CN107624073B - 用于在微反应器中连续病毒灭活的方法 - Google Patents

用于在微反应器中连续病毒灭活的方法 Download PDF

Info

Publication number
CN107624073B
CN107624073B CN201680024485.5A CN201680024485A CN107624073B CN 107624073 B CN107624073 B CN 107624073B CN 201680024485 A CN201680024485 A CN 201680024485A CN 107624073 B CN107624073 B CN 107624073B
Authority
CN
China
Prior art keywords
product stream
reactor
inactivated
virus inactivation
inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201680024485.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN107624073A (zh
Inventor
P.施万
A.韦斯特
M.洛贝丹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN107624073A publication Critical patent/CN107624073A/zh
Application granted granted Critical
Publication of CN107624073B publication Critical patent/CN107624073B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0094—Gaseous substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680024485.5A 2015-04-28 2016-04-25 用于在微反应器中连续病毒灭活的方法 Expired - Fee Related CN107624073B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15165505.7A EP3088006A1 (de) 2015-04-28 2015-04-28 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
EP15165505.7 2015-04-28
PCT/EP2016/059169 WO2016173982A1 (de) 2015-04-28 2016-04-25 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor

Publications (2)

Publication Number Publication Date
CN107624073A CN107624073A (zh) 2018-01-23
CN107624073B true CN107624073B (zh) 2020-05-22

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680024485.5A Expired - Fee Related CN107624073B (zh) 2015-04-28 2016-04-25 用于在微反应器中连续病毒灭活的方法

Country Status (20)

Country Link
US (1) US10434201B2 (enExample)
EP (2) EP3088006A1 (enExample)
JP (1) JP6851981B2 (enExample)
KR (1) KR20170140219A (enExample)
CN (1) CN107624073B (enExample)
AR (1) AR104440A1 (enExample)
AU (1) AU2016254582C1 (enExample)
BR (1) BR112017023246B1 (enExample)
CA (1) CA2983884A1 (enExample)
DK (1) DK3288596T3 (enExample)
ES (1) ES2720034T3 (enExample)
IL (1) IL255137B (enExample)
MX (1) MX380149B (enExample)
RU (1) RU2719363C2 (enExample)
SA (1) SA517390240B1 (enExample)
SG (1) SG11201708749WA (enExample)
TR (1) TR201904906T4 (enExample)
TW (1) TWI695070B (enExample)
WO (1) WO2016173982A1 (enExample)
ZA (1) ZA201708043B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3621715A4 (en) * 2017-05-11 2021-01-27 EMD Millipore Corporation MECHANICAL PROCEDURE FOR MAINTAINING TIGHT DISTRIBUTION OF DWELL TIME IN CONTINUOUS FLOW SYSTEMS
CA3062519A1 (en) * 2017-05-11 2018-11-15 Emd Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems using solid material packet interfaces
US20190022654A1 (en) 2017-07-10 2019-01-24 Baxalta Incorporated Method for incubating liquids
US12435303B2 (en) 2018-10-08 2025-10-07 Boehringer Ingelheim International Gmbh Continuous flow reactor for low pH viral inactivation
DE102018009597A1 (de) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
CN114247395B (zh) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 一种中空纤维膜式微通道反应器及应用
GB2631765A (en) 2023-07-13 2025-01-15 Univ Cranfield Viral inactivation reactor and method
CN117298304B (zh) * 2023-09-18 2025-08-22 浙江大学 一种组装式连续病毒灭活装置及其设计方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629135B1 (en) * 1992-03-02 2000-07-26 Bioeng, Inc. Viral inactivation method
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
CN1786018A (zh) * 2005-12-12 2006-06-14 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
CN1822893A (zh) * 2003-05-16 2006-08-23 万罗赛斯公司 使用微通道加工技术产生乳状液的方法
CN101065154A (zh) * 2004-08-24 2007-10-31 巴克斯特国际公司 在生物液体中灭活微生物的方法、流通式反应器以及控制光辐照总剂量从而有效灭活间歇反应器中微生物的方法
CN101772821A (zh) * 2007-08-10 2010-07-07 株式会社日本光电科技 短波长紫外线放电灯和紫外线照射处理装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69707288T2 (de) 1996-07-15 2002-07-18 Calcitech Ltd., Hamilton Herstellung von pulvern
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
AU2002229545B2 (en) 2000-11-13 2007-08-30 Bayer Aktiengesellschaft Method of inactivating microorganisms in a fluid using ultraviolet radiation
DE10056096A1 (de) 2000-11-13 2002-06-13 Bayer Ag Vorrichtung zur Bestrahlung von Flüssigkeiten
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
EP1633463B1 (en) * 2003-05-16 2007-10-24 Velocys Inc. Process for forming an emulsion using microchannel process technology
JP5885901B2 (ja) * 2004-09-09 2016-03-16 アンスティテュート キュリー マイクロチャネルまたは他のマイクロ容器中でパケットを操作するためのデバイス
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
NZ592097A (en) * 2008-10-20 2013-01-25 Abbott Lab Viral inactivation during purification of il-12 and il-18 antibodies
US8956566B2 (en) * 2012-03-12 2015-02-17 Pure Biosolutions, Llc System and method for virus inactivation
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629135B1 (en) * 1992-03-02 2000-07-26 Bioeng, Inc. Viral inactivation method
CN1822893A (zh) * 2003-05-16 2006-08-23 万罗赛斯公司 使用微通道加工技术产生乳状液的方法
CN101065154A (zh) * 2004-08-24 2007-10-31 巴克斯特国际公司 在生物液体中灭活微生物的方法、流通式反应器以及控制光辐照总剂量从而有效灭活间歇反应器中微生物的方法
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
CN101084061A (zh) * 2004-10-01 2007-12-05 万罗赛斯公司 使用微通道工艺技术的多相混合方法
CN1786018A (zh) * 2005-12-12 2006-06-14 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
CN101772821A (zh) * 2007-08-10 2010-07-07 株式会社日本光电科技 短波长紫外线放电灯和紫外线照射处理装置

Also Published As

Publication number Publication date
TR201904906T4 (tr) 2019-05-21
EP3288596B1 (de) 2019-03-20
AR104440A1 (es) 2017-07-19
ES2720034T3 (es) 2019-07-17
US20190117803A1 (en) 2019-04-25
EP3288596A1 (de) 2018-03-07
DK3288596T3 (da) 2019-05-06
MX2017013893A (es) 2018-03-15
CN107624073A (zh) 2018-01-23
BR112017023246B1 (pt) 2021-09-08
MX380149B (es) 2025-03-12
JP2018517455A (ja) 2018-07-05
AU2016254582C1 (en) 2020-04-30
BR112017023246A2 (pt) 2020-05-19
SG11201708749WA (en) 2017-11-29
JP6851981B2 (ja) 2021-03-31
RU2017141168A3 (enExample) 2019-11-14
TWI695070B (zh) 2020-06-01
TW201702377A (zh) 2017-01-16
KR20170140219A (ko) 2017-12-20
HK1249867A1 (zh) 2018-11-16
AU2016254582A1 (en) 2017-11-09
IL255137B (en) 2020-10-29
WO2016173982A1 (de) 2016-11-03
IL255137A0 (en) 2017-12-31
SA517390240B1 (ar) 2021-03-01
EP3088006A1 (de) 2016-11-02
ZA201708043B (en) 2020-01-29
CA2983884A1 (en) 2016-11-03
RU2719363C2 (ru) 2020-04-17
US10434201B2 (en) 2019-10-08
AU2016254582B2 (en) 2020-01-30
RU2017141168A (ru) 2019-05-28

Similar Documents

Publication Publication Date Title
CN107624073B (zh) 用于在微反应器中连续病毒灭活的方法
CA2941901C (en) Device and method for continuous virus inactivation
TWI698529B (zh) 連續流動系統中保持窄滯留時間分布的方法
CN110267724A (zh) 连续加工保健产品的方法中的脱气
EP3723500B1 (en) Unit operation device and use thereof
TWI686471B (zh) 流體通道及連續流動系統中保持窄滯留時間分布的機械方法
HK1249867B (zh) 用於在微反应器中连续病毒灭活的方法
CN112512657A (zh) 将至少一种经脱气的药物产品填充至容器的方法及填充药物产品的装置
HK40046697A (en) Method of filling at least one degassed drug product into containers and drug product filling device
NZ723484B2 (en) Device and method for continuous virus inactivation
HK40007874A (en) Degassing in methods for continuous processing of a healthcare product

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1249867

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20200522