AR107010A1 - Derivados de piperidina puenteados - Google Patents

Derivados de piperidina puenteados

Info

Publication number
AR107010A1
AR107010A1 ARP160103753A ARP160103753A AR107010A1 AR 107010 A1 AR107010 A1 AR 107010A1 AR P160103753 A ARP160103753 A AR P160103753A AR P160103753 A ARP160103753 A AR P160103753A AR 107010 A1 AR107010 A1 AR 107010A1
Authority
AR
Argentina
Prior art keywords
halogen
lower alkyl
alkyl substituted
substituted
hydrogen
Prior art date
Application number
ARP160103753A
Other languages
English (en)
Spanish (es)
Inventor
Ratni Hasane
Limberg Anja
Jaeschke Georg
Baumann Karlheinz
Maria Rodriguez Sarmiento Rosa
Neidhart Werner
Jakob-Roetne Roland
Galley Guido
Bartels Bjoern
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR107010A1 publication Critical patent/AR107010A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP160103753A 2015-12-10 2016-12-07 Derivados de piperidina puenteados AR107010A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15199260 2015-12-10

Publications (1)

Publication Number Publication Date
AR107010A1 true AR107010A1 (es) 2018-03-14

Family

ID=54848457

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103753A AR107010A1 (es) 2015-12-10 2016-12-07 Derivados de piperidina puenteados

Country Status (7)

Country Link
US (2) US10562903B2 (enExample)
EP (1) EP3386978B1 (enExample)
JP (1) JP6872550B2 (enExample)
CN (1) CN108137579B (enExample)
AR (1) AR107010A1 (enExample)
TW (1) TWI629278B (enExample)
WO (1) WO2017097728A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20180773A1 (es) 2015-10-02 2018-05-07 Hoffmann La Roche Anticuerpos biespecificos para pd1 y tim3
CN108697709A (zh) 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
EP3475279B1 (en) * 2016-06-27 2021-07-14 F. Hoffmann-La Roche AG Triazolopyridines as gamma-secretase modulators
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
AR110001A1 (es) * 2016-11-01 2019-02-13 Hoffmann La Roche Derivados heteroarilo bicíclicos
PT3606946T (pt) 2017-04-03 2022-10-17 Hoffmann La Roche Imunoconjugados de um anticorpo anti-pd-1 com uma il-2 mutante ou com il-15
CN116375876A (zh) 2017-04-05 2023-07-04 豪夫迈·罗氏有限公司 特异性结合pd1和lag3的双特异性抗体
AU2018282154B2 (en) 2017-06-05 2022-04-07 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
WO2020005877A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
HUE064554T2 (hu) 2018-09-03 2024-03-28 Hoffmann La Roche Bicikluszos heteroaril származékok
PL3894411T3 (pl) 2018-12-13 2024-10-07 F. Hoffmann-La Roche Ag Pochodne 7-fenoksy-N-(3-azabicyklo[3.2.1]oktan-8-ylo)-6,7-dihydro-5H-pirolo[1,2-b][1,2,4]triazolo-2-aminy i związki pokrewne jako modulatory gamma-sekretazy do leczenia choroby Alzheimera
AU2019412747B8 (en) 2018-12-27 2025-04-24 F. Hoffmann-La Roche Ag Process for the preparation exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate
CN117396490A (zh) * 2021-05-14 2024-01-12 Bm医药咨询有限公司 用于预防和治疗病毒感染的双环杂环化合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
ES2360222T3 (es) 2003-12-24 2011-06-02 Biota Scientific Management Pty. Ltd. Agentes policíclicos para el tratamiento de infecciones respiratorias por virus sincicial.
CA2624558C (en) * 2005-10-06 2011-02-22 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
FR2914188B1 (fr) 2007-03-28 2012-06-22 Trophos Nouvelle composition a base d'oxime de cholest-4-en-3-one
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
EP2337609B1 (en) 2008-08-14 2016-08-17 Cardiac Pacemakers, Inc. Performance assessment and adaptation of an acoustic communication link
US8486967B2 (en) * 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US8703763B2 (en) * 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
GB201119538D0 (en) 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
WO2013101974A1 (en) 2011-12-30 2013-07-04 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
BR112014018027B1 (pt) 2012-01-26 2020-10-27 Ptc Therapeutics, Inc composto, composição farmacêutica e usos dos mesmos e métodos para aumentar a inclusão de éxon 7 de ame2 em rnam que é transcrito a partir do gene ame2 e para aumentar a quantidade de proteína smn
EP2812004B1 (en) 2012-02-10 2018-06-27 PTC Therapeutics, Inc. Compounds for treating spinal muscular atrophy
WO2014012050A2 (en) 2012-07-13 2014-01-16 Indiana University Research & Technology Corporation Compounds for treatment of spinal muscular atrophy
MX2015015691A (es) 2013-05-14 2016-03-04 Hoffmann La Roche Aza-oxo-indoles novedosos para el tratamiento y profilaxis de la infeccion del virus sincital respiratorio.
MX363456B (es) 2013-06-25 2019-03-25 Hoffmann La Roche Compuestos para tratar atrofia muscular espinal.
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
HRP20230637T1 (hr) 2014-05-15 2023-09-29 F. Hoffmann - La Roche Ag Postupak za proizvodnju spojeva korisnih za liječenje spinalne mišićne atrofije
KR102162062B1 (ko) 2015-11-12 2020-10-07 에프. 호프만-라 로슈 아게 척수성 근위축증의 치료용 조성물

Also Published As

Publication number Publication date
WO2017097728A1 (en) 2017-06-15
CN108137579A (zh) 2018-06-08
EP3386978B1 (en) 2021-01-27
JP6872550B2 (ja) 2021-05-19
TW201725209A (zh) 2017-07-16
EP3386978A1 (en) 2018-10-17
TWI629278B (zh) 2018-07-11
US20200291034A1 (en) 2020-09-17
CN108137579B (zh) 2022-01-07
US20190010156A1 (en) 2019-01-10
JP2018536671A (ja) 2018-12-13
US10562903B2 (en) 2020-02-18

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