BR112017023246B1 - Método para inativação contínua de vírus a partir de uma corrente de produto em um microrreator - Google Patents
Método para inativação contínua de vírus a partir de uma corrente de produto em um microrreator Download PDFInfo
- Publication number
- BR112017023246B1 BR112017023246B1 BR112017023246-4A BR112017023246A BR112017023246B1 BR 112017023246 B1 BR112017023246 B1 BR 112017023246B1 BR 112017023246 A BR112017023246 A BR 112017023246A BR 112017023246 B1 BR112017023246 B1 BR 112017023246B1
- Authority
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- Brazil
- Prior art keywords
- virus inactivation
- product
- product stream
- continuous
- inactivation
- Prior art date
Links
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Images
Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
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- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0094—Gaseous substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15165505.7A EP3088006A1 (de) | 2015-04-28 | 2015-04-28 | Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor |
| EP15165505.7 | 2015-04-28 | ||
| PCT/EP2016/059169 WO2016173982A1 (de) | 2015-04-28 | 2016-04-25 | Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017023246A2 BR112017023246A2 (pt) | 2020-05-19 |
| BR112017023246B1 true BR112017023246B1 (pt) | 2021-09-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017023246-4A BR112017023246B1 (pt) | 2015-04-28 | 2016-04-25 | Método para inativação contínua de vírus a partir de uma corrente de produto em um microrreator |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10434201B2 (enExample) |
| EP (2) | EP3088006A1 (enExample) |
| JP (1) | JP6851981B2 (enExample) |
| KR (1) | KR20170140219A (enExample) |
| CN (1) | CN107624073B (enExample) |
| AR (1) | AR104440A1 (enExample) |
| AU (1) | AU2016254582C1 (enExample) |
| BR (1) | BR112017023246B1 (enExample) |
| CA (1) | CA2983884A1 (enExample) |
| DK (1) | DK3288596T3 (enExample) |
| ES (1) | ES2720034T3 (enExample) |
| IL (1) | IL255137B (enExample) |
| MX (1) | MX380149B (enExample) |
| RU (1) | RU2719363C2 (enExample) |
| SA (1) | SA517390240B1 (enExample) |
| SG (1) | SG11201708749WA (enExample) |
| TR (1) | TR201904906T4 (enExample) |
| TW (1) | TWI695070B (enExample) |
| WO (1) | WO2016173982A1 (enExample) |
| ZA (1) | ZA201708043B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3621715A4 (en) * | 2017-05-11 | 2021-01-27 | EMD Millipore Corporation | MECHANICAL PROCEDURE FOR MAINTAINING TIGHT DISTRIBUTION OF DWELL TIME IN CONTINUOUS FLOW SYSTEMS |
| CA3062519A1 (en) * | 2017-05-11 | 2018-11-15 | Emd Millipore Corporation | Method of maintaining narrow residence time distributions in continuous flow systems using solid material packet interfaces |
| US20190022654A1 (en) | 2017-07-10 | 2019-01-24 | Baxalta Incorporated | Method for incubating liquids |
| US12435303B2 (en) | 2018-10-08 | 2025-10-07 | Boehringer Ingelheim International Gmbh | Continuous flow reactor for low pH viral inactivation |
| DE102018009597A1 (de) | 2018-12-07 | 2020-06-10 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids |
| CN114247395B (zh) * | 2020-09-23 | 2023-04-25 | 中国科学院大连化学物理研究所 | 一种中空纤维膜式微通道反应器及应用 |
| GB2631765A (en) | 2023-07-13 | 2025-01-15 | Univ Cranfield | Viral inactivation reactor and method |
| CN117298304B (zh) * | 2023-09-18 | 2025-08-22 | 浙江大学 | 一种组装式连续病毒灭活装置及其设计方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69329108T2 (de) * | 1992-03-02 | 2001-03-22 | Bioeng, Inc. | Verfahren zur inaktivierung von viren |
| DE69707288T2 (de) | 1996-07-15 | 2002-07-18 | Calcitech Ltd., Hamilton | Herstellung von pulvern |
| GB2359765B (en) * | 2000-03-02 | 2003-03-05 | Univ Newcastle | Capillary reactor distribution device and method |
| AU2002229545B2 (en) | 2000-11-13 | 2007-08-30 | Bayer Aktiengesellschaft | Method of inactivating microorganisms in a fluid using ultraviolet radiation |
| DE10056096A1 (de) | 2000-11-13 | 2002-06-13 | Bayer Ag | Vorrichtung zur Bestrahlung von Flüssigkeiten |
| DE10312765A1 (de) | 2003-03-21 | 2004-09-30 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung |
| US7485671B2 (en) * | 2003-05-16 | 2009-02-03 | Velocys, Inc. | Process for forming an emulsion using microchannel process technology |
| EP1633463B1 (en) * | 2003-05-16 | 2007-10-24 | Velocys Inc. | Process for forming an emulsion using microchannel process technology |
| US7993580B2 (en) * | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| JP5885901B2 (ja) * | 2004-09-09 | 2016-03-16 | アンスティテュート キュリー | マイクロチャネルまたは他のマイクロ容器中でパケットを操作するためのデバイス |
| US7622509B2 (en) * | 2004-10-01 | 2009-11-24 | Velocys, Inc. | Multiphase mixing process using microchannel process technology |
| CN1786018B (zh) * | 2005-12-12 | 2011-06-22 | 天津协和生物科技发展有限公司 | 高纯度血红蛋白的分离纯化与病毒灭活工艺 |
| DE102006019242A1 (de) | 2006-04-21 | 2007-10-25 | Bayer Technology Services Gmbh | Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor |
| WO2009022381A1 (ja) * | 2007-08-10 | 2009-02-19 | Photoscience Japan Corporation | 短波長紫外線放電灯及び紫外線照射処理装置 |
| US8187554B2 (en) * | 2008-04-23 | 2012-05-29 | Microfluidics International Corporation | Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems |
| NZ592097A (en) * | 2008-10-20 | 2013-01-25 | Abbott Lab | Viral inactivation during purification of il-12 and il-18 antibodies |
| US8956566B2 (en) * | 2012-03-12 | 2015-02-17 | Pure Biosolutions, Llc | System and method for virus inactivation |
| EP2918294A1 (de) * | 2014-03-11 | 2015-09-16 | Bayer Technology Services GmbH | Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung |
-
2015
- 2015-04-28 EP EP15165505.7A patent/EP3088006A1/de not_active Withdrawn
-
2016
- 2016-04-25 TR TR2019/04906T patent/TR201904906T4/tr unknown
- 2016-04-25 DK DK16718357.3T patent/DK3288596T3/da active
- 2016-04-25 JP JP2017556546A patent/JP6851981B2/ja not_active Expired - Fee Related
- 2016-04-25 RU RU2017141168A patent/RU2719363C2/ru active
- 2016-04-25 AU AU2016254582A patent/AU2016254582C1/en not_active Ceased
- 2016-04-25 WO PCT/EP2016/059169 patent/WO2016173982A1/de not_active Ceased
- 2016-04-25 MX MX2017013893A patent/MX380149B/es unknown
- 2016-04-25 US US15/569,635 patent/US10434201B2/en not_active Expired - Fee Related
- 2016-04-25 EP EP16718357.3A patent/EP3288596B1/de active Active
- 2016-04-25 CN CN201680024485.5A patent/CN107624073B/zh not_active Expired - Fee Related
- 2016-04-25 ES ES16718357T patent/ES2720034T3/es active Active
- 2016-04-25 CA CA2983884A patent/CA2983884A1/en not_active Abandoned
- 2016-04-25 SG SG11201708749WA patent/SG11201708749WA/en unknown
- 2016-04-25 BR BR112017023246-4A patent/BR112017023246B1/pt not_active IP Right Cessation
- 2016-04-25 KR KR1020177030712A patent/KR20170140219A/ko not_active Ceased
- 2016-04-26 TW TW105112897A patent/TWI695070B/zh not_active IP Right Cessation
- 2016-04-28 AR ARP160101209A patent/AR104440A1/es active IP Right Grant
-
2017
- 2017-10-19 IL IL255137A patent/IL255137B/en active IP Right Grant
- 2017-10-26 SA SA517390240A patent/SA517390240B1/ar unknown
- 2017-11-27 ZA ZA2017/08043A patent/ZA201708043B/en unknown
Also Published As
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| BR112017023246B1 (pt) | Método para inativação contínua de vírus a partir de uma corrente de produto em um microrreator | |
| CA2941901C (en) | Device and method for continuous virus inactivation | |
| CN106255542B (zh) | 用于从蛋白质溶液的连续缓冲或介质交换的超滤单元 | |
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| NZ723484B2 (en) | Device and method for continuous virus inactivation | |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
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