CN112914008A - 一种气郁体质保健固体饮料及其制备方法 - Google Patents
一种气郁体质保健固体饮料及其制备方法 Download PDFInfo
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
本发明涉及一种气郁体质保健固体饮料。它是由佛手、香橼、重瓣红玫瑰、r‑氨基丁酸，加辅料麦芽糊精、D‑甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉制成，采用药学上可接受的载体或赋形剂制成的药剂，包括颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂等。具有疏肝解郁、理气和中、调节机体神经内分泌之功效，适用于气郁体质人群，以及有气郁体质症状的人群服用，症见性格多孤僻内向，易多愁善感，气量较狭小。临床使用表明本发明可改善气郁体质的症状，未见不良反应。
Description
技术领域
本发明涉及一种气郁体质保健固体饮料及其制备方法。
背景技术
气郁体质（Qi depression constitution）是由于长期情志不畅、气机郁滞而形成的以性格内向不稳定、忧郁脆弱、敏感多疑为主要表现的体质状态。处于这种体质状态者，多见于中青年，以女性多见，性格多孤僻内向，易多愁善感，气量较狭小。
中医药在治疗气郁体质方面积累了丰富经验，疗效确切，亟待研究开发。中医认为：气郁体质者的发病以肝为主，兼及心、胃、大肠、小肠。易伤情志及饮食，易产生气机不畅，如郁病、失眠、梅核气、惊恐等。由于气郁在先、郁滞为本，在治疗方面，多从调畅情志，疏通气机入手，多以汤剂为主，使用不便。
本发明针对气郁体质选用君药：佛手舒肝理气。臣药：香橼疏肝解郁、理气和中；玫瑰花芳香行气、有疏肝解郁、醒脾和胃、活血散瘀之功，共助佛手疏肝解郁；佐使药：结合现代研究气郁证患者多有神经内分泌紊乱。r-氨基丁酸（γ-aminobutyric acid，简称GABA）调节体内神经内分泌紊乱。研究表明，GABA不仅具有降低神经元活性、防止神经细胞过热以及降低血压的作用，还具有防止动脉硬化、调节心律失常、降低血脂、增强肝功能等生理功效。为此，加入r-氨基丁酸调节体内神经内分泌紊乱，促使脑部血流顺畅、调节心律失常、降低血脂、增强肝功能、对血压、脾脏、胃等器官都有良好的保护和营养改善作用。此外，为保证产品的剂型和口感，加入国际食品标准中允许加入的辅料，如麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉。
本发明与现有气郁体质专利技术比较如下。经检索中国知网专利库，涉及气郁体质专利申请共42项，其申请（专利）号、名称和组方如下：（1）[申请号] CN201810355671.8一种调理气郁体质的压片糖果和用途,它是由下列重量配比的原料制备而成：麦芽400～600份,香橼400～600份,花椒80～170份。（2）[申请号] CN201910535030.5一种气郁体质固体饮料及其制备方法,该固体饮料,由以下配方按照下列重量份配制而成：佛手6～10份,玫瑰花3～6份,麦芽10～15份,芦根15～30份,决明子9～15份,甘草2～10份,山楂2～5份,陈皮1～3份,冰糖1～2份。（3）[申请号] CN201810108106.1一种改善气郁体质的中药组合物、佛手薄荷膏及制备方法。该中药组合物的活性成分是由以下重量份原料制备而成：佛手0.7～4.5份,茯苓2.5～7.5份,龙眼肉0.5～1.2份,生姜0.7～2份,薄荷0.4～1.2份,麦芽0.7～2份。（4）[申请号] CN201810037310.9一种改善气郁体质的食品,其特征在于包含：基质粉和体质粉；其中所述基质粉包含糙米、大豆蛋白粉、大豆膳食纤维、薏米、燕麦、小麦胚芽,所述体质粉包含陈皮、佛手、紫苏、代代花、百合、玫瑰、甘草。（5）[申请号] CN201910097409.2一种调理气郁体质的中药泡浴抑菌液/颗粒及制备与使用方法,所述中药泡浴抑菌液/颗粒的原料包括如下重量份的组分：合欢花5-35份,首乌藤5-35份,香附5-35份,紫苏梗5-35份,栀子5-35份,银耳5-50份。（6）[申请号] CN201811305827.8一种改善气郁体质的功能食品及其制备方法,由以下重量份原料提取制备：佛手2-20份,香橼2-20份,紫苏1-15份,薄荷1-15份,代代花1-10份,重瓣红玫瑰1-10份。（7）[申请号] CN201811422134.7一种改善气郁体质的饼干生产方法,其特征在于以佛手、香橼、陈皮、木瓜、紫苏、玫瑰花、酸枣仁、百合、薄荷、代代花、枸杞子、酸枣仁、薤白、红枣、甘草为原料制成的中药提取物,加以小麦粉、麦芽粉、茯苓粉、小苏打、食盐放入搅拌机中,加35-43℃水进行面团调制,形成面团后进行面团发酵,发酵完成后放入饼干成形机压延成型,再放入烤炉进行烘烤,出炉冷却后包装为成品。（8）[申请号] CN201811400401.0一种改善气郁体质的养生茶饮,其特征是以佛手、香橼、陈皮、木瓜、紫苏、玫瑰花、麦芽、酸枣仁、百合、薄荷、代代花、枸杞子、酸枣仁、茯苓、薤白、红枣、甘草为原料,经水煮提取、干燥制得水煮提取物,加入甜叶菊粉,然后经混合、制粒、包装步骤制成。（9）[申请号] CN201811079033.4一种调理气郁体质的宣木瓜膏剂及其制备方法,它所含的活性成分由下列重量份原料配比制备而成：宣木瓜15-35份、茯苓15-25份、山楂15-20份、甘草10-20份、紫苏10-15份、佛手8-12份、栀子8-10份、陈皮5-8份、蛹虫草5-7份、人参(人工种植)3-5份、蜂蜜10-20份,经混合、搅拌、煎煮、过滤、静置、煎煮、过滤、冷却、灌装、杀菌获得产品。（10）[申请号] CN201810498086.3一种针对气郁体质人群的保健茶的制备方法,其特征在于,包括以下步骤：(1)将原料合欢皮、青皮、明党参、茉莉花、梅花洗净除杂,备用；(2)分别取洗净除杂后的原料进行真空冷冻干燥,然后粉碎成颗粒；(3)将步骤(2)所得的颗粒和超微和田玉粉充分混合均匀,灭菌,包装即得。（11）[申请号]CN201810058901.4一种改善气郁体质的营养套餐,由胡陈炒肉丝、金佛山药、百黄汤、百合什锦饭和梅橘茶组成。（12）[申请号] CN201711240352.4一种用于调理气郁体质的固体饮料。该固体饮料包括以下重量份数的原料组分：20～44份的香橼、17～45份的紫苏、10～38份的佛手、9～35份的代代花、10～33份的刀豆、20～50份的薄荷、18～50份的酸枣仁、24～43份的麦芽、11～32份的橘皮、17～45份的青果、8～23份的胖大海、25～55份的糊精、15～45份的麦芽糊精、15～45份的可溶性淀粉和0.1～0.3份的阿斯巴甜。（13）[申请号]CN201611067538.X一种气郁体质食品配方,原料按照重量份数计算,比值分配包括：淡竹叶3～15份、桔皮5～30份、百合10～40份、佛手5～20份、玫瑰花5～25份、山楂10～50份、黄原胶0.5～2份。（14）[申请号] CN201711429362.2一种用于调理气郁体质的中药膏方。该中药膏方包括以下重量份数的原料组分：柴胡9～18份、白芍5～15份、生甘草2～11份、川芎2～10份、陈皮4～16份、枳壳5～16份、香附3～8份、薄荷5～15份、茯苓5～16份、苏叶4～14份、白术5～16份、草寇仁12～28份、木香5～15份、金铃子5～16份、荔枝核6～18份、佛手5～14份、香橼5～16份、玫瑰花6～16份、代代花3～10份、合欢皮4～15份、甘松5～16份、石菖蒲4～9份、太子参8～22份、山药5～15份、白扁豆5～15份、石斛4～17份、郁金6～18份、阿胶10～30份、鳖甲胶5～15份、龟板胶5～15份、木糖醇20～40份。（15）[申请号]CN201711165634.2一种改善气郁体质的药物或保健食品组合物,它是由包含下述重量配比的原料药制备而成：玳玳花8～12份、荜茇8～12份、丁香4～6份、佛手16～24份、陈皮16～24份、高良姜16～24份。（16）[申请号] CN201710697827.6一种针对气郁体质按摩中药油乳,其组分按重量份包括：离根香7～12份、云实根7～15份、延胡索4～12份、佛手2～8份、柑橘2～8份、萝卜2～8份、山楂2～8份、玫瑰花1～5份、陈皮1～8份、木香2～9份、香橼3～12份、麦芽5～15份、柏子仁5～12份、地鳖5～15份、麝香5～15份、六方藤6～19份、蟾酥6～12份、苦碟子5～15份、路路通9～18份、伸筋草5～15份、补骨脂5～15份。（17）[申请号]CN201710437228.0一种调理气郁体质的膏滋方便食品及其制备方法,按原料的重量百分比组成：蜂蜜15～25﹪、茯苓8～10﹪、蛹虫草3～5﹪、百合8～10﹪、紫苏8～10﹪、佛手3～5﹪、栀子3～5﹪、薄荷3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪,经混合、搅拌、蒸煮、过滤、灌装、杀菌获得产品。（18）[申请号] CN201710416094.4一种调理气郁体质的健康茶饮品及其制备方法,按原料的重量百分比组成：桑叶8～10﹪、茯苓8～10﹪、麦芽15～20﹪、百合8～10﹪、紫苏8～10﹪、佛手3～5﹪、栀子3～5﹪、薄荷3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪,经混合、干燥、粉碎、过筛、杀菌、装袋获得产品。（19）[申请号] CN201710435297.8一种调理气郁体质的养生固体饮料及其制备方法,按原料的重量百分比组成：麦芽10～20﹪、百合8～10﹪、茯苓8～10﹪、低聚果糖3～5﹪、紫苏8～10﹪、佛手3～5﹪、薄荷3～5﹪、栀子3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪、麦芽糊精3～5﹪,经混合、干燥、粉碎、整粒、杀菌、装袋获得产品。（20）[申请号]CN201710134703.7一种改善气郁体质类型达到平和体质类型的药酒及其配方,包括纯粮白酒和药材；所述药材包括白参、郁金、香附、陈皮、麦冬、熟地、白芍、丹参、玫瑰、百合、灵芝、枸杞、党参、苍术、玉竹。（21）[申请号] CN201710134703.7一种改善气郁体质类型达到平和体质类型的药酒及其配方,包括纯粮白酒和药材；所述药材包括白参、郁金、香附、陈皮、麦冬、熟地、白芍、丹参、玫瑰、百合、灵芝、枸杞、党参、苍术、玉竹。（22）[申请号]CN201710416094.4一种调理气郁体质的健康茶饮品及其制备方法,按原料的重量百分比组成：桑叶8～10﹪、茯苓8～10﹪、麦芽15～20﹪、百合8～10﹪、紫苏8～10﹪、佛手3～5﹪、栀子3～5﹪、薄荷3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪,经混合、干燥、粉碎、过筛、杀菌、装袋获得产品。（23）[申请号] CN201710435297.8一种调理气郁体质的养生固体饮料及其制备方法,按原料的重量百分比组成：麦芽10～20﹪、百合8～10﹪、茯苓8～10﹪、低聚果糖3～5﹪、紫苏8～10﹪、佛手3～5﹪、薄荷3～5﹪、栀子3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪、麦芽糊精3～5﹪,经混合、干燥、粉碎、整粒、杀菌、装袋获得产品。（24）[申请号] CN201710437228.0一种调理气郁体质的膏滋方便食品及其制备方法,按原料的重量百分比组成：蜂蜜15～25﹪、茯苓8～10﹪、蛹虫草3～5﹪、百合8～10﹪、紫苏8～10﹪、佛手3～5﹪、栀子3～5﹪、薄荷3～5﹪、橘皮8～10﹪、甘草8～10﹪、人参(人工种植)3～5﹪,经混合、搅拌、蒸煮、过滤、灌装、杀菌获得产品。（25）[申请号]CN201710697827.6一种针对气郁体质按摩中药油乳,其组分按重量份包括：离根香7～12份、云实根7～15份、延胡索4～12份、佛手2～8份、柑橘2～8份、萝卜2～8份、山楂2～8份、玫瑰花1～5份、陈皮1～8份、木香2～9份、香橼3～12份、麦芽5～15份、柏子仁5～12份、地鳖5～15份、麝香5～15份、六方藤6～19份、蟾酥6～12份、苦碟子5～15份、路路通9～18份、伸筋草5～15份、补骨脂5～15份。（26）[申请号] CN201510652531.3一种用于气郁体质调理的药膳及其制备方法,其组份包括：大枣、炙黄芪、人参、白术、苍术、茯苓、炒麦芽、柴胡、桂枝、香附、郁金、佛手、香橼、薄荷、合欢皮、玫瑰花、炙甘草、丹参、白芍、当归、川芎、百合、桔梗、木香、枳实、砂仁、延胡索、枸杞子、杜仲、覆盆子、炒薏苡仁、牛膝、栀子、淡豆豉、竹茹、泽兰、生姜、小茴香、火麻仁、赤砂糖和淀粉糖浆。（27）[申请号] CN201610018387.2一种用于气郁体质的药食配方,是由如下重量份数的原料组成的：香橼3-10份、佛手3-10份、紫苏3-10份、玫瑰花2-6份、麦芽10-15份、酸枣仁(炒)10-15份、百合6-12份、大枣6-15份、甘草(生)2-10份。（28）[申请号] CN201610297946.8一种调理气郁体质的调理餐,由下列质量份数的原料制成：黑芝麻15～20份、阿胶5～10份、小麦10～15份、人参5～10份、酸枣仁5～10份、香橼3～5份、莲子10～15份、佛手10～15份、花生15～20份、百合5～10份、大枣7～10份、冰糖12～15份。（29）[申请号] CN201610171742.X调节气郁体质的食品组合物及其制备方法。食品组合物包括以下原料：黄豆、萝卜籽、荞麦、高粱米、膳食纤维、苦瓜、山药、山楂、沙棘、佛手、百合、益智仁、小麦胚芽、大米和麦芽糊精。将除麦芽糊精外的其他原料加热制熟并混匀得到糊状物,将糊状物利用低温喷雾干燥机制备得到颗粒粉末,再加入麦芽糊精,即得。（30）[申请号] CN201410538274.6一种食品,具体的说是一种改善气郁体质的食品及其制备工艺。本发明改善气郁体质的食品,通过合理配伍,可使各药味的功效产生协同作用,具有改善气郁体质的失眠、情志不舒、健忘、胸胁胀满、善太息等症状作用。（31）[申请号]CN201410402552.5气郁体质全营养配方食品,其特征是以结合气郁体质者的体质特征,依据传统中医的精髓理论,因人而异,黄金配伍以1种以上药食两用的中药提取物精华、多种益生菌、短肽为主要原料,以益生元、碳水化合物、氨基酸、多种维生素、多种矿物质为辅料制成的食品；按下列原料及其用量进行配方：药食两用的提取物:炙黄芪14g、党参14g、当归14g、白术12g、麦冬12g、铁皮石斛12g、冬虫夏草(冬虫夏草菌丝体)11g、灵芝孢子粉(破壁)12g、蛹虫草11g、佛手11g、代代花11g、橘红9g、白扁豆花9g、百合6g、橘皮5g、玉竹5g、乌龙茶5g、玫瑰花5g、桑葚4g、淡竹叶4g、甘草4g、栀子4g、金橘2g、枸杞2g、扁豆2g、双歧杆菌100g、乳杆菌100g、嗜热链球菌50g、短肽200g、益生元100g、多种氨基酸100g、碳水化合物100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。（32）[申请号] CN201510192683.X气郁体质非全营养配方食品,其特征是结合气郁体质患者的体质特征,依据传统中医的精髓理论,因人而异,黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、益生元为主要原料,以一种、几种或全部的短肽、碳水化合物、氨基酸、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的全营养配方,或制成特定全营养配方食品和非全营养配方食品；按下列原料及其用量进行配方,药食两用的提取物及新资源食品:冬虫夏草(冬虫夏草菌丝体)13g、铁皮石斛12g、灵芝孢子粉(破壁)12g、炙黄芪11g、党参11g、当归10g、白术10g、蛹虫草9g、麦冬9g、佛手9g、代代花9g、橘红8g、白扁豆花8g、百合8g、橘皮8g、玉竹7g、乌龙茶7g、玫瑰花7g、桑葚7g、淡竹叶6g、甘草6g、栀子6g、金橘5g、扁豆5g、青钱柳叶3g、丹凤牡丹花3g、乌药叶3g、茶叶茶氨酸1g、乳矿物盐1g、短肽200g、益生元100g、多种氨基酸100g、碳水化合物100g、有保健功能的油酯100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。（33）[申请号] CN201510171492.5气郁体质医学配方食品,其特征是结合气郁体质患者的体质特征,依据传统中医的精髓理论,因人而异,黄金配伍以一种、几种或全部的药食两用中药提取物精华及新资源食品、多种益生菌、短肽为主要原料,以益生元、碳水化合物、氨基酸、有保健功能的油脂、多种维生素、多种矿物质为辅料制成的医学配方食品；按下列原料及其用量进行配方,药食两用的提取物及新资源食品：冬虫夏草(冬虫夏草菌丝体)13g、铁皮石斛12g、灵芝孢子粉(破壁)12g、炙黄芪11g、党参11g、当归10g、白术10g、蛹虫草9g、麦冬9g、佛手9g、代代花9g、橘红8g、白扁豆花8g、百合8g、橘皮8g、玉竹7g、乌龙茶7g、玫瑰花7g、桑葚7g、淡竹叶6g、甘草6g、栀子6g、金橘5g、扁豆5g、青钱柳叶3g、丹凤牡丹花3g、乌药叶3g、茶叶茶氨酸1g、乳矿物盐1g、多种益生菌300g、短肽200g、益生元100g、多种氨基酸100g、碳水化合物100g、有保健功能的油酯100g、维生素A0.01g、维生素D0.000015g、维生素E0.12g、维生素K0.0075g、维生素K10.00001g、维生素C10.625g、维生素B10.016g、维生素B20.016g、维生素B60.015g、维生素B0.0023g、维生素Be、维生素Bu、烟酸0.2g、叶酸0.003g、泛酸0.051g、胆碱2.5g、生物素0.000057g、钙6.2g、磷4.5g、钾10g、钠16.17g、镁1.7g、氯、铁0.15g、锌6.2g、硒0.00012g、铜0.007g、锰0.018g、碘0.00001g、氟0.00001g、铬0.00001g、钼0.00001g。（34）[申请号] CN201510563041.6一种调理气郁体质的保健品,包括以下质量份数的原料：玫瑰花1-10份、乌药叶1-6份、枸杞子1-8份、龙眼肉1-8份、红枣1-6份,或还添加砂仁1-4份、香橼1-4份、桔红1-4份、黄精1-4份、橘皮1-4份、佛手1-4份、百合1-4份、枳椇子1-4份、淡竹叶1-4份、酸枣仁1-6份、辣木叶1-6份、白芷1-4份、山楂1-4份、代代花1-4份、人参1-6份、白果1-4份、决明子1-4份、杜仲籽油1-4份、阿胶1-4份、白扁豆1-4份、乌龟1-4份、奇亚籽1-4份。（35）[申请号] CN201210309554.0一种气郁体质配餐或代餐品。各主要组分和制法和为：取橘皮、香橼、佛手、代代花、玫瑰花、紫苏叶、白扁豆花、甘草、金橘、菊花、荷叶煎汁加入白扁豆粉、荔枝核粉、山楂粉、百合粉、大枣粉、莲子粉、蛋白质粉、茯苓粉、茴香粉、桂圆肉粉、荞麦粉、海藻粉、海苔粉、海带粉、洋葱粉、糯米粉、萝卜粉、粳米粉、黄米粉、花生粉、大麦粉、小麦粉、高粱粉、黄花菜粉、刀豆粉、蘑菇粉、豆豉粉、苦瓜粉、山栀仁粉、槟榔粉、玉米粉、木瓜粉、牡蛎粉、海蜇粉、大蒜粉中,经高温熟化后,添加维生素B族粉、胶原蛋白粉、骨胶原蛋白粉、嗜酸乳杆菌粉、双岐杆菌粉、螺旋藻粉,混匀。（36）[申请号]CN201410129015.8一种气郁体质保健食品及其制备方法,该保健食品含有以下重量份计的生药成分：佛手15-100份、橘皮15-100份、紫苏10-80份、薄荷10-80份、玫瑰花10-80份、代代花10-80份。（37）[申请号] CN201310693121.4一种调理气郁体质的膳食,其特征在于包括以重量计的下列组分：微胶囊化后的双歧杆菌(青春双歧杆菌、乳双歧杆菌、两歧双歧杆菌、短双歧杆菌、婴儿双歧杆菌、长双歧杆菌)900g～1100g、乳杆菌(嗜酸乳杆菌粉、干酪乳杆菌、保加利亚乳杆菌、德氏乳杆菌、乳亚种格氏乳杆菌、发酵乳杆菌、瑞士乳杆菌、唾液乳杆菌、鼠李糖乳杆菌、罗伊氏乳杆菌、植物乳杆菌、副干酪乳杆菌、约氏乳杆菌)900g～1100g、嗜热链球菌900g～1100g、百合900g～1100g、淡竹叶900g～1100g、玉竹900g～1100g、代代花900g～1100g、玫瑰花900g～1100g、佛手900g～1100g、黄精900g～1100g、甘草900g～1100g、橘红900g～1100g、栀子900g～1100g、白扁豆花900g～1100g、乌龙茶900g～1100g、橘皮900g～1100g、白芷900g～1100g、桑葚900g～1100g、枸杞800g～1000g、芦根800g～1000g、金橘800g～1000g、扁豆700g～900g、茯苓700g～900g、枣500g～700g、磷脂酰丝氨酸500g～700g。（38）[申请号] CN201410103411.3一种调理气郁体质花茶酵素及其制备方法；其原料成分：茉莉花20%、熏衣草15%、石莲15%、甜叶菊10%、苦瓜20%、鼠尾草8%、薄荷7%、大蒜5%；益生菌由红酵母2%、禾本酵母2%、白地霉2%、毕次酵母1%、酒香酵母2%、双岐乳酸杆菌3%,乳酸链球菌2%组成的益生菌。（39）[申请号CN201410106462.1]一种治疗气郁体质的足浴中药,由以下重量份数配比组成：玫瑰花15g、八月扎15g、栀子15g、橘络15g、豹皮樟5g、波叶紫金牛5g、草香附5g、春砂花5g、刺玫花5g、佛手10g、甘松10g、锦葵10g、兰竹参5g、山佩兰5g、旱田草5g。（40）[申请号CN201210333578.X]一种治疗气郁体质的组合物,其特征在于包括以下重量份的原料：佛手3～7份、陈皮7～13份、木瓜4～9份、阿胶2～7份。（41）[申请号]CN201110099918.2一种用于气郁体质、痰湿体质人行气活血、软坚散结的中药制剂及其制备方法和应用,该中药制剂的药效成分包括以下质量份数的原料药：桃仁20-60、黄芥子30-50、昆布40-70、牡蛎20-70、蒲公英30-80、麦芽40-60、甘草30-70、鸡内金30-70、代代花10-40、橘红10-40、橘络20-60、橘核30-80、橘叶40-80、枸杞子30-70、芦笋50-80、灵芝20-70、蝮蛇40-70、佛手50-80。（42）[申请号] CN200410029561.0一种气郁体质保健饮料,其特征在于是由下述重量百分比的原料制备而成的： 金橘70％～99％,陈皮1％～30％,制备时金橘经常规预处理,剔除腐烂果和未成熟果, 清水洗果,剥皮,打浆机打浆,经孔径为0.4-0.8毫米的筛板筛滤,粗滤进入20目振动筛中,分离出果实碎片、种子等杂物,滤液通过均质机处理,在180～190公斤/厘米 2的压力下,使果汁中所含的粗大悬浮粒受压而破碎,并均匀而稳定分布于汁液中,加 热到50～90℃,过滤,滤液冷却到10℃以下,备用；陈皮经常规预处理,分切,搅汁打浆,加3～6倍量水调温至50～90℃,加纤维素酶搅拌浸提后过滤得到陈皮提取液, 与上述滤液混合,调温,加入果胶酶,搅匀,静置,过滤,滤液加入适量糖和柠檬酸,过滤,杀菌,灌装,冷却即得。
本发明与以上现有气郁体质42项申请（专利）比较，不同之处在于：处方组成明显不同。本发明技术原创性在于中医辨证与西医辨病相结合，组方上针对现代研究气郁证患者多有神经内分泌紊乱的关键问题，采用疏肝解郁、理气和中与调节机体神经内分泌紊乱相结合，形成原创的创新保健产品。通过以上主权项比较，可以看出本发明与以上现有气郁体质申请（专利）比，在主权项处方组成上与本发明无实质等同，说明以上申请（专利）对本发明的新颖性和创造性不构成实质性影响。
发明内容
本发明的目的在于提供一种气郁体质保健固体饮料及其制备方法，适用于气郁体质人群，以及有气郁体质症状的人群服用，症见性格多孤僻内向，易多愁善感，气量较狭小。
本发明的技术方案：一种气郁体质保健固体饮料，由佛手、香橼、重瓣红玫瑰、r-氨基丁酸制成，其特征在于是由下述原料成份和重量配比制备而成：佛手1500～6000份、香橼1000～4000份、重瓣红玫瑰500～2000份、r-氨基丁酸80～300份；本发明优选重量配比范围是：佛手2000～4000份、香橼1500～3000份、重瓣红玫瑰800～1500份、r-氨基丁酸100～200份；本发明最佳重量配比范围是：佛手3000份、香橼2000份、重瓣红玫瑰1000份、r-氨基丁酸150份。
一种气郁体质保健固体饮料的制备方法，其特征在于颗粒剂的制备辅料加入麦芽糊精1000～4000份、D-甘露糖醇50～300份、羧甲基纤维素钠100～500份、罗汉果甜苷5～30份、玫瑰冻干粉100～500份。
一种气郁体质保健固体饮料的制备方法，其特征在于采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。其颗粒剂制备方法按以下步骤：
1、前处理：麦芽糊精、D-甘露糖醇粉碎过80目筛，备用；按配方量称取佛手、香橼、r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉备用；
2、煎煮：佛手、香橼加水12倍煎煮1小时，过滤（200目），备用；
3、滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.05～1.15（60℃）的流浸膏（药材：药液约为1:1.5），离心,取上清液，上清液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.20～1.30（60℃）的流浸膏，减压干燥（-0.08～-0.10MPa，50～70℃）至干，得干浸膏备用；
4、粉碎过筛：备用干浸膏粉碎过80目，得干浸膏粉，备用；
5、混合、制粒：将r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉置高效湿法制粒机上搅拌混合均匀，用85%乙醇（用量约为配方重量8%）作为润湿剂制软材，16目制粒，60℃干燥至水分≤5%，14目整粒，得干颗粒，备用；
6、混合：将玫瑰冻干粉与上述备用干颗粒等量递增混匀至配方总量的5%后，加入上述剩余颗粒混合均匀，得总混物，备用；
7、内包装：备用总混物装袋，5g/袋；
8、外包装：贴标签，装盒，装箱，待检验合格后入库；
9、检验入库：成品经检验合格后，入库。
本发明技术原创性在于中医辨证与西医辨病相结合，组方上针对现代研究气郁体质患者多有神经内分泌紊乱的关键问题，采用疏肝解郁、理气和中与调节机体神经内分泌紊乱相结合，形成原创的创新保健产品。其优点在于组方独特，疗效确切、安全、经济、无明显毒副作用，适用于气郁体质人群，以及有气郁体质症状的人群服用，症见性格多孤僻内向，易多愁善感，气量较狭小。
本发明颗粒剂（由佛手、香橼、重瓣红玫瑰、r-氨基丁酸制成）对有性格多孤僻内向，易多愁善感，气量较狭小等气郁体质症状的人群试用（每次1袋，每天2次）。疗效判定：自觉症状改善≥50%，为显效；<50%，为有效；无变化，为无效。结果表明，28例自愿受试者，显效19例，有效7例，无效2例；总有效率92.86%。服用期间未出现不良反应。
四、具体实施方式
下面以具体实施例对本发明作详细说明：
实施例1：
按照下列配比称取原料和辅料：佛手1500份、香橼1000份、重瓣红玫瑰500份、r-氨基丁酸80份；麦芽糊精1000份、D-甘露糖醇50份、羧甲基纤维素钠100份、罗汉果甜苷5份、玫瑰冻干粉100份。
制备方法：（1）前处理：麦芽糊精、D-甘露糖醇粉碎过80目筛，备用；按配方量称取佛手、香橼、r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉备用；（2）煎煮：佛手、香橼加水12倍煎煮1小时，过滤（200目），备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.05～1.15（60℃）的流浸膏（药材：药液约为1:1.5），离心,取上清液，上清液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.20～1.30（60℃）的流浸膏，减压干燥（-0.08～-0.10MPa，50～70℃）至干，得干浸膏备用；（4）粉碎过筛：备用干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：将r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉置高效湿法制粒机上搅拌混合均匀，用85%乙醇（用量约为配方重量8%）作为润湿剂制软材，16目制粒，60℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）混合：将玫瑰冻干粉与上述备用干颗粒等量递增混匀至配方总量的5%后，加入上述剩余颗粒混合均匀，得总混物，备用；（7）内包装：备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例2：
按照下列配比称取原料和辅料：佛手6000份、香橼4000份、重瓣红玫瑰2000份、r-氨基丁酸300份；麦芽糊精4000份、D-甘露糖醇300份、羧甲基纤维素钠500份、罗汉果甜苷30份、玫瑰冻干粉500份。
制备方法：（1）前处理：麦芽糊精、D-甘露糖醇粉碎过80目筛，备用；按配方量称取佛手、香橼、r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉备用；（2）煎煮：佛手、香橼加水12倍煎煮1小时，过滤（200目），备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.05～1.15（60℃）的流浸膏（药材：药液约为1:1.5），离心,取上清液，上清液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.20～1.30（60℃）的流浸膏，减压干燥（-0.08～-0.10MPa，50～70℃）至干，得干浸膏备用；（4）粉碎过筛：备用干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：将r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉置高效湿法制粒机上搅拌混合均匀，用85%乙醇（用量约为配方重量8%）作为润湿剂制软材，16目制粒，60℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）混合：将玫瑰冻干粉与上述备用干颗粒等量递增混匀至配方总量的5%后，加入上述剩余颗粒混合均匀，得总混物，备用；（7）内包装：备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例3：
按照下列配比称取原料和辅料：佛手3000份、香橼2000份、重瓣红玫瑰1000份、r-氨基丁酸150份；麦芽糊精2885份、D-甘露糖醇150份、羧甲基纤维素钠250份、罗汉果甜苷15份、玫瑰冻干粉250份。
制备方法：（1）前处理：麦芽糊精、D-甘露糖醇粉碎过80目筛，备用；按配方量称取佛手、香橼、r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉备用；（2）煎煮：佛手、香橼加水12倍煎煮1小时，过滤（200目），备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.05～1.15（60℃）的流浸膏（药材：药液约为1:1.5），离心,取上清液，上清液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度为1.20～1.30（60℃）的流浸膏，减压干燥（-0.08～-0.10MPa，50～70℃）至干，得干浸膏备用；（4）粉碎过筛：备用干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：将r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉置高效湿法制粒机上搅拌混合均匀，用85%乙醇（用量约为配方重量8%）作为润湿剂制软材，16目制粒，60℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）混合：将玫瑰冻干粉与上述备用干颗粒等量递增混匀至配方总量的5%后，加入上述剩余颗粒混合均匀，得总混物，备用；（7）内包装：备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
Claims (7)
1.一种气郁体质保健固体饮料，其特征在于是由下述原料重量配比制备而成的制剂：佛手1500～6000份、香橼1000～4000份、重瓣红玫瑰500～2000份、r-氨基丁酸80～300份。
2.如权利要求1所述的一种气郁体质保健固体饮料，其原料的重量配比是：佛手2000～4000份、香橼1500～3000份、重瓣红玫瑰800～1500份、r-氨基丁酸100～200份。
3.如权利要求1～2之一所述的一种气郁体质保健固体饮料，其原料的重量配比是：佛手3000份、香橼2000份、重瓣红玫瑰1000份、r-氨基丁酸150份。
4.如权利要求1～3之一所述的一种气郁体质保健固体饮料，其特征在于制备方法是采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。
5.如权利要求4所述的一种气郁体质保健固体饮料的制备方法，其特征在于颗粒剂的制备方法是按上述原料组合配比，通过以下步骤制备：（1）前处理：麦芽糊精、D-甘露糖醇粉碎过80目筛，备用；按配方量称取佛手、香橼、r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷、玫瑰冻干粉备用；（2）煎煮：佛手、香橼加水12倍煎煮1小时，200目过滤，备用；（3）滤液浓缩干燥：滤液经-0.06～-0.08MPa，50～70℃减压浓缩至相对密度为60℃时测1.05～1.15的药材：药液约为1:1.5流浸膏，离心,取上清液，上清液-0.06～-0.08MPa，50～70℃减压浓缩至相对密度为60℃时测1.20～1.30的流浸膏，-0.08～-0.10MPa，50～70℃减压干燥至干，得干浸膏备用；（4）粉碎过筛：备用干浸膏粉碎过80目，得干浸膏粉，备用；（5）混合、制粒：将r-氨基丁酸、麦芽糊精、D-甘露糖醇、羧甲基纤维素钠、罗汉果甜苷，与备用的干浸膏粉置高效湿法制粒机上搅拌混合均匀，用85%乙醇用量约为配方重量8%作为润湿剂制软材，16目制粒，60℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）混合：将玫瑰冻干粉与上述备用干颗粒等量递增混匀至配方总量的5%后，加入上述剩余颗粒混合均匀，得总混物，备用；（7）内包装：备用总混物装袋，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
6.如权利要求5所述的一种气郁体质保健固体饮料颗粒剂的制备方法，其特征在于颗粒剂辅料加入麦芽糊精1000～4000份、D-甘露糖醇50～300份、羧甲基纤维素钠100～500份、罗汉果甜苷5～30份、玫瑰冻干粉100～500份。
7.如权利要求1～3之一所述的固体饮料在制备用于气郁体质保健药物的应用。
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