CN1072932C - 用四氢苯并[cd]吲哚－6－甲酰胺类化合物预防呕吐和治疗性机能障碍的方法 - Google Patents

用四氢苯并[cd]吲哚－6－甲酰胺类化合物预防呕吐和治疗性机能障碍的方法 Download PDF

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Publication number
CN1072932C
CN1072932C CN94106467A CN94106467A CN1072932C CN 1072932 C CN1072932 C CN 1072932C CN 94106467 A CN94106467 A CN 94106467A CN 94106467 A CN94106467 A CN 94106467A CN 1072932 C CN1072932 C CN 1072932C
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CN
China
Prior art keywords
indole
tetrahydrobenzo
carboxamide
sexual dysfunction
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94106467A
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English (en)
Chinese (zh)
Other versions
CN1100634A (zh
Inventor
M·M·福尔曼
J·D·李安达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1100634A publication Critical patent/CN1100634A/zh
Application granted granted Critical
Publication of CN1072932C publication Critical patent/CN1072932C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN94106467A 1993-06-10 1994-06-09 用四氢苯并[cd]吲哚－6－甲酰胺类化合物预防呕吐和治疗性机能障碍的方法 Expired - Fee Related CN1072932C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7519893A 1993-06-10 1993-06-10
US075198 1993-06-10
US075,198 1993-06-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB00132828XA Division CN1170536C (zh) 1993-06-10 2000-10-31 四氢苯并[cd]吲哚-6-甲酰胺类化合物在制备用于预防呕吐的药物中的用途

Publications (2)

Publication Number Publication Date
CN1100634A CN1100634A (zh) 1995-03-29
CN1072932C true CN1072932C (zh) 2001-10-17

Family

ID=22124191

Family Applications (2)

Application Number Title Priority Date Filing Date
CN94106467A Expired - Fee Related CN1072932C (zh) 1993-06-10 1994-06-09 用四氢苯并[cd]吲哚－6－甲酰胺类化合物预防呕吐和治疗性机能障碍的方法
CNB00132828XA Expired - Fee Related CN1170536C (zh) 1993-06-10 2000-10-31 四氢苯并[cd]吲哚-6-甲酰胺类化合物在制备用于预防呕吐的药物中的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB00132828XA Expired - Fee Related CN1170536C (zh) 1993-06-10 2000-10-31 四氢苯并[cd]吲哚-6-甲酰胺类化合物在制备用于预防呕吐的药物中的用途

Country Status (17)

Country Link
US (1) US5703112A (enExample)
EP (2) EP1166783A3 (enExample)
JP (1) JPH0748254A (enExample)
KR (2) KR100367792B1 (enExample)
CN (2) CN1072932C (enExample)
AU (1) AU677317B2 (enExample)
CA (1) CA2125088A1 (enExample)
CZ (2) CZ285762B6 (enExample)
HK (1) HK1043322B (enExample)
HU (1) HUT71464A (enExample)
IL (1) IL109872A (enExample)
NO (4) NO321500B1 (enExample)
NZ (2) NZ260667A (enExample)
RU (1) RU2154476C2 (enExample)
TW (1) TW258660B (enExample)
UA (2) UA29415C2 (enExample)
ZA (1) ZA943862B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173167A4 (en) 1999-04-30 2004-07-14 Lilly Icos Llc TREATMENT OF FEMALE SEXUAL STIMULATION DISORDERS
RU2154490C1 (ru) * 1999-07-15 2000-08-20 Кибрик Николай Давидович Способ лечения сексуальных расстройств диэнцефального генеза у мужчин
GB0106446D0 (en) * 2001-03-15 2001-05-02 Vernalis Res Ltd Chemical compounds
RU2200556C1 (ru) * 2001-12-05 2003-03-20 Северцев Владимир Алексеевич Лекарственная форма налтрексона
KR101335941B1 (ko) 2005-06-08 2013-12-04 에스케이바이오팜 주식회사 수면-각성 장애의 치료
JP5298334B2 (ja) * 2005-06-22 2013-09-25 エスケー ホルディングス カンパニー リミテッド 性機能障害を治療する方法
MX2012000034A (es) 2009-06-22 2012-02-21 Sk Biopharmaceuticals Co Ltd Metodos para el tratamiento o la prevencion de la fatiga.
EP2496228B1 (en) 2009-11-06 2014-01-15 SK Biopharmaceuticals Co., Ltd. Methods for treating attention-deficit/hyperactivity disorder
AU2010316172B2 (en) 2009-11-06 2015-11-12 Sk Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
RU2019114940A (ru) 2013-03-13 2019-06-28 ЭРИЭЛ БАЙОФАРМА, ЭлЭлСи Лечение катаплексии
US9226910B2 (en) 2013-07-18 2016-01-05 Jazz Pharmaceuticals International Iii Limited Treatment for obesity
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
BR112019025286A2 (pt) 2017-06-02 2020-06-23 Jazz Pharmaceuticals Ireland Limited Métodos e composições para tratamento de sonolência excessiva
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285278A2 (en) * 1987-03-12 1988-10-05 Eli Lilly And Company The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4521421A (en) * 1983-09-26 1985-06-04 Eli Lilly And Company Treatment of sexual dysfunction
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
US4943428A (en) * 1987-07-10 1990-07-24 Wright State University Stimulation of serotonin-1A receptors in mammals to alleviate motion sickness and emesis induced by chemical agents
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
AU648032B2 (en) * 1989-07-13 1994-04-14 Pharmacia & Upjohn Company (1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
EP0594593A1 (en) * 1990-03-15 1994-05-04 PHARMACIA & UPJOHN COMPANY Therapeutically useful heterocyclic indole compounds
US5258379A (en) * 1990-05-04 1993-11-02 Eli Lilly And Company Method of inhibiting gastric acid secretion with n-arylpiperazines
US5096908A (en) * 1990-05-04 1992-03-17 Eli Lilly And Company Method of inhibiting gastric acid secretion
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285278A2 (en) * 1987-03-12 1988-10-05 Eli Lilly And Company The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety

Also Published As

Publication number Publication date
CZ285829B6 (cs) 1999-11-17
NZ260667A (en) 1997-05-26
CN1100634A (zh) 1995-03-29
NO993461D0 (no) 1999-07-14
KR950000146A (ko) 1995-01-03
IL109872A0 (en) 1994-10-07
NO991551D0 (no) 1999-03-30
CA2125088A1 (en) 1994-12-11
EP1166783A2 (en) 2002-01-02
US5703112A (en) 1997-12-30
KR100367792B1 (ko) 2003-02-19
AU677317B2 (en) 1997-04-17
RU94020717A (ru) 1996-08-27
EP0633023A2 (en) 1995-01-11
UA29415C2 (uk) 2000-11-15
NO20015806L (no) 1994-12-12
KR100367791B1 (ko) 2003-02-14
AU6460794A (en) 1994-12-15
CN1170536C (zh) 2004-10-13
JPH0748254A (ja) 1995-02-21
NO321500B1 (no) 2006-05-15
HK1043322A1 (en) 2002-09-13
NO942143D0 (no) 1994-06-09
CZ285762B6 (cs) 1999-11-17
ZA943862B (en) 1995-12-04
EP1166783A3 (en) 2002-01-09
NO991551L (no) 1994-12-12
EP0633023A3 (en) 1995-03-29
CZ135494A3 (en) 1994-12-15
NO993461L (no) 1994-12-12
NZ314570A (en) 2000-11-24
HUT71464A (en) 1995-11-28
NO20015806D0 (no) 2001-11-28
TW258660B (enExample) 1995-10-01
HU9401730D0 (en) 1994-09-28
NO308693B1 (no) 2000-10-16
NO942143L (no) 1994-12-12
CN1342457A (zh) 2002-04-03
HK1043322B (zh) 2005-06-03
RU2154476C2 (ru) 2000-08-20
IL109872A (en) 2000-12-06
UA37311C2 (uk) 2001-05-15

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C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee