CN107208138A - 用于癌症预后和治疗的方法和组合物 - Google Patents

用于癌症预后和治疗的方法和组合物 Download PDF

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CN107208138A
CN107208138A CN201580070110.8A CN201580070110A CN107208138A CN 107208138 A CN107208138 A CN 107208138A CN 201580070110 A CN201580070110 A CN 201580070110A CN 107208138 A CN107208138 A CN 107208138A
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cancer
cells
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immunotherapy
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L·莫利内罗
P·赫格德
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F Hoffmann La Roche AG
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Immunology (AREA)
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  • Genetics & Genomics (AREA)
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  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CN201580070110.8A 2014-12-30 2015-12-29 用于癌症预后和治疗的方法和组合物 Pending CN107208138A (zh)

Applications Claiming Priority (3)

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US201462098055P 2014-12-30 2014-12-30
US62/098,055 2014-12-30
PCT/US2015/067878 WO2016109546A2 (en) 2014-12-30 2015-12-29 Methods and compositions for prognosis and treatment of cancers

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US (2) US11236394B2 (https=)
EP (1) EP3240908A2 (https=)
JP (2) JP2018503373A (https=)
CN (1) CN107208138A (https=)
WO (1) WO2016109546A2 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108823309A (zh) * 2018-06-11 2018-11-16 北京大学人民医院 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用
CN109880894A (zh) * 2019-03-05 2019-06-14 杭州西合森医学检验实验室有限公司 基于RNAseq的肿瘤免疫微环境预测模型的构建方法
CN110804642A (zh) * 2019-09-10 2020-02-18 清华大学 Gpr174免疫学功能及其用途
CN111500733A (zh) * 2020-05-27 2020-08-07 中国人民解放军军事科学院军事医学研究院 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112567052A (zh) * 2018-06-21 2021-03-26 癌症研究技术有限公司 预后和治疗响应预测方法
CN112639479A (zh) * 2018-08-29 2021-04-09 延世大学校产学协力团 提供关于对癌症免疫疗法的治疗反应的信息的方法和使用其的试剂盒
CN112739314A (zh) * 2018-08-08 2021-04-30 雪松-西奈医学中心 用于治疗癌症和自体免疫疾病的组合物和方法
CN112831562A (zh) * 2021-01-25 2021-05-25 浙江科技学院 一种用于预测肝癌患者切除术后复发风险的生物标志物组合、试剂盒
WO2022053065A1 (zh) * 2020-09-14 2022-03-17 信达生物制药(苏州)有限公司 用于预测或评估肺癌患者的生物标志物、检测方法及应用
WO2024234348A1 (en) * 2023-05-17 2024-11-21 Yanjun Wang Biomarker for immune checkpoint blockade therapy in nsclc

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
US12241053B2 (en) 2015-10-09 2025-03-04 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
KR20180097615A (ko) 2016-01-08 2018-08-31 에프. 호프만-라 로슈 아게 Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법
WO2018029124A1 (en) * 2016-08-08 2018-02-15 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
JP7235508B2 (ja) * 2016-11-24 2023-03-08 第一三共株式会社 Ｐｄ－１免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法
MX2019006072A (es) 2016-11-30 2019-08-14 Oncomed Pharm Inc Metodos para tratamiento de cancer que comprenden agentes de enlace al inmunoreceptor de celulas t con dominios ige itim (tigit).
EP3333268A1 (en) * 2016-12-09 2018-06-13 Institut Paoli Calmettes Biomarker panel for prognosis of bladder cancer
WO2018122249A1 (en) * 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
JP7206203B2 (ja) * 2017-02-07 2023-01-17 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル がんの重症度を評価するためのｔｉｍ－３
CN106950371B (zh) * 2017-02-17 2019-03-08 张灏 Pd-l1、cdk5和ctla4中的至少一种在制备肿瘤诊断试剂盒中的用途
TW201837467A (zh) 2017-03-01 2018-10-16 美商建南德克公司 用於癌症之診斷及治療方法
GB202209539D0 (en) 2017-06-13 2022-08-10 Bostongene Corp Systems and methods for identifying cancer treatments from normalized biomarker scores
CN111164103A (zh) * 2017-06-14 2020-05-15 西奈山伊坎医学院 检测和治疗对免疫疗法应答的肝细胞癌类别的方法
KR102348291B1 (ko) * 2017-06-14 2022-01-07 연세대학교 산학협력단 암 환자의 치료 반응성을 예측하는 방법
CA3069828A1 (en) * 2017-07-14 2019-01-17 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
WO2019117132A1 (ja) * 2017-12-12 2019-06-20 地方独立行政法人神奈川県立病院機構 がん免疫療法の予後予測のためのバイオマーカー
JP2021524744A (ja) * 2018-05-21 2021-09-16 ナノストリング テクノロジーズ，インコーポレイティド 分子遺伝子シグネチャーとその使用方法
AU2019337603B2 (en) * 2018-09-13 2026-03-05 Nkarta, Inc. Natural killer cell compositions and immunotherapy methods for treating tumors
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP4198057A1 (en) * 2018-12-05 2023-06-21 F. Hoffmann-La Roche AG Diagnostic methods and compositions for cancer immunotherapy
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
EP3947737A2 (en) * 2019-04-02 2022-02-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020207771A1 (en) * 2019-04-10 2020-10-15 Universität Zürich A method for determining the likelihood of a patient being responsive to cancer immunotherapy
US20220363760A1 (en) * 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
EP3976040A1 (en) * 2019-06-01 2022-04-06 Ares Trading S.A. Pd-1 axis binding antagonist to treat cancer with genetic mutations in specific genes
KR102042710B1 (ko) * 2019-07-02 2019-11-08 의료법인 성광의료재단 면역체크 포인트와 관련된, 난소암 진단용 바이오마커
JP2023504444A (ja) * 2019-11-29 2023-02-03 スンクワン メディカル ファウンデーション 免疫治療剤に係わる治療反応性予測用バイオマーカー
US20210181200A1 (en) * 2019-12-17 2021-06-17 Women's College Hospital Ovarian cancer biomarker and methods of using same
GB202007099D0 (en) 2020-05-14 2020-07-01 Kymab Ltd Tumour biomarkers for immunotherapy
WO2021236658A1 (en) 2020-05-19 2021-11-25 Boehringer Ingelheim International Gmbh Binding molecules for the treatment of cancer
KR20230024368A (ko) 2020-06-18 2023-02-20 제넨테크, 인크. 항-tigit 항체 및 pd-1 축 결합 길항제를 사용한 치료
KR102647295B1 (ko) * 2020-09-03 2024-03-14 한국과학기술연구원 암 면역 치료의 효능 예측을 위한 바이오마커 및 이의 용도
WO2022109607A2 (en) * 2020-11-19 2022-05-27 Tempus Labs, Inc. Determination of cytotoxic gene signature and associated systems and methods for response prediction and treatment
EP4026918A1 (en) * 2021-01-12 2022-07-13 Koninklijke Philips N.V. Prediction of an outcome of a colorectal cancer subject
IL306090A (en) * 2021-03-25 2023-11-01 Oncxerna Therapeutics Inc Targeted cancer treatments
WO2022211620A1 (en) * 2021-04-01 2022-10-06 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Cd4/il-2 biomarker.
WO2023285521A1 (en) 2021-07-15 2023-01-19 Vib Vzw Biomarkers predicting response of breast cancer to immunotherapy
JP7480754B2 (ja) 2021-07-19 2024-05-10 トヨタ自動車株式会社 蓄電装置
WO2023010094A2 (en) 2021-07-28 2023-02-02 Genentech, Inc. Methods and compositions for treating cancer
WO2023056403A1 (en) 2021-09-30 2023-04-06 Genentech, Inc. Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
US20260049359A1 (en) * 2022-05-19 2026-02-19 Agendia N.V. Prediction of response to immune therapy in breast cancer patients
KR20250022049A (ko) 2022-06-07 2025-02-14 제넨테크, 인크. 항-pd-l1 길항제 및 항-tigit 길항제 항체를 포함하는, 폐암 치료의 효율을 결정하는 방법
KR20240051492A (ko) * 2022-10-13 2024-04-22 주식회사 네오셀라 대식세포 분화 및 분포에 따른 면역세포 치료제의 치료 반응성 예측 방법
CN120826478A (zh) 2023-03-06 2025-10-21 基因泰克公司 用于非小细胞肺癌的预后和治疗方法
WO2024225488A1 (ja) * 2023-04-27 2024-10-31 株式会社リプロセル 抗ｐｄ－１抗体療法に応答性である候補がん患者を同定する方法
WO2025174933A1 (en) 2024-02-14 2025-08-21 Genentech, Inc. Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484762A1 (en) * 2009-10-02 2012-08-08 Kurume University Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein
WO2014023706A1 (en) * 2012-08-06 2014-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for screening patients with a cancer
WO2014078468A2 (en) * 2012-11-15 2014-05-22 Bristol-Myers Squibb Company Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
EP0491007B1 (en) 1989-09-08 1996-03-13 The Johns Hopkins University Structural alterations of the egf receptor gene in human gliomas
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
DE69428764T2 (de) 1993-12-24 2002-06-20 Merck Patent Gmbh Immunokonjugate
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
WO1996003397A1 (en) 1994-07-21 1996-02-08 Akzo Nobel N.V. Cyclic ketone peroxide formulations
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
JPH11507535A (ja) 1995-06-07 1999-07-06 イムクローン システムズ インコーポレイテッド 腫瘍の成長を抑制する抗体および抗体フラグメント類
SI9620103A (sl) 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
EA001595B1 (ru) 1996-04-12 2001-06-25 Варнер-Ламберт Компани Необратимые ингибиторы тирозинкиназ
AR007857A1 (es) 1996-07-13 1999-11-24 Glaxo Group Ltd Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen.
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
WO1998050038A1 (en) 1997-05-06 1998-11-12 American Cyanamid Company Use of quinazoline compounds for the treatment of polycystic kidney disease
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
BR9814116A (pt) 1997-11-06 2000-10-03 American Cyanamid Co Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico
EA003786B1 (ru) 1998-11-19 2003-10-30 Варнер Ламберт Компани N-[4-(3-хлор-4-фторфениламино)-7-(3-морфолин-4-илпропокси)хиназолин-6-ил]акриламид - необратимый ингибитор тирозинкиназ
CA2769822C (en) * 2009-08-13 2019-02-19 The Johns Hopkins University Methods of modulating immune function
GB0917457D0 (en) * 2009-10-06 2009-11-18 Glaxosmithkline Biolog Sa Method
US9404926B2 (en) * 2010-01-29 2016-08-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Immune gene signatures in cancer
US8802438B2 (en) 2010-04-16 2014-08-12 Children's Medical Center Corporation Compositions, kits, and methods for making induced pluripotent stem cells using synthetic modified RNAs
US20120258878A1 (en) * 2010-08-04 2012-10-11 Med Biogene Inc. Prognostic gene signatures for non-small cell lung cancer
MX368257B (es) * 2011-08-01 2019-09-26 Genentech Inc Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer.
EP2615181A1 (en) * 2012-01-10 2013-07-17 Universite Joseph Fourier - Grenoble 1 Cyclon expression for the identification and control of cancer cells
HK1203971A1 (en) * 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2484762A1 (en) * 2009-10-02 2012-08-08 Kurume University Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein
WO2014023706A1 (en) * 2012-08-06 2014-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for screening patients with a cancer
WO2014078468A2 (en) * 2012-11-15 2014-05-22 Bristol-Myers Squibb Company Biomarkers for predicting clinical response of cancer patients to treatment with immunotherapeutic agent

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
孙晓杰等: "《肿瘤分子诊断与靶向治疗》", 31 July 2009 *
张镭: "抗肿瘤化疗对肺癌患者免疫格局与功能的改变及意义", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 *
汤钊猷: "《现代肿瘤学》", 31 July 2011 *
石一复等: "《卵巢疾病》", 30 November 2014 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108823309B (zh) * 2018-06-11 2021-11-30 北京大学人民医院 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用
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CN112567052A (zh) * 2018-06-21 2021-03-26 癌症研究技术有限公司 预后和治疗响应预测方法
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CN112639479A (zh) * 2018-08-29 2021-04-09 延世大学校产学协力团 提供关于对癌症免疫疗法的治疗反应的信息的方法和使用其的试剂盒
US12480949B2 (en) 2018-08-29 2025-11-25 Industry-Academic Cooperation Foundation, Yonsei University Methods for treating non-small lung cancer and for preparing a sample
CN109880894A (zh) * 2019-03-05 2019-06-14 杭州西合森医学检验实验室有限公司 基于RNAseq的肿瘤免疫微环境预测模型的构建方法
CN110804642A (zh) * 2019-09-10 2020-02-18 清华大学 Gpr174免疫学功能及其用途
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CN111500733A (zh) * 2020-05-27 2020-08-07 中国人民解放军军事科学院军事医学研究院 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物
WO2022053065A1 (zh) * 2020-09-14 2022-03-17 信达生物制药(苏州)有限公司 用于预测或评估肺癌患者的生物标志物、检测方法及应用
CN112530581A (zh) * 2020-12-03 2021-03-19 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112530581B (zh) * 2020-12-03 2023-11-21 安徽医科大学第一附属医院 一种前列腺癌患者的免疫分子分类系统及其应用
CN112831562A (zh) * 2021-01-25 2021-05-25 浙江科技学院 一种用于预测肝癌患者切除术后复发风险的生物标志物组合、试剂盒
WO2024234348A1 (en) * 2023-05-17 2024-11-21 Yanjun Wang Biomarker for immune checkpoint blockade therapy in nsclc

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