SMT201600418B - Derivati di tienopiridone come attivatori della ampk - Google Patents
Derivati di tienopiridone come attivatori della ampkInfo
- Publication number
- SMT201600418B SMT201600418B SM201600418T SM201600418T SMT201600418B SM T201600418 B SMT201600418 B SM T201600418B SM 201600418 T SM201600418 T SM 201600418T SM 201600418 T SM201600418 T SM 201600418T SM T201600418 B SMT201600418 B SM T201600418B
- Authority
- SM
- San Marino
- Prior art keywords
- thenopyridone
- derivatives
- ampk activators
- ampk
- activators
- Prior art date
Links
- 102100036009 5'-AMP-activated protein kinase catalytic subunit alpha-2 Human genes 0.000 title 1
- 101000783681 Homo sapiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305775.4A EP2679591A1 (en) | 2012-06-29 | 2012-06-29 | Thienopyridone derivatives useful as activators of AMPK |
| PCT/EP2013/063741 WO2014001554A1 (en) | 2012-06-29 | 2013-06-28 | Thienopyridone derivatives useful as activators of ampk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600418B true SMT201600418B (it) | 2017-01-10 |
Family
ID=48703549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600418T SMT201600418B (it) | 2012-06-29 | 2016-11-17 | Derivati di tienopiridone come attivatori della ampk |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9284329B2 (it) |
| EP (2) | EP2679591A1 (it) |
| JP (1) | JP5972460B2 (it) |
| KR (1) | KR101704448B1 (it) |
| CN (2) | CN107266467A (it) |
| AU (1) | AU2013283239B2 (it) |
| BR (1) | BR112014032526B1 (it) |
| CA (1) | CA2876789C (it) |
| CY (1) | CY1118213T1 (it) |
| DK (1) | DK2867240T3 (it) |
| EA (1) | EA026300B1 (it) |
| ES (1) | ES2603737T3 (it) |
| HR (1) | HRP20161482T1 (it) |
| HU (1) | HUE030946T2 (it) |
| IL (1) | IL236221A (it) |
| IN (1) | IN2014MN02661A (it) |
| LT (1) | LT2867240T (it) |
| ME (1) | ME02537B (it) |
| MX (1) | MX359221B (it) |
| PL (1) | PL2867240T3 (it) |
| PT (1) | PT2867240T (it) |
| RS (1) | RS55308B1 (it) |
| SI (1) | SI2867240T1 (it) |
| SM (1) | SMT201600418B (it) |
| WO (1) | WO2014001554A1 (it) |
| ZA (1) | ZA201500593B (it) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078992B (zh) * | 2014-05-23 | 2017-11-21 | 资元堂生物科技股份有限公司 | 异喹啉生物碱衍生物用于制备促进ampk活性的药物的用途 |
| CN104910129A (zh) * | 2015-06-23 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环和卤代苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104945370A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN104910130A (zh) * | 2015-06-23 | 2015-09-16 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和氨基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104945369A (zh) * | 2015-06-23 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104892569A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途 |
| CN105037321A (zh) * | 2015-06-23 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途 |
| CN104892568A (zh) * | 2015-06-23 | 2015-09-09 | 佛山市赛维斯医药科技有限公司 | 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途 |
| CN104945371A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN105001181A (zh) * | 2015-06-24 | 2015-10-28 | 佛山市赛维斯医药科技有限公司 | 一类双酰基苄胺类的ampk激活剂、其制备方法及用途 |
| CN104926756A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途 |
| CN104926757A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途 |
| CN104926755A (zh) * | 2015-06-24 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途 |
| CN105037296A (zh) * | 2015-06-24 | 2015-11-11 | 佛山市赛维斯医药科技有限公司 | 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途 |
| CN104945372A (zh) * | 2015-06-24 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途 |
| CN105541715B (zh) * | 2016-02-02 | 2019-04-09 | 浙江工业大学 | 多取代吡啶-1(2h)-酮衍生物及其合成方法与应用 |
| KR101925020B1 (ko) | 2017-04-21 | 2018-12-04 | 연세대학교 산학협력단 | Mkrn1의 발현 또는 활성 억제제를 유효성분으로 함유하는, 대사성 질환의 예방 및 치료용 약학적 조성물 |
| WO2019154956A1 (en) * | 2018-02-08 | 2019-08-15 | Enyo Pharma | Non-fused thiophene derivatives and their uses |
| CN108516972A (zh) * | 2018-05-30 | 2018-09-11 | 王丽萍 | 一种goat抑制剂及其在肥胖和糖尿病中的应用 |
| ES2970120T3 (es) * | 2018-11-16 | 2024-05-27 | Poxel | Sal de potasio monohidratada de un derivado de tienopiridona y su proceso de preparación |
| WO2020215034A1 (en) * | 2019-04-19 | 2020-10-22 | The Regents Of The University Of California | An ampk/caspase-6 axis controls liver damage in nonalcoholic steatohepatitis |
| WO2021037702A1 (en) | 2019-08-28 | 2021-03-04 | Poxel | Pharmaceutical combination of a specific thienopyridone derivative with an fxr agonist for the treatment of liver diseases |
| EP4065104A1 (en) * | 2019-11-27 | 2022-10-05 | Société des Produits Nestlé S.A. | Dibenzopyran ampk activator compounds, compositions, methods and uses thereof |
| WO2021191435A1 (en) * | 2020-03-26 | 2021-09-30 | Poxel | Use of a thienopyridone derivative in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy |
| WO2021198284A1 (en) | 2020-03-30 | 2021-10-07 | Poxel | Use of a thienopyridone derivative in the treatment of cardiovascular diseases |
| WO2021198099A1 (en) | 2020-03-30 | 2021-10-07 | Poxel | Use of a thienopyridone derivative in the treatment of diabetic nephropathy |
| US12310949B2 (en) | 2020-04-02 | 2025-05-27 | Poxel | Use of a thienopyridone derivative in the treatment of autosomal dominant polycystic kidney disease (ADPKD) |
| WO2021204755A1 (en) | 2020-04-06 | 2021-10-14 | Poxel | Pharmaceutical combination for the treatment of liver diseases |
| WO2021204751A1 (en) | 2020-04-06 | 2021-10-14 | Poxel | Pharmaceutical combination for the treatment of liver diseases |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| EP4221700A1 (en) | 2020-09-30 | 2023-08-09 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
| US7119205B2 (en) | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| EP1754483A1 (en) * | 2005-08-18 | 2007-02-21 | Merck Sante | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them |
| MX2010011047A (es) * | 2008-04-11 | 2010-10-26 | Merck Patent Gmbh | Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk). |
| MY160357A (en) | 2008-05-05 | 2017-02-28 | Merck Patent Gmbh | Thienopyridone derivatives as amp-activated protein kinase (ampk) activators |
-
2012
- 2012-06-29 EP EP12305775.4A patent/EP2679591A1/en not_active Ceased
-
2013
- 2013-06-28 EA EA201500064A patent/EA026300B1/ru not_active IP Right Cessation
- 2013-06-28 LT LTEP13732533.8T patent/LT2867240T/lt unknown
- 2013-06-28 BR BR112014032526-0A patent/BR112014032526B1/pt active IP Right Grant
- 2013-06-28 DK DK13732533.8T patent/DK2867240T3/en active
- 2013-06-28 SI SI201330379A patent/SI2867240T1/sl unknown
- 2013-06-28 WO PCT/EP2013/063741 patent/WO2014001554A1/en not_active Ceased
- 2013-06-28 CA CA2876789A patent/CA2876789C/en active Active
- 2013-06-28 AU AU2013283239A patent/AU2013283239B2/en active Active
- 2013-06-28 MX MX2014016107A patent/MX359221B/es active IP Right Grant
- 2013-06-28 HU HUE13732533A patent/HUE030946T2/en unknown
- 2013-06-28 HR HRP20161482TT patent/HRP20161482T1/hr unknown
- 2013-06-28 IN IN2661MUN2014 patent/IN2014MN02661A/en unknown
- 2013-06-28 RS RS20160977A patent/RS55308B1/sr unknown
- 2013-06-28 EP EP13732533.8A patent/EP2867240B1/en active Active
- 2013-06-28 US US14/411,690 patent/US9284329B2/en active Active
- 2013-06-28 PT PT137325338T patent/PT2867240T/pt unknown
- 2013-06-28 CN CN201710493350.XA patent/CN107266467A/zh active Pending
- 2013-06-28 ME MEP-2016-240A patent/ME02537B/me unknown
- 2013-06-28 ES ES13732533.8T patent/ES2603737T3/es active Active
- 2013-06-28 PL PL13732533T patent/PL2867240T3/pl unknown
- 2013-06-28 KR KR1020157002599A patent/KR101704448B1/ko active Active
- 2013-06-28 JP JP2015519153A patent/JP5972460B2/ja active Active
- 2013-06-28 CN CN201380034638.0A patent/CN104395319B/zh active Active
-
2014
- 2014-12-11 IL IL236221A patent/IL236221A/en active IP Right Grant
-
2015
- 2015-01-27 ZA ZA2015/00593A patent/ZA201500593B/en unknown
-
2016
- 2016-11-09 CY CY20161101141T patent/CY1118213T1/el unknown
- 2016-11-17 SM SM201600418T patent/SMT201600418B/it unknown
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