CN107531745A - 一种新的18α‑甘草次酸衍生物及其医药用途 - Google Patents

一种新的18α‑甘草次酸衍生物及其医药用途 Download PDF

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Publication number
CN107531745A
CN107531745A CN201680028986.0A CN201680028986A CN107531745A CN 107531745 A CN107531745 A CN 107531745A CN 201680028986 A CN201680028986 A CN 201680028986A CN 107531745 A CN107531745 A CN 107531745A
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enoxolone
values
choline salt
ray powder
crystal form
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CN107531745B (zh
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张喜全
张爱明
徐宏江
董平
周浩
田心
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)

Abstract

本发明涉及一种新的18α‑甘草次酸衍生物及其医药用途。该化合物对11β‑羟基类固醇脱氢酶抑制弱，能够有效改善甘草次酸类药物的肾上腺皮质激素样类不良反应，降低水钠潴留风险。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201680028986.0A 2015-05-19 2016-05-19 一种新的18α-甘草次酸衍生物及其医药用途 Active CN107531745B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510258072 2015-05-19
CN2015102580720 2015-05-19
PCT/CN2016/082646 WO2016184400A1 (zh) 2015-05-19 2016-05-19 一种新的18α-甘草次酸衍生物及其医药用途

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CN107531745A true CN107531745A (zh) 2018-01-02
CN107531745B CN107531745B (zh) 2019-11-29

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CN (1) CN107531745B (zh)
WO (1) WO2016184400A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111018938A (zh) * 2019-12-10 2020-04-17 中国人民解放军第二军医大学 一种五环三萜类甘草次酸衍生物及制备方法与应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106565817A (zh) * 2016-11-09 2017-04-19 深圳市新阳唯康科技有限公司 一种无定型甘草次酸及其制备方法
CN106632575A (zh) * 2016-12-20 2017-05-10 深圳市新阳唯康科技有限公司 一种甘草次酸新晶型及其制备方法
CN108276468B (zh) * 2018-03-13 2019-12-31 中国农业科学院兰州畜牧与兽药研究所 一种甘草次酸酯及其制备方法和在制备抗病毒药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB870651A (en) * 1959-03-11 1961-06-14 Biorex Laboratories Ltd Glycyrrhetinic acid derivatives
JPH0782155A (ja) * 1993-09-10 1995-03-28 Minofuaagen Seiyaku Honpo:Goushi グリチルリチン酸直腸製剤
CN1563073A (zh) * 2004-04-06 2005-01-12 南开大学 甘草次酸的制备方法
CN1762967A (zh) * 2004-09-17 2006-04-26 山东绿叶制药有限公司 甘草次酸衍生物、制备方法及其用途
JP2009062322A (ja) * 2007-09-06 2009-03-26 Minofuaagen Seiyaku:Kk 肝実質細胞再生促進剤
CN101486751A (zh) * 2009-03-05 2009-07-22 杭州市中医院 18α-甘草次酸邻酞酸盐及其制备方法和应用
CN101775059A (zh) * 2010-02-04 2010-07-14 中国药科大学 新的甘草次酸衍生物、其制备方法及其医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104250278A (zh) * 2013-06-28 2014-12-31 江苏天晟药业有限公司 一种18α-甘草酸次酸的制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB870651A (en) * 1959-03-11 1961-06-14 Biorex Laboratories Ltd Glycyrrhetinic acid derivatives
JPH0782155A (ja) * 1993-09-10 1995-03-28 Minofuaagen Seiyaku Honpo:Goushi グリチルリチン酸直腸製剤
CN1563073A (zh) * 2004-04-06 2005-01-12 南开大学 甘草次酸的制备方法
CN1762967A (zh) * 2004-09-17 2006-04-26 山东绿叶制药有限公司 甘草次酸衍生物、制备方法及其用途
JP2009062322A (ja) * 2007-09-06 2009-03-26 Minofuaagen Seiyaku:Kk 肝実質細胞再生促進剤
CN101486751A (zh) * 2009-03-05 2009-07-22 杭州市中医院 18α-甘草次酸邻酞酸盐及其制备方法和应用
CN101775059A (zh) * 2010-02-04 2010-07-14 中国药科大学 新的甘草次酸衍生物、其制备方法及其医药用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111018938A (zh) * 2019-12-10 2020-04-17 中国人民解放军第二军医大学 一种五环三萜类甘草次酸衍生物及制备方法与应用
CN111018938B (zh) * 2019-12-10 2021-05-25 中国人民解放军第二军医大学 一种五环三萜类甘草次酸衍生物及制备方法与应用

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CN107531745B (zh) 2019-11-29

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