KR101963460B1 - 변형된 릴랙신 폴리펩타이드 및 그것의 용도 - Google Patents

변형된 릴랙신 폴리펩타이드 및 그것의 용도 Download PDF

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KR101963460B1
KR101963460B1 KR1020137006654A KR20137006654A KR101963460B1 KR 101963460 B1 KR101963460 B1 KR 101963460B1 KR 1020137006654 A KR1020137006654 A KR 1020137006654A KR 20137006654 A KR20137006654 A KR 20137006654A KR 101963460 B1 KR101963460 B1 KR 101963460B1
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polypeptide
amino acid
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KR20130136450A (ko
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바딤 크레이노브
닉 크누드센
암하 헤웨트
크리스틴 데 디오스
제이슨 핑크스태프
로레인 설리반
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암브룩스, 인코포레이티드
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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  • Cardiology (AREA)
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  • Molecular Biology (AREA)
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KR1020137006654A 2010-08-17 2011-08-17 변형된 릴랙신 폴리펩타이드 및 그것의 용도 Active KR101963460B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37458210P 2010-08-17 2010-08-17
US61/374,582 2010-08-17
PCT/US2011/048157 WO2012024452A2 (en) 2010-08-17 2011-08-17 Modified relaxin polypeptides and their uses

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Publication Number Publication Date
KR20130136450A KR20130136450A (ko) 2013-12-12
KR101963460B1 true KR101963460B1 (ko) 2019-03-28

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US (6) US8735539B2 (enExample)
EP (3) EP4302783A3 (enExample)
JP (1) JP6054294B2 (enExample)
KR (1) KR101963460B1 (enExample)
CN (2) CN108285482A (enExample)
AU (1) AU2011291943B2 (enExample)
BR (1) BR112013003522B1 (enExample)
CA (1) CA2808596C (enExample)
CL (2) CL2013000475A1 (enExample)
CO (1) CO6680644A2 (enExample)
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EA (1) EA030886B1 (enExample)
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FI (1) FI3572091T3 (enExample)
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HR (2) HRP20191564T1 (enExample)
HU (2) HUE065900T2 (enExample)
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LT (2) LT2605789T (enExample)
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RS (2) RS65223B1 (enExample)
SG (3) SG187736A1 (enExample)
SI (2) SI2605789T1 (enExample)
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US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
ES2742296T3 (es) 2010-08-17 2020-02-13 Ambrx Inc Polipéptidos de relaxina modificados y sus usos
AU2012280474A1 (en) 2011-07-01 2014-01-16 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
US10493131B2 (en) * 2011-08-31 2019-12-03 University Of Florida Research Foundation, Incorporated Materials and methods for modulating activity of bone marrow derived cells
US9393288B2 (en) * 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
AR094147A1 (es) * 2012-12-27 2015-07-15 Bayer Pharma Aktiengellschaft Polipeptidos de fusion con actividad de relaxina y sus usos
JP6822839B2 (ja) * 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
CN106456589B (zh) 2013-12-18 2020-07-07 斯克利普斯研究所 修饰的治疗剂、订合的肽脂质缀合物及其组合物
MA41794A (fr) * 2015-03-18 2018-01-23 The California Institute For Biomedical Res Agents thérapeutiques modifiés et compositions associées
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
PH12021550850A1 (en) 2015-03-27 2022-10-03 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various tumors
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
IL263079B2 (en) 2016-05-18 2024-05-01 Modernatx Inc Polynucleotides encoding relaxin
DK3522911T3 (da) * 2016-10-07 2022-03-07 Beth Israel Deaconess Medical Ct Inc Sammensætninger omfattende relaxin og fremgangsmåder til anvendelse deraf
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN110225924B (zh) * 2017-01-25 2024-04-02 免疫医疗有限公司 松弛素融合多肽及其用途
KR102670432B1 (ko) 2017-02-08 2024-05-28 브리스톨-마이어스 스큅 컴퍼니 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
CA3061340A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
TW202434620A (zh) 2019-07-31 2024-09-01 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
JP7516061B2 (ja) * 2020-02-18 2024-07-16 ポーラ化成工業株式会社 血管収縮抑制剤
CN114075276A (zh) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 一种长效松弛素2类似物
JP2024522196A (ja) 2021-06-09 2024-06-11 ザ スクリプス リサーチ インスティテュート 長時間作用型デュアルｇｉｐ／ｇｌｐ－１ペプチドコンジュゲートおよび使用方法
WO2024238955A2 (en) 2023-05-18 2024-11-21 Tectonic Therapeutic, Inc. Relaxin-2 fusion protein analogs and methods of using same

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