CN107746834A - 用于制备普瑞巴林的方法和中间体 - Google Patents

用于制备普瑞巴林的方法和中间体 Download PDF

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Publication number
CN107746834A
CN107746834A CN201710882572.0A CN201710882572A CN107746834A CN 107746834 A CN107746834 A CN 107746834A CN 201710882572 A CN201710882572 A CN 201710882572A CN 107746834 A CN107746834 A CN 107746834A
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Chinese (zh)
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S·德巴尔热
D·T·厄德曼
P·M·奥尼尔
R·库玛
M·J·卡尔米洛维兹
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Pfizer Ireland Pharmaceuticals UC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
CN201710882572.0A 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体 Pending CN107746834A (zh)

Applications Claiming Priority (3)

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US201361805786P 2013-03-27 2013-03-27
US61/805,786 2013-03-27
CN201480018083.5A CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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CN201710882572.0A Pending CN107746834A (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体
CN201710882505.9A Pending CN107556273A (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体
CN201480018083.5A Expired - Fee Related CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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CN201480018083.5A Expired - Fee Related CN105051022B (zh) 2013-03-27 2014-03-25 用于制备普瑞巴林的方法和中间体

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US (1) US20160024540A1 (cg-RX-API-DMAC7.html)
EP (2) EP2978748B1 (cg-RX-API-DMAC7.html)
JP (1) JP2016516744A (cg-RX-API-DMAC7.html)
KR (1) KR20150121202A (cg-RX-API-DMAC7.html)
CN (3) CN107746834A (cg-RX-API-DMAC7.html)
AU (2) AU2014240833B2 (cg-RX-API-DMAC7.html)
BR (2) BR112015024859A2 (cg-RX-API-DMAC7.html)
CA (1) CA2905411A1 (cg-RX-API-DMAC7.html)
CY (1) CY1118945T1 (cg-RX-API-DMAC7.html)
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ES (1) ES2630128T3 (cg-RX-API-DMAC7.html)
HU (1) HUE034834T2 (cg-RX-API-DMAC7.html)
IL (1) IL241438A0 (cg-RX-API-DMAC7.html)
MX (1) MX2015013589A (cg-RX-API-DMAC7.html)
PL (1) PL2978748T3 (cg-RX-API-DMAC7.html)
PT (1) PT2978748T (cg-RX-API-DMAC7.html)
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Cited By (1)

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CN111004102A (zh) * 2019-12-23 2020-04-14 万华化学集团股份有限公司 一种制备光学活性香茅醛的方法及用于该方法的催化剂

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HUE036104T2 (hu) 2009-01-08 2018-06-28 Codexis Inc Transzamináz polipeptidek
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
EP3761036B1 (en) 2015-03-03 2025-11-19 ARK Diagnostics, Inc. Pregabalin immunoassays
WO2018231462A1 (en) * 2017-06-14 2018-12-20 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
BR112021000202B1 (pt) 2018-07-09 2023-03-28 Merck Sharp & Dohme Llc Métodos para síntese enzimática de nucleosídeo 4'-etinila 2-desóxi e compostos
CN118772033A (zh) * 2024-06-11 2024-10-15 中国科学院成都生物研究所 一种普瑞巴林三聚体的合成方法
CN121914996B (zh) * 2026-03-27 2026-06-23 浙江华康药业股份有限公司 一种甲酸脱氢酶突变体及其应用

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CN111004102A (zh) * 2019-12-23 2020-04-14 万华化学集团股份有限公司 一种制备光学活性香茅醛的方法及用于该方法的催化剂

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ES2630128T3 (es) 2017-08-18
PL2978748T3 (pl) 2017-09-29
SG11201506998XA (en) 2015-10-29
CN105051022B (zh) 2017-10-27
CN105051022A (zh) 2015-11-11
ZA201506798B (en) 2019-05-29
MX2015013589A (es) 2016-06-23
US20160024540A1 (en) 2016-01-28
BR122017006144A2 (pt) 2019-09-03
CN107556273A (zh) 2018-01-09
EP2978748B1 (en) 2017-05-10
EP3216863A1 (en) 2017-09-13
SI2978748T1 (sl) 2017-07-31
RU2017125261A (ru) 2019-01-31
HK1213882A1 (zh) 2016-07-15
WO2014155291A1 (en) 2014-10-02
KR20150121202A (ko) 2015-10-28
CA2905411A1 (en) 2014-10-02
JP2016516744A (ja) 2016-06-09
AU2014240833A1 (en) 2015-10-01
HUE034834T2 (en) 2018-03-28
CY1118945T1 (el) 2018-01-10
EP2978748A1 (en) 2016-02-03
AU2016203782A1 (en) 2016-06-23
BR112015024859A2 (pt) 2017-10-10
RU2015138545A (ru) 2017-05-03
AU2016203782B2 (en) 2017-06-01
IL241438A0 (en) 2015-11-30
RU2628298C2 (ru) 2017-08-15
DK2978748T3 (en) 2017-07-24
AU2014240833B2 (en) 2016-07-07
PT2978748T (pt) 2017-07-06

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Application publication date: 20180302