CN108138130A - 多能干细胞制造系统和生产诱导多能干细胞的方法 - Google Patents

多能干细胞制造系统和生产诱导多能干细胞的方法 Download PDF

Info

Publication number
CN108138130A
CN108138130A CN201680050145.XA CN201680050145A CN108138130A CN 108138130 A CN108138130 A CN 108138130A CN 201680050145 A CN201680050145 A CN 201680050145A CN 108138130 A CN108138130 A CN 108138130A
Authority
CN
China
Prior art keywords
cell
stem cell
cells
culture
floating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680050145.XA
Other languages
English (en)
Chinese (zh)
Inventor
田边刚士
布兰登·凯莉
须藤健太
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epping World Co ltd
Original Assignee
Epping World Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epping World Co ltd filed Critical Epping World Co ltd
Priority to CN202210349694.4A priority Critical patent/CN114717183B/zh
Publication of CN108138130A publication Critical patent/CN108138130A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Thermal Sciences (AREA)
  • Hematology (AREA)
  • Computer Hardware Design (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Developmental Biology & Embryology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN201680050145.XA 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法 Pending CN108138130A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210349694.4A CN114717183B (zh) 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015-170797 2015-08-31
JP2015170797 2015-08-31
US201662356199P 2016-06-29 2016-06-29
US62/356,199 2016-06-29
PCT/US2016/049530 WO2017040548A1 (en) 2015-08-31 2016-08-30 Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210349694.4A Division CN114717183B (zh) 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法

Publications (1)

Publication Number Publication Date
CN108138130A true CN108138130A (zh) 2018-06-08

Family

ID=58188066

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201680050145.XA Pending CN108138130A (zh) 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法
CN202210349694.4A Active CN114717183B (zh) 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法
CN201810580097.6A Expired - Fee Related CN108823062B (zh) 2015-08-31 2016-08-31 细胞团分割器
CN202211151066.1A Pending CN115478045A (zh) 2015-08-31 2016-08-31 用于制作诱导多能干细胞的方法
CN201680050144.5A Pending CN108138113A (zh) 2015-08-31 2016-08-31 多能性干细胞制造系统

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202210349694.4A Active CN114717183B (zh) 2015-08-31 2016-08-30 多能干细胞制造系统和生产诱导多能干细胞的方法
CN201810580097.6A Expired - Fee Related CN108823062B (zh) 2015-08-31 2016-08-31 细胞团分割器
CN202211151066.1A Pending CN115478045A (zh) 2015-08-31 2016-08-31 用于制作诱导多能干细胞的方法
CN201680050144.5A Pending CN108138113A (zh) 2015-08-31 2016-08-31 多能性干细胞制造系统

Country Status (7)

Country Link
US (5) US11286454B2 (https=)
EP (4) EP3344755A4 (https=)
JP (7) JP7370529B2 (https=)
CN (5) CN108138130A (https=)
CA (2) CA2996582A1 (https=)
SG (1) SG11201801549VA (https=)
WO (2) WO2017040548A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110066733A (zh) * 2019-05-29 2019-07-30 广东唯泰生物科技有限公司 干细胞培养机器人
CN111666895A (zh) * 2020-06-08 2020-09-15 上海市同济医院 基于深度学习的神经干细胞分化方向预测系统及方法
CN113265333A (zh) * 2021-06-23 2021-08-17 无锡生基医药科技有限公司 一种全封闭、半自动化控制、模块化的质粒瞬时转染系统
CN113785049A (zh) * 2019-06-10 2021-12-10 爱平世股份有限公司 红细胞除去装置、单核细胞回收器、细胞培养装置、细胞培养系统、细胞培养方法及单核细胞的回收方法

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108138130A (zh) 2015-08-31 2018-06-08 爱平世股份有限公司 多能干细胞制造系统和生产诱导多能干细胞的方法
EP3541922A4 (en) 2016-11-18 2020-06-03 New York Stem Cell Foundation, Inc. MICROFLUIDIC SYSTEM AND METHOD FOR USE THEREOF
EP3556842A4 (en) * 2017-01-20 2020-01-15 FUJIFILM Corporation CELL CULTURE APPARATUS AND METHOD
CA3054119A1 (en) * 2017-02-24 2018-08-30 I Peace, Inc. Cell treatment device, suspension culture vessel, and stem cell induction method
CN110352238A (zh) * 2017-02-24 2019-10-18 田边刚士 诱导性多能干细胞的制作方法
US20190382706A1 (en) * 2017-02-27 2019-12-19 Koji Tanabe Somatic cell production system
CN115247129A (zh) 2017-02-27 2022-10-28 田边刚士 细胞处理装置
TWI862477B (zh) * 2017-05-26 2024-11-21 美商凱特製藥公司 製備和使用胚胎間充質先驅細胞的方法
JP7114693B2 (ja) * 2017-08-24 2022-08-08 テルモ ビーシーティー、インコーポレーテッド 細胞増殖
KR102503086B1 (ko) * 2017-09-08 2023-02-23 가부시키가이샤 오츠카 세이야쿠 고죠 어린 돼지 유래 줄기 세포 및 그 제조 방법
JPWO2019131626A1 (ja) * 2017-12-28 2020-12-10 オリンパス株式会社 細胞培養制御方法、細胞培養制御装置、細胞培養装置および細胞培養システム
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system
CN112055744A (zh) * 2018-02-09 2020-12-08 环球生命科技咨询美国有限责任公司 用于在生物处理系统中的流体管线管理的装置
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
JP6939643B2 (ja) * 2018-02-26 2021-09-22 株式会社Ihi 細胞分割装置及び細胞培養装置
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12385001B2 (en) * 2018-06-19 2025-08-12 Stemcell Technologies Canada Inc. Systems, methods and apparatus for the automated culture of cells
WO2020017411A1 (ja) * 2018-07-17 2020-01-23 国立大学法人神戸大学 固液界面検出装置及びこれを備えた前処理装置
DK3778860T3 (da) * 2018-07-24 2026-04-20 Fujifilm Corp Driftsprogram til cellekulturhjælpeapparat, cellekulturhjælpeapparat og driftsfremgangsmåde til cellekulturhjælpeapparat
EP3842513A4 (en) * 2018-08-20 2022-06-29 I Peace, Inc. Cell incubator
WO2020040135A1 (ja) * 2018-08-20 2020-02-27 剛士 田邊 細胞の培養又は誘導方法
WO2020044984A1 (ja) * 2018-08-27 2020-03-05 富士フイルム株式会社 細胞培養方法及び細胞培養装置
US11692161B2 (en) 2019-02-05 2023-07-04 Corning Incorporated Packed-bed bioreactor systems and methods of using the same
JP2020167959A (ja) * 2019-04-04 2020-10-15 オリンパス株式会社 培地モニタリング装置
WO2020196490A1 (ja) * 2019-03-25 2020-10-01 テルモ株式会社 細胞培養物を清浄度の高い空間において調製するための容器及びキット
JP7483687B2 (ja) * 2019-03-27 2024-05-15 株式会社カネカ 細胞製造装置、細胞製造方法並びにこれに用いられるサーバ、システムおよび装置
CN113811597B (zh) * 2019-06-28 2024-06-18 爱平世股份有限公司 细胞培养装置的应用
JP7037141B2 (ja) * 2019-06-28 2022-03-16 アイ ピース，インコーポレイテッド 細胞塊分割器、細胞塊分割器の製造方法、及び細胞塊の分割方法
CN110229751A (zh) * 2019-07-17 2019-09-13 中国人民解放军军事科学院军事医学研究院 mRNA制备系统及制备方法
US20220356436A1 (en) * 2019-08-29 2022-11-10 Fanuc Corporation Cell production device
WO2021038998A1 (ja) * 2019-08-29 2021-03-04 ファナック株式会社 細胞製造装置及びそのシステム
WO2021038996A1 (ja) * 2019-08-29 2021-03-04 ファナック株式会社 細胞製造装置及びその製造方法
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
JP7656868B2 (ja) * 2019-11-06 2025-04-04 アイ ピース，インコーポレイテッド 細胞培養装置
CN111126329A (zh) * 2019-12-30 2020-05-08 杭州原生生物科技有限公司 一种自动识别多能干细胞群的方法
JPWO2021166227A1 (https=) * 2020-02-21 2021-08-26
AU2021273985A1 (en) * 2020-05-22 2022-12-22 Sqz Biotechnologies Company Point of care system for automatically processing cells
JP7682619B2 (ja) 2020-10-19 2025-05-26 キヤノンメディカルシステムズ株式会社 誘導多能性幹細胞樹立装置及び方法
WO2022139950A1 (en) * 2020-12-23 2022-06-30 Cedars-Sinai Medical Center Methods for differentiation of pancreatic exocrine cells from human induced pluripotent stem cells
JP7744155B2 (ja) * 2021-04-19 2025-09-25 キヤノンメディカルシステムズ株式会社 多能性幹細胞製造システム
WO2022244670A1 (ja) * 2021-05-18 2022-11-24 国立大学法人京都大学 多能性幹細胞の製造方法
WO2023034720A1 (en) * 2021-08-28 2023-03-09 Cornell University Compositions and methods for cell reprogramming
WO2023053220A1 (ja) * 2021-09-28 2023-04-06 公益財団法人京都大学ｉＰＳ細胞研究財団 多能性幹細胞の製造方法
US20230130734A1 (en) * 2021-10-27 2023-04-27 Regenerative Research Foundation Cell culture feeding device
JP7836751B2 (ja) * 2022-12-15 2026-03-27 ヤマハ発動機株式会社 組換えタンパク質産生細胞の培養方法
WO2024176440A1 (ja) * 2023-02-24 2024-08-29 公益財団法人京都大学ｉＰＳ細胞研究財団 人工多能性幹細胞の製造方法
CN116426573A (zh) * 2023-04-14 2023-07-14 臻赫医药(杭州)有限公司 重编程因子抗衰老表达系统、生物材料及用途
JP7721836B1 (ja) * 2023-12-04 2025-08-12 公益財団法人京都大学ｉＰＳ細胞研究財団 人工多能性幹細胞の製造方法
CN118460359B (zh) * 2024-07-10 2024-09-20 江苏颐泽生物科技有限公司 一种具有细胞活性检测功能的干细胞贮存装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096614A1 (en) * 2008-01-30 2009-08-06 Mirae Biotech Co., Ltd. Method of manufacturing induced pluripotent stem cell originated from somatic cell
US20110281281A1 (en) * 2010-05-12 2011-11-17 Ipierian, Inc. Integration-free human induced pluripotent stem cells from blood
CN103380212A (zh) * 2010-12-22 2013-10-30 菲特治疗公司 用于单细胞分选与增强ipsc重新编程的细胞培养平台
US20140106348A1 (en) * 2012-07-24 2014-04-17 Kyoto University Culture medium composition and method of culturing cell or tissue using thereof
US8716465B2 (en) * 2010-04-16 2014-05-06 Children's Medical Center Corporation Kit for making induced pluripotent stem cells using modified RNAs

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258795B1 (en) * 1986-08-27 1993-11-03 Kawasumi Laboratories, Inc. A method for cultivating cells and an instrument therefor
US5399493A (en) * 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
CA2183638C (en) * 1995-03-20 2001-03-20 Precision System Science Co., Ltd Liquid processing method making use of pipette device and apparatus for same
CN1609593B (zh) 1996-08-16 2012-04-25 Ge保健尼亚加拉公司 用于分析井板、凝胶和斑点的数字成像系统
TWI288779B (en) 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
JP4309815B2 (ja) 2004-07-05 2009-08-05 株式会社日立製作所 細胞培養システム及び細胞培養方法
CN101443444A (zh) 2004-12-29 2009-05-27 比奥根艾迪克Ma公司 生物反应器过程控制系统及方法
CN100335612C (zh) * 2005-01-20 2007-09-05 上海交通大学 植物细胞或组织两段连续培养系统
CN1664545A (zh) * 2005-03-18 2005-09-07 宁波美生医疗器材有限公司 一种细胞薄层涂片的制作方法
JP2007000038A (ja) 2005-06-22 2007-01-11 Toray Ind Inc 閉鎖系循環回路型培養装置
CN2841667Y (zh) * 2005-09-09 2006-11-29 刘平 细胞滤过器
US20070087437A1 (en) * 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
WO2008136729A1 (en) * 2007-05-04 2008-11-13 Sundstroem Erik Slicing device
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US8815585B2 (en) 2007-06-29 2014-08-26 Cellular Dynamics International, Inc. Automated method and apparatus for embryonic stem cell culture
US7858371B2 (en) * 2007-09-26 2010-12-28 Weyerhaeuser Nr Company Method of separating embryo suspension mass
US9683232B2 (en) * 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
EP2238236B1 (fr) 2008-01-09 2017-03-29 Screencell Dispositif et procédé pour isoler et cultiver des cellules vivantes sur filtre ou extraire leur matériel génétique
US10047346B2 (en) * 2008-08-08 2018-08-14 Mayo Foundation For Medical Education And Research Method of treating heart tissue using induced pluripotent stem cells
EP2881461A1 (en) * 2008-11-21 2015-06-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Reprogramming cells toward a pluripotent state
WO2010141320A1 (en) * 2009-06-01 2010-12-09 Mariposa Biotechnology, Inc. Device for removing cumulus from oocytes
DK2438160T3 (en) 2009-06-05 2016-01-11 Cellular Dynamics Int Inc Reprogramming of T cells and hematopoietic cells
US8927287B2 (en) * 2009-10-09 2015-01-06 Georgia Tech Research Corporation Method for dispersion of assemblies of biological material
EP3633025B1 (en) * 2009-11-12 2022-09-14 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
EP2528687B1 (en) * 2010-01-29 2018-08-22 Micronics, Inc. System comprising a host instrument and a microfluidic cartridge for assays
EP2603517B1 (en) * 2010-05-12 2023-07-19 Cellectis Dynamic mixing and electroporation chamber and system
CA2810488C (en) * 2010-09-07 2025-05-06 Technion Research & Development Foundation Limited NEW PROCESSES AND CULTURE MEDIA FOR THE CULTURE OF MULTIPOTENTED STEM CELLS
US20160272934A1 (en) * 2010-10-08 2016-09-22 Cellanyx Diagnostics, Llc Systems, devices and methods for microfluidic culturing, manipulation and analysis of tissues and cells
CN102559587A (zh) * 2010-12-16 2012-07-11 中国科学院上海药物研究所 诱导性多能干细胞的制备方法以及用于制备诱导性多能干细胞的培养基
CN102174395B (zh) 2011-01-30 2013-08-21 中国科学院广州生物医药与健康研究院 诱导多能干细胞自动化扩增与培养系统
WO2012115153A1 (ja) 2011-02-25 2012-08-30 株式会社ニコン 細胞評価方法、細胞培養方法、細胞評価装置、インキュベータ、細胞評価プログラム、コロニー分類プログラム、幹細胞の培養方法、幹細胞評価装置および幹細胞評価プログラム
GB201105413D0 (en) * 2011-03-30 2011-05-11 Cambridge Entpr Ltd Nuclear reprogramming substrate
AU2012243396A1 (en) * 2011-04-15 2013-10-31 The University Of British Columbia Method and apparatus for separation of particles
CN107058101B (zh) * 2011-10-17 2021-06-01 麻省理工学院 细胞内传递
WO2013058403A1 (ja) 2011-10-21 2013-04-25 国立大学法人京都大学 層流による多能性維持単一分散細胞培養法
EP2594632A1 (en) * 2011-11-18 2013-05-22 Miltenyi Biotec GmbH Method and device for cell modification
US20140329317A1 (en) * 2011-11-25 2014-11-06 Kyoto University Method for culturing pluripotent stem cell
WO2013082509A1 (en) * 2011-12-01 2013-06-06 The New York Stem Cell Foundation Automated system for producing induced pluripotent stem cells or differentiated cells
US10428309B2 (en) * 2011-12-01 2019-10-01 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells and differentiated cells
TWI582233B (zh) * 2011-12-15 2017-05-11 陶氏農業科學公司 使用農桿菌改良轉形的方法
JP5274731B1 (ja) 2011-12-22 2013-08-28 三洋電機株式会社 観察システム、プログラム及び観察システムの制御方法
WO2013136372A1 (ja) 2012-03-16 2013-09-19 株式会社日立製作所 細胞シート、細胞培養方法および細胞培養装置
WO2013177228A1 (en) * 2012-05-22 2013-11-28 Loma Linda University Generation of integration/transgene-free stem cells
EP2861612A4 (en) 2012-06-13 2016-02-17 Stemgent Inc METHOD FOR PRODUCING PLURIPOTENT STEM CELLS
IL300460A (en) * 2012-07-24 2023-04-01 Nissan Chemical Corp A culture medium preparation, and a method for culturing cells or tissues by using the preparation
AU2013343864B2 (en) * 2012-11-09 2019-04-04 BioNTech SE Method for cellular RNA expression
US9738861B2 (en) 2013-03-06 2017-08-22 Kyoto University Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
EP2970881A4 (en) * 2013-03-14 2017-01-25 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
CA2895638A1 (en) 2013-03-15 2014-09-18 Fluidigm Corporation Methods and devices for analysis of defined multicellular combinations
US10519421B2 (en) 2013-03-21 2019-12-31 Kyoto University Induction of motor neurons from pluripotent stem cells
WO2014171486A1 (ja) * 2013-04-17 2014-10-23 日産化学工業株式会社 培地組成物及び当該培地組成物を用いた赤血球の製造方法
US20150159127A1 (en) * 2013-05-10 2015-06-11 BioCapacity On Demand, LLC Mobile vessel or carrier for the manufacturing production, purification and sterile fill and finish of biologics
EP3008174A4 (en) * 2013-06-11 2017-03-08 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US9580678B2 (en) * 2013-06-21 2017-02-28 The Regents Of The University Of California Microfluidic tumor tissue dissociation device
EP3048169B1 (en) 2013-09-04 2019-07-10 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JP5751726B2 (ja) 2013-11-12 2015-07-22 東京エレクトロン株式会社 多能性幹細胞の培養方法及び施設
TWI708846B (zh) 2014-01-23 2020-11-01 日商日產化學工業股份有限公司 培養基組成物的製造方法
CN112662611B (zh) 2014-01-23 2024-10-29 日产化学工业株式会社 培养基组合物
US10100286B2 (en) * 2014-06-20 2018-10-16 The Board Of Trustees Of The University Of Alabama Systems and methods of dissociating aggregate spheres of cells
US20170355950A1 (en) * 2014-12-04 2017-12-14 The Arizona Board Of Regents On Behalf Of The University Of Arizona Systems for dissociation of biological tissues
JP6291429B2 (ja) 2015-01-20 2018-03-14 富士フイルム株式会社 細胞培養装置および細胞培養方法
US10350245B2 (en) * 2015-01-21 2019-07-16 Fred Hutchinson Cancer Research Center Point-of-care and/or portable platform for gene therapy
US10836997B2 (en) 2015-03-09 2020-11-17 Keio University Method for differentiating pluripotent stem cells into desired cell type
CN108138130A (zh) 2015-08-31 2018-06-08 爱平世股份有限公司 多能干细胞制造系统和生产诱导多能干细胞的方法
KR102802007B1 (ko) * 2016-06-08 2025-04-28 더 리전트 오브 더 유니버시티 오브 캘리포니아 조직 및 세포를 프로세싱하기 위한 방법 및 장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096614A1 (en) * 2008-01-30 2009-08-06 Mirae Biotech Co., Ltd. Method of manufacturing induced pluripotent stem cell originated from somatic cell
US8716465B2 (en) * 2010-04-16 2014-05-06 Children's Medical Center Corporation Kit for making induced pluripotent stem cells using modified RNAs
US20110281281A1 (en) * 2010-05-12 2011-11-17 Ipierian, Inc. Integration-free human induced pluripotent stem cells from blood
CN103380212A (zh) * 2010-12-22 2013-10-30 菲特治疗公司 用于单细胞分选与增强ipsc重新编程的细胞培养平台
US20140106348A1 (en) * 2012-07-24 2014-04-17 Kyoto University Culture medium composition and method of culturing cell or tissue using thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
L. B. UJAM等: "Isolation of monocytes from human peripheral blood using immuno‐affinity expanded-bed adsorption", 《BIOTECHNOL BIOENG》 *
SOHAM CHANDA等: "Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1", 《STEM CELL REPORTS》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110066733A (zh) * 2019-05-29 2019-07-30 广东唯泰生物科技有限公司 干细胞培养机器人
CN113785049A (zh) * 2019-06-10 2021-12-10 爱平世股份有限公司 红细胞除去装置、单核细胞回收器、细胞培养装置、细胞培养系统、细胞培养方法及单核细胞的回收方法
US12454681B2 (en) 2019-06-10 2025-10-28 I Peace, Inc. Erythrocyte removal device, mononuclear cell collector, cell culture device, cell culture system, cell culture method, and mononuclear cell collection method
CN113785049B (zh) * 2019-06-10 2025-11-25 爱平世股份有限公司 细胞培养方法及单核细胞的回收方法
CN111666895A (zh) * 2020-06-08 2020-09-15 上海市同济医院 基于深度学习的神经干细胞分化方向预测系统及方法
CN113265333A (zh) * 2021-06-23 2021-08-17 无锡生基医药科技有限公司 一种全封闭、半自动化控制、模块化的质粒瞬时转染系统

Also Published As

Publication number Publication date
WO2017040548A1 (en) 2017-03-09
CN115478045A (zh) 2022-12-16
CA2996988A1 (en) 2017-03-09
US10508260B2 (en) 2019-12-17
SG11201801549VA (en) 2018-03-28
EP3366763A3 (en) 2019-02-20
EP3473703A2 (en) 2019-04-24
CN114717183A (zh) 2022-07-08
EP3344755A1 (en) 2018-07-11
CN108138113A (zh) 2018-06-08
EP3345990A1 (en) 2018-07-11
JP7370529B2 (ja) 2023-10-30
JP2022088643A (ja) 2022-06-14
JP2017221187A (ja) 2017-12-21
CN108823062A (zh) 2018-11-16
US20180273891A1 (en) 2018-09-27
CN108823062B (zh) 2019-12-27
JP7351483B2 (ja) 2023-09-27
JP6253216B2 (ja) 2017-12-27
JP2020036607A (ja) 2020-03-12
EP3473703A3 (en) 2019-07-17
EP3344755A4 (en) 2019-05-22
US20220389368A1 (en) 2022-12-08
JP2018526992A (ja) 2018-09-20
JP6283904B2 (ja) 2018-02-28
US20190338237A1 (en) 2019-11-07
EP3366763B1 (en) 2023-11-15
US20180245041A1 (en) 2018-08-30
JP2017221186A (ja) 2017-12-21
WO2017038887A1 (ja) 2017-03-09
JP6198203B2 (ja) 2017-09-20
CN114717183B (zh) 2024-11-29
US11518974B2 (en) 2022-12-06
EP3366763A2 (en) 2018-08-29
US20220119758A1 (en) 2022-04-21
US11286454B2 (en) 2022-03-29
JPWO2017038887A1 (ja) 2017-08-31
CA2996582A1 (en) 2017-03-09
EP3345990A4 (en) 2019-02-20
US11912977B2 (en) 2024-02-27
JP2017195905A (ja) 2017-11-02

Similar Documents

Publication Publication Date Title
US20220119758A1 (en) Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells
CN114807035B (zh) 临床级别视网膜色素上皮细胞的可再现的分化方法
CN108291206B (zh) 干细胞来源的视网膜色素上皮的基于macs的纯化
US20230002717A1 (en) Somatic cell production system
CN112601813A (zh) 细胞的培养或诱导方法
JPWO2015199127A1 (ja) 中胚葉細胞および造血細胞の製造方法
US20230220344A1 (en) Induced pluripotent cell comprising a controllable transgene for conditional immortalisation
JP2023011942A (ja) 神経系細胞の作製方法
JP2014060991A (ja) 多孔質中空糸の内腔を用いる幹細胞の培養方法
JP2020036608A (ja) 多能性幹細胞製造システム、幹細胞の誘導方法、幹細胞の浮遊培養方法、幹細胞の浮遊培養器、人工多能性幹細胞の作製方法、及び動物細胞から特定の体細胞を作製する方法
JP2019080575A (ja) 体細胞製造システム
US20230055044A1 (en) Method for manufacturing induced pluripotent stem cells
CN116583595A (zh) 培养构件及其用途
HK40067121B (zh) 多能干细胞制造系统和生产诱导多能干细胞的方法
HK40067121A (en) Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells
WO2024177018A1 (ja) 人工多能性幹細胞の製造方法
HK40043180A (zh) 细胞的培养或诱导方法
Wang Scalable expansion and erythrocyte production of human induced pluripotent stem cells

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1252090

Country of ref document: HK

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1252090

Country of ref document: HK