CN110038085A - 一种复方酸枣仁组合提取物的制备方法和用途 - Google Patents
一种复方酸枣仁组合提取物的制备方法和用途 Download PDFInfo
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- CN110038085A CN110038085A CN201910407808.4A CN201910407808A CN110038085A CN 110038085 A CN110038085 A CN 110038085A CN 201910407808 A CN201910407808 A CN 201910407808A CN 110038085 A CN110038085 A CN 110038085A
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Abstract
本发明涉及中药制剂加工及功能性食品加工领域,具体涉及一种复方酸枣仁组合提取物的制备方法和用途。本发明的一种复方酸枣仁组合提取物的制备方法,其特征是由以下重量份的中药原料酸枣仁8‑12份,百合6‑10份,茯苓6‑10份,桑椹6‑10份,枸杞子5‑9份,桂圆肉6‑10份,黄精6‑10份和与中药原料等重量份的环糊精制成。本发明的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂、口服液作为制备功能性食品或酒品的用途。
Description
技术领域
本发明涉及中药制剂加工及功能性食品加工领域,具体涉及一种复方酸枣仁组合提取物及其制备方法和用途。
背景技术
由于现代人们生活节奏加快,生活压力大,生活结构的变化,生活中一些特有疾病也相应地呈现增多趋势。如常因压力大,造成身心疲惫,心悸怔忡,失眠多梦,精神焦虑,神经衰弱等,给人们的身心健康带来一定的影响。心藏神,肝藏魂,人体的精神、意识、思维活动,与心、肝二脉密切相关。《素问·举痛论》云:“惊则心无所依,神无所归,虚无所定,故气乱矣。”《景岳全书》云:“无邪而不寐者,必营气不足也,营主血,血虚则无以养心,心虚则神不守舍。”说明心神受扰或心神失养,均会导致心神不宁病症,出现心烦失眠,健忘多梦,心悸怔忡等神识异常的症状。
本发明利用具有养心补脾,宁心安神之功的酸枣仁、清心安神之功的百合、有健脾宁心的茯苓、具滋阴补血之功的桑椹、滋补肝肾之功的枸杞子以及养气补阴、健脾益肾功效之功的黄精、养血安神之功的桂圆组成复方药用组合,并制备成该复方酸枣仁组合提取物作为制备保健品的用途,经检索,目前尚未有相关专利申请。
发明内容
本发明的目的在于提供一种复方酸枣仁组合提取物的制备方法,本发明的目的还在于提供该复方酸枣仁组合提取物作为制备功能性食品的用途。
本发明提供的一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁8-12份,百合6-10份,茯苓6-10份,桑椹6-10份,枸杞子5-9份,桂圆肉6-10份,黄精6-10份和与中药原料等重量份的环糊精制成,其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
本发明所述的酒精,在没有作出特定说明时,均为食用级酒精。
本发明中所述的水,在没有特定说明时,均为纯净水。
本发明上述所述的干燥,为采用真空干燥,其真空干燥的条件为温度50℃、真空度为0.2kPa。
本发明所述的复方酸枣仁组合提取物按常规工艺作为制成片剂、胶囊剂、颗粒剂、丸剂、口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物作为制备酒制品的用途。
本发明上述所述的环糊精(CYD),可以是β-环糊精(β-CYD),也可以是2,6-二甲基-β-环糊精(DM-β--CYD)、羟乙基-β-环糊精(HE-β-CYD)、羟丙基-β-环糊精(HP-β-CYD)和磺丁基醚-β-环糊精(SBE-β-CYD)中的任意一种。
CYD安全无毒,根据世界卫生组织对食品添加剂的有关规定(FAQ营养学会议NO46WHO/FOOD ADD/70.36),酶化学特征的淀粉无需再做毒性研究;许多试验研究也证明β-CYD具在很高的安全,急性毒性试验显示小鼠口服其LD50>300 mg/kg,急性毒性和慢性毒性试验,致畸致癌、致突变试验等证明了本品使用安全无毒。美国、日本的药典己将B-CYD收载为口服辅料:HP-B-CYD(羟丙基-B-环糊精)已被美国药典和Wade A编著的《Handboofk ofPharrnaceutical Excipients》收载为注射用辅料(赵洁如等主编,现代中药制剂新技术,江苏科学技术出版社,2007年2月第1版,151页)。
本发明优选的一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁9-11份,百合7-9份,茯苓7-9份,桑椹7-9份,枸杞子6-8份,桂圆肉7-9份,黄精7-9份和与中药原料等重量份的环糊精制成,
其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
本发明进一步优选的一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁10份,百合8份,茯苓8份,桑椹8份,枸杞子7份,桂圆肉8份,黄精8份和与中药原料等重量份的环糊精制成,
其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
酸枣仁为鼠李科植物酸枣Ziziphus jujuba Mill.var.spinosa(Bunge)Hu etH.F.chou的干燥成熟种子。性味甘、酸,平。归肝、胆、心经。具养心补肝,宁心安神,敛汗,生津功能。用于虚烦不眠,惊悸多梦,体虚多汗,津伤口渴。
效用分析:酸枣仁味甘能补,入肝、心二经,有养心阴、益肝血而宁心安神之效,为养心安神要药,主治心肝阴血不足、心失所养,神不守舍所致心悸怔忡,虚烦不眠,多梦等。
酸枣仁味酸能敛,有收敛止汗之效,用治体虚多汗,盗汗;并有酸甘化阴、生津止渴之功,可用治津伤口渴咽干之症(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,1000-1001页)。
百合为百合科植物卷丹Lilium lanci folium Thunb.、百合Lilium brouniiF.E.Brown var.uiridulum Baker或细叶百合Lilium pumilum DC.的干燥肉质鳞叶。性味甘,寒。归心、肺经。具有养阴润肺,清心安神功能。用于阴虚燥咳,劳嗽咯血,虚烦惊悸,失眠多梦,精神恍惚。
效用分析:百合入心经,又能养心阴,清心热而安心神,《本草衍义》云:“治伤寒坏后百合病”。故可用于治热病伤阴,气津不足,虚烦惊悸,心烦口渴,失眠多梦,甚则神志恍惚,沉默寡言之证;亦可用于百合病邪郁日久,心烦口渴,小便赤涩者(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,1215页)。
茯苓为多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核。性味甘、淡,平。归心、肺、脾、肾经。具利水渗湿,健脾,宁心功效。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。效用分析:茯苓入心脾二经,能补脾而助气血生化之源,使心有所养,又具有宁心安神之功效,临床多用于惊悸失眠,对心脾亏虚所致的心神不安尤为适宜(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,546-547页)。
桑椹为桑科植物桑Morus alba L.的干燥果穗。性味甘、酸,寒。归心、肝、肾经。具滋阴补血,生津润燥功能。用于肝肾阴虚,眩晕耳鸣,心悸失眠,须发早白,津伤口渴,内热消渴,肠燥便秘。效用分析:桑棋味甘酸,功专滋阴补血,《滇南本草》云:“益肾脏而固精,久服黑发明目”。故常用于肝肾不足,阴血亏虚之眩晕耳鸣,目暗昏花,腰膝酸软,须发早白等(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,1238页)。
枸杞子为茄科植物宁夏枸杞Lycium barbarum L.的干燥成熟果实。性味甘,平。归肝、肾经。具滋补肝肾,益精明目功能。用于虚劳精亏,腰膝酸痛,眩晕耳鸣,阳痿遗精,内热消渴,血虚萎黄,目昏不明。效用分析:枸杞子味甘性平,入肝肾经,长于滋肾精,补肝血,《本草经疏》言其:“为肝肾真阴不足,劳乏内热补益之要药”,对肝肾精血亏虚所致腰膝酸软、眩晕耳鸣、遗精滑精、不孕不育、目昏不明等均可应用。枸杞子能益精血、“安神”(《药性论》),可用于血虚面色萎黄,心悸乏力;产后风虚劳损,四肢疼痛,心神虚烦,不欲饮食;血虚咳嗽,盗汗自汗,骨蒸潮热,五心烦热;劳伤虚损,四肢羸瘦乏力;妇人产后气血虚弱,乳汁过少等(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,1230页)。
桂圆肉又称龙眼肉,始载《神农本草经》,列为上品。桂圆肉为无患子科常绿乔木植物龙眼Euphoria longan(Lour)Steud.的成熟干燥或半干燥的假种皮。性味甘、平。归经:入心、脾经。具补心脾,养血安神,益智功能。用于惊悸、健忘,失眠等症。临床主要用于治疗与心血虚有关的神经衰弱,表现有失眠、健忘、惊悸等症状(崔树德主编《中药大全》,黑龙江科学技术出版社出版,1989年8月第1版,第555-556页)。
黄精为百合科植物滇黄精Polygonatum kingianum Coll.et Hemsl.、黄精Polygonatum sibiricum Red.或多花黄精Polygonatum cyrtonema Hua的干燥根茎。性味甘,平。归脾、肺、肾经。具补气养阴,健脾,润肺,益肾功能。用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。效用分析:黄精味甘性平,主人脾经,既能滋养脾阴,又善补益脾气,是治疗脾胃虚弱,体倦乏力,口干食少之良药,故《名医别录》言其“补中益气”、《本草便读》称“此药味甘如饴,性质平润,为补养脾阴之正品”。黄精甘润性平,入肺经,既补肺阴,又兼能益气,为治疗肺虚之佳品,阴伤燥咳、肺虚劳嗽咳血及肺虚喘咳均可选用。黄精入肾经,长于滋阴,又兼益气,通过平补脾肺肾而能填精生髓,强壮固本,常用于治疗精血不足,腰膝酸软,须发早白,内热消渴(国家药典委员会编《中华人民共和国药典》·临床用药须知·中药饮片卷,2015年版,1227页)。
本发明复方酸枣仁组合提取物是由具有养心补肝,宁心安神之功酸枣仁、清心安神之功百合、健脾宁心之功茯苓、滋阴补血之功桑椹、滋补肝肾之功枸杞子、养血安神之功桂圆、养气补阴、健脾、益肾之功黄精组成,具有滋养心肝,益阴补血,宁心安神等作用,适用于心肝血虚,肝肾阴虚等引起的虚烦惊悸,失眠多梦,精神恍惚,心神不安,心悸失眠等症状的辅助性保健用品。
利用本发明复方酸枣仁组合利用现代加工工艺制备成的组合物,不仅可以作为保健食品内服食用或饮用,还可以根据需要配制成不同的口服剂型。可以将复方酸枣仁组合提取物与药学上或食品上可以接受的辅料混合配制成颗粒剂,片剂,胶囊,丸剂,口服液,酒制品等;其中片剂优选泡腾片、咀嚼片、口含片,因泡腾片、咀嚼片、口含片与普通片剂相比有以下几点明显优势:(1)服用方便,可嚼服、含服,可化水,由于配制这些片剂都要加入一定量的糖粉作为赋形剂,因而口感好,人们乐意服用,泡腾片加水自溶后犹如一杯饮料,使人们乐于饮用;(2)吸收快,生物利用度高;(3)便于携带,方便运输;(4)易于量化,用量相应准确;其中胶囊剂可制备成软胶囊剂和硬胶囊剂,其中丸剂可制备成水泛丸、滴丸、微丸和蜜丸;其中所述的酒制品可选用现有的白酒、葡萄酒、黄酒和啤酒,经勾兑、陈化常规方法制备成白酒、葡萄酒、黄酒和啤酒制品。
具体实施方式
通过以下实施例是对本发明作进一步的说明,但对本发明的范围不构成任何限制。
实施例1
复方酸枣仁组合提取物的制备
药物组合:酸枣仁0.8kg、百合1.0kg、茯苓1.0kg、桑椹1.0kg、枸杞子0.9kg、桂圆肉1.0kg、黄精1.0kg和6.7kgβ-环糊精,
制法:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取烘干后的酸枣仁0.8kg,粉碎成80目粉,称取烘干后的百合1.0kg、茯苓1.0kg、桑椹1.0kg、枸杞子0.9kg、桂圆肉1.0kg、黄精1.0kg混合粉碎成30目粉备用;(2)将酸枣仁粉加入浓度为99%v/v的酒精8.0kg,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精,得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入纯净水88.5kg,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再加入纯净水47.2kg,煮沸1小时,滤取煎煮液,滤渣再加入纯净水29.5kg,煮沸0.5小时,滤取煎煮液,弃去滤渣;(5)将步骤(4)所得三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,加入β-环糊精6.7kg,置于球磨机内充分研磨3小时,研磨结束后,取出物料,置入真空干燥机内,在温度为50℃、真空度为0.2kPa条件下干燥自物料含水量在5.5%,取出物料放冷后,经碾碎,过80目筛,即得复方酸枣仁组合提取物。
所述的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂或口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物按常规工艺制成酒品的用途。
实施例2
复方酸枣仁组合提取物的制备
药物组合:酸枣仁1.0kg、百合0.8kg、茯苓0.8kg、桑椹0.8kg、枸杞子0.7kg、桂圆肉0.8kg、黄精0.8kg和5.7kg的2,6-二甲基-β-环糊精,
制法:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取烘干后的酸枣仁1.0kg,粉碎成80目粉,称取烘干后的百合0.8kg、茯苓0.8kg、桑椹0.8kg、枸杞子0.7kg、桂圆肉0.8kg、黄精0.8kg混合粉碎成30目粉备用;(2)将酸枣仁粉加入浓度为99%v/v的酒精10kg,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精,得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入纯净水70.5kg,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再加入纯净水37.6kg,煮沸1小时,滤取煎煮液,滤渣再加入纯净水23.5kg,煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)所得三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,加入2,6-二甲基-β-环糊精5.7kg,置于球磨机内充分研磨3小时,研磨结束后,取出物料,置入真空干燥机内,在温度为50℃、真空度为0.2kPa条件下干燥自物料含水量在5.8%,取出物料放冷后,经碾碎,过80目筛,即得复方酸枣仁组合提取物。
所述的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂或口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物按常规工艺制成酒品的用途。
实施例3
复方酸枣仁组合提取物的制备
药物组合:酸枣仁1.2kg、百合0.7kg、茯苓0.7kg、桑椹0.7kg、枸杞子0.6kg、桂圆肉0.7kg、黄精0.7kg和5.3kg的磺丁基醚-β-环糊精,
制法:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取烘干后的酸枣仁1.2kg,粉碎成80目粉,称取烘干后的百合0.7kg、茯苓0.7kg、桑椹0.7kg、枸杞子0.6kg、桂圆肉0.7kg、黄精0.7kg混合粉碎成30目粉备用;(2)将酸枣仁粉加入浓度为99%v/v的酒精14.4kg,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精,得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入纯净水61.5kg,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再加入纯净水32.8kg,煮沸1小时,滤取煎煮液,滤渣再加入纯净水20.5kg,煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)所得三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,加入磺丁基醚-β-环糊精5.3kg,置于球磨机内充分研磨3小时,研磨结束后,取出物料,置入真空干燥机内,在温度为50℃、真空度为0.2kPa条件下干燥自物料含水量在5.6%,取出物料放冷后,经碾碎,过80目筛,即得复方酸枣仁组合提取物。
所述的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂或口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物按常规工艺制成酒品的用途。
实施例4
复方酸枣仁组合提取物的制备
药物组合:酸枣仁1.1kg、百合0.9kg、茯苓0.9kg、桑椹0.9kg、枸杞子0.5kg、桂圆肉0.6kg、黄精0.6kg和4.7kg的羟丙基-β-环糊精,
制法:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取烘干后的酸枣仁1.1kg,粉碎成80目粉,称取烘干后的百合0.9kg、茯苓0.9kg、桑椹0.9kg、枸杞子0.5kg、桂圆肉0.6kg、黄精0.6kg混合粉碎成30目粉备用;(2)将酸枣仁粉加入浓度为99%v/v的酒精11kg,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精,得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入纯净水88.5kg,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再加入纯净水28.8kg,煮沸1小时,滤取煎煮液,滤渣再加入纯净水18kg,煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)所得三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,加入β-环糊精4.7kg,置于球磨机内充分研磨3小时,研磨结束后,取出物料,置入真空干燥机内,在温度为50℃、真空度为0.2kPa条件下干燥自物料含水量在5.0%,取出物料放冷后,经碾碎,过80目筛,即得复方酸枣仁组合提取物。
所述的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂或口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物按常规工艺制成酒品的用途。
实施例5
复方酸枣仁组合提取物的制备
药物组合:酸枣仁0.9kg、百合0.6kg、茯苓0.9kg、桑椹0.6kg、枸杞子0.8kg、桂圆肉0.9g、黄精0.9kg和5.6kg的羟丙基-β-环糊精,
制法:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取烘干后的酸枣仁0.9kg,粉碎成80目粉,称取烘干后的百合0.6kg、茯苓0.9kg、桑椹0.6kg、枸杞子0.8kg、桂圆肉0.9kg、黄精0.9kg混合粉碎成30目粉备用;(2)将酸枣仁粉加入浓度为99%v/v的酒精9kg,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精,得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入纯净水70.5kg,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再加入纯净水37.6kg,煮沸1小时,滤取煎煮液,滤渣再加入纯净水23.5kg,煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)所得三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,加入β-环糊精5.6kg,置于球磨机内充分研磨3小时,研磨结束后,取出物料,置入真空干燥机内,在温度为50℃、真空度为0.2kPa条件下干燥自物料含水量在5.2%,取出物料放冷后,经碾碎,过80目筛,即得复方酸枣仁组合提取物。
所述的复方酸枣仁组合提取物按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂或口服液作为制备功能性食品的用途。
所述的复方酸枣仁组合提取物按常规工艺制成酒品的用途。
Claims (10)
1.本发明提供的一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁8-12份,百合6-10份,茯苓6-10份,桑椹6-10份,枸杞子5-9份,桂圆肉6-10份,黄精6-10份和与中药原料等重量份的环糊精制成,
其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
2.一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁9-11份,百合7-9份,茯苓7-9份,桑椹7-9份,枸杞子6-8份,桂圆肉7-9份,黄精7-9份和与中药原料等重量份的环糊精制成,
其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
3.一种复方酸枣仁组合提取物的制备方法,其特征在于,它是由以下重量份的中药原料酸枣仁10份,百合8份,茯苓8份,桑椹8份,枸杞子7份,桂圆肉8份,黄精8份和与中药原料等重量份的环糊精制成,
其制备方法如下:(1)首先分别将中药材酸枣仁、百合、茯苓、桑椹、枸杞子、桂圆肉、黄精进行烘干,称取酸枣仁粉碎成80目粉,称取烘干后的百合、茯苓、桑椹、枸杞子、桂圆肉、黄精混合粉碎成30目粉备用;(2)将酸枣仁粉按药材重量比例为1:10加入浓度为99%v/v的酒精,常温浸泡12天,浸泡期间每天充分搅拌一次,浸泡结束后,滤取酒精浸泡液保存备用,滤渣备用;(3)将步骤(2)所得酒精液回收酒精得浓缩液备用;(4)将百合、茯苓、桑椹、枸杞子、桂圆肉、黄精诸药材混合粉,加入中药材总重量比例为1:15的水中,常温浸泡4小时后,将步骤(1)所剩药渣加入,加热煮沸2小时,滤取煎煮液,药渣再按前述中药材总重量比例为1:8加水煮沸1小时,滤取煎煮液,滤渣再按前述中药材总重量比例为1:5加水煮沸0.5小时,滤取煎煮液弃去滤渣;(5)将步骤(4)三次煎煮液合并,过150目筛,经浓缩至5.0得浓缩液备用;(6)将步骤(3)所得浓缩液与步骤(5)所得浓缩液合并,按药材总量等重量比例加入环糊精,置于球磨机内充分研磨3小时,研磨结束后,取出物料,经干燥至含水量<6%/w,碾碎,过80目筛,即得复方酸枣仁组合提取物。
4.根据权利要求1、2、3所述的方法,其特征在于,所述的环糊精(CYD)为β-环糊精(β-CYD)、2,6-二甲基-β-环糊精(DM-β--CYD)、羟乙基-β-环糊精(HE-β-CYD)、羟丙基-β-环糊精(HP-β-CYD)和磺丁基醚-β-环糊精(SBE-β-CYD)中的任意一种。
5.根据权利要求1、2、3所述的方法,其特征在于,所述的酒精为食用级酒精;所述的水为纯净水。
6.根据权利要求1、2、3所述的方法,其特征在于,所述的干燥为真空干燥;所述真空干燥的条件为温度50℃、真空度0.2kPa。
7.根据权利要求1、2、3所述复方酸枣仁组合提取物的用途,其特征在于,按常规工艺制成片剂、胶囊剂、颗粒剂、丸剂、口服液作为制备功能性食品的用途。
8.根据权利要求1、2、3所述复方酸枣仁组合提取物的用途,其特征在于,作为制备成酒品的用途。
9.根据权利要求7所述的用途,其特征在于,所述的片剂为泡腾片、咀嚼片和口含片;所述的胶囊剂为软胶囊剂和硬胶囊剂;所述的丸剂为水泛丸、滴丸、微丸和蜜丸。
10.根据权利要求8所述的用途,其特征在于,所述的酒为白酒、葡萄酒、黄酒和啤酒。
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