CN107875393A - 一种含片矫味剂及其制备方法 - Google Patents
一种含片矫味剂及其制备方法 Download PDFInfo
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- CN107875393A CN107875393A CN201610878910.9A CN201610878910A CN107875393A CN 107875393 A CN107875393 A CN 107875393A CN 201610878910 A CN201610878910 A CN 201610878910A CN 107875393 A CN107875393 A CN 107875393A
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- lozenge
- flavouring
- acid
- carbonate
- chinese medicine
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Abstract
本发明提供一种含片矫味剂及其制备方法。该含片矫味剂由下列重量百分含量的原料配置而成：赋形剂70～95％、聚乙二醇0.1～10％、碳酸盐0.5～5％、有机酸0.5～5％、甜味剂0.1～5％、香精0.1～3％、薄荷脑0.05～1％，且上述各原料的重量百分比之和为100％。该含片矫味剂的制备方法简单可行，利于工业化生产。本发明提供的含片矫味剂，尤其可以用于主药成分来自那些可能会有特殊味道或口感的原料，以改善或屏蔽含片中主药的特殊味道，尤其对于主药成分来自于药食同源、保健食品以及新资源食品原料的中药含片，具有很好的矫味效果，不仅提升了含服过程中的愉悦感，而且促进了服用者对主药成分的均匀摄取与吸收。
Description
技术领域
本发明涉及一种含片矫味剂及其制备方法，尤其涉及一种主药成分来自于药食同源、保健食品以及新资源食品原料的含片用矫味剂。
背景技术
酸、苦、甘、辛、咸，是中药药性五味，药食的滋味主要是通过口尝而得知。由于药食“入口则知味，入腹则知性”，因此古人很自然地将滋味与作用联系起来，并用滋味解释药食的作用，这就是最初的“滋味说”。但是，在中药服用过程中，中药的特殊味道很容易引起味觉逆反，进而影响服用者的服药顺应性。
针对上述问题，传统的做法，是在药物片剂外侧包裹糖衣或将药物装入胶囊中，口服时可掩盖药物的不良味道，或者通过在药物颗粒中掺杂矫味剂颗粒或加入大量的蔗糖，以掩盖中药颗粒在冲服时的特殊味道。
但是上述做法，均不适用于含片，尤其是在中药含片(中药口含片)的服用过程中，药物在口腔内缓慢溶解，多种味道差异很大或味道无法调和的中药成分滞留于口腔和咽部，会对口腔及咽部产生持久的效果，令服用者难以接受，因此，十分需要一种含片矫味剂，以有效掩盖或改善中药含片的特殊味道，甚至提升服用过程的愉悦感，从而提高服用者的用药顺应性。
随着食品加工业向医药和保健品业延伸，更多具有药食同源性质的材料不仅用于药品和食品加工，也用于了供消费者日常食用和保健的产品，例如，压片糖虽然属于糖果范畴，但引入一些具有药食同源性的原料制成含片，既可以作为糖果食用消遣，也可以对于一些口腔或肌体不适辅助调节。近年来这种形式的“糖果”已经很受市场的欢迎，但从口味被接受度考虑，对使用的主成分选择还是比较局限，原因也是在于一些原料本身的特殊味道和口感使产品与多数消费者适应和接受程度之间的差距。
发明内容
本发明提供一种含片矫味剂及其制备方法，通过合理调配原料组成及配比，使制备的含片矫味剂可协调或遮盖含片的特殊味道。
为解决上述技术问题，本发明提供了一种含片矫味剂，由下列重量百分含量的原料配置而成：
赋形剂70～95％、聚乙二醇0.1～10％、碳酸盐0.5～5％、有机酸0.5～5％、甜味剂0.1～5％、香精0.1～3％、薄荷脑0.05～1％，且上述各原料的重量百分比之和为100％。
本发明的含片矫味剂尤其可以用于主药成分来自那些可能会有特殊味道或口感的原料，对于口味起到良好的协调或遮盖效果，使制作的含片“亦糖亦药”。
本发明中所选用的聚乙二醇的数均分子量可以大于1000，一般选择数均分子量为1000～10000的聚乙二醇，比如选择聚乙二醇4000(PEG 4000)、聚乙二醇6000(PEG 6000)、聚乙二醇8000(PEG 8000)等，也可以是两种或多种分子量的聚乙二醇混合物，如聚乙二醇4000与聚乙二醇6000的混合物。
本发明中所选用的赋形剂，可以是下述中的至少一种：淀粉、甘露醇、赤藓糖醇、木糖醇、山梨醇、麦芽糖醇、乳糖、果糖、蔗糖、葡萄糖、微晶纤维素、糊精，也可以是本领域常用的其他赋形剂，以不影响主药成分的疗效为准，并综合考虑赋形剂的稳定性、副作用、是否含糖等因素。
本发明中所用碳酸盐与有机酸的重量之和为1.0～10％，适当含量的碳酸盐与有机酸的体系能使添加了该矫味剂的含片在口中有较理想的释放弥漫感，例如使碳酸盐与有机酸的含量之和为大约5～10％。
进一步的，可以使碳酸盐与有机酸重量比为1：2～2：1，比如1：1～1：2。
本发明中所选用的碳酸盐，可以是下述中的至少一种：碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钾、碳酸氢氨、碳酸氨，也可以是本领域常用的其它碳酸盐。
本发明中所用的有机酸，可以是下述中的至少一种：酒石酸、苹果酸、柠檬酸、富马酸、马来酸、果酸、琥珀酸，也可以是本领域常用的其它有机酸。
本发明中所用的甜味剂，可以是下述中的至少一种：甜菊糖(甜菊苷)、甘草酸二钠、甘草酸三钠、甘草酸三钾、竹芋甜素、糖精、邻苯甲酰磺酰亚胺钠(糖精钠)、环己基氨基磺酸钠(甜蜜素)、天门冬酰苯丙氨酸甲酯(甜味素、阿斯巴甜、阿司帕坦)、乙酰磺胺酸钾(安赛蜜)、三氯蔗糖(蔗糖素)等。
糖精钠是食品工业中使用历史最长的甜味剂，其甜度为蔗糖的200～700倍；甜蜜素的甜度为蔗糖的50倍左右，甜味纯正且风味良好；阿斯巴甜的甜度为蔗糖的200倍左右，可被人体消化吸收，但高温加热后易失去甜味；安赛蜜的甜度为蔗糖的200倍左右，稳定性较好，无热量，不参与人体内的代谢，适合糖尿病人、肥胖病患者或老年人；蔗糖素是以蔗糖为原料合成的甜味剂，甜度为蔗糖的600倍，在人体内吸收率较小。糖醇类甜味剂，其甜度低于蔗糖，如山梨糖醇、麦芽糖醇、异麦芽酮糖、木糖醇、乳糖醇、左旋甘露糖醇。非糖天然甜味剂，安全性较好，如甜菊糖(甜菊糖甙)、罗汉果甜苷、甘草酸二钠、甘草酸三钾等。其中，甜菊糖的甜度为蔗糖的250～450倍，食用后不被吸收，不产生热能，适合糖尿病患者和肥胖病患者使用；甘草酸二钠的甜度是蔗糖的200～300倍，有浓郁的甘草特殊香味，无杂质和怪味，口感好，具有低热能、安全无毒和较强的医疗保健功效，是高血压、肥胖症、糖尿病、心脏病患者使用的最理想甜味剂。本发明中的含片矫味剂，可根据甜度、热量、安全性等因素选择上述任一一种或多种甜味剂，也可以选择本领域常用的其它甜味剂。
本发明提供的含片矫味剂，可作为中药含片的辅料，用于掩盖或改善中药含片中主药成分的特殊味道，具体的，可根据主药成分的味道、功效及服用者情况，合理选择含片矫味剂的原料成份并调整配比，比如用于糖尿病患者或肥胖症患者的含片矫味剂，应选择具有低热能的矫味剂原料；若主药成分的味道较苦，则可选择甜度较高的甜味剂或适当提高甜味剂的含量，并通过调节碳酸盐与有机酸的比重，使添加了该矫味剂的中药含片在口中有较理想的释放弥漫感，达到最佳的矫味效果。
根据所选择主药成分特点，本发明的矫味剂还可以用于压片糖等含食糖果中，将对口腔或胃肠道等器官具有调理保健效果的食用材料加工成压片糖类糖果产品，供消费者作为例如随身携带的消遣零食，同时满足了娱乐与保健需要。
本发明还提供上述含片矫味剂的制备方法，包括以下步骤：
将有机酸、甜味剂、部分赋形剂混合均匀，制成软材，造粒，得颗粒A；
将聚乙二醇、碳酸盐、余量赋形剂混合均匀，制成软材，造粒，得颗粒B；
将颗粒A、颗粒B、香精、薄荷脑混合均匀，得到含片矫味剂。
在本发明一实施例中，颗粒A的制备，是将有机酸、甜味剂、部分赋形剂混合均匀后，制成软材，并经造粒、整粒即得。颗粒B的制备，是将聚乙二醇、碳酸盐、余量的赋形剂混合均匀，制成软材，并经造粒、整粒即得。如果选择的聚乙二醇原料在常温下为固态，则需首先将聚乙二醇加热至熔融状，然后与碳酸盐和余量的赋形剂混合。
上述颗粒A和颗粒B的制备过程中，均可以根据实际需要加入适量的黏合剂，并按照制药技术的常规操作制成软材，然后造粒、整粒。所选用的黏合剂可以是水、乙醇或乙醇水溶液，也可选用聚乙烯吡咯烷酮(PVP)水溶液(一般浓度不超过20％)、羟丙基甲基纤维素(HPMC)、羟丙基纤维素(HPC)等。
颗粒A与颗粒B制备过程中，赋形剂的用量可以根据实际需要确定，通常颗粒A与颗粒B中赋形剂用量比为1：2～1：3，如1：2或1：3。
如前述，本发明提供了一种用于含片的矫味剂，根据含片的成分、功效不同，可以是一种药物含片，尤其是一种具有为保健目的食用的中药含片，也可以是一种作为糖果提供的压片糖产品。由于含片的主要成分均选择药食同源的中草药原料、可用于保健食品的中药原料，以及可作为新资源食品的植物中药原料，阅读本文可以理解，产品称为中药含片或压片糖可视为无区别，所以除有特殊说明，对于含片中除矫味剂外的主要成分，本发明均称为“主药成分”。
所以，本发明还提供一种中药含片，包括中药颗粒和上述含片矫味剂，且二者的重量比为1～30：100，例如5～30：100，优选5～20：100。
可采用制药领域常规的方法制备得到上述中药含片，在本发明一实施例中，首先将待服用的中药干膏粉制成中药颗粒，然后与上述含片矫味剂混合均匀，加入润滑剂，混合均匀后压片，即得到中药含片。所以，本发明中的含片矫味剂也可以作为中药含片的中间原料，直接向制药企业提供。
上述将中药干膏粉制成中药颗粒，可采用制药领域常规的制备方法，在本发明一实施例中，先将中药干膏粉制成软材，然后经造粒、整粒，即得到中药颗粒(也可视为压片糖的主料)。
本发明提供了一种含片矫味剂，通过对该矫味剂组成的特定设计与匹配，使其作为辅料，与主药成分一起制成中药含片(压片糖)。服用者在含服时，矫味剂成分在口中产生释放弥漫感，对主药成分的味道起到协调或遮盖的效果。同时，矫味剂成分的释放还会形成类似“泡腾”的效果，不仅提升了含服过程中的愉悦感，还能促进服用者对主药成分的均匀摄取和吸收。
本发明中的含片矫味剂，尤其适用于主药成分来自于天然原料药(中药)的含片制品。本发明中所述的“中药”，是指药食同源的中草药原料、可用于保健食品的中药原料，以及可作为新资源食品的植物中药原料，例如：
中华人民共和国国家卫生和计划生育委员会公布的既是食品又是药品(药食同源)的中草药：丁香、八角、茴香、刀豆、小茴香、小蓟、山药、山楂、马齿苋、乌梢蛇、乌梅、木瓜、火麻仁、代代花、玉竹、甘草、白芷、白果、白扁豆、白扁豆花、龙眼肉(桂圆)、决明子、百合、肉豆蔻、肉桂、余甘子、佛手、杏仁、沙棘、芡实、花椒、红小豆、阿胶、鸡内金、麦芽、昆布、枣(大枣、黑枣、酸枣)、罗汉果、郁李仁、金银花、青果、鱼腥草、姜(生姜、干姜)、枳椇子、枸杞子、栀子、砂仁、胖大海、茯苓、香橼、香薷、桃仁、桑叶、桑葚、桔红、桔梗、益智仁、荷叶、莱菔子、莲子、高良姜、淡竹叶、淡豆豉、菊花、菊苣、黄芥子、黄精、紫苏、紫苏籽、葛根、黑芝麻、黑胡椒、槐米、槐花、蒲公英、蜂蜜、榧子、酸枣仁、鲜白茅根、鲜芦根、蝮蛇、橘皮、薄荷、薏苡仁、薤白、覆盆子、藿香。
中华人民共和国国家卫生和计划生育委员会公布的可用于保健食品的中药：人参、人参叶、人参果、三七、土茯苓、大蓟、女贞子、山茱萸、川牛膝、川贝母、川芎、马鹿胎、马鹿茸、马鹿骨、丹参、五加皮、五味子、升麻、天门冬、天麻、太子参、巴戟天、木香、木贼、牛蒡子、牛蒡根、车前子、车前草、北沙参、平贝母、玄参、生地黄、生何首乌、白及、白术、白芍、白豆蔻、石决明、石斛、地骨皮、当归、竹茹、红花、红景天、西洋参、吴茱萸、怀牛膝、杜仲、杜仲叶、沙苑子、牡丹皮、芦荟、苍术、补骨脂、坷子、赤芍、远志、麦冬、龟甲、佩兰、侧柏叶、制大黄、制何首乌、刺五加、刺玫果、泽兰、泽泻、玫瑰花、玫瑰茄、知母、罗布麻、苦丁茶、金荞麦、金缨子、青皮、厚朴花、姜黄、枳壳、枳实、柏子仁、珍珠、绞股蓝、葫芦巴、茜草、筚茇、韭菜子、首乌藤、香附、骨碎补、党参、桑白皮、桑枝、浙贝母、益母草、积雪草、淫羊藿、菟丝子、野菊花、银杏叶、黄芪、湖北贝母、番泻叶、蛤蚧、越橘、槐实、蒲黄、蒺藜、蜂胶、酸角、墨旱莲、熟大黄、熟地黄、鳖甲。
中华人民共和国国家卫生和计划生育委员会公布的可作为新资源食品的植物中药：短梗五加、菊粉、白子菜、雨生红球藻、金花茶、显脉旋覆花(小黑药)、诺丽果浆、玛咖粉、人参(人工种植)、乌药叶、辣木叶、茶树花、阿萨伊果、丹凤牡丹花、狭基线纹香茶菜、青钱柳叶、显齿蛇葡萄叶、柳叶蜡梅、杜仲雄花、奇亚籽、圆苞车前子壳、线叶金雀花、枇杷叶、湖北海棠(茶海棠)叶、油菜花粉、玉米花粉、松花粉、向日葵花粉、紫云英花粉、荞麦花粉、芝麻花粉、高梁花粉、魔芋、钝顶螺旋藻、极大螺旋藻、刺梨、玫瑰茄、酸角、玫瑰花(重瓣红玫瑰)、凉粉草(仙草)、针叶樱桃果、平卧菊三七、大麦苗、梨果仙人掌(米邦塔品种)、沙棘叶、纳豆、木犀科粗壮女贞苦丁茶、柑橘纤维、玉米须、小麦苗、冬青科苦丁茶、牛蒡根、五指毛桃、耳叶牛皮消、白毛银露梅(华西银腊梅(药王茶)、夏枯草、布渣叶、鸡蛋花。
本发明中使用的中药干膏粉，是将上述中药原料或其组合经水提或水浸后，将提取液或浸液进行浓缩、干燥、粉碎后所得，商购、自制均可。
本发明中矫味剂所使用的组成原料，均为符合制药和食品领域相关安全法规的物质或试剂，均可商购得到。
本发明提供的含片矫味剂，具有很好的矫味效果，尤其可用于掩盖或改善药食同源、保健食品以及新资源食品原料来源的中药的特殊味道。本发明提供的含片矫味剂的制备方法简单可行，适合工业化生产。采用上述含片矫味剂作为辅料制得的中药含片(压片糖)，在含服过程中，由于含片矫味剂在口中产生释放弥漫感并产生类似“泡腾”的效果，不仅可以有效协调或遮盖主药成分的特殊味道，而且提升了含服过程中的愉悦感，在提高了服用者的用药顺应性的同时，还促进了服用者对主药成分的均匀摄取与吸收。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
1、含片矫味剂的原料
赤藓糖醇：867g、聚乙二醇6000：30g、碳酸氢钠：30g、酒石酸：50g、天门冬酰苯丙氨酸甲酯：10g、香草香精：10g、薄荷脑：3g。
2、含片矫味剂的制备
将酒石酸、天门冬酰苯丙氨酸甲酯、1/4量的赤藓糖醇混合，加适量90％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒A；
将聚乙二醇6000加热熔融，加入碳酸氢钠，搅拌均匀，冷却至室温粉碎，过80目筛，与3/4量的赤藓糖醇混合均匀，加适量90％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒B；
将颗粒A、颗粒B、香草香精、薄荷脑混合均匀后，即得含片矫味剂。
3、中药含片(压片糖)的制备
取大枣干膏粉10g、白芷干膏粉10g、益智仁干膏粉10g、百合干膏粉10g、甘草干膏粉18g、陈皮干膏粉10g、藿香干膏粉2g混合均匀，加适量80％体积浓度的乙醇制成软材，过18目筛造粒，干燥去除乙醇后过16目筛整粒，再与上述制得的全部含片矫味剂混合均匀，然后加入适量硬脂酸镁，混合均匀，压片即得中药含片(压片糖)。
对本实施例中制备的中药含片(压片糖)进行口感评价，评价指标包括甜度、酸度、香气、口感、中药味。具体评价方法为：由30位味觉正常的志愿者含服上述中药含片，并对上述各项评价指标进行打分，分数范围为0～9分，分数越高代表口感越好，其中，0～3分表示较难接受，4～6分表示接受度适中，7～9分表示较满意，打分结果参见下表，其中，表格中的数字代表给出对应分数的志愿者人数，各项指标的计算结果为全部志愿者的打分平均值。
| 维度 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 平均值 |
| 甜度 | 8 | 9 | 13 | 8.2 | |||||||
| 酸度 | 2 | 4 | 7 | 9 | 8 | 7.6 | |||||
| 香气 | 5 | 3 | 7 | 7 | 8 | 7.3 | |||||
| 口感 | 2 | 3 | 25 | 8.8 | |||||||
| 中药味 | 7 | 2 | 6 | 7 | 8 | 7.2 |
根据上述打分情况可知，本实施例中的含片矫味剂，可以有效遮盖中药的特殊味道，从而使制得的中药含片(压片糖)酸甜适中、具有淡淡的香气和中药味，口感良好。并且，在上述中药含片(压片糖)含服过程中，主药成分口腔中缓慢释放，并具有类似“泡腾”的感觉，令人愉悦。
实施例2
1、含片矫味剂的原料
甘露醇：826g、聚乙二醇4000：20g、聚乙二醇6000：20g、碳酸氢钾：40g、苹果酸：40g、甜菊糖：30g、玫瑰香精：20g、薄荷脑：4g。
2、含片矫味剂的制备
将苹果酸、甜菊糖、1/3量的甘露醇混合，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒A；
将聚乙二醇4000与聚乙二醇6000加热熔融，加入碳酸氢钾，搅拌均匀，冷却粉碎，过80目筛后与剩余的甘露醇混合均匀，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒B；
将颗粒A、颗粒B、玫瑰香精、薄荷脑混合均匀后，即得含片矫味剂。
3、中药含片的制备
取人参干膏粉20g、五味子干膏粉10g、远志干膏粉8g、熟地黄干膏粉10g、茯苓干膏粉20g混合，加适量水制成软材，过18目筛造粒，干燥后过16目筛整粒，再与上述制得的全部含片矫味剂混合均匀，然后加入适量硬脂酸镁，混合均匀，压片即得。
采用实施例1中的口感评价方法，计算中药含片的甜度为7.8，酸度为7.3，香气为7.6，口感为8.3，中药味为7.4。所以，本实施例中的含片矫味剂，可以有效遮盖中药的特殊味道，从而使制得的中药含片酸甜适中、具有淡淡的香气和中药味，口感良好。并且，在上述中药含片含服过程中，主药成分在口腔中缓慢释放，并具有类似“泡腾”的感觉，令人愉悦。
此外，上述含片矫味剂所用的赋形剂为甘露醇，是一种食糖代用品，所用的甜味剂为甜菊糖，食用后不被人体吸收，也不产生热能，其余原料也不产生热能，因此上述含片矫味剂也可应用于糖尿病或肥胖病患者服用的中药含片。
实施例3
1、含片矫味剂的原料
山梨糖醇：866g、聚乙二醇8000：30g、碳酸氢钠：30g、苹果酸：20g、柠檬酸20g、三氯蔗糖：10g、蓝莓香精：20g、薄荷脑：4g。
2、含片矫味剂的制备
将苹果酸、柠檬酸、三氯蔗糖、1/3量的山梨糖醇混合，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒A；
将聚乙二醇8000加热熔融，加入碳酸氢钠，搅拌均匀，冷却粉碎，过80目筛后与剩余的山梨糖醇混合均匀，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒B；
将颗粒A、颗粒B、蓝莓香精、薄荷脑混合均匀后，即得含片矫味剂。
3、中药含片(压片糖)的制备
取西洋参干膏粉25g、黄芪干膏粉25g、麦冬干膏粉40g、甘草干膏粉10g混合，加适量水制成软材，过18目筛造粒，干燥后过16目筛整粒，再与上述制得的全部含片矫味剂混合均匀，然后加入适量硬脂酸镁，混合均匀，压片即得。
采用实施例1中的口感评价方法，计算中药含片(压片糖)的甜度为8.1，酸度为7.7，香气为7.8，口感为7.9，中药味为7.2。所以，本实施例中的含片矫味剂，可以有效遮盖中药的特殊味道，从而使制得的中药含片(压片糖)酸甜适中、具有淡淡的香气和中药味，口感良好。并且，在上述中药含片含服过程中，主药成分在口腔中缓慢释放，并具有类似“泡腾”的感觉，令人愉悦。
实施例4
1、含片矫味剂的原料
山梨糖醇：826g、聚乙二醇6000：30g、碳酸氢钾：20g、碳酸氢钠：20g、苹果酸：40g、酒石酸：10g、阿司帕坦：30g、甜橙香精：20g、薄荷脑：4g。
2、含片矫味剂的制备
将苹果酸、酒石酸、三氯蔗糖、1/2量的山梨糖醇混合，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒A；
将聚乙二醇6000加热熔融，加入碳酸氢钾、碳酸氢黄，搅拌均匀，冷却粉碎，过80目筛后与剩余的山梨糖醇混合均匀，加适量95％乙醇制成软材，过18目筛造粒，干燥后过16目筛整粒，得颗粒B；
将颗粒A、颗粒B、甜橙香精、薄荷脑混合均匀后，即得含片矫味剂。
3、中药含片的制备
取玛咖粉50g、杜仲雄花干膏粉30g、蛹虫草粉50g混合，加适量水制成软材，过18目筛造粒，干燥后过16目筛整粒，再与上述制得的含片矫味剂混合均匀，然后加入适量硬脂酸镁，混合均匀，压片即得。
采用实施例1中的口感评价方法，计算中药含片的甜度为7.9分，酸度为7.5，香气为7.5，口感为8.4，中药味为7.5。所以，本实施例中的含片矫味剂，可以有效遮盖中药的特殊味道，从而使制得的中药含片酸甜适中、具有淡淡的香气和中药味，口感良好。并且，在上述中药含片含服过程中，主药成分在口腔中缓慢释放，并具有类似“泡腾”的感觉，令人愉悦。
最后应说明的是：以上各实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述各实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分或者全部技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (9)
1.一种含片矫味剂，其特征在于，由下列重量百分含量的原料配置而成：
赋形剂70～95％、聚乙二醇0.1～10％、碳酸盐0.5～5％、有机酸0.5～5％、甜味剂0.1～5％、香精0.1～3％、薄荷脑0.05～1％，且上述各原料的重量百分比之和为100％。
2.根据权利要求1所述的含片矫味剂，其特征在于，所述聚乙二醇的平均分子量大于1000。
3.根据权利要求1所述的含片矫味剂，其特征在于，所述赋形剂包括下述中的至少一种：淀粉、甘露醇、赤藓糖醇、木糖醇、山梨醇、麦芽糖醇、乳糖、果糖、蔗糖、葡萄糖、微晶纤维素、糊精。
4.根据权利要求1所述的含片矫味剂，其特征在于，所述碳酸盐与有机酸重量比为1：2～2：1。
5.根据权利要求1或4所述的含片矫味剂，其特征在于，所述碳酸盐包括下述中的至少一种：碳酸氢钠、碳酸钠、碳酸氢钾、碳酸钾、碳酸氢氨、碳酸氨。
6.根据权利要求1、4或5任一所述的含片矫味剂，其特征在于，所述有机酸包括下述中的至少一种：酒石酸、苹果酸、柠檬酸、富马酸、马来酸、果酸、琥珀酸。
7.根据权利要求1所述的含片矫味剂，其特征在于，所述甜味剂包括下述中的至少一种：甜菊糖、甘草酸二钠、甘草酸三钠、甘草酸三钾、竹芋甜素、糖精、糖精钠、环己基氨基磺酸钠、天门冬酰苯丙氨酸甲酯、乙酰磺胺酸钾、三氯蔗糖。
8.一种根据权利要求1-7任一项所述的含片矫味剂的制备方法，其特征在于，包括以下步骤：
将有机酸、甜味剂、部分赋形剂混合均匀，制成软材，造粒，得到颗粒A；
将聚乙二醇、碳酸盐、余量赋形剂混合均匀，制成软材，造粒，得到颗粒B；
将颗粒A、颗粒B、香精、薄荷脑混合均匀，得到所述含片矫味剂。
9.一种中药含片，包括中药颗粒和权利要求1-7任一项所述含片矫味剂，二者的重量比为1～30：100。
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| CN115089685A (zh) * | 2022-03-01 | 2022-09-23 | 江苏聚荣制药集团有限公司 | 一种无糖型安神补脑液及其制备方法 |
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