CN108348772A - 用于治疗脑组织的组织摧毁术治疗系统和方法 - Google Patents
用于治疗脑组织的组织摧毁术治疗系统和方法 Download PDFInfo
- Publication number
- CN108348772A CN108348772A CN201680045860.4A CN201680045860A CN108348772A CN 108348772 A CN108348772 A CN 108348772A CN 201680045860 A CN201680045860 A CN 201680045860A CN 108348772 A CN108348772 A CN 108348772A
- Authority
- CN
- China
- Prior art keywords
- transducer
- piezoelectric
- ultrasonic pulse
- ultrasonic
- energy converter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/003—Destruction of nerve tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0039—Ultrasound therapy using microbubbles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0047—Ultrasound therapy interstitial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0056—Beam shaping elements
- A61N2007/0065—Concave transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0086—Beam steering
- A61N2007/0095—Beam steering by modifying an excitation signal
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
提供一种配置用于治疗脑组织的组织摧毁术治疗系统，其可包括任何数量的特征。在一个实施例中，该系统包括超声治疗换能器、引流导管以及设置在引流导管中的多个压电传感器。超声治疗被配置成将超声脉冲传输到脑部中以产生将脑部中的目标组织液化的空化。引流导管被构造为检测超声脉冲。系统可以基于由引流导管测量的超声脉冲来执行像差校正算法，以自动地校正由穿过患者的头盖骨的超声脉冲引起的像差效应。
Description
相关申请的交叉引用
本申请主张2015年6月24日提交的题为“用于治疗脑内出血的组织摧毁术治疗系统和方法(HISTOTRIPSY THERAPY SYSTEMS AND METHODS FOR THE TREATMENT OFINTRACEREBRAL HEMORRHAGE)”的美国临时专利申请第62/184,179号的权益，其通过引用被全文并入。
参考引用
此说明书中提及的所有出版物和专利申请均以引用的方式并入本文，其程度如同每个单独的出版物或专利申请被明确和单独地指出通过引用并入。
技术领域
本公开总体上涉及用超声疗法产生的空化来治疗组织。更明确地，本公开涉及用超声疗法治疗脑部组织或脑部疾病，例如脑内出血(ICH)或脑肿瘤。
背景技术
组织摧毁术、或脉冲超声空化疗法是声能的极短、剧烈爆发诱发焦点体积内受控的空化(微气泡形成)。这些微气泡的有力扩张和瓦解使在焦点体积内的细胞和组织结构机械地均匀化。这相比于热消融的凝固性坏死特性是非常不同的最终结果。为在非热性的组织摧毁术领域内操作，需要以低占空比的高振幅声脉冲的形式传递声能。
与传统的聚焦超声技术相比，组织摧毁术具有重要优势：1)焦点处的破坏过程是机械的，而非热的；2)气泡云在超声成像上显示明亮，从而确认正确的治疗靶向和定位；3)经治疗的组织在超声成像上显示较暗(低回声)，使得操作者知道哪些是经过治疗的；和4)组织摧毁术以受控且精确的方式制造损伤。重点强调的是，与微波、射频或高强度聚焦超声(HIFU)不同，组织摧毁术不是热模态。
脑部中血管的破裂会导致脑部内出血和凝血，术语被称为出血性中风或脑内出血(ICH)。ICH占据了所有中风的10-15％。当前的主流治疗仍然是开颅手术、一种高度侵入性的外科手术来去除凝块，伴随严重的脑神经功能的损伤。
已经研究了微创(MIS)立体定位方案，以用几天时间经由导管或溶血栓药物(tPA)来排出血肿。然而，tPA伴随有严重的并发症，并且ICH幸存者的功能结果仍未改善，这可能由于长时间的治疗使得神经损伤发展。
最近的临床前研究表明，使用磁共振引导的聚焦超声(MRgFUS)应用于头盖骨外，脑部中的凝块不用药物就能够被液化并用针吸出。然而，MRgFUS治疗时间仍不够短，从而避免神经损伤(40mL的凝块长达3小时)。由于需要的MRI时间长，所以花费高，并且不能治疗距离头盖骨2cm内的凝块。
超声路径上的头盖骨会引起经过头盖骨的超声信号的显著的衰减和散焦(像差作用)。为了校正像差，MRgFUS使用从患者脑部之前的三维CT扫描提取的头盖骨轮廓。然而，在MRgFUS治疗期间，不可能将患者放置在与前次扫描完全相同的位置，需要MRI来引导并监控穿过头盖骨的精确聚焦。该过程复杂且花费高。
此外，当前所有方法对大血肿(＞40mL)都无效。显然对于更好ICH治疗的需要未满足，该ICH治疗能够微创且快速地减少脑部内的血肿而无需tPA，这将使得ICH患者恢复健康免受明显的神经损伤。
发明内容
组织摧毁术通过由高压超声短脉冲产生的密集活力气泡云制造组织分离。当使用短于2个周期的脉冲时，这些活力的气泡云的产生仅取决于负压力峰值(P-)超过诱发介质中的空化的固有阈值(在含水量高的软组织中典型地为26-30MPa)的位置。
提供一种将超声能量传输到患者的脑部的方法，包括以下步骤：将引流导管放置在患者的脑部中的目标组织内、将治疗换能器的多个换能器元件的焦点定位在目标组织内、将超声脉冲从多个换能器元件中的每个换能器元件传输到目标组织中、用定位在引流导管上或引流导管内的一个或多个压电传感器检测超声脉冲、以及用像差校正算法基于所检测的超声脉冲调整超声脉冲从多个换能器元件的传输以自动地校正由透过患者的头盖骨的超声脉冲造成的像差效应。
在一个实施例中，目标组织包括凝块或血肿。在另一实施例中，目标组织包括脑肿瘤。
在另一实施例中，该方法还包括用超声脉冲在目标组织上形成气泡云。
在一些实施例中，该方法还包括用超声脉冲液化目标组织。
在另一实施例中，该方法包括用引流导管从脑部排出液化的目标组织。
在一个实施例中，用像差校正算法基于所检测的超声脉冲调整超声脉冲从多个换能器元件的传输还包括，确定超声脉冲从治疗换能器的多个换能器元件中的每个换能器元件行进到一个或多个压电传感器的传播时间、计算多个换能器元件中的每个换能器元件与治疗换能器的参考元件之间的传播时间延迟、以及基于所计算的时间延迟调整超声脉冲从多个换能器元件的传输。
在一个实施例中，一个或多个压电传感器包括第一压电传感器和第二压电传感器。在该实施例中，用像差校正算法基于所检测的超声脉冲调整超声脉冲从多个换能器元件的传输还包括，确定超声脉冲从治疗换能器的多个换能器元件中的每个换能器元件行进到第一压电传感器和第二压电传感器的传播时间、使用第一压电传感器和第二压电传感器在从多个换能器元件中的每个换能器元件到第一压电换能器与第二压电换能器的中点的射线上的投影计算第一压电传感器和第二压电传感器之间的距离、计算超声脉冲从多个换能器元件中的每个换能器元件到第一压电传感器和第二压电传感器的中点的行进方向和行进时间、计算多个换能器元件的每个换能器元件的焦点与中点之间的相隔距离(stand-off distance)、以及基于第一压电传感器与第二压电传感器之间的距离、中点和相隔距离计算多个换能器元件的每个换能器元件的时间延迟。
在一个实施例中，该方法包括将一个或多个压电传感器放置在焦点内或邻近焦点。在另一实施例中，放置步骤还包括使引流导管前进通过治疗换能器的孔。
在另一实施例中，该方法包括电子地或机械地使焦点移位，以完全液化目标组织。
还提供一种配置成治疗患者的脑部中的目标组织的超声系统，包括脉冲发生器和放大器；超声治疗换能器，其联接到脉冲发生器和放大器并且具有配置为穿过患者的头盖骨想脑部的目标组织内的聚焦点传输超声脉冲以产生空化的多个换能器元件；引流导管，包括一个或多个压电传感器，该引流导管适于被放置在脑部内靠近聚焦点以测量超声脉冲；电子控制器，与脉冲发生器、放大器、超声治疗换能器、和引流导管的压电传感器联接，该电子控制器被配置为控制超声脉冲的传输并基于引流导管所检测的超声脉冲执行像差算法来调整超声脉冲从多个换能器元件中的每一个换能器元件的传输，以自动地校正经过患者的头盖骨的超声脉冲引起的像差效应。
在一个实施例中，超声治疗换能器被配置为传输组织摧毁术治疗脉冲，以产生空化从而液化患者的脑部内的目标组织。
在另一实施例中，引流导管包括引流端口，其被构造为排出患者的被液化的目标组织。
在一些实施例中，一个或多个压电传感器确切地包括一个压电传感器。在该实施例中，像差校正算法包括确定超声脉冲从治疗换能器的多个换能器元件中的每个换能器元件行进到压电传感器的传播时间、计算多个换能器元件中的每个换能器元件与治疗换能器的参考元件之间的传播时间的时间延迟、以及基于计算的时间延迟调整超声脉冲从多个换能器元件的传输。
在一些实施例中，一个或多个压电传感器包括第一压电传感器和第二压电传感器。在该实施例中，像差校正算法包括确定超声脉冲从治疗换能器的多个换能器元件中每个换能器元件行进到第一压电传感器和第二压电传感器的传播时间、使用第一压电传感器和第二压电传感器在从多个换能器元件中的每个换能器元件到第一压电传感器和第二压电传感器的中点的射线上的投影来计算第一压电传感器与第二压电传感器之间的距离、计算超声脉冲从多个换能器元件中的每个换能器元件到第一压电传感器与第二压电传感器的中点的行进方向和行进时间、计算多个换能器传感器中每个换能器元件的焦点与中点之间的相隔距离、以及基于第一压电传感器与第二压电传感器之间的距离、中点和相隔距离计算多个换能器元件中的每个换能器元件的时间延迟。
在一个实施例中，治疗换能器包括孔，引流导管被构造为前进穿过该孔到患者的脑部中。
附图说明
在所附的权利要求书中具体阐述了本发明的新颖特征。通过参考以下详细描述来获得对本发明的特征和优点的更好的理解，其中阐述了利用本发明的原理的说明性实施例，在附图中：
图1示出了一种组织摧毁术治疗系统。
图2示出了具有微型压电传感器的引流导管和引导线的示意图。
图3示出了用于校正穿过头盖骨传播的超声脉冲的像差以实现穿过头盖骨的组织摧毁术疗法的聚焦的射线追踪算法。
图4-5示出了用组织摧毁术超声疗法来治疗脑组织的一个实施方案和方法。
具体实施方式
组织摧毁术是一种非侵入性的基于空化的治疗，其使用非常短的高压超声脉冲来产生密集的、高能的、产生损伤的气泡云。这种组织摧毁术治疗可以当靶向在液体-组织界面时产生受控的组织侵蚀，并且当其在大量组织中被靶向时可以产生划定好的组织分离。另外，已经显示组织摧毁术能够使用与常规冲击波碎石术(SWL)在机械性能方面不同的表面侵蚀来破碎模型肾结石。可以使用超声B型成像实时引导和监测组织摧毁术治疗，因为1)空化气泡云在B型成像中显示为时间上变化的高回声区，使得治疗可以精确地被靶向，并且2)靶向区域的回声随着组织分离程度的增加而降低，这可作为实时监测损伤产生(图像反馈)的一种方式。
一般而言，在组织摧毁术治疗中，施加具有一个或多个声周期的超声脉冲，并且气泡云的形成依赖于来自初始引发的稀疏分布的气泡(或一个气泡)的正激波阵面(有时超过100MPa，P+)的压力释放散射。这被称为“冲击散射机制”。这种机制取决于在换能器的焦点处以脉冲的初始负半周期开始的一个(或几个稀疏分布的)气泡。然后由于从这些稀疏地开始的高峰正激波阵面的压力释放向后散射而形成微气泡云。这些向后散射的高振幅稀疏波超过了固有的阈值，从而产生了局部密集的气泡云。每个接下来的声周期都会通过从朝向换能器生长的气泡云表面向后散射而诱发进一步的空化。结果，利用冲击散射机制观察到沿着与超声传播方向相反的声轴生长的细长密集气泡云。这种冲击散射过程使得气泡云的产生不仅取决于负峰压，还取决于声周期的数量和正冲击的幅度。如果没有这些由非线性传播产生的强烈的激波阵面，当高峰负半周期低于固有阈值时，不会产生密集的气泡云。
当施加小于2个周期的超声脉冲时，可以使冲击散射最小化，并且密集气泡云的产生取决于超过了介质的“固有阈值”(“固有阈值机制”)的所施加的超声脉冲的一个或两个负半周期。对于高含水量的软组织(如人体内的组织)，该阈值可以在26-30MPa范围内。使用这种固有阈值机制，损伤的空间范围是明确的和更可预测的。在负峰压(P-)没有显着高于该阈值的情况下，可以产生与换能器的-6dB波束宽度的一半一样小的亚波长可再现损伤。
组织摧毁术能克服常规ICH治疗的缺点，以提供脑内血肿的微创的快速的减少，无需溶血栓药物，也不管血肿的大小如何。本文描述的系统和方法在高压下传输微秒长度的超声脉冲，以使用焦点区域内凝块中的预先存在的气体核来产生密集的微气泡的空化云。微气泡的迅速扩张和瓦解诱发对邻近细胞的高应变和应力以将细胞分离成液状的无细胞匀浆。
根据一些实施例，组织摧毁术可以用于治疗脑组织或脑部疾病，例如ICH或脑肿瘤。在一个实施方案中，可以使用组织摧毁术穿过患者的头盖骨使凝块或脑肿瘤液化，然后可以通过引流导管排出产生的液体，而不使用溶血栓药物或外用剂。例如，在30分钟内可使用组织摧毁术穿过人的头盖骨将40mL的体外凝块液化，这比MRgFUS快六倍。通过参数优化，与MRgFUS相比，治疗时间可以缩短一个数量级以上。这些优化的参数可以用于治疗大于40mL和在距头盖骨2cm内的位置的凝块。本文所述的系统和方法使得即使对于>40mL的凝块也能以微创方法快速除去凝块，并且不需要溶血栓药物和MRI，从而显著改善ICH和脑肿瘤治疗。
根据本文描述的使用组织摧毁术来治疗脑部的实施例，导管可以被放置在目标组织中，例如患者的脑部内的凝块或肿瘤中。一个或多个声学水诊器或PZT传感器可以集成于放置在导管内的引导线，其随后可以被插入到脑部内的目标组织中，以直接测量来自位于患者体外的组织摧毁术治疗换能器的超声信号。组织摧毁术治疗换能器的所有元件的脉冲传输的时机可以被重新调整，以通过利用在传感器处从组织摧毁术治疗换能器的每个元件接收的超声信号的时机来穿过头盖骨重新聚焦。本文描述的用于经颅组织摧毁术治疗的传感器和相关的像差校正算法是新颖的，并且可以提供成本低廉且简化的装置，以在没有CT或MRI的情况下引导和监测经颅组织摧毁术治疗。
图1示出了根据本文所述的方法和实施例的被配置为在组织中产生空化气泡或气泡云的组织摧毁术系统。组织摧毁术系统和发生器被配置为生成复杂的波形，以支持本文所述的超声脉冲序列。系统100的简化框图在图1中示出。系统的主要部件是：计算机/控制器102、USB到串行转换器104、FPGA(现场可编程门阵列)108、高压控制器和电源110、放大器112和治疗换能器114以及引流导管117。
对于发生器的所有控制可以使用可在计算机/控制器102(例如，标准PC、膝上型计算机、平板电脑或其他电子计算系统)上运行的“组织摧毁术服务工具(HistotripsyService Tool)”软件来建立，并且经由诸如无线、USB或串行通信104的连接器与发生器通信。控制器102可以包括被配置为存储能够由控制器执行的一组指令的非暂时性计算机可读存储介质。
系统100可以被配置成接收多组不同的驱动参数并将它们循环，这使得用户能够创建宽范围的定制序列，其中所有参数(脉冲重复频率(PRF)、电压幅度、周期的次数、每组脉冲数、频率、启用的换能器元件通道、以及时间延迟)可以针对每个生成的脉冲设定为不同的值。脉冲之间的时间延迟可由PRF指定参数组或通过逐个脉冲手动/单独地指定它们。
对于整体电压幅度调节，高电压电平可以通过HV控制器110相应地改变。该方法不能用于两个脉冲之间的动态电压幅度变化，因为HV线上的所有电容器将花费太长时间放电。对于脉冲之间的动态电压幅度变化，可以在FPGA 108处使用PWM(脉宽调制)，其中电容器充电脉冲的占空比可以被调制以产生期望的脉冲电压和合成的压力幅度。
USB到串行转换器
USB到串行转换器104可以将USB组合转换为串行，以便从PC或电子控制器到FPGA进行通信。应该理解的是，在发生器和控制器之间的连接不是USB连接的实施例中，可以使用其它转换器(或根本不使用)。
FPGA
FPGA 108从PC或电子控制器102接收信息，并且可以产生为了驱动放大器112所需的复杂脉冲序列。FPGA可以在100MHz时钟上运行，因为关键是使脉冲的速度以至少10ns的增量定时。
高压控制器和电源
高压控制器和电源110确定需要提供给放大器电路的DC电压的电平，以便在放大器的输出处具有足够的电压幅度水平。
放大器
放大器112接收由FPGA产生的脉冲，并由高压控制器和电源供应高电压。它产生通过使治疗换能器的阻抗与放大器的阻抗适当地匹配的匹配网络部件被馈送到治疗换能器114的高电压幅度脉冲。可能需要使用大量电容器，这些电容器可以存储足够的能量以在高电压幅度脉冲的产生期间支持峰值电流需求。
治疗换能器
治疗换能器114可以是单元件换能器或多元件超声治疗换能器，其包括多个换能器元件并且被配置成生成并传递本文所述的超声治疗脉冲至组织或其他介质中。在一些实施例中，多元件超声治疗换能器可以产生两个或更多个频率的超声脉冲。治疗换能器的有源换能器元件可以是压电换能器元件。在一些实施例中，换能器元件可以以共同的几何焦点安装至声学透镜。
在其他实施例中，换能器元件可以包括相控阵列，该相控阵列利用移位参数进行优化，以最大化经颅组织摧毁术凝块液化的治疗速度和位置，而不使头盖骨过热。头盖骨过热是制约经颅超声治疗的治疗速度和位置的主要限制。建议的参数优化将确保快速脑组织治疗并最小化对头盖骨的加热。在一些实施例中，治疗换能器可以实现大于1mL/min的脑组织液化速率，其比被动溶栓作用快几个数量级。
治疗换能器可以被配置为以具有持续大约1-4μs的一个高负压相位的单个超声脉冲穿过头盖骨产生空化，其中脉冲的负峰压直接超过用于介质的空化的“固有阈值”(对于脑组织如凝块约27MPa)。治疗换能器的焦点可以被电动地移位到其他位置，以覆盖大的治疗体积，并且与其他治疗形式相比，治疗时间可以缩短超过一个数量级。在一些实施例中，焦点移位速率可以保持在1％占空比以下，以避免头盖骨过热。
根据本文所述的系统和方法，可以在没有实时成像的情况下执行组织摧毁术脑部治疗。CT扫描可能需要作为目标组织诊断的一部分，但是在治疗之前进行。使用事先的CT扫描和立体定位方法，可以将引流水诊器放置在凝块内，并且导管尖端相对于凝块位置的准确位置是已知的。然后可以使来自组织摧毁术治疗换能器的焦点移位来液化大部分的脑组织，留下组织的薄的边缘以避免对邻近的脑组织造成损伤。
引流导管
图2是系统的引流导管117的放大图，其可以包括护套部分118和引导线部分120。护套部分可以包括柔性材料并且可以包括一个或多个引流口119，以有利于通过导管移除体液或组织。引导线部分120可以被插入护套部分118中以将导管移位至组织中的目标区域。引流导管可以还包括沿引导线部分120设置的一个或多个压电(PZT)传感器122。图2的实施例示出了2个PZT传感器，但是应该理解，可以实现任何数量的PZT传感器。例如，一些实施例使用单个PZT传感器。导管的PZT传感器可以被配置为测量来自治疗换能器114的各个元件的超声脉冲波形，以提取由治疗换能器传输的波形之间的时间延迟。时间延迟随后可以由系统用于像差校正。
另外，PZT传感器也可以用于监测空化的发生和维持，空化是成功进行组织摧毁术治疗的标志，并且可以随着来自空化部位的增加的声发射而进行监测。因为由头盖骨引起的衰减因人而异，所以这种实时空化检测可以用于确定为各个患者启动空化所需的功率。
软件和硬件可以被配置为相继地自动控制来自治疗换能器的每个元件的脉冲传输，并且收集和存储来自PZT传感器的信号。通过一次传输来自一个元件的单个脉冲只需要几微秒的时间并且超声从该元件行进到水诊器需要大约100μs的时间，整个数据采集可以使用自动化封装在一秒钟内快速完成。
组织摧毁术服务工具和电子控制器
组织摧毁术服务工具是可以在任何PC或计算系统(例如，电子控制器)上运行并且可以用于控制系统的软件。组织摧毁术服务工具可以用治疗换能器启动/停止治疗，设置并读取高电压电平、治疗参数(PRF、周期数、占空比、通道启用和延迟等)，以及设置和读取其他服务及维护相关的项目。组织摧毁术服务工具和电子控制器可配置为设置/读取工作参数，启动/停止治疗等。它可以使用内部闪存或其他电子存储介质来存储所有参数。组织摧毁术服务工具和电子控制器可以与FPGA 108进行生成复杂脉冲所需的所有驱动参数的通信。它们还可以使用串行通信或其他电子通信方式与高电压控制器和电源110进行通信，在高电压控制器和电源110处可以设置/读取驱动电压的适当电平。
组织摧毁术服务工具和电子控制器可以联接到治疗换能器和引流导管的PZT传感器，以在经颅组织摧毁术治疗期间使用来自引流导管的反馈。当超声脉冲穿过人的头盖骨传播时，像差效应导致超声脉冲的负峰压降低。在一些实验中，已显示头盖骨的像差效应将负峰压降低至脉冲的自由场条件的约20％或更少。
在一个实施例中，引流导管的PZT传感器可以测量来自治疗换能器的每个换能器元件的超声脉冲信号，并且组织摧毁术服务工具和电子控制可以使用这些测量并执行像差校正算法以调整对每个换能器元件的电脉冲的时机，以校正像差效应。然后软件和硬件可以相继地自动控制每个元件的脉冲传输，并收集和存储测量的信号。通过一次传输来自一个元件的单个脉冲只需要几微秒的时间并且超声从每个元件行进到PZT传感器的时间只需要100μs，整个数据采集可以使用所提出的自动化封装在一秒钟内完成。
基于射线追踪的像差校正算法被配置为处理来自PZT传感器的测量的信号，以实现治疗换能器穿过头盖骨的精确聚焦和电或机械焦点移位。在下面描述的具体实施例中，该系统可以包括两个或更多个PZT传感器。该算法包含三个步骤，如图3所示。步骤如下：1)使用导管(H1、H2)内的两个或更多个PZT传感器和治疗换能器的发射换能器元件(TN)的已知位置定义平面ΠN，射线的行进方向被限制在该平面上。假定H1和H2距离TN足够远，使得来自每个单独元件的发射的信号作为平面波有效地行进。超声从TN行进到H1和H2的传播时间(t1和t2)可以基于信号到达PZT传感器与其从换能器元件传输之间的时间间隔来计算。使用Δt＝t1-t2，计算dN1和dN2之间的距离为dist(dN1-dN2)＝ctissue*Δt，其中dN1和dN2是H1和H2在从TN到两个传感器中点Hmid的射线上的投影。然后可以计算出波从TN到Hmid的行进方向θi和行进时间。2)知道θi，可以定义与该波传播正交的平面Πorth，并且其中心在Hmid处。然后假定平面波传播，通过计算Πorth和fn之间的相隔距离dx并且插入等式T(fn)＝tmid+dx/ctissue中，可以计算给定焦点位置fn的每个换能器元件的必要时间延迟。3)基于对于治疗体积内所有移位位置所计算的时间延迟，可以在软件中生成移位模式。该软件可以配置为控制移位参数和空化监测，并且可以包含像差校正算法，以自动收集和处理PZT传感器信号并产生调整后的移位模式。
在一个实施例中，基于时间延迟的像差校正算法被用于实现治疗换能器穿过头盖骨的精确聚焦以及电或机械的焦点移位。在下面直接描述的具体实施例中，可以使用单个PZT传感器。根据该实施例，算法包括确定超声脉冲从治疗换能器的多个换能器元件中的每一个行进到压电传感器的传播时间，计算多个换能器元件中的每一个与治疗换能器的参考元件之间的传播时间的时间延迟，并且基于所计算的时间延迟调整来自多个换能器元件的超声脉冲的传输。
超声经颅治疗的一个限制是对头盖骨过热。为了解决这个问题，除了参数优化之外还可以采用多种策略。某些元素被点燃的顺序可以是交替的以减少由个别元素引起的局部发热。通过使用冷水作为对于头盖骨的超声耦合介质，也可以减少热量。
图4-5示出了用组织摧毁术超声治疗来治疗脑组织的一个实施方案和方法。图4示出了邻近患者的头盖骨放置的治疗换能器114和部分位于患者的脑部内的引流导管117，使得导管的引流端口位于脑部的目标组织(如血凝块或脑肿瘤)内或在其附近。为了获得精确的聚焦和焦点移位，导管中的PZT传感器可以靠近换能器的几何焦点放置。在一个实施例中，治疗换能器114可以包括孔123，以便导管穿过换能器阵列插入。导管架可以拧入孔中，在导管上标记有刻度，这使得操作者能够基于插入位置、角度和距离知道导管尖端的准确位置。
首先，参考图5的步骤50以及图4，引流导管117可以插入穿过患者的头盖骨，并且放置在脑部内的目标组织内或在其附近。接下来，参考图5的步骤52以及图4，可以将治疗换能器114的焦点定位在目标组织上。治疗换能器本身可以声学联接到患者的颅骨。接下来，参照图5的步骤54，超声脉冲可以从治疗换能器传输到目标组织中。在图5的步骤56中，引流导管的PZT传感器可以检测或测量来自治疗换能器的超声脉冲。最后，在图5的步骤58中，系统的软件和电子控制器可以基于来自PZT传感器的测量结果用像差校正算法来调整超声脉冲的时机，以校正由头盖骨引起的像差效应。
超声脉冲可被配置成在脑部的目标组织内产生空化或气泡云以液化目标组织。在一些实施例中，液化的目标组织可以用导管排出。在进一步的实施例中，治疗换能器的焦点可以被电子地或机械地移位以完全液化目标组织。
本文包括的示例和说明通过说明而非限制的方式示出了可以实践的主题的具体实施例。如上所述，其他实施例可以利用并从中导出，使得可以在不脱离本公开的范围的情况下进行结构和逻辑上的替换和改变。本发明主题的这些实施例在本文中可以单独地或共同地指代术语“发明”，这仅仅是为了方便而并非意图将本申请的范围自愿地限制到任何单个的发明或发明构思，如果事实上多于一个被披露。因此，尽管本文已经说明和描述了具体的实施例，但是为了实现相同的目的而推导的任何布置都可以代替所示的具体实施例。本公开旨在覆盖各种实施例的任何和所有的修改或变化。上述实施例的组合以及本文中未具体描述的其他实施例在阅读以上描述时对于本领域技术人员而言将是显而易见。
Claims (21)
1.一种将超声能量传输到患者的脑部中的方法，包括以下步骤：
将引流导管放置在所述患者的脑部中的目标组织内；
将治疗换能器的多个换能器元件的焦点定位在所述目标组织内；
将超声脉冲从所述多个换能器元件中的每个换能器元件传输到所述目标组织中；
用定位在所述引流导管上或所述引流导管中的一个或多个压电传感器检测所述超声脉冲；和
用像差校正算法基于所检测的超声脉冲调整超声脉冲从所述多个换能器元件的传输，以自动地校正由透过所述患者的头盖骨的超声脉冲引起的像差效应。
2.如权利要求1所述的方法，其中所述目标组织包括凝块或血肿。
3.如权利要求1所述的方法，其中所述目标组织包括脑肿瘤。
4.如权利要求1所述的方法，还包括用所述超声脉冲在所述目标组织上形成气泡云。
5.如权利要求1所述的方法，还包括用所述超声脉冲液化所述目标组织。
6.如权利要求5所述的方法，还包括用所述引流导管从所述脑部排出液化的目标组织。
7.如权利要求1所述的方法，其中用所述像差校正算法基于所检测的超声脉冲调整超声脉冲从所述多个换能器元件的传输还包括：
确定所述超声脉冲从所述治疗换能器的多个换能器元件中的每个换能器元件行进到一个或多个压电传感器的传播时间；
计算所述多个换能器元件中的每个换能器元件与所述治疗换能器的参考元件之间的传播时间的时间延迟；和
基于所计算的时间延迟调整超声脉冲从所述多个换能器元件的传输。
8.如权利要求1所述的方法，其中所述一个或多个压电传感器包括第一压电传感器和第二压电传感器。
9.根据权利要求8所述的方法，其中用所述像差校正算法基于所检测的超声脉冲利调整超声脉冲从所述多个换能器元件的传输还包括：
确定超声脉冲从所述治疗换能器的多个换能器元件中的每个换能器元件行进到所述第一压电传感器和第二压电传感器的传播时间；
使用所述第一压电传感器和所述第二压电传感器在从所述多个换能器元件中的每个换能器元件到所述第一压电传感器与所述第二压电传感器的中点的射线上的投影，计算所述第一压电传感器与第二压电传感器之间的距离；
计算所述超声脉冲从所述多个换能器元件中的每个换能器元件到所述第一压电传感器和第二压电传感器的中点的的行进方向和行进时间；
计算所述多个换能器元件中的每个换能器元件的焦点与所述中点之间的相隔距离；和
基于所述第一压电传感器和第二压电传感器之间的距离、所述中点和所述相隔距离来计算所述多个换能器元件中的每个换能器元件的时间延迟。
10.如权利要求1所述的方法，还包括将所述一个或多个压电传感器放置在所述焦点内或与所述焦点相邻。
11.如权利要求1所述的方法，其中所述放置步骤还包括使所述引流导管前进通过所述治疗换能器的孔。
12.根据权利要求5所述的方法，还包括电子地移位所述焦点以完全液化所述目标组织。
13.如权利要求5所述的方法，还包括机械地移位所述焦点以完全液化所述目标组织。
14.一种配置成治疗患者的脑部中的目标组织的超声系统，包括：
脉冲发生器和放大器；
超声治疗换能器，其联接到所述脉冲发生器并且具有多个换能器元件，所述多个换能器元件被配置成将超声脉冲穿过患者的头盖骨朝向所述脑部中的所述目标组织内的聚焦点传输以产生空化；
引流导管，包括一个或多个压电传感器，所述引流导管适于被放置在所述脑部内所述聚焦点附近，以测量所述超声脉冲；
电子控制器，与所述脉冲发生器、所述超声治疗换能器、以及所述引流导管的压电传感器联接，所述电子控制器被配置为控制所述超声脉冲的传输并且基于由所述引流导管所检测的超声脉冲执行像差校正算法来调整超声脉冲从所述多个换能器元件中的每个换能器元件的发射，以自动地校正由透过所述患者的头盖骨的超声脉冲引起的像差效应。
15.如权利要求14所述的超声系统，其中所述超声治疗换能器被配置成传输组织摧毁术治疗脉冲，以产生空化从而液化所述患者的脑部内的目标组织。
16.如权利要求15所述的超声系统，所述引流导管包括构造成排出所述患者的液化的目标组织的引流端口。
17.如权利要求14所述的超声系统，其中所述一个或多个压电传感器确切地包括一个压电传感器。
18.如权利要求17所述的超声系统，其中所述像差校正算法包括：
确定所述超声脉冲从所述治疗换能器的多个换能器元件中的每个换能器元件行进到压电传感器的传播时间；
计算所述多个换能器元件中的每个换能器元件与所述治疗换能器的参考元件之间的传播时间的时间延迟；和
基于所计算的时间延迟来调整超声脉冲从所述多个换能器元件的传输。
19.如权利要求14所述的超声系统，其中，所述一个或多个压电传感器包括第一压电传感器和第二压电传感器。
20.如权利要求19所述的超声系统，其中所述像差校正算法包括：
确定所述超声脉冲从所述治疗换能器的多个换能器元件中的每个换能器元件行进到所述第一压电传感器和第二压电传感器的传播时间；
使用所述第一压电传感器和所述第二压电传感器在从所述多个换能器元件中的每个换能器元件到所述第一压电传感器与所述第二压电传感器的中点的射线上的投影，来计算所述第一压电传感器与第二压电传感器之间的距离；
计算所述超声脉冲从所述多个换能器元件中的每个换能器元件到所述第一压电传感器与第二压电传感器的中点的行进方向和行进时间；
计算所述多个换能器元件中的每个换能器元件的焦点与所述中点之间的相隔距离；和
基于所述第一压电传感器和第二压电传感器之间的距离、所述中点和所述相隔距离来计算所述多个换能器元件中的每个换能器元件的时间延迟。
21.如权利要求14所述的超声系统，其中所述治疗换能器包括孔，所述引流导管被构造成前进穿过所述孔到所述患者的脑部中。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562184179P | 2015-06-24 | 2015-06-24 | |
| US62/184,179 | 2015-06-24 | ||
| PCT/US2016/039020 WO2016210133A1 (en) | 2015-06-24 | 2016-06-23 | Histotripsy therapy systems and methods for the treatment of brain tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108348772A true CN108348772A (zh) | 2018-07-31 |
| CN108348772B CN108348772B (zh) | 2020-03-03 |
Family
ID=57586419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680045860.4A Active CN108348772B (zh) | 2015-06-24 | 2016-06-23 | 用于治疗脑组织的组织摧毁术治疗系统和方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11135454B2 (zh) |
| EP (2) | EP3313517B1 (zh) |
| JP (1) | JP6979882B2 (zh) |
| CN (1) | CN108348772B (zh) |
| ES (1) | ES2948135T3 (zh) |
| HK (1) | HK1257321A1 (zh) |
| WO (1) | WO2016210133A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171156A (zh) * | 2021-04-23 | 2021-07-27 | 清华大学 | 植入式医疗器械的超声除栓配件 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10219815B2 (en) | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| US20140100459A1 (en) | 2012-10-05 | 2014-04-10 | The Regents Of The University Of Michigan | Bubble-induced color doppler feedback during histotripsy |
| US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| CA3073552A1 (en) | 2017-09-01 | 2019-03-07 | Dalhousie University | Transducer assembly for generating focused ultrasound |
| KR102124422B1 (ko) | 2018-06-05 | 2020-06-18 | 한국과학기술연구원 | 고강도-저강도 집속초음파 치료장치 |
| KR102118713B1 (ko) * | 2018-08-14 | 2020-06-04 | 광운대학교 산학협력단 | 뇌 질환 치료를 위한 Ｆ-ＴＦＴＡ를 사용한 다채널 ＥＣｏＧ 전극과 뇌파 수집 센서를 구비하는 무선 송수신 의료기기 |
| WO2020113083A1 (en) | 2018-11-28 | 2020-06-04 | Histosonics, Inc. | Histotripsy systems and methods |
| CA3164003A1 (en) * | 2020-01-07 | 2021-07-15 | Zhen Xu | Systems and methods for robotically-assisted histotripsy targeting based on mri/ct scans taken prior to treatment |
| JP2023513012A (ja) | 2020-01-28 | 2023-03-30 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | ヒストトリプシー免疫感作のためのシステムおよび方法 |
| US20230017864A1 (en) * | 2021-07-19 | 2023-01-19 | The Cleveland Clinic Foundation | Systems and methods for use with mri-guided focused ultrasound |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732031A (zh) * | 2002-12-23 | 2006-02-08 | 因赛泰克-特克斯索尼克斯公司 | 超声波治疗中的组织偏差校正 |
| US20060173387A1 (en) * | 2004-12-10 | 2006-08-03 | Douglas Hansmann | Externally enhanced ultrasonic therapy |
| CN201197744Y (zh) * | 2008-01-30 | 2009-02-25 | 贾红 | 大鼠脑核团定位损毁仪 |
| CN102292123A (zh) * | 2008-11-19 | 2011-12-21 | 因赛泰克有限公司 | 闭环凝块消散 |
| CN102665585A (zh) * | 2009-10-09 | 2012-09-12 | 伊西康内外科公司 | 用于超声装置和用于电外科装置的外科发生器 |
| CN103537016A (zh) * | 2012-07-13 | 2014-01-29 | 重庆融海超声医学工程研究中心有限公司 | 超声换能器焦点的校正方法、装置及超声治疗设备 |
| CN103648361A (zh) * | 2011-05-13 | 2014-03-19 | 直观外科手术操作公司 | 提供用于图像引导的外科手术的解剖结构的模型的动态配准的医疗系统 |
| CN103812477A (zh) * | 2012-11-12 | 2014-05-21 | 财团法人工业技术研究院 | 超声波发射电路及其时间延迟校正方法 |
| CN104013444A (zh) * | 2014-06-23 | 2014-09-03 | 南京广慈医疗科技有限公司 | 一种相控阵高强度聚焦超声消融系统 |
| CN104135938A (zh) * | 2012-02-23 | 2014-11-05 | 日立阿洛卡医疗株式会社 | 超声波诊断装置和超声波探头 |
Family Cites Families (487)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3243497A (en) | 1964-12-11 | 1966-03-29 | Dynapower Systems Corp Of Cali | Universal support for electrotherapeutic treatment head |
| US3679021A (en) | 1970-03-25 | 1972-07-25 | Eg & G Inc | Acoustic pulse generating system |
| US3879699A (en) | 1973-04-26 | 1975-04-22 | Edo Corp | Unipolar acoustic pulse generator apparatus |
| US4016749A (en) | 1973-07-05 | 1977-04-12 | Wachter William J | Method and apparatus for inspection of nuclear fuel rods |
| FR2355288A2 (fr) | 1974-11-28 | 1978-01-13 | Anvar | Perfectionnements aux procedes et dispositifs de sondage par ultra-sons |
| US4024501A (en) | 1975-09-03 | 1977-05-17 | Standard Oil Company | Line driver system |
| US4051394A (en) | 1976-03-15 | 1977-09-27 | The Boeing Company | Zero crossing ac relay control circuit |
| US4277367A (en) | 1978-10-23 | 1981-07-07 | Wisconsin Alumni Research Foundation | Phantom material and method |
| GB2048478A (en) | 1979-03-20 | 1980-12-10 | Gen Electric Co Ltd | Ultrasonic imaging system |
| US4406153A (en) | 1979-05-04 | 1983-09-27 | Acoustic Standards Corporation | Ultrasonic beam characterization device |
| US4266747A (en) | 1979-07-26 | 1981-05-12 | Positioning Devices, Incorporated | Equipoised articulated support arm |
| US4269174A (en) | 1979-08-06 | 1981-05-26 | Medical Dynamics, Inc. | Transcutaneous vasectomy apparatus and method |
| FR2472753A1 (fr) | 1979-12-31 | 1981-07-03 | Anvar | Perfectionnements aux dispositifs de sondage par ultra-sons |
| US4305296B2 (en) | 1980-02-08 | 1989-05-09 | Ultrasonic imaging method and apparatus with electronic beam focusing and scanning | |
| JPS5711648A (en) | 1980-06-27 | 1982-01-21 | Matsushita Electric Ind Co Ltd | Ultrasonic probe |
| US4453408A (en) | 1981-03-09 | 1984-06-12 | William Clayman | Device for testing ultrasonic beam profiles |
| US4447031A (en) | 1981-04-13 | 1984-05-08 | Positioning Devices, Inc. | Spring counterbalanced support arm system |
| US4548374A (en) | 1981-08-07 | 1985-10-22 | General Electric Company | Ultrasonic scanning apparatus and positioning system |
| JPS5826238A (ja) | 1981-08-08 | 1983-02-16 | Fujitsu Ltd | 超音波による圧力測定方式 |
| US4622972A (en) | 1981-10-05 | 1986-11-18 | Varian Associates, Inc. | Ultrasound hyperthermia applicator with variable coherence by multi-spiral focusing |
| DE3220751A1 (de) | 1982-06-02 | 1983-12-08 | Jörg Dr. 8022 Grünwald Schüller | Vorrichtung zur zertruemmerung von konkrementen, insbesondere von nierensteinen, im lebenden menschlichen oder tierischen koerper |
| US4550606A (en) | 1982-09-28 | 1985-11-05 | Cornell Research Foundation, Inc. | Ultrasonic transducer array with controlled excitation pattern |
| SE442052B (sv) | 1983-09-21 | 1985-11-25 | Sven Sandell | Imiterat levande ljus med langstreckt ljuskropp |
| JPS6080779A (ja) | 1983-10-07 | 1985-05-08 | Matsushita Electric Ind Co Ltd | 磁界センサ |
| USRE33590E (en) | 1983-12-14 | 1991-05-21 | Edap International, S.A. | Method for examining, localizing and treating with ultrasound |
| US5150711A (en) | 1983-12-14 | 1992-09-29 | Edap International, S.A. | Ultra-high-speed extracorporeal ultrasound hyperthermia treatment device |
| US5158070A (en) | 1983-12-14 | 1992-10-27 | Edap International, S.A. | Method for the localized destruction of soft structures using negative pressure elastic waves |
| US5143074A (en) | 1983-12-14 | 1992-09-01 | Edap International | Ultrasonic treatment device using a focussing and oscillating piezoelectric element |
| US5143073A (en) | 1983-12-14 | 1992-09-01 | Edap International, S.A. | Wave apparatus system |
| US4549533A (en) | 1984-01-30 | 1985-10-29 | University Of Illinois | Apparatus and method for generating and directing ultrasound |
| US4641378A (en) | 1984-06-06 | 1987-02-03 | Raycom Systems, Inc. | Fiber optic communication module |
| DE3425705A1 (de) | 1984-07-12 | 1986-01-16 | Siemens AG, 1000 Berlin und 8000 München | Phased-array-geraet |
| DE3427001C1 (de) | 1984-07-21 | 1986-02-06 | Dornier System Gmbh, 7990 Friedrichshafen | Ortungs- und Positioniervorrichtung |
| US4575330A (en) | 1984-08-08 | 1986-03-11 | Uvp, Inc. | Apparatus for production of three-dimensional objects by stereolithography |
| US4625731A (en) | 1984-10-10 | 1986-12-02 | Picker International, Inc. | Ultrasonic image display mounting |
| US5431621A (en) | 1984-11-26 | 1995-07-11 | Edap International | Process and device of an anatomic anomaly by means of elastic waves, with tracking of the target and automatic triggering of the shootings |
| JPS61196718A (ja) | 1985-02-22 | 1986-08-30 | 株式会社日立製作所 | 地絡保護装置 |
| US4689986A (en) | 1985-03-13 | 1987-09-01 | The University Of Michigan | Variable frequency gas-bubble-manipulating apparatus and method |
| JPS61209643A (ja) | 1985-03-15 | 1986-09-17 | 株式会社東芝 | 超音波診断治療装置 |
| US4865042A (en) | 1985-08-16 | 1989-09-12 | Hitachi, Ltd. | Ultrasonic irradiation system |
| EP0215972B1 (de) | 1985-09-24 | 1990-12-05 | Hewlett-Packard GmbH | Schaltmatrix |
| DE3544628A1 (de) | 1985-12-17 | 1987-06-19 | Eisenmenger Wolfgang | Einrichtung zur mechanisch akustischen ankopplung von druckwellen, insbesondere von fokussierten stosswellen an den koerper von lebewesen |
| DE3607949A1 (de) | 1986-03-11 | 1987-09-17 | Wolf Gmbh Richard | Verfahren zum erkennen von moeglichen gewebeschaedigungen bei der medizinischen anwendung von hochenergie-schall |
| US4791915A (en) | 1986-09-29 | 1988-12-20 | Dynawave Corporation | Ultrasound therapy device |
| US4984575A (en) | 1987-04-16 | 1991-01-15 | Olympus Optical Co., Ltd. | Therapeutical apparatus of extracorporeal type |
| FR2614722B1 (fr) | 1987-04-28 | 1992-04-17 | Dory Jacques | Filtre acoustique permettant de supprimer ou d'attenuer les alternances negatives d'une onde elastique et generateur d'ondes elastiques comportant un tel filtre |
| FR2614747B1 (fr) | 1987-04-28 | 1989-07-28 | Dory Jacques | Generateur d'impulsions elastiques ayant une forme d'onde predeterminee desiree et son application au traitement ou au diagnostic medical |
| FR2619448B1 (fr) | 1987-08-14 | 1990-01-19 | Edap Int | Procede et dispositif de caracterisation tissulaire par reflexion d'impulsions ultrasonores a large bande de frequences, transposition du spectre de frequence des echos dans une gamme audible et diagnostic par ecoute |
| US4973980A (en) | 1987-09-11 | 1990-11-27 | Dataproducts Corporation | Acoustic microstreaming in an ink jet apparatus |
| DE3732131A1 (de) | 1987-09-24 | 1989-04-06 | Wolf Gmbh Richard | Fokussierender ultraschallwandler |
| DE3741201A1 (de) | 1987-12-02 | 1989-06-15 | Schering Ag | Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung |
| US4989143A (en) | 1987-12-11 | 1991-01-29 | General Electric Company | Adaptive coherent energy beam formation using iterative phase conjugation |
| US5163421A (en) | 1988-01-22 | 1992-11-17 | Angiosonics, Inc. | In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging |
| US4957099A (en) | 1988-02-10 | 1990-09-18 | Siemens Aktiengesellschaft | Shock wave source for extracorporeal lithotripsy |
| US5209221A (en) | 1988-03-01 | 1993-05-11 | Richard Wolf Gmbh | Ultrasonic treatment of pathological tissue |
| DE3808783A1 (de) | 1988-03-16 | 1989-10-05 | Dornier Medizintechnik | Steinzerkleinerung durch kombinierte behandlung |
| DE3817094A1 (de) | 1988-04-18 | 1989-11-30 | Schubert Werner | Ankopplungs- und haftvorrichtung fuer stosswellenbehandlungsgeraete |
| US4938217A (en) | 1988-06-21 | 1990-07-03 | Massachusetts Institute Of Technology | Electronically-controlled variable focus ultrasound hyperthermia system |
| US5158071A (en) | 1988-07-01 | 1992-10-27 | Hitachi, Ltd. | Ultrasonic apparatus for therapeutical use |
| DE68915935T2 (de) | 1988-10-26 | 1994-11-03 | Toshiba Kawasaki Kk | Gerät zur Stosswellen-Behandlung. |
| FR2642640B1 (fr) | 1989-02-08 | 1991-05-10 | Centre Nat Rech Scient | Procede et dispositif de focalisation d'ultrasons dans les tissus |
| JPH02217000A (ja) | 1989-02-16 | 1990-08-29 | Hitachi Ltd | 超音波探触子 |
| JP2694992B2 (ja) | 1989-02-17 | 1997-12-24 | 株式会社東芝 | 結石破砕装置 |
| FR2643252B1 (fr) | 1989-02-21 | 1991-06-07 | Technomed Int Sa | Appareil de destruction selective de cellules incluant les tissus mous et les os a l'interieur du corps d'un etre vivant par implosion de bulles de gaz |
| US5435311A (en) | 1989-06-27 | 1995-07-25 | Hitachi, Ltd. | Ultrasound therapeutic system |
| US5065761A (en) | 1989-07-12 | 1991-11-19 | Diasonics, Inc. | Lithotripsy system |
| US5014686A (en) | 1989-08-31 | 1991-05-14 | International Sonic Technologies | Phantom kidney stone system |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5065751A (en) | 1990-01-03 | 1991-11-19 | Wolf Gerald L | Method and apparatus for reversibly occluding a biological tube |
| US5165412A (en) | 1990-03-05 | 1992-11-24 | Kabushiki Kaisha Toshiba | Shock wave medical treatment apparatus with exchangeable imaging ultrasonic wave probe |
| JPH0422351A (ja) * | 1990-05-17 | 1992-01-27 | Olympus Optical Co Ltd | 溶解治療装置 |
| US5091893A (en) | 1990-04-05 | 1992-02-25 | General Electric Company | Ultrasonic array with a high density of electrical connections |
| DE4012760A1 (de) | 1990-04-21 | 1992-05-07 | G M T I Ges Fuer Medizintechni | Ultraschall-doppler-verfahren zur bestimmung der steingroesse aus der sinkgeschwindigkeit waehrend der gallen-lithotripsie sowie vorrichtung zur durchfuehrung des verfahrens |
| US5215680A (en) | 1990-07-10 | 1993-06-01 | Cavitation-Control Technology, Inc. | Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles |
| US6344489B1 (en) | 1991-02-14 | 2002-02-05 | Wayne State University | Stabilized gas-enriched and gas-supersaturated liquids |
| US5316000A (en) | 1991-03-05 | 1994-05-31 | Technomed International (Societe Anonyme) | Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy |
| US5450305A (en) | 1991-08-12 | 1995-09-12 | Auckland Uniservices Limited | Resonant power supplies |
| US5524620A (en) | 1991-11-12 | 1996-06-11 | November Technologies Ltd. | Ablation of blood thrombi by means of acoustic energy |
| US5601526A (en) | 1991-12-20 | 1997-02-11 | Technomed Medical Systems | Ultrasound therapy apparatus delivering ultrasound waves having thermal and cavitation effects |
| FR2685872A1 (fr) | 1992-01-07 | 1993-07-09 | Edap Int | Appareil d'hyperthermie ultrasonore extracorporelle a tres grande puissance et son procede de fonctionnement. |
| US6436078B1 (en) | 1994-12-06 | 2002-08-20 | Pal Svedman | Transdermal perfusion of fluids |
| DE4207463C2 (de) | 1992-03-10 | 1996-03-28 | Siemens Ag | Anordnung zur Therapie von Gewebe mit Ultraschall |
| WO1993019705A1 (en) | 1992-03-31 | 1993-10-14 | Massachusetts Institute Of Technology | Apparatus and method for acoustic heat generation and hyperthermia |
| US5230340A (en) | 1992-04-13 | 1993-07-27 | General Electric Company | Ultrasound imaging system with improved dynamic focusing |
| US5295484A (en) | 1992-05-19 | 1994-03-22 | Arizona Board Of Regents For And On Behalf Of The University Of Arizona | Apparatus and method for intra-cardiac ablation of arrhythmias |
| US5222806A (en) | 1992-06-04 | 1993-06-29 | C. N. Burman Co. | Lamp |
| US5362309A (en) | 1992-09-14 | 1994-11-08 | Coraje, Inc. | Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis |
| DE69331692T2 (de) | 1992-09-16 | 2002-10-24 | Hitachi Ltd | Ultraschallbestrahlungsgeraet |
| US6315772B1 (en) | 1993-09-24 | 2001-11-13 | Transmedica International, Inc. | Laser assisted pharmaceutical delivery and fluid removal |
| DE4238645C1 (de) | 1992-11-16 | 1994-05-05 | Siemens Ag | Therapeutischer Ultraschall-Applikator für den Urogenitalbereich |
| US5393296A (en) | 1992-12-09 | 1995-02-28 | Siemens Aktiengesellschaft | Method for the medical treatment of pathologic bone |
| US5573497A (en) | 1994-11-30 | 1996-11-12 | Technomed Medical Systems And Institut National | High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes |
| US5381325A (en) | 1993-02-19 | 1995-01-10 | Messana; Joseph | Self-positioning lamp fixture with stabilizing base |
| US5469852A (en) | 1993-03-12 | 1995-11-28 | Kabushiki Kaisha Toshiba | Ultrasound diagnosis apparatus and probe therefor |
| DE4310924C2 (de) | 1993-04-02 | 1995-01-26 | Siemens Ag | Therapieeinrichtung zur Behandlung von pathologischem Gewebe mit Ultraschallwellen und einem Katheder |
| DE4403134A1 (de) | 1993-05-14 | 1995-08-03 | Laser Medizin Zentrum Ggmbh Be | Kombinationsvorrichtung zur thermischen Verödung biologischen Gewebes |
| DE4405504B4 (de) | 1994-02-21 | 2008-10-16 | Siemens Ag | Verfahren und Vorrichtung zum Abbilden eines Objekts mit einem 2-D-Ultraschallarray |
| US5509896A (en) | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
| JPH0884740A (ja) | 1994-09-16 | 1996-04-02 | Toshiba Corp | 治療装置 |
| US5694936A (en) | 1994-09-17 | 1997-12-09 | Kabushiki Kaisha Toshiba | Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation |
| JP3754113B2 (ja) | 1994-09-17 | 2006-03-08 | 株式会社東芝 | 超音波治療装置 |
| US5540909A (en) | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| EP0709673A1 (fr) | 1994-10-25 | 1996-05-01 | Laboratoires D'electronique Philips | Dispositif de contrÔle non destructif d'objets tubulaires creux par ultrasons |
| US5520188A (en) | 1994-11-02 | 1996-05-28 | Focus Surgery Inc. | Annular array transducer |
| JP3609832B2 (ja) | 1995-01-20 | 2005-01-12 | メデラ インコーポレイテッド | 乳房シールド及び関連した搾乳器を支持する装置 |
| DE19507305A1 (de) | 1995-03-02 | 1996-09-05 | Delma Elektro Med App | Operationsleuchte mit Hauptlampe und Ersatzlampe |
| US5678554A (en) | 1996-07-02 | 1997-10-21 | Acuson Corporation | Ultrasound transducer for multiple focusing and method for manufacture thereof |
| US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
| US5873902A (en) | 1995-03-31 | 1999-02-23 | Focus Surgery, Inc. | Ultrasound intensity determining method and apparatus |
| US5617862A (en) | 1995-05-02 | 1997-04-08 | Acuson Corporation | Method and apparatus for beamformer system with variable aperture |
| US5558092A (en) | 1995-06-06 | 1996-09-24 | Imarx Pharmaceutical Corp. | Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| AU2997095A (en) | 1995-06-20 | 1997-01-22 | Wan Sing Ng | Articulated arm for medical procedures |
| US5566675A (en) | 1995-06-30 | 1996-10-22 | Siemens Medical Systems, Inc. | Beamformer for phase aberration correction |
| DE69520670T2 (de) | 1995-07-27 | 2001-09-13 | Agilent Technologies Deutschla | Patientenüberwachungsmodul |
| US5582578A (en) | 1995-08-01 | 1996-12-10 | Duke University | Method for the comminution of concretions |
| JPH0955571A (ja) | 1995-08-11 | 1997-02-25 | Hewlett Packard Japan Ltd | 高絶縁区画付き電子回路基板及び製造方法 |
| US5648098A (en) | 1995-10-17 | 1997-07-15 | The Board Of Regents Of The University Of Nebraska | Thrombolytic agents and methods of treatment for thrombosis |
| US5590657A (en) | 1995-11-06 | 1997-01-07 | The Regents Of The University Of Michigan | Phased array ultrasound system and method for cardiac ablation |
| EP0888086B1 (en) | 1996-02-15 | 2005-07-27 | Biosense Webster, Inc. | Excavation probe |
| US5676692A (en) | 1996-03-28 | 1997-10-14 | Indianapolis Center For Advanced Research, Inc. | Focussed ultrasound tissue treatment method |
| CH691345A5 (de) | 1996-04-18 | 2001-07-13 | Siemens Ag | Therapiegerät mit einfacher Einstellung eines gewünschten Abstandes von einem Bezugspunkt. |
| US20020045890A1 (en) | 1996-04-24 | 2002-04-18 | The Regents Of The University O F California | Opto-acoustic thrombolysis |
| US6022309A (en) | 1996-04-24 | 2000-02-08 | The Regents Of The University Of California | Opto-acoustic thrombolysis |
| US5724972A (en) | 1996-05-02 | 1998-03-10 | Acuson Corporation | Method and apparatus for distributed focus control with slope tracking |
| US5717657A (en) | 1996-06-24 | 1998-02-10 | The United States Of America As Represented By The Secretary Of The Navy | Acoustical cavitation suppressor for flow fields |
| US5849727A (en) | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
| US5836896A (en) | 1996-08-19 | 1998-11-17 | Angiosonics | Method of inhibiting restenosis by applying ultrasonic energy |
| US5753929A (en) | 1996-08-28 | 1998-05-19 | Motorola, Inc. | Multi-directional optocoupler and method of manufacture |
| DE19635593C1 (de) | 1996-09-02 | 1998-04-23 | Siemens Ag | Ultraschallwandler für den diagnostischen und therapeutischen Einsatz |
| CA2213948C (en) | 1996-09-19 | 2006-06-06 | United States Surgical Corporation | Ultrasonic dissector |
| US6036667A (en) | 1996-10-04 | 2000-03-14 | United States Surgical Corporation | Ultrasonic dissection and coagulation system |
| US5769790A (en) | 1996-10-25 | 1998-06-23 | General Electric Company | Focused ultrasound surgery system guided by ultrasound imaging |
| US5827204A (en) | 1996-11-26 | 1998-10-27 | Grandia; Willem | Medical noninvasive operations using focused modulated high power ultrasound |
| US5797848A (en) | 1997-01-31 | 1998-08-25 | Acuson Corporation | Ultrasonic transducer assembly with improved electrical interface |
| JP2007144225A (ja) | 1997-03-03 | 2007-06-14 | Toshiba Corp | 超音波治療装置 |
| WO1998048711A1 (en) | 1997-05-01 | 1998-11-05 | Ekos Corporation | Ultrasound catheter |
| US5879314A (en) | 1997-06-30 | 1999-03-09 | Cybersonics, Inc. | Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi |
| US6093883A (en) | 1997-07-15 | 2000-07-25 | Focus Surgery, Inc. | Ultrasound intensity determining method and apparatus |
| US5944666A (en) | 1997-08-21 | 1999-08-31 | Acuson Corporation | Ultrasonic method for imaging blood flow including disruption or activation of contrast agent |
| US6128958A (en) | 1997-09-11 | 2000-10-10 | The Regents Of The University Of Michigan | Phased array system architecture |
| US6113558A (en) | 1997-09-29 | 2000-09-05 | Angiosonics Inc. | Pulsed mode lysis method |
| WO1999022644A1 (en) | 1997-11-03 | 1999-05-14 | Barzell Whitmore Maroon Bells, Inc. | Ultrasound interface control system |
| DE19800416C2 (de) | 1998-01-08 | 2002-09-19 | Storz Karl Gmbh & Co Kg | Vorrichtung zur Behandlung von Körpergewebe, insbesondere von oberflächennahem Weichgewebe, mittels Ultraschall |
| WO1999034858A1 (en) | 1998-01-12 | 1999-07-15 | Georgia Tech Research Corporation | Assessment and control of acoustic tissue effects |
| US6896659B2 (en) | 1998-02-06 | 2005-05-24 | Point Biomedical Corporation | Method for ultrasound triggered drug delivery using hollow microbubbles with controlled fragility |
| US6511444B2 (en) | 1998-02-17 | 2003-01-28 | Brigham And Women's Hospital | Transmyocardial revascularization using ultrasound |
| US6659105B2 (en) | 1998-02-26 | 2003-12-09 | Senorx, Inc. | Tissue specimen isolating and damaging device and method |
| US6165144A (en) | 1998-03-17 | 2000-12-26 | Exogen, Inc. | Apparatus and method for mounting an ultrasound transducer |
| US6685640B1 (en) | 1998-03-30 | 2004-02-03 | Focus Surgery, Inc. | Ablation system |
| FR2778573B1 (fr) | 1998-05-13 | 2000-09-22 | Technomed Medical Systems | Reglage de frequence dans un appareil de traitement par ultrasons focalises de haute intensite |
| JP4095729B2 (ja) | 1998-10-26 | 2008-06-04 | 株式会社日立製作所 | 治療用超音波装置 |
| DE69937747T2 (de) | 1998-10-28 | 2008-12-04 | Covaris, Inc., Woburn | Vorrichtung und verfahren zur kontrolle einer akustischen behandlung |
| US7687039B2 (en) | 1998-10-28 | 2010-03-30 | Covaris, Inc. | Methods and systems for modulating acoustic energy delivery |
| WO2000030554A1 (en) | 1998-11-20 | 2000-06-02 | Jones Joie P | Methods for selectively dissolving and removing materials using ultra-high frequency ultrasound |
| US6309355B1 (en) | 1998-12-22 | 2001-10-30 | The Regents Of The University Of Michigan | Method and assembly for performing ultrasound surgery using cavitation |
| US6296619B1 (en) | 1998-12-30 | 2001-10-02 | Pharmasonics, Inc. | Therapeutic ultrasonic catheter for delivering a uniform energy dose |
| US6508774B1 (en) | 1999-03-09 | 2003-01-21 | Transurgical, Inc. | Hifu applications with feedback control |
| US6308710B1 (en) | 1999-04-12 | 2001-10-30 | David Silva | Scrotal drape and support |
| JP2000300559A (ja) | 1999-04-26 | 2000-10-31 | Olympus Optical Co Ltd | 超音波探触子及びその製造方法 |
| FR2792996B1 (fr) | 1999-04-28 | 2001-07-13 | Alm | Butee souple de limitation de course angulaire, systeme articule comprenant une telle butee, et equipement medical comportant un tel systeme articule |
| US6890332B2 (en) | 1999-05-24 | 2005-05-10 | Csaba Truckai | Electrical discharge devices and techniques for medical procedures |
| AU768759B2 (en) | 1999-06-14 | 2004-01-08 | Exogen, Inc. | Method and kit for cavitation-induced tissue healing with low intensity ultrasound |
| US6318146B1 (en) | 1999-07-14 | 2001-11-20 | Wisconsin Alumni Research Foundation | Multi-imaging modality tissue mimicking materials for imaging phantoms |
| DE19933135A1 (de) | 1999-07-19 | 2001-01-25 | Thomson Brandt Gmbh | Galvanische Isoliervorrichtung mit Optokoppler für bidirektionale Verbindungsleitungen |
| US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
| EP1202670A4 (en) | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE |
| US6470204B1 (en) | 1999-08-25 | 2002-10-22 | Egidijus Edward Uzgiris | Intracavity probe for MR image guided biopsy and delivery of therapy |
| AU775490B2 (en) | 1999-10-05 | 2004-08-05 | Omnisonics Medical Technologies, Inc. | Method and apparatus for ultrasonic medical treatment, in particular, for debulking the prostate |
| US20030236539A1 (en) | 1999-10-05 | 2003-12-25 | Omnisonics Medical Technologies, Inc. | Apparatus and method for using an ultrasonic probe to clear a vascular access device |
| US6524251B2 (en) | 1999-10-05 | 2003-02-25 | Omnisonics Medical Technologies, Inc. | Ultrasonic device for tissue ablation and sheath for use therewith |
| US20040097996A1 (en) | 1999-10-05 | 2004-05-20 | Omnisonics Medical Technologies, Inc. | Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode |
| US6391020B1 (en) | 1999-10-06 | 2002-05-21 | The Regents Of The Univerity Of Michigan | Photodisruptive laser nucleation and ultrasonically-driven cavitation of tissues and materials |
| JP2003513691A (ja) | 1999-10-25 | 2003-04-15 | シーラス、コーポレイション | 血管を封止するための集束超音波の使用 |
| US7300414B1 (en) | 1999-11-01 | 2007-11-27 | University Of Cincinnati | Transcranial ultrasound thrombolysis system and method of treating a stroke |
| US6626855B1 (en) | 1999-11-26 | 2003-09-30 | Therus Corpoation | Controlled high efficiency lesion formation using high intensity ultrasound |
| JP4306996B2 (ja) | 1999-12-06 | 2009-08-05 | ミロ シムチャ | 超音波医療装置 |
| US6719694B2 (en) | 1999-12-23 | 2004-04-13 | Therus Corporation | Ultrasound transducers for imaging and therapy |
| US6635017B1 (en) | 2000-02-09 | 2003-10-21 | Spentech, Inc. | Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis |
| US6308585B1 (en) | 2000-02-10 | 2001-10-30 | Ultra Sonus Ab | Method and a device for attaching ultrasonic transducers |
| US6750463B1 (en) | 2000-02-29 | 2004-06-15 | Hill-Rom Services, Inc. | Optical isolation apparatus and method |
| JP3565758B2 (ja) | 2000-03-09 | 2004-09-15 | 株式会社日立製作所 | 腫瘍治療用増感剤 |
| AU2001245831A1 (en) | 2000-03-15 | 2001-09-24 | The Regents Of The University Of California | Method and apparatus for dynamic focusing of ultrasound energy |
| US6543272B1 (en) | 2000-04-21 | 2003-04-08 | Insightec-Txsonics Ltd. | Systems and methods for testing and calibrating a focused ultrasound transducer array |
| US6419648B1 (en) | 2000-04-21 | 2002-07-16 | Insightec-Txsonics Ltd. | Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system |
| US6613004B1 (en) | 2000-04-21 | 2003-09-02 | Insightec-Txsonics, Ltd. | Systems and methods for creating longer necrosed volumes using a phased array focused ultrasound system |
| US6536553B1 (en) | 2000-04-25 | 2003-03-25 | The United States Of America As Represented By The Secretary Of The Army | Method and apparatus using acoustic sensor for sub-surface object detection and visualization |
| AU2001263213B2 (en) | 2000-05-16 | 2005-05-19 | Atrionix, Inc. | Apparatus and method incorporating an ultrasound transducer onto a delivery member |
| US6556750B2 (en) | 2000-05-26 | 2003-04-29 | Fairchild Semiconductor Corporation | Bi-directional optical coupler |
| US6477426B1 (en) | 2000-06-20 | 2002-11-05 | Celsion Corporation | System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors |
| US6506171B1 (en) | 2000-07-27 | 2003-01-14 | Insightec-Txsonics, Ltd | System and methods for controlling distribution of acoustic energy around a focal point using a focused ultrasound system |
| AU2001280040A1 (en) | 2000-07-31 | 2002-02-13 | Galil Medical Ltd. | Planning and facilitation systems and methods for cryosurgery |
| IL137689A0 (en) | 2000-08-03 | 2001-10-31 | L R Res & Dev Ltd | System for enhanced chemical debridement |
| AU2001272727A1 (en) | 2000-08-21 | 2002-03-04 | V-Target Technologies Ltd. | Radioactive emission detector |
| US6612988B2 (en) | 2000-08-29 | 2003-09-02 | Brigham And Women's Hospital, Inc. | Ultrasound therapy |
| US7299803B2 (en) | 2000-10-09 | 2007-11-27 | Ams Research Corporation | Pelvic surgery drape |
| US6589174B1 (en) | 2000-10-20 | 2003-07-08 | Sunnybrook & Women's College Health Sciences Centre | Technique and apparatus for ultrasound therapy |
| ATE489909T1 (de) | 2000-10-25 | 2010-12-15 | Exogen Inc | Wandlermontagesystem |
| US6666833B1 (en) | 2000-11-28 | 2003-12-23 | Insightec-Txsonics Ltd | Systems and methods for focussing an acoustic energy beam transmitted through non-uniform tissue medium |
| US6506154B1 (en) | 2000-11-28 | 2003-01-14 | Insightec-Txsonics, Ltd. | Systems and methods for controlling a phased array focused ultrasound system |
| US6613005B1 (en) | 2000-11-28 | 2003-09-02 | Insightec-Txsonics, Ltd. | Systems and methods for steering a focused ultrasound array |
| US6770031B2 (en) | 2000-12-15 | 2004-08-03 | Brigham And Women's Hospital, Inc. | Ultrasound therapy |
| US6645162B2 (en) | 2000-12-27 | 2003-11-11 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
| US6626854B2 (en) | 2000-12-27 | 2003-09-30 | Insightec - Txsonics Ltd. | Systems and methods for ultrasound assisted lipolysis |
| US6607498B2 (en) | 2001-01-03 | 2003-08-19 | Uitra Shape, Inc. | Method and apparatus for non-invasive body contouring by lysing adipose tissue |
| US7347855B2 (en) | 2001-10-29 | 2008-03-25 | Ultrashape Ltd. | Non-invasive ultrasonic body contouring |
| JP4712980B2 (ja) | 2001-01-18 | 2011-06-29 | 株式会社日立メディコ | 超音波装置 |
| US20020099356A1 (en) | 2001-01-19 | 2002-07-25 | Unger Evan C. | Transmembrane transport apparatus and method |
| US6559644B2 (en) | 2001-05-30 | 2003-05-06 | Insightec - Txsonics Ltd. | MRI-based temperature mapping with error compensation |
| US6735461B2 (en) | 2001-06-19 | 2004-05-11 | Insightec-Txsonics Ltd | Focused ultrasound system with MRI synchronization |
| US6820160B1 (en) | 2001-08-21 | 2004-11-16 | Cypress Semiconductor Corporation | Apparatus for optically isolating a USB peripheral from a USB host |
| US7175596B2 (en) | 2001-10-29 | 2007-02-13 | Insightec-Txsonics Ltd | System and method for sensing and locating disturbances in an energy path of a focused ultrasound system |
| US7438685B2 (en) | 2001-11-05 | 2008-10-21 | Computerized Medical Systems, Inc. | Apparatus and method for registration, guidance and targeting of external beam radiation therapy |
| US20040243021A1 (en) | 2001-11-06 | 2004-12-02 | Murphy John C. | Device for thermal stimulation of small neural fibers |
| US6790180B2 (en) | 2001-12-03 | 2004-09-14 | Insightec-Txsonics Ltd. | Apparatus, systems, and methods for measuring power output of an ultrasound transducer |
| US6522142B1 (en) | 2001-12-14 | 2003-02-18 | Insightec-Txsonics Ltd. | MRI-guided temperature mapping of tissue undergoing thermal treatment |
| CN1643784A (zh) | 2002-01-18 | 2005-07-20 | 美国技术公司 | 调制器放大器 |
| SG114521A1 (en) | 2002-01-21 | 2005-09-28 | Univ Nanyang | Ultrasonic treatment of breast cancers |
| US6942617B2 (en) | 2002-02-04 | 2005-09-13 | Shen-Min Liang | Automatic stone-tracking system |
| WO2003070105A1 (en) | 2002-02-20 | 2003-08-28 | Liposonix, Inc. | Ultrasonic treatment and imaging of adipose tissue |
| US6736814B2 (en) | 2002-02-28 | 2004-05-18 | Misonix, Incorporated | Ultrasonic medical treatment device for bipolar RF cauterization and related method |
| US6648839B2 (en) | 2002-02-28 | 2003-11-18 | Misonix, Incorporated | Ultrasonic medical treatment device for RF cauterization and related method |
| US6890083B2 (en) | 2002-03-11 | 2005-05-10 | Dennis Cochran | Underwater probe and illumination device |
| US6780161B2 (en) | 2002-03-22 | 2004-08-24 | Fmd, Llc | Apparatus for extracorporeal shock wave lithotripter using at least two shock wave pulses |
| US20030181890A1 (en) | 2002-03-22 | 2003-09-25 | Schulze Dale R. | Medical device that removably attaches to a bodily organ |
| US7128711B2 (en) | 2002-03-25 | 2006-10-31 | Insightec, Ltd. | Positioning systems and methods for guided ultrasound therapy systems |
| WO2003092793A2 (en) | 2002-04-05 | 2003-11-13 | Misonix Incorporated | Electromechanical transducer with ergonomic shape |
| US20030199857A1 (en) | 2002-04-17 | 2003-10-23 | Dornier Medtech Systems Gmbh | Apparatus and method for manipulating acoustic pulses |
| KR100923717B1 (ko) | 2002-06-25 | 2009-10-27 | 울트라세이프 인코포레이티드 | 신체 미용에 유용한 디바이스 및 방법 |
| DE10228550B3 (de) | 2002-06-26 | 2004-02-12 | Dornier Medtech Systems Gmbh | Lithotripter zur Fragmentierung eines Zielobjekts in einem Körper und Verfahren zur Überwachung der Fragmentierung eines Zielobjekts in einem Körper |
| US20050020945A1 (en) | 2002-07-02 | 2005-01-27 | Tosaya Carol A. | Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy |
| US6705994B2 (en) | 2002-07-08 | 2004-03-16 | Insightec - Image Guided Treatment Ltd | Tissue inhomogeneity correction in ultrasound imaging |
| US6852082B2 (en) | 2002-07-17 | 2005-02-08 | Adam Strickberger | Apparatus and methods for performing non-invasive vasectomies |
| US7367948B2 (en) | 2002-08-29 | 2008-05-06 | The Regents Of The University Of Michigan | Acoustic monitoring method and system in laser-induced optical breakdown (LIOB) |
| JP3780253B2 (ja) | 2002-10-01 | 2006-05-31 | オリンパス株式会社 | 超音波用ファントム |
| US20040067591A1 (en) | 2002-10-04 | 2004-04-08 | Wisconsin Alumni Research Foundation | Tissue mimicking elastography phantoms |
| US7004282B2 (en) | 2002-10-28 | 2006-02-28 | Misonix, Incorporated | Ultrasonic horn |
| US7697972B2 (en) | 2002-11-19 | 2010-04-13 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
| US7374551B2 (en) | 2003-02-19 | 2008-05-20 | Pittsburgh Plastic Surgery Research Associates | Minimally invasive fat cavitation method |
| US20040162507A1 (en) | 2003-02-19 | 2004-08-19 | Assaf Govari | Externally-applied high intensity focused ultrasound (HIFU) for therapeutic treatment |
| JP2006521902A (ja) | 2003-03-31 | 2006-09-28 | ライポソニックス， インコーポレイテッド | 渦型トランスデューサー |
| US7175599B2 (en) * | 2003-04-17 | 2007-02-13 | Brigham And Women's Hospital, Inc. | Shear mode diagnostic ultrasound |
| IL155546A (en) | 2003-04-22 | 2010-06-16 | Healfus Ltd | Apparatus for treatment of damaged tissue |
| US7377900B2 (en) | 2003-06-02 | 2008-05-27 | Insightec - Image Guided Treatment Ltd. | Endo-cavity focused ultrasound transducer |
| US7006864B2 (en) | 2003-06-17 | 2006-02-28 | Ebr Systems, Inc. | Methods and systems for vibrational treatment of cardiac arrhythmias |
| US20050171428A1 (en) | 2003-07-21 | 2005-08-04 | Gabor Fichtinger | Registration of ultrasound to fluoroscopy for real time optimization of radiation implant procedures |
| AU2003262631A1 (en) | 2003-08-14 | 2005-03-10 | Duke University | Apparatus for improved shock-wave lithotripsy (swl) using a piezoelectric annular array (peaa) shock-wave generator in combination with a primary shock wave |
| US20050038361A1 (en) | 2003-08-14 | 2005-02-17 | Duke University | Apparatus for improved shock-wave lithotripsy (SWL) using a piezoelectric annular array (PEAA) shock-wave generator in combination with a primary shock wave source |
| US7358226B2 (en) | 2003-08-27 | 2008-04-15 | The Regents Of The University Of California | Ultrasonic concentration of drug delivery capsules |
| US7359640B2 (en) | 2003-09-30 | 2008-04-15 | Stmicroelectronics Sa | Optical coupling device and method for bidirectional data communication over a common signal line |
| JP2005167058A (ja) | 2003-12-04 | 2005-06-23 | Oval Corp | 防爆用絶縁分離回路 |
| US8337407B2 (en) | 2003-12-30 | 2012-12-25 | Liposonix, Inc. | Articulating arm for medical procedures |
| US20050154308A1 (en) | 2003-12-30 | 2005-07-14 | Liposonix, Inc. | Disposable transducer seal |
| EP1699360A4 (en) | 2003-12-30 | 2009-05-06 | Liposonix Inc | COMPOUND ULTRASONIC TRANSDUCER |
| US7993289B2 (en) | 2003-12-30 | 2011-08-09 | Medicis Technologies Corporation | Systems and methods for the destruction of adipose tissue |
| JP2007516810A (ja) | 2003-12-30 | 2007-06-28 | ライポソニックス， インコーポレイテッド | 動作制御を有する超音波治療ヘッド |
| US7341569B2 (en) | 2004-01-30 | 2008-03-11 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
| WO2005074365A2 (en) | 2004-02-06 | 2005-08-18 | Technion Research And Development Foundation Ltd. | Localized production of microbubbles and control of cavitational and heating effects by use of enhanced ultrasound |
| WO2005092197A1 (en) | 2004-03-09 | 2005-10-06 | Robarts Research Institute | An apparatus and computing device for performing brachytherapy and methods of imaging using the same |
| US7196313B2 (en) | 2004-04-02 | 2007-03-27 | Fairchild Semiconductor Corporation | Surface mount multi-channel optocoupler |
| US20050234438A1 (en) | 2004-04-15 | 2005-10-20 | Mast T D | Ultrasound medical treatment system and method |
| WO2005107601A2 (en) | 2004-05-06 | 2005-11-17 | Focus Surgery, Inc. | Method and apparatus for the selective treatment of tissue |
| WO2005107622A1 (en) | 2004-05-06 | 2005-11-17 | Nanyang Technological University | Mechanical manipulator for hifu transducers |
| EP1761173A4 (en) | 2004-05-10 | 2009-12-16 | Venousonics Ltd | REINFORCEMENT OF ULTRASOUND CAVITATION |
| FI116176B (fi) | 2004-05-18 | 2005-09-30 | Abb Oy | Maadoitus- ja ylijännitesuojausjärjestely |
| JP2008509777A (ja) | 2004-08-17 | 2008-04-03 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 超音波を用いた画像誘導による組織損傷の処置 |
| US20060060991A1 (en) | 2004-09-21 | 2006-03-23 | Interuniversitair Microelektronica Centrum (Imec) | Method and apparatus for controlled transient cavitation |
| US20060074303A1 (en) | 2004-09-28 | 2006-04-06 | Minnesota Medical Physics Llc | Apparatus and method for conformal radiation brachytherapy for prostate gland and other tumors |
| US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
| EP1804668B1 (en) | 2004-10-18 | 2012-05-23 | Mobile Robotics Sweden AB | Robot for ultrasonic examination |
| US20060264760A1 (en) | 2005-02-10 | 2006-11-23 | Board Of Regents, The University Of Texas System | Near infrared transrectal probes for prostate cancer detection and prognosis |
| US20060206028A1 (en) | 2005-03-11 | 2006-09-14 | Qi Yu | Apparatus and method for ablating deposits from blood vessel |
| FR2883190B1 (fr) | 2005-03-15 | 2007-08-10 | Edap S A | Sonde therapeuthique endo-cavitaire comportant un transducteur d'imagerie integre au sein du transducteur ultrasonore de therapie |
| US20060241523A1 (en) | 2005-04-12 | 2006-10-26 | Prorhythm, Inc. | Ultrasound generating method, apparatus and probe |
| CN1669672A (zh) | 2005-04-20 | 2005-09-21 | 南京航空航天大学 | 压电式多阵元高强度聚焦超声换能器及聚焦方法 |
| EP1904179A2 (en) | 2005-06-07 | 2008-04-02 | Koninklijke Philips Electronics N.V. | Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids |
| US20070016039A1 (en) | 2005-06-21 | 2007-01-18 | Insightec-Image Guided Treatment Ltd. | Controlled, non-linear focused ultrasound treatment |
| US20060293630A1 (en) | 2005-06-22 | 2006-12-28 | Misonix Incorporated | Fluid containment apparatus for surgery and method of use |
| US20110319927A1 (en) | 2005-06-24 | 2011-12-29 | Penumbra, Inc. | Methods and apparatus for removing blood clots from intracranial aneurysms |
| US20070010805A1 (en) | 2005-07-08 | 2007-01-11 | Fedewa Russell J | Method and apparatus for the treatment of tissue |
| US20070065420A1 (en) | 2005-08-23 | 2007-03-22 | Johnson Lanny L | Ultrasound Therapy Resulting in Bone Marrow Rejuvenation |
| US7430913B2 (en) | 2005-08-26 | 2008-10-07 | The Boeing Company | Rapid prototype integrated matrix ultrasonic transducer array inspection apparatus, systems, and methods |
| US7967763B2 (en) | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
| US8414494B2 (en) | 2005-09-16 | 2013-04-09 | University Of Washington | Thin-profile therapeutic ultrasound applicators |
| US20070083120A1 (en) | 2005-09-22 | 2007-04-12 | Cain Charles A | Pulsed cavitational ultrasound therapy |
| US8057408B2 (en) | 2005-09-22 | 2011-11-15 | The Regents Of The University Of Michigan | Pulsed cavitational ultrasound therapy |
| US10219815B2 (en) | 2005-09-22 | 2019-03-05 | The Regents Of The University Of Michigan | Histotripsy for thrombolysis |
| US8342467B2 (en) | 2005-10-04 | 2013-01-01 | Eric Ronald Stachowski | Apparatus for hand control, pressure amplification, and stabilization of medical and industrial devices |
| CA2628824A1 (en) | 2005-11-07 | 2007-05-18 | Smith & Nephew, Inc. | Apparatus for mounting an ultrasonic therapeutic device to an orthopaedic cast |
| US9387515B2 (en) | 2005-11-15 | 2016-07-12 | The Brigham And Women's Hospital, Inc. | Impedance matching for ultrasound phased array elements |
| DE602006019308D1 (de) | 2005-11-30 | 2011-02-10 | Urotech Pty Ltd | Urologisches tuch |
| US20090030339A1 (en) | 2006-01-26 | 2009-01-29 | Cheng Wai Sam C | Apparatus and method for motorised placement of needle |
| EP3045273B1 (en) | 2006-03-03 | 2018-12-12 | Universal Robots A/S | Joint for a robot |
| US8235901B2 (en) | 2006-04-26 | 2012-08-07 | Insightec, Ltd. | Focused ultrasound system with far field tail suppression |
| US20080154181A1 (en) | 2006-05-05 | 2008-06-26 | Khanna Rohit K | Central nervous system ultrasonic drain |
| US7431704B2 (en) | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
| JP4800862B2 (ja) | 2006-06-21 | 2011-10-26 | 株式会社日立製作所 | ファントム |
| US20080033297A1 (en) | 2006-08-02 | 2008-02-07 | Sliwa John W | Neural tissue stimulation, assessment, mapping, and therapy utilizing targeted acoustic mechanisms |
| US20080033417A1 (en) | 2006-08-04 | 2008-02-07 | Nields Morgan W | Apparatus for planning and performing thermal ablation |
| US7449947B2 (en) | 2006-09-06 | 2008-11-11 | Texas Instruments Incorporated | Reduction of voltage spikes in switching half-bridge stages |
| US8332567B2 (en) | 2006-09-19 | 2012-12-11 | Fisher-Rosemount Systems, Inc. | Apparatus and methods to communicatively couple field devices to controllers in a process control system |
| US7559905B2 (en) | 2006-09-21 | 2009-07-14 | Focus Surgery, Inc. | HIFU probe for treating tissue with in-line degassing of fluid |
| US8535250B2 (en) | 2006-10-13 | 2013-09-17 | University Of Washington Through Its Center For Commercialization | Method and apparatus to detect the fragmentation of kidney stones by measuring acoustic scatter |
| US7950980B2 (en) | 2006-10-19 | 2011-05-31 | Medela Holding Ag | System and device for supporting a breast shield |
| US20100056924A1 (en) | 2006-11-20 | 2010-03-04 | Koninklijke Philips Electronics N.V. | Control and display of ultrasonic microbubble cavitation |
| US7714481B2 (en) | 2006-11-30 | 2010-05-11 | Olympus Medical Systems Corp. | Ultrasonic treatment apparatus |
| US8382689B2 (en) | 2007-02-08 | 2013-02-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device and method for high intensity focused ultrasound ablation with acoustic lens |
| PL2170181T3 (pl) * | 2007-06-22 | 2014-08-29 | Ekos Corp | Sposób i aparat do leczenia wylewów wewnątrzczaszkowych |
| US8052604B2 (en) | 2007-07-31 | 2011-11-08 | Mirabilis Medica Inc. | Methods and apparatus for engagement and coupling of an intracavitory imaging and high intensity focused ultrasound probe |
| US8568339B2 (en) | 2007-08-16 | 2013-10-29 | Ultrashape Ltd. | Single element ultrasound transducer with multiple driving circuits |
| US9289137B2 (en) | 2007-09-28 | 2016-03-22 | Volcano Corporation | Intravascular pressure devices incorporating sensors manufactured using deep reactive ion etching |
| US20090227874A1 (en) | 2007-11-09 | 2009-09-10 | Eigen, Inc. | Holder assembly for a medical imaging instrument |
| US20100092424A1 (en) | 2007-11-21 | 2010-04-15 | Sanghvi Narendra T | Method of diagnosis and treatment of tumors using high intensity focused ultrasound |
| US8466605B2 (en) | 2008-03-13 | 2013-06-18 | Ultrashape Ltd. | Patterned ultrasonic transducers |
| US20090287083A1 (en) | 2008-05-14 | 2009-11-19 | Leonid Kushculey | Cavitation detector |
| JP2010029650A (ja) | 2008-07-01 | 2010-02-12 | Yoshihiro Kagamiyama | 医学用超音波ファントム |
| JP2010019554A (ja) | 2008-07-08 | 2010-01-28 | Hioki Ee Corp | 回路基板および測定装置 |
| WO2010030819A1 (en) | 2008-09-10 | 2010-03-18 | The Trustees Of Columbia University In The City Of New York | Systems and methods for opening a tissue |
| JP4421663B1 (ja) | 2008-09-10 | 2010-02-24 | 株式会社東芝 | プリント配線板、電子機器 |
| US9050449B2 (en) | 2008-10-03 | 2015-06-09 | Mirabilis Medica, Inc. | System for treating a volume of tissue with high intensity focused ultrasound |
| US20100125225A1 (en) | 2008-11-19 | 2010-05-20 | Daniel Gelbart | System for selective ultrasonic ablation |
| DE102008059331B4 (de) | 2008-11-27 | 2012-05-31 | Siemens Aktiengesellschaft | Stativ, insbesondere Bodenstativ |
| WO2010096495A1 (en) * | 2009-02-18 | 2010-08-26 | The Regents Of The University Of California | Device, methods, and control for sonic guidance of molecules and other material utilizing time-reversal acoustics |
| JP5341569B2 (ja) | 2009-03-06 | 2013-11-13 | 日置電機株式会社 | 絶縁入力型計測機器 |
| WO2010108104A1 (en) | 2009-03-20 | 2010-09-23 | University Of Cincinnati | Ultrasound-mediated inducement, detection, and enhancement of stable cavitation |
| WO2010118387A1 (en) | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| EP2243561B1 (en) | 2009-04-23 | 2018-11-28 | Esaote S.p.A. | Array of electroacoustic transducers and electronic probe for three-dimensional images comprising said transducer array |
| US20100298744A1 (en) | 2009-04-30 | 2010-11-25 | Palomar Medical Technologies, Inc. | System and method of treating tissue with ultrasound energy |
| US8992426B2 (en) | 2009-05-04 | 2015-03-31 | Siemens Medical Solutions Usa, Inc. | Feedback in medical ultrasound imaging for high intensity focused ultrasound |
| US20100286519A1 (en) | 2009-05-11 | 2010-11-11 | General Electric Company | Ultrasound system and method to automatically identify and treat adipose tissue |
| CN102421372B (zh) | 2009-05-13 | 2014-10-29 | 皇家飞利浦电子股份有限公司 | 具有音高偏移的超声血流多普勒音频 |
| US9028434B2 (en) | 2009-05-18 | 2015-05-12 | Olympus Medical Systems Corp. | Ultrasound operation apparatus, cavitation control method, and ultrasound transducer control method |
| US8449466B2 (en) | 2009-05-28 | 2013-05-28 | Edwards Lifesciences Corporation | System and method for locating medical devices in vivo using ultrasound Doppler mode |
| US8845537B2 (en) | 2009-06-03 | 2014-09-30 | Olympus Medical Systems Corp. | Ultrasound operation apparatus, ultrasound operation system, and cavitation utilization method |
| WO2010143072A1 (en) | 2009-06-10 | 2010-12-16 | Insightec Ltd. | Acoustic-feedback power control during focused ultrasound delivery |
| US11562665B2 (en) | 2009-06-29 | 2023-01-24 | Koninklijke Philips N.V. | Tumor ablation training system |
| WO2011004449A1 (ja) | 2009-07-06 | 2011-01-13 | オリンパスメディカルシステムズ株式会社 | 超音波手術装置 |
| JP5702780B2 (ja) | 2009-07-21 | 2015-04-15 | ユニバーシティ オブ バージニア パテント ファウンデーション | カテーテルシステム |
| US9061131B2 (en) | 2009-08-17 | 2015-06-23 | Histosonics, Inc. | Disposable acoustic coupling medium container |
| CA2770706C (en) | 2009-08-26 | 2017-06-20 | Charles A. Cain | Devices and methods for using controlled bubble cloud cavitation in fractionating urinary stones |
| US9943708B2 (en) | 2009-08-26 | 2018-04-17 | Histosonics, Inc. | Automated control of micromanipulator arm for histotripsy prostate therapy while imaging via ultrasound transducers in real time |
| US8539813B2 (en) | 2009-09-22 | 2013-09-24 | The Regents Of The University Of Michigan | Gel phantoms for testing cavitational ultrasound (histotripsy) transducers |
| GB0916634D0 (en) | 2009-09-22 | 2009-11-04 | Isis Innovation | Ultrasound systems |
| JP5542399B2 (ja) | 2009-09-30 | 2014-07-09 | 株式会社日立製作所 | 絶縁回路基板およびそれを用いたパワー半導体装置、又はインバータモジュール |
| US20140074076A1 (en) | 2009-10-12 | 2014-03-13 | Kona Medical, Inc. | Non-invasive autonomic nervous system modulation |
| US8295912B2 (en) | 2009-10-12 | 2012-10-23 | Kona Medical, Inc. | Method and system to inhibit a function of a nerve traveling with an artery |
| US20110118600A1 (en) | 2009-11-16 | 2011-05-19 | Michael Gertner | External Autonomic Modulation |
| US9174065B2 (en) | 2009-10-12 | 2015-11-03 | Kona Medical, Inc. | Energetic modulation of nerves |
| US8376970B2 (en) | 2009-10-29 | 2013-02-19 | Eilaz Babaev | Ultrasound apparatus and methods for mitigation of neurological damage |
| US20110112400A1 (en) | 2009-11-06 | 2011-05-12 | Ardian, Inc. | High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation |
| US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
| JP4734448B2 (ja) | 2009-12-04 | 2011-07-27 | 株式会社日立製作所 | 超音波治療装置 |
| US20110144490A1 (en) | 2009-12-10 | 2011-06-16 | General Electric Company | Devices and methods for adipose tissue reduction and skin contour irregularity smoothing |
| US20110144545A1 (en) | 2009-12-15 | 2011-06-16 | General Electric Company | Methods And System For Delivering Treatment To A Region Of Interest Using Ultrasound |
| WO2011092683A1 (en) | 2010-02-01 | 2011-08-04 | Livesonics Ltd. | Non-invasive ultrasound treatment of subcostal lesions |
| JP2011212253A (ja) * | 2010-03-31 | 2011-10-27 | Fujifilm Corp | 超音波撮像方法および超音波撮像装置 |
| WO2011125991A1 (ja) | 2010-04-09 | 2011-10-13 | 株式会社日立製作所 | 超音波診断治療装置 |
| US8876740B2 (en) | 2010-04-12 | 2014-11-04 | University Of Washington | Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound therapy |
| WO2011133922A2 (en) | 2010-04-22 | 2011-10-27 | The University Of Washington Through Its Center For Commercialization | Ultrasound based method and apparatus for stone detection and to facilitate clearance thereof |
| US8932237B2 (en) * | 2010-04-28 | 2015-01-13 | Insightec, Ltd. | Efficient ultrasound focusing |
| WO2011138722A1 (en) | 2010-05-03 | 2011-11-10 | Andrey Rybyanets | Resonantly amplified shear waves |
| FR2960789B1 (fr) | 2010-06-07 | 2013-07-19 | Image Guided Therapy | Transducteur d'ultrasons a usage medical |
| US10231712B2 (en) | 2010-06-09 | 2019-03-19 | Regents Of The University Of Minnesota | Dual mode ultrasound transducer (DMUT) system and method for controlling delivery of ultrasound therapy |
| EP2397188A1 (en) | 2010-06-15 | 2011-12-21 | Theraclion SAS | Ultrasound probe head comprising an imaging transducer with a shielding element |
| US20120029393A1 (en) | 2010-07-30 | 2012-02-02 | General Electric Company | Compact ultrasound transducer assembly and methods of making and using the same |
| US9149658B2 (en) | 2010-08-02 | 2015-10-06 | Guided Therapy Systems, Llc | Systems and methods for ultrasound treatment |
| US20120092724A1 (en) | 2010-08-18 | 2012-04-19 | Pettis Nathaniel B | Networked three-dimensional printing |
| US8333115B1 (en) | 2010-08-26 | 2012-12-18 | The Boeing Company | Inspection apparatus and method for irregular shaped, closed cavity structures |
| EP2608730B1 (en) * | 2010-08-27 | 2019-07-24 | Ekos Corporation | Apparatus for treatment of intracranial hemorrhages |
| US8857438B2 (en) * | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
| US9186220B2 (en) | 2010-12-17 | 2015-11-17 | Ethicon Endo-Surgery, Inc. | Surgical system and methods for mimicked motion |
| US8715187B2 (en) | 2010-12-17 | 2014-05-06 | General Electric Company | Systems and methods for automatically identifying and segmenting different tissue types in ultrasound images |
| US11040140B2 (en) | 2010-12-31 | 2021-06-22 | Philips Image Guided Therapy Corporation | Deep vein thrombosis therapeutic methods |
| US8317703B2 (en) | 2011-02-17 | 2012-11-27 | Vivant Medical, Inc. | Energy-delivery device including ultrasound transducer array and phased antenna array, and methods of adjusting an ablation field radiating into tissue using same |
| US9669203B2 (en) | 2011-03-01 | 2017-06-06 | University Of Cincinnati | Methods of enhancing delivery of drugs using ultrasonic waves and systems for performing the same |
| US8900145B2 (en) | 2011-03-10 | 2014-12-02 | University Of Washington Through Its Center For Commercialization | Ultrasound systems and methods for real-time noninvasive spatial temperature estimation |
| US9498651B2 (en) | 2011-04-11 | 2016-11-22 | University Of Washington | Methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities and associated systems and devices |
| WO2013000091A1 (en) | 2011-06-29 | 2013-01-03 | Sunnybrook Health Sciences Centre | System and method for controlling focused ultrasound treatment |
| WO2013012641A1 (en) | 2011-07-11 | 2013-01-24 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
| US9144694B2 (en) | 2011-08-10 | 2015-09-29 | The Regents Of The University Of Michigan | Lesion generation through bone using histotripsy therapy without aberration correction |
| US9339348B2 (en) | 2011-08-20 | 2016-05-17 | Imperial Colege of Science, Technology and Medicine | Devices, systems, and methods for assessing a vessel |
| US10888232B2 (en) | 2011-08-20 | 2021-01-12 | Philips Image Guided Therapy Corporation | Devices, systems, and methods for assessing a vessel |
| US10874353B2 (en) | 2011-08-31 | 2020-12-29 | Insightec, Ltd. | Systems and methods for avoiding MRI-originated interference with concurrently used systems |
| WO2013030806A1 (en) * | 2011-09-01 | 2013-03-07 | Perseus-Biomed Inc. | Method and system for tissue modulation |
| JP6124897B2 (ja) | 2011-09-20 | 2017-05-10 | サニーブルック リサーチ インスティチュート | 超音波トランスデューサ及びその製造方法 |
| US20130090579A1 (en) | 2011-10-10 | 2013-04-11 | Charles A. Cain | Pulsed Cavitational Therapeutic Ultrasound With Dithering |
| US20130102932A1 (en) | 2011-10-10 | 2013-04-25 | Charles A. Cain | Imaging Feedback of Histotripsy Treatments with Ultrasound Transient Elastography |
| CA2856426A1 (en) | 2011-12-08 | 2013-06-13 | Volcano Corporation | Devices, systems, and methods for visualizing an occluded vessel |
| JP6068503B2 (ja) | 2012-01-06 | 2017-01-25 | ヒストソニックス，インコーポレーテッド | ヒストトリプシ治療用変換器 |
| US10426501B2 (en) | 2012-01-13 | 2019-10-01 | Crux Biomedical, Inc. | Retrieval snare device and method |
| US9084539B2 (en) | 2012-02-02 | 2015-07-21 | Volcano Corporation | Wireless pressure wire system with integrated power |
| KR101481796B1 (ko) | 2012-03-02 | 2015-01-14 | 포항공과대학교 산학협력단 | 3차원 가상 간 수술 계획 시스템 |
| US9049783B2 (en) | 2012-04-13 | 2015-06-02 | Histosonics, Inc. | Systems and methods for obtaining large creepage isolation on printed circuit boards |
| EP2844343B1 (en) | 2012-04-30 | 2018-11-21 | The Regents Of The University Of Michigan | Ultrasound transducer manufacturing using rapid-prototyping method |
| US10869648B2 (en) | 2012-05-11 | 2020-12-22 | Philips Image Guided Therapy Corporation | Device, system and method for flow imaging in the body using a swept transducer |
| CN104363959A (zh) | 2012-05-11 | 2015-02-18 | 加利福尼亚大学董事会 | 在现场启动并监视中风患者治疗的便携式设备 |
| WO2013177430A1 (en) | 2012-05-23 | 2013-11-28 | Sunnybrook Health Sciences Centre | Multi-frequency ultrasound device and method of operation |
| FR2991807B1 (fr) | 2012-06-06 | 2014-08-29 | Centre Nat Rech Scient | Dispositif et procede de focalisation d'impulsions |
| US9808653B2 (en) * | 2012-06-13 | 2017-11-07 | David W. Newell | Treatment of subarachnoid hematoma using sonothrombolysis and associated devices, systems and methods |
| EP2866874B1 (en) | 2012-06-28 | 2019-01-02 | Volcano Corporation | Side-loading connectors for use with intravascular devices and associated systems and methods |
| WO2014008594A1 (en) | 2012-07-08 | 2014-01-16 | Sunnybrook Health Sciences Centre | System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells |
| EP2879573A4 (en) | 2012-08-03 | 2016-08-03 | Volcano Corp | DEVICES, SYSTEMS AND METHODS FOR EVALUATING A VESSEL |
| EP2887989B1 (en) | 2012-08-23 | 2021-02-24 | Philips Image Guided Therapy Corporation | Device for anatomical lesion length estimation |
| JP6509117B2 (ja) | 2012-08-31 | 2019-05-08 | ボルケーノ コーポレイション | 血管内装置のコンポーネントの取り付け構造 |
| US20140073995A1 (en) | 2012-09-11 | 2014-03-13 | Dejan Teofilovic | Histotripsy therapy system |
| KR20140039418A (ko) | 2012-09-21 | 2014-04-02 | 삼성전자주식회사 | 의료용 로봇 시스템 |
| US20140100459A1 (en) | 2012-10-05 | 2014-04-10 | The Regents Of The University Of Michigan | Bubble-induced color doppler feedback during histotripsy |
| EP2914166B1 (en) | 2012-10-31 | 2022-05-25 | Philips Image Guided Therapy Corporation | Dependency-based startup in a multi-modality medical system |
| US20140128734A1 (en) | 2012-11-05 | 2014-05-08 | Ekos Corporation | Catheter systems and methods |
| WO2014071386A1 (en) * | 2012-11-05 | 2014-05-08 | Regents Of The University Of Minnesota | Non-invasive lung pacing |
| WO2014074806A1 (en) | 2012-11-08 | 2014-05-15 | Smith & Nephew, Inc-- | Improved reattachment of detached cartilage to subchondral bone |
| US10631780B2 (en) | 2012-12-05 | 2020-04-28 | Philips Image Guided Therapy Corporation | System and method for non-invasive tissue characterization |
| WO2014099501A1 (en) | 2012-12-20 | 2014-06-26 | Volcano Corporation | Resource management in a multi-modality medical system |
| US10939826B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Aspirating and removing biological material |
| US10942022B2 (en) | 2012-12-20 | 2021-03-09 | Philips Image Guided Therapy Corporation | Manual calibration of imaging system |
| JP6785554B2 (ja) | 2012-12-20 | 2020-11-18 | ボルケーノ コーポレイション | 平滑遷移カテーテル |
| CA2895777A1 (en) | 2012-12-21 | 2014-06-26 | Volcano Corporation | Wireless interface devices, systems, and methods for use with intravascular pressure monitoring devices |
| EP2934653B1 (en) | 2012-12-21 | 2018-09-19 | Douglas Meyer | Rotational ultrasound imaging catheter with extended catheter body telescope |
| JP6479678B2 (ja) | 2012-12-21 | 2019-03-06 | ボルケーノ コーポレイション | マルチセンサ医療デバイスのための表示制御 |
| US10799209B2 (en) | 2012-12-26 | 2020-10-13 | Philips Image Guided Therapy Corporation | Measurement navigation in a multi-modality medical imaging system |
| US9924903B2 (en) | 2012-12-27 | 2018-03-27 | Volcano Corporation | Pressure-sensing guide wire with sliding pressure sensor |
| US9624095B2 (en) | 2012-12-28 | 2017-04-18 | Volcano Corporation | Capacitive intravascular pressure-sensing devices and associated systems and methods |
| US20140187978A1 (en) | 2012-12-28 | 2014-07-03 | Volcano Corporation | Intravascular Devices Having Information Stored Thereon And/Or Wireless Communication Functionality, Including Associated Devices, Systems, And Methods |
| EP2938252B1 (en) | 2012-12-31 | 2019-05-15 | Volcano Corporation | Intravascular device and production method thereof |
| US20140187984A1 (en) | 2012-12-31 | 2014-07-03 | Volcano Corporation | In-Wall Hypotube Sensor Mount for Sensored Guidewire |
| EP2943127A4 (en) | 2013-01-08 | 2016-09-14 | Volcano Corp | PROCESS FOR FOCUSED ACOUSTIC COMPUTER TOMOGRAPHY (FACT) |
| US11376074B2 (en) | 2013-01-25 | 2022-07-05 | Yoav Levy | Simulation-based focused-ultrasound treatment planning |
| US10751125B2 (en) | 2013-01-29 | 2020-08-25 | Insightec, Ltd. | Simulation-based focused-ultrasound treatment planning |
| EP2964328B1 (en) * | 2013-03-06 | 2021-09-01 | Insightec, Ltd. | Frequency optimization in ultrasound treatment |
| US10638939B2 (en) | 2013-03-12 | 2020-05-05 | Philips Image Guided Therapy Corporation | Systems and methods for diagnosing coronary microvascular disease |
| US9228730B1 (en) | 2013-03-12 | 2016-01-05 | The United States Of America As Represented By The Secretary Of The Air Force | Variable radius multi-lamp illumination system |
| US10758207B2 (en) | 2013-03-13 | 2020-09-01 | Philips Image Guided Therapy Corporation | Systems and methods for producing an image from a rotational intravascular ultrasound device |
| US11026591B2 (en) | 2013-03-13 | 2021-06-08 | Philips Image Guided Therapy Corporation | Intravascular pressure sensor calibration |
| US10925688B2 (en) | 2013-03-14 | 2021-02-23 | Philips Image Guided Therapy Corporation | Auxiliary small vasculature guidewire |
| US9592027B2 (en) | 2013-03-14 | 2017-03-14 | Volcano Corporation | System and method of adventitial tissue characterization |
| EP2967370B1 (en) | 2013-03-15 | 2021-09-29 | Philips Image Guided Therapy Corporation | Interface devices, systems, and methods for use with intravascular pressure monitoring devices |
| JP2016517333A (ja) * | 2013-03-15 | 2016-06-16 | ボルケーノ コーポレイション | 圧力及び超音波機能を持つ遠位保護システム及び方法 |
| EP2967369B1 (en) | 2013-03-15 | 2021-05-12 | Philips Image Guided Therapy Corporation | Pressure wire detection and communication protocol for use with medical measurement systems |
| JP6440682B2 (ja) | 2013-03-28 | 2018-12-19 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | 集束超音波機器および使用方法 |
| US20140330124A1 (en) | 2013-05-03 | 2014-11-06 | SonaCare Medical, LLC | Flexible endoscopic probe system and method of using same |
| CN105407969B (zh) | 2013-06-28 | 2019-04-05 | 皇家飞利浦有限公司 | 用于图像引导超声溶栓的换能器放置和配准 |
| US11432900B2 (en) | 2013-07-03 | 2022-09-06 | Histosonics, Inc. | Articulating arm limiter for cavitational ultrasound therapy system |
| CA2917095C (en) * | 2013-07-03 | 2021-11-02 | Bracco Suisse S.A. | Devices and methods for the ultrasound treatment of ischemic stroke |
| BR112015032926B1 (pt) | 2013-07-03 | 2022-04-05 | Histosonics, Inc. | Sistema de terapia de ultrassom |
| US10780298B2 (en) | 2013-08-22 | 2020-09-22 | The Regents Of The University Of Michigan | Histotripsy using very short monopolar ultrasound pulses |
| WO2015031532A1 (en) * | 2013-08-27 | 2015-03-05 | University Of Washington Through Its Center For Commercialization | Systems and methods for treating abscesses and infected fluid collections |
| EP3057495B1 (en) | 2013-10-18 | 2020-07-15 | Volcano Corporation | System for assessing a stenosis in a blood vessel with optimized proximal and distal pressure measurements |
| US10993628B2 (en) | 2013-10-25 | 2021-05-04 | Philips Image Guided Therapy Corporation | Devices, systems, and methods for vessel assessment |
| EP3068308A4 (en) | 2013-11-13 | 2016-11-16 | Volcano Corp | VISUALLY OPTIMIZED INTRAVASCULAR IMAGING AND DEVICES, SYSTEMS, AND RELATED METHODS |
| US9763688B2 (en) | 2013-11-20 | 2017-09-19 | Ethicon Llc | Ultrasonic surgical instrument with features for forming bubbles to enhance cavitation |
| US11006840B2 (en) | 2013-12-06 | 2021-05-18 | Philips Image Guided Therapy Corporation | Device, system, and method for assessing intravascular pressure |
| CN105813553B (zh) | 2013-12-06 | 2021-03-26 | 火山公司 | 用于评估血管内压力的装置、系统和方法 |
| US10874409B2 (en) | 2014-01-14 | 2020-12-29 | Philips Image Guided Therapy Corporation | Methods and systems for clearing thrombus from a vascular access site |
| JP6592849B2 (ja) | 2014-01-21 | 2019-10-23 | プロメディカ バイオエレクトロニクス エス．アール．エル． | 超音波試験のための装置 |
| GB2515134B (en) | 2014-01-27 | 2017-05-17 | King Fahad Medical City (Kfmc) | Therapeutic ultrasound apparatus and method |
| EP3110341A1 (en) | 2014-02-26 | 2017-01-04 | Koninklijke Philips N.V. | System for performing extraluminal coronary bypass and method of operation thereof |
| WO2015128751A1 (en) | 2014-02-26 | 2015-09-03 | Koninklijke Philips N.V. | System for performing intraluminal histotripsy and method of operation thereof. |
| WO2015138781A1 (en) | 2014-03-12 | 2015-09-17 | The Regents Of The University Of Michigan | Frequency compounding ultrasound pulses for imaging and therapy |
| US10694974B2 (en) | 2014-03-27 | 2020-06-30 | University Of Washington | Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound |
| US20170072227A1 (en) | 2014-03-28 | 2017-03-16 | Koninklijke Philips N.V., A Corporporation Organized And Existing Under The Laws | Boiling histotripsy methods and systems for uniform volumetric ablation of an object by high-intensity focused ultrasound waves with shocks |
| WO2015153441A1 (en) | 2014-03-31 | 2015-10-08 | University Of Washington | Methods and systems for selectively disrupting tissue with high intensity focused ultrasound |
| US20170071515A1 (en) | 2014-04-02 | 2017-03-16 | John R. Chevillet | High intensity focused ultrasound and methods of performing non-invasive biopsies using same |
| WO2015161297A1 (en) | 2014-04-17 | 2015-10-22 | The Johns Hopkins University | Robot assisted ultrasound system |
| US10849511B2 (en) | 2014-07-14 | 2020-12-01 | Philips Image Guided Therapy Corporation | Devices, systems, and methods for assessment of vessels |
| JP6606171B2 (ja) | 2014-08-28 | 2019-11-13 | コーニンクレッカ フィリップス エヌ ヴェ | 補強高速交換ポートを有する血管内装置及び関連システム |
| US10843012B2 (en) | 2014-10-22 | 2020-11-24 | Otsuka Medical Devices Co., Ltd. | Optimized therapeutic energy delivery |
| EP3218629B1 (en) | 2014-11-13 | 2020-06-17 | National Oilwell Varco Denmark I/S | A method of installing an unbonded flexible pipe |
| EP3229688B1 (en) | 2014-12-08 | 2020-10-28 | Koninklijke Philips N.V. | Device and method to recommend diagnostic procedure based on co-registered angiographic image and physiological information measured by intravascular device |
| CN106999054B (zh) | 2014-12-08 | 2021-05-28 | 皇家飞利浦有限公司 | 用于经皮冠状动脉介入计划的床旁界面 |
| EP3229696B1 (en) | 2014-12-08 | 2020-01-08 | Koninklijke Philips N.V. | Patient education for percutaneous coronary intervention treatments |
| EP3229721B1 (en) | 2014-12-08 | 2021-09-22 | Koninklijke Philips N.V. | Interactive cardiac test data systems |
| EP3229695B1 (en) | 2014-12-10 | 2023-07-19 | Koninklijke Philips N.V. | Systems for in-stent restenosis prediction |
| US20160206341A1 (en) | 2015-01-20 | 2016-07-21 | Guided Therapy Systems, Llc | Methods and Systems for Removal of a Targeted Tissue from the Body |
| CN107530049B (zh) | 2015-02-20 | 2021-06-04 | 皇家飞利浦有限公司 | 支持成像的斑块切除设备 |
| JP6727286B2 (ja) | 2015-04-02 | 2020-07-22 | カーディアウェイブ | 心膜疾患を治療する方法及び装置 |
| CA2982603A1 (en) | 2015-04-15 | 2016-10-20 | Prospect CharterCare RWMC, LLC d/b/a Roger Williams Medical Center | Hepatic arterial infusion of car-t cells |
| WO2016170446A1 (en) | 2015-04-20 | 2016-10-27 | Koninklijke Philips N.V. | Dual lumen diagnostic catheter |
| WO2017020126A1 (en) | 2015-07-31 | 2017-02-09 | Endra, Inc. | A method and system for correcting fat-induced aberrations |
| ES2753608T3 (es) | 2015-09-29 | 2020-04-13 | Inst Nat Sante Rech Med | Dispositivo y sistema para generar ondas ultrasónicas en una región objetivo de un sólido blando y procedimiento para tratar localmente un tejido |
| US10702719B2 (en) | 2015-10-09 | 2020-07-07 | University Of Washington | Histotripsy treatment of hematoma |
| US9934570B2 (en) | 2015-10-09 | 2018-04-03 | Insightec, Ltd. | Systems and methods for registering images obtained using various imaging modalities and verifying image registration |
| JP6896719B2 (ja) | 2015-10-15 | 2021-06-30 | インサイテック リミテッド | 並行に使用されるｒｆシステムへのｍｒｉ起源の干渉を回避するためのシステムおよび方法 |
| US10549128B2 (en) | 2015-11-04 | 2020-02-04 | Vytronus, Inc. | Systems and methods for imaging and ablating tissue |
| KR20180116345A (ko) | 2016-02-23 | 2018-10-24 | 서니브룩 리서치 인스티튜트 | 경두개 진단 및 치료 절차를 위한 환자 맞춤형 헤드셋 |
| WO2020113083A1 (en) | 2018-11-28 | 2020-06-04 | Histosonics, Inc. | Histotripsy systems and methods |
-
2016
- 2016-06-23 JP JP2017566835A patent/JP6979882B2/ja active Active
- 2016-06-23 WO PCT/US2016/039020 patent/WO2016210133A1/en active Application Filing
- 2016-06-23 ES ES16815301T patent/ES2948135T3/es active Active
- 2016-06-23 CN CN201680045860.4A patent/CN108348772B/zh active Active
- 2016-06-23 EP EP16815301.3A patent/EP3313517B1/en active Active
- 2016-06-23 EP EP23169575.0A patent/EP4230262A3/en active Pending
- 2016-06-23 US US15/737,761 patent/US11135454B2/en active Active
-
2018
- 2018-12-23 HK HK18116478.7A patent/HK1257321A1/zh unknown
-
2021
- 2021-08-20 US US17/407,780 patent/US20220219019A1/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732031A (zh) * | 2002-12-23 | 2006-02-08 | 因赛泰克-特克斯索尼克斯公司 | 超声波治疗中的组织偏差校正 |
| US20060173387A1 (en) * | 2004-12-10 | 2006-08-03 | Douglas Hansmann | Externally enhanced ultrasonic therapy |
| CN201197744Y (zh) * | 2008-01-30 | 2009-02-25 | 贾红 | 大鼠脑核团定位损毁仪 |
| CN102292123A (zh) * | 2008-11-19 | 2011-12-21 | 因赛泰克有限公司 | 闭环凝块消散 |
| CN102665585A (zh) * | 2009-10-09 | 2012-09-12 | 伊西康内外科公司 | 用于超声装置和用于电外科装置的外科发生器 |
| CN103648361A (zh) * | 2011-05-13 | 2014-03-19 | 直观外科手术操作公司 | 提供用于图像引导的外科手术的解剖结构的模型的动态配准的医疗系统 |
| CN104135938A (zh) * | 2012-02-23 | 2014-11-05 | 日立阿洛卡医疗株式会社 | 超声波诊断装置和超声波探头 |
| CN103537016A (zh) * | 2012-07-13 | 2014-01-29 | 重庆融海超声医学工程研究中心有限公司 | 超声换能器焦点的校正方法、装置及超声治疗设备 |
| CN103812477A (zh) * | 2012-11-12 | 2014-05-21 | 财团法人工业技术研究院 | 超声波发射电路及其时间延迟校正方法 |
| CN104013444A (zh) * | 2014-06-23 | 2014-09-03 | 南京广慈医疗科技有限公司 | 一种相控阵高强度聚焦超声消融系统 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113171156A (zh) * | 2021-04-23 | 2021-07-27 | 清华大学 | 植入式医疗器械的超声除栓配件 |
| CN113171156B (zh) * | 2021-04-23 | 2022-09-06 | 北京荷清和创医疗科技有限公司 | 植入式医疗器械的超声除栓配件 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180154186A1 (en) | 2018-06-07 |
| EP3313517B1 (en) | 2023-06-07 |
| WO2016210133A1 (en) | 2016-12-29 |
| EP4230262A2 (en) | 2023-08-23 |
| JP2018519061A (ja) | 2018-07-19 |
| ES2948135T3 (es) | 2023-08-31 |
| EP4230262A3 (en) | 2023-11-22 |
| WO2016210133A8 (en) | 2017-02-09 |
| EP3313517A1 (en) | 2018-05-02 |
| US20220219019A1 (en) | 2022-07-14 |
| CN108348772B (zh) | 2020-03-03 |
| JP6979882B2 (ja) | 2021-12-15 |
| EP3313517A4 (en) | 2019-01-09 |
| HK1257321A1 (zh) | 2019-10-18 |
| US11135454B2 (en) | 2021-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108348772A (zh) | 用于治疗脑组织的组织摧毁术治疗系统和方法 | |
| US20210330294A1 (en) | Systems and methods for performing transcranial ultrasound therapeutic and imaging procedures | |
| US10575816B2 (en) | Cavitation localization | |
| CN104884127B (zh) | 用于使用磁共振引导的聚焦超声的高温处置的多焦点声处理 | |
| US7587291B1 (en) | Focusing of broadband acoustic signals using time-reversed acoustics | |
| US20120143100A1 (en) | Extended depth-of-focus high intensity ultrasonic transducer | |
| US10806952B2 (en) | Therapeutic ultrasound apparatus and method | |
| US20150258352A1 (en) | Frequency compounding ultrasound pulses for imaging and therapy | |
| CN106730424A (zh) | 共焦谐波叠加百微秒脉冲超声组织毁损模式控制方法 | |
| US11273331B2 (en) | Systems and methods for high intensity focused ultrasound | |
| US20240091565A1 (en) | Pre-treatment tissue sensitization for focused ultrasound procedures | |
| CN107261344B (zh) | 一种用于声动力治疗的超声自适应聚焦方法 | |
| CN111494817B (zh) | 一种hifu设备大焦域形成系统及其焦域形成方法 | |
| JP2008272504A (ja) | 超音波治療装置 | |
| CN104353196A (zh) | 高强度超声经颅聚焦的幅值调制方法 | |
| US20150335918A1 (en) | Ultrasonic probe having gradient information and device for ultrasonic diagnosis and treatment using same | |
| Jeong et al. | Dual-focus therapeutic ultrasound transducer for production of broad tissue lesions | |
| US20200330114A1 (en) | Therapeutic ultrasonic device and the use thereof | |
| Gao et al. | Effect of focus splitting on ultrasound propagation through the rib cage in focused ultrasound surgery | |
| Chen et al. | A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers | |
| Son et al. | Flat HIFU transducer with a sawtooth-shaped ultrasound radiation face |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1257321 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Michigan, USA Patentee after: University of Michigan Board of Directors Address before: Michigan, USA Patentee before: THE REGENTS OF THE UNIVERSTIY OF MICHIGAN |
|
| CP01 | Change in the name or title of a patent holder |