CN107266467A - 用作ampk的活化剂的噻吩并吡啶酮衍生物 - Google Patents
用作ampk的活化剂的噻吩并吡啶酮衍生物 Download PDFInfo
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- CN107266467A CN107266467A CN201710493350.XA CN201710493350A CN107266467A CN 107266467 A CN107266467 A CN 107266467A CN 201710493350 A CN201710493350 A CN 201710493350A CN 107266467 A CN107266467 A CN 107266467A
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- pyridine
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- thienos
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- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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- 239000002994 raw material Substances 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
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- 239000005060 rubber Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- RCOSUMRTSQULBK-UHFFFAOYSA-N sodium;propan-1-olate Chemical compound [Na+].CCC[O-] RCOSUMRTSQULBK-UHFFFAOYSA-N 0.000 description 1
- PANBYUAFMMOFOV-UHFFFAOYSA-N sodium;sulfuric acid Chemical compound [Na].OS(O)(=O)=O PANBYUAFMMOFOV-UHFFFAOYSA-N 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
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- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- NBRKLOOSMBRFMH-UHFFFAOYSA-N tert-butyl chloride Chemical compound CC(C)(C)Cl NBRKLOOSMBRFMH-UHFFFAOYSA-N 0.000 description 1
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- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 108091006108 transcriptional coactivators Proteins 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WQSWVILYSJZJQS-UHFFFAOYSA-K trisodium;2-chloro-3-(1-oxido-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenylthieno[2,3-b]pyridine-4,6-diolate Chemical compound [Na+].[Na+].[Na+].[O-]C1=NC=2SC(Cl)=C(C=3C(=C4CCCCC4=CC=3)[O-])C=2C([O-])=C1C1=CC=CC=C1 WQSWVILYSJZJQS-UHFFFAOYSA-K 0.000 description 1
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- 208000019553 vascular disease Diseases 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305775.4 | 2012-06-29 | ||
| EP12305775.4A EP2679591A1 (en) | 2012-06-29 | 2012-06-29 | Thienopyridone derivatives useful as activators of AMPK |
| CN201380034638.0A CN104395319B (zh) | 2012-06-29 | 2013-06-28 | 用作ampk的活化剂的噻吩并吡啶酮衍生物 |
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| CN201380034638.0A Division CN104395319B (zh) | 2012-06-29 | 2013-06-28 | 用作ampk的活化剂的噻吩并吡啶酮衍生物 |
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| CN107266467A true CN107266467A (zh) | 2017-10-20 |
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| CN201710493350.XA Pending CN107266467A (zh) | 2012-06-29 | 2013-06-28 | 用作ampk的活化剂的噻吩并吡啶酮衍生物 |
| CN201380034638.0A Active CN104395319B (zh) | 2012-06-29 | 2013-06-28 | 用作ampk的活化剂的噻吩并吡啶酮衍生物 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201380034638.0A Active CN104395319B (zh) | 2012-06-29 | 2013-06-28 | 用作ampk的活化剂的噻吩并吡啶酮衍生物 |
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| EP (2) | EP2679591A1 (https=) |
| JP (1) | JP5972460B2 (https=) |
| KR (1) | KR101704448B1 (https=) |
| CN (2) | CN107266467A (https=) |
| AU (1) | AU2013283239B2 (https=) |
| BR (1) | BR112014032526B1 (https=) |
| CA (1) | CA2876789C (https=) |
| CY (1) | CY1118213T1 (https=) |
| DK (1) | DK2867240T3 (https=) |
| EA (1) | EA026300B1 (https=) |
| ES (1) | ES2603737T3 (https=) |
| HR (1) | HRP20161482T1 (https=) |
| HU (1) | HUE030946T2 (https=) |
| IL (1) | IL236221A (https=) |
| IN (1) | IN2014MN02661A (https=) |
| LT (1) | LT2867240T (https=) |
| ME (1) | ME02537B (https=) |
| MX (1) | MX359221B (https=) |
| PL (1) | PL2867240T3 (https=) |
| PT (1) | PT2867240T (https=) |
| RS (1) | RS55308B1 (https=) |
| SI (1) | SI2867240T1 (https=) |
| SM (1) | SMT201600418B (https=) |
| WO (1) | WO2014001554A1 (https=) |
| ZA (1) | ZA201500593B (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108516972A (zh) * | 2018-05-30 | 2018-09-11 | 王丽萍 | 一种goat抑制剂及其在肥胖和糖尿病中的应用 |
| CN114727979A (zh) * | 2019-11-27 | 2022-07-08 | 雀巢产品有限公司 | 二苯并吡喃ampk活化剂化合物、组合物、方法及其用途 |
| CN115335048A (zh) * | 2020-03-26 | 2022-11-11 | 博希尔公司 | 噻吩并吡啶酮衍生物在治疗肾上腺脑白质营养不良或肾上腺脊髓神经病中的用途 |
| CN115361949A (zh) * | 2020-04-02 | 2022-11-18 | 博希尔公司 | 噻吩并吡啶酮衍生物在治疗常染色体显性多囊肾病adpkd中的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105078992B (zh) * | 2014-05-23 | 2017-11-21 | 资元堂生物科技股份有限公司 | 异喹啉生物碱衍生物用于制备促进ampk活性的药物的用途 |
| CN104892569A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途 |
| CN105037321A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途 |
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| CN104945369A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104945370A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
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| CN104910129A (zh) * | 2015-06-23 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环和卤代苯结构的黄原酸酯类化合物、其制备方法及用途 |
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| CN115335048A (zh) * | 2020-03-26 | 2022-11-11 | 博希尔公司 | 噻吩并吡啶酮衍生物在治疗肾上腺脑白质营养不良或肾上腺脊髓神经病中的用途 |
| CN115335048B (zh) * | 2020-03-26 | 2025-04-04 | 博希尔公司 | 噻吩并吡啶酮衍生物在治疗肾上腺脑白质营养不良或肾上腺脊髓神经病中的用途 |
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