CN107106559A - 自分泌运动因子的取代的螺环抑制剂 - Google Patents
自分泌运动因子的取代的螺环抑制剂 Download PDFInfo
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- CN107106559A CN107106559A CN201580028170.3A CN201580028170A CN107106559A CN 107106559 A CN107106559 A CN 107106559A CN 201580028170 A CN201580028170 A CN 201580028170A CN 107106559 A CN107106559 A CN 107106559A
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108456208A (zh) * | 2017-02-22 | 2018-08-28 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
| CN111148746A (zh) * | 2017-09-29 | 2020-05-12 | 武田药品工业株式会社 | 杂环化合物 |
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| PL2900669T3 (pl) | 2012-09-25 | 2020-01-31 | F. Hoffmann-La Roche Ag | Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| HUE036117T2 (hu) | 2013-11-26 | 2018-06-28 | Hoffmann La Roche | Oktahidro-ciklobuta[1,2-C;3,4-C']dipirrol származékok, mint autotaxin inhibitorok |
| EA037928B1 (ru) | 2014-03-26 | 2021-06-08 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物 |
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| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
| CN107922412B (zh) | 2015-09-24 | 2021-02-23 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
| KR20180054830A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
| EP3353178B1 (en) | 2015-09-24 | 2021-07-14 | F. Hoffmann-La Roche AG | Bicyclic compounds as dual atx/ca inhibitors |
| MX2017015034A (es) | 2015-09-24 | 2018-04-13 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca). |
| EP3423057A1 (en) | 2016-03-04 | 2019-01-09 | Gilead Sciences, Inc. | Compositions and combinations of autotaxin inhibitors |
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| EP3596060B1 (en) | 2017-03-16 | 2023-09-20 | F. Hoffmann-La Roche AG | New bicyclic compounds as atx inhibitors |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| WO2020051230A1 (en) * | 2018-09-04 | 2020-03-12 | X-Rx, Inc. | Amorphous pharmaceutical compositions and uses thereof |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
| EP4196478A1 (en) * | 2020-08-14 | 2023-06-21 | Novartis AG | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
| UY39516A (es) | 2020-11-13 | 2022-05-31 | H Lundbeck As | Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensión |
| CN112675308B (zh) * | 2020-12-09 | 2023-05-05 | 中国人民解放军军事科学院军事医学研究院 | 抑制enpp2基因和/或蛋白表达的物质在制备治疗多发性骨髓瘤的药物中的应用 |
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| CN108456208A (zh) * | 2017-02-22 | 2018-08-28 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
| CN108456208B (zh) * | 2017-02-22 | 2021-04-16 | 广州市恒诺康医药科技有限公司 | 氮杂螺环类化合物及其制备方法和应用 |
| CN111148746A (zh) * | 2017-09-29 | 2020-05-12 | 武田药品工业株式会社 | 杂环化合物 |
| US11274101B2 (en) | 2017-09-29 | 2022-03-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN111148746B (zh) * | 2017-09-29 | 2022-08-05 | 武田药品工业株式会社 | 杂环化合物 |
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| CU24442B1 (es) | 2019-09-04 |
| CL2016002516A1 (es) | 2017-05-12 |
| AU2019264641A1 (en) | 2019-12-05 |
| MD20160116A2 (ro) | 2017-04-30 |
| JP2020040960A (ja) | 2020-03-19 |
| PE20170206A1 (es) | 2017-04-09 |
| US20180282332A1 (en) | 2018-10-04 |
| IL248050A0 (en) | 2016-11-30 |
| EA201691840A1 (ru) | 2017-03-31 |
| KR20160133004A (ko) | 2016-11-21 |
| US10233182B2 (en) | 2019-03-19 |
| US20170166568A1 (en) | 2017-06-15 |
| PH12016501922A1 (en) | 2016-12-19 |
| AP2016009496A0 (en) | 2016-10-31 |
| EP3125895A1 (en) | 2017-02-08 |
| WO2015154023A1 (en) | 2015-10-08 |
| MX2016013049A (es) | 2017-04-27 |
| CR20160496A (es) | 2017-01-02 |
| ECSP16084293A (es) | 2017-01-31 |
| US20190225611A1 (en) | 2019-07-25 |
| CU20160150A7 (es) | 2017-02-02 |
| AU2015240519B2 (en) | 2019-08-15 |
| JP6616821B2 (ja) | 2019-12-04 |
| CA2943874A1 (en) | 2015-10-08 |
| JP2017513932A (ja) | 2017-06-01 |
| US10011601B2 (en) | 2018-07-03 |
| DOP2016000270A (es) | 2016-12-15 |
| EP3125895A4 (en) | 2017-08-30 |
| AU2015240519A1 (en) | 2016-10-20 |
| SG11201607920RA (en) | 2016-10-28 |
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