CN108026512B - 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 - Google Patents
具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 Download PDFInfo
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- CN108026512B CN108026512B CN201680049392.8A CN201680049392A CN108026512B CN 108026512 B CN108026512 B CN 108026512B CN 201680049392 A CN201680049392 A CN 201680049392A CN 108026512 B CN108026512 B CN 108026512B
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211000656.4A CN116064401A (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
| CN202210987123.3A CN116064400B (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178899.9 | 2015-07-29 | ||
| EP15178899 | 2015-07-29 | ||
| GB1603655.0 | 2016-03-02 | ||
| GBGB1603655.0A GB201603655D0 (en) | 2016-03-02 | 2016-03-02 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| GB201605457 | 2016-03-31 | ||
| GB1605457.9 | 2016-03-31 | ||
| GBGB1610164.4A GB201610164D0 (en) | 2016-06-10 | 2016-06-10 | Modified natural killer cells and natural killer cell lines having increased cytoxicity |
| GB1610164.4 | 2016-06-10 | ||
| PCT/EP2016/068001 WO2017017184A1 (en) | 2015-07-29 | 2016-07-28 | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211000656.4A Division CN116064401A (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
| CN202210987123.3A Division CN116064400B (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108026512A CN108026512A (zh) | 2018-05-11 |
| CN108026512B true CN108026512B (zh) | 2022-09-16 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680049392.8A Active CN108026512B (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
| CN202210987123.3A Active CN116064400B (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
| CN202211000656.4A Pending CN116064401A (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210987123.3A Active CN116064400B (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
| CN202211000656.4A Pending CN116064401A (zh) | 2015-07-29 | 2016-07-28 | 具有增强的细胞毒性的修饰的天然杀伤细胞和天然杀伤细胞系 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10034925B2 (enExample) |
| EP (6) | EP3971284B1 (enExample) |
| JP (3) | JP6974681B2 (enExample) |
| KR (1) | KR20180028530A (enExample) |
| CN (3) | CN108026512B (enExample) |
| AU (2) | AU2016300128B2 (enExample) |
| BR (1) | BR112018001660A2 (enExample) |
| CA (2) | CA3156128A1 (enExample) |
| DK (3) | DK3421590T3 (enExample) |
| ES (5) | ES2970269T3 (enExample) |
| HK (1) | HK1252582B (enExample) |
| MX (2) | MX380813B (enExample) |
| WO (1) | WO2017017184A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10066207B2 (en) | 2012-04-18 | 2018-09-04 | Board Of Trustees Of Michigan State University | Natural killer cells with enhanced immune response |
| US10906951B2 (en) | 2015-07-29 | 2021-02-02 | Onk Therapeutics Limited | Modified natural killer cells and natural killer cell lines having increased cytotoxicity |
| JP6974681B2 (ja) * | 2015-07-29 | 2021-12-01 | オーエヌケー セラピューティクス リミテッド | 細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| US10799536B2 (en) | 2016-12-09 | 2020-10-13 | Onk Therapeutics Limited | Method of treating multiple myeloma using natural killer cells expressing a chimeric antigen receptor for CD38 |
| IL267543B2 (en) * | 2017-01-06 | 2024-07-01 | Immunitybio Inc | Modified nk-92 cells and compositions thereof for use in the treatment of cancer and methods of preparation thereof |
| EP3580341A4 (en) * | 2017-02-09 | 2020-11-04 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| DE102017002645A1 (de) * | 2017-03-17 | 2018-09-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Bestrahlung von Säugetierzellen mit Elektronenstrahlen und/oder Röntgenstrahlen |
| US11903968B2 (en) | 2017-07-21 | 2024-02-20 | Cellectis | Engineered immune cells resistant to tumor microenvironment |
| WO2019016360A1 (en) * | 2017-07-21 | 2019-01-24 | Cellectis | MODIFIED IMMUNE CELLS RESISTANT TO TUMOR MICRO-ENVIRONMENT |
| JP2021503954A (ja) * | 2017-11-24 | 2021-02-15 | オーエヌケイ セラピューティクス リミテッド | 腫瘍細胞を標的とする改変されたナチュラルキラー細胞およびナチュラルキラー細胞株 |
| CN113518826A (zh) * | 2018-05-16 | 2021-10-19 | 全国儿童医院研究所 | 利用cas9核糖核蛋白来产生敲除的原代和扩增的人nk细胞 |
| US20210230542A1 (en) * | 2018-06-06 | 2021-07-29 | Stemcell Technologies Canada Inc. | Kits, compositions and methods for cell enrichment |
| CN108743595B (zh) * | 2018-06-08 | 2020-11-27 | 厦门诺康得生物科技有限公司 | 一种nk细胞免疫检查点抑制剂及其制备方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| BR112021010297A2 (pt) | 2018-11-28 | 2021-08-24 | Board Of Regents, The University Of Texas System | Edição de genomas multiplexadores de células imunes para aumentar a funcionalidade e resistência ao ambiente supressivo |
| MX2021009742A (es) * | 2019-02-15 | 2021-12-10 | Editas Medicine Inc | Celulas asesinas naturales (nk) modificadas para inmunoterapia. |
| CN109908155A (zh) * | 2019-03-11 | 2019-06-21 | 上海中医药大学 | 丹参酮ⅱa的药物用途 |
| WO2020189942A1 (ko) * | 2019-03-15 | 2020-09-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| KR102292657B1 (ko) | 2019-03-15 | 2021-08-24 | 한국과학기술연구원 | 암 상살 능력이 향상된 면역세포 |
| MX2021011373A (es) * | 2019-03-21 | 2022-01-06 | Onk Therapeutics Ltd | Celulas efectoras inmunitarias modificadas con mayor resistencia a la muerte celular. |
| EP3712257A1 (en) | 2019-03-21 | 2020-09-23 | ONK Therapeutics Limited | Modified natural killer cells with increased resistance to cell death |
| CN109970869A (zh) * | 2019-04-12 | 2019-07-05 | 南京卡提医学科技有限公司 | 一种靶向人trail死亡受体的嵌合受体配体及其应用 |
| RU2731293C1 (ru) | 2019-04-12 | 2020-09-01 | Игорь Петрович Белецкий | Способ получения генно-модифицированных линий клеток натуральных киллеров с нокаутированным геном PD-1 и повышенной экспрессией белков семейства Фактора Некроза Опухолей для иммунотерапии онкологических заболеваний |
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