BR112015024859A2 - processo e intermediários para a preparação de pregabalina - Google Patents
processo e intermediários para a preparação de pregabalinaInfo
- Publication number
- BR112015024859A2 BR112015024859A2 BR112015024859A BR112015024859A BR112015024859A2 BR 112015024859 A2 BR112015024859 A2 BR 112015024859A2 BR 112015024859 A BR112015024859 A BR 112015024859A BR 112015024859 A BR112015024859 A BR 112015024859A BR 112015024859 A2 BR112015024859 A2 BR 112015024859A2
- Authority
- BR
- Brazil
- Prior art keywords
- pregabalin
- intermediates
- preparation
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122017006144A BR122017006144A2 (pt) | 2013-03-27 | 2014-03-25 | enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361805786P | 2013-03-27 | 2013-03-27 | |
| PCT/IB2014/060140 WO2014155291A1 (en) | 2013-03-27 | 2014-03-25 | Process and intermediates for the preparation of pregabalin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015024859A2 true BR112015024859A2 (pt) | 2017-10-10 |
Family
ID=50483187
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015024859A BR112015024859A2 (pt) | 2013-03-27 | 2014-03-25 | processo e intermediários para a preparação de pregabalina |
| BR122017006144A BR122017006144A2 (pt) | 2013-03-27 | 2014-03-25 | enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122017006144A BR122017006144A2 (pt) | 2013-03-27 | 2014-03-25 | enzima transaminase e processo para a fabricação de ácido (s)-3-aminometil-5-metil-hexanoico |
Country Status (21)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE036104T2 (hu) | 2009-01-08 | 2018-06-28 | Codexis Inc | Transzamináz polipeptidek |
| WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
| EP3761036B1 (en) | 2015-03-03 | 2025-11-19 | ARK Diagnostics, Inc. | Pregabalin immunoassays |
| WO2018231462A1 (en) * | 2017-06-14 | 2018-12-20 | Codexis, Inc. | Engineered transaminase polypeptides for industrial biocatalysis |
| BR112021000202B1 (pt) | 2018-07-09 | 2023-03-28 | Merck Sharp & Dohme Llc | Métodos para síntese enzimática de nucleosídeo 4'-etinila 2-desóxi e compostos |
| CN111004102B (zh) * | 2019-12-23 | 2022-11-04 | 万华化学集团股份有限公司 | 一种制备光学活性香茅醛的方法及用于该方法的催化剂 |
| CN118772033A (zh) * | 2024-06-11 | 2024-10-15 | 中国科学院成都生物研究所 | 一种普瑞巴林三聚体的合成方法 |
| CN121914996B (zh) * | 2026-03-27 | 2026-06-23 | 浙江华康药业股份有限公司 | 一种甲酸脱氢酶突变体及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB834100A (en) | 1957-10-26 | 1960-05-04 | Eastman Kodak Co | Improvements in the preparation of mixed aldols |
| US4239636A (en) * | 1978-10-23 | 1980-12-16 | Exxon Research & Engineering Co. | Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| JPH06107597A (ja) * | 1992-03-12 | 1994-04-19 | Noguchi Kenkyusho | （Ｒ）−α−ヒドロキシ−β，γ−不飽和エステルの製造法 |
| US5268387A (en) * | 1992-04-24 | 1993-12-07 | Allergan, Inc. | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss |
| CA2236939A1 (en) * | 1995-11-07 | 1997-05-15 | E. John Deviny | Initiator system and adhesive composition made therewith |
| EP0934061B3 (en) | 1996-07-24 | 2015-01-21 | Warner-Lambert Company LLC | Isobutylgaba and its derivatives for the treatment of pain |
| SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
| MX2007012606A (es) * | 2005-04-11 | 2008-01-11 | Teva Pharma | Proceso para elaborar (s)-pregabalina. |
| RU2008109031A (ru) * | 2005-08-11 | 2009-09-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы муковисцидозного трансмембранного регулятора проводимости |
| WO2008127646A2 (en) * | 2007-04-11 | 2008-10-23 | Dsm Ip Assets B.V. | Transaminase-based processes for preparation of pregabalin |
| KR100846419B1 (ko) * | 2007-08-10 | 2008-07-15 | 한국과학기술원 | 프레가발린의 신규한 제조 방법 |
| CN101362696A (zh) * | 2008-09-27 | 2009-02-11 | 开原亨泰精细化工厂 | 3-氨甲基-5-甲基己酸即混旋普瑞巴林的制备新方法 |
| HUE036104T2 (hu) * | 2009-01-08 | 2018-06-28 | Codexis Inc | Transzamináz polipeptidek |
| WO2011086565A1 (en) * | 2010-01-15 | 2011-07-21 | Lupin Limited | Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids |
-
2014
- 2014-03-25 BR BR112015024859A patent/BR112015024859A2/pt not_active IP Right Cessation
- 2014-03-25 CN CN201710882572.0A patent/CN107746834A/zh active Pending
- 2014-03-25 RU RU2017125261A patent/RU2017125261A/ru not_active Application Discontinuation
- 2014-03-25 AU AU2014240833A patent/AU2014240833B2/en not_active Ceased
- 2014-03-25 MX MX2015013589A patent/MX2015013589A/es unknown
- 2014-03-25 CN CN201710882505.9A patent/CN107556273A/zh active Pending
- 2014-03-25 SI SI201430236A patent/SI2978748T1/sl unknown
- 2014-03-25 CN CN201480018083.5A patent/CN105051022B/zh not_active Expired - Fee Related
- 2014-03-25 KR KR1020157026688A patent/KR20150121202A/ko not_active Abandoned
- 2014-03-25 BR BR122017006144A patent/BR122017006144A2/pt not_active IP Right Cessation
- 2014-03-25 EP EP14717080.7A patent/EP2978748B1/en not_active Not-in-force
- 2014-03-25 RU RU2015138545A patent/RU2628298C2/ru not_active IP Right Cessation
- 2014-03-25 DK DK14717080.7T patent/DK2978748T3/en active
- 2014-03-25 PL PL14717080T patent/PL2978748T3/pl unknown
- 2014-03-25 ES ES14717080.7T patent/ES2630128T3/es active Active
- 2014-03-25 CA CA2905411A patent/CA2905411A1/en not_active Abandoned
- 2014-03-25 JP JP2016504807A patent/JP2016516744A/ja active Pending
- 2014-03-25 US US14/775,979 patent/US20160024540A1/en not_active Abandoned
- 2014-03-25 SG SG11201506998XA patent/SG11201506998XA/en unknown
- 2014-03-25 HU HUE14717080A patent/HUE034834T2/en unknown
- 2014-03-25 EP EP17162642.7A patent/EP3216863A1/en not_active Withdrawn
- 2014-03-25 PT PT147170807T patent/PT2978748T/pt unknown
- 2014-03-25 WO PCT/IB2014/060140 patent/WO2014155291A1/en not_active Ceased
-
2015
- 2015-09-10 IL IL241438A patent/IL241438A0/en unknown
- 2015-09-14 ZA ZA2015/06798A patent/ZA201506798B/en unknown
-
2016
- 2016-06-07 AU AU2016203782A patent/AU2016203782B2/en not_active Ceased
-
2017
- 2017-06-13 CY CY20171100622T patent/CY1118945T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2630128T3 (es) | 2017-08-18 |
| PL2978748T3 (pl) | 2017-09-29 |
| SG11201506998XA (en) | 2015-10-29 |
| CN105051022B (zh) | 2017-10-27 |
| CN105051022A (zh) | 2015-11-11 |
| ZA201506798B (en) | 2019-05-29 |
| MX2015013589A (es) | 2016-06-23 |
| US20160024540A1 (en) | 2016-01-28 |
| CN107746834A (zh) | 2018-03-02 |
| BR122017006144A2 (pt) | 2019-09-03 |
| CN107556273A (zh) | 2018-01-09 |
| EP2978748B1 (en) | 2017-05-10 |
| EP3216863A1 (en) | 2017-09-13 |
| SI2978748T1 (sl) | 2017-07-31 |
| RU2017125261A (ru) | 2019-01-31 |
| HK1213882A1 (zh) | 2016-07-15 |
| WO2014155291A1 (en) | 2014-10-02 |
| KR20150121202A (ko) | 2015-10-28 |
| CA2905411A1 (en) | 2014-10-02 |
| JP2016516744A (ja) | 2016-06-09 |
| AU2014240833A1 (en) | 2015-10-01 |
| HUE034834T2 (en) | 2018-03-28 |
| CY1118945T1 (el) | 2018-01-10 |
| EP2978748A1 (en) | 2016-02-03 |
| AU2016203782A1 (en) | 2016-06-23 |
| RU2015138545A (ru) | 2017-05-03 |
| AU2016203782B2 (en) | 2017-06-01 |
| IL241438A0 (en) | 2015-11-30 |
| RU2628298C2 (ru) | 2017-08-15 |
| DK2978748T3 (en) | 2017-07-24 |
| AU2014240833B2 (en) | 2016-07-07 |
| PT2978748T (pt) | 2017-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2559 DE 21/01/2020. |