CN107532050B - 用于透皮给药的压敏粘合剂 - Google Patents

用于透皮给药的压敏粘合剂 Download PDF

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Publication number
CN107532050B
CN107532050B CN201680019164.6A CN201680019164A CN107532050B CN 107532050 B CN107532050 B CN 107532050B CN 201680019164 A CN201680019164 A CN 201680019164A CN 107532050 B CN107532050 B CN 107532050B
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China
Prior art keywords
skin
monomer
psa
tris
monomethacrylate
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English (en)
Chinese (zh)
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CN107532050A (zh
Inventor
J.张
J.廖
P.刘
S.丁
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Noven Pharmaceuticals Inc
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Noven Pharmaceuticals Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04Homopolymers or copolymers of esters
    • C09J133/06Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04Homopolymers or copolymers of esters
    • C09J133/14Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09JADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/24Homopolymers or copolymers of amides or imides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Adhesive Tapes (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Laminated Bodies (AREA)
CN201680019164.6A 2015-02-06 2016-02-05 用于透皮给药的压敏粘合剂 Active CN107532050B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112982P 2015-02-06 2015-02-06
US62/112982 2015-02-06
PCT/US2016/016696 WO2016127020A1 (en) 2015-02-06 2016-02-05 Pressure-sensitive adhesives for transdermal drug delivery

Publications (2)

Publication Number Publication Date
CN107532050A CN107532050A (zh) 2018-01-02
CN107532050B true CN107532050B (zh) 2021-03-02

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CN201680019164.6A Active CN107532050B (zh) 2015-02-06 2016-02-05 用于透皮给药的压敏粘合剂

Country Status (13)

Country Link
US (1) US10406115B2 (https=)
EP (1) EP3253840B1 (https=)
JP (2) JP6807848B2 (https=)
KR (1) KR102565565B1 (https=)
CN (1) CN107532050B (https=)
AU (1) AU2016215180B2 (https=)
CA (1) CA2975452C (https=)
ES (1) ES2748352T3 (https=)
HK (1) HK1248265B (https=)
MX (1) MX371044B (https=)
PH (1) PH12017501371B1 (https=)
TW (1) TWI689321B (https=)
WO (1) WO2016127020A1 (https=)

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AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
EP3253840B1 (en) 2015-02-06 2019-07-31 Noven Pharmaceuticals, INC. Pressure-sensitive adhesives for transdermal drug delivery
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
EP3506889A1 (en) * 2016-08-03 2019-07-10 Noven Pharmaceuticals, INC. Pressure-sensitive adhesives for transdermal drug delivery
CA3049529A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
JP2019183078A (ja) * 2018-04-17 2019-10-24 日立化成株式会社 粘着剤
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems
US12397141B2 (en) 2018-11-16 2025-08-26 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
CN114207073B (zh) * 2019-07-30 2023-12-05 日东电工株式会社 粘合剂组合物、粘合剂层及粘合片
JP7802011B2 (ja) * 2020-05-04 2026-01-19 ビーブイダブリュ インベスト エージー 膨潤を介して対象表面に接着する接着装置
CA3203042A1 (en) 2021-01-07 2022-07-14 Deboprosad MONDAL Amphetamine carbamate compounds and methods
TW202241397A (zh) 2021-01-07 2022-11-01 美商諾芬藥品公司 含低量胺基甲酸鹽之經皮安非他命組合物
CN116139287A (zh) * 2023-02-23 2023-05-23 杭州创剂医药科技有限公司 含羟苯基聚丙烯酸酯的压敏胶基质及其制备方法
US12514756B1 (en) 2024-10-08 2026-01-06 Covidien Lp Dermal patch and systems, kits, and methods associated therewith

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CN101291962A (zh) * 2005-09-23 2008-10-22 国家淀粉及化学投资控股公司 丙烯酸类聚合物基粘合剂
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Publication number Publication date
KR102565565B1 (ko) 2023-08-09
HK1248265B (en) 2020-04-03
WO2016127020A1 (en) 2016-08-11
CA2975452A1 (en) 2016-08-11
EP3253840A1 (en) 2017-12-13
JP2018510926A (ja) 2018-04-19
CN107532050A (zh) 2018-01-02
TWI689321B (zh) 2020-04-01
PH12017501371B1 (en) 2022-10-26
US10406115B2 (en) 2019-09-10
US20160228383A1 (en) 2016-08-11
CA2975452C (en) 2024-03-12
AU2016215180B2 (en) 2020-01-02
AU2016215180A1 (en) 2017-08-17
JP2021073324A (ja) 2021-05-13
MX371044B (es) 2020-01-13
PH12017501371A1 (en) 2017-12-18
ES2748352T3 (es) 2020-03-16
JP6807848B2 (ja) 2021-01-06
MX2017010000A (es) 2018-02-19
KR20170113636A (ko) 2017-10-12
EP3253840B1 (en) 2019-07-31
TW201634064A (zh) 2016-10-01

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