AU2016254582C1 - Method for continuous virus inactivation in a microreactor - Google Patents

Method for continuous virus inactivation in a microreactor Download PDF

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Publication number
AU2016254582C1
AU2016254582C1 AU2016254582A AU2016254582A AU2016254582C1 AU 2016254582 C1 AU2016254582 C1 AU 2016254582C1 AU 2016254582 A AU2016254582 A AU 2016254582A AU 2016254582 A AU2016254582 A AU 2016254582A AU 2016254582 C1 AU2016254582 C1 AU 2016254582C1
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AU
Australia
Prior art keywords
product stream
virus
inactivated
reactor
virus inactivation
Prior art date
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Ceased
Application number
AU2016254582A
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English (en)
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AU2016254582A1 (en
AU2016254582B2 (en
Inventor
Martin Lobedann
Peter Schwan
Andrea VESTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
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Publication of AU2016254582A1 publication Critical patent/AU2016254582A1/en
Application granted granted Critical
Publication of AU2016254582B2 publication Critical patent/AU2016254582B2/en
Publication of AU2016254582C1 publication Critical patent/AU2016254582C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet [UV] radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2016254582A 2015-04-28 2016-04-25 Method for continuous virus inactivation in a microreactor Ceased AU2016254582C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15165505.7A EP3088006A1 (de) 2015-04-28 2015-04-28 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
EP15165505.7 2015-04-28
PCT/EP2016/059169 WO2016173982A1 (de) 2015-04-28 2016-04-25 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor

Publications (3)

Publication Number Publication Date
AU2016254582A1 AU2016254582A1 (en) 2017-11-09
AU2016254582B2 AU2016254582B2 (en) 2020-01-30
AU2016254582C1 true AU2016254582C1 (en) 2020-04-30

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016254582A Ceased AU2016254582C1 (en) 2015-04-28 2016-04-25 Method for continuous virus inactivation in a microreactor

Country Status (20)

Country Link
US (1) US10434201B2 (enExample)
EP (2) EP3088006A1 (enExample)
JP (1) JP6851981B2 (enExample)
KR (1) KR20170140219A (enExample)
CN (1) CN107624073B (enExample)
AR (1) AR104440A1 (enExample)
AU (1) AU2016254582C1 (enExample)
BR (1) BR112017023246B1 (enExample)
CA (1) CA2983884A1 (enExample)
DK (1) DK3288596T3 (enExample)
ES (1) ES2720034T3 (enExample)
IL (1) IL255137B (enExample)
MX (1) MX380149B (enExample)
RU (1) RU2719363C2 (enExample)
SA (1) SA517390240B1 (enExample)
SG (1) SG11201708749WA (enExample)
TR (1) TR201904906T4 (enExample)
TW (1) TWI695070B (enExample)
WO (1) WO2016173982A1 (enExample)
ZA (1) ZA201708043B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11732003B2 (en) 2017-05-11 2023-08-22 Emd Millipore Corporation Mechanical method of maintaining narrow residence time distributions in continuous flow systems
WO2018208448A1 (en) * 2017-05-11 2018-11-15 Emd Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems
CN111050809B (zh) 2017-07-10 2021-12-24 武田药品工业株式会社 孵育液体和灭活病毒的方法
WO2020076681A1 (en) * 2018-10-08 2020-04-16 Boehringer Ingelheim International Gmbh A novel continuous flow reactor for low ph viral inactivation
DE102018009597A1 (de) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
CN114247395B (zh) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 一种中空纤维膜式微通道反应器及应用
GB2631765A (en) 2023-07-13 2025-01-15 Univ Cranfield Viral inactivation reactor and method
CN117298304B (zh) * 2023-09-18 2025-08-22 浙江大学 一种组装式连续病毒灭活装置及其设计方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103539A2 (en) * 2003-05-16 2004-12-02 Velocys Inc. Process for forming an emulsion using microchannel process technology
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
US20090269250A1 (en) * 2008-04-23 2009-10-29 Mfic Corporation Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE194921T1 (de) * 1992-03-02 2000-08-15 Bioeng Inc Verfahren zur inaktivierung von viren
EP0912238B1 (en) 1996-07-15 2001-10-10 CalCiTech Ltd. Production of powders
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
DE10056096A1 (de) 2000-11-13 2002-06-13 Bayer Ag Vorrichtung zur Bestrahlung von Flüssigkeiten
AU2954502A (en) 2000-11-13 2002-05-21 Bayer Ag Method of inactivating microorganisms in a fluid using ultraviolet radiation
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
WO2006027757A2 (en) * 2004-09-09 2006-03-16 Institut Curie Microfluidic device using a collinear electric field
CN1786018B (zh) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
KR20100057597A (ko) * 2007-08-10 2010-05-31 가부시키가이샤 니혼포토사이언스 단파장 자외선 방전등과 자외선 조사 처리 장치
TW201028433A (en) * 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
US8956566B2 (en) * 2012-03-12 2015-02-17 Pure Biosolutions, Llc System and method for virus inactivation
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103539A2 (en) * 2003-05-16 2004-12-02 Velocys Inc. Process for forming an emulsion using microchannel process technology
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
US20090269250A1 (en) * 2008-04-23 2009-10-29 Mfic Corporation Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems

Also Published As

Publication number Publication date
JP2018517455A (ja) 2018-07-05
AU2016254582A1 (en) 2017-11-09
CA2983884A1 (en) 2016-11-03
JP6851981B2 (ja) 2021-03-31
US10434201B2 (en) 2019-10-08
AR104440A1 (es) 2017-07-19
CN107624073A (zh) 2018-01-23
EP3088006A1 (de) 2016-11-02
MX2017013893A (es) 2018-03-15
MX380149B (es) 2025-03-12
BR112017023246A2 (pt) 2020-05-19
BR112017023246B1 (pt) 2021-09-08
SG11201708749WA (en) 2017-11-29
ZA201708043B (en) 2020-01-29
HK1249867A1 (zh) 2018-11-16
WO2016173982A1 (de) 2016-11-03
EP3288596A1 (de) 2018-03-07
KR20170140219A (ko) 2017-12-20
RU2017141168A (ru) 2019-05-28
RU2719363C2 (ru) 2020-04-17
RU2017141168A3 (enExample) 2019-11-14
IL255137B (en) 2020-10-29
DK3288596T3 (da) 2019-05-06
SA517390240B1 (ar) 2021-03-01
ES2720034T3 (es) 2019-07-17
TWI695070B (zh) 2020-06-01
TR201904906T4 (tr) 2019-05-21
AU2016254582B2 (en) 2020-01-30
TW201702377A (zh) 2017-01-16
IL255137A0 (en) 2017-12-31
EP3288596B1 (de) 2019-03-20
US20190117803A1 (en) 2019-04-25
CN107624073B (zh) 2020-05-22

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Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 22 JAN 2020

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 22 JAN 2020

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired