CN113018404A - 一种血瘀体质保健固体饮料及其制备方法 - Google Patents
一种血瘀体质保健固体饮料及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种血瘀体质保健固体饮料。它是主要由姜黄、三七花、葛根，加辅料麦芽糊精、异麦芽酮糖醇、D‑甘露糖醇、罗汉果甜苷、山楂速溶粉制成，采用药学上可接受的载体或赋形剂制成的药剂，包括颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂等。有活血化瘀、保护心脑血管、调节神经功能紊乱之功效，适用于血瘀体质人群，以及有血瘀体质症状的人群服用，主要表现为面色晦黯，皮肤粗糙呈褐色，色素沉着，或有紫斑，口唇黯淡，舌质青紫或有瘀点，脉细涩。临床使用表明本发明可改善血瘀体质的症状，未见不良反应。
Description
技术领域
本发明涉及一种血瘀体质保健固体饮料及其制备方法。
背景技术
血瘀体质是人体脏腑功能失调时，出现体内血液运行不畅或内出血不能消散而成瘀血内阻的体质，常表现面色晦黯，皮肤粗糙呈褐色，色素沉着，或有紫斑，口唇黯淡，舌质青紫或有瘀点，脉细涩。发病倾向：易患症瘕、痛症及血证。
中医药在治疗血瘀体质方面积累了丰富经验，疗效确切，亟待研究开发。中医认为血瘀体质多因七情不畅，寒冷侵袭，年老体虚、久病未愈等病因而发病，常随瘀血阻滞脏腑经络部位不同而出现不同的症状，治疗应以活血化瘀为总治则，结合脏腑经络辨证，用药以汤剂为主，使用不便。
本发明针对血瘀体质选用君药：姜黄活血行气，通经，止痛。《日华子本草》：治症瘕血块，痈肿，通月经，治跌扑瘀血，消肿毒；止暴风痛冷气，下食。臣药：三七花助君药活血化瘀。《中华本草》记载三七花“性甘味凉。清热生津，平肝降压”，现代药理研究表明，三七花中提取的总皂苷能明显降低血瘀大鼠的全血比粘度 ,降低其红细胞压积 ,延长凝血酶原的时间，降低纤维蛋白的数量，可以有效的预防血小板的聚集，防止血液粘度增加，从而起到预防血栓的作用，说明三七花具有活血化瘀的临床功效。佐使药：结合现代研究，血瘀体质多有心脑血管神经功能紊乱，为此，加入葛根（提取葛根总黄酮）保护心脑血管、调节神经功能紊乱，现代药理研究表明，葛根总黄酮可以通过直接扩张脑血管、增加脑血流量来改善脑循环、提高脑血管功能来保证脑部组织细胞所需的供血和供氧量，有效的降低神经功能紊乱的发生。诸药合用，具有活血化瘀、保护心脑血管、调节神经功能紊乱之功效。
本发明与现有血瘀体质专利技术比较如下。经检索中国知网专利库，涉及血瘀体质专利申请共40项，其申请（专利）号、名称和组方如下：（1）[申请号]CN201810354784.6一种组合物,其特征在于：它是包括下述重量配比的原料制备而成的制剂：桃仁300-700份、陈皮200-600份、山楂200-400份或藏红花提取物50-200份。（2）[申请号]CN201910795355.7一种干预血瘀体质的中药破壁组合物和制备方法。由中药组合物、填充剂和矫味剂组成的原料经破壁得到中药破壁粉后，通过制粒制备而成；中药组合物、填充剂与矫味剂的质量比为2：(0.5～2)：(0.5～3)；中药组合物按重量份数计，由山楂6～14份、桃仁6～14份、玫瑰花3～7份、桔梗3～7份、陈皮2～4份和葛根6～14份组成；中药破壁粉的粒径为20～40μm；中药破壁组合物颗粒的粒径为20～60目。（3）[申请号]CN201910097406.9一种调理血瘀体质的中药泡浴抑菌液/颗粒及制备与使用方法，所述中药泡浴抑菌液/颗粒的原料包括如下重量份的组分：路路通5-35份，苏木5-35份，川芎5-35份，川牛滕5-35份，乳香5-35份，薄荷5-35份，银耳5-50份。（4）[申请号]CN201811305825.9一种改善血瘀体质的功能食品及其制备方法，由以下重量份原料提取制备：丹凤牡丹花1-15份、重瓣红玫瑰1-15份、桃仁1-15份、姜黄0.5-10份、肉桂0.2-5份、雪莲培养物0.02-1份。（5）[申请号]CN201710859321.0一种改善血瘀体质的食品，其特征在于包含：基质粉和体质粉；其中所述基质粉包含糙米、大豆蛋白粉、大豆膳食纤维、薏米、燕麦、小麦胚芽，所述体质粉包含沙棘、玫瑰花、葛根、炒决明子、山楂、陈皮。（6）[申请号]CN201811404256.3一种改善血瘀体质的养生浸膏，其特征在于包括下列重量份原料：桃仁5-15份、山楂5-15份、人参5-15份、陈皮5-15份、玫瑰花5-15份、龙眼肉5-15份、葛根5-15份、红枣5-15份、佛手5-15份、桔梗5-15份、生麦芽1-15份、白果1-15份、薄荷1-15份、生姜1-15份、白芷1-15份、甘草1-15份。（7）[申请号]CN201811411475.4一种改善血瘀体质袋泡茶制备方法，其组分的重量百分比为：桃仁5-15%、山楂5-15%、人参5-15%、陈皮5-15%、玫瑰花5-15%、龙眼肉5-15%%、葛根5-15%、红枣5-15%、佛手5-15%、桔梗5-15%、生麦芽1-10%、白果1-10%、薄荷1-10%、生姜1-10%、白芷1-10%、甘草1-10%。（8）[申请号]CN201810498087.8一种针对血瘀体质人群的保健茶的制备方法，其特征在于，包括以下步骤：(1)将原料丹参、丝瓜络、姜黄、山楂叶、月季花洗净除杂，备用；(2)分别取洗净除杂后的原料进行真空冷冻干燥，然后粉碎成颗粒；(3)将步骤(2)所得的颗粒和超微和田玉粉充分混合均匀，灭菌，包装即得保健茶。（9）[申请号]CN201810059234.1一种用于血瘀体质的营养套餐，由韭菜炒鸡蛋、凉拌栗笋、益母草红枣瘦肉汤、山桃包和青楂茶组成。（10）[申请号]CN201711242628.2一种用于调理血瘀体质的固体饮料。该固体饮料包括以下重量份数的原料组分：21～55份的山楂、9～33份的桃仁、9～33份的白果、5～21份的桔梗、9～33份的橘红、0.5～4份的肉桂、9～33份的葛根、2～21份的白芷、10～29份的糊精、7～25份的麦芽糊精、8～26份的可溶性淀粉和0.05～0.2份的阿斯巴甜。（11）[申请号]CN201711428988.1一种用于调理血瘀体质的中药膏方。该中药膏方包括以下重量份数的原料组分：生地5～19份、赤芍6～17份、当归6～15份、川芎3～14份、益母草7～18份、桃仁6～15份、红花2～10份、生甘草1～5份、枳壳6～15份、桔梗4～13份、牛膝4～13份、玫瑰花5～17份、丹皮3～14份、葛根10～27份、香附3～9份、生蒲黄5～16份、官桂1～5份、地龙6～17份、鸡血藤13～30份、秦艽6～14份、黄芪8～17份、天花粉8～17份、丹参7～17份、三七粉6～16份、茜草7～16份、生山楂12～31份、阿胶5～15份、鳖甲胶10～22份、龟板胶9～21份、木糖醇20～40份、炮山甲3～9份。（12）[申请号]CN201711129356.5一种药物组合物，它是由下述重量配比的原料药制备而成的制剂：红花1～10份、葛根10～30份、佛手5～15份、姜黄6～14份、生山楂18～28份、当归5～15份。（13）[申请号]CN201710927441.X一种改善血瘀体质的茶饮，其百分比组成为：方剂提取液65～80％、儿茶提取液10～17％、植物组合提取液10～18％；其中，所述方剂的重量比组成为：三七:当归:莪术:白芷:薏苡:桃仁＝(6～25):(6～18):(3～15):(3～10):(3～10):(3～10)；所述的植物组合的重量比组成为：红枣:枸杞:山稔子:菊花＝(3～15):(3～15):(3～15):(3～10)。（14）[申请号]CN201610367381.6一种治疗女性血瘀体质黄褐斑的中药方剂，涉及中药领域。其由含有下述重量配比的原料药制备而成：玫瑰花，牡丹花，桃仁，山楂，葛根，佛手，生麦芽，薄荷，白芷。（15）[申请号]CN201710698511.9一种针对血瘀体质按摩中药油乳，其组分按重量份包括：桔红2～9份、桔梗2～15份、桃仁5～15份、桂枝5～15份、三七5～15份、川芎5～15份、水蛭粉10～20份、葛根2～10份、杜仲5～10份、山药5～16份、甘草3～15份、茶树花2～9份、白果2～9份、决明子2～9份、薄荷2～9份、人参10～20份、玫瑰花1～8份。（16）[申请号]CN201710430986.X一种调理血瘀体质的健康茶饮品及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、葛根10～15﹪、肉桂8～10﹪、昆布8～10﹪、山楂8～10﹪、桃仁1～2﹪、甘草5～8﹪、橘皮20～30﹪、桑叶8～10﹪，经混合、干燥、粉碎、过筛、杀菌、装袋获得产品。（17）[申请号]CN201710723366.5一种改善血瘀体质的茶饮，其百分比组成为：方剂提取液65～80％、儿茶提取液10～17％、植物组合提取液10～18％；其中，所述方剂的重量比组成为：三七:当归:莪术:白芷:薏苡:桃仁＝(6～25):(6～18):(3～15):(3～10):(3～10):(3～10)；所述的植物组合的重量比组成为：红枣:枸杞:山稔子:菊花＝(3～15):(3～15):(3～15):(3～10)。（18）[申请号]CN201710441880.X一种调理血瘀体质的膏滋方便食品及其制备方法，按原料的重量百分比组成：蜂蜜8～10﹪、人参(人工种植)3～5﹪、葛根10～15﹪、肉桂8～10﹪、昆布8～10﹪、山楂8～10﹪、桃仁1～2﹪、甘草6～8﹪、橘皮20～30﹪，经混合、搅拌、蒸煮、过滤、灌装、杀菌获得产品。（19）[申请号]CN201710437526.X一种调理血瘀体质的养生固体饮料及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、葛根10～15﹪、肉桂8～10﹪、昆布8～10﹪、山楂8～10﹪、桃仁1～2﹪、甘草5～8﹪、橘皮20～30﹪、低聚果糖3～5﹪、麦芽糊精3～5﹪，经混合、干燥、粉碎、整粒、杀菌、装袋获得产品。（20）[申请号]CN201710136446.0一种改善血瘀体质类型达到平和体质类型的药酒及其配方，包括纯粮白酒和药材；所述药材包括高丽参、当归、羌活、川芎、白芍、党参、五加皮、雪莲、牛膝、杜仲、丹参、黄芪、红花、牡丹皮、桂枝、玉竹、灵芝。（21）[申请号]CN201710441880.X一种调理血瘀体质的膏滋方便食品及其制备方法，按原料的重量百分比组成：蜂蜜8～10﹪、人参(人工种植)3～5﹪、葛根10～15﹪、肉桂8～10﹪、昆布8～10﹪、山楂8～10﹪、桃仁1～2﹪、甘草6～8﹪、橘皮20～30﹪，经混合、搅拌、蒸煮、过滤、灌装、杀菌获得产品。（22）[申请号]CN201710723366.5一种改善血瘀体质的茶饮，其百分比组成为：方剂提取液65～80％、儿茶提取液10～17％、植物组合提取液10～18％；其中，所述方剂的重量比组成为：三七:当归:莪术:白芷:薏苡:桃仁＝(6～25):(6～18):(3～15):(3～10):(3～10):(3～10)；所述的植物组合的重量比组成为：红枣:枸杞:山稔子:菊花＝(3～15):(3～15):(3～15):(3～10)。（23）[申请号]CN201710430986.X一种调理血瘀体质的健康茶饮品及其制备方法，按原料的重量百分比组成：人参(人工种植)3～5﹪、葛根10～15﹪、肉桂8～10﹪、昆布8～10﹪、山楂8～10﹪、桃仁1～2﹪、甘草5～8﹪、橘皮20～30﹪、桑叶8～10﹪，经混合、干燥、粉碎、过筛、杀菌、装袋获得产品。（24）[申请号]CN201610367381.6一种治疗女性血瘀体质黄褐斑的中药方剂，涉及中药领域。其由含有下述重量配比的原料药制备而成：玫瑰花，牡丹花，桃仁，山楂，葛根，佛手，生麦芽，薄荷，白芷。（25）[申请号]CN201710698511.9一种针对血瘀体质按摩中药油乳，其组分按重量份包括：桔红2～9份、桔梗2～15份、桃仁5～15份、桂枝5～15份、三七5～15份、川芎5～15份、水蛭粉10～20份、葛根2～10份、杜仲5～10份、山药5～16份、甘草3～15份、茶树花2～9份、白果2～9份、决明子2～9份、薄荷2～9份、人参10～20份、玫瑰花1～8份。（26）[申请号]CN201610018386.8一种用于血瘀体质的药食配方，是由如下重量份数的原料组成的：桃仁5-10份、人参3-9份、陈皮3-10份、玫瑰花2-6份、龙眼肉9-15份、葛根10-15份、山楂9-12份、大枣6-15份、甘草(炙)2-10份。（27）[申请号]CN201610297929.4一种调理血瘀体质的调理餐，由下列质量份数的原料制成：玉米15～20份、葛根5～10份、黄豆10～15份、桃仁5～10份、黑豆10～15份、山楂3～5份、玫瑰花10～15份、人参15～20份、桑椹子10～15份、核桃10～15份、粳米7～10份、冰糖12～15份。（28）[申请号]CN201310267489.4一种血瘀体质养生粥，其原料各组分质量份数为：黄豆80-120、黑木耳50-80、川芎5-10、山药50-70、玫瑰花5-10、大枣70-90、地瓜叶40-60、当归5-10、核桃50-80、黑芝麻60-90、小麦苗粉70-130、葡萄籽粉120-160。（29）[申请号]CN201410538262.3一种食品，具体的说是一种改善血瘀体质的食品及其制备工艺。本发明改善血瘀体质的食品，通过合理配伍，可使个别药味的功效产生协同作用，具有改善血瘀体质的面色常黯，发易脱落，红丝攀睛，肌肤或甲错或瘀斑，心烦心悸，健忘时作，舌质多黯，或有瘀点等症状作用。（30）[申请号]CN201510507005.8调节血瘀体质的组合物由以下原料构成，燕麦8-10；小麦胚芽20-25；荞麦4-5；山楂8-10；黄豆4-5；麦胚活性肽4-5；火麻仁4-5；核桃4-5；沙棘8-10；阿胶4-5；桃仁4-5；葡萄籽8-10；亚麻籽8-10；大米70-75；银杏8-10；葛根4-5。（31）[申请号]CN201510517414.6一种针对气滞血瘀体质调理的中药复合酵素及其制备方法。所述的复合酵素制备原料由中药部分和蔬果部分组成，中药部分包括如下质量份数的组份：丹参8份、川芎8份、赤芍8份、桃仁8份、姜黄8份、牛膝8份、人参2份；蔬果部分包括如下质量份数的组份：山楂28份、金桔28份、木瓜28份、阿萨伊果28份、番茄28份、菠萝28份、大蒜8份。（32）[申请号]CN201510504195.8一种调理血瘀体质的保健品，包括以下质量份数的原料：阿胶0.1-5份、金银花1-8份、香橼1-8份、佛手1-8份、桃仁1-10份、山楂1-10份，或还添加葛根1-10份、杜仲雄花1-5份、山药1-6份、甘草1-5份、茶树花1-8份、白果1-8份、决明子1-6份、薄荷1-9份、马齿苋1-6份、沙棘1-8份、昆布1-7份、桔红1-8份、桔梗1-5份、荷叶1-6份、黄芥子1-6份、蒲公英1-8份、龙眼肉1-9份、桑叶1-8份、辣木叶1-6份、雪莲培养物0.1-5份、短梗五加1-6份、奇亚籽0.1-1份、玫瑰花1-5份。（33）[申请号]CN201410102211.6一种调理血瘀体质酵素及其制备方法，其特征是：一种以黑米、黑木耳、绿豆、花生、油菜、甘蔗、黄瓜、山楂经由益生菌群发酵后制取出调理血瘀体质酵素。（34）[申请号]CN201410182667.8一种血瘀体质保健食品及其制备方法，该保健食品以药食同源原料桃仁、山楂、鸡内金、黑蒜为有效药物组分以及在药品和食品中允许使用的辅助添加成分组成，以重量份计的各有效药食两用组分的生药原料组成为：桃仁40～125份、山楂60～175份、鸡内金40～160份和黑蒜30～150份。（35）[申请号]CN201410243852.3一种调理血瘀体质茶，其特征在于包括以重量计的下列组分：山栀900g～1100g、决明子900g～1100g、桃仁～900g～1100g、山楂900g～1100g、荷叶900g～1100g、沙棘～900g～1100g、蚕蛹900g～1100g、葛根900g～1100g、红曲米900g～1100g、菊花900g～1100g、杏仁900g～1100g、茯苓900g～1100g、桑葚800g～1000g、桑叶800g～1000g、干姜800g～1000g、白芷700g～900g、山药800g～1000g、昆布700g～900g。（36）[申请号]CN201410106435.4一种治疗血瘀体质的足浴中药，其特征在于：由以下原料制成：玫瑰花、桂枝、红花、大黄、荔枝核、大横纹、丰花草、黄水枝、荃皮、松毛火绒草、石夹生、水狼萁、银紫丹参、匙叶草、七里香；所述原料由以下重量份数配比组成：玫瑰花15g、桂枝10g、红花10g、大黄6g、荔枝核30g、大横纹3g、丰花草3g、黄水枝3g、荃皮3g、松毛火绒草6g、石夹生6g、水狼萁9g、银紫丹参12g、匙叶草4g、七里香8g。（37）[申请号]CN201210349161.2一种治疗血瘀体质的组合物，其特征在于包括以下重量份的原料：桃仁7～11份、橘皮4～9份、山楂2～5份、黑芝麻3～7份、阿胶2～6份。（38）[申请号]CN201110099908.9一种用于气郁、血瘀体质人祛湿活血、软坚散结的中药制剂及其制备方法和应用，该中药制剂的药效成分包括以下质量份数的原料药：昆布20-70、乌梅30-50、蒲公英40-90、小茴香50-80、山楂30-60、桃仁40-80、沙棘50-80、牡蛎50-90、鸡内金20-40、代代花30-80、橘红20-70、橘络40-60、橘核20-70、枸杞子40-70、灵芝30-70、芦笋20-60、薏苡仁30-70、佛手50-80。（39）[申请号]CN201110099913.X一种用于血瘀体质的人缓解其症状的中药制剂、制备方法及应用，该中药制剂的药效成分包括以下质量份数的原料药：牡蛎40-80、桑葚50-110、葛根45-90、桃仁50-120、乌梢蛇10-15、丝瓜络20-60、山楂30-70、橘红20-50、橘络30-60、生姜40-80、木瓜50-90、黑木耳60-90。（40）[申请号]CN200410029562.5本发明涉及一种血瘀体质保健饮料及其制备方法，它是将山楂经常规预处理，除去腐烂，伤病果，清水洗涤，压破，加热软化，自然冷却渗浸，粗滤，精滤，滤液冷却备用；红花经常规预处理，分切，搅汁打浆，加水调温，加纤维素酶搅拌浸提后过滤得到红花提取液，与上述滤液混合，调温，加入果胶酶，搅拌均匀，静置，过滤，加入适量的糖和柠檬酸，过滤，杀菌，灌装，冷却即得。
本发明与以上现有血瘀体质40项申请（专利）比较，不同之处在于：处方组成明显不同。本发明技术原创性在于中医辨证与西医辨病相结合，组方上结合现代研究，血瘀体质多有心脑血管神经功能紊乱的关键问题，采用活血化瘀与保护心脑血管、调节神经功能紊乱结合，形成原创的创新保健产品。通过以上主权项比较，可以看出本发明与以上现有血瘀体质申请（专利）比，在主权项处方组成上与本发明无实质等同，说明以上申请（专利）对本发明的新颖性和创造性不构成实质性影响。
发明内容
本发明的目的在于提供一种血瘀体质保健固体饮料及其制备方法，适用于血瘀体质人群，以及有血瘀体质表现的人群服用，主要表现为面色晦黯，皮肤粗糙呈褐色，色素沉着，或有紫斑，口唇黯淡，舌质青紫或有瘀点，脉细涩。
本发明的技术方案：一种血瘀体质保健固体饮料，由姜黄、三七花、葛根制成，其特征在于是由下述原料成份和重量配比制备而成：姜黄500～2000份、三七花250～1000份、葛根1500～6000份；本发明优选重量配比范围是：姜黄700～1800份、三七花350～800份、葛根2000～5000份；本发明最佳重量配比范围是：姜黄1000份、三七花500份、葛根3000份。
一种血瘀体质保健固体饮料的制备方法，其特征在于颗粒剂的制备辅料加入麦芽糊精250～1000份、异麦芽酮糖醇1000～4000份、D-甘露糖醇750～3000份、罗汉果甜苷15～70份、山楂速溶粉50～200份。
一种血瘀体质保健固体饮料的制备方法，其特征在于采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。其颗粒剂制备方法按以下步骤：
1、配料称量、粉碎、过筛：按配料单称取三七花、葛根、姜黄；另取麦芽糊精、异麦芽酮糖醇、D-甘露糖醇分别粉碎过80目筛，备用；
2、提取：三七花、葛根、姜黄加6倍量水煎煮2次，第一次煎煮1.5小时，第二次煎煮1.0小时，合并滤液，备用；
3、滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.10～1.20（60℃测），高速离心，减压干燥（-0.08～-0.10MPa，50～70℃）至干浸膏，备用；
4、粉碎过筛：干浸膏粉碎过80目，备用；
5、混合、制粒：将干浸膏粉、麦芽糊精、异麦芽酮糖醇、D-甘露糖醇、罗汉果甜苷置于湿法制粒机中，用70%乙醇（用量约为配方重量10%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，得湿颗粒；将湿颗粒55℃干燥至水分≤5%，14目整粒，得干颗粒，备用；
6、总混：将山楂速溶粉与干颗粒置三维总混机中混合30min；
7、内包装：复合膜包装，5g/袋；
8、外包装：贴标签，装盒，装箱，待检验合格后入库；
9、检验入库：成品经检验合格后，入库。
本发明技术原创性在于中医辨证与西医辨病相结合，组方上结合现代研究，血瘀体质多有心脑血管神经功能紊乱的关键问题，采用活血化瘀与保护心脑血管、调节神经功能紊乱结合，形成原创的创新保健产品。其优点在于组方独特，疗效确切、安全、经济、无明显毒副作用，适用于血瘀体质人群，以及有血瘀证表现的人群服用，主要表现为面色晦黯，皮肤粗糙呈褐色，色素沉着，或有紫斑，口唇黯淡，舌质青紫或有瘀点，脉细涩。
本发明颗粒剂（姜黄、三七花、葛根制成）对有面色晦黯，皮肤粗糙呈褐色，色素沉着，或有紫斑，口唇黯淡等血瘀体质症状的人群试用（每次1袋，每天2次，连服2周）。疗效判定：自觉症状改善≥50%，为显效；<50%，为有效；无变化，为无效。结果表明，37例自愿受试者，显效24例，有效10例，无效3例；总有效率91.89%。服用期间未出现不良反应。
四、具体实施方式
下面以具体实施例对本发明作详细说明：
实施例1：
按照下列配比称取原料和辅料：姜黄500份、三七花250份、葛根1500份；麦芽糊精250份、异麦芽酮糖醇1000份、D-甘露糖醇750份、罗汉果甜苷15份、山楂速溶粉50份。
制备方法：（1）配料称量、粉碎、过筛：按配料单称取三七花、葛根、姜黄；另取麦芽糊精、异麦芽酮糖醇、D-甘露糖醇分别粉碎过80目筛，备用；（2）提取：三七花、葛根、姜黄加6倍量水煎煮2次，第一次煎煮1.5小时，第二次煎煮1.0小时，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.10～1.20（60℃测），高速离心，减压干燥（-0.08～-0.10MPa，50～70℃）至干浸膏，备用；（4）粉碎过筛：干浸膏粉碎过80目，备用；（5）混合、制粒：将干浸膏粉、麦芽糊精、异麦芽酮糖醇、D-甘露糖醇、罗汉果甜苷置于湿法制粒机中，用70%乙醇（用量约为配方重量10%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，得湿颗粒；将湿颗粒55℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将山楂速溶粉与干颗粒置三维总混机中混合30min；（7）内包装：复合膜包装，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例2：
按照下列配比称取原料和辅料：姜黄2000份、三七花1000份、葛根6000份；麦芽糊精1000份、异麦芽酮糖醇4000份、D-甘露糖醇3000份、罗汉果甜苷70份、山楂速溶粉200份。
制备方法：（1）配料称量、粉碎、过筛：按配料单称取三七花、葛根、姜黄；另取麦芽糊精、异麦芽酮糖醇、D-甘露糖醇分别粉碎过80目筛，备用；（2）提取：三七花、葛根、姜黄加6倍量水煎煮2次，第一次煎煮1.5小时，第二次煎煮1.0小时，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.10～1.20（60℃测），高速离心，减压干燥（-0.08～-0.10MPa，50～70℃）至干浸膏，备用；（4）粉碎过筛：干浸膏粉碎过80目，备用；（5）混合、制粒：将干浸膏粉、麦芽糊精、异麦芽酮糖醇、D-甘露糖醇、罗汉果甜苷置于湿法制粒机中，用70%乙醇（用量约为配方重量10%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，得湿颗粒；将湿颗粒55℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将山楂速溶粉与干颗粒置三维总混机中混合30min；（7）内包装：复合膜包装，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
实施例3：
按照下列配比称取原料和辅料：姜黄1000份、三七花500份、葛根3000份；麦芽糊精500份、异麦芽酮糖醇2208份、D-甘露糖醇1500份、罗汉果甜苷35份、山楂速溶粉100份。
制备方法：（1）配料称量、粉碎、过筛：按配料单称取三七花、葛根、姜黄；另取麦芽糊精、异麦芽酮糖醇、D-甘露糖醇分别粉碎过80目筛，备用；（2）提取：三七花、葛根、姜黄加6倍量水煎煮2次，第一次煎煮1.5小时，第二次煎煮1.0小时，合并滤液，备用；（3）滤液浓缩干燥：滤液减压浓缩（-0.06～-0.08MPa，50～70℃）至相对密度1.10～1.20（60℃测），高速离心，减压干燥（-0.08～-0.10MPa，50～70℃）至干浸膏，备用；（4）粉碎过筛：干浸膏粉碎过80目，备用；（5）混合、制粒：将干浸膏粉、麦芽糊精、异麦芽酮糖醇、D-甘露糖醇、罗汉果甜苷置于湿法制粒机中，用70%乙醇（用量约为配方重量10%，具体制粒使用的乙醇浓度及用量根据中试实际情况确定）作为润湿剂制软材，16目制粒，得湿颗粒；将湿颗粒55℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将山楂速溶粉与干颗粒置三维总混机中混合30min；（7）内包装：复合膜包装，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
其中，成品剂型还可以是采用药学上可接受的载体或赋形剂制成的其他剂型，如片剂、胶囊剂、软胶囊剂、滴丸剂、丸剂等。
Claims (7)
1.一种血瘀体质保健固体饮料，其特征在于是由下述原料重量配比制备而成的制剂：姜黄500～2000份、三七花250～1000份、葛根1500～6000份。
2.如权利要求1所述的一种血瘀体质保健固体饮料，其原料的重量配比是：姜黄700～1800份、三七花350～800份、葛根2000～5000份。
3.如权利要求1～2之一所述的一种血瘀体质保健固体饮料，其原料的重量配比是：姜黄1000份、三七花500份、葛根3000份。
4.如权利要求1～3之一所述的一种血瘀体质保健固体饮料，其特征在于制备方法是采用药学上可接受的载体或赋形剂制成的任何剂型，如颗粒剂、片剂、胶囊剂、软胶囊剂、滴丸剂或丸剂。
5.如权利要求4所述的一种血瘀体质保健固体饮料的制备方法，其特征在于颗粒剂的制备方法是按上述原料组合配比，通过以下步骤制备：（1）配料称量、粉碎、过筛：按配料单称取三七花、葛根、姜黄；另取麦芽糊精、异麦芽酮糖醇、D-甘露糖醇分别粉碎过80目筛，备用；（2）提取：三七花、葛根、姜黄加6倍量水煎煮2次，第一次煎煮1.5小时，第二次煎煮1.0小时，合并滤液，备用；（3）滤液浓缩干燥：滤液经-0.06～-0.08MPa，50～70℃减压浓缩至相对密度60℃时测1.10～1.20，高速离心，-0.08～-0.10MPa，50～70℃减压干燥至干浸膏，备用；（4）粉碎过筛：干浸膏粉碎过80目，备用；（5）混合、制粒：将干浸膏粉、麦芽糊精、异麦芽酮糖醇、D-甘露糖醇、罗汉果甜苷置于湿法制粒机中，用70%乙醇用量约为配方重量10%作为润湿剂制软材，16目制粒，得湿颗粒；将湿颗粒55℃干燥至水分≤5%，14目整粒，得干颗粒，备用；（6）总混：将山楂速溶粉与干颗粒置三维总混机中混合30min；（7）内包装：复合膜包装，5g/袋；（8）外包装：贴标签，装盒，装箱，待检验合格后入库；（9）检验入库：成品经检验合格后，入库。
6.如权利要求5所述的一种血瘀体质保健固体饮料颗粒剂的制备方法，其特征在于颗粒剂辅料加入麦芽糊精250～1000份、异麦芽酮糖醇1000～4000份、D-甘露糖醇750～3000份、罗汉果甜苷15～70份、山楂速溶粉50～200份。
7.如权利要求1～3之一所述的固体饮料在制备用于血瘀体质保健药物的应用。
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