarzania soli wapniowej atorwastatyny w formie bezpostaciowej
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CN101039906A (zh) * 2004-10-18 2007-09-19 特瓦制药工业有限公司 通过将盐溶解于有机溶剂并除去该溶剂来制备无定形阿托伐他汀半钙的方法，所述有机溶剂为醇和酮和 /或酯的混合物
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BG63631B1 (bg) 2002-07-31
PL191017B1 (pl) 2006-03-31
ZA966043B (en) 1997-02-03
HRP960312B1 (en) 2001-10-31
EA199800128A1 (ru) 1998-08-27
DK0839132T5 (da) 2006-03-20
CN1190956A (zh) 1998-08-19
CA2220455C (en) 2002-09-24
IN185276B (cg-RX-API-DMAC10.html) 2000-12-16
CA2220455A1 (en) 1997-02-06
KR19990029045A (ko) 1999-04-15
NO980209D0 (no) 1998-01-16
PE1698A1 (es) 1998-02-19
DK0839132T3 (da) 2001-04-09
GR3035859T3 (en) 2001-08-31
US6274740B1 (en) 2001-08-14
EE03605B1 (et) 2002-02-15
RO120069B1 (ro) 2005-08-30
IL122161A (en) 1999-07-14
IL122161A0 (en) 1998-04-05
EP0839132A1 (en) 1998-05-06
NO309322B1 (no) 2001-01-15
JP4064459B2 (ja) 2008-03-19
HUP9903017A3 (en) 2001-01-29
JPH11510486A (ja) 1999-09-14
SK5898A3 (en) 1998-08-05
CO4700441A1 (es) 1998-12-29
BR9609714A (pt) 1999-02-23
AU700794B2 (en) 1999-01-14
CZ289421B6 (cs) 2002-01-16
BG102188A (en) 1998-08-31
UA50743C2 (uk) 2002-11-15
PT839132E (pt) 2001-06-29
AU6497896A (en) 1997-02-18
MX9708959A (es) 1998-03-31
DE69611999D1 (de) 2001-04-12
NO980209L (no) 1998-01-16
WO1997003960A1 (en) 1997-02-06
UY24286A1 (es) 1997-01-17
SK283204B6 (sk) 2003-03-04
ES2156997T3 (es) 2001-08-01
HK1018054A1 (en) 1999-12-10
GEP20002027B (en) 2000-04-10
NZ313008A (en) 2000-01-28
EA000625B1 (ru) 1999-12-29
DE69611999T2 (de) 2001-07-26
SI0839132T1 (cg-RX-API-DMAC10.html) 2001-06-30
HU220343B (hu) 2001-12-28
CZ12298A3 (cs) 1998-12-16
EE9700369A (et) 1998-06-15
HRP960312A2 (en) 1998-02-28
ATE199542T1 (de) 2001-03-15
AR002849A1 (es) 1998-04-29
PL324463A1 (en) 1998-05-25
KR100400805B1 (ko) 2003-12-24

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