AU2016254582B2 - Method for continuous virus inactivation in a microreactor - Google Patents

Method for continuous virus inactivation in a microreactor Download PDF

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Publication number
AU2016254582B2
AU2016254582B2 AU2016254582A AU2016254582A AU2016254582B2 AU 2016254582 B2 AU2016254582 B2 AU 2016254582B2 AU 2016254582 A AU2016254582 A AU 2016254582A AU 2016254582 A AU2016254582 A AU 2016254582A AU 2016254582 B2 AU2016254582 B2 AU 2016254582B2
Authority
AU
Australia
Prior art keywords
microreactor
virus inactivation
continuous virus
continuous
inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016254582A
Other versions
AU2016254582A1 (en
AU2016254582C1 (en
Inventor
Martin Lobedann
Peter Schwan
Andrea VESTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2016254582A1 publication Critical patent/AU2016254582A1/en
Application granted granted Critical
Publication of AU2016254582B2 publication Critical patent/AU2016254582B2/en
Publication of AU2016254582C1 publication Critical patent/AU2016254582C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0094—Gaseous substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AU2016254582A 2015-04-28 2016-04-25 Method for continuous virus inactivation in a microreactor Ceased AU2016254582C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15165505.7 2015-04-28
EP15165505.7A EP3088006A1 (en) 2015-04-28 2015-04-28 Method for continuous viral inactivation in a microreactor
PCT/EP2016/059169 WO2016173982A1 (en) 2015-04-28 2016-04-25 Method for continuous virus inactivation in a microreactor

Publications (3)

Publication Number Publication Date
AU2016254582A1 AU2016254582A1 (en) 2017-11-09
AU2016254582B2 true AU2016254582B2 (en) 2020-01-30
AU2016254582C1 AU2016254582C1 (en) 2020-04-30

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016254582A Ceased AU2016254582C1 (en) 2015-04-28 2016-04-25 Method for continuous virus inactivation in a microreactor

Country Status (21)

Country Link
US (1) US10434201B2 (en)
EP (2) EP3088006A1 (en)
JP (1) JP6851981B2 (en)
KR (1) KR20170140219A (en)
CN (1) CN107624073B (en)
AR (1) AR104440A1 (en)
AU (1) AU2016254582C1 (en)
BR (1) BR112017023246B1 (en)
CA (1) CA2983884A1 (en)
DK (1) DK3288596T3 (en)
ES (1) ES2720034T3 (en)
HK (1) HK1249867A1 (en)
IL (1) IL255137B (en)
MX (1) MX2017013893A (en)
RU (1) RU2719363C2 (en)
SA (1) SA517390240B1 (en)
SG (1) SG11201708749WA (en)
TR (1) TR201904906T4 (en)
TW (1) TWI695070B (en)
WO (1) WO2016173982A1 (en)
ZA (1) ZA201708043B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7117329B2 (en) * 2017-05-11 2022-08-12 イー・エム・デイー・ミリポア・コーポレイシヨン A mechanical method to maintain a narrow residence time distribution in continuous flow systems.
EP3621714A4 (en) * 2017-05-11 2021-01-20 EMD Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems
EP3651811A1 (en) 2017-07-10 2020-05-20 Baxalta Incorporated Method for incubating liquids and inactivating viruses
CN113015787A (en) * 2018-10-08 2021-06-22 勃林格殷格翰国际公司 Novel continuous flow reactor for low PH virus inactivation
DE102018009597A1 (en) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Device and method for multiple changes in the composition of a fluid
CN114247395B (en) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 Hollow fiber membrane type microchannel reactor and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103539A2 (en) * 2003-05-16 2004-12-02 Velocys Inc. Process for forming an emulsion using microchannel process technology
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
US20090269250A1 (en) * 2008-04-23 2009-10-29 Mfic Corporation Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017724A1 (en) * 1992-03-02 1993-09-16 Bioeng, Inc. Viral inactivation method
US6458335B1 (en) 1996-07-15 2002-10-01 Calcitech Ltd. Production of powders
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
DE10056096A1 (en) 2000-11-13 2002-06-13 Bayer Ag Device for irradiating liquids
DK1337280T3 (en) 2000-11-13 2013-12-02 Bayer Ip Gmbh METHOD OF INACTIVATING MICROORGANISMS IN A FLUID USING ULTRAVIOL RADIATION
DE10312765A1 (en) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Continuous method for sterilization and, if required, virus inactivation of fluid, in particular, aqueous reaction media involves combined heat treatment and ultraviolet irradiation of the reaction medium
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
US9566558B2 (en) * 2004-09-09 2017-02-14 Institut Curie Device for manipulation of packets in micro-containers, in particular in microchannels
CN1786018B (en) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 Separation and purification of high purity hemoglobin and virus inactivation technology
DE102006019242A1 (en) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Process analysis system with sterile sampling of mechanically sensitive material from a bioreactor
WO2009022381A1 (en) * 2007-08-10 2009-02-19 Photoscience Japan Corporation Short wavelength ultraviolet discharge lamp and ultraviolet irradiation treatment apparatus
AU2009307737B2 (en) * 2008-10-20 2015-07-23 Abbvie Inc. Viral inactivation during purification of antibodies
US8956566B2 (en) * 2012-03-12 2015-02-17 Pure Biosolutions, Llc System and method for virus inactivation
EP2918294A1 (en) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Device and method for continuous viral inactivation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103539A2 (en) * 2003-05-16 2004-12-02 Velocys Inc. Process for forming an emulsion using microchannel process technology
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology
US20090269250A1 (en) * 2008-04-23 2009-10-29 Mfic Corporation Apparatus and Methods For Nanoparticle Generation and Process Intensification of Transport and Reaction Systems

Also Published As

Publication number Publication date
HK1249867A1 (en) 2018-11-16
BR112017023246A2 (en) 2020-05-19
RU2017141168A3 (en) 2019-11-14
JP6851981B2 (en) 2021-03-31
BR112017023246B1 (en) 2021-09-08
US10434201B2 (en) 2019-10-08
SG11201708749WA (en) 2017-11-29
EP3288596A1 (en) 2018-03-07
IL255137A0 (en) 2017-12-31
JP2018517455A (en) 2018-07-05
CN107624073A (en) 2018-01-23
AU2016254582A1 (en) 2017-11-09
CN107624073B (en) 2020-05-22
ZA201708043B (en) 2020-01-29
SA517390240B1 (en) 2021-03-01
EP3088006A1 (en) 2016-11-02
IL255137B (en) 2020-10-29
TW201702377A (en) 2017-01-16
ES2720034T3 (en) 2019-07-17
WO2016173982A1 (en) 2016-11-03
KR20170140219A (en) 2017-12-20
RU2017141168A (en) 2019-05-28
AU2016254582C1 (en) 2020-04-30
TR201904906T4 (en) 2019-05-21
AR104440A1 (en) 2017-07-19
MX2017013893A (en) 2018-03-15
DK3288596T3 (en) 2019-05-06
TWI695070B (en) 2020-06-01
EP3288596B1 (en) 2019-03-20
RU2719363C2 (en) 2020-04-17
CA2983884A1 (en) 2016-11-03
US20190117803A1 (en) 2019-04-25

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DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 22 JAN 2020

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT FILED 22 JAN 2020

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired