UY39516A - Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensión - Google Patents
Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensiónInfo
- Publication number
- UY39516A UY39516A UY0001039516A UY39516A UY39516A UY 39516 A UY39516 A UY 39516A UY 0001039516 A UY0001039516 A UY 0001039516A UY 39516 A UY39516 A UY 39516A UY 39516 A UY39516 A UY 39516A
- Authority
- UY
- Uruguay
- Prior art keywords
- composition
- treatment
- hypertension
- prevention
- vascular disease
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 206010020772 Hypertension Diseases 0.000 title 2
- 230000002265 prevention Effects 0.000 title 2
- 208000019553 vascular disease Diseases 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102100029814 Monoglyceride lipase Human genes 0.000 abstract 2
- 101710116393 Monoglyceride lipase Proteins 0.000 abstract 2
- JORVTLIDSCTEHS-UHFFFAOYSA-N O=C(N1CCC2(CC2)CC1)OC(C(F)(F)F)C(F)(F)F Chemical class O=C(N1CCC2(CC2)CC1)OC(C(F)(F)F)C(F)(F)F JORVTLIDSCTEHS-UHFFFAOYSA-N 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
En la presente se proporcionan compuestos de 6-azaespiro[2.5]octano-6-carboxilato de 1,1,1,3,3,3-hexafluoropropan-2-ilo sustituidos y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos y composiciones proporcionados en la presente son útiles como inhibidores de MAGL. Además, los compuestos y composiciones y proporcionados en la presente son útiles para el tratamiento de enfermedades y trastornos que se benefician de la inhibición de MAGL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063113662P | 2020-11-13 | 2020-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY39516A true UY39516A (es) | 2022-05-31 |
Family
ID=78709459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001039516A UY39516A (es) | 2020-11-13 | 2021-11-11 | Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensión |
Country Status (17)
Country | Link |
---|---|
US (2) | US11434222B2 (es) |
EP (1) | EP4244208A1 (es) |
JP (1) | JP2023549051A (es) |
KR (1) | KR20230107225A (es) |
CN (1) | CN116547274A (es) |
AR (1) | AR124057A1 (es) |
AU (1) | AU2021379081A1 (es) |
CA (1) | CA3196119A1 (es) |
CL (1) | CL2023001339A1 (es) |
CO (1) | CO2023004649A2 (es) |
CR (1) | CR20230203A (es) |
DO (1) | DOP2023000086A (es) |
IL (1) | IL301818A (es) |
MX (1) | MX2023005576A (es) |
TW (1) | TW202229255A (es) |
UY (1) | UY39516A (es) |
WO (1) | WO2022101412A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
WO2023213854A1 (en) * | 2022-05-04 | 2023-11-09 | H. Lundbeck A/S | Crystalline form of 1,1,1,3,3,3-hexafluoropropan-2-yl (s)-1-(pyridazin-3-ylcarbamoyl)-6 azaspiro[2.5]octane-6-carboxylate as monoacylglycerol lipase inhibitor. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2008023720A1 (ja) | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
PL2800565T3 (pl) | 2012-01-06 | 2020-09-21 | Lundbeck La Jolla Research Center, Inc. | Związki karbaminianowe i sposoby ich wytwarzania oraz zastosowanie |
LT2900669T (lt) | 2012-09-25 | 2019-11-11 | Hoffmann La Roche | Heksahidropirol[3,4-c]pirolo dariniai ir susiję junginai kaip autotaksino (atx) inhibitoriai ir kaip lizofosfatidinės rūgšties (lpa) gamybos inhibitoriai, skirti gydyti pvz., inkstų ligas |
US9828379B2 (en) | 2013-07-03 | 2017-11-28 | Abide Therapeutics, Inc. | Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof |
CA2943874A1 (en) | 2014-04-04 | 2015-10-08 | X-Rx, Inc. | Substituted spirocyclic inhibitors of autotaxin |
JP2018513119A (ja) | 2015-03-18 | 2018-05-24 | アビデ セラピューティクス,インク. | ピペラジンカルバメート、およびピペラジンカルバメートを製造ならびに使用する方法 |
JP6832914B2 (ja) | 2015-07-31 | 2021-02-24 | ファイザー・インク | Magl阻害薬としての1,1,1−トリフルオロ−3−ヒドロキシプロパン−2−イルカルバマート誘導体および1,1,1−トリフルオロ−4−ヒドロキシブタン−2−イルカルバマート誘導体 |
MY194647A (en) | 2016-03-31 | 2022-12-09 | Takeda Pharmaceuticals Co | Heterocyclic compound |
US10030020B2 (en) | 2016-05-12 | 2018-07-24 | Abide Therapeutics, Inc. | Spirocycle compounds and methods of making and using same |
JOP20190105A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
AU2018326497A1 (en) | 2017-08-29 | 2020-02-20 | H. Lundbeck A/S. | Spirocycle compounds and methods of making and using same |
BR112020004101A2 (pt) | 2017-08-29 | 2020-09-24 | Lundbeck La Jolla Research Center, Inc. | compostos de espirociclo e métodos para produzir e usar os mesmos |
-
2021
- 2021-11-10 TW TW110141858A patent/TW202229255A/zh unknown
- 2021-11-11 US US17/524,632 patent/US11434222B2/en active Active
- 2021-11-11 UY UY0001039516A patent/UY39516A/es unknown
- 2021-11-12 CR CR20230203A patent/CR20230203A/es unknown
- 2021-11-12 WO PCT/EP2021/081522 patent/WO2022101412A1/en active Application Filing
- 2021-11-12 CA CA3196119A patent/CA3196119A1/en active Pending
- 2021-11-12 MX MX2023005576A patent/MX2023005576A/es unknown
- 2021-11-12 KR KR1020237015365A patent/KR20230107225A/ko unknown
- 2021-11-12 CN CN202180073621.0A patent/CN116547274A/zh active Pending
- 2021-11-12 IL IL301818A patent/IL301818A/en unknown
- 2021-11-12 JP JP2023524567A patent/JP2023549051A/ja active Pending
- 2021-11-12 AU AU2021379081A patent/AU2021379081A1/en active Pending
- 2021-11-12 EP EP21811018.7A patent/EP4244208A1/en active Pending
- 2021-11-12 US US18/252,611 patent/US20240018120A1/en active Pending
- 2021-11-12 AR ARP210103142A patent/AR124057A1/es unknown
-
2023
- 2023-04-14 CO CONC2023/0004649A patent/CO2023004649A2/es unknown
- 2023-05-02 DO DO2023000086A patent/DOP2023000086A/es unknown
- 2023-05-09 CL CL2023001339A patent/CL2023001339A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2023005576A (es) | 2023-05-29 |
US20220153721A1 (en) | 2022-05-19 |
WO2022101412A1 (en) | 2022-05-19 |
DOP2023000086A (es) | 2023-06-30 |
AR124057A1 (es) | 2023-02-08 |
TW202229255A (zh) | 2022-08-01 |
IL301818A (en) | 2023-06-01 |
CO2023004649A2 (es) | 2023-05-08 |
US20240018120A1 (en) | 2024-01-18 |
CR20230203A (es) | 2023-06-14 |
JP2023549051A (ja) | 2023-11-22 |
AU2021379081A1 (en) | 2023-05-18 |
CA3196119A1 (en) | 2022-05-19 |
CN116547274A (zh) | 2023-08-04 |
US11434222B2 (en) | 2022-09-06 |
CL2023001339A1 (es) | 2023-10-20 |
KR20230107225A (ko) | 2023-07-14 |
EP4244208A1 (en) | 2023-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2023001738A1 (es) | Inhibidores de prmt5 | |
CL2019000221A1 (es) | Compuestos de tiazolo-piridina sustituida como inhibidores de malt1. | |
UY39516A (es) | Composición para el tratamiento de una enfermedad vascular, composición para la prevención de una enfermedad vascular, composición para el tratamiento de la hipertensión, y composición para la prevención de la hipertensión | |
UY39149A (es) | Compuestos y métodos para el tratamiento de covid-19 | |
AR105808A1 (es) | Compuestos de amida para el tratamiento de trastornos médicos | |
CY1115289T1 (el) | Μεθοδοι αγωγης εναντι ασθενειας που σχετιζεται με φλεγμονη | |
CO2024000588A2 (es) | Composiciones y métodos para la inhibición de ras | |
CL2022003360A1 (es) | Benzofurano, benzopirrol, benzotiofeno sustituidos y otros inhibidores del complemento estructuralmente relacionados (divisional de la solicitud 202002578) | |
ECSP055719A (es) | Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos | |
BR112021017350A2 (pt) | Combinação de conjugado de anticorpo-derivado de pirrolobenzodiazepina e inibidor de parp | |
CL2022000875A1 (es) | Inhibidores del factor d del complemento para administración oral | |
UY39150A (es) | Pirrolopirimidinaminas como inhibidores del sistema del complemento | |
CO2019004004A2 (es) | Composición farmacéutica y método para el tratamiento de la enfermedad del hígado graso no alcohólico | |
CO2022005926A2 (es) | Inhibidores del factor d del complemento para administración oral | |
AR127470A1 (es) | Inhibidores de lrrk2 | |
CO2022011258A2 (es) | Pirazolo-pirimidinas sustituidas y usos de las mismas | |
CO2023004420A2 (es) | Compuestos heterocíclicos como inhibidores del bromodominio cbp/ep300 | |
CL2022002531A1 (es) | Moduladores de nlrp3 | |
PH12019502652A1 (en) | 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases | |
MX2022011697A (es) | Inhibidores de ciclofilina y usos de los mismos. | |
AR127243A1 (es) | Compuestos, composiciones farmacéuticas y métodos para el tratamiento, prevención o manejo de trastornos hiperproliferativos | |
ECSP23034732A (es) | Un inhibidor de magl | |
CL2021001944A1 (es) | Derivados de aminoácidos para el tratamiento de enfermedades inflamatorias | |
AR125372A1 (es) | Compuestos, composiciones y métodos para el tratamiento de trastornos | |
CL2021001093A1 (es) | Compuestos, composiciones, y métodos para modular la actividad cdk9 |