CN108137579B - 桥连哌啶衍生物 - Google Patents

桥连哌啶衍生物 Download PDF

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Publication number
CN108137579B
CN108137579B CN201680057010.6A CN201680057010A CN108137579B CN 108137579 B CN108137579 B CN 108137579B CN 201680057010 A CN201680057010 A CN 201680057010A CN 108137579 B CN108137579 B CN 108137579B
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CN
China
Prior art keywords
triazolo
azabicyclo
pyridin
amine
octan
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CN201680057010.6A
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English (en)
Chinese (zh)
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CN108137579A (zh
Inventor
比约恩·巴特尔斯
卡尔海因茨·博伊曼
吉多·加利
乔治·耶施克
罗兰·雅各布-勒特
安雅·林贝格
维尔纳·奈德哈特
哈萨内·拉特尼
罗莎·马丽亚·罗得里格斯-萨尔米恩托
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN108137579A publication Critical patent/CN108137579A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680057010.6A 2015-12-10 2016-12-06 桥连哌啶衍生物 Active CN108137579B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15199260 2015-12-10
EP15199260.9 2015-12-10
PCT/EP2016/079816 WO2017097728A1 (en) 2015-12-10 2016-12-06 Bridged piperidine derivatives

Publications (2)

Publication Number Publication Date
CN108137579A CN108137579A (zh) 2018-06-08
CN108137579B true CN108137579B (zh) 2022-01-07

Family

ID=54848457

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680057010.6A Active CN108137579B (zh) 2015-12-10 2016-12-06 桥连哌啶衍生物

Country Status (7)

Country Link
US (2) US10562903B2 (enExample)
EP (1) EP3386978B1 (enExample)
JP (1) JP6872550B2 (enExample)
CN (1) CN108137579B (enExample)
AR (1) AR107010A1 (enExample)
TW (1) TWI629278B (enExample)
WO (1) WO2017097728A1 (enExample)

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SMT202100506T1 (it) 2015-10-02 2021-11-12 Hoffmann La Roche Anticorpi bispecifici specifici per pd1 e tim3
CN110946865B (zh) 2015-12-10 2024-01-26 Ptc医疗公司 用于治疗亨廷顿病的方法
EP3475279B1 (en) * 2016-06-27 2021-07-14 F. Hoffmann-La Roche AG Triazolopyridines as gamma-secretase modulators
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
EP3535266B1 (en) * 2016-11-01 2021-12-29 F. Hoffmann-La Roche AG Bicyclic heteroaryl derivatives
KR20190121816A (ko) 2017-04-03 2019-10-28 에프. 호프만-라 로슈 아게 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
PL3606955T3 (pl) 2017-04-05 2025-02-24 F. Hoffmann-La Roche Ag Przeciwciała dwuswoiste swoiście wiążące się z PD1 i LAG3
EP3634953B1 (en) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
WO2020048904A1 (en) 2018-09-03 2020-03-12 F. Hoffmann-La Roche Ag Bicyclic heteroaryl derivatives
SI3894411T1 (sl) * 2018-12-13 2024-10-30 F. Hoffmann - La Roche Ag Derivati 7-fenoksi-N-(3-azabiciklo(3.2.1)oktan-8-il)-6,7-dihidro-5H- pirolo(1,2-b)(1,2,4)triazol-2-amina in sorodne spojine kot modulatorji gama-sekretaze za zdravljenje Alzheimerjeve bolezni
JP2022515610A (ja) 2018-12-27 2022-02-21 エフ．ホフマン－ラ ロシュ アーゲー ｅｘｏ－ｔｅｒｔ－ブチルＮ－（３－アザビシクロ［３．２．１］オクタン－８－イル）カルバミン酸塩の調製のためのプロセス
CN114245794B (zh) 2019-05-13 2024-09-13 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
WO2022238816A1 (en) * 2021-05-14 2022-11-17 Bm Pharma Consulting Pty. Ltd Bicyclic heterocyclic compounds for prophylaxis and treatment of viral infections

Citations (3)

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EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

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GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
KR20060127909A (ko) 2003-12-24 2006-12-13 비오타 사이언티픽 매니지먼트 피티와이 엘티디 호흡기 다핵체 바이러스 감염 치료용 다환 물질
FR2914188B1 (fr) 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
US8633019B2 (en) 2008-05-27 2014-01-21 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
JP2011529722A (ja) 2008-08-14 2011-12-15 カーディアック ペースメイカーズ， インコーポレイテッド 音響通信リンクの性能評価および適合
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
GB201119538D0 (en) 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
USRE47689E1 (en) 2011-12-30 2019-11-05 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
ES2733644T3 (es) 2012-01-26 2019-12-02 Ptc Therapeutics Inc Compuestos para tratar atrofia muscular espinal
JP6092897B2 (ja) 2012-02-10 2017-03-08 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
WO2014012050A2 (en) 2012-07-13 2014-01-16 Indiana University Research & Technology Corporation Compounds for treatment of spinal muscular atrophy
WO2014184163A1 (en) 2013-05-14 2014-11-20 F. Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
RU2673542C2 (ru) 2013-06-25 2018-11-28 Ф. Хоффманн-Ля Рош Аг Соединения для лечения спинальной мышечной атрофии
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
DK3143025T3 (da) 2014-05-15 2019-12-09 Hoffmann La Roche Forbindelser til behandling af spinal muskelatrofi
JP6659841B2 (ja) 2015-11-12 2020-03-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 脊髄性筋萎縮症を処置するための組成物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947098A1 (en) * 2005-10-06 2008-07-23 Nippon Soda Co., Ltd. Cyclic amine compounds and pest control agent
CN103025724A (zh) * 2010-02-17 2013-04-03 霍夫曼-拉罗奇有限公司 哌啶衍生物
CN103403003A (zh) * 2011-03-02 2013-11-20 霍夫曼-拉罗奇有限公司 桥连哌啶衍生物

Also Published As

Publication number Publication date
US10562903B2 (en) 2020-02-18
EP3386978A1 (en) 2018-10-17
CN108137579A (zh) 2018-06-08
EP3386978B1 (en) 2021-01-27
TW201725209A (zh) 2017-07-16
JP6872550B2 (ja) 2021-05-19
JP2018536671A (ja) 2018-12-13
US20190010156A1 (en) 2019-01-10
WO2017097728A1 (en) 2017-06-15
AR107010A1 (es) 2018-03-14
US20200291034A1 (en) 2020-09-17
TWI629278B (zh) 2018-07-11

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