CN113016969A - 一种阴虚体质保健固体饮料及其制备方法 - Google Patents
一种阴虚体质保健固体饮料及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种阴虚体质保健固体饮料。它是由黑桑椹、黄精、黑果枸杞、黑果腺肋花揪、VB1，加辅料乳糖、麦芽糊精、异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷、蓝莓速溶粉制成，采用药学上可接受的载体或赋形剂制成的药剂，包括颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂等。具有滋补阴血、生津润燥、调节机体代谢、抗氧化之功效，适用于阴虚体质人群，以及有阴虚体质症状的人群服用，症见形体消瘦，两颧潮红，手足心热，潮热盗汗，心烦易怒，口干，头发、皮肤干枯，舌干红、少苔，甚至光滑无苔。临床使用表明本发明可改善阴虚体质的症状，未见不良反应。
Description
技术领域
本发明涉及一种阴虚体质保健固体饮料及其制备方法。
背景技术
阴虚体质是脏腑功能失调时，出现体内阴液不足，阴虚生内热的证候，常表现为形体消瘦，两颧潮红，手足心热，潮热盗汗，心烦易怒，口干，头发、皮肤干枯，舌干红、少苔，甚至光滑无苔。五脏阴虚在临床上均可见，除上述临床表现，同时并见各脏的相应病变而见不同症状。发病倾向：易患虚劳、失精、不寐等，耐冬不耐夏，不耐受暑、热、燥邪。
中医药在治疗阴虚体质方面积累了丰富经验，疗效确切，亟待研究开发。中医认为阴虚体质常因燥热之邪外侵、过食温燥之品、忧思过度、房事不节、久病之后等引起脏腑功能失调，阴液暗耗而成阴液亏少，阴虚生内热，表现机体失去濡润滋养，虚热干燥、虚火躁扰不宁的证候。治疗应以滋补阴液、佐以清热为治则，还应针对相关脏腑阴虚辨证，分别选用滋养五脏之阴液、佐以清五脏之虚热的方药，根据阴阳互根理论，加少量补阳之品。临床治疗以辨证论治为主，多以汤剂为主，使用不便。
本发明针对阴虚体质选用君药：黑桑椹滋补阴血、生津润燥。臣药：黄精补气养阴、健脾、润肺、益肾；黑果枸杞滋补肝肾、益精明目。佐使药：结合现代研究，阴虚体质多伴有体内代谢功能低下、对氧化物的清除力下降、脂质过氧化程度增强等。为此，选用黑果腺肋花揪（黑涩石楠）所含多酚、类黄酮、花青素是目前已知植物果实中含量最高的。还含有多种糖类、脂肪、挥发油、维生素A、维生素B1、维生素B2、钙、铁等人体必需的物质，调节机体代谢、抗氧化。另加入VB1（维生素B1）具有维持正常糖代谢及神经传导的功能。此外，为保证产品的剂型和口感，加入国际食品标准中允许加入的辅料，如乳糖、异麦芽酮糖醇、羧甲基纤维素钠。诸药合用，具有滋补阴血、生津润燥、调节机体代谢、抗氧化之功效。
本发明与现有阴虚体质专利技术比较如下。经检索中国知网专利库，涉及阴虚体质专利申请共50项，其申请（专利）号、名称和组方如下：（1）[申请号] CN201810354782.7一种用于改善阴虚体质的食品组合物，它是含有下述重量配比的原料制备而成：黄精50～300份、枸杞100～400份、肉桂20～150份。（2）[申请号] CN201910794989.0一种干预阴虚体质的中药组合物、破壁组合物及其制备方法和应用。所述中药组合物由如下质量份数的组分组成：桑椹6～13份，玉竹10～18份，枸杞子5～13份，山药6～14份，沙棘2～4份，陈皮0.5～2份，蜂蜜0.5～1.5份。（3）[申请号] CN201910096773.7一种调理阴虚体质的中药泡浴抑菌液/颗粒及制备与使用方法，所述中药泡浴抑菌液/颗粒的原料包括如下重量份的组分：首乌藤5-35 份，熟地黄5-35份，黄精5-35份，地榆5-35份，忍冬腾5-35份，银耳5-50份。（4）[申请号] CN201811305833.3一种改善阴虚体质的功能食品及其制备方法，由以下重量份原料提取制备：枸杞2-20份，山药2-20份，耳叶牛皮消2-20份，黄精1-15份，菊花1-15份。（5）[申请号] CN201811400041.4一种改善阴虚体质的养生膏，其特征在于取黄精、桑葚、山药、玉竹、百合、枸杞子、覆盆子、酸枣仁、芦根、炙甘草、银耳、黑木耳、莲子用水洗净、混合、煎煮得到比重为1.0-1.1的混合膏液，再将阿胶粉和异麦芽低聚糖粉放入混合膏液进行糊化，糊化温度90-95℃，糊化时间20-50分钟，然后在60-65℃的温度下均质2次，再将均质后的混合膏液进行高温灭菌，再经灌装封口、冷却、包装制成。（6）[申请号] CN201811411210.4一种改善阴虚体质的饼干生产方法，其特征在于以黄精、玉竹、百合、枸杞子、覆盆子、酸枣仁、芦根、炙甘草、银耳、黑木耳、莲子为原料制成的中药提取物，加以小麦粉、山药粉、桑葚粉、小苏打、食盐放入搅拌机中，加35-43℃水进行面团调制，形成面团后进行面团发酵，发酵完成后放入饼干成形机压延成型，再放入烤炉进行烘烤，出炉冷却后包装为成品。（7）[申请号]CN201710491302.7一种改善阴虚体质的食品，其特征在于包含：基质粉和体质粉；其中所述基质粉包含糙米、大豆蛋白粉、大豆膳食纤维、薏米、燕麦、小麦胚芽，所述体质粉包含玉竹、桑葚、莲子、百合、乌梅、枸杞、陈皮。（8）[申请号] CN201811071122.4一种针对阴虚体质人群的保健茶的制备方法，其特征在于，包括以下步骤：(1)将原料枸杞子、百合、南沙参、玉竹、铁皮石斛洗净除杂，备用；(2)分别取洗净除杂后的原料进行真空冷冻干燥，然后粉碎成颗粒；(3)将超微和田玉粉和步骤(2)所得的颗粒充分混合均匀，灭菌即得保健茶。（9）[申请号] CN201811079038.7一种调理阴虚体质的宣木瓜代用茶及其制备方法，它由如下优选重量份数的原料制备得到：宣木瓜30～38份、栀子15～20份、陈皮10～15份、玉竹8～10份、酸枣仁8～10份、鲜芦根7～9份、枸杞子6～8份、人参(人工种植)3～5份、砂仁1～3份，经粉碎、过筛、制粒、干燥、杀菌、装袋获得产品。（10）[申请号] CN201810712259.7一种阴虚体质调理足浴粉及其制备方法，涉及足浴粉领域。一种阴虚体质调理足浴粉，包括以下重量份数的原料：熟地20～40份，山茱萸20～40份，山药20～40份，泽泻20～40份，石斛10～30份，党参5～25份，五味子20～40份，丹皮5～25份。阴虚体质调理足浴分的制备方法，包括以下步骤：(1)原料预处理；(2)超声波提取；(3)浓缩、干燥；(4)粉碎、过筛；(5)混合；(6)灭菌。（11）[申请号] CN201810151671.6一种改善阴虚体质的黄精茶及其制备工艺。是以黄精、玉竹、枸杞、茯苓、橘皮、松花粉、山药、玫瑰、显齿蛇葡萄叶、葛根、青钱柳叶、桑叶、决明子组方为功能成分，以普通茶叶为基体成分，其制备方法包括黄精复方水提、浓缩、干燥、茶叶制备添加有效成份发酵。（12）[申请号] CN201711429037.6一种用于调理阴虚体质的中药膏方。该中药膏方包括以下重量份数的原料组分：北沙参10～30份、熟地黄2～25份、山茱萸5～25份、山药5～25份、丹皮6～16份、茯苓5～15份、天冬5～15份、五味子1～5份、枸杞5～15份、泽泻4～12份、银耳10～30份、佛手3～9份、白蒺藜6～24份、麦门冬5～15份、女贞子8～22份、砂仁1～5份、石斛10～30份、百合11～29份、当归5～15份、白芍7～23份、生甘草1～5份、玄参5～15份、浙贝母2～10份、玉竹5～15份、黑芝麻7～23份、桑葚子5～15份、鳖甲胶10～30份、龟板胶10～30份、阿胶4～17份、木糖醇20～40份、西洋参5～15份。（13）[申请号]CN201611067543.0一种阴虚体质食品配方，原料按照重量份数计算，比值分配包括：黄精10～35份、去芯莲子5～50份、百合10～30份、梨5～40份、淮山药10～55份、水溶性膳食纤维(低聚异麦芽糖)10～30份、水苏糖10～20份、黄原胶0.5～2份。（14）[申请号]CN201711240639.7一种用于调理阴虚体质的固体饮料。该固体饮料包括以下重量份数的原料组分：30～55份的乌梅、29～51份的百合、27～50份的玉竹、30～52份的桑叶、27～48份的桑葚、26～58份的鲜芦根、67～94份的牡蛎、3～15份的砂仁、27～50份的糊精、16～43份的麦芽糊精、38～70份的可溶性淀粉、0.15～0.35份的阿斯巴甜。（15）[申请号]CN201810058881.0一种调理阴虚体质的营养套餐，由苦瓜炒鸭丁、黄玉甲鱼、西芹百合炒口蘑、桑椹糕和芦根麦冬茶组成。（16）[申请号] CN201711129304.8一种药物组合物，它是由下述重量配比的原料药制备而成的制剂：黄精2～10份、阿胶1～5份、玉竹1～6份、百合1～5份、白茅根3～12份、芦根2～10份。（17）[申请号] CN201710697830.8针对阴虚体质按摩中药油乳，涉及中药油乳技术领域，其组分按重量份包括：沙参10～30份、五倍子20～40份、天冬门20～30份、丹皮20～40份、玉竹15～30份、石斛10～20份、百合15～40份、黄柏15～30份、熟地黄10～20份、黄岑10～15份、山萸肉10～30份、枸杞20～40份、白芷10～30份、洋甘菊10～30份、黄精10～20份、旱莲草10～25份、维生素E～3～10份、精油5～15份、乳化剂5～25份和辅助乳化剂1～20份。（18）[申请号] CN201710559828.4一种针对阴虚体质人群失眠的中药组方，其原料按重量份计为：石菖蒲8～12份、响铃草30～40份、麦冬8～12份。（19）[申请号] CN201710437080.0一种调理阴虚体质的养生固体饮料及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、百合15～20﹪、低聚果糖23～33﹪、玉竹3～5﹪、酸枣仁3～5﹪、鲜芦根3～5﹪、甘草10～15﹪、砂仁1～2﹪、枸杞子3～5﹪、麦芽糊精3～5﹪，经混合、干燥、粉碎、整粒、杀菌、装袋获得产品。（20）[申请号] CN201610907293.0一种阴虚体质的茶饮，它涉及养生茶饮技术领域。它包含以下质量分数原料：葛根25％～30％、百合10％～15％、玉竹25％～30％、橘皮15％～20％、配方料5％～25％，其中所述的配方料中包含枸杞子、栀子、酸枣仁、桑椹、莲子、山药、人参和黄精；所述的配方料中各种原料占配方料的总质量的质量分数为：枸杞子25％～30％、栀子10％～20％、酸枣仁20％～30％、桑椹8％～15％、莲子5％～10％、山药5％～15％、人参5％～12％和黄精5％～10％。（21）[申请号] CN201611017103.4一种女人阴虚体质的汤补药，由下述重量份的原料制得：银耳2～8份、百合2～4份、玉竹2～4份、枸杞3～5份、罗汉果1～3份、莲藕3～5份、猪腱5～10份、冰糖1～3份、瑶柱2～4份、虾3～5份。（22）[申请号] CN201710136006.5一种改善人体阴虚体质达到平和体质类型的药酒及其配方，包括纯粮白酒和药材；所述药材包括鹿尾巴、龟甲、林下山参、西洋参、石斛、北沙参、太子参、黄精、熟地、桑葚、女贞子、牛膝、甘草、五味子、菟丝子、山茱萸、玉竹、麦冬、枸杞、灵芝、葛根、党参、杜仲。（23）[申请号] CN201710015428.7一种用于调节阴虚体质的中药糕点配方。糕点配方由如下重量份数原料组成：熟地黄9～15份、山茱萸6～12份、山药5～30份、茯苓10～15份、枸杞子5～15份、当归6～12份、橘皮3～10份、黄芪9～30份、龙眼肉6～15份、酸枣仁(炒)5～15份、生姜3～10份、大枣6～15份、甘草(炙)1～10份。（24）[申请号] CN201510814208.1一种专门用于中老年气虚阴虚体质调理代茶饮的配方，由红小豆，红枣，红衣花生，枸杞子，龙眼，红糖组成。（25）[申请号]CN201510849464.4一种专门用于气虚阴虚体质代茶饮的配方及其制备方法，由灵芝，黄芪，女贞子，枸杞子，红茶组成。（26）[申请号] CN201710437080.0一种调理阴虚体质的养生固体饮料及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、百合15～20﹪、低聚果糖23～33﹪、玉竹3～5﹪、酸枣仁3～5﹪、鲜芦根3～5﹪、甘草10～15﹪、砂仁1～2﹪、枸杞子3～5﹪、麦芽糊精3～5﹪，经混合、干燥、粉碎、整粒、杀菌、装袋获得产品。（27）[申请号] CN201710445301.9一种调理阴虚体质的膏滋方便食品及其制备方法，按原料的重量百分比组成：蜂蜜40g、人参(人工种植)3g、牡蛎8g、蛹虫草3g、酸枣仁3g、黄精3g、甘草10g、阿胶8g、枸杞子3g，经混合、搅拌、蒸煮、过滤、灌装、杀菌获得产品。（28）[申请号]CN201710431371.9一种调理阴虚体质的健康茶饮品及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、百合15～20﹪、桑叶30～38﹪、玉竹3～5﹪、酸枣仁3～5﹪、鲜芦根3～5﹪、砂仁1～2﹪、甘草10～15﹪、枸杞子3～5﹪，经混合、干燥、粉碎、过筛、杀菌、装袋获得产品。（29）[申请号] CN201710559828.4一种针对阴虚体质人群失眠的中药组方，其原料按重量份计为：石菖蒲8～12份、响铃草30～40份、麦冬8～12份。（30）[申请号]CN201710697830.8针对阴虚体质按摩中药油乳，涉及中药油乳技术领域，其组分按重量份包括：沙参10～30份、五倍子20～40份、天冬门20～30份、丹皮20～40份、玉竹15～30份、石斛10～20份、百合15～40份、黄柏15～30份、熟地黄10～20份、黄岑10～15份、山萸肉10～30份、枸杞20～40份、白芷10～30份、洋甘菊10～30份、黄精10～20份、旱莲草10～25份、维生素E3～10份、精油5～15份、乳化剂5～25份和辅助乳化剂1～20份。（31）[申请号]CN201410398942.X一种用于调理气虚阴虚体质凉茶的配方，由灵芝，黄芪，女贞子，枸杞子，菊花，槡椹，五味子，桂园，山楂组成。（32）[申请号] CN201510910273.4一种用于阴虚体质的药食配方，是由如下重量份数的原料组成的：黄精5-15份、山药5-30份、玉竹5-15份、百合5-15份、枸杞子5-15份、酸枣仁(炒)5-15份、覆盆子5-15份、芦根5-30份、甘草(炙)1-10份。（33）[申请号] CN201610171750.4本发明提供了调节阴虚体质的食品组合物及其制备方法。食品组合物包括以下原料：银耳、黑豆、糯米、黑米、黑芝麻、小麦仁、桑葚、莲藕、蜂蜜、花生、苦瓜、燕窝、阿胶、黄精、百合、火麻仁、马齿笕、玉竹、大米和麦芽糊精。（34）[申请号]CN201610206794.6一种针对阴虚体质的保健品及其制备方法；本发明包括按照干重重量份计算的如下材料：石斛15～25份、西洋参5～15份、北沙参5～15份、石金钱龟板5～25份和鳖甲10～20份。（35）[申请号] CN201610216651.3一种调理阴虚体质的调理餐，由下列质量份数的原料制成：黑豆10～15份、玉竹8～12份、百合10～15份、山药10～15份、绿豆10～15份、枸杞子10～15份、松子10～15份、黄豆10～15份、荸荠10～15份、佛手3～7份、荷叶3～7份、芡实3～7份、冰糖10～15份。（36）[申请号]CN201610267102.9一种适合阴虚体质者饮用的白茶，由下列物质制成：茶鲜叶、荷叶、冬瓜皮、绿豆、麦冬、泽泻、牡丹皮、铁皮枫斗、淮山、龟甲、黑芝麻。（37）[申请号]CN201410538287.3一种改善阴虚体质的食品及其制备工艺。本发明改善阴虚体质的食品，通过合理配伍，可使个别药味的功效产生协同作用，具有改善阴虚体质的手足心热，平素易口燥咽干，鼻微干，口渴喜冷饮，面色潮红，有烘热感，两目干涩，视物模糊，唇红微干，皮肤偏干，易生皱纹，眩晕耳鸣，睡眠差，小便短等症状作用。（38）[申请号]CN201310427610.5一种专门用于气虚阴虚体质保健药茶的配方，由灵芝，黄芪，女贞子，枸杞子，红茶组成。（39）[申请号] CN201310426212.1一种用于调理气虚阴虚体质代茶饮的配方，由灵芝，黄芪，女贞子，枸杞子组成。（40）[申请号]CN201410795006.2一种调节阴虚体质的泡脚粉，包括如下重量份数的组份：熟地黄10～20份、白芷5～10份、吴茱萸10～20份、苦参5～10份、黄芪5～10份、菟丝子5～10份、甘草20～30份、黄精4.8～8.2份、合欢皮5～10份，当归5～10份。（41）[申请号]CN201510208360.5一种用于阴虚体质的阿萨伊果保健品，包括以下质量份数的原料：阿萨伊果1-6份、蛋白核小球藻1-8份、枇杷叶1-8份、枸杞子1-9份、百合1-10份、玉竹1-10份、黄精1-12份、佛手1-5份、莲子1-6份、酸枣仁1-9份、覆盆子1-5份、余甘子1-5份、桑椹1-10份、蜂蜜1-6份、蛹虫草0.5-5份、桑叶1-5份、益智仁1-6份、葛根1-6份、辣木叶1-7份、平卧菊三七1-5份；还可以包括木瓜1-9份。（42）[申请号]CN201410087054.6一种调理阴虚体质酵素及其制备方法；该种调理阴虚体质酵素的成分为：九品莲花叶10%、薰衣草花10%、苦瓜20%、百合5%、山药20%、绿豆苗10%、薏米20%、黑芝麻5%；经由益生菌群经三级发酵而成，其制备方法如下(A)黑芝麻与薏米炒熟，其他材料粉碎成40目碎末状，(B)益生菌群：由昆仑根霉、红曲霉、蜂蜜酵母，肋状拟内孢霉、双岐青春杆菌，细黄链霉菌组成，(C)将(A)所述的材料进行醇化发酵后，再以1:1的比率与糙米醋进行二次发酵后再投入双岐青春杆菌与细黄链霉菌进行酯化发酵、发酵期间为90天，发酵完成后所得悬液即为调理阴虚体质酵素。（43）[申请号]CN201410075053.X一种治疗阴虚体质足浴中药及其制备方法，由以下原料制成：白芍、旱莲草、丝瓜络、黄精、白木耳、粗黄草、淡秋石、角盘兰、蜢臂兰、菩提香、石莲、萱草根、知母和玉竹；所述原料由以下重量份数配比组成：白芍30g、旱莲草15g、丝瓜络6g、黄精15g、白木耳5g、粗黄草5g、淡秋石8g、角盘兰6g、蜢臂兰4g、菩提香12g、石莲8g、萱草根6g、知母4g和玉竹4g。（44）[申请号] CN201410182009.9一种阴虚体质保健食品及其制备方法，该保健食品以药食同源原料黄精、桑椹、玉竹、莲子、杭白菊和山药为有效药物组分以及在药品和食品中允许使用的辅助添加成分组成，以重量份计的各有效药食两用组分的生药原料组成为：黄精100～300份、桑椹22.5～90份、玉竹17.5～70份、莲子16～120份、杭白菊20～60份和山药18～72份。（45）[申请号]CN201410243709.4一种调理阴虚体质茶，其特征在于包括以重量计的下列组分：葛根900g～1100g、决明子900g～1100g、山药900g～1100g、黄精900g～1100g、百合900g～1100g、玉竹～900g～1100g、枸杞900g～1100g、桑葚900g～1100g、胶原蛋白900g～1100g、桑叶900g～1100g、乌梅900g～1100g、阿胶900g～1100g、玛咖800g～1000g、蚕蛹800g～1000g、菊花800g～1000g、淡竹叶700g～900g、银金花800g～1000g、茯苓粉800g～1000g、人参700g～900g。（46）[申请号]CN201310119273.3一种调节阴虚体质的泡脚粉及其制备方法，该泡脚粉是由以下重量份的原料制：广木香1～180份、山楂1～90份、白术1～150份、白芍1～150份、黄芪1～100份、黄精1～150份、鸡血藤1～150份、何首乌1～150份、女贞子1～130份、旱莲草1～130份、夜交藤1～150份、牛膝1～130份。（47）[申请号]CN201210290237.9一种治疗阴虚体质的组合物，其特征在于包括以下重量份的原料：桑叶4～9份、菊花6～12份、甘草6～12份、黑芝麻1～5份、枸杞子1～5份，阿胶4～9份。（48）[申请号]CN201110099938.X一种用于阴虚体质人缓解精血亏虚中药制剂及其制备方法和应用，该中药制剂的药效成分包括以下质量份数的原料药：黄精30-60、益智仁50-110、山药45-90、枸杞子50-100、桑葚50-110、黑芝麻20-40、花椒50-110、桃仁25-50、酸枣仁30-70、栀子40-80、淡豆豉20-50、小麦30-60、大枣40-90、甘草40-90、代代花20-50、黄花菜30-60。（49）[申请号]CN201110099922.9一种用于阴虚体质人缓解津液不足症状的中药制剂及其制备方法和应用，该中药制剂的药效成分包括以下质量份数的原料药：玉竹40-70、郁李仁80-110、百合60-150、甘草60-190、黄精20-60、山药90-160、枸杞子80-170、决明子20-60、桑葚30-70、桑叶40-60、菊花30-60、桃仁50-80、黑芝麻40-70、佛手30-70、桔梗40-80。（50）[申请号]CN200410029559.3一种阴虚体质保健饮料，其特征在于是由下述重量百分比的原料制备而成的：洋梨70％～99％，枸杞1％～30％，制备时洋梨经常规预处理，剔出不合格果，去皮切半，挖去籽巢，修去梗、蒂、斑点、机械伤等，浸于1％食盐溶液中短时间护色，在果肉中加入1～6倍水，加热微沸8～10分钟，果实软化后用孔径0.5～0.7毫米打浆机打两次，加热到50～90℃，榨汁，过滤，滤液冷却备用；枸杞经常规预处理，分切，搅 汁打浆，加水调温，加纤维素酶搅拌浸提后过滤得到枸杞提取液，与上述滤液混合，调温，加入果胶酶，搅匀，静置，过滤，滤液加入适量的砂糖及柠檬酸，过滤，杀菌，灌装，冷却即得。
本发明与以上现有阴虚体质50项申请（专利）比较，不同之处在于：处方组成明显不同。本发明技术原创性在于中医辨证与西医辨病相结合，组方上结合现代研究，阴虚体质多伴有体内代谢功能低下、对氧化物的清除力下降、脂质过氧化程度增强等的关键问题，采用滋补阴血、生津润燥与调节机体代谢、抗氧化相结合，形成原创的创新保健产品。通过以上主权项比较，可以看出本发明与以上现有阴虚体质申请（专利）比，在主权项处方组成上与本发明无实质等同，说明以上申请（专利）对本发明的新颖性和创造性不构成实质性影响。
发明内容
本发明的目的在于提供一种阴虚体质保健固体饮料及其制备方法，适用于阴虚体质人群，以及有阴虚体质症状的人群服用，症见形体消瘦，两颧潮红，手足心热，潮热盗汗，心烦易怒，口干，头发、皮肤干枯，舌干红、少苔，甚至光滑无苔。
本发明的技术方案：一种阴虚体质保健固体饮料，由黑桑椹、黄精、黑果枸杞、黑果腺肋花揪、VB1制成，其特征在于是由下述原料成份和重量配比制备而成：黑桑椹400～1500份、黄精400～1500份、黑果枸杞100～500份、黑果腺肋花揪60～250份、VB1 0.011～0.11份；本发明优选重量配比范围是：黑桑椹500～1200份、黄精500～1200份、黑果枸杞150～400份、黑果腺肋花揪80～200份、VB1 0.033～0.09份；本发明最佳重量配比范围是：黑桑椹750份、黄精750份、黑果枸杞250份、黑果腺肋花揪125份、VB10.055份。
一种阴虚体质保健固体饮料的制备方法，其特征在于颗粒剂的制备辅料加入乳糖500～2000份、麦芽糊精200～900份、异麦芽酮糖醇1000～4000份、羧甲基纤维素钠200～1000份、罗汉果甜苷20～80份、蓝莓速溶粉50～200份。
一种阴虚体质保健固体饮料的制备方法，其特征在于采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。其颗粒剂制备方法按以下步骤：
1、配料称量、粉碎过筛：按配料单称取黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）；另取异麦芽酮糖醇粉碎过80目筛，备用；
2、煎煮：黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）加10倍量水煎煮2次，每次1.5小时，200目过滤，合并滤液，备用；
3、滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.08～1.10（60℃测）的浸膏，离心，离心液继续减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.12～1.20（60℃测）的浸膏，加入配方量的乳糖、麦芽糊精搅拌均匀，减压干燥（-0.08～-0.10MPa，50～70℃）至干，备用；
4、粉碎过筛：备用的含辅料干浸膏粉碎过80目，得干浸膏粉，备用；
5、混合、制粒：按配方量称取异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉一起置高效湿法制粒机中搅拌混合均匀，用90%乙醇（用量约为配方重量9%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，55℃干燥至干燥至水分≤5%，14目整粒，得干颗粒，备用；
6、总混：将VB1、蓝莓速溶粉与备用部分干颗粒等量递增混合后，再与剩余干颗粒一起置于三维总混机中混合30min，得总混物，备用；
7、内包装：将备用总混物装袋，5g/袋；
8、外包装：贴标签，装盒，装箱，待检验合格后入库；
9、检验入库：成品经检验合格后，入库。
本发明技术原创性在于中医辨证与西医辨病相结合，组方上结合现代研究，阴虚体质多伴有体内代谢功能低下、对氧化物的清除力下降、脂质过氧化程度增强等的关键问题，采用滋补阴血、生津润燥与调节机体代谢、抗氧化相结合，形成原创的创新保健产品。其优点在于组方独特，疗效确切、安全、经济、无明显毒副作用，适用于阴虚体质人群，以及有阴虚体质症状的人群服用，症见形体消瘦，两颧潮红，手足心热，潮热盗汗，心烦易怒，口干，头发、皮肤干枯，舌干红、少苔，甚至光滑无苔。
本发明颗粒剂（由黑桑椹、黄精、黑果枸杞、黑果腺肋花揪、VB1制成）对有形体消瘦，两颧潮红，手足心热，潮热盗汗，心烦易怒，口干，头发、皮肤干枯等阴虚体质症状的人群试用（每次1袋，每天2次，连服2周）。疗效判定：自觉症状改善≥50%，为显效；<50%，为有效；无变化，为无效。结果表明，35例自愿受试者，显效24例，有效9例，无效2例；总有效率94.29%。服用期间未出现不良反应。
四、具体实施方式
下面以具体实施例对本发明作详细说明：
实施例1：
按照下列配比称取原料和辅料：黑桑椹400份、黄精400份、黑果枸杞100份、黑果腺肋花揪60份、VB1 0.011份；乳糖500份、麦芽糊精200份、异麦芽酮糖醇1000份、羧甲基纤维素钠200份、罗汉果甜苷20份、蓝莓速溶粉50份。
制备方法：（1）配料称量、粉碎过筛：按配料单称取黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）；另取异麦芽酮糖醇粉碎过80目筛，备用；（2）煎煮：黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）加10倍量水煎煮2次，每次1.5小时，200目过滤，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.08～1.10（60℃测）的浸膏，离心，离心液继续减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.12～1.20（60℃测）的浸膏，加入配方量的乳糖、麦芽糊精搅拌均匀，减压干燥（-0.08～-0.10MPa，50～70℃）至干，备用；（4）粉碎过筛：备用的含辅料干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：按配方量称取异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉一起置高效湿法制粒机中搅拌混合均匀，用90%乙醇（用量约为配方重量9%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，55℃干燥至干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将VB1、蓝莓速溶粉与备用部分干颗粒等量递增混合后，再与剩余干颗粒一起置于三维总混机中混合30min，得总混物，备用；（7）内包装：将备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例2：
按照下列配比称取原料和辅料：黑桑椹1500份、黄精1500份、黑果枸杞500份、黑果腺肋花揪250份、VB1 0.11份；乳糖2000份、麦芽糊精900份、异麦芽酮糖醇4000份、羧甲基纤维素钠1000份、罗汉果甜苷80份、蓝莓速溶粉200份。
制备方法：（1）配料称量、粉碎过筛：按配料单称取黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）；另取异麦芽酮糖醇粉碎过80目筛，备用；（2）煎煮：黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）加10倍量水煎煮2次，每次1.5小时，200目过滤，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.08～1.10（60℃测）的浸膏，离心，离心液继续减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.12～1.20（60℃测）的浸膏，加入配方量的乳糖、麦芽糊精搅拌均匀，减压干燥（-0.08～-0.10MPa，50～70℃）至干，备用；（4）粉碎过筛：备用的含辅料干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：按配方量称取异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉一起置高效湿法制粒机中搅拌混合均匀，用90%乙醇（用量约为配方重量9%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，55℃干燥至干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将VB1、蓝莓速溶粉与备用部分干颗粒等量递增混合后，再与剩余干颗粒一起置于三维总混机中混合30min，得总混物，备用；（7）内包装：将备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例3：
按照下列配比称取原料和辅料：黑桑椹750份、黄精750份、黑果枸杞250份、黑果腺肋花揪125份、VB10.055份；乳糖1000份、麦芽糊精450份、异麦芽酮糖醇1860份、羧甲基纤维素钠500份、罗汉果甜苷40份、蓝莓速溶粉100份。
制备方法： （1）配料称量、粉碎过筛：按配料单称取黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）；另取异麦芽酮糖醇粉碎过80目筛，备用；（2）煎煮：黑桑椹、黄精、黑果枸杞、黑果腺肋花揪（干）加10倍量水煎煮2次，每次1.5小时，200目过滤，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.08～1.10（60℃测）的浸膏，离心，离心液继续减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.12～1.20（60℃测）的浸膏，加入配方量的乳糖、麦芽糊精搅拌均匀，减压干燥（-0.08～-0.10MPa，50～70℃）至干，备用；（4）粉碎过筛：备用的含辅料干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：按配方量称取异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉一起置高效湿法制粒机中搅拌混合均匀，用90%乙醇（用量约为配方重量9%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，55℃干燥至干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将VB1、蓝莓速溶粉与备用部分干颗粒等量递增混合后，再与剩余干颗粒一起置于三维总混机中混合30min，得总混物，备用；（7）内包装：将备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
Claims (7)
1.一种阴虚体质保健固体饮料，其特征在于是由下述原料重量配比制备而成的制剂：黑桑椹400～1500份、黄精400～1500份、黑果枸杞100～500份、黑果腺肋花揪60～250份、VB1 0.011～0.11份。
2. 如权利要求1所述的一种阴虚体质保健固体饮料，其原料的重量配比是：黑桑椹500～1200份、黄精500～1200份、黑果枸杞150～400份、黑果腺肋花揪80～200份、VB1 0.033～0.09份。
3.如权利要求1～2之一所述的一种阴虚体质保健固体饮料，其原料的重量配比是：黑桑椹750份、黄精750份、黑果枸杞250份、黑果腺肋花揪125份、VB10.055份。
4.如权利要求1～3之一所述的一种阴虚体质保健固体饮料，其特征在于制备方法是采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。
5.如权利要求4所述的一种阴虚体质保健固体饮料的制备方法，其特征在于颗粒剂的制备方法是按上述原料组合配比，通过以下步骤制备：（1）配料称量、粉碎过筛：按配料单称取黑桑椹、黄精、黑果枸杞、干黑果腺肋花揪；另取异麦芽酮糖醇粉碎过80目筛，备用；（2）煎煮：黑桑椹、黄精、黑果枸杞、干黑果腺肋花揪加10倍量水煎煮2次，每次1.5小时，200目过滤，合并滤液，备用；（3）滤液浓缩干燥：滤液经-0.06～-0.08MPa，50～70℃减压浓缩至相对密度60℃时测1.08～1.10的浸膏，离心，离心液继续-0.06～-0.08MPa，50～70℃减压浓缩至相对密度为60℃时测1.12～1.20的浸膏，加入配方量的乳糖、麦芽糊精搅拌均匀，-0.08～-0.10MPa，50～70℃减压干燥至干，备用；（4）粉碎过筛：备用的含辅料干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：按配方量称取异麦芽酮糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉一起置高效湿法制粒机中搅拌混合均匀，用90%乙醇用量约为配方重量9%作为润湿剂制软材，16目制粒，55℃干燥至干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将VB1、蓝莓速溶粉与备用部分干颗粒等量递增混合后，再与剩余干颗粒一起置于三维总混机中混合30min，得总混物，备用；（7）内包装：将备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
6.如权利要求5所述的一种阴虚体质保健固体饮料颗粒剂的制备方法，其特征在于颗粒剂辅料加入乳糖500～2000份、麦芽糊精200～900份、异麦芽酮糖醇1000～4000份、羧甲基纤维素钠200～1000份、罗汉果甜苷20～80份、蓝莓速溶粉50～200份。
7.如权利要求1～3之一所述的固体饮料在制备用于阴虚体质保健药物的应用。
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