CN107208138A - 用于癌症预后和治疗的方法和组合物 - Google Patents

用于癌症预后和治疗的方法和组合物 Download PDF

Info

Publication number
CN107208138A
CN107208138A CN201580070110.8A CN201580070110A CN107208138A CN 107208138 A CN107208138 A CN 107208138A CN 201580070110 A CN201580070110 A CN 201580070110A CN 107208138 A CN107208138 A CN 107208138A
Authority
CN
China
Prior art keywords
expression level
cancer
cells
determined
immunotherapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580070110.8A
Other languages
English (en)
Chinese (zh)
Inventor
L·莫利内罗
P·赫格德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN107208138A publication Critical patent/CN107208138A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201580070110.8A 2014-12-30 2015-12-29 用于癌症预后和治疗的方法和组合物 Pending CN107208138A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098055P 2014-12-30 2014-12-30
US62/098,055 2014-12-30
PCT/US2015/067878 WO2016109546A2 (en) 2014-12-30 2015-12-29 Methods and compositions for prognosis and treatment of cancers

Publications (1)

Publication Number Publication Date
CN107208138A true CN107208138A (zh) 2017-09-26

Family

ID=55315702

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580070110.8A Pending CN107208138A (zh) 2014-12-30 2015-12-29 用于癌症预后和治疗的方法和组合物

Country Status (5)

Country Link
US (2) US11236394B2 (https=)
EP (1) EP3240908A2 (https=)
JP (2) JP2018503373A (https=)
CN (1) CN107208138A (https=)
WO (1) WO2016109546A2 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108823309A (zh) * 2018-06-11 2018-11-16 北京大学人民医院 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用
CN109880894A (zh) * 2019-03-05 2019-06-14 杭州西合森医学检验实验室有限公司 基于RNAseq的肿瘤免疫微环境预测模型的构建方法
CN110804642A (zh) * 2019-09-10 2020-02-18 清华大学 Gpr174免疫学功能及其用途
CN111500733A (zh) * 2020-05-27 2020-08-07 中国人民解放军军事科学院军事医学研究院 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112567052A (zh) * 2018-06-21 2021-03-26 癌症研究技术有限公司 预后和治疗响应预测方法
CN112639479A (zh) * 2018-08-29 2021-04-09 延世大学校产学协力团 提供关于对癌症免疫疗法的治疗反应的信息的方法和使用其的试剂盒
CN112739314A (zh) * 2018-08-08 2021-04-30 雪松-西奈医学中心 用于治疗癌症和自体免疫疾病的组合物和方法
CN112831562A (zh) * 2021-01-25 2021-05-25 浙江科技学院 一种用于预测肝癌患者切除术后复发风险的生物标志物组合、试剂盒
WO2022053065A1 (zh) * 2020-09-14 2022-03-17 信达生物制药(苏州)有限公司 用于预测或评估肺癌患者的生物标志物、检测方法及应用
WO2024234348A1 (en) * 2023-05-17 2024-11-21 Yanjun Wang Biomarker for immune checkpoint blockade therapy in nsclc

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit結合劑和彼之用途
US12241053B2 (en) 2015-10-09 2025-03-04 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
JP6949030B2 (ja) 2016-01-08 2021-10-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Pd−1軸結合アンタゴニスト及び抗cea/抗cd3二重特異性抗体を用いたcea陽性がんの治療方法
WO2018029124A1 (en) * 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
JP7235508B2 (ja) * 2016-11-24 2023-03-08 第一三共株式会社 Pd-1免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法
CN110662552A (zh) 2016-11-30 2020-01-07 昂科梅德制药有限公司 包含tigit结合剂的癌症治疗方法
EP3333268A1 (en) * 2016-12-09 2018-06-13 Institut Paoli Calmettes Biomarker panel for prognosis of bladder cancer
WO2018122249A1 (en) * 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018146155A1 (en) * 2017-02-07 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Tim-3 for assessing the severity of cancer
CN106950371B (zh) * 2017-02-17 2019-03-08 张灏 Pd-l1、cdk5和ctla4中的至少一种在制备肿瘤诊断试剂盒中的用途
CN110546277B (zh) 2017-03-01 2024-06-11 豪夫迈·罗氏有限公司 用于癌症的诊断和治疗方法
EP3879535B1 (en) 2017-06-13 2024-12-11 BostonGene Corporation Systems and methods for identifying cancer treatments from normalized biomarker scores
CN111164103A (zh) 2017-06-14 2020-05-15 西奈山伊坎医学院 检测和治疗对免疫疗法应答的肝细胞癌类别的方法
KR102348291B1 (ko) * 2017-06-14 2022-01-07 연세대학교 산학협력단 암 환자의 치료 반응성을 예측하는 방법
EP3652663A4 (en) * 2017-07-14 2021-04-21 Cofactor Genomics, Inc. NEXT GENERATION IMMUNONCOLOGICAL APPLICATIONS BY SEQUENCING
WO2019117132A1 (ja) * 2017-12-12 2019-06-20 地方独立行政法人神奈川県立病院機構 がん免疫療法の予後予測のためのバイオマーカー
CN112771177A (zh) * 2018-05-21 2021-05-07 纳米线科技公司 分子基因标签及其使用方法
US20210338727A1 (en) * 2018-09-13 2021-11-04 Nkarta, Inc. Natural killer cell compositions and immunotherapy methods for treating tumors
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
WO2020117952A2 (en) * 2018-12-05 2020-06-11 Genentech, Inc. Diagnostic methods and compositions for cancer immunotherapy
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
JP2022527972A (ja) * 2019-04-02 2022-06-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前悪性病変を有する患者において癌を予測及び予防する方法
EP3953712A1 (en) * 2019-04-10 2022-02-16 Universität Zürich A method for determining the likelihood of a patient being responsive to cancer immunotherapy
JP2022534967A (ja) * 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 多腫瘍遺伝子シグネチャーおよびその使用
WO2020245054A1 (en) * 2019-06-01 2020-12-10 Ares Trading S.A. Pd-1 axis binding antagonist to treat cancer with genetic mutations in specific genes
KR102042710B1 (ko) * 2019-07-02 2019-11-08 의료법인 성광의료재단 면역체크 포인트와 관련된, 난소암 진단용 바이오마커
WO2021107452A1 (ko) * 2019-11-29 2021-06-03 의료법인 성광의료재단 면역 세포 치료제에 대한 치료 반응성 예측용 바이오마커
US20210181200A1 (en) * 2019-12-17 2021-06-17 Women's College Hospital Ovarian cancer biomarker and methods of using same
GB202007099D0 (en) 2020-05-14 2020-07-01 Kymab Ltd Tumour biomarkers for immunotherapy
KR20230012559A (ko) 2020-05-19 2023-01-26 베링거 인겔하임 인터내셔날 게엠베하 암 치료를 위한 결합 분자
CN115916348A (zh) 2020-06-18 2023-04-04 基因泰克公司 使用抗tigit抗体和pd-1轴结合拮抗剂的治疗
KR102647295B1 (ko) * 2020-09-03 2024-03-14 한국과학기술연구원 암 면역 치료의 효능 예측을 위한 바이오마커 및 이의 용도
EP4247980A4 (en) * 2020-11-19 2024-10-02 Tempus AI, Inc. DETERMINATION OF CYTOTOXIC GENE SIGNATURE AND ASSOCIATED SYSTEMS AND METHODS FOR PREDICTING RESPONSE AND TREATMENT
EP4026918A1 (en) 2021-01-12 2022-07-13 Koninklijke Philips N.V. Prediction of an outcome of a colorectal cancer subject
US20240344138A1 (en) * 2021-03-25 2024-10-17 Feng Biosciences, Inc Targeted therapies in cancer
WO2022211620A1 (en) * 2021-04-01 2022-10-06 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Cd4/il-2 biomarker.
CA3226694A1 (en) 2021-07-15 2023-01-19 Katholieke Universiteit Leuven Biomarkers predicting response of breast cancer to immunotherapy
JP7480754B2 (ja) 2021-07-19 2024-05-10 トヨタ自動車株式会社 蓄電装置
CN118871463A (zh) 2021-07-28 2024-10-29 基因泰克公司 用于治疗癌症的方法和组合物
TW202321308A (zh) 2021-09-30 2023-06-01 美商建南德克公司 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法
US20260049359A1 (en) * 2022-05-19 2026-02-19 Agendia N.V. Prediction of response to immune therapy in breast cancer patients
EP4537107A2 (en) 2022-06-07 2025-04-16 Genentech, Inc. Method for determining the efficacy of a lung cancer treatment comprising an anti-pd-l1 antagonist and an anti-tigit antagonist antibody
KR20240051492A (ko) * 2022-10-13 2024-04-22 주식회사 네오셀라 대식세포 분화 및 분포에 따른 면역세포 치료제의 치료 반응성 예측 방법
IL323044A (en) 2023-03-06 2025-10-01 Genentech Inc Prognostic and therapeutic methods for non-small cell lung cancer
JPWO2024225488A1 (https=) * 2023-04-27 2024-10-31
WO2025174933A1 (en) 2024-02-14 2025-08-21 Genentech, Inc. Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484762A1 (en) * 2009-10-02 2012-08-08 Kurume University Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein
WO2014023706A1 (en) * 2012-08-06 2014-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for screening patients with a cancer
WO2014078468A2 (en) * 2012-11-15 2014-05-22 Bristol-Myers Squibb Company Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
EP0491007B1 (en) 1989-09-08 1996-03-13 The Johns Hopkins University Structural alterations of the egf receptor gene in human gliomas
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
EP0659439B1 (en) 1993-12-24 2001-10-24 MERCK PATENT GmbH Immunoconjugates
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5679683A (en) 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
PL179659B1 (pl) 1994-07-21 2000-10-31 Akzo Nobel Nv Kompozycja cyklicznych nadtlenków ketonów sluzaca do modyfikowania (ko)polimerów zwlaszcza do degradacji polipropylenu PL PL PL PL PL PL PL
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
MX9707453A (es) 1995-03-30 1997-12-31 Pfizer Derivados de quinazolina.
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
MX9800215A (es) 1995-07-06 1998-03-31 Novartis Ag Pirrolopirimidas y procesos para su preparacion.
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
HU228446B1 (en) 1996-04-12 2013-03-28 Warner Lambert Co Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof
ID19609A (id) 1996-07-13 1998-07-23 Glaxo Group Ltd Senyawa-senyawa heterosiklik
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
ATE241986T1 (de) 1997-05-06 2003-06-15 Wyeth Corp Verwendung von chinazolin verbindungen zur behandlung von polyzystischer nierenkrankheit
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
CN1278176A (zh) 1997-11-06 2000-12-27 美国氰胺公司 喹唑啉衍生物作为用于治疗结肠息肉的酪氨酸激酶抑制剂的应用
WO2000031048A1 (en) 1998-11-19 2000-06-02 Warner-Lambert Company N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases
ES2666152T3 (es) * 2009-08-13 2018-05-03 The Johns Hopkins University Métodos de modulación de la función inmunitaria con anticuerpos anti-B7-H7CR
GB0917457D0 (en) * 2009-10-06 2009-11-18 Glaxosmithkline Biolog Sa Method
WO2011094483A2 (en) * 2010-01-29 2011-08-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Immune gene signatures in cancer
CA2796464C (en) 2010-04-16 2021-08-03 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
US20120258878A1 (en) * 2010-08-04 2012-10-11 Med Biogene Inc. Prognostic gene signatures for non-small cell lung cancer
JP6238459B2 (ja) 2011-08-01 2017-11-29 ジェネンテック, インコーポレイテッド Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
EP2615181A1 (en) * 2012-01-10 2013-07-17 Universite Joseph Fourier - Grenoble 1 Cyclon expression for the identification and control of cancer cells
CN113967253A (zh) * 2012-05-15 2022-01-25 百时美施贵宝公司 通过破坏pd-1/pd-l1信号传输的免疫治疗

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484762A1 (en) * 2009-10-02 2012-08-08 Kurume University Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein
WO2014023706A1 (en) * 2012-08-06 2014-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for screening patients with a cancer
WO2014078468A2 (en) * 2012-11-15 2014-05-22 Bristol-Myers Squibb Company Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
孙晓杰等: "《肿瘤分子诊断与靶向治疗》", 31 July 2009 *
张镭: "抗肿瘤化疗对肺癌患者免疫格局与功能的改变及意义", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 *
汤钊猷: "《现代肿瘤学》", 31 July 2011 *
石一复等: "《卵巢疾病》", 30 November 2014 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108823309B (zh) * 2018-06-11 2021-11-30 北京大学人民医院 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用
CN108823309A (zh) * 2018-06-11 2018-11-16 北京大学人民医院 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用
CN112567052A (zh) * 2018-06-21 2021-03-26 癌症研究技术有限公司 预后和治疗响应预测方法
CN112739314A (zh) * 2018-08-08 2021-04-30 雪松-西奈医学中心 用于治疗癌症和自体免疫疾病的组合物和方法
CN112639479A (zh) * 2018-08-29 2021-04-09 延世大学校产学协力团 提供关于对癌症免疫疗法的治疗反应的信息的方法和使用其的试剂盒
US12480949B2 (en) 2018-08-29 2025-11-25 Industry-Academic Cooperation Foundation, Yonsei University Methods for treating non-small lung cancer and for preparing a sample
CN109880894A (zh) * 2019-03-05 2019-06-14 杭州西合森医学检验实验室有限公司 基于RNAseq的肿瘤免疫微环境预测模型的构建方法
CN110804642A (zh) * 2019-09-10 2020-02-18 清华大学 Gpr174免疫学功能及其用途
CN110804642B (zh) * 2019-09-10 2022-06-21 清华大学 Gpr174免疫学功能及其用途
CN111500733A (zh) * 2020-05-27 2020-08-07 中国人民解放军军事科学院军事医学研究院 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物
WO2022053065A1 (zh) * 2020-09-14 2022-03-17 信达生物制药(苏州)有限公司 用于预测或评估肺癌患者的生物标志物、检测方法及应用
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112530581B (zh) * 2020-12-03 2023-11-21 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112831562A (zh) * 2021-01-25 2021-05-25 浙江科技学院 一种用于预测肝癌患者切除术后复发风险的生物标志物组合、试剂盒
WO2024234348A1 (en) * 2023-05-17 2024-11-21 Yanjun Wang Biomarker for immune checkpoint blockade therapy in nsclc

Also Published As

Publication number Publication date
WO2016109546A2 (en) 2016-07-07
US12385098B2 (en) 2025-08-12
JP7325463B2 (ja) 2023-08-14
US20220298576A1 (en) 2022-09-22
JP2021118684A (ja) 2021-08-12
US11236394B2 (en) 2022-02-01
EP3240908A2 (en) 2017-11-08
JP2018503373A (ja) 2018-02-08
US20170260594A1 (en) 2017-09-14
WO2016109546A3 (en) 2016-09-01

Similar Documents

Publication Publication Date Title
US12385098B2 (en) Methods and compositions for prognosis and treatment of cancers
JP2024053048A (ja) 分子遺伝子シグネチャーとその使用方法
RU2710735C2 (ru) Композиции и способы лечения и диагностики резистентного к химиотерапии рака
US12174193B2 (en) Agents and methods for predicting response to therapy
US12183434B2 (en) Diagnostic and therapeutic methods for cancer
TW202027784A (zh) 腎癌之診斷及治療方法
CN107106688A (zh) 预测对vegf拮抗剂的响应
JP7520389B2 (ja) T細胞機能を評価して治療法に対する応答を予測するための方法および薬剤
WO2020223233A1 (en) Prognostic and therapeutic methods for colorectal cancer
HK1244302A1 (en) Methods and compositions for prognosis and treatment of cancers

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1244302

Country of ref document: HK

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20170926

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1244302

Country of ref document: HK