CN108285482A - 经修饰松弛素多肽及其用途 - Google Patents
经修饰松弛素多肽及其用途 Download PDFInfo
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- CN108285482A CN108285482A CN201810035655.0A CN201810035655A CN108285482A CN 108285482 A CN108285482 A CN 108285482A CN 201810035655 A CN201810035655 A CN 201810035655A CN 108285482 A CN108285482 A CN 108285482A
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- Prior art keywords
- relaxin
- polypeptide
- amino acid
- substituted
- alkylene
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| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| ES2742296T3 (es) | 2010-08-17 | 2020-02-13 | Ambrx Inc | Polipéptidos de relaxina modificados y sus usos |
| AU2012280474A1 (en) | 2011-07-01 | 2014-01-16 | Bayer Intellectual Property Gmbh | Relaxin fusion polypeptides and uses thereof |
| US10493131B2 (en) * | 2011-08-31 | 2019-12-03 | University Of Florida Research Foundation, Incorporated | Materials and methods for modulating activity of bone marrow derived cells |
| US9393288B2 (en) * | 2012-05-29 | 2016-07-19 | The University Of Vermont And State Agricultural College | Methods of treating diseases associated with PPARγ |
| AR094147A1 (es) * | 2012-12-27 | 2015-07-15 | Bayer Pharma Aktiengellschaft | Polipeptidos de fusion con actividad de relaxina y sus usos |
| JP6822839B2 (ja) * | 2013-09-13 | 2021-01-27 | ザ・スクリップス・リサーチ・インスティテュート | 修飾された治療剤、及びその組成物 |
| CN106456589B (zh) | 2013-12-18 | 2020-07-07 | 斯克利普斯研究所 | 修饰的治疗剂、订合的肽脂质缀合物及其组合物 |
| MA41794A (fr) * | 2015-03-18 | 2018-01-23 | The California Institute For Biomedical Res | Agents thérapeutiques modifiés et compositions associées |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| PH12021550850A1 (en) | 2015-03-27 | 2022-10-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various tumors |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| IL263079B2 (en) | 2016-05-18 | 2024-05-01 | Modernatx Inc | Polynucleotides encoding relaxin |
| DK3522911T3 (da) * | 2016-10-07 | 2022-03-07 | Beth Israel Deaconess Medical Ct Inc | Sammensætninger omfattende relaxin og fremgangsmåder til anvendelse deraf |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| CN110225924B (zh) * | 2017-01-25 | 2024-04-02 | 免疫医疗有限公司 | 松弛素融合多肽及其用途 |
| KR102670432B1 (ko) | 2017-02-08 | 2024-05-28 | 브리스톨-마이어스 스큅 컴퍼니 | 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 |
| CA3061340A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| TW202434620A (zh) | 2019-07-31 | 2024-09-01 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| JP7516061B2 (ja) * | 2020-02-18 | 2024-07-16 | ポーラ化成工業株式会社 | 血管収縮抑制剤 |
| CN114075276A (zh) * | 2020-08-17 | 2022-02-22 | 成都奥达生物科技有限公司 | 一种长效松弛素2类似物 |
| JP2024522196A (ja) | 2021-06-09 | 2024-06-11 | ザ スクリプス リサーチ インスティテュート | 長時間作用型デュアルｇｉｐ／ｇｌｐ－１ペプチドコンジュゲートおよび使用方法 |
| WO2024238955A2 (en) | 2023-05-18 | 2024-11-21 | Tectonic Therapeutic, Inc. | Relaxin-2 fusion protein analogs and methods of using same |
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