TWI695070B - 連續病毒去活性之方法 - Google Patents

連續病毒去活性之方法 Download PDF

Info

Publication number
TWI695070B
TWI695070B TW105112897A TW105112897A TWI695070B TW I695070 B TWI695070 B TW I695070B TW 105112897 A TW105112897 A TW 105112897A TW 105112897 A TW105112897 A TW 105112897A TW I695070 B TWI695070 B TW I695070B
Authority
TW
Taiwan
Prior art keywords
product stream
virus
deactivation
reactor
residence time
Prior art date
Application number
TW105112897A
Other languages
English (en)
Chinese (zh)
Other versions
TW201702377A (zh
Inventor
彼得 舒溫
安卓亞 維斯特
馬汀 羅柏丹恩
Original Assignee
德商拜耳廠股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 德商拜耳廠股份有限公司 filed Critical 德商拜耳廠股份有限公司
Publication of TW201702377A publication Critical patent/TW201702377A/zh
Application granted granted Critical
Publication of TWI695070B publication Critical patent/TWI695070B/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2103/05—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW105112897A 2015-04-28 2016-04-26 連續病毒去活性之方法 TWI695070B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15165505.7 2015-04-28
EP15165505.7A EP3088006A1 (de) 2015-04-28 2015-04-28 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor

Publications (2)

Publication Number Publication Date
TW201702377A TW201702377A (zh) 2017-01-16
TWI695070B true TWI695070B (zh) 2020-06-01

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105112897A TWI695070B (zh) 2015-04-28 2016-04-26 連續病毒去活性之方法

Country Status (20)

Country Link
US (1) US10434201B2 (enExample)
EP (2) EP3088006A1 (enExample)
JP (1) JP6851981B2 (enExample)
KR (1) KR20170140219A (enExample)
CN (1) CN107624073B (enExample)
AR (1) AR104440A1 (enExample)
AU (1) AU2016254582C1 (enExample)
BR (1) BR112017023246B1 (enExample)
CA (1) CA2983884A1 (enExample)
DK (1) DK3288596T3 (enExample)
ES (1) ES2720034T3 (enExample)
IL (1) IL255137B (enExample)
MX (1) MX380149B (enExample)
RU (1) RU2719363C2 (enExample)
SA (1) SA517390240B1 (enExample)
SG (1) SG11201708749WA (enExample)
TR (1) TR201904906T4 (enExample)
TW (1) TWI695070B (enExample)
WO (1) WO2016173982A1 (enExample)
ZA (1) ZA201708043B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110891665B (zh) * 2017-05-11 2022-01-14 Emd密理博公司 在连续流动体系中保持窄停留时间分布的机械方法
EP3621714A4 (en) * 2017-05-11 2021-01-20 EMD Millipore Corporation METHOD OF MAINTAINING NARROW RESIDENTIAL TIME DISTRIBUTIONS IN CONTINUOUS FLOW SYSTEMS
CN111050809B (zh) 2017-07-10 2021-12-24 武田药品工业株式会社 孵育液体和灭活病毒的方法
AU2019357965A1 (en) * 2018-10-08 2021-04-29 Boehringer Ingelheim International Gmbh A novel continuous flow reactor for low pH viral inactivation
DE102018009597A1 (de) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
CN114247395B (zh) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 一种中空纤维膜式微通道反应器及应用
GB2631765A (en) 2023-07-13 2025-01-15 Univ Cranfield Viral inactivation reactor and method
CN117298304B (zh) * 2023-09-18 2025-08-22 浙江大学 一种组装式连续病毒灭活装置及其设计方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017724A1 (en) * 1992-03-02 1993-09-16 Bioeng, Inc. Viral inactivation method
WO1998002237A1 (en) 1996-07-15 1998-01-22 Kemgas Limited Production of powders
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
AU2954502A (en) 2000-11-13 2002-05-21 Bayer Ag Method of inactivating microorganisms in a fluid using ultraviolet radiation
DE10056096A1 (de) 2000-11-13 2002-06-13 Bayer Ag Vorrichtung zur Bestrahlung von Flüssigkeiten
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
ATE376451T1 (de) * 2003-05-16 2007-11-15 Velocys Inc Verfahren zur erzeugung einer emulsion durch verwendung einer mikrokanalverfahrentechnologie
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
EP1802395B1 (en) * 2004-09-09 2020-01-22 Institut Curie Microfluidic device using a collinear electric field
CN1786018B (zh) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
CN101772821A (zh) * 2007-08-10 2010-07-07 株式会社日本光电科技 短波长紫外线放电灯和紫外线照射处理装置
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
NZ592097A (en) * 2008-10-20 2013-01-25 Abbott Lab Viral inactivation during purification of il-12 and il-18 antibodies
US8956566B2 (en) * 2012-03-12 2015-02-17 Pure Biosolutions, Llc System and method for virus inactivation
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006039568A1 (en) * 2004-10-01 2006-04-13 Velocys Inc. Multiphase mixing process using microchannel process technology

Also Published As

Publication number Publication date
WO2016173982A1 (de) 2016-11-03
ES2720034T3 (es) 2019-07-17
TR201904906T4 (tr) 2019-05-21
EP3288596A1 (de) 2018-03-07
EP3088006A1 (de) 2016-11-02
CA2983884A1 (en) 2016-11-03
CN107624073A (zh) 2018-01-23
BR112017023246A2 (pt) 2020-05-19
SG11201708749WA (en) 2017-11-29
IL255137A0 (en) 2017-12-31
KR20170140219A (ko) 2017-12-20
AU2016254582C1 (en) 2020-04-30
EP3288596B1 (de) 2019-03-20
AR104440A1 (es) 2017-07-19
IL255137B (en) 2020-10-29
RU2719363C2 (ru) 2020-04-17
ZA201708043B (en) 2020-01-29
US10434201B2 (en) 2019-10-08
JP2018517455A (ja) 2018-07-05
HK1249867A1 (zh) 2018-11-16
DK3288596T3 (da) 2019-05-06
TW201702377A (zh) 2017-01-16
AU2016254582A1 (en) 2017-11-09
MX2017013893A (es) 2018-03-15
RU2017141168A (ru) 2019-05-28
BR112017023246B1 (pt) 2021-09-08
JP6851981B2 (ja) 2021-03-31
RU2017141168A3 (enExample) 2019-11-14
US20190117803A1 (en) 2019-04-25
MX380149B (es) 2025-03-12
CN107624073B (zh) 2020-05-22
AU2016254582B2 (en) 2020-01-30
SA517390240B1 (ar) 2021-03-01

Similar Documents

Publication Publication Date Title
TWI695070B (zh) 連續病毒去活性之方法
CA2941901C (en) Device and method for continuous virus inactivation
TWI698529B (zh) 連續流動系統中保持窄滯留時間分布的方法
AU2018340247B2 (en) Unit operation and use thereof
TWI686471B (zh) 流體通道及連續流動系統中保持窄滯留時間分布的機械方法
HK1249867B (zh) 用於在微反应器中连续病毒灭活的方法
NZ723484B2 (en) Device and method for continuous virus inactivation
HK1226973B (zh) 用於连续病毒灭活的装置和方法
HK1226973A1 (zh) 用於连续病毒灭活的装置和方法

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees