CN1071292C - 用于生产对映体纯的氮杂环丁烷-2-羧酸的改进的方法 - Google Patents

用于生产对映体纯的氮杂环丁烷-2-羧酸的改进的方法 Download PDF

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Publication number
CN1071292C
CN1071292C CN97194111A CN97194111A CN1071292C CN 1071292 C CN1071292 C CN 1071292C CN 97194111 A CN97194111 A CN 97194111A CN 97194111 A CN97194111 A CN 97194111A CN 1071292 C CN1071292 C CN 1071292C
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CN
China
Prior art keywords
carboxylic acid
azetidine
azeoh
acid
tartrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97194111A
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English (en)
Chinese (zh)
Other versions
CN1216972A (zh
Inventor
P·巴斯
A·普芬宁格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
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Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CN1216972A publication Critical patent/CN1216972A/zh
Application granted granted Critical
Publication of CN1071292C publication Critical patent/CN1071292C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN97194111A 1996-04-26 1997-04-22 用于生产对映体纯的氮杂环丁烷-2-羧酸的改进的方法 Expired - Fee Related CN1071292C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE96016001 1996-04-26
SE9601600-1 1996-04-26
SE9601600A SE9601600D0 (sv) 1996-04-26 1996-04-26 Improved process

Publications (2)

Publication Number Publication Date
CN1216972A CN1216972A (zh) 1999-05-19
CN1071292C true CN1071292C (zh) 2001-09-19

Family

ID=20402360

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97194111A Expired - Fee Related CN1071292C (zh) 1996-04-26 1997-04-22 用于生产对映体纯的氮杂环丁烷-2-羧酸的改进的方法

Country Status (32)

Country Link
US (1) US6143903A (enExample)
EP (1) EP0906255B1 (enExample)
JP (2) JP2000509068A (enExample)
KR (1) KR100447072B1 (enExample)
CN (1) CN1071292C (enExample)
AR (1) AR006639A1 (enExample)
AT (1) ATE200889T1 (enExample)
AU (1) AU713519B2 (enExample)
BR (1) BR9708872A (enExample)
CA (1) CA2253711C (enExample)
CZ (1) CZ339998A3 (enExample)
DE (1) DE69704708T2 (enExample)
DK (1) DK0906255T3 (enExample)
EE (1) EE9800365A (enExample)
EG (1) EG20975A (enExample)
ES (1) ES2158557T3 (enExample)
GR (1) GR3036303T3 (enExample)
HU (1) HUP9901665A3 (enExample)
ID (1) ID16840A (enExample)
IL (1) IL126717A (enExample)
IN (1) IN186439B (enExample)
IS (1) IS4860A (enExample)
MY (1) MY132450A (enExample)
NO (1) NO310404B1 (enExample)
NZ (1) NZ332155A (enExample)
PL (1) PL329685A1 (enExample)
PT (1) PT906255E (enExample)
SE (1) SE9601600D0 (enExample)
SK (1) SK140898A3 (enExample)
TR (1) TR199802146T2 (enExample)
WO (1) WO1997041084A1 (enExample)
ZA (1) ZA973156B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1308519B1 (en) * 1997-01-24 2006-04-19 Sumitomo Chemical Company, Limited Process for improving optical purity of azetidine-2-carboxylic acid
SE9802939D0 (sv) 1998-09-01 1998-09-01 Astra Ab New process
SE9901712D0 (sv) 1999-05-11 1999-05-11 Astra Ab New process
WO2005103005A1 (ja) * 2004-04-26 2005-11-03 Astellas Pharma Inc. β－ピリジルアラニンの光学活性体の選択的製造方法
CN102143928A (zh) * 2008-09-05 2011-08-03 马克斯普朗克科学促进协会 利用两个连续的结晶步骤对化合物形成的手性体系进行对映体拆分的方法
JP2013241339A (ja) * 2010-09-09 2013-12-05 Mitsubishi Gas Chemical Co Inc 光学活性アミノ酸の製造方法
JP2013241338A (ja) * 2010-09-09 2013-12-05 Mitsubishi Gas Chemical Co Inc 光学活性２−アミノ酪酸の製造方法
CN103204783B (zh) * 2013-04-18 2015-09-02 张家港市华昌药业有限公司 一种d-赖氨酸盐酸盐的制备方法
WO2016021711A1 (ja) * 2014-08-07 2016-02-11 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416736A2 (en) * 1989-07-31 1991-03-13 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795874A (fr) * 1972-02-25 1973-08-23 Glaxo Lab Ltd Procede de preparation d'esters optiquement actifs d'alpha-amino-acides
JPS5139219B2 (enExample) * 1972-06-08 1976-10-26
US4072698A (en) * 1976-12-02 1978-02-07 The Upjohn Company Resolution of aminonitriles
JPS56104866A (en) * 1980-01-24 1981-08-20 Mitsubishi Chem Ind Ltd Production of (2r,4r)-4-alkyl-2-piperidinecarboxylic acid or its l-tartarate salt
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
EP0499376A1 (en) * 1991-01-31 1992-08-19 Hoechst Celanese Corporation Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof
GB9420246D0 (en) * 1994-10-07 1994-11-23 Chiroscience Ltd Asymmetric crystallisation
IN187238B (enExample) * 1995-06-30 2002-03-09 Astra Ab
EP0827954B1 (en) * 1996-09-06 2003-06-04 Sumitomo Chemical Company Limited Process for producing optically active azetidine-2-carboxylic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416736A2 (en) * 1989-07-31 1991-03-13 Eli Lilly And Company Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one

Also Published As

Publication number Publication date
CA2253711C (en) 2005-08-23
CN1216972A (zh) 1999-05-19
EP0906255B1 (en) 2001-05-02
PL329685A1 (en) 1999-04-12
EP0906255A1 (en) 1999-04-07
IS4860A (is) 1998-10-06
NO310404B1 (no) 2001-07-02
SE9601600D0 (sv) 1996-04-26
ES2158557T3 (es) 2001-09-01
NO984681D0 (no) 1998-10-07
AU2719497A (en) 1997-11-19
MY132450A (en) 2007-10-31
IL126717A0 (en) 1999-08-17
EG20975A (en) 2000-08-30
KR20000065019A (ko) 2000-11-06
ZA973156B (en) 1997-11-06
TR199802146T2 (xx) 1999-01-18
JP2000509068A (ja) 2000-07-18
ID16840A (id) 1997-11-13
IN186439B (enExample) 2001-09-01
CZ339998A3 (cs) 1999-03-17
IL126717A (en) 2002-11-10
DK0906255T3 (da) 2001-08-13
CA2253711A1 (en) 1997-11-06
WO1997041084A1 (en) 1997-11-06
US6143903A (en) 2000-11-07
DE69704708D1 (de) 2001-06-07
EE9800365A (et) 1999-04-15
JP2009120611A (ja) 2009-06-04
BR9708872A (pt) 1999-08-03
NO984681L (no) 1998-10-07
SK140898A3 (en) 1999-05-07
ATE200889T1 (de) 2001-05-15
NZ332155A (en) 2000-07-28
KR100447072B1 (ko) 2004-10-14
PT906255E (pt) 2001-10-30
AU713519B2 (en) 1999-12-02
GR3036303T3 (en) 2001-10-31
HUP9901665A2 (hu) 1999-09-28
HUP9901665A3 (en) 1999-11-29
AR006639A1 (es) 1999-09-08
DE69704708T2 (de) 2001-12-06

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Granted publication date: 20010919

Termination date: 20110422