TR201904906T4 - Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. - Google Patents
Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. Download PDFInfo
- Publication number
- TR201904906T4 TR201904906T4 TR2019/04906T TR201904906T TR201904906T4 TR 201904906 T4 TR201904906 T4 TR 201904906T4 TR 2019/04906 T TR2019/04906 T TR 2019/04906T TR 201904906 T TR201904906 T TR 201904906T TR 201904906 T4 TR201904906 T4 TR 201904906T4
- Authority
- TR
- Turkey
- Prior art keywords
- virus inactivation
- microreactor
- product stream
- continuous virus
- continuous
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 230000002779 inactivation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000014759 maintenance of location Effects 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0094—Gaseous substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Buluş, sürekli virüs inaktivasyonuna yönelik bir yöntem sağlar. Ürün akışı, ürün akışı ile karışmayan bir ayırma ortamının eklenmesi yoluyla bölünür ve bölünen ürün akışı, gerekli retansiyon süresi boyunca virüsleri inaktive eden koşullar altında retansiyon alanı olarak bir reaktöre (1) aktarılır.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15165505.7A EP3088006A1 (de) | 2015-04-28 | 2015-04-28 | Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201904906T4 true TR201904906T4 (tr) | 2019-05-21 |
Family
ID=53016520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/04906T TR201904906T4 (tr) | 2015-04-28 | 2016-04-25 | Bir mikroreaktörde sürekli virüs inaktivasyonuna yönelik yöntem. |
Country Status (21)
Country | Link |
---|---|
US (1) | US10434201B2 (tr) |
EP (2) | EP3088006A1 (tr) |
JP (1) | JP6851981B2 (tr) |
KR (1) | KR20170140219A (tr) |
CN (1) | CN107624073B (tr) |
AR (1) | AR104440A1 (tr) |
AU (1) | AU2016254582C1 (tr) |
BR (1) | BR112017023246B1 (tr) |
CA (1) | CA2983884A1 (tr) |
DK (1) | DK3288596T3 (tr) |
ES (1) | ES2720034T3 (tr) |
HK (1) | HK1249867A1 (tr) |
IL (1) | IL255137B (tr) |
MX (1) | MX2017013893A (tr) |
RU (1) | RU2719363C2 (tr) |
SA (1) | SA517390240B1 (tr) |
SG (1) | SG11201708749WA (tr) |
TR (1) | TR201904906T4 (tr) |
TW (1) | TWI695070B (tr) |
WO (1) | WO2016173982A1 (tr) |
ZA (1) | ZA201708043B (tr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018208447A1 (en) | 2017-05-11 | 2018-11-15 | Emd Millipore Corporation | Mechanical method of maintaining narrow residence time distributions in continuous flow systems |
US11547957B2 (en) | 2017-05-11 | 2023-01-10 | Emd Millipore Corporation | Method of maintaining narrow residence time distributions in continuous flow systems |
SG11202000269PA (en) | 2017-07-10 | 2020-02-27 | Baxalta Inc | Method for incubating liquids and inactivating viruses |
KR20210073554A (ko) * | 2018-10-08 | 2021-06-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 저 pH 바이러스 비활성화를 위한 새로운 연속 유동 반응기 |
DE102018009597A1 (de) | 2018-12-07 | 2020-06-10 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids |
CN114247395B (zh) * | 2020-09-23 | 2023-04-25 | 中国科学院大连化学物理研究所 | 一种中空纤维膜式微通道反应器及应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0629135B1 (en) * | 1992-03-02 | 2000-07-26 | Bioeng, Inc. | Viral inactivation method |
AU4114397A (en) | 1996-07-15 | 1998-02-09 | Kemgas Limited | Production of powders |
GB2359765B (en) * | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
DE10056096A1 (de) | 2000-11-13 | 2002-06-13 | Bayer Ag | Vorrichtung zur Bestrahlung von Flüssigkeiten |
CA2428332C (en) | 2000-11-13 | 2010-05-25 | Bayer Aktiengesellschaft | Method of inactivating microorganisms in a fluid using ultraviolet radiation |
DE10312765A1 (de) * | 2003-03-21 | 2004-09-30 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung |
US7485671B2 (en) * | 2003-05-16 | 2009-02-03 | Velocys, Inc. | Process for forming an emulsion using microchannel process technology |
WO2004103539A2 (en) * | 2003-05-16 | 2004-12-02 | Velocys Inc. | Process for forming an emulsion using microchannel process technology |
US7993580B2 (en) * | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
ES2784184T3 (es) * | 2004-09-09 | 2020-09-23 | Inst Curie | Dispositivo microfluídico que utiliza un campo eléctrico colinear |
US7622509B2 (en) * | 2004-10-01 | 2009-11-24 | Velocys, Inc. | Multiphase mixing process using microchannel process technology |
CN1786018B (zh) * | 2005-12-12 | 2011-06-22 | 天津协和生物科技发展有限公司 | 高纯度血红蛋白的分离纯化与病毒灭活工艺 |
DE102006019242A1 (de) | 2006-04-21 | 2007-10-25 | Bayer Technology Services Gmbh | Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor |
KR20100057597A (ko) * | 2007-08-10 | 2010-05-31 | 가부시키가이샤 니혼포토사이언스 | 단파장 자외선 방전등과 자외선 조사 처리 장치 |
US8187554B2 (en) * | 2008-04-23 | 2012-05-29 | Microfluidics International Corporation | Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems |
AU2009307737B2 (en) * | 2008-10-20 | 2015-07-23 | Abbvie Inc. | Viral inactivation during purification of antibodies |
US8956566B2 (en) * | 2012-03-12 | 2015-02-17 | Pure Biosolutions, Llc | System and method for virus inactivation |
EP2918294A1 (de) * | 2014-03-11 | 2015-09-16 | Bayer Technology Services GmbH | Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung |
-
2015
- 2015-04-28 EP EP15165505.7A patent/EP3088006A1/de not_active Withdrawn
-
2016
- 2016-04-25 MX MX2017013893A patent/MX2017013893A/es unknown
- 2016-04-25 AU AU2016254582A patent/AU2016254582C1/en not_active Ceased
- 2016-04-25 JP JP2017556546A patent/JP6851981B2/ja active Active
- 2016-04-25 US US15/569,635 patent/US10434201B2/en not_active Expired - Fee Related
- 2016-04-25 SG SG11201708749WA patent/SG11201708749WA/en unknown
- 2016-04-25 WO PCT/EP2016/059169 patent/WO2016173982A1/de active Application Filing
- 2016-04-25 CN CN201680024485.5A patent/CN107624073B/zh not_active Expired - Fee Related
- 2016-04-25 BR BR112017023246-4A patent/BR112017023246B1/pt not_active IP Right Cessation
- 2016-04-25 TR TR2019/04906T patent/TR201904906T4/tr unknown
- 2016-04-25 DK DK16718357.3T patent/DK3288596T3/da active
- 2016-04-25 RU RU2017141168A patent/RU2719363C2/ru active
- 2016-04-25 CA CA2983884A patent/CA2983884A1/en not_active Abandoned
- 2016-04-25 EP EP16718357.3A patent/EP3288596B1/de active Active
- 2016-04-25 ES ES16718357T patent/ES2720034T3/es active Active
- 2016-04-25 KR KR1020177030712A patent/KR20170140219A/ko not_active Application Discontinuation
- 2016-04-26 TW TW105112897A patent/TWI695070B/zh not_active IP Right Cessation
- 2016-04-28 AR ARP160101209A patent/AR104440A1/es active IP Right Grant
-
2017
- 2017-10-19 IL IL255137A patent/IL255137B/en active IP Right Grant
- 2017-10-26 SA SA517390240A patent/SA517390240B1/ar unknown
- 2017-11-27 ZA ZA2017/08043A patent/ZA201708043B/en unknown
-
2018
- 2018-07-19 HK HK18109332.8A patent/HK1249867A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN107624073B (zh) | 2020-05-22 |
RU2017141168A (ru) | 2019-05-28 |
HK1249867A1 (zh) | 2018-11-16 |
EP3288596A1 (de) | 2018-03-07 |
TW201702377A (zh) | 2017-01-16 |
MX2017013893A (es) | 2018-03-15 |
IL255137A0 (en) | 2017-12-31 |
US20190117803A1 (en) | 2019-04-25 |
DK3288596T3 (da) | 2019-05-06 |
RU2719363C2 (ru) | 2020-04-17 |
AU2016254582C1 (en) | 2020-04-30 |
JP6851981B2 (ja) | 2021-03-31 |
SG11201708749WA (en) | 2017-11-29 |
ES2720034T3 (es) | 2019-07-17 |
IL255137B (en) | 2020-10-29 |
WO2016173982A1 (de) | 2016-11-03 |
BR112017023246B1 (pt) | 2021-09-08 |
TWI695070B (zh) | 2020-06-01 |
EP3288596B1 (de) | 2019-03-20 |
CA2983884A1 (en) | 2016-11-03 |
EP3088006A1 (de) | 2016-11-02 |
CN107624073A (zh) | 2018-01-23 |
SA517390240B1 (ar) | 2021-03-01 |
KR20170140219A (ko) | 2017-12-20 |
ZA201708043B (en) | 2020-01-29 |
JP2018517455A (ja) | 2018-07-05 |
RU2017141168A3 (tr) | 2019-11-14 |
US10434201B2 (en) | 2019-10-08 |
AR104440A1 (es) | 2017-07-19 |
BR112017023246A2 (pt) | 2020-05-19 |
AU2016254582A1 (en) | 2017-11-09 |
AU2016254582B2 (en) | 2020-01-30 |
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