MX2022011697A - Inhibidores de ciclofilina y usos de los mismos. - Google Patents

Inhibidores de ciclofilina y usos de los mismos.

Info

Publication number
MX2022011697A
MX2022011697A MX2022011697A MX2022011697A MX2022011697A MX 2022011697 A MX2022011697 A MX 2022011697A MX 2022011697 A MX2022011697 A MX 2022011697A MX 2022011697 A MX2022011697 A MX 2022011697A MX 2022011697 A MX2022011697 A MX 2022011697A
Authority
MX
Mexico
Prior art keywords
cyclophilin inhibitors
cyclophilin
inhibitors
organ
disorders
Prior art date
Application number
MX2022011697A
Other languages
English (en)
Inventor
Ching - Pong Mak
Hans Fliri
Fashu Ma
Michael Peel
Original Assignee
Farsight Medical Tech Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farsight Medical Tech Shanghai Co Ltd filed Critical Farsight Medical Tech Shanghai Co Ltd
Publication of MX2022011697A publication Critical patent/MX2022011697A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Los compuestos definidos por la fórmula 4 se utilizan como inhibidores de ciclofilina para la prevención o tratamiento de enfermedades o trastornos, tal como lesión de órganos o insuficiencia orgánica.
MX2022011697A 2020-03-26 2021-03-25 Inhibidores de ciclofilina y usos de los mismos. MX2022011697A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020081295 2020-03-26
CN2021078391 2021-03-01
PCT/CN2021/083013 WO2021190601A1 (en) 2020-03-26 2021-03-25 Cyclophilin inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX2022011697A true MX2022011697A (es) 2022-10-07

Family

ID=77891510

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022011697A MX2022011697A (es) 2020-03-26 2021-03-25 Inhibidores de ciclofilina y usos de los mismos.

Country Status (12)

Country Link
US (2) US20230174583A1 (es)
EP (2) EP4126904A1 (es)
JP (2) JP2023518777A (es)
KR (2) KR20220158761A (es)
CN (2) CN115335389A (es)
AU (1) AU2021240762A1 (es)
BR (1) BR112022018929A2 (es)
CA (2) CA3172601A1 (es)
IL (1) IL296586A (es)
MX (1) MX2022011697A (es)
TW (1) TW202144379A (es)
WO (2) WO2021190604A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
GB202207348D0 (en) * 2022-05-19 2022-07-06 Cypralis Ltd Macrocyclic compounds and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200703157B (en) * 2004-10-01 2008-08-27 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
CN101511357B (zh) * 2006-05-19 2011-11-02 西尼克斯公司 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用
WO2008143996A1 (en) * 2007-05-18 2008-11-27 Scynexis, Inc. New chemical processes
US9890198B2 (en) * 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
US20140213508A1 (en) * 2012-10-19 2014-07-31 Scynexis, Inc. Antiviral macrocycles
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
CN106902346A (zh) * 2015-12-23 2017-06-30 中美华世通生物医药科技（武汉）有限公司 药物组合物及其制药用途
CN106902347A (zh) * 2015-12-23 2017-06-30 中美华世通生物医药科技（武汉）有限公司 亲环孢素抑制剂的用途
EP3458470A4 (en) * 2016-05-17 2020-04-22 S&T Global Inc. NEW CYCLOSPOR DERIVATIVES AND USES THEREOF
GB201711749D0 (en) * 2017-07-21 2017-09-06 Cypralis Ltd Cyclosporin analogues and uses thereof
WO2020037530A1 (en) * 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine
CN111449050A (zh) * 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途

Also Published As

Publication number Publication date
CN115298199A (zh) 2022-11-04
EP4126905A1 (en) 2023-02-08
AU2021240762A1 (en) 2022-10-06
KR20220158760A (ko) 2022-12-01
TW202144379A (zh) 2021-12-01
IL296586A (en) 2022-11-01
BR112022018929A2 (pt) 2022-12-06
JP2023518776A (ja) 2023-05-08
JP2023518777A (ja) 2023-05-08
US20230174583A1 (en) 2023-06-08
US20230110497A1 (en) 2023-04-13
WO2021190601A1 (en) 2021-09-30
CA3172601A1 (en) 2021-09-30
KR20220158761A (ko) 2022-12-01
CA3172535A1 (en) 2021-09-30
CN115335389A (zh) 2022-11-11
EP4126904A1 (en) 2023-02-08
WO2021190604A1 (en) 2021-09-30

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