RU2719363C2 - Способ непрерывной вирусной инактивации в микрореакторе - Google Patents
Способ непрерывной вирусной инактивации в микрореакторе Download PDFInfo
- Publication number
- RU2719363C2 RU2719363C2 RU2017141168A RU2017141168A RU2719363C2 RU 2719363 C2 RU2719363 C2 RU 2719363C2 RU 2017141168 A RU2017141168 A RU 2017141168A RU 2017141168 A RU2017141168 A RU 2017141168A RU 2719363 C2 RU2719363 C2 RU 2719363C2
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- Prior art keywords
- product stream
- product
- viral inactivation
- flow
- inactivated
- Prior art date
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- 238000000926 separation method Methods 0.000 claims description 20
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
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- A—HUMAN NECESSITIES
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0094—Gaseous substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15165505.7A EP3088006A1 (de) | 2015-04-28 | 2015-04-28 | Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor |
| EP15165505.7 | 2015-04-28 | ||
| PCT/EP2016/059169 WO2016173982A1 (de) | 2015-04-28 | 2016-04-25 | Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017141168A RU2017141168A (ru) | 2019-05-28 |
| RU2017141168A3 RU2017141168A3 (enExample) | 2019-11-14 |
| RU2719363C2 true RU2719363C2 (ru) | 2020-04-17 |
Family
ID=53016520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017141168A RU2719363C2 (ru) | 2015-04-28 | 2016-04-25 | Способ непрерывной вирусной инактивации в микрореакторе |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10434201B2 (enExample) |
| EP (2) | EP3088006A1 (enExample) |
| JP (1) | JP6851981B2 (enExample) |
| KR (1) | KR20170140219A (enExample) |
| CN (1) | CN107624073B (enExample) |
| AR (1) | AR104440A1 (enExample) |
| AU (1) | AU2016254582C1 (enExample) |
| BR (1) | BR112017023246B1 (enExample) |
| CA (1) | CA2983884A1 (enExample) |
| DK (1) | DK3288596T3 (enExample) |
| ES (1) | ES2720034T3 (enExample) |
| IL (1) | IL255137B (enExample) |
| MX (1) | MX380149B (enExample) |
| RU (1) | RU2719363C2 (enExample) |
| SA (1) | SA517390240B1 (enExample) |
| SG (1) | SG11201708749WA (enExample) |
| TR (1) | TR201904906T4 (enExample) |
| TW (1) | TWI695070B (enExample) |
| WO (1) | WO2016173982A1 (enExample) |
| ZA (1) | ZA201708043B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102286411B1 (ko) * | 2017-05-11 | 2021-08-05 | 이엠디 밀리포어 코포레이션 | 연속 유동 시스템에서 좁은 체류 시간 분포를 유지하기 위한 방법 |
| US11732003B2 (en) | 2017-05-11 | 2023-08-22 | Emd Millipore Corporation | Mechanical method of maintaining narrow residence time distributions in continuous flow systems |
| EP3651811A1 (en) | 2017-07-10 | 2020-05-20 | Baxalta Incorporated | Method for incubating liquids and inactivating viruses |
| CA3115253A1 (en) * | 2018-10-08 | 2020-04-16 | Boehringer Ingelheim International Gmbh | A novel continuous flow reactor for low ph viral inactivation |
| DE102018009597A1 (de) | 2018-12-07 | 2020-06-10 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids |
| CN114247395B (zh) * | 2020-09-23 | 2023-04-25 | 中国科学院大连化学物理研究所 | 一种中空纤维膜式微通道反应器及应用 |
| GB2631765A (en) | 2023-07-13 | 2025-01-15 | Univ Cranfield | Viral inactivation reactor and method |
| CN117298304B (zh) * | 2023-09-18 | 2025-08-22 | 浙江大学 | 一种组装式连续病毒灭活装置及其设计方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004103539A2 (en) * | 2003-05-16 | 2004-12-02 | Velocys Inc. | Process for forming an emulsion using microchannel process technology |
| WO2006039568A1 (en) * | 2004-10-01 | 2006-04-13 | Velocys Inc. | Multiphase mixing process using microchannel process technology |
| US20090269250A1 (en) * | 2008-04-23 | 2009-10-29 | Mfic Corporation | Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems |
| WO2010048192A2 (en) * | 2008-10-20 | 2010-04-29 | Abbott Laboratories | Viral inactivation during purification of antibodies |
| US20130236358A1 (en) * | 2012-03-12 | 2013-09-12 | Peter W. Latham | System and method for virus inactivation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4260877B2 (ja) * | 1992-03-02 | 2009-04-30 | バイオエング・インコーポレーテッド | ウイルスの不活性化方法 |
| EP0912238B1 (en) | 1996-07-15 | 2001-10-10 | CalCiTech Ltd. | Production of powders |
| GB2359765B (en) * | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
| DE10056096A1 (de) | 2000-11-13 | 2002-06-13 | Bayer Ag | Vorrichtung zur Bestrahlung von Flüssigkeiten |
| EP1337280B1 (en) | 2000-11-13 | 2013-09-04 | Bayer Intellectual Property GmbH | Method of inactivating microorganisms in a fluid using ultraviolet radiation |
| DE10312765A1 (de) * | 2003-03-21 | 2004-09-30 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung |
| US7485671B2 (en) * | 2003-05-16 | 2009-02-03 | Velocys, Inc. | Process for forming an emulsion using microchannel process technology |
| US7993580B2 (en) * | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| CN102513170B (zh) * | 2004-09-09 | 2015-03-25 | 居里研究所 | 用于在微容器特别是微通道中操纵小包的装置 |
| CN1786018B (zh) * | 2005-12-12 | 2011-06-22 | 天津协和生物科技发展有限公司 | 高纯度血红蛋白的分离纯化与病毒灭活工艺 |
| DE102006019242A1 (de) | 2006-04-21 | 2007-10-25 | Bayer Technology Services Gmbh | Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor |
| KR20100057597A (ko) * | 2007-08-10 | 2010-05-31 | 가부시키가이샤 니혼포토사이언스 | 단파장 자외선 방전등과 자외선 조사 처리 장치 |
| EP2918294A1 (de) * | 2014-03-11 | 2015-09-16 | Bayer Technology Services GmbH | Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung |
-
2015
- 2015-04-28 EP EP15165505.7A patent/EP3088006A1/de not_active Withdrawn
-
2016
- 2016-04-25 TR TR2019/04906T patent/TR201904906T4/tr unknown
- 2016-04-25 ES ES16718357T patent/ES2720034T3/es active Active
- 2016-04-25 MX MX2017013893A patent/MX380149B/es unknown
- 2016-04-25 DK DK16718357.3T patent/DK3288596T3/da active
- 2016-04-25 JP JP2017556546A patent/JP6851981B2/ja not_active Expired - Fee Related
- 2016-04-25 KR KR1020177030712A patent/KR20170140219A/ko not_active Ceased
- 2016-04-25 RU RU2017141168A patent/RU2719363C2/ru active
- 2016-04-25 SG SG11201708749WA patent/SG11201708749WA/en unknown
- 2016-04-25 WO PCT/EP2016/059169 patent/WO2016173982A1/de not_active Ceased
- 2016-04-25 CN CN201680024485.5A patent/CN107624073B/zh not_active Expired - Fee Related
- 2016-04-25 AU AU2016254582A patent/AU2016254582C1/en not_active Ceased
- 2016-04-25 US US15/569,635 patent/US10434201B2/en not_active Expired - Fee Related
- 2016-04-25 EP EP16718357.3A patent/EP3288596B1/de active Active
- 2016-04-25 CA CA2983884A patent/CA2983884A1/en not_active Abandoned
- 2016-04-25 BR BR112017023246-4A patent/BR112017023246B1/pt not_active IP Right Cessation
- 2016-04-26 TW TW105112897A patent/TWI695070B/zh not_active IP Right Cessation
- 2016-04-28 AR ARP160101209A patent/AR104440A1/es active IP Right Grant
-
2017
- 2017-10-19 IL IL255137A patent/IL255137B/en active IP Right Grant
- 2017-10-26 SA SA517390240A patent/SA517390240B1/ar unknown
- 2017-11-27 ZA ZA2017/08043A patent/ZA201708043B/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004103539A2 (en) * | 2003-05-16 | 2004-12-02 | Velocys Inc. | Process for forming an emulsion using microchannel process technology |
| WO2006039568A1 (en) * | 2004-10-01 | 2006-04-13 | Velocys Inc. | Multiphase mixing process using microchannel process technology |
| US20090269250A1 (en) * | 2008-04-23 | 2009-10-29 | Mfic Corporation | Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems |
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