CN107090440A - 腺病毒组装方法 - Google Patents

腺病毒组装方法 Download PDF

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CN107090440A
CN107090440A CN201710150508.3A CN201710150508A CN107090440A CN 107090440 A CN107090440 A CN 107090440A CN 201710150508 A CN201710150508 A CN 201710150508A CN 107090440 A CN107090440 A CN 107090440A
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C.奥谢
C.鲍尔斯
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Abstract

本文提供了组装改良腺病毒的方法、腺病毒基因模块文库和它们的组合物。

Description

腺病毒组装方法
本发明是基于申请日为2011年8月16日，申请号为“201180050029.5”(国际申请号为PCT/US2011/048006)，发明名称为“腺病毒组装方法”的专利申请的分案申请。
相关申请的交叉引用
本申请要求2010年8月16日提交的美国临时申请61/374,198的权益，为了所有目的，该临时申请全部并入本文。
发明背景
有52种人类腺病毒感染不同的人组织，还有上百种腺病毒能够感染从鱼到灵长动物的其他物种。这些病毒是高效的纳米级机器，能够在感染1小时内将它们的遗传物质有效负载至细胞核内。这些DNA病毒不整合到宿主DNA中，利用成熟的GMP方案可以产生高滴度的病毒，而且它们在为了表达异常基因进行的研究和人类基因治疗应用中表现很安全。但是，到目前为止，由于使用几乎只限于一个变种Ad5或Ad2/5嵌合体以及不能快速和系统地构建和组合多个基因修饰，它们的潜在应用受到了局限。因此，需要将常用的腺病毒载体扩展到Ad2/5以外，并且要建立一个技术平台来协助由组成部分快速离体地组装新的腺病毒基因组，以便能够系统地引入多个修饰和异源元件。这样的系统可以利用天然的病毒架构在能够高效运送和表达36个基因(不包括剪接变体)方面的优点。所述系统可以提供有力的诊断剂和治疗剂，这些诊断剂和治疗剂包含对不同肿瘤样品中失去调控的途径活性的多重和定量测量。
腺病毒载体在多种应用中的潜力受限于快速和系统地操纵36kb病毒基因组的能力。而且，基础研究、动物模型、基因治疗和溶瘤治疗中使用的腺病毒载体只限于腺病毒(Ad)血清型2和5。Ad2和Ad5居于最早发现的腺病毒之列，因此传统上有大量载体/工具来操纵它们的基因组，特别是E1区域。Ad2/5纤维蛋白(Fiber proteins)通过结合受体CAR感染上皮细胞。不幸的是，不是所有类型的细胞都表达CAR，而且CAR在许多转移病例中被下调。再
我们的最终目的是建立强力的癌症病毒疗法，所述疗法不仅能够进行肿瘤选择性裂解复制，还可以在多轮治疗中进行系统地给药、避免对肝脏的毒性、有效地靶向和穿越令人苦恼的肿瘤血管、经由不同的受体感染细胞、在肿瘤内通过前药活化酶/毒素的局部表达产生肿瘤旁观者效应并且复苏有益的宿主抗病毒免疫反应。这些主要挑战因为人类腺病毒不能在小鼠中复制而更加严重。这排除了相比异种移植模型有许多优势的在免疫活性癌症基因工程小鼠模型(GEMMs)中进行人溶瘤病毒评价的可能。
52种人类腺病毒的存在表明腺病毒高度专性适应不同宿主组织环境中的感染和复制。这些病毒中的许多可以感染不同组织，并且含有能够结合除CAR之外的细胞受体的纤维蛋白以及一群不同的‘E3’免疫调节基因。由于缺少修饰它们的基因组所需要的工具，对它们的这些独特属性还没有广泛的研究或利用。类似地，还存在感染其他物种的腺病毒，包括鼠腺病毒(MAV-1)。
本文提供了对现有技术中的这些和其他问题的解决方案。
发明概述
本发明一方面提供了制备重组腺病毒的方法(文中又称为“Adsembly”)。所述方法包括由两个或更多个腺病毒基因模块组装核酸，所述模块选自E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或者腺病毒大模块(macromodule)(或者如下文描述的突变体)。
本发明另一方面提供了包含复数个腺病毒基因模块的文库。
本发明另一方面提供了实施本文提供的方法的试剂盒。
附图简述
图1.现有腺病毒载体方法和Adsembly的比较列表。Adsembly克服了现有系统中的多个限制。
图2.进一步开发腺病毒作为治疗剂所需要克服的挑战。简图表明了该领域需要克服的几个主要问题。
图3.列举了四种不同腺病毒属的系统发生树。没有列出所有已知腺病毒。该图展示了腺病毒家族中的种类多样性。
图4.52种已知的人腺病毒的受体和向性。受体和向性在血清型和亚型之间有所不同，因此可以利用这一点来重新靶向某些病毒。
图5.腺病毒各属中保守的“核心”基因组区。顶端的图是人Ad5基因组(SEQ ID No:137)的简化图谱，其中的核心区以虚线框强调。正如下端图中围绕基因的白框表明的，该核心区在所有腺病毒属中保守。所有属都含有该核心区，并且几乎全部的核心开放读框都是从IVa2(左端)到pVIII(右端)。基因组的多变性存在于基因组的末端。申请人将我们的模块名称划分为E1模块(文中又称为E1样模块)(条带指示的核心区左侧的全部)、核心模块(条带指示的)和E3模块(文中又称为E3样模块)(条带指示的核心区右侧的全部)，因为模块内容在不同腺病毒种类之间会有所变化，但它们相对核心区的位置不会变。一些情况中，纤维(fiber)紧挨着核心区，而在其他(人Ads)中位于核心区之外。
图6.多种腺病毒属的转录图谱，显示了腺病毒种类之间的保守转录单位。显示了核心基因，以及在一或两个属中可以看到的基因。该图可以看出不同属之间基因组末端的多样性。这里引用的"Davison,Benko,Harrach"是指M et al.,(2005)FamilyAdenoviridae.Fauquet CM,Mayo MA,Maniloff J,Desselberger U,Ball LA(eds):VirusTaxonomy.VIIIth Report of the International Committee on Taxonomy ofViruses.Elsevier,New York pp 213-228。
图7A-7C.SEQ ID NO:32给出的人Ad5聚合酶蛋白中氨基酸966-1103(底端，紧靠共有序列的上方)与来自非人腺病毒的多个聚合酶蛋白中的相应区域的比对。每个非人Ad序列在与该Ad5聚合酶序列进行分别比较时，该区域内至少45％相同。左侧的记号表示GenBank登录号，从上到下分别对应SEQ ID NO:1-32。
图7D-7G.SEQ ID NO:73给出的人Ad5六邻体蛋白(hexon protein)中氨基酸501-747(底端，紧靠共有序列的上方)与来自非人腺病毒的多个六邻体蛋白中的相应区域的比对。每个非人Ad序列在与Ad5六邻体序列进行分别比较时，该区域内至少45％相同。左侧的记号表示GenBank登录号，从上到下分别对应SEQ ID NO:33-73。
图7H-7I.SEQ ID NO:103给出的人Ad5 DNA结合蛋白中氨基酸408-475(底端，紧靠共有序列的上方)与来自非人腺病毒的多个DBPs中的相应区域的比对。每个非人Ad序列在与Ad5 DBP序列进行分别比较时，该区域内至少35％相同。以黄色标识的残基在各物种之间是100％保守的。左侧的记号表示GenBank登录号，从上到下分别对应SEQ ID NO:74-103。
图7J.SEQ ID NO:135给出的人Ad5 pVIII蛋白中氨基酸6-43(底端，紧靠共有序列的上方)与来自非人腺病毒的多个pVIII蛋白中的相应区域的比对。每个非人Ad序列在与Ad5 pVIII序列进行分别比较时，该区域内至少35％相同。左侧的记号表示GenBank登录号，从上到下分别对应SEQ ID NO:104-135。
图8.腺病毒基因组操作的初始概念一览。
图9.利用四个DNA片段进行的多位点gateway的简单示意图。多位点gateway是我们提议的用于重新组装基因组的系统。左侧是提议的系统。
图10A.详细说明gateway att重组位点的命名和组织的示意图。由Gateway克隆得到了四种不同的att重组位点。四种均含有21bp的中央attB区，这里是重组真正发生的位置。利用特异的酶混合物(BP)将attP位点与attB位点重组。得到的反应产生了attL和attR位点。用另一种酶混合物(LR)可以使反应逆向进行，这时attL和attR重组形成attP和attB。
图10B.6个不同att位点之间的序列差别。每个位点特异地与它的配对位点重组。attB1位点只与attP1位点重组，attB2只与attP2，等等。
图11.A)人Ad5基因组(SEQ ID NO:137)分为重组装模块的例子。B)利用多位点gateway技术将提议的模块重新组装后，attB位点的插入位置。
图12.人Ad5基因组(SEQ ID NO:137)中可能的attB插入位点的例子。可以通过将目标区域内的多种腺病毒序列进行比对，选择非保守序列周围的位置来确定插入位点。箭头表示给Ad5选择的位点。A)E1和E2模块之间的attB4插入。B)E2和L3模块之间的attB6插入位点。C)L3和E3模块之间的attB5插入。D)E3和E4模块之间的attB3插入位点。对于该具体插入，我们决定通过提供双份的位于纤维polyA/终止子和E4 polyA之间的Ad5序列给该重组位点提供一个缓冲区。因此，与attB插入一起，在这两个元件之间有27bp的重复。
图13.试图通过PCR获得5个Ad5模块时的挑战和结果。底部的表列出了PCR获得的每个片段的测序结果以及与已经发表的Ad5序列的差别。因为所有错误的再现性都是100％，这说明我们使用的模板与发表的Ad5序列不同，且该PCR的忠实度很高。
图14.Ad5腺病毒基因模块可以通过PCR由直接得自纯化的病毒的DNA获得。从纯化的病毒中直接分离Ad5基因组DNA，作为Ad5模块PCRs的模板。所有5个PCRs都成功。左边小图:一式四份的E2和L3模块PCR。右边小图:一式两份的E1、E3和E4模块PCR。红色箭头指示所需的PCR产物。右侧的箭头省略了，因为目标产物非常清楚。
图15.Ad5腺病毒基因模块在gateway BP反应中的效率。E1、E2和L3模块在标准反应中无效，而E3和E4模块有效。
图16.不依赖序列和连接反应的克隆法(SLIC)的示意图。左侧是单一片段SLIC，而右侧是多(9)片段SLIC的例子。
图17.利用SLIC，在不使用gateway克隆酶的情况下制备gateway入门载体。
图18.Ad5 E1区对细菌有中等毒性。利用SLIC，将Ad5 E1区或对照(lacZ)插入gateway DONR载体。lacZ对照上的所有菌落均是“正常”大小，对lacZ插入是阳性的。E1平板上只出现了两个“正常”大小的菌落，两个菌落对E1都是阴性。但是，有几个较小的菌落(箭头)，全部都是E1阳性的。因此，Ad5 E1区延缓了细菌的生长。这解释了为什么我们无法利用gateway重组反应插入E1。
图19.由5个模块入门载体重新组装Ad5基因组的原始的多位点gateway策略。首先，将5个入门载体中的3个与填充载体合并。然后去除填充载体以便插入反选盒(counterselection cassettes)。然后合并最后的2个入门载体从而形成完整的基因组。该特定策略显示出与E1模块关联的毒性，以及E2和L3模块的大体积。
图20.人Ad5 Adsembly双DEST载体的形成。E2和L3模块由各自的入门载体通过PCR获得，并利用SLIC与载体骨架合并。然后，将载体消化后，通过SLIC将gateway反选盒插到模块旁侧，模块末端带有独特的限制酶位点。
图21.人Ad5的Adsembly过程。将核心模块双DEST载体与其余的3个入门载体中的一个在gateway LR反应中合并从而重新组装完整的病毒基因组。
图22.Adsembly方法中尝试的多个反选标记物的效率。使用了PheS+ccdB，对于通过菌落盲选，或者首先利用菌落PCR鉴定到插入然后通过标准的限制酶消化筛选都是有效的。
图23.Adsembly载体骨架含有适合所述方法的实施方案的两个独特属性。载体骨架使用的是p15A复制原点，降低了质粒的拷贝数，从而减少Ad5 E1模块介导的毒性。此外，载体含有哺乳动物I-SceI表达盒，这使得转染后病毒基因组能够从载体骨架上自剪切下来。
图24.Adsembly反应的效率。A)Ad5的Adsembly反应使用了20fmol核心双DEST载体和各10fmol的E1模块、E3模块和E4模块入门载体进行。反应在室温下过夜进行，第二天转化到NEB10-β细胞中。长出16个克隆，经过处理以备经EcoRV消化进行筛选。16个克隆中的2个显示出正确的限制酶消化样式(星号，克隆4和8)。“L”是DNA序列梯(ladder)。“(-)”是阴性对照，即经过消化的核心双DEST载体。“(+)”是阳性对照，经过消化的完整Ad5基因组。B)提高E1入门载体的量增强了Adsembly的效率。Ad5的Adsembly反应使用了20fmol核心双DEST载体、50fmol E1模块入门载体和各10fmol的E3和E4模块入门载体。反应在室温下过夜进行，第二天转化到NEB10-β细胞中。长出10个克隆，经过处理以备经EcoRV消化进行筛选。10个克隆中的7个显示出正确的限制酶消化样式(红色星号).“L”是DNA序列梯。“(-)”是阴性对照，即经过消化的Ad5 E2-E4载体。“(+)”是阳性对照，即经过消化的完整Ad5基因组。
图25.人Ad5的AdSlicR方法。从给Adsembly制备的E2-L3核心模块开始，载体经SwaI消化被线性化。然后利用SLIC将E3和E4模块插入载体。后续的载体用PacI线性化，然后通过SLIC插入E1模块形成完整基因组。
图26.人Ad5 AdSlicR方法中的效率。菌落PCR作为第一道筛选流程，然后将PCR阳性克隆进行限制酶消化。
图27.Adsembled(经Adsembly制得的)病毒在组织培养中的生长情况。A)通过Adsembly组装的复制型腺病毒形成的噬菌斑。将Adsembled 基因组转染到293细胞中，到第7天出现肉眼可见的噬菌斑。B)Adsembled Ad5的传代和继续生长。从Adsembled Ad5的转染收集总病毒，重新在新鲜的293细胞上铺板。第3天可以看出波及整个平板上的明显致细胞病变效应。
图28.Adsembled Ad5生长在293细胞中时滴度只有略微下降。293细胞用MOI＝10的野生型Ad5、Adsembled Ad5或AdSLIC Ad5(不含有attB插入或者分别含有四种attB插入中的一个)转染。48小时后收集总病毒，经ELISA测定滴度。唯一显示出缺陷的病毒是Adsembled病毒和只含有attB3插入的AdSLIC病毒。与野生型水平相比，均表现出适度的2倍下降。这些数据还显示利用AdSLIC制备的病毒在293细胞中没有复制缺陷。所有病毒的输入水平经过滴定，接近1e7 IU/mL(未显示)。
图29.图29A给出了本文描述的Adsembly入门载体文库中的载体。首先列出了模块所来源的Ad血清型，之后是对载体进行的改变。如果没有变化，标记为“野生型”。图29B给出了用于本文描述的Adsembly和AdSLIC的大模块载体。首先列出了大模块Ad所来源的血清型，之后是包含大模块的模块，然后是对载体进行的任何改变。如果没有变化，标记为“野生型”。图29C给出了利用本文描述的Adsembly或AdSLIC组装成的腺病毒基因组。首先列出了基因组所基于的Ad血清型，之后是对病毒进行的任何改变。如果没有变化，标记为“野生型”。
图30.利用SLIC将完整基因组插入质粒。A)所述过程的示意图，经PCR获得的质粒载体含有与要插入的病毒基因组末端同源的短片段(～20bp)。然后用T4DNA聚合酶处理基因组和载体，正常用于SLIC。B)完整Ad5基因组插入质粒骨架的例子。筛选到的所有6个克隆都含有完整的基因组。因为基因组可以正向或者反向插入，这里的情况中四个处于一个方向(克隆1、4、5和6)，两个处于另一个方向(克隆2和3)。
图31-33描述了腺病毒基因组改造的方法。
图34.上方小图:利用AdSLICr系统，组装非人腺病毒-小鼠腺病毒1型的基因组(SEQ ID NO:104)的例子。E1、E3-纤维蛋白和E4模块质粒的设计使得可以用限制性酶对它们进行切割留下突出端，所述突出端是将它们经过序列和连接不依赖性克隆(SLIC)到线性化(用SwaI或PmeI)核心载体中所需的。这将减少为了获得SLIC所需的线性片段而进行PCR的必要，从而消除引入错误的可能。设计还保证最终的基因组构建体中不插入外来序列。一般方法包括切割E3-纤维蛋白和E4模块，并与PmeI线性化的核心载体合并。这生成了E2-E4大模块，然后用SwaI对其进行切割，并与切割好的E1模块合并产生完整的基因组。下方小图:利用以上策略组装了野生型1型鼠腺病毒，转染小鼠3T6细胞后获得能形成噬菌斑的感染性病毒。
图35.为了鉴定会妨碍生长的插入位点，对含有单一attB重组位点插入的病毒的生长分析。因为利用Adsembly制备的病毒与野生型病毒相比，有略微的生长缺陷(图28)，所以利用AdSLIC制备病毒，这样它们只含有利用Adsembly制备的病毒中带有的attB插入中的一个。293细胞(上方图形)被以MOI＝10感染。U2OS细胞(下方图形)被以MOI＝50感染。48小时后收集总病毒并滴定。模块[L3]和[E3]之间的attB5插入与野生型病毒相比没有影响在U2OS细胞中的生长，但其他三个接点处的attB插入与野生型细胞相比的确对生长有抑制。
图36.因为位于E1和E2-L2模块之间的初始attB4插入位点造成了生长缺陷(图35)，设计了替代的位置选项。碱基对位点参照SEQ ID NO:137中给出的位点。
图37.由于位于E3和E4模块之间的初始attB3插入位点造成了生长缺陷(图35)，设计了替代的位置选项。碱基对位点参照SEQ ID NO:137中给出的位点。
图38.用病毒以MOI＝50感染U2OS细胞，48小时后收集总病毒并滴定。将利用Adsembly生成的三种病毒与野生型病毒进行比较。含有替代attB位点插入的病毒(黑色菱形和三角形)与原来的attB位点安置(黑色X’s)相比，生长情况改善。所有这些病毒缺少位于L2和L3模块之间的attB位点，并且含有不影响生长的位于L3和E3模块之间的attB插入。
图39.Adsembly可以用于生成病毒，所述病毒中从E1模块开始表达转基因。这种情况中，在E1模块中用GFP表达盒替换Ad5的E1A和E1B基因。利用Adsembly组装病毒，得到了表达GFP的活病毒。
图40.Adsembly可以用于生成病毒，所述病毒中利用天然的病毒转录架构从E3模块开始表达转基因。E3模块经过改造被删除了11.6K的蛋白(Ad5核苷酸29491-29772)，代之以mCherry。然后E3转录物自然剪接产生mCherry基因，蛋白得以表达。显示了利用Adsembly进行病毒的制备和U2OS 细胞的转导。这是1)从E3模块开始的转基因表达，和2)利用天然的病毒转录构架表达外来基因的例子。
图41.利用天然的病毒转录架构从E4模块开始表达多重转基因。将天然E4启动子替代为CMV启动子，3个天然E4基因替代为转基因。然后利用Adsembly生成病毒。碱基对位点参照SEQ ID NO:137中给出的位点。
图42.Adsembly可以用于生成病毒，所述病毒中利用天然病毒转录架构从E4模块开始表达多重转基因。用图41中制备的病毒向U2OS细胞中转导24小时，收集总RNA，由RNA通过随机引发合成cDNA，进行PCR来检测对mCherry基因的剪接。黑色箭头指示未剪接的转录物，该转录物会表达GFP。白色箭头指示发生剪接的转录物，该转录物表达mCherry。这显示了由单一模块可以表达多重外来基因。泳道1和2分别是未被转导的细胞或者感染了野生型Ad5的细胞的阴性对照。
图43.利用Adsembly在单个基因组组装中给多重模块引入多种类型的变化。示意图显示了Ad5基因组的5个模块，其中的垂直箭头指示在完整基因组组装前给每个模块做的改变。E1模块被转化为荧光素酶-GFP融合蛋白的转基因表达盒。L3模块中的六邻体蛋白通过点突变将Glu 451改变为Gln。E3模块中天然Ad5纤维的一部分被来自其他的人腺病毒血清型的多种纤维组分之一所替代。利用Adsembly制备了6种病毒，每种含有代替的纤维蛋白。给Ad5列出的碱基对位点参照SEQ ID NO:137中给出的位点。登录号DQ086466、AJ854486、BK001453、NC_001460和AY_737797分别对应SEQ ID NO:139-143。
图44.利用Adsembly生成的纤维嵌合病毒与正常Ad5纤维相比，在人胚胎干细胞(hESC)中的转导能力提高。以不同MOIs将人ESC转导24或48小时，经显微镜测量GFP表达。顶端小图是不含病毒的阴性对照。第二行小图是表达处于CMV启动子调控下的GFP的“Ad5CMV-GFP”。左侧标明了所检验的病毒纤维嵌合体(即Ad5/3是带有Ad3纤维球部的Ad5)。所有图像是在5x放大倍数摄取的。
图45.将腺病毒血清型的核心模块进行交换产生了有活性的病毒。制备了来自Ad11的核心模块。Ad5 E1和E3模块经过改造分别带有Ad11 pIX和U外显子-纤维。利用AdSLIC组装了整个病毒，病毒在293细胞上重建。“最终病毒”列表中提到的碱基对位置与SEQ ID NO:137(Ad5)和SEQ ID NO:141(Ad11)中给出的一致。
图46.利用AdSLIC对病毒基因进行突变以便研究基因在病毒感染方面的功能。在E1模块中，E1B-55K基因中的His 260位点被突变为Ala。其他所有模块是野生型的。该病毒是利用AdSLIC组装的。用复制缺陷型Ad5(泳道1)、野生型Ad5(泳道2)或者Ad5 H260A(泳道3)以MOI＝10感染人小气道上皮细胞。感染后36小时收集总蛋白，通过Western印迹进行p53(顶端小图)、mdm2、Ad5晚期蛋白和肌动蛋白分析。与野生型Ad5不同，Ad5-H260A病毒不能降解p53，在晚期蛋白的产生方面有缺陷。
发明详述
定义
“核酸”是指单链或双链形式的脱氧核糖核苷酸或核糖核苷酸和它们的聚合物，以及它们的互补链。该术语涵盖这样的核酸，所述核酸含有已知的核苷酸类似物或者骨架带有修饰的残基或连接；所述核酸是合成的、天然存在的和非天然存在的；所述核酸与参照核酸有类似的结合性能并且与参照核苷酸的代谢方式类似。这种类似物的例子包括，但不限于硫代磷酸酯、胺基磷酸酯、甲基磷酸酯、手性-甲基磷酸酯、2-O-甲基核糖核苷酸、肽核酸(PNAs)。
除非另有说明，特定核酸序列还暗含其保守性修饰的变体(例如简并密码子取代)和互补序列，以及明确指出的序列。具体来说，可以通过产生这样的序列来实现简并密码子取代，所述序列中的一或多个选中(或全部)密码子的第三个位点被混合碱基和/或脱氧肌苷残基取代(Batzer et al.,Nucleic Acid Res.19:5081(1991)；Ohtsuka et al.,J.Biol.Chem.260:2605-2608(1985)；Rossolini et al.,Mol.Cell.Probes 8:91-98(1994))。术语核酸与基因、cDNA、mRNA、寡核苷酸和多核苷酸可以互换使用。
特定核酸序列还暗含“剪接变体”。类似地，由核酸编码的特定蛋白暗含由该核酸的剪接变体编码的所有蛋白。“剪接变体”正如这个名字暗示的是基因替代剪接的产物。转录结束后，开始的核酸转录物可能发生剪接，使得不同(替代)核酸剪接产物编码不同的多肽。剪接变体的产生机制可能各不相同，但都包括外显子的替代剪接。由同一核酸经过通读转录产生的替代的多肽也涵盖在这个定义中。剪接反应的任何产物，包括重组形式的剪接产物都包括在这个定义中。Leicher,et al.,J.Biol.Chem.273(52):35095-35101(1998)中讨论了一例钾离子通道剪接变体。
构建含有所需治疗基因编码和调控序列的合适载体可以采用常规的连接和限制性酶切技术，这些技术在本领域已有很好的了解(参见Maniatis et al.,in MolecularCloning:A Laboratory Manual,Cold Spring Harbor Laboratory,New York(1982))。可以将分离的质粒、DNA序列或者合成寡核苷酸切割、修饰并按照需要的形式重新连接。
核酸在与另一个核酸序列形成功能性关系时是“可操纵地连接”。例如，编码前体序列或者分泌前导序列的DNA如果能够表达为参与多肽分泌的前体蛋白，则所述DNA是可操纵地连接编码多肽的DNA；启动子或增强子如果能够影响序列的转录，则所述启动子或增强子是可操纵地连接编码序列；或者核糖体结合位点如果定位方式如果能够协助翻译的进行，则所述核糖体结合位点是可操纵地连接编码序列。通常，“可操纵地连接”意味着被连接在一起的DNA序列距离很近，而且对于分泌前导序列的情况，是连续的和符合读框的。但增强子不需要必须连续。连接是通过在方便的限制酶切位点进行相连完成的。如果不存在这样的位点，可以按照常规做法使用合成寡核苷酸适配子或接头。
在提及两个或更多个核酸或多肽序列的语境中，术语“相同的”或“同一性”百分比是指利用BLAST或BLAST 2.0序列比较算法，使用以下描述的缺省参数，或者通过人工比对和目测进行测量(参见例如NCBI网站等)，所述两个或更多个序列或子序列是相同的，或者含有特定百分比的氨基酸残基或核苷酸是相同的(即在比较窗口或者指定区域内按照最大对应性进行比较和对位排列时，特定区域内有大约60％的同一性，优选65％、70％、75％、80％、85％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或更高的同一性)。这样的序列即可被认为是“基本相同的”。这个定义还可以指示或者可以应用于测试序列的互补序列。定义还包括含有缺失和/或添加的序列，以及含有取代的序列。正如以下描述的，优选的算法可以can account for gaps等。优选地，至少大约25个氨基酸或核苷酸长的区域内存在同一性，或者更优选地在50-100个氨基酸或核苷酸的区域内。
为进行序列比较，一般将一个序列作为参照序列，将测试序列与它相比。使用序列比较算法时，将测试和参照序列输入计算机，指定子序列坐标，如果需要还可以指定序列算法的程序参数。优选地，可以使用缺省程序参数，或者可以指定替代参数。然后序列比较算法基于程序参数计算测试序列相对参照序列的序列同一性百分比。
“比较窗口”用于本文包括两个序列被最优化对位排列后，选自多个由20-600，优选大约50-大约200，更通常是大约100-大约150个位点组成的连续位点之一的区段，其中所述序列与具有相同数量连续位点的参照序列进行比较。用于将序列对位排列进行比较的方法是本领域已知的。可以如下实施序列比较的最佳对位排列，例如通过Smith&Waterman,Adv.Appl.Math.2:482(1981)的局部同源性算法；通过Needleman&Wunsch,J.Mol.Biol.48:443(1970)的同源比对算法；通过Pearson&Lipman,Proc.Nat’l.Acad.Sci.USA 85:2444(1988)的寻找相似性的方法；通过这些算法的计算机化实施(Wisconsin GeneticsSoftware Package中的GAP、BESTFIT、FASTA和TFASTA,Genetics Computer Group,575Science Dr.,Madison,WI)；或者通过人工比对和目测(参见例如Current Protocolsin Molecular Biology(Ausubel etal.,eds.1995supplement))。
适用于确定序列同一性百分比和序列相似性的算法的优选例子是BLAST和BLAST2.0算法，这两个算法分别在Altschul et al.,Nuc.Acids Res.25:3389-3402(1977)和Altschul et al.,J.Mol.Biol.215:403-410(1990)中有描述。使用了参数如文中所述的BLAST和BLAST 2.0来确定本发明的核酸和蛋白的序列百分比同一性。正如本领域已知的，进行BLAST分析的软件可以通过National Center for Biotechnology Information公开获得。该算法涉及首先通过鉴定查询序列中长度为W的短字节来鉴定高评分序列对(HSPs)，所述HSPs当与数据库序列中相同长度的字节比对时，或者匹配或者满足某些正数的阈值打分T。T代表相邻字得分阈值(neighborhood word score threshold)(Altschul et al.,同前)。这些初始的匹配相邻字作为种子，启动搜索含有它们的更长的HSPs。将匹配字沿着每个序列，在累加比对得分能够增加的情况下尽量远地向两个方向延伸。对于核苷酸序列，利用参数M(一对匹配残基的奖励分；永远>0)和N(错配残基的罚分；永远<0)计算累加得分。对于氨基酸序列，利用打分矩阵来计算累加得分。当累加比对得分从它达到的最大值下降数量X时；由于一或多个得负分的残基比对的累积，累加得分达到零或以下时；或者到达序列的末端时，停止匹配字在每个方向的延伸。BLAST算法参数W、T和X决定算法的灵敏度和速度。BLASTN程序(用于核苷酸序列)使用的缺省参数为字长(W)＝11、期望值(E)＝10、M＝5、N＝-4，双链比较。对于氨基酸序列，BLASTP程序使用的缺省参数为字长＝3、期望值(E)＝10、BLOSUM62打分矩阵(参见Henikoff&Henikoff,Proc.Natl.Acad.Sci.USA 89:10915(1989))比对(B)＝50、预期值(E)＝10、M＝5、N＝-4，双链比较。
术语“多肽”、“肽”和“蛋白质”在文中可以互换使用来指代氨基酸残基的聚合物。这些术语适用这样的氨基酸聚合物，所述氨基酸聚合物中的一或多个氨基酸残基是相应的天然存在氨基酸的人工化学模拟物；也适用天然存在的氨基酸聚合物和非天然存在的氨基酸聚合物。
术语“氨基酸”是指天然存在的和合成的氨基酸，以及能够按照和天然存在的氨基酸相似的方式发挥作用的氨基酸类似物和氨基酸模拟物。天然存在的氨基酸是由遗传密码编码的那些氨基酸，以及后来发生修饰的氨基酸，例如羟脯氨酸、γ-羧基谷氨酸盐和O-磷酸丝氨酸。氨基酸类似物是指与天然存在的氨基酸有相同的基本化学结构的化合物，即结合在氢原子上的α碳、羧基、氨基和R基团，例如高丝氨酸、正亮氨酸、甲硫氨酸亚砜、甲硫氨酸甲基锍。这些类似物带有被修饰的R基团(例如正亮氨酸)或者被修饰的肽骨架，但保持了和天然存在的氨基酸相同的基本化学结构。氨基酸模拟物是指其结构与氨基酸的一般化学结构不同的化合物，但与天然存在的氨基酸的功能方式类似。
氨基酸在文中可以用它们的众所周知的三字母符号或者IUPAC-IUB BiochemicalNomenclature Commission推荐的单字母符号来表示。类似地，可以用它们的公认单字母代码来指示核苷酸。
“保守性修饰的变体”适用于氨基酸和核酸序列两者。就特定核酸序列而言，保守性修饰的变体是指那些编码相同或基本相同氨基酸序列的核酸，或者对于不编码氨基酸序列的核酸，是指基本相同的序列。由于遗传密码的简并性，有多个功能上相同的核酸编码任何给定蛋白。例如，密码子GCA、GCC、GCG和GCU都编码氨基酸丙氨酸。因此，在密码子限定是丙氨酸的每个位点，可以将密码子改变为上述相应密码子中的任何一个而不会改变被编码的多肽。这样的核酸变异是“沉默变异”，是保守性修饰变体的一种。本文中每个编码多肽的核酸序列还描述了所述核酸的每个可能的沉默变体。本领域技术人员可以认识到核酸中的每个密码子(除了AUG，它通常是唯一的甲硫氨酸的密码子；和TGG，通常是唯一的色氨酸的密码子)都可以被修饰而产生功能相同的分子。相应地，就表达产物而言，每个被描述序列中暗含了多肽编码核酸的每个沉默变体，但对实际的探针序列来说，没有这种含义。
对于氨基酸序列，本领域技术人员可以认识到那些改变、增加或者删除编码序列中的单个氨基酸或较小百分比氨基酸的对核酸、肽、多肽或蛋白序列进行的个别取代、缺失或添加是“保守性修饰变体”，其中所述改变导致氨基酸被化学上相似的氨基酸所取代。给出功能相似氨基酸的保守性取代表格是本领域已知的。这样的保守性修饰变体是本发明的多态性变体、种间同源物和等位基因额外的，而不是排除它们。
以下8个组各自含有相互是保守性取代的氨基酸:1)丙氨酸(A),甘氨酸(G)；2)天冬氨酸(D),谷氨酸(E)；3)天冬酰胺(N)、谷氨酰胺(Q)；4)精氨酸(R)、赖氨酸(K)；5)异亮氨酸(I)、亮氨酸(L)、甲硫氨酸(M)、缬氨酸(V)；6)苯丙氨酸(F)、酪氨酸(Y),色氨酸(W)；7)丝氨酸(S),苏氨酸(T)；和8)半胱氨酸(C)、甲硫氨酸(M)(参见例如Creighton,Proteins(1984))。
提到例如细胞、病毒、核酸、蛋白或载体时使用的术语“重组”表明这些细胞、病毒、核酸、蛋白或载体被引入了异源核酸或蛋白或者天然核酸或蛋白被改变而被修饰，或者细胞来源于被这样修饰的细胞。因此，重组细胞例如表达天然(非重组的)细胞中没有的基因；或者表达的是天然基因，但是表达异常、表达下降或者根本没有表达。
术语“严紧杂交条件”是指这样的条件，在所述条件下探针与通常存在于复杂的核酸混合物中它的靶子序列杂交，但不和其他序列杂交。严紧条件是序列依赖性的，并且随着环境的不同而不同。较长的序列在较高温度下特异杂交。Tijssen,Techniques inBiochemistry and Molecular Biology--Hybridization with Nucleic Probes,“Overview of principles of hybridization and the strategy of nucleic acidassays”(1993)中可以找到关于核酸杂交的全面指南。通常对于限定的离子强度pH，选择的严紧条件比具体序列的融解温度(Tm)低大约5-10℃。Tm是(一定离子强度、pH和核苷浓度下)与靶序列互补的探针有50％与靶序列平衡杂交的温度(靶序列过量的情况下，在Tm，平衡时有50％的探针被占据)。还可能通过加入去稳定剂，比如甲酰胺来达到严紧条件。对于选择性或特异性杂交，阳性信号是背景的至少两倍，优选是背景杂交的10倍。示范性的严紧杂交条件可以如下:50％甲酰胺、5x SSC和1％SDS，42℃温育，或者5x SSC、1％ SDS、于65℃温育，并于65℃在0.2x SSC和0.1％SDS中洗涤。
严紧条件下相互不杂交的核酸如果编码的多肽基本相同，所述核酸仍然是基本相同的。例如核酸拷贝是利用遗传密码所能允许的最大密码子简并性形成的，会发生这种情况。在这种情况中，核酸一般在中等严紧的杂交条件下发生杂交。示范性的“中等严紧杂交条件”包括在37℃下在40％甲酰胺、1M NaCl、1％ SDS的缓冲液中杂交和在45℃在1X SSC中洗涤。阳性杂交至少是背景的两倍。本领域技术人员容易理解可以使用替代的杂交和洗涤条件来提供严紧度相似的条件。确定杂交参数的其他指导方针在许多参考文献和例如Current Protocols in Molecular Biology,ed.Ausubel,et al.,John Wiley&Sons中有提供。
对于PCR，约36℃的温度对于低严紧扩增是典型的，虽然根据引物长度，退火温度可能在约32℃和48℃之间。对于高严紧PCR扩增，约62℃的温度是典型的，虽然根据引物长度和特异性，高严紧退火温度可以处于约50℃到约65℃的范围。对高和低严紧扩增的典型循环条件包括90℃-95℃30秒–2分钟的变性阶段，持续30秒-2分钟的退火阶段，和大约72℃1–2分钟的延伸阶段。Innis et al.(1990)PCR Protocols,A Guide to MethodsandApplications,Academic Press,Inc.N.Y.)中提供了低和高严紧扩增反应的试验方案和指南。
用于本文，术语“癌症”是指在哺乳动物中发现的所有类型的癌症、肿瘤(neoplasm)或恶性肿瘤，包括白血病、癌(carcinomas)和肉瘤(sarcomas)。示范性的癌症包括脑、乳房、宫颈、结肠、头颈、肝、肾、肺、非小细胞肺、黑素瘤、间皮瘤、卵巢、肉瘤、胃、子宫和髓母细胞瘤的癌症。额外的例子包括何杰金氏病、非何杰金氏淋巴瘤、多发性骨髓瘤、神经母细胞瘤、卵巢癌、横纹肌肉瘤、原发性血小板增多症、原发性巨球蛋白血症、原发性脑瘤、癌症、恶性胰岛素瘤、恶性类癌、膀胱癌、恶性前皮肤病损、睾丸癌、淋巴瘤、甲状腺癌、神经母细胞瘤、食道癌、泌尿生殖道癌、恶性高钙血症、子宫内膜癌、肾上腺皮质癌、胰腺内分泌和外分泌的肿瘤以及前列腺癌。
术语“白血病”是泛指造血器官的进展性、恶性疾病，通常特征在于血液和骨髓中白细胞和它们的前体细胞的异常增殖和发育。白血病的临床分类通常基于(1)疾病的持续期和特点-急性或慢性；(2)涉及的细胞类型-骨髓的(髓细胞性)、淋巴的(淋巴性)或者单核细胞型；和(3)血液中异常细胞的增加或未增加-白血病或非白血性(亚白血病性)。P388白血病模型是广泛接受的预测体内抗白血病活性的模型。据信，在P388检测方法中测试显示阳性的化合物一般在体内会表现出一定水平的抗白血病活性，无论被治疗的白血病类型如何。相应地，本发明包括白血病的治疗方法，优选治疗下述白血病的方法：急性骨髓性白血病、慢性淋巴细胞白血病、急性粒细胞性白血病、慢性粒细胞性白血病、急性早幼粒细胞白血病、成人T-细胞白血病、非白血性白血病、白细胞不增多性白血病、嗜碱性白血病、母细胞性白血病、牛白血病、慢性髓细胞性白血病、皮肤白血病、胚胎性白血病、嗜酸粒细胞白血病、葛氏(Gross')白血病、毛细胞白血病、成血细胞性白血病、血胚细胞性白血病、组织细胞性白血病、干细胞性白血病、急性单核细胞性白血病、白血病减少性白血病、淋巴性白血病、淋巴细胞性(lymphoblastic)白血病、淋巴细胞性(lymphocytic)白血病、淋巴球性(lymphogenous)白血病、淋巴样白血病、淋巴肉瘤细胞性白血病、肥大细胞白血病、巨核细胞白血病、小原粒细胞性白血病、单核细胞白血病、髓性(myeloblastic)白血病、髓细胞性(myelocytic)白血病、骨髓粒细胞性白血病、髓单核细胞性白血病、内格利型(Naegeli)白血病、浆细胞白血病、多发性骨髓瘤、浆细胞性白血病、早幼粒细胞性白血病、李德尔氏细胞性(Rieder cell)白血病、希林氏(Schilling's)白血病、干细胞性白血病、亚白血性白血病和未分化细胞白血病。
术语“肉瘤”通常所指的肿瘤是由胚胎结缔组织这样的物质组成的，一般包含包埋在纤维或均相物质中的紧密堆积的细胞。可以组合使用抗肿瘤的巯基结合线粒体氧化剂和抗癌剂来治疗的肉瘤包括软骨肉瘤、纤维肉瘤、淋巴肉瘤、黑素肉瘤、粘液肉瘤、骨肉瘤、艾伯内西氏(Abemethy's)肉瘤、脂肉瘤、脂肪肉瘤、软组织腺泡状肉瘤、成釉细胞肉瘤、葡萄状肉瘤、绿色肉瘤、绒毛膜癌、胚胎性肉瘤、Wilms'瘤、子宫内膜肉瘤、间质肉瘤、尤文氏(Ewing's)肉瘤、筋膜肉瘤、纤维母细胞肉瘤、巨细胞肉瘤、粒细胞肉瘤、何杰金氏肉瘤、特发性多发性色素沉着出血性肉瘤(idiopathic multiple pigmented hemorrhagicsarcoma)、B细胞的免疫母细胞肉瘤、淋巴瘤、T细胞的免疫母细胞肉瘤、詹森(Jensen's)肉瘤、卡波西(Kaposi's)肉瘤、库柏法细胞(Kupffer cell)肉瘤、血管肉瘤、白血病性肉瘤、恶性间叶瘤、骨膜外肉瘤、网状细胞肉瘤、劳氏肉瘤(Rous sarcoma)、浆液囊性肉瘤、外阴滑膜肉瘤和毛细管扩张性肉瘤。
术语“黑素瘤”意味着从皮肤和其他器官的黑色素细胞系统发生的肿瘤。可以组合使用抗肿瘤的巯基结合线粒体氧化剂和抗癌剂来治疗的黑素瘤包括例如，肢端雀斑样痣黑素瘤、无黑素性黑素瘤、良性幼年黑素瘤、克罗德曼(Cloudman's)黑素瘤、S91黑素瘤、哈帕二氏(Harding-Passey)黑素瘤、青少年性黑素瘤、雀斑样痣恶性黑素瘤、恶性黑素瘤、结节性黑素瘤、甲床黑素瘤和浅表扩散性黑素瘤。
术语“癌(carcinoma)”是指由上皮细胞构成的恶性新生长物，易于渗透到周围组织，产生转移物。可以组合使用抗肿瘤的巯基结合线粒体氧化剂和抗癌剂来治疗的示范性癌包括例如腺泡癌、腺泡状癌、腺囊性癌、腺样囊性癌、腺癌、肾上腺皮质癌、肺泡上皮癌、肺泡细胞癌、基底细胞癌(basal cell carcinoma)、基底细胞癌(carcinomabasocellulare)、类基底细胞癌、基底鳞状细胞癌、细支气管肺泡癌、细支气管癌、支气管癌、髓样癌、胆管癌、绒膜上皮癌、胶样癌(colloid carcinoma)、粉刺癌、子宫体癌、筛状癌、铠甲状癌、癌疮、柱状细胞癌(cylindrical carcinoma)、柱状细胞癌(cylindrical cellcarcinoma)、导管癌、硬癌(carcinoma durum)、胚胎癌、脑样癌、表皮样癌、腺样上皮细胞癌、外生性癌、溃疡性癌、纤维癌、胶样癌(gelatiniforni carcinoma)、胶状癌(gelatinouscarcinoma)、巨大细胞癌、巨细胞癌、腺癌、粒层细胞癌、基底细胞癌(hair-matrixcarcinoma)、多血癌、肝细胞癌、许特耳氏细胞(Hurthle cell)癌、胶样癌(hyalinecarcinoma)、hypemephroid carcinoma、幼稚型胚胎性癌、原位癌(carcinoma in situ)、表皮内癌、上皮内癌、克龙派切尔(Krompecher's)癌、库尔契茨基细胞(Kulchitzky-cell)癌、大细胞癌、豆状癌(lenticular carcinoma、carcinoma lenticulare)、脂瘤样癌、淋巴上皮性癌、软癌(carcinoma medullare)、髓样癌(medullary carcinoma)、黑色素癌、髓样癌(carcinoma molle)、粘液癌(mucinous carcinoma、carcinoma muciparum)、粘液细胞癌、粘液表皮样癌、粘液癌(carcinoma mucosum、mucous carcinoma)、粘液瘤样癌、鼻咽癌、燕麦细胞癌、骨化性癌(carcinoma ossificans、osteoid carcinoma)、乳头状癌、门脉周癌、原位癌(preinvasive carcinoma)、棘细胞癌、脑样癌、肾脏的肾细胞癌、储备细胞癌、肉瘤样癌、施奈德氏(Schneiderian)癌、硬癌(scirrhous carcinoma)、阴囊癌、印戒细胞癌、单纯癌、小细胞癌、马铃薯状癌、球状细胞癌、梭细胞癌、髓样癌(carcinoma spongiosum)、鳞状癌、鳞状细胞癌、绳捆癌(string carcinoma)、血管扩张性癌(carcinomatelangiectaticum、carcinoma telangiectodes)、移行细胞癌、结节性皮癌(carcinomatuberosum、tuberous carcinoma)、疣状癌和绒毛状癌。
“治疗有效剂量或量”在本文意味着一个能够产生它的给药效应的剂量。确切的剂量和剂型取决于治疗目的，由本领域技术人员利用已知技术确定(参见例如Lieberman,Pharmaceutical Dosage Forms(vols.1-3,1992)；Lloyd,The Art,Science andTechnology of Pharmaceutical Compounding(1999)；Remington:The Science andPractice of Pharmacy,20th Edition,Gennaro,Editor(2003)和Pickar,DosageCalculations(1999))。
术语“可药用盐”或“可药用载体”意味着包括活性化合物的盐，根据本文描述的化合物带有的取代基，所述盐是用相对无毒的酸或碱制备的。本发明的化合物含有相对酸性的功能团时，可以通过在无溶剂或合适的惰性溶剂中用足够量的所需碱与所述化合物的中性形式进行接触获得碱加成盐。可药用碱加成盐的例子包括钠、钾、钙、铝、有机胺或镁盐或者类似的盐。当本发明的化合物含有相对碱性的功能团时，可以通过在无溶剂或合适的惰性溶剂中用足够量的所需酸与所述化合物的中性形式进行接触获得酸加成盐。可药用酸加成盐的例子包括那些由下述无机酸衍生的盐：盐酸、氢溴酸、硝酸、碳酸、重碳酸、磷酸、一氢磷酸、二氢磷酸、硫酸、一氢硫酸、氢碘酸或亚磷酸等等，以及由下述相对无毒的有机酸衍生的盐：乙酸、丙酸、异丁酸、马来酸、丙二酸、苯甲酸、琥珀酸、辛二酸、延胡索酸、乳酸、扁桃酸(mandelic)、邻苯二甲酸、苯磺酸、对甲苯磺酸、柠檬酸、酒石酸、甲磺酸等等。还包括诸如精氨酸等的氨基酸的盐，和诸如葡糖醛酸或半乳糖醛酸的有机酸的盐(参见例如Berge etal.,Journal of Pharmaceutical Science 66:1-19(1977))。本发明的某些特定化合物既含有碱性功能团也含有酸性功能团，使得化合物能够转化为碱或者酸加成盐。本领域技术人员已知的其他可药用载体也适用于本发明。
本发明涉及：
1.制备重组腺病毒的方法，所述方法包括由选自E1模块、E2-L2模块、L3-L4模块、E3模块、和E4模块的三个或更多个腺病毒基因模块组装核酸。
2.如项1所述的方法，其中所述核酸包含E1模块。
3.如项2所述的方法，其中所述核酸还包含E4模块。
4.如项2所述的方法，其中所述核酸还包含E2-L2模块、L3-L4模块，或者既有E2-L2模块也有L3-L4模块。
5.如项1所述的方法，其中在组装所述核酸之前，通过将三个或更多个腺病毒基因模块中的两个组合而形成大模块。
6.如项5所述的方法，其中大模块是E2-L4大模块。
7.如项6所述的方法，其中该方法包括由所述E2-L4大模块和选自E1模块、E3模块、或E4模块的一或多个腺病毒基因模块组装所述核酸。
8.如项1所述的方法，其中该方法包括由选自E1模块、E2-L2模块、L3-L4模块、E3模块、和E4模块的至少四个腺病毒基因模块组装所述核酸。
9.如项8所述的方法，该方法包括由E1模块、E2-L2模块、L3-L4模块、E3模块、和E4模块组装所述核酸。
10.如项8所述的方法，其中所述核酸至少12kb。
11.如项1所述的方法，其中所述核酸包含缺失的腺病毒核酸序列、突变的腺病毒核酸序列、异常腺病毒核酸序列或者编码非腺病毒基因产物的核酸序列。
12.如项11所述的方法，其中所述突变的腺病毒核酸序列编码突变的E4-ORF3基因产物。
13.如项11所述的方法，其中所述突变的腺病毒核酸序列编码突变的E1B-55k基因产物。
14.如项11所述的方法，其中所述突变的腺病毒核酸序列编码突变的腺病毒纤维蛋白基因产物。
15.如项11所述的方法，其中所述突变的腺病毒核酸序列编码突变的病毒外壳蛋白。
16.如项11所述的方法，其中所述异常腺病毒核酸序列编码前药转化酶。
17.如项11所述的方法，其中所述非腺病毒基因产物是报告蛋白。
18.如项11所述的方法，其中所述非腺病毒基因产物是靶向蛋白。
19.如项18所述的方法，其中所述靶向蛋白是肿瘤靶向蛋白或者脉管系统靶向蛋白。
20.如项1所述的方法，还包括转录所述核酸，从而形成重组腺病毒。
21.如项20所述的方法，其中所述重组腺病毒是可复制型的。
22.如项20所述的方法，其中所述重组腺病毒是复制缺陷型的。
23.如项1所述的方法，其中所述方法是在体外实施的。
24.如项1所述的方法，其中所述组装包括将可杂交型目标载体与一或多个可杂交型腺病毒基因模块杂交，从而形成腺病毒基因模块载体。
25.如项24所述的方法，其中所述可杂交型目标载体的形成是通过:
(i)切割目标载体从而形成线性目标载体,和
(ii)将所述线性目标载体与外切核酸酶进行接触从而形成可杂交型的目标载体。
26.如项24所述的方法，其中所述一或多个可杂交型腺病毒基因模块的形成是通过:
(i)将包含一或多个入门载体腺病毒基因模块的入门载体与外切核酸酶进行接触，从而形成一或多个释放出的入门载体腺病毒基因模块，和
(ii)将一或多个释放的入门载体腺病毒基因模块与外切核酸酶进行接触，从而形成一或多个可杂交型腺病毒基因模块。
27.如项1所述的方法，其中组装包括将可重组型的目标载体和一或多个含有一或多个所述腺病毒基因模块的可重组型入门载体与整合酶进行接触，从而形成腺病毒基因模块载体。
28.如项27所述的方法，其中含有一或多个所述腺病毒基因模块的所述可重组型入门载体的形成，是通过将一或多个可重组型腺病毒基因模块和可重组型供体载体与整合酶进行接触，从而形成含有一或多个所述腺病毒基因模块的所述可重组型入门载体。
29.如项1所述的方法，其中组装包括:
(i)将可杂交型目标载体与可杂交型第一腺病毒基因模块杂交，从而形成第一腺病毒基因模块载体；和
(ii)将所述第一腺病毒基因模块载体和可重组型第二腺病毒基因模块入门载体与整合酶进行接触，从而形成第二腺病毒基因模块载体。
30.如项29所述的方法，其中所述第一腺病毒基因模块是E2-L2模块、L3-L4模块、或E2-L4大模块；第二腺病毒基因模块是E1模块、E3模块或E4模块。
31.文库，所述文库包含复数个不同E1模块、复数个不同E2-L2模块、复数个不同L3-L4模块、复数个不同E3模块、复数个不同E4模块或者复数个不同E2-L4大模块。
32.如项31所述的文库，其中所述复数个不同E1模块、所述复数个不同E2-L2模块、所述复数个不同L3-L4模块、所述复数个不同E3模块、所述复数个不同E4模块、或所述复数个不同E2-L4大模块包含来自复数个腺病毒种的腺病毒基因模块。
33.如项32所述的文库，其中所述复数个不同E1模块、所述复数个不同E2-L2模块、所述复数个不同L3-L4模块、所述复数个不同E3模块、所述复数个不同E4模块或所述复数个不同E2-L4大模块包含来自一个以上人腺病毒血清型的腺病毒基因模块。
34.如项31所述的文库，其中所述复数个不同E1模块、所述复数个不同E2-L2模块、所述复数个不同L3-L4模块、所述复数个不同E3模块、所述复数个不同E4模块或所述复数个不同E2-L4大模块包含缺失的腺病毒核酸序列、取代的腺病毒核酸序列、异常腺病毒核酸序列、或者编码非腺病毒基因产物的核酸序列。
35.如项31所述的文库，其中所述复数个不同E1模块、所述复数个不同E2-L2模块、所述复数个不同L3-L4模块、所述复数个不同E3模块、所述复数个不同E4模块或所述复数个不同E2-L4大模块是可重组型的。
36.如项31所述的文库，其中所述复数个不同E1模块、所述复数个不同E2-L2模块、所述复数个不同L3-L4模块、所述复数个不同E3模块、所述复数个不同E4模块或所述复数个不同E2-L4大模块是可杂交型的。
37.根据项1-20中任一项所述方法制备的腺病毒基因组文库。
实施方案详述
I.组装方法
发明一个方面提供了制备重组腺病毒的方法(文中又称为“Adsembly”)。所述方法包括从选自E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或腺病毒大模块(或者象下文描述的它们的突变体)中的两个或者更多个腺病毒基因模块组装核酸。在一些实施方案中，方法包括从选自E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或腺病毒大模块中的三个、四个或五个腺病毒基因模块组装核酸。核酸可以是腺病毒基因组构建体。腺病毒基因组构建体是被表达时(例如被引入哺乳动物细胞中时)能够形成重组腺病毒的核酸。核酸还可以是部分腺病毒基因组构建体，当被表达时(例如被引入哺乳动物细胞中时)，能够与其他病毒(例如辅助病毒)一起形成重组腺病毒。这样形成的腺病毒可以复制并包装产生子代病毒。因此，本文提供的方法可能包括由两个或更多个基因组模块或者异源元件体外组装腺病毒基因组，所述腺病毒基因组在单独(转染感受态细胞系)或者与辅助病毒一起转染到哺乳动物细胞内时能够复制并包装产生子代病毒。基因组模块的选择可以基于进化上保守的序列、转录或者功能元件。在一些实施方案中，方法包括由选自E1模块、E2-L2模块、L3-L4模块、E3模块和E4模块的三个或更多个腺病毒基因模块组装核酸。这样得到的核酸(文中又称为“组装的核酸”)可以在组装后被表达(例如发生复制、转录、翻译和包装)，从而形成重组腺病毒。核酸的表达可以在体外、原位、细胞内(例如通过将核酸转染到细胞内)或者体内进行。在某些实施方案中，表达在细胞内进行从而导致产生细胞。
术语“腺病毒基因模块”用于本文是指E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或者它们的大模块。因此腺病毒基因模块是核酸(例如DNA)。“个别腺病毒基因模块”用于本文是指E1模块、E2-L2模块、L3-L4模块、E3模块或者E4模块。在一些实施方案中，可以在组装核酸之前由更小的子模块组装一或多个个别腺病毒基因模块。腺病毒大模块是E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块中的两个、三个或四个的组合。因此大模块是包含E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块中的两个、三个或四个的线性核酸链(例如DNA)。术语“腺病毒大模块”用于本文是指:
E1-L2大模块(即包含合并的E1模块和E2-L2模块的核酸)；
E1-L4大模块(即包含合并的E1模块、E2-L2模块和L3-L4模块的核酸)；
E1-E3大模块(即包含合并的E1模块、E2-L2模块、L3-L4模块和E3模块的核酸)；
E2-L4大模块(即包含E2-L2模块和L3-L4模块的核酸，文中又称为“核心大模块”)；
E2-E3大模块(即包含合并的E2-L2模块、L3-L4模块和E3模块的核酸)；
E2-E4大模块(即包含合并的E2-L2模块、L3-L4模块、E3模块和E4模块的核酸)；
L3-E3大模块(即包含合并的L3-L4模块和E3模块的核酸)；
L3-E4大模块(即包含合并的L3-L4模块、E3模块和E4模块的核酸)；和
E3-E4大模块(即，包含合并的E3模块和E4模块的核酸)。
在一些实施方案中，腺病毒大模块是E2-L4大模块(即核心大模块)或者E3-E4大模块。当腺病毒大模块被作为两个或更多个选中的腺病毒模块中的一个来组装核酸时，其他选中的腺病毒模块不是所述腺病毒大模块中的个别腺病毒基因模块。换句话说，每个个别腺病毒基因模块在组装成的核酸中无论是单独或者位于大模块内，均只出现一次。例如，当两个或更多个选中组装核酸的腺病毒基因模块中的一个是核心大模块时，不会选择E2-L2或L3-L4模块作为组装好的核酸中包含的另一个模块。同样地，对于选择了三个或更多个腺病毒基因模块的情况，腺病毒大模块不是E1-E3大模块或E2-E4大模块。
在一些实施方案中，方法包括由选自(i)E1模块,(ii)核心大模块和(iii)E3模块、E4模块或E3-E4大模块中的三个腺病毒基因模块组装核酸。方法还可以包括由选自E1模块、核心大模块、E3模块和E4模块的四个腺病毒基因模块组装核酸。
在一些实施方案中，可以在组装核酸之前将一或多个腺病毒基因模块组合形成大模块。对于形成大模块的情况，方法包括由大模块和所述模块中不包含的一或多个个别腺病毒基因模块(即E1模块、E2-L2模块、L3-L4模块、E3模块和/或E4模块)组装核酸。在一些实施方案中，大模块是核心大模块。因此，在一些实施方案中，方法包括利用核心大模块和选自E1模块、E3模块或E4模块的一或多个腺病毒基因模块组装核酸。
腺病毒是一种在细胞核内进行复制的无包膜二十面体病毒。本文提供的腺病毒基因模块是指腺病毒基因组中的某些位点，象例如Davison et al., Journal of GeneralVirology,(2003),84,28695-2938中描述的。在一些实施方案中，腺病毒基因模块来源于人腺病毒。图5是人Ad5的简图，显示了本文提供的腺病毒基因模块和它们的以kb计量的大概大小。每个模块可能编码多重基因产物和替代的基因剪接排列。
“E1模块”用于本文是含有腺病毒反向末端重复(ITR)的核酸。E1模块可能另外包含与组装成的核酸的蛋白编码区可操纵连接的启动子。E1模块一般来源于腺病毒E1A和/或E1B区域。除了ITR区域，E1模块可以还含有从腺病毒基因组的E1末端到病毒聚合酶编码区的任何病毒基因(在下文中有讨论)。例如，E1模块可以另外包含下述的编码区：主要转录激活蛋白E1A(例如编码pRB家族的失活蛋白)、E1B-19K(例如编码细胞凋亡阻断剂)、E1B 55K(例如p53结合、mre结合和病毒mRNA输出蛋白)和/或pIX(例如编码次要结构蛋白和与病毒衣壳上的六邻体相互作用的蛋白)。E1模块可能长大约4kb、3kb、2kb或1kb。在一些实施方案中，E1模块与自然界中发现的腺病毒的E1A和E1B区的长度大概相同(例如参见图5)。
“E2-L2”模块用于本文是含有病毒DNA聚合酶编码区和六邻体蛋白编码区中至少一个的核酸。在一些实施方案中，E2-L2模块还包含病毒DNA结合蛋白编码区。E2-L2模块一般来源于腺病毒E2B的L1和/或L2区。E2-L2模块可能另外包含下述的编码区：E2B IVa2(例如编码晚期转录激活蛋白和协助病毒DNA包装到病毒衣壳中的蛋白)、E2B Pol(例如编码病毒DNA聚合酶)、E2B pTP(例如编码附着在病毒基因组末端，是病毒复制或包装必需的末端蛋白)、L1 52K(例如编码病毒DNA包装到衣壳内所必需的蛋白)、L1IIIa(例如编码帮助稳定衣壳的次要结构蛋白)、L2III(五邻体(penton))(例如编码形成纤维突起处的衣壳顶点的主要结构蛋白)、L2pVII(例如编码与组蛋白H3有同源性并且与衣壳中的病毒DNA连接的核心结构蛋白)、L2V(例如编码在DNA和病毒衣壳之间形成连接的核心结构蛋白)和L2pX(例如编码结合并凝聚病毒基因组的核心结构蛋白)。在一些实施方案中，E2-L2模块与自然界中发现的腺病毒的E2B、L1和L2区的长度大概相同(例如参见图5)。
“L3-L4”模块用于本文是含有病毒DNA聚合酶编码区和六邻体蛋白编码区中的至少一个的核酸。在一些实施方案中，L3-L4模块可能还包含病毒DNA结合蛋白编码区。在一些实施方案中，当E2-L2模块含有病毒DNA 聚合酶编码区时，L3-L4不含有病毒DNA编码区，反之亦然。同样，当E2-L2模块含有六邻体蛋白编码区时，L3-L4不含有六邻体蛋白编码区，反之亦然。同样，当E2-L2模块含有病毒DNA结合蛋白编码区时，L3-L4不含有病毒DNA-结合蛋白编码区，反之亦然。换句话说，病毒DNA聚合酶编码区、六邻体蛋白编码区和病毒DNA结合蛋白编码区一般在组装好的核酸中只出现一次。L3-L4模块还可能包含下述的编码区：L3pVI(例如编码在衣壳和病毒基因组DNA之间于顶点形成连接的次要结构蛋白)、L3II(六邻体)(例如编码形成衣壳三角形面的主要结构蛋白)、L3 23K(例如编码对病毒蛋白进行加工从而完成衣壳组装的病毒蛋白酶)、E2A DBP(例如，编码与病毒DNA结合并协助复制的DNA结合蛋白)、L4 100K(例如编码抑制细胞蛋白的合成并促进病毒晚期蛋白翻译的蛋白)、L433K(例如编码促进晚期病毒基因的剪接的蛋白)、一或多个纤维蛋白和L4 22K(例如编码促进晚期病毒基因表达并协助病毒DNA包装的蛋白)。在一些实施方案中，L3-L4模块与自然界中发现的腺病毒的L3、E2A和L4区的长度大概相同，或者与自然界中发现的腺病毒的L3、E2A、L4和L5区的长度大概相同(例如参见图5)。
“核心大模块”(文中又称为“E2-L4大模块”)用于本文是指含有病毒DNA聚合酶编码区和六邻体蛋白编码区中的至少一个的核酸。在一些实施方案中，核心大模块还包含病毒DNA结合蛋白编码区。在一些实施方案中，核心大模块包含大多数病毒结构蛋白以及DNA复制和包装所需要的蛋白。在一些实施方案中，模块包含病毒DNA聚合酶编码区、六邻体蛋白编码区和病毒DNA聚合酶编码区。在其他实施方案中，核心可能还包含下述的编码区：L3pVI(例如编码在衣壳和病毒基因组DNA之间于顶点形成连接的次要结构蛋白)、L3II(六邻体)(例如编码形成衣壳三角面的主要结构蛋白)、L3 23K(例如编码对病毒蛋白进行加工从而完成衣壳组装的病毒蛋白酶)、E2A DBP(例如编码与病毒DNA结合并协助复制的DNA结合蛋白)、L4 100K(例如编码抑制细胞蛋白的合成并促进病毒晚期蛋白翻译的蛋白)、L433K(例如编码促进晚期病毒基因的剪接的蛋白)、和L4 22K(例如编码促进晚期病毒基因表达并协助病毒DNA包装的蛋白)、E2B IVa2(例如编码晚期转录激活蛋白和协助病毒DNA包装到病毒衣壳中的蛋白)、E2B Pol(例如编码病毒DNA聚合酶)、E2B pTP(例如编码附着在病毒基因组末端，是病毒复制或包装所必需的末端蛋白)、L1 52K(例如编码将病毒DNA包装到衣壳内所必需的蛋白)、L1 IIIa(例如编码帮助稳定衣壳的次要结构蛋白)、L2 III(五邻体)(例如编码形成纤维突起处的衣壳顶点的主要结构蛋白)、L2 pVII(例如编码衣壳中与组蛋白H3有同源性并且与病毒DNA连接的核心结构蛋白)、L2 V(例如编码在DNA和病毒衣壳之间形成连接的核心结构蛋白)、一或多个纤维蛋白以及L2 pX(例如编码结合并凝聚病毒基因组的核心结构蛋白)。在一些实施方案中，L3-L4模块与自然界中发现的腺病毒的E2B、L1、L2、L3、E2A和L4区的长度大概相同，或者与自然界中发现的腺病毒的E2B、L1、L2、L3、E2A、L4和L5区的长度大概相同(例如参见图5)。
病毒DNA聚合酶基因所编码的蛋白含有的序列与SEQ ID NO:32(图7A-C)中给出的人Ad5DNA聚合酶或者来源于另外一个物种的同源物的氨基酸996-1103中至少50个连续(或者全部)氨基酸有至少45％(例如50％、60％、70％、80％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％)的同一性。六邻体基因所编码的蛋白含有的序列与SEQ ID NO:73(图7D-G)中给出的人Ad5六邻体或者来源于另外一个物种的同源物的氨基酸501-747中至少50个连续(或者全部)氨基酸有至少45％(例如50％、60％、70％、80％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％)的同一性。病毒DNA结合蛋白基因所编码的蛋白含有的序列与SEQ ID NO:103(图7H-I)中给出的人Ad5 DNA结合蛋白或者来源于另外一个物种的同源物的氨基酸408-475中至少50个连续(或者全部)氨基酸有至少35％(例如45％、50％、60％、70％、80％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％)的同一性。
“E4模块”用于本文是含有腺病毒反向末端重复(ITR)的核酸。在一些实施方案中，E4另外包含一或多个纤维蛋白的编码区。E4模块可能还包含下述的编码区：E4 orf 6/7(例如编码介导病毒转录的E2F转录激活的蛋白)、E4 orf 6(例如编码促进病毒DNA的合成、稳定和输出病毒晚期mRNAs，以及促进剪接的蛋白)、E4 orf4(例如编码调节病毒转录和剪接并且调制PP2A的蛋白)、E4 orf3(例如编码阻断p53介导的转录、破坏MRN DNA修复复合体和防止环化的蛋白)、E4 orf2和E4 orf1(例如编码促进经由PI3激酶进行的信号传导，从而导致蛋白合成和细胞存活的蛋白)。在一些实施方案中，E4模块与自然界中发现的腺病毒的E4区的长度大概相同，或者与自然界中发现的腺病毒的E4和L5区的长度大概相同(例如参见图5)。
“E3模块”用于本文是含有一或多个纤维蛋白编码区和/或腺病毒反向末端重复(ITR)的核酸。在一些实施方案中，E3模块包含从pVIII的蛋白编码区末端到位于基因组右端的ITR的任何已知腺病毒序列(如图5所示)。pVIII编码区是任何这样的基因，所述基因编码的蛋白含有的序列与SEQ ID:135中给出的人Ad5 pVIII中氨基酸6-43(图7J)中的至少50个连续(或者全部)氨基酸有至少35％(例如50％、60％、70％、80％、90％、91％、92％、93％、94％、95％、96％、97％、98％、99％或100％)的同一性。E3模块可能另外包含下述的编码区：L4 pVIII(例如编码次要结构蛋白)E3 12.5K、E3 CR1α(例如编码阻断细胞凋亡的蛋白)、E3gp19K(例如编码抑制MHC-I抗原呈递的免疫调节蛋白)、E3 ADP(例如编码具有有效裂解细胞以释放病毒的功能的蛋白)、E3 RIDα(例如编码去除细胞表面的促凋亡FasL和TRAIL的免疫调节蛋白)、E3 RIDβ-(例如编码去除细胞表面的促凋亡FasL和TRAIL的免疫调节蛋白)、E3 14.7K(例如编码阻断细胞凋亡的蛋白)和L5IV(Fiber)(例如，编码从五邻体基座伸出的负责受体结合的主要结构蛋白)。在一些实施方案中，E3模块与自然界中发现的腺病毒的E3区的长度大概相同，或者与自然界中发现的腺病毒的E3和L5区的长度大概相同(例如参见图5)。
“E3-E4大模块”用于本文是包含腺病毒反向末端重复(ITR)的核酸。E-3-E4大模块可能还包含从pVIII的蛋白编码区末端到位于基因组右端的ITR的任何已知腺病毒序列(如图5所示)。E3-E4大模块可能另外包含下述的编码区：E4 orf 6/7(例如编码介导病毒转录的E2F转录激活的蛋白)、E4 orf 6(例如编码促进病毒DNA的合成、稳定和输出病毒晚期mRNAs以及促进剪接的蛋白)、E4 orf4(例如编码调节病毒转录和剪接并且调制PP2A的蛋白)、E4 orf3(例如编码阻断p53介导的转录、破坏MRN DNA修复复合体和防止环化的蛋白)、E4 orf2、E4 orf1(例如编码促进经由PI3激酶进行的信号传导，从而导致蛋白合成和细胞存活的蛋白)、L4 pVIII(例如编码次要结构蛋白)、E3 12.5K、E3 CR1α(例如编码阻断细胞凋亡的蛋白)、E3 gp19K(例如编码抑制MHC-I抗原呈递的免疫调节蛋白)、E3 ADP(例如编码具有有效裂解细胞以释放病毒的功能的蛋白)、E3 RIDα(例如编码去除细胞表面的促凋亡FasL和TRAIL的免疫调节蛋白)、E3 RIDβ-(例如编码去除细胞表面的促凋亡FasL和TRAIL的免疫调节蛋白)、E3 14.7K(例如编码阻断细胞凋亡的蛋白)和L5IV(Fiber)(例如，编码从五邻体基座伸出的负责受体结合的主要结构蛋白)。
在一些实施方案中，一或多个腺病毒基因模块相对腺病毒基因模块所来源的天然腺病毒中发现的模块序列(例如野生型)，包含一或多个突变(例如，核酸的取代、添加或缺失)。例如，本文提供的核酸可能编码有效数量的腺病毒基因模块，从而在某些细胞条件下，核酸转染到细胞中时导致形成有复制能力的腺病毒。一或多个腺病毒基因模块中的突变可能使得得到的腺病毒在一些细胞(例如，患病细胞，比如癌细胞)中能够复制，而在其他细胞(例如，未患病细胞，比如健康细胞)中不复制。突变还可能包含一或多个蛋白编码区的添加(例如添加一或多个外源或异源蛋白编码区，比如非病毒蛋白编码区)。一或多个蛋白的添加可能带来额外的病毒功能、丢失病毒功能(例如复制)、提供病毒检测方法(例如荧光标记物)、提供病毒纯化方法(例如带有His标签的衣壳蛋白)或者提供能够产生目标蛋白的病毒，所述蛋白随后经分离和/或纯化进一步使用。因此，突变可能增加了病毒功能或者减少了病毒功能。因此本文制备的重组腺病毒包括通过引入外源(例如异源)核酸或者改变天然核酸序列而被改造的腺病毒。所述改变可以是如上所述通过一或多个腺病毒基因模块中的突变进行的，或者是通过将天然腺病毒基因组中存在的一或多个腺病毒基因模块排除进行的。
因此在一些实施方案中，核酸包括发生突变的腺病毒核酸序列。腺病毒核酸序列是在自然界或者天然腺病毒(例如野生型)中发现的序列。发生突变的腺病毒核酸序列可能是如上所述由一或多个腺病毒基因模块中的突变造成的，或者是通过将天然腺病毒基因组中的一或多个腺病毒基因模块排除得到的。在某些实施方案中，核酸包括发生缺失的腺病毒核酸序列、异常腺病毒核酸序列或者外源(例如异源)核酸序列(例如编码非腺病毒基因产物)。发生突变的腺病毒核酸序列可能包括突变的E4-ORF3基因产物(带来改变的功能)、突变的E1B-55k基因产物、突变的腺病毒纤维基因产物、突变的病毒外壳蛋白、前药转化酶、报告蛋白、突变的六邻体蛋白、与pIX融合的蛋白、对某些细胞有毒性的蛋白、来自获得核酸的类型以外的腺病毒的完整或部分纤维基因、和/或靶向蛋白(例如肿瘤靶向蛋白或者脉管靶向蛋白)。
在一些实施方案中，核酸包含E1模块。核酸还可以包含E1模块和E4模块。在某些实施方案中，核酸包含E1模块和E2-L2模块。核酸还可以包含E1模块和L3-L4模块。核酸还可以包含E1模块、E2-L2模块和L3-L4模块。
在一些实施方案中，方法包括由选自E1模块、核心模块、E3模块和/或它们的衍生物或组分的至少三个腺病毒基因模块组装核酸。在相关实施方案中，例如对于人Ad5，方法包括由E1模块、E2-L2模块、L3-L4模块、E3模块和E4模块组装核酸。在某些实施方案中，形成的核酸至少长10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49或50kb。在一些实施方案中，形成的核酸至少长10、11、12、13、14、15、16、17、18、19、20、21、22kb。在一些实施方案中，形成的核酸至少长10、11、12、13、14、15kb。在一些实施方案中，形成的核酸至少长10、11、12kb。在一些实施方案中，形成的核酸至少长12kb。
由本文提供的方法形成的核酸可以是任何能够表达的核酸。核酸可以被表达从而产生腺病毒。腺病毒可能是感染性的和/或可以自我复制的(例如复制型的)。在一些实施方案中，核酸是质粒。
在一些实施方案中，组装包括将腺病毒基因模块(或大模块)组合在一起形成核酸，其中腺病毒模块或大模块的方向有助于在导入细胞时形成有复制能力的腺病毒(例如能够在细胞内表达或形成病毒)。因此，在一些实施方案中，腺病毒基因模块(例如大模块)被组装成特定的取向。可以采用任何适合的克隆技术，包括例如所谓的“gateway”技术和/或不依赖序列和连接反应的克隆技术(“SLIC”)。Gateway技术或者类似的技术采用位点特异性重组将来自一条核酸的核酸(例如DNA)片段交换为另一个。最终结果是将一个核酸序列插入了目标载体或质粒。这些技术和方法在文中一起被称为“位点特异性重组法”或者“SSR方法”。在SSR方法的一个这样的应用中，DNA片段被从入门载体转移到目标载体中，其结果是目标载体的繁殖(图9)。入门载体和目标载体一般含有重组位点。在一些实施方案中，入门载体是能够重组型的。在其他实施方案中，入门载体是能够杂交的。杂交型入门载体可能含有一或多个腺病毒基因模块，这些模块可以通过限制性酶切从入门载体中释放出来，从而释放出腺病毒基因模块。本文提供了吸取了gateway技术的SSR方法，可以将腺病毒基因模块插入目标载体从而形成核酸(例如核酸质粒)。使用gateway技术的一般方法在例如Sone et.al.,J Biotechnol.(2008)Sep 10；136(3-4):113-21、Hartley,et al.,GenomeRes.(2000),10,1788–1795和Sasaki,et al.,J.Biotechnol.(2004),107,233–243中有描述。
例如，使用SSR方法时，组装包括将重组型目标载体(例如包含重组位点核酸序列的目标载体)和一或多个腺病毒基因模块与整合酶(例如λ噬菌体整合酶、λ噬菌体切除酶或细菌宿主的整合因子)接触，从而形成腺病毒基因模块载体。所述一或多个腺病毒基因模块是有重组能力的腺病毒基因模块(例如包含重组位点核酸序列的腺病毒基因模块)。在一些实施方案中，一或多个有重组能力的腺病毒基因模块是通过给腺病毒基因模块添加重组位点核酸序列，从而形成一或多个重组型腺病毒基因模块。在其他实施方案中，一或多个有重组能力的腺病毒基因模块是重组型入门载体的一部分。在一些实施方案中，含有一或多个腺病毒基因模块的重组型入门载体是通过将一或多个有重组能力的腺病毒基因模块和重组型供体载体与整合酶接触形成，从而形成含有一或多个腺病毒基因模块的重组型入门载体。因此，在一些实施方案中，重组型目标载体和含有一或多个腺病毒基因模块的一或多个重组型入门载体与整合酶活性接触，从而形成腺病毒基因模块载体。
图20-21示意了本文提供的建立人Ad5的方法的实施方案。组装包括将目标载体和各含有腺病毒基因模块的一或多个入门载体与一或多个λ噬菌体整合酶、λ噬菌体切除酶或细菌宿主的整合因子组合，从而形成腺病毒基因模块载体。在一些实施方案中，入门载体是通过给腺病毒基因模块添加重组位点，然后将供体载体和一或多个λ噬菌体整合酶、λ噬菌体切除酶或细菌宿主的整合因子组合，从而形成腺病毒基因模块入门载体。
目标载体是腺病毒基因模块与之连接的核酸，比如质粒。所述连接可能是通过含有要包含(插入)到目标载体中的腺病毒基因模块的一或多个入门载体的交换进行的。在与重组型目标载体和一或多个腺病毒基因模块与整合酶(例如整合酶、切除酶和/或宿主整合因子)接触(例如组合)之前，目标载体中可能存在一或多个腺病毒基因模块。
重组位点核酸序列，文中又称为“att”位点是协助两个核酸之间进行体外位点特异性重组的核酸序列。在一些实施方案中，重组位点核酸序列大约长21bp。例如，重组位点核酸序列可能是gateway重组信号，比如图10所示的和/或Sone et.al.,J Biotechnol.(2008)Sep 10；136(3-4):113-21；Hartley,et al.,Genome Res.(2000),10,1788–1795和Sasaki,et al.,J.Biotechnol.(2004),107, 233–243中给出的(例如attB位点、attL位点、attR位点、attP位点、attBr位点、attPr位点等)。
在一些实施方案中，一或多个有重组能力的腺病毒基因模块形成供体载体的一部分(或者存在于供体载体中)。所述供体载体可以是与gateway技术或者相似类型的克隆技术相容的质粒。
在一些实施方案中，DEST载体含有不同反选盒。反选盒是在某些条件下阻止细菌细胞生长的任何DNA片段。图22描述了本文提供的方法中使用的各种反选盒的效率。
图19详细描述了利用多位点gateway策略，重组Ad5腺病毒基因模块的原始方案。这个具体策略涉及四个入门载体的组合，其中三个是腺病毒基因模块，第四个是无关的填充模块。这四个模块一经组合，即可通过gateway反应除去填充模块从而形成目标载体。最后，通过gateway反应插入其余两个腺病毒基因模块得到完整的病毒基因组。当gateway反应中使用的是较大的腺病毒基因模块时，这个原始方案效率不高，并且存在Ad5 E1模块带来的毒性问题。组合方法(例如SLIC和SSR方法)使得更容易由模块组装基因组(例如，进行的步骤更少，每个步骤效率更高)。
SLIC技术通过依靠两个核酸(例如DNA片段)中由外切核酸酶生成的单链核酸(例如DNA)突出，进行了单链同源序列的退火(图16)。因此，SLIC技术采用依靠在插入核酸(例如DNA)和目标载体中由外切核酸酶生成的单链核酸(例如DNA)突出进行的同源重组和单链退火(例如杂交)。本文提供的方法采用SLIC技术将腺病毒基因模块插入到目标载体中从而形成核酸(例如核酸质粒)。这个过程在文中还被称为AdSlic或AdSlicR。例如Li et al.,Nature Methods(2007),4,251-256中描述了使用SLIC技术的一般方法。图25示意了给人Ad5建立的AdSlicR的例子。图26详细描述了AdSlicR方法中反应的效率。
例如，使用SLIC技术(或类似的克隆技术)的情况中，组装包括将(例如每个末端)带有单链核酸(例如DNA)突出的可杂交型目标载体(例如目标载体(例如线性载体))与一或多个腺病毒基因模块进行杂交(例如退火)，从而形成腺病毒基因模块载体。所述可杂交型目标载体在文中还可以被称为SLIC型载体。所述一或多个腺病毒基因模块可以是可杂交型腺病毒基因模块(例如，这样的腺病毒基因模块(例如，线性腺病毒基因模块)，所述模块(在例如每个末端)带有至少一个单链核酸(例如DNA)突出能够有效地与目标载体上的单链核酸(例如DNA)突出互补，从而协助(在例如严紧条件下)杂交)。在一些实施方案中，目标载体突出和腺病毒基因模块突出各种长大约20到25bp。可杂交型目标载体可以利用任何合适的方法形成。
例如，在一些实施方案中，当目标载体是环形的(例如质粒)，将目标载体(例如利用内切核酸酶)切割形成线性目标载体。任何将线性目标载体与外切核酸酶(即具有外切核酸酶活性的酶，比如T4DNA聚合酶)接触，从而形成可杂交型目标载体。类似地，可以通过将腺病毒基因模块与外切核酸酶接触(例如处理)而形成可杂交型腺病毒基因模块。在一些实施方案中，可杂交型目标载体与一或多个腺病毒基因模块的杂交可能包括将可杂交型目标载体和腺病毒基因模块与DNA聚合酶合并在一起。在一些实施方案中，当腺病毒基因模块是环形或者包含在环形质粒中时，在外切核酸酶处理前通过内切核酸酶将腺病毒基因模块线性化。因此，在一些实施方案中，一或多个可杂交型腺病毒基因模块是通过将包含一或多个入门载体腺病毒基因模块的入门载体与内切核酸酶接触，从而形成一或多个释放出来的入门载体腺病毒基因模块。所述一或多个释放出来的入门载体腺病毒基因模块可以与外切核酸酶接触，从而形成一或多个可杂交型腺病毒基因模块。文中提到的入门载体腺病毒基因模块是作为入门载体的一部分的腺病毒基因模块。文中提到的释放出来的入门载体腺病毒基因模块是由例如限制性内切酶从入门载体上释放出来的腺病毒基因模块。在一些实施方案中，腺病毒基因模块不是环形的(例如通过PCR或基因合成获得的)，不需要在外切核酸酶处理前进行线性化。在一些实施方案中，将SLIC型载体与一或多个腺病毒基因模块进行退火可能包括将SLIC型载体和腺病毒基因模块与DNA聚合酶组合。
在一些实施方案中，SLIC型载体在与SLIC型腺病毒基因模块退火前，含有一或多个腺病毒基因模块。因此在一些实施方案中，可以顺序进行多重SLIC反应来插入多重腺病毒基因模块。
在一些实施方案中，为了获得处于质粒中的腺病毒基因组以便作为产生腺病毒基因模块的模板，可以利用SLIC将整个腺病毒基因组插入质粒骨架。在一些实施方案中，SLIC型腺病毒基因组是从纯化的病毒保藏物中获得的。图30示意了这一过程的一个实施方案，并提供了人Ad5的例子。
腺病毒基因模块载体是含有至少一个腺病毒基因模块的核酸。利用合适的克隆技术，给目标载体添加所需数量的腺病毒基因模块，从而形成腺病毒基因模块载体。例如，一旦形成后，可以利用合适的克隆技术(例如gateway克隆技术和/或SLIC克隆技术)进一步改造腺病毒基因模块(例如腺病毒基因模块载体)，以便加入更多腺病毒基因模块，从而形成核酸，后者即可(在例如细胞内)被表达形成腺病毒(例如可以复制的腺病毒)。因此，在一些实施方案中，可以利用合适的克隆技术将第一个腺病毒基因模块进一步改造形成第二个、第三个和/或第四个腺病毒模块，其中分别向载体添加了第二、第三和/或第四腺病毒基因模块，从而形成了核酸，核酸经表达形成腺病毒(例如可复制的腺病毒)。因此在一些实施方案中，核酸是腺病毒基因模块载体。
的确，可以使用不同的克隆技术来组装核酸或腺病毒基因模块载体。在一些实施方案中，组装包括将可杂交型目标载体与第一腺病毒基因模块杂交(例如退火)从而形成第一腺病毒基因模块载体。第一腺病毒基因模块可能是可杂交型腺病毒基因模块。第一腺病毒基因模块载体可以和第二腺病毒基因模块入门载体与整合酶(例如整合酶、切除酶或者宿主整合因子)进行接触(例如合并)，从而形成第二腺病毒基因模块载体。第二腺病毒基因模块载体可能是可重组型第二腺病毒基因模块载体(例如目标载体)，第二腺病毒基因模块可能是可重组型第二腺病毒基因模块。在一些实施方案中，第一腺病毒基因模块是E2-L2模块、L3-L4模块或者E2-L4大模块。第二腺病毒基因模块可以是E1模块、E3模块或者E4模块。图20-21提供了联合使用克隆方法来组装腺病毒基因模块的例子，其中联用了SLIC和gateway。
在其他实施方案中，组装包括将可重组型目标载体和第一腺病毒基因模块与(在有)整合酶(例如，整合酶、切除酶或者宿主整合因子)进行接触(例如合并)，从而形成第一腺病毒基因模块载体。第一腺病毒基因模块是可重组型第一腺病毒基因模块(例如入门载体)。第一腺病毒基因模块载体与第二腺病毒基因模块杂交，从而形成第二腺病毒基因模块载体。第一腺病毒基因模块载体是可杂交型腺病毒基因模块载体(例如目标载体)。第二腺病毒基因模块是可杂交型腺病毒基因模块(例如入门载体)。在一些实施方案中，第二腺病毒基因模块是E2-L2模块、L3-L4模块或者E2-L4大模块。第一腺病毒基因模块可以是E1模块、E3模块或者E4模块。
在一些实施方案中(例如人Ad5的例子中)，E2-L2模块和L3-L4模块分别大约14kb和10kb。文中提供的一个发现是E2-L2和L3-L4模块的大小太大，在一些实施方案中利用标准或者gateway(例如多位点gateway)克隆技术不能有效地组装为核酸。图15中提供了例子。因此在一些实施方案中，SLIC克隆技术(或类似的克隆技术)被用来将这些模块插入到目标载体(例如入门载体)中。利用例如gateway克隆技术添加其他腺病毒基因模块。因此在一些实施方案中，当E2-L2模块和L3-L4模块被组装为核酸时，优选联用SLIC和gateway(例如多位点gateway)克隆策略来组装核酸。图20-21中给出了SLIC和gateway(例如多位点gateway)克隆策略联用的特定实施方案。
本文提供的方法的某些实施方案实现了快速有效的腺病毒基因组构建体的组装。一些情况中，腺病毒基因组构建体在不到10、9、8、7、6、5、4、3、2或者1个小时内即可组装好。本文提供的方法还使得可以进行腺病毒片段到载体的插入、在个别载体内进行的简单独立突变、和/或多位点特异性体外组装。
如下文所述，在一些实施方案中，一个或全部腺病毒基因模块可能选自重组腺病毒基因模块库。因此，Adsembly过程的某些实施方案能够快速有效地构建多种重组腺病毒，从而可以根据腺病毒基因模块的最佳组合快速优化定制腺病毒的功能性。因此方法提供了通过将来自各种腺病毒血清型的部分进行混合和匹配以制备新的腺病毒血清型嵌合体的能力。这使得不仅能将每个血清型的独特属性结合在一起，而且能够利用到血清型的不同向性以及避开对流行血清型已有的免疫能力的可能性。
本文提供的方法的某些实施方案避免了对有限的限制酶位点克隆技术的依赖性。方法还可以避开对腺病毒血清型5的单一依赖性。确实在人Ad5的例子中，当采用了E1模块、E2-L2模块、L3-L4模块、E3模块和E4模块所有5种模块时，相对以前的已知方法突变体选择显著增加。在某些实施方案中，本文提供的方法能够在基因组中同时形成复合的变化。
所述方法还可能避开以前的单一依赖在专门化细菌菌株或哺乳动物细胞培养物(例如MAGIC)中经常需要几个月进行低效同源重组的已知基因组组装方式。而且，本文提供的方法的某些实施方案给出了简单的试验方案，只需常见试剂而无需使用专门的细菌(例如ccdB抗性)。
本文提供的方法和文库的用途包括例如:
(1)为了基因功能分析而进行的腺病毒基因的突变，
(2)获得腺病毒突变体，其中腺病毒基因功能的丢失使它们不能在正常细胞内复制，但在能够补充其功能的肿瘤细胞中可以选择性地发生裂解性复制。
(3)靶向基因表达，作为复制缺陷型载体或者可复制型病毒。
(4)方法可以提供用于基因表达的新的复制缺陷型腺病毒。可以将利用文中所述方法组装的腺病毒为了这个目的进行优化。在人Ad5的情况中，E1模块文库可能包括例如多个E1A或E1B缺失的模块和/或每个含有不同的哺乳动物启动子从而允许使用者能够选择最佳启动子来表达目的基因。
(5)利用已有的腺病毒基因组转录构架进行多基因表达。
在E1模块、E2-L2模块、L3-L4模块、E3模块和E4模块中每一种都运用了的实施方案中，只有E4模块中不存在突变。
可以利用任何适宜的方法(例如PCR技术或者基因合成)，从任何合适的腺病毒获得E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块以及它们的大模块。例如，可以用从纯化病毒获得的病毒基因组DNA进行PCR(图14)。图13详细描述了人Ad5腺病毒基因模块的PCR效率。在一些实施方案中，E1模块、E2-L2模块、L3-L4模块、E3模块和E4模块的组合构成了或者它们的大模块构成了完整的或者基本完整的腺病毒基因组。利用文中提供的教导，本领域技术人员可以确定模块之间中断处的确切位置。例如，可以利用生物信息学手段确定重组位点核酸序列(例如，gateway重组信号或者gateway重组位点)的最佳插入位点。可以将多个腺病毒血清型进行比对，并在腺病毒基因模块之间进行基因组区域的保守性分析。在一些实施方案中，避开了血清型之间的核苷酸保守区，而简并区域是可以接受的插入位点。例如，图12、图35、图36、图37和图38中箭头指示了人Ad5中某些适宜的重组位点核酸序列的插入位点。
在一些实施方案中，腺病毒基因模块之间的序列可能较短，因此需要序列的重复。图12提供了一个例子，其中由于Ad5纤维蛋白polyA和E4polyA之间的序列短，与attB位点插入一起插入了一个27bp的Ad5序列重复。
在一些实施方案中，核酸(例如腺病毒基因模块载体)包含一或多个重组位点核酸序列。图35-39中公开了一些例子，但这些例子不是意图限制重组位点核酸序列在重组腺病毒中的核酸序列位置如何影响重组腺病毒的生长速率。因此在一些实施方案中，包含一或多个重组位点核酸序列(例如att位点)的重组腺病毒可能比没有一或多个重组位点核酸序列的重组腺病毒生长地慢。在其他实施方案中，包含一或多个重组位点核酸序列(例如att位点)的重组腺病毒可能与没有一或多个重组位点核酸序列的重组腺病毒生长地至少一样快。在其他实施方案中，核酸(例如腺病毒基因模块载体)包含位于E3模块和E4模块之间的重组位点核酸序列。在一些实施方案中，E3模块和E4模块之间的重组位点核酸序列是attB3重组位点核酸序列。在一些实施方案中，核酸(例如腺病毒基因模块载体)包含位于如SEQID NO:137中给出的核苷酸32904之后的或者位于所述序列同源物中的等同核苷酸之后的重组位点核酸序列。在其他实施方案中，核酸(例如腺病毒基因模块载体)包含位于E1模块和E2-L2模块之间的重组位点核酸序列。在其他实施方案中，核酸(例如腺病毒基因模块载体)包含位于如SEQ ID NO:137中给出的核苷酸4035之后的或者位于所述序列同源物中的等同核苷酸之后的重组位点核酸序列。在其他实施方案中，核酸(例如腺病毒基因模块载体)包含位于如SEQ ID NO:137中给出的核苷酸3608之后的或者位于所述序列同源物中的等同核苷酸之后的重组位点核酸序列。在一些实施方案中，核酸(例如腺病毒基因模块载体)包含位于L3-L4模块和E3模块之间的重组位点核酸序列。在一些实施方案中，L3-L4模块和E3模块之间的重组位点核酸序列是attB5重组位点核酸序列。在其他实施方案中，核酸(例如腺病毒基因模块载体)包含位于E1模块和E2模块之间的第一重组位点核酸序列、L3-L4模块和E3模块之间的第二重组位点核酸序列、E3模块和E4模块之间的第三重组位点核酸序列。在其他实施方案中，第一重组位点核酸序列包含在核酸中如SEQ ID NO:137中给出的核苷酸4035之后或者所述序列的同源物中等同核苷酸之后，第三重组位点核酸序列包含在核酸中如SEQ ID NO:137给出的核苷酸32904之后或者所述序列同源物中等同核苷酸之后。
以下列出的插入策略的例子显示了Ad5基因组(SEQ ID NO:137)中的四个插入。数字表示已公开的Ad5基因组序列中重组位点核酸序列插入所位于的核苷酸位点。在以下例子中，attB序列(即重组位点核酸序列)带有下划线，最后一个插入的Ad5序列重复显示为粗体。本领域技术人员很容易识别相似情景中或者同源病毒序列中合适的和/或等同的插入位点。
4075和4076之间的:
CAACTTTTCTATACAAAGTTGTA
17959和17960之间的:
CAACTTTTTAATACAAAGTTG
27173和27174之间的:
TCAACTTTGTATACAAAAGTTGTG
32815和32816之间的:
ACAACTTTGTATAATAAAGTTGCT
图21中的组装策略被使用17次来产生感染性人Ad5病毒。图24详细描述了本文提供的方法的效率。在四个独立情景中，野生型Adsembled腺病毒被转染至细胞内，产生了病毒。此外，该实验方案生成了13个突变体腺病毒，全部能够产生感染性病毒。图27提供了由转染重组装得到的表现为单个噬菌斑并且在293细胞上进行了传代的野生型Ad5的图像。由图20-21和图25中的策略产生的病毒在293细胞中测试了复制效率，如图28所示。
另一方面，提供了通过本文公开的方法制备的腺病毒。在一些实施方案中，腺病毒是可复制型的。在另一个实施方案中，腺病毒不是可复制型的。
II.腺病毒基因模块和大模块文库
另一方面，提供了包含复数个腺病毒基因模块(例如大模块)的文库。在一些实施方案中，文库包含复数个不同E1模块。在其他实施方案中，文库包含复数个不同E2-L2模块。在其他实施方案中，文库包含复数个不同L3-L4模块。在其他实施方案中，文库包含复数个不同E3模块。在其他实施方案中，文库包含复数个不同E4模块。在其他实施方案中，文库包含复数个不同核心大模块。在一些实施方案中，根据以上描述的方法制备了腺病毒基因组文库。
在其他实施方案中，文库包含复数个不同E1模块、复数个不同E2-L2模块、复数个不同L3-L4模块、复数个不同E3模块、复数个不同E4模块和/或复数个不同核心大模块。在一些实施方案中，文库包含复数个不同大模块，其中所述大模块包含复数个不同E1-L2大模块、复数个不同E2-L4大模块(即核心大模块)和/或复数个不同E3-E4大模块。
在一些实施方案中，复数个不同腺病毒基因模块和/或大模块区别在于它们来源于不同的腺病毒类型(例如不同种或者不同血清型)。例如，在一些实施方案中，复数个不同E1模块、复数个不同E2-L2模块、复数个不同L3-L4模块、复数个不同E3模块、复数个不同E4模块和/或复数个不同大模块(例如核心大模块)包含来自复数个腺病毒类型(例如一个以上人腺病毒血清型)的腺病毒基因模块。
在一些实施方案中，复数个不同腺病毒基因模块和/或大模块区别在于它们编码不同的突变体模块或大模块(例如缺失的腺病毒核酸序列、取代的腺病毒核酸序列、异常的腺病毒核酸序列或者编码非腺病毒基因产物的核酸序列)。例如，文库可能包含复数个不同的E1模块、复数个不同的E2-L2模块、复数个不同的L3-L4模块、复数个不同的E3模块、复数个不同的E4模块或者复数个不同的大模块(例如核心大模块)，所述模块包含缺失的腺病毒核酸序列、突变的腺病毒核酸序列、异常腺病毒核酸序列或者编码非腺病毒基因产物的核酸序列。
在一些实施方案中，复数个不同的腺病毒基因模块和/或大模块是可重组型的(例如，包含在入门载体中)。例如，文库可以包含可重组型的复数个不同的E1模块、复数个不同的E2-L2模块、复数个不同的L3-L4模块、复数个不同的E3模块、复数个不同的E4模块和/或复数个不同的E2-L4大模块。
在一些实施方案中，复数个不同的腺病毒基因模块和/或大模块是可杂交型的(例如比如线性化后是SLIC型的)。例如，在一些实施方案中，文库包含可杂交型的复数个不同的E1模块、复数个不同的E2-L2模块、复数个不同的L3-L4模块、复数个不同的E3模块、复数个不同的E4模块和/或复数个不同的E2-L4大模块。
本文提供的文库的部分可以由不同使用者制备，在不同使用者之间共享。可以将各种腺病毒基因模块混合和匹配构建具有所需功能或者没有某功能的新的腺病毒构建体。因此本文的方法和文库提供了通过将来自各种腺病毒血清型的部分进行混合和匹配以制备新的腺病毒血清型嵌合体的能力。腺病毒基因模块文库给使用者提供了构建理想腺病毒载体的多项选择。
在一些实施方案中，腺病毒基因模块可能对细菌是有毒的。例如，图18显示了人Ad5 E1模块的毒性。在一些实施方案中，可能需要将腺病毒基因模块包含在以低拷贝数维持的质粒中(例如p15A复制原点)。
在一些实施方案中，腺病毒基因模块毒性、大小或者其他因素可能会妨碍它们在SSR方法(例如gateway反应)中的用途。例如，图15详细描述了5个人Ad5腺病毒基因模块的标准gateway BP反应效率。在一些实施方案中，使用SSR方法(例如gateway反应)效率低的腺病毒基因模块可以通过替代的克隆方法(例如SLIC)来操作。图17示意了用SLIC代替SSR方法(例如利用gateway克隆酶)来制备入门载体的策略。
III.试剂盒
另一方面，提供了供本文描述的方法和文库使用的试剂盒，所述试剂盒包含含有选自E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或者腺病毒大模块(或者如下所述的它们的突变体)的两个或更多个腺病毒基因模块的核酸。试剂盒的合适成分包括以上I和/或II部分中讨论过的组合物和成分。
例如在一些实施方案中，试剂盒可能包含核酸，所述核酸含有选自E1模块、E2-L2模块、L3-L4模块、E3模块、E4模块或者腺病毒大模块中的3、4或5个腺病毒基因模块。正如上文讨论过的，核酸可能构成载体(例如质粒)(例如目标载体或供体载体)的一部分。
在一些方面中，本文提供的试剂盒可能包含带有或者没有腺病毒基因模块的载体。可用于试剂盒的载体可能包含一或多个重组位点核酸序列和/或单链核酸突出(或者在与合适的酶接触时能够形成单链核酸突出的核酸序列)。在一些实施方案中，载体是如上所述的可杂交型的目标载体、SLIC型载体或者供体载体。载体可以包含一或多个腺病毒基因模块。在一些实施方案中，载体中包含反选盒。
参考本文对Adsembly方法和文库的描述，用于实施本文提供的方法的试剂盒的其他成分是显而易见的(例如外切核酸酶、整合酶、启动子序列等)。
IV.实施例
以下实施例仅供阐释而非限制要求保护的发明。
A.病毒组装方法
1.“组合”化学和“重组”病毒基因组以开发新一代病毒载体和复制裂解性癌症疗法
我们开发了由组成部分快速离体组装病毒基因组的新的重组策略，从而能够对多重修饰和异源元件进行系统地组合。
腺病毒载体的多种应用潜能受限于快速和系统地改造和组合多重基因修饰的能力。当前使用的方法主要依赖于基因组中在合适位置上存在的独特的合适限制酶位点，一般来说不适合系统地使用或者不能在快速的单一步骤中生成准确的复合修饰。大基因组DNA片段的操作和缺乏独特的限制位点使这种方法有技术上的难度和受到限制。另一种方法需要生成带有要改造基因组区域的小“穿梭”载体，和带有病毒基因组的“骨架”载体。对这些载体来说主要限速步骤是重组，所述重组或者是在哺乳动物细胞内通过同源重组发生的(概率非常小的事件，发生在随机位点，需要进行多轮噬菌斑纯化来分离所需的重组体)，或者是在特殊的细菌菌株中通过同源重组发生的。这些方法有它们的局限性。
为了克服目前技术的局限性，我们开发了新的腺病毒基因组组装策略，使得能够快速和系统地过夜生成复合病毒突变体。这样可以省略在哺乳动物细胞内进行的低效不准确重组、对BACs或穿梭载体的需要、费时费力的噬菌斑纯化。这个策略提供了由组成部分快速体外组装新的病毒基因组的能力，包括:1)对病毒基因的多重突变/修饰；2)来自其他病毒亚型的基因(例如结合不同受体的病毒外壳蛋白)，和改变血清型；3)异常基因，例如前药转化酶以便诱发强力的肿瘤旁观者效应；4)添加荧光报告物或标签用于体内造影和诊断，以及5)定向体外病毒进化。此外，这项技术利用了天然的病毒转录构架，对于人Ad5它编码了36个基因(不包括剪接变体)，因此多蛋白复合体和整个途径可以经由腺病毒感染来组装、递送和共表达。
为了克服Ad2/5和目前的方法学的局限，我们开发了Adsembly方法，使得能够体外由基因组组成部分和异源元件快速离体组装腺病毒基因组。利用生物信息学手段，我们根据进化保守序列、转录和功能模块，将不同腺病毒基因组(36-38kb)分为5个单位。这5个单位的每一个包含基因组构成成分文库的相容部分，通过突变或异源元件的加入可以改变它们的功能和多样性，并且这些功能和多样性可以通过添加来自完全不同的腺病毒血清型、突变体和种的等同单位进一步扩展。为了制备具有独特性能的新腺病毒，从文库中选择每个单位各一个，利用Adsembly(例如Ad-SlicR)快速体外重新组装成完整基因组。可以利用Adsembly通过多位点特异性重组来组装新的基因组，所述基因组在转染后，即从质粒骨架上自我剪接并复制产生新的病毒。可以利用Ad-SlicR策略除去插入的重组序列以便实现更强力的病毒复制(如果需要)和临床应用。本文公开的策略可以使用基因组构成元件文库，所述文库是由具有不同Ad2/5向性和其他所需特性的人和/或动物腺病毒制备的或者已经经过基因改造被赋予了改变的功能性。
为了实现这一目的，我们利用了经过修饰，特异性和效率得以提高的噬菌体位点特异性重组系统，又被称为Gateway。被命名为attB、attP、attL和attR的四类重组位点经由不同噬菌体酶进行重组。最近鉴定到了新的att位点特异性，可以允许多个DNA片段以一定的顺序和方向进行同时重组。本文公开的是该系统的新应用，即由基因组组成部分离体组装整个病毒基因组。令人惊讶的是这项技术革新了腺病毒载体的建立和潜在应用。
使用引入了独特attB位点(编号1-6)对的引物组来扩增与之匹配的相邻病毒基因组。Ad5腺病毒基因组长36kb，暂时划分为“早期”(E)和“晚期”(L)转录单位，它们共同编码36-40个基因。
野生型Ad5/2、Ad5/2的突变体和完全不同的腺病毒亚型或动物 病毒被用做DNA模板。将PCR片段重组到“入门”载体中生成含有腺 病毒基因组组成元件的文库。LR重组到目标载体中使得个体元件多 种排列组装成新的病毒基因组。通过对目标载体的抗生素抗性进行的 阳性选择和对大肠杆菌中未反应目标载体进行的阴性选择(毒性基因 ccdB提供的(Hartley et al.,2000))来协助这一过程。对于片段的数量或 大小限制了重组效率的情况，制备了中间目标载体，其中的第二 BP/LR反应中发生modular replacement或者完全组装。该快速病毒 DNA操作新方法通过利用DNA重组的固有化学属性改变了新病毒 的工程化过程。还引入了其他组合，例如，腺病毒34纤维蛋白，该 蛋白与CD46细胞受体结合，能够规避针对Ad2/5病毒产生的中和抗 体。
2.材料与方法
采用以上指导方针，用以下参照成分制备了经过改造的腺病毒。使用了GatewayDONR载体。在人Ad5的例子中，经PCR获得E1模块并利用SLIC插入载体pDONR P1P4。利用PCR扩增包含attL1和attL4重组位点的pDONR P1P4载体骨架，并通过SLIC与Ad5 E1模块组合。为了制备替代的反选盒，对载体pDONR P1P4进行了改造。包含attP1和attP4重组位点的该载体骨架利用PCR扩增，并与PheSA294G突变和四环素抗性盒(来自pENTR L3-pLac-Tet-L2的pLac-Tet盒)组合形成新的DONR载体。然后经PCR扩增新DONR载体中的attR1-PheSA294G-Tet(r)-attR4片段，并插入到Adsembly DEST载体中。参见“MultiSitePro Plus”,Cat#12537-100和Sone,T.et al.J Biotechnol.2008Sep 10；136(3-4):113-21。
在人Ad5的例子中，E3模块经gateway BP反应插入pDONR P5P3r载体。E4模块经gateway BP反应插入pDONR P3P2载体。来自pDONR P5P2载体的attR5-ccdB-Cm(r)-attR2片段经PCR扩增，插入Adsembly DEST载体中。参见“MultiSitePro Plus”,Cat#12537-100；and Sone,T.et al.JBiotechnol.2008Sep 10；136(3-4):113-21。
用于Adsembly DEST载体的载体骨架是由来自三个不同来源的部分构成的。Amp(r)盒和lacZ基因是从质粒pUC19扩增的。将它们与p15A复制原点组合，所述复制原点来自质粒pSB3K5-I52002(BioBricksiGEM 2007 parts distribution的一部分)。使质粒保持在较低(10-12)拷贝数的p15A ori是减少E1毒性所需要的。最后，为了产生能够自身切除的病毒，从pAdZ5-CV5-E3+质粒PCR I-SceI酶的哺乳动物表达盒。将该盒克隆到载体骨架中形成被称为p15A-SceI的载体。这是启动基因组组装所使用的载体。在Ad5的例子中，基因模块全部得自由野生型Ad5病毒纯化的DNA或者质粒pAd/CMV/V5/DEST(Invitrogen)。
对于人Ad5例子中的DEST载体，将E2和L3模块通过3片段SLIC插入质粒p15A-SceI。旁侧带有attR5和attR2位点的表达ccdB的反选标记物和Chlor(r)通过PCR从质粒pDONRP5P2获得。第二反选标记物(PheS-Tet)是经PCR从载体pDONR P1P4PheSA294G-Tet(见上文)获得。将这两个反选标记物用加在E2和L4模块末端的独特限制酶切割后，通过SLIC插入p15A-SceI E2-L4的右侧(ccdB/Cm)和左侧(PheS/Tet)从而形成DEST载体。
对于人Ad5的例子中含有腺病毒基因模块的多位点gateway入门载体，将E1模块通过SLIC插入pDONR P1P4。E3模块通过gateway BP反应插入pDONR P5P3R。E4模块经gatewayBP反应插入pDONR P3P2。
对于Amp(r)盒:质粒pUC19、p15A ori:质粒pSB3K5-I52002是BioBricks iGEM2007parts distribution的一部分。腺病毒基因模块或者是来自由Ad5毒粒纯化的DNA或者是质粒pAd/CMV/V5/DEST(Invitrogen)。DONR载体pDONR P1P4、P5P2、P5P3R、P3P2来自JonChesnut(Invitrogen)。PheS基因来源于DH5alpha细菌基因组DNA，随后通过Quickchange形成PheSA294G突变体。对于Tet(r)基因，质粒pENTR L3-pLac-Tet-L2来自Jon Chesnut(Invitrogen)。
对于Adsembly方法的实施方案，将20fmol双DEST载体(一般含有旁侧带有两个反选盒的核心模块)与其余含有基因模块的入门载体各10fmol组合。在Ad5的例子中，这包括将20fmol E2-L3双DEST载体与各10fmol的E1模块入门载体、E3模块入门载体和E4模块入门载体组合。在一些情况中，增加一或多个入门载体的量可能提高效率(例如，给Ad5使用50fmolE1模块入门载体)。将这些载体与2μl LR Clonase II(Invitrogen)在终体积10μl中组合。反应于25℃过夜(12-16小时)温育。加入1μl蛋白酶K(Invitrogen)并在37℃温育10分钟来终止反应。然后取5μl反应转化至对ccdB基因产物敏感的高感受态细菌(>1e9cfu/μg)，并铺在YEG-Cl琼脂板(如Kast,P.Gene,138(1994)109-114中所描述的使用PheSA294G反选时)或者其他对于载体使用的反选来说合适的培养基上。
对于PCRs，所有PCR均使用Phusion酶(NEB)进行。由Ad5获得腺病毒基因模块的PCR用1x HF缓冲液、dNTP各200μM、引物各0.5μM和10ng模板进行。对于E2-L2模块，还添加了3％DMSO。模板是质粒pAd/PL-DEST(Invitrogen；对于E2-L2、L3-L4和E4模块)或者Ad5基因组DNA(对于E1和E3模块)。PCR条件如下。对于E2-L2和L3-L4:98℃30秒–98℃10秒、65℃30秒(每2个循环降低1℃)，72℃7分钟，10个循环-98℃10秒、60℃30秒、72℃8分钟，29个循环-72℃10分钟–保持在4℃。对于E3:98℃30秒-98℃10秒、70℃30秒(每个循环降低0.5℃)、72℃2分30秒，10个循环-98℃10秒、68℃30秒、72℃2分30秒，25个循环-72℃10分钟-保持在4℃。对于E4:98℃30秒-98℃10秒、63℃30秒(每个循环降低0.5℃)、72℃2分钟，6个循环-98℃10秒、60℃30秒、72℃2分钟，29个循环-72℃5分钟-保持在4℃。
对于由纯化的病毒获得病毒基因组DNA，将最多100μl纯化病毒加入300μl含有10mM Tris pH8、5mM EDTA、200mM NaCl和0.2％SDS的裂解缓冲液。混合液于60℃温育5分钟，之后加入5μl蛋白酶K储液(～20mg/mL)，在60℃继续温育1小时。然后将样品置于冰上5分钟，随后于15K x g转15分钟。取上清液加入等体积的异丙醇、混合均匀，15K x g于4℃旋转15 分钟。沉淀用70％乙醇洗涤，再次4℃旋转15分钟。将沉淀干燥，重悬待用。
对于SLIC，线性片段用外切核酸酶于室温下在如下20μl反应中处理20分钟:50mMTris pH8、10mM MgCl2、50μg/mL BSA、200mM脲、5mM DTT和0.5μl T4DNA聚合酶。加入1μl0.5M EDTA并在75℃温育20分钟来终止反应。然后将等量的T4处理的DNA在新试管中混合至20μl。对于组合两个片段的SLIC，每个反应各使用10μl。对于组合三个片段的SLIC，每个反应各使用7μl。通过加热至65℃10分钟，然后每5秒降低0.5℃缓慢冷却至25℃使片段退火。退火后，取5μl反应进行转化并筛选克隆。
对于用于例如Ad5的AdSlicR，使用100ng T4处理的p15A-SceI(经PCR线性化)和各300ng的E2和L3模块(由它们各自的入门载体经PCR获得)进行3片段SLIC反应。这产生了载体p15A-SceI E2-L4。5μg p15A-SceI E2-L4用SwaI切割并使用Qiagen QiaexII凝胶纯化。E3和E4模块由它们各自的入门载体经PCR获得。将各个被线性化的载体(450ng)和PCR产物(200ng)用T4DNA聚合酶处理，用150-200ng载体和～100ng各模块PCR正常进行SLIC。分离阳性克隆，取5μg新载体用PacI切割并凝胶纯化，然后与E1PCR产物(100ng T4处理过的)在新的SLIC反应中组合。基因组组装至此完成，质粒可用于转染来重建病毒。
B.经过改造的腺病毒
腺病毒常用于基因转移的用途。例如，它们被用于将转基因递送给培养物中的细胞、体内动物组织或者对于基因治疗递送递送给体内人类细胞。这种方式使用腺病毒的一个限制因素是基因表达只是暂时的。腺病毒是非整合型病毒，因此一旦发生细胞分裂就会丢失转基因的表达。其他能够发生整合的病毒系统，比如逆转录病毒和慢病毒，被用于同样的基因转移目的。但是，这些天然具有整合能力的病毒较小，因此限制了可以表达的转基因的量，很难生长到高滴度，难以由它们表达多个转基因，而且它们会整合到基因组中的随机位置。
已有试验表明PhiC31整合酶可以介导含有～280bp attB序列的外来环形DNA整合到宿主细胞染色体中的特定位置，被称为假性attP位点。已经使用环形质粒DNA展示了这个过程，但还没有在诸如腺病毒的病毒中证明，可能是因为腺病毒基因组是线性的，因此或者不发生整合或者整合导致染色体断裂。这里我们提供了可以这样形成重组腺病毒基因组的系统，所述系统在转导后，基因组的一部分经由cre介导的loxP位点重组变成环形，从而使得可以通过PhiC31整合酶/attB进行定向整合。
对于这项技术，以多种方式将腺病毒基因组进行了改造(参见图31-33)。首先，删除了E1和E3区以便表达多个转基因。E4区被表达cre重组酶和PhiC31整合酶的盒代替。利用tet-反应性启动子或其他类似的可调控元件来调节这些酶的表达。基因组中安置了两个loxP位点，一个在E1区的左端表达转基因的地方，第二个位于纤维蛋白和E4区之间。因此位于两个loxP位点之间的全部都被插入到细胞染色体中。最后，在E3区内安置PhiC31attB位点，虽然可以将这个短序列安排在其他位置只要是位于loxP位点之间(虽然本实施例中cre重组酶和PhiC31整合酶是由含有loxP位点和转基因的同一个腺病毒表达的，也可以由分开的病毒表达这些酶)。
在腺病毒被转导到细胞中时，cre重组酶和PhiC31整合酶被诱导。Cre协助腺病毒基因组中的loxP位点的重组。这导致位于loxP位点之间的DNA发生环化。然后这使得整合酶利用片段中的attB位点将环形片段重组到细胞染色体中(参见图33)。最终的结果是腺病毒基因组中选定的一部分被稳定(非回复性)整合到宿主细胞染色体中有限的几个位置之一。从这个整合片段稳定地表达转基因。没有腺病毒复制或复活的风险，因为1)E1区被删除和2)在这个过程中病毒基因组的末端被删除。这两个区域是病毒转录和复制所必需的。
该系统与现有逆转录病毒和慢病毒系统相比的优势包括1)在基因组内数量有限的位置发生整合，而不是随机整合，2)提高了转基因表达允许的大小，3)通过纤维蛋白修饰(图39-42)或者使用其他腺病毒血清型和种(图45)将腺病毒重新导靶到特异细胞或组织的能力，4)使用Adsembly系统操作的简易性，5)生产高滴度病毒的简易性和6)由单一载体进行多基因表达的简易性。
该系统通过利用病毒介导的DNA递送推进了目前的PhiC31整合技术(由LifeTechnologies以“Jump-In”产品线销售)。现有技术只是基于质粒的，因此局限于可以被有效地转染或电穿孔的细胞。而且不能体内使用除非生成特定的转基因小鼠。腺病毒被常规用于体内递送转基因，因此极大地扩展了现有技术的能力。一个体现是利用多基因表达盒通过将改造过的腺病毒可滴定地和定向地递送到特异组织中来产生小鼠模型。另一个体现是含有att位点以便进行靶向敲入的小鼠系。再一个体现是iPS。
C.利用ADSEMBLY制备完整的近乎野生型腺病毒5型
利用以下策略，使用Adsembly构建了Ad5的近乎野生型版本。将侧翼带有gateway反选盒的野生型核心序列与野生型Ad5 E1模块、野生型Ad5 E3模块和野生型Ad5 E4模块混合(图21)。分离到含有完全组装好的基因组的克隆并转染到293细胞中。7天后可以看到噬菌斑，收集病毒并在更多293细胞上扩增。生长分析显示该近乎野生型的病毒(与真正的野生型病毒相比，它含有3个attB插入)达到的滴度只比真正的野生型病毒略低(图28)。
D.复制缺陷型突变体AD5的制备，所述突变体表达GFP，含有来自另外的血清型的纤维蛋白
我们利用Adsembly制备了突变体Ad5。Ad5 E1模块经过改变，其中的E1A和E1B区被缺失，因此使得任何用这个新载体制备的病毒都是复制缺陷型的。除去E1A和E1B后，插入了含有CMV IE启动子和GFP基因的哺乳动物表达盒。Ad5 E3模块的改变是用来自Ad34的纤维蛋白基因代替Ad5纤维蛋白基因。将这些突变体E1和E3-纤维蛋白模块与侧翼带有gateway反选盒的野生型Ad5 E4模块和野生型Ad5核心模块在标准Adsembly反应中组合(图21)。分离到含有完全组装好的基因组的克隆并转染至293细胞中。7天后可以看到噬菌斑，收集病毒并在更多293细胞上扩增。该病毒的生长情况表明这一策略可以用于1)转基因表达，2)荧光基因表达，3)复制缺陷型病毒构建体,4)制备嵌合腺病毒，和5)在Ad5背景中的替代的纤维蛋白表达。
E.利用ADSLICR制备可复制型AD5
利用AdSlicR由腺病毒基因模块构建野生型Ad5。野生型E3和E4模块从它们的腺病毒基因模块载体经PCR获得。将它们与SwaI切割的野生型Ad5核心模块在标准SLIC反应中组合(图25)。分离到成功含有核心模块和E3和E4模块的克隆并用PacI进行切割。然后将其与通过PCR从腺病毒基因模块载体获得的野生型Ad5 E1模块在第二个SLIC反应中组合。分离到含有完全组装好的基因组的克隆并转染到293细胞中。到第7天有可见的噬菌斑。将得到的病毒在更多293细胞上进行扩增。对该病毒进行的生长分析显示它与野生型Ad5可以生长到同样的滴度(图28)。
V.表格
表1-9公开了利用本文提供的方法制备的腺病毒基因模块载体、目标载体和入门载体的例子。
序列表
<110> 萨克生物研究学院（THE SALK INSTITUTE FOR BIOLOGICAL STUDIES）
<120> 腺病毒组装方法
<130> 92150-816208
<150> US 61/374,198
<151> 2010-08-16
<160> 143
<170> PatentIn version 3.5
<210> 1
<211> 1149
<212> PRT
<213> 犬腺病毒1（Canine adenovirus 1）
<400> 1
Met Ser Leu Val Gln Ser His Gly Thr Ser Gly Leu Phe Thr Glu Pro
1 5 10 15
Pro Asn Ser Ile Asn Gln Gln Glu Ser Ser Gly Pro Ser Leu Pro Ala
20 25 30
Gln Asp Ala Thr Gln Ala Ser Ala Ser Ser Ala Arg Ala Gly Ala Thr
35 40 45
Pro Ala Ile Asn Ser Thr Lys Arg Lys Tyr Arg Gly Ala Val Val Ala
50 55 60
Gln Arg Ala Thr Leu Ser Ile Ser Ala Ile Leu Asp Asn Gly Gln Cys
65 70 75 80
Val Gln Ile Lys Tyr His Ser Asn Leu Ala Ser Ala Leu Thr Asn Leu
85 90 95
Cys Asn Thr Asn Leu Tyr Asp Leu Pro Ala Cys Leu Asn Lys Pro Ile
100 105 110
Thr Val His Asn Leu Pro Thr Leu Ile Glu Glu Ala Ala Ala Ser Tyr
115 120 125
Ser Leu Ile Tyr Tyr Tyr Gln Arg Gly Thr Val Arg Lys Val Glu Phe
130 135 140
Arg Ala Glu Ile Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val Lys
145 150 155 160
His Gly Lys Val Phe Leu Ile Lys Asp Ile Ser Pro Met Gln Arg Cys
165 170 175
Glu Phe Cys Gly Ser Phe Phe Lys Val Thr His Thr Cys Thr Leu Arg
180 185 190
Arg Arg Asp Phe Tyr Phe His His Val Ala Ser His Ser Gly Asp Trp
195 200 205
Trp Glu Lys Ile Ser Phe Ser Pro Ile Gly Ala Pro Ala Asn Thr Glu
210 215 220
Arg Leu Phe Ile Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Lys
225 230 235 240
Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu Leu Gly
245 250 255
Asp Glu His Leu Val Asn Ala Ala Lys Asn Leu Ala Thr Thr Gln Asn
260 265 270
Trp Asp Thr Trp Asn Ser Asn Glu Gln Thr Ala Leu Tyr Tyr Cys Ile
275 280 285
Thr Pro Glu Lys Arg Ala Ile Gly Val Lys Phe Lys Thr Phe Arg Asp
290 295 300
Thr Leu Gln Gln His Phe Ala Asn Asn Leu Trp Ser His Val Leu Cys
305 310 315 320
Gln Asn Pro Lys Leu Met Glu Glu Ala Ala Ala Leu Gly Leu Glu Asn
325 330 335
Pro Glu Asp Ile Thr Ala Asn Gln Leu Lys Lys Phe Lys Leu Gln Gly
340 345 350
Thr Pro Arg Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Thr Gly
355 360 365
Phe Asp Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala Glu
370 375 380
Ile Pro Pro Val Phe Asp Ile Ser Arg Asn Phe Met Pro Arg Ala Gly
385 390 395 400
Arg Leu Leu Phe Asn Asp Ile Thr Tyr Ser Leu Pro Asn Pro Ser Tyr
405 410 415
Val Pro Ser Lys Asp Tyr Arg His Trp Glu Gln Gly Gln Val Leu Ala
420 425 430
Ser Asp Leu Lys Thr Gln Tyr Ile Lys Phe Met Val Arg Asp Thr Phe
435 440 445
Ser Leu Thr His Thr Ser Leu Lys Asn Ala Ala Lys Ala Tyr Ser Leu
450 455 460
Thr Val Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe Tyr
465 470 475 480
Met Leu Gly Ser Tyr Gln Gln Asp Ala Asp Gly Phe Pro Asp Leu Lys
485 490 495
Tyr Trp Lys Asp Gln Glu Glu Tyr Cys Phe Asn Lys Asp Leu Trp Lys
500 505 510
Lys Glu Lys Lys Gly Ala Tyr Asp Ile Ile Gln Gln Thr Leu Asp Tyr
515 520 525
Cys Ala Leu Asp Val Gln Val Thr Ala Gln Leu Val Asn Lys Leu Ile
530 535 540
Glu Ser Tyr Gln Ile Phe Ile Lys Asn Ser Val Asn Leu Pro Glu Thr
545 550 555 560
Tyr Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala
565 570 575
Ile Phe Lys Gln Ile Leu Tyr Arg Ala Glu Lys Pro Asn Ala Pro His
580 585 590
Leu Asn Thr Ile Ile Met Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val
595 600 605
Arg Leu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val
610 615 620
Leu Gln Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser
625 630 635 640
Ala Leu Thr His Pro Phe Pro Ala Gly Ser Pro Leu Asn Pro Tyr Glu
645 650 655
Arg Ala Val Ala Ile Lys Ala Tyr Glu His Lys Met Gln Glu His Lys
660 665 670
Thr Ile Ser Tyr Phe Asp Glu Asp Leu Leu Pro Gly Ile Phe Thr Ile
675 680 685
Asp Ala Asp Pro Pro Ala Glu Glu Phe Leu Asp Val Leu Pro Pro Phe
690 695 700
Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg
705 710 715 720
Gly Glu Val Thr Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly
725 730 735
Trp Lys Val Thr Leu Ile Pro Asp Thr Arg Thr Thr Val Phe Pro Glu
740 745 750
Trp Lys Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Asn Ala Lys
755 760 765
Glu Lys Ala Asp Lys Ser Lys Asn Gln Thr Met Arg Ser Ile Ala Lys
770 775 780
Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn
785 790 795 800
Lys Lys Thr Val Phe Ser Asp Gln Ile Glu Ser Asn Ile Ala Lys Glu
805 810 815
Ile Ala Ser Gly Ala Tyr Val Val Lys Ser Ser Ser Tyr Ile Glu Thr
820 825 830
Asp Asn Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro
835 840 845
Pro Val Asn Phe Asp Val His Arg Leu Ala Pro Pro Ser Tyr Ser Glu
850 855 860
Glu Tyr Pro Thr Glu Asn Pro His Ala Glu Gly Pro Phe Met Gln Asn
865 870 875 880
Phe Asn Met Thr Ser Tyr Arg Tyr Lys Pro Ile Met Phe Ile Asp Ala
885 890 895
Glu Asp Asp Asp Phe Cys Leu His Thr Leu Glu Lys Ser Thr Pro Leu
900 905 910
Ile Thr Asn Asn Arg Tyr Ala Ser Gln Ile Ala Ser Phe Val Leu Ala
915 920 925
Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln Phe Leu Tyr Glu Asn
930 935 940
Asp Ala Gly Ile Pro Leu Glu Lys Arg Ile Leu Lys Ser Val Tyr Gly
945 950 955 960
Asp Thr Asp Ser Leu Phe Thr Thr Met Glu Gly Tyr Arg Leu Met Glu
965 970 975
Glu Lys Gly Lys Arg Arg Leu Lys Lys Asn Gly Gly Asn Leu Val Phe
980 985 990
Asp Pro Asn Asn Pro Glu Leu Thr Trp Leu Val Glu Cys Glu Thr Lys
995 1000 1005
Cys Glu Lys Cys Gly Ala Asp Ala Tyr Ser Ser Glu Ser Val Tyr
1010 1015 1020
Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys Pro Glu
1025 1030 1035
Cys Gln Tyr Val Gly Lys Gly Lys Leu Arg Ala Lys Gly His Ala
1040 1045 1050
Thr Ser Thr Leu Ser Tyr Asp Val Leu Lys Ala Cys Tyr Tyr Ala
1055 1060 1065
Asp Leu Gln Gln Gly Ser Asp Ile Phe Lys Thr Ser Arg Met Ser
1070 1075 1080
Leu Arg Arg Thr Leu Thr Ser Val Gln Thr His Val Gln Pro Phe
1085 1090 1095
Thr Val Thr Glu Thr Thr Leu Thr Arg Lys Leu Arg Pro Trp Lys
1100 1105 1110
Asp Lys Thr Leu His Ala Leu Asp Met Asn Arg Leu Ile Pro Tyr
1115 1120 1125
Ser Arg Lys Tyr Pro Asn Pro Arg Asn Asn Glu Thr Thr Trp Met
1130 1135 1140
Glu Leu Gln Trp Met Thr
1145
<210> 2
<211> 1150
<212> PRT
<213> 犬腺病毒2（Canine adenovirus 2）
<400> 2
Met Ser Leu Val Gln Gly His Gly Thr Ser Gly Leu Phe Thr Glu Pro
1 5 10 15
Pro Asn Pro Ile Asn Gln Gln Glu Ser Ser Gly Pro Ser Leu Pro Ala
20 25 30
Gln Asp Ala Ala Gln Ala Phe Ala Ser Ser Pro Arg Ala Gly Ala Thr
35 40 45
Ser Thr Ile Val Asn Pro Pro Lys Arg Lys Tyr Lys Gly Ala Val Val
50 55 60
Val Gln Arg Ala Thr Leu Ser Ile Ser Ala Val Leu Asp Asn Gly Gln
65 70 75 80
Cys Val Glu Ile Lys Tyr His Ser Asn Leu Ala Ser Ala Leu Thr Asn
85 90 95
Leu Cys Asn Thr Asn Leu Tyr Asp Leu Pro Ala Cys Leu Asn Arg Pro
100 105 110
Ile Thr Ala His Asn Leu Pro Ala Leu Ile Glu Glu Ala Ala Ala Pro
115 120 125
Tyr Ser Leu Ile Cys Tyr Tyr Gln Arg Gly Thr Val Arg Arg Val Glu
130 135 140
Phe Gln Ala Glu Val Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val
145 150 155 160
Lys Gln Gly Lys Val Phe Leu Ile Lys Asp Ile Ser Gln Met Gln Lys
165 170 175
Cys Glu Phe Cys Gly Ser Phe Phe Lys Val Thr His Thr Cys Ala Leu
180 185 190
Arg Arg Arg Asp Phe Tyr Phe His His Val Ala Ala His Ser Ala Asp
195 200 205
Trp Trp Glu Lys Ile Ser Phe Thr Pro Ile Gly Ala Pro Pro Asn Thr
210 215 220
Glu Arg Leu Phe Ile Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly
225 230 235 240
Lys Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu Leu
245 250 255
Gly Asp Asp His Leu Val Asn Val Ala Lys Thr Leu Ala Thr Glu Gln
260 265 270
Asn Trp Glu Ile Trp Asn Gly Lys Glu Gln Asp Thr Leu Tyr Tyr Cys
275 280 285
Ile Thr Pro Glu Lys Arg Ala Ile Gly Val Lys Phe Lys Lys Phe Arg
290 295 300
Asp Thr Leu Gln Gln His Ile Ala Ala Ser Leu Trp Ser His Val Ile
305 310 315 320
Cys Gln Asn Pro Gln Leu Gln Glu Lys Ala Thr Thr Leu Gly Leu Glu
325 330 335
Ser Pro Glu Glu Leu Thr Pro Asp Gln Leu Lys Lys Phe Lys Leu Lys
340 345 350
Gly Asn Pro Arg Phe Ile Glu Val Tyr Ala Val Gly His Asn Ile Thr
355 360 365
Gly Phe Asp Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala
370 375 380
Glu Ile Pro Pro Val Phe Glu Ile Cys Arg Asn Phe Met Pro Arg Ala
385 390 395 400
Gly Arg Leu Leu Phe Asn Asp Ile Thr Tyr Ser Leu Pro Asn Pro Ser
405 410 415
Tyr Val Pro Ala Lys Ser Tyr Glu His Trp Glu Gln Gly Gln Val Leu
420 425 430
Ala Ser Asp Leu Lys Ser Gln Tyr Ile Lys Phe Met Val Arg Asp Thr
435 440 445
Phe Ser Leu Thr His Thr Ser Leu Lys Asn Ala Ala Lys Ala Tyr Ser
450 455 460
Leu Thr Val Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe
465 470 475 480
Tyr Met Leu Gly Ser Tyr Gln Gln Asp Ala Asp Gly Phe Pro Asp Leu
485 490 495
Lys Tyr Trp Lys Asp Gln Glu Glu Tyr Ser Phe Asn Lys Asp Leu Trp
500 505 510
Ile Lys Glu Lys Lys Gly Ala Tyr Asp Ile Ile Gln Gln Thr Leu Asp
515 520 525
Tyr Cys Ala Leu Asp Val Gln Val Thr Ala Gln Leu Val Asn Lys Leu
530 535 540
Ile Glu Ser Tyr Gln Ile Phe Ile Lys Asn Ser Val Asn Leu Pro Glu
545 550 555 560
Thr Ser Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His
565 570 575
Ala Ile Phe Lys Gln Ile Leu Tyr Lys Ala Glu Lys Pro Asn Thr His
580 585 590
His Leu Ser Thr Ile Leu Met Ala Pro Ser Asn Glu Met Tyr Glu Tyr
595 600 605
Val Arg Leu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly
610 615 620
Val Leu Gln Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala
625 630 635 640
Ser Ala Leu Thr His Pro Phe Pro Ala Gly Ser Pro Leu Asn Pro Tyr
645 650 655
Glu Arg Ala Leu Ala Ile Lys Ala Tyr Glu Gln Lys Met Leu Asn His
660 665 670
Lys Thr Ile Ser Tyr Phe Asp Lys Asp Leu Leu Pro Gly Ile Phe Thr
675 680 685
Ile Asp Ala Asp Pro Pro Ala Glu Glu Phe Leu Asp Val Leu Pro Pro
690 695 700
Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu
705 710 715 720
Arg Gly Glu Ile Ala Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg
725 730 735
Gly Trp Lys Val Thr Leu Ile Pro Asp Thr Arg Thr Thr Val Phe Pro
740 745 750
Glu Trp Lys Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Ser Ala
755 760 765
Lys Glu Glu Ala Asp Lys Ser Lys Asn Gln Thr Met Arg Ser Ile Ala
770 775 780
Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp
785 790 795 800
Asn Lys Lys Thr Val Phe Ser Asp Gln Ile Glu Ser Asn Ile Ala Lys
805 810 815
Glu Ile Ala Ser Gly Ala Tyr Val Val Lys Ser Ser Ser Tyr Ile Glu
820 825 830
Thr Asp Asn Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr
835 840 845
Pro Pro Val Asn Ser Asp Val Arg Gln Leu Ala Pro Pro Ser Cys Ser
850 855 860
Glu Glu Asp Pro Thr Lys Asp Pro Leu Ala Glu Ala Pro Phe Met His
865 870 875 880
Asn Phe Ser Met Thr Ser Tyr His Tyr Lys Pro Ile Met Phe Ile Asp
885 890 895
Ala Glu Asp Asp Asp Phe Cys Leu His Thr Leu Glu Lys Ser Thr Pro
900 905 910
Leu Ile Ala Asn Asn Arg Tyr Pro Ser Gln Ile Ala Ser Phe Val Leu
915 920 925
Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln Phe Leu Tyr Glu
930 935 940
Asn Asp Ala Gly Thr Pro Leu Glu Asn Arg Val Leu Lys Ser Val Tyr
945 950 955 960
Gly Asp Thr Asp Ser Leu Phe Thr Thr Met Glu Gly Tyr Lys Leu Met
965 970 975
Glu Glu Lys Gly Lys Lys Arg Leu Lys Lys Asn Gly Gly Lys Leu Val
980 985 990
Phe Asp Pro Ser Asn Pro Glu Leu Thr Trp Leu Val Glu Cys Glu Thr
995 1000 1005
Gln Cys Glu Lys Cys Gly Ser Asp Ala Tyr Ser Ser Glu Ser Val
1010 1015 1020
Tyr Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys Pro
1025 1030 1035
Lys Cys His His Val Gly Lys Gly Lys Leu Arg Ala Lys Gly His
1040 1045 1050
Ala Thr Ser Thr Leu Ser Tyr Asp Val Leu Lys Ala Cys Tyr Tyr
1055 1060 1065
Ala Asp Met Gln Gln Gly Ser Asp Val Phe Lys Thr Ser Arg Met
1070 1075 1080
Ser Leu Arg Arg Thr Leu Thr Ser Val Gln Ala His Val Gln Pro
1085 1090 1095
Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Lys Leu Arg Pro Trp
1100 1105 1110
Lys Asp Lys Thr Leu His Ala Leu Asp Met His Arg Leu Ile Pro
1115 1120 1125
Tyr Ser Arg Lys His Pro Asn Pro Arg Asn Thr Glu Thr Thr Trp
1130 1135 1140
Met Glu Leu Gln Trp Met Thr
1145 1150
<210> 3
<211> 1135
<212> PRT
<213> 蝙蝠腺病毒 PPV1（Bat adenovirus PPV1）
<400> 3
Val Gln Gly Asp Arg Thr Arg Gly Ile Leu Pro Lys Gln Thr Asp Ser
1 5 10 15
Asn Tyr Gln Pro Lys Gly Ser Ser Ala Ser Leu Ser Ala Glu Ile Gln
20 25 30
Ser Gln Thr Thr Pro Gly Thr Pro Arg Pro Ser Thr Ala Ser Ser Leu
35 40 45
Lys Thr Pro Arg Arg Lys Tyr Lys Gly Ala Val Val Ala Gln Arg Ala
50 55 60
Thr Leu Ser Ile Ser Ala Met Leu Asp Asp Gly Gln Pro Ala Glu Ile
65 70 75 80
Lys Phe His Ser Asn Leu Leu Thr Ala Leu Thr Ala Leu Cys Asn Thr
85 90 95
Asn Leu His Asp Leu Pro Glu Cys Phe Leu Ala Pro Ile Thr Ala Pro
100 105 110
Asn Leu Pro Ala Leu Ile Glu Gln Ala Ala Ala Pro Tyr Ser Leu Ile
115 120 125
Cys Tyr Tyr Asn Arg Gly Ser Val Arg Arg Val Gln Phe Gln Ala Glu
130 135 140
Ser Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val Lys His Asn Lys
145 150 155 160
Val Phe Leu Ile Lys Asp Ile Ser Pro Val Asn Lys Cys Glu Phe Cys
165 170 175
Gly Ser Phe Phe Lys Val Thr His Thr Cys Ser Leu Arg Arg Arg Asp
180 185 190
Phe Tyr Tyr His His Val Ala Ala His Ser Ser Asp Trp Trp Glu Lys
195 200 205
Ile Ala Phe Ala Pro Ile Gly Ser Pro Ala Glu Thr Glu Arg Leu Phe
210 215 220
Ile Val Tyr Asp Ile Glu Thr Tyr Thr Trp His Gly Lys Phe Gly Lys
225 230 235 240
Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu His Gly Asp Ala His
245 250 255
Leu Val Ala Ala Ala Thr Ala Leu Ala Arg Glu Leu Gly Trp Asp Arg
260 265 270
Trp Gln Asp Lys Glu Asp Val Phe Cys Ile Val Thr Pro Glu Lys Arg
275 280 285
Val Ile Gly Ile Lys Phe Lys Gln Phe Arg Asp Arg Leu Gln Gln Cys
290 295 300
Leu Ala Asn Ser Leu Trp Ser His Phe Leu Val Ala Asn Pro Gln Ile
305 310 315 320
Gln Glu Glu Ala Thr Asn Arg Gly Leu Ala Cys Pro Glu Asp Leu Phe
325 330 335
Pro Glu Asp Leu Arg Lys Ile Lys Val Lys Gly Val Pro Arg Phe Ile
340 345 350
Glu Val Tyr Ala Val Gly His Asn Ile Thr Gly Phe Asp Glu Ile Leu
355 360 365
Leu Ala Ala Gln Val Val Ser Thr Lys Ala Glu Ile Pro Ser Val Phe
370 375 380
Glu Ile Ser Arg Asn Phe Met Pro Arg Ala Gly Arg Leu Leu Phe Asn
385 390 395 400
Asp Val Thr Tyr Ser Leu Pro Asn Pro Ala Trp Val Pro Thr Lys Thr
405 410 415
Phe Glu His Trp Glu Ala Gly Gln Leu Ser Ala Cys Asp Leu Lys Asn
420 425 430
Gln Phe Leu Lys Phe Met Val Arg Asp Thr Phe Thr Leu Thr His Thr
435 440 445
Ser Leu Arg Asn Ala Ala Lys Ala Tyr Ser Leu Pro Val Ala Lys Gly
450 455 460
Cys Cys Pro Tyr Gln Ala Val Asn Asp Phe Tyr Met Leu Gly Thr Tyr
465 470 475 480
Gln Gln Asp Glu Gln Gly Phe Pro Ala Val Glu Tyr Trp Lys Asp Arg
485 490 495
Glu Glu Tyr Leu Leu Asn Lys Ala Leu Trp Leu Asp Lys Lys Thr Gly
500 505 510
Ala Tyr Asp Ile Val Gln Gln Thr Leu Asp Tyr Cys Ala Leu Asp Val
515 520 525
Gln Val Thr Ala Gln Leu Val Gln Lys Leu Ile Ala Ser Tyr Gln Glu
530 535 540
Phe Ile Ala Thr Ser Val Asn Leu Pro Ala Ala Ser Phe Asn Val Phe
545 550 555 560
Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Lys Gln Ile
565 570 575
Leu Tyr Arg Ala Glu Gln Pro Gly Gln Gly His Phe Asn Thr Ile Leu
580 585 590
Leu Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val Arg Ala Ser Ile Arg
595 600 605
Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Ala Glu Pro Val
610 615 620
Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro
625 630 635 640
Phe Pro Ala Gly Ala Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Met
645 650 655
Arg Ala Tyr Glu Leu Lys Met Gln Gln Cys Pro Gln Ile Ser Tyr Phe
660 665 670
Asp Ala Glu Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp Pro Pro
675 680 685
Glu Asp Ser His Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly
690 695 700
Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Ile Ala Thr
705 710 715 720
Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys Val Thr Leu
725 730 735
Val Pro Asp Ala Arg Ala Thr Val Phe Pro Glu Trp Lys Cys Ile Ala
740 745 750
Arg Glu Tyr Val Gln Leu Asn Ile Asn Ala Lys Glu Lys Ala Asp Lys
755 760 765
Asp Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala
770 775 780
Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Thr Val Phe
785 790 795 800
Ser Asp Gln Ile Glu His Asn Leu Ala Lys Glu Ile Ala Ala Gly Glu
805 810 815
Phe Val Val Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn Leu Cys Ala
820 825 830
Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro Pro Ala Asp Thr Pro
835 840 845
Ser Ser Glu Val Asp Ala Ser Pro Leu Ser Glu Asp Pro Glu Glu Thr
850 855 860
Pro Phe Ile Gly Asn Asp Arg Met Thr Ser Tyr Thr Tyr Lys Pro Ile
865 870 875 880
Thr Phe Leu Asp Ala Glu Asp Asp Ser Phe Cys Leu Gln Thr Leu Glu
885 890 895
Arg Ala Ser Pro Leu Ile Ala Asn Asn Arg Tyr Pro Ser Gln Ile Ala
900 905 910
Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln
915 920 925
Phe Leu Tyr Ala Asp Asp Val Gly Ile Pro Leu Glu Asp Arg Gln Leu
930 935 940
Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Thr Thr Leu Glu Gly
945 950 955 960
Tyr Lys Leu Met Glu Thr Lys Gly Lys His Arg Leu Lys Lys Asn Gly
965 970 975
Gly Lys Leu Val Phe Asp Pro Ser Asn Pro Glu Leu Thr Trp Leu Val
980 985 990
Glu Cys Glu Thr Gln Cys Glu Lys Cys Gly Ser Asp Ala Tyr Ser Ser
995 1000 1005
Glu Ser Val Tyr Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr
1010 1015 1020
Thr Cys Val Ser Cys Gly His Val Gly Lys Gly Lys Leu Arg Ala
1025 1030 1035
Lys Gly His Ala Thr Ser Ser Leu Ser Tyr Asp Val Leu Lys Ala
1040 1045 1050
Cys Tyr Leu Ala Asp Met Gln His Gly Ser Asp Val Phe His Thr
1055 1060 1065
Ser Arg Met Ser Leu Arg Arg Thr Leu Thr Ser Val Gln Ser His
1070 1075 1080
Val Gln Pro Phe Thr Val Thr Glu Thr Thr Leu Lys Arg Arg Leu
1085 1090 1095
Arg Pro Trp Lys Asp Lys Thr Leu His Pro Leu Asp Ala Asn Arg
1100 1105 1110
Leu Val Pro Tyr Ser Arg Arg Phe Pro Asn Pro Arg Asn Thr Glu
1115 1120 1125
Thr Thr Trp Met Glu Trp Gln
1130 1135
<210> 4
<211> 1142
<212> PRT
<213> 蝙蝠腺病毒 TJM（Bat adenovirus TJM）
<400> 4
Met Ala Leu Val Gln Asn Asp Gly Ala Arg Arg Leu Phe Pro Glu Gln
1 5 10 15
Pro Asn Ser Asp His Gln Pro Pro Gly His Ser Pro Gly Glu Pro Ala
20 25 30
Gln Ile Pro Ala Pro Ser Pro Ala Gly Ala Pro Leu Pro Gly Ala Ala
35 40 45
Ala Pro Val Lys Pro Gln Arg Arg Gln Tyr Lys Gly Ala Val Val Thr
50 55 60
Gln Arg Ala Thr Leu Ser Val Ser Ala Val Leu Asp Asp Gly Gln Phe
65 70 75 80
Val Glu Ile Lys Tyr His Ala Asp Trp Lys Ala Ala Leu Ala Ser Leu
85 90 95
Cys His Ala Asn Leu Cys Glu Val Pro Ala Cys Phe Glu Asn Pro Leu
100 105 110
Thr Pro Tyr Ser Leu Leu Thr Leu Leu Glu Gln Ala Ala Ala Ala His
115 120 125
Ser Leu Ile Cys Tyr Tyr Gln Arg Gly Lys Val Arg Arg Val Gln Met
130 135 140
Gln Ala Ala Gln Pro Leu Leu His Phe Pro Leu Gln Phe Leu Val Lys
145 150 155 160
Gln Ala Lys Phe Thr Ser Leu Lys Thr Leu Pro Pro Pro Thr Ser Ala
165 170 175
Ser Ser Val Val Leu Ser Thr Arg Ser Pro Thr Pro Ala Pro Ser Gly
180 185 190
Ala Glu Thr Phe Thr Ser Thr Thr Leu Pro Pro Thr Pro Pro Thr Gly
195 200 205
Gly Lys Arg Gln Pro Ser Pro Leu Trp Asp Leu Pro Arg Lys Pro Lys
210 215 220
Gly Cys Leu Leu Ser Met Thr Ser Arg Pro Thr Pro Gly Thr Gly Ala
225 230 235 240
Leu Ala Ser Asn Trp Tyr Pro Ser Cys Gln Ser Ser Ser Trp Trp Ala
245 250 255
Arg Pro Pro Trp Trp Pro Arg Pro Gly Ser Trp Pro Arg Pro Arg Asp
260 265 270
Gly Thr Pro Gly Thr Leu Arg Glu Met Ser Phe Thr Ala Ser Pro Leu
275 280 285
Arg Lys Lys Pro Ser Val Ser Ser Leu Arg Ser Ser Gly Thr Arg Cys
290 295 300
Ser Ser Cys Trp Pro Pro Ser Ser Gly Ser His Phe Leu Ser Gln Asn
305 310 315 320
Pro Asp Leu Glu Ala Lys Thr Arg Glu Leu Gly Leu Pro Asn Ser Glu
325 330 335
Asp Ile Ser Tyr Ala Ala Leu Lys Lys Leu Lys Leu Gln Gly Ala Pro
340 345 350
Arg Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Thr Gly Phe Asp
355 360 365
Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala Glu Ile Pro
370 375 380
Pro Ala Phe Gln Ile Ser Arg Asn Phe Met Pro Arg Ala Gly Arg Leu
385 390 395 400
Leu Phe Asn Asp Val Thr Tyr Ala Leu Pro Asn Pro Ala Tyr Phe Pro
405 410 415
Arg Lys Asp Tyr Thr Asp Trp Glu Lys Gly Gln Leu Leu Ala Cys Asp
420 425 430
Leu Arg Asn Gln Phe Ile Lys Phe Met Val Arg Asp Thr Phe Thr Leu
435 440 445
Thr His Thr Ser Leu Arg Asn Ala Ala Lys Ala Tyr Asn Leu Pro Val
450 455 460
Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe Tyr Met Leu
465 470 475 480
Gly Thr Tyr Arg Arg Asp Ala Asp Gly Phe Pro Ala Glu Asp Tyr Trp
485 490 495
Lys Asp Ala Glu Glu Tyr Arg Phe Asn Lys Gln Leu Trp Arg Glu Glu
500 505 510
Lys Lys Asp Ala Tyr Asp Ile Ile Gln Ser Thr Leu Asp Tyr Cys Ala
515 520 525
Gln Asp Val Lys Val Thr Thr Gln Leu Val Leu Lys Leu Thr Glu Ala
530 535 540
Tyr Gln Ala Phe Val Ala Glu Ser Val Asn Leu Pro Glu Ala Ser Phe
545 550 555 560
Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Leu Phe
565 570 575
Lys Gln Ile Leu Phe Arg Ala Glu Lys Pro Asn Gln Ser His Leu Gly
580 585 590
Thr Thr Leu Leu Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val Arg Ala
595 600 605
Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Phe Ile Gly Leu Leu Asp
610 615 620
Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu
625 630 635 640
Thr His Pro Phe Pro Ala Gly Pro Pro Leu Asn Pro Phe Glu Arg Ala
645 650 655
Leu Ala Val Arg Arg Tyr Glu Leu Lys Met Gln Thr Glu Ala Gln Ile
660 665 670
Ser Tyr Phe Asp Pro Glu Leu Leu Pro Ala Ile Leu Thr Ile Asp Ala
675 680 685
Asp Pro Pro Ala Asp Glu Phe Leu Asp Val Leu Pro Pro Phe Cys Ser
690 695 700
Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu
705 710 715 720
Val Ala Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys
725 730 735
Val Arg Phe Val Pro Asp Ala Arg Ala Thr Val Phe Pro Glu Trp Lys
740 745 750
Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Gln Ala Lys Glu Gln
755 760 765
Ala Asp Lys Asn Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu
770 775 780
Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys
785 790 795 800
Thr Val Phe Ser Asp Gln Ile Asp Ala Glu Thr Ala His Asp Ile Ser
805 810 815
Thr Gly Ala Phe Val Val Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn
820 825 830
Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro Pro Asp
835 840 845
Pro Ser Val Ala Leu Thr His Thr Ala Val Ala Asn Asp Gly Asp Pro
850 855 860
His Pro Glu Thr Pro Phe Met Ser Pro Thr Ser Val Thr Ser Tyr Thr
865 870 875 880
Tyr Lys Pro Ile Thr Phe Leu Asp Ala Glu Asp Asp Asp Phe Cys Leu
885 890 895
His Thr Leu Glu Lys Ser Thr Pro Leu Ile Ala Asn Asn Arg Tyr Pro
900 905 910
Ser Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser
915 920 925
Glu Trp Ala Gln Phe Leu Tyr Ala Asp Asp Ala Gly Ile Pro Leu Glu
930 935 940
Lys Arg Asn Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Thr
945 950 955 960
Thr Arg Glu Gly Tyr Arg Leu Met Glu Glu Lys Gly Lys Lys Arg Leu
965 970 975
Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Asp His Pro Glu Leu
980 985 990
Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys Gly Gly Asp
995 1000 1005
Ala Tyr Ser Thr Glu Ser Val Tyr Leu Ala Pro Lys Leu Tyr Ala
1010 1015 1020
Leu Lys Asn Thr Val Cys Thr Arg Cys Gly His Val Gly Lys Gly
1025 1030 1035
Lys Leu Arg Ala Lys Gly His Ala Thr Ser Glu Leu Ser Tyr Asp
1040 1045 1050
Thr Leu Lys Ala Cys Tyr Leu Ala Asp Leu Gln Gln Gly Ser Asp
1055 1060 1065
Val Phe Gln Thr Ser Arg Thr Ser Leu Arg Arg Thr Leu Ala Ser
1070 1075 1080
Val Gln Ala His Val Gln Pro Phe Thr Val Thr Glu Thr Thr Leu
1085 1090 1095
Thr Arg Lys Leu Arg Pro Trp Lys Asp Lys Thr Leu His Glu Val
1100 1105 1110
Asp Ser His Arg Leu Ile Pro Tyr Ser Arg Arg Phe Pro Asn Pro
1115 1120 1125
Arg Asn Thr Glu Thr Thr Trp Met Glu Leu Pro Trp Thr Ser
1130 1135 1140
<210> 5
<211> 1112
<212> PRT
<213> 土耳其腺病毒3（Turkey adenovirus 3）
<400> 5
Met Ser Lys Tyr Ile Tyr Thr Thr Gln Asn Glu Ile Pro Tyr Arg Leu
1 5 10 15
Gln Ile Cys Lys Lys Asp Ile Lys Ala Thr Ile Ile Glu Ile Ala Trp
20 25 30
Thr Tyr Asn Leu Phe Asn Cys Lys Lys Leu Ala Lys Lys Val Lys Asp
35 40 45
Ala Gln Ser Tyr Ile Leu Ile Cys Ser Lys Tyr Lys Pro Thr Asn Ser
50 55 60
Asp Ile Glu Asn Val Lys Asn Leu Pro Val Lys Ser Ile Thr Ile Trp
65 70 75 80
Lys Lys Leu Thr Gly Cys Val Met Ile Gln Asn Glu Phe Lys Thr Ser
85 90 95
His Glu Tyr Ile Glu Leu Asp Phe Ile Tyr Asp Lys Ser Lys Leu Cys
100 105 110
Trp Ile Lys Ser Trp Thr Gln Gln Gln Lys Cys Ser Ser Cys Gly Arg
115 120 125
Ile Tyr Ser Ala Ile His Thr Cys Asn Asp Leu Arg Ser Thr Tyr Tyr
130 135 140
Tyr Asn Ser Val Asp Asn Asp Thr Arg Lys Phe Trp Glu Thr Ile Pro
145 150 155 160
Phe Gln Pro Ile Gly Glu Asn Glu Asn Thr Lys Lys Leu Phe Leu Ile
165 170 175
Tyr Asp Ile Glu Thr Phe Thr Leu Ala Glu Thr Ser Gly Val Leu Leu
180 185 190
Asn Pro Leu Leu Leu Cys Phe Ser Ile Phe Gly Asp Asp Cys Leu Ile
195 200 205
Asn Ile Cys Lys Thr Glu Ile Ala Lys Ile Lys Ser Ile Gln Thr Lys
210 215 220
Asn Ser Thr Tyr Phe Trp Phe Ser Lys Val Lys Asn Phe Ile Ser Thr
225 230 235 240
Glu Phe Arg Lys Leu Arg Asn Asn Ile Leu Phe Ala Leu Thr Asp Tyr
245 250 255
Phe Thr Lys Leu Ile Leu Thr Pro Glu Asn Arg Glu Ile Leu Glu Asp
260 265 270
Phe Ala Gln Thr Gln Asn Leu Glu Ser Ile Thr Asn Ile Asn Leu Ser
275 280 285
Glu His Thr Asn Leu Ile Met Ser Leu Lys Val Lys Pro Ile Phe Ile
290 295 300
Glu Phe Tyr Ile Ile Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu
305 310 315 320
Leu Ala Thr Gln Ile Leu Gln Asp Glu Asn Leu Asp Ile Thr Pro Leu
325 330 335
Phe Thr Val Glu Arg Asn Phe Met Pro Arg Gln Gly Arg Ile Leu Phe
340 345 350
Asn Asp Ile Thr Ile Lys Phe Pro Asn Pro Asp Tyr Tyr Val Ala Lys
355 360 365
Glu Glu Lys Lys Asn Asn Lys Ser Glu Ile Leu Ser Gln Ile Lys Glu
370 375 380
Gly Ile Pro His Pro Glu Ser Ile Lys Asn Leu Tyr Ile Lys Ser Met
385 390 395 400
Val Arg Asp Thr Phe Gln Ile Thr His Thr Ser Leu Lys Glu Ala Ala
405 410 415
Lys Ala Tyr Asn Leu Lys Ile His Lys Gly Cys Cys Pro Phe Lys Ala
420 425 430
Ile Asn Glu Tyr Met Ser Thr Asn Ser Leu Ser Thr Asp Ser Asp Ser
435 440 445
Phe Pro Ser Glu Lys Tyr Trp Ser Ser Lys Glu Glu Tyr Asn Glu Gln
450 455 460
Lys Glu Ile Trp Leu Glu Lys Lys Glu Val Lys Tyr Asp Ile Val Lys
465 470 475 480
Glu Leu Ile Asp Tyr Cys Ile Lys Asp Val Lys Ile Thr Glu Glu Leu
485 490 495
Thr Lys Thr Leu Leu Asn Thr Phe Asp Thr Phe Ile Lys Glu Glu Leu
500 505 510
Asn Leu Lys Cys Asn Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser Ser
515 520 525
Asn Ser His Ala Ile Phe Arg Gln Leu His Phe Lys Gln Asn Gly Thr
530 535 540
Lys Ala Ser Thr Leu Pro Asp Ile Val Ala Pro Ser Asp Glu Met Tyr
545 550 555 560
Ser Phe Ile Arg Gln Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr His
565 570 575
Leu Gly Ile Phe Lys Glu Lys Ile Phe Val Tyr Asp Ile Cys Gly Met
580 585 590
Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Phe Pro Ile Gly
595 600 605
Glu Lys Glu Arg Asn Asn Glu Ile Thr Lys Leu Asn Glu Lys Leu Lys
610 615 620
Lys Thr Lys Thr Lys Leu Ser Tyr Phe Thr Asp Ile Lys Pro Met Val
625 630 635 640
Val Met Ile Asp Ala Ile Pro Pro Pro Pro Glu His Leu Asp Pro Leu
645 650 655
Pro Pro Leu Cys Ser Arg Gln Ser Gly Lys Leu Cys Trp Thr Asn Glu
660 665 670
Ile Leu Lys Asn Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His
675 680 685
Asn Arg Gly Trp Lys Val Asn Ile Ile Pro His Lys Leu Asn Thr Val
690 695 700
Phe Pro Thr Trp Asn Thr Cys Cys Leu Glu Tyr Val Thr Lys Asn Ile
705 710 715 720
Leu Ala Lys Glu Lys Ala Thr Val Glu Lys Asn Pro Val Lys Arg Ala
725 730 735
Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg
740 745 750
Glu Ser Asn Asp Ile Thr Ile Phe Glu Asn His Ile Gln Glu Asn Pro
755 760 765
Lys Ile Arg Asn Gln Leu Leu Asn Lys Gln Leu Thr Ile Asp Ser Ile
770 775 780
Thr Thr Leu Pro Thr Tyr Asn Leu Pro Tyr Val Ser Ile Glu Asn Leu
785 790 795 800
Thr Phe Thr Leu Lys Asn Arg Thr Asp Ser Ala Glu Arg Asn Leu Glu
805 810 815
Leu Asp Asp Glu Leu Thr Ser Pro Phe Asn Ser Leu Glu Phe Met Asp
820 825 830
Glu Ser Pro Ala Ser Gln Thr Ser Thr Ser Thr Ala His Val Gly Thr
835 840 845
Tyr Lys Pro Phe Asn Ile Leu Asp Val Thr Ser Glu Asn Leu Thr Ile
850 855 860
Tyr Met Leu Lys Ser Thr Asn Leu His Pro Thr Asn Lys Arg Tyr Pro
865 870 875 880
Thr Gln Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser
885 890 895
Glu Trp Arg Glu Ile Leu Tyr Ser Asp Glu Asp Ser Ile Pro Val Gln
900 905 910
Phe Lys Thr Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu
915 920 925
Thr Glu Lys Gly His Gln Asn Met Leu Lys Tyr Gly Gln His Arg Ile
930 935 940
Lys Asn Lys Asn Ser Gln Leu Thr Phe Asp Pro Lys Lys Pro Ser Ile
945 950 955 960
Val Trp Ala Val Glu Cys Glu Thr Trp Cys Asn Leu Cys Asn Ser Pro
965 970 975
Ala Tyr Ser Ser Lys Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu
980 985 990
Lys Glu Ile Thr Cys Thr Thr Cys Lys Asn Ser Lys Thr Gly Lys Leu
995 1000 1005
Arg Ala Lys Gly His Cys Thr Ala Asp Ile Thr Phe Glu Ile Leu
1010 1015 1020
Glu Glu Cys Phe Asn Tyr His Thr Ser Glu Leu Lys Ser Gly Glu
1025 1030 1035
Ile Phe Gln Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Cys Lys
1040 1045 1050
Ser Tyr Gly Lys Phe Ser Pro Phe Ser Val His Glu Ile Gln Leu
1055 1060 1065
Ile Arg Glu Leu Arg Pro Trp Asn Asp Pro Thr Leu Tyr Phe Leu
1070 1075 1080
Lys Thr Asn Thr Leu Ile Pro Tyr Asp Leu Tyr His Pro Asn Pro
1085 1090 1095
Arg Ile Thr Asn Pro Ile Leu Leu Gln Glu Phe Glu Asp Glu
1100 1105 1110
<210> 6
<211> 1112
<212> PRT
<213> 土耳其腺病毒 A（turkey adenovirus A）
<400> 6
Met Ser Lys Tyr Ile Tyr Thr Thr Gln Asn Glu Ile Pro Tyr Arg Leu
1 5 10 15
Gln Ile Cys Lys Lys Asp Ile Lys Ala Thr Ile Ile Glu Ile Ala Trp
20 25 30
Thr Tyr Asn Leu Phe Asn Cys Lys Lys Leu Ala Lys Lys Val Lys Asp
35 40 45
Ala Gln Ser Tyr Ile Leu Ile Cys Ser Lys Tyr Lys Pro Thr Asn Ser
50 55 60
Asp Ile Glu Asn Val Lys Asn Leu Pro Val Lys Ser Ile Thr Ile Trp
65 70 75 80
Lys Lys Leu Thr Gly Cys Val Met Ile Gln Asn Glu Phe Lys Thr Ser
85 90 95
His Glu Tyr Ile Glu Leu Asp Phe Ile Tyr Asp Lys Ser Lys Leu Cys
100 105 110
Trp Ile Lys Ser Trp Thr Gln Gln Gln Lys Cys Ser Ser Cys Gly Arg
115 120 125
Ile Tyr Ser Ala Ile His Thr Cys Asn Asp Leu Arg Ser Thr Tyr Tyr
130 135 140
Tyr Asn Ser Val Asp Asn Asp Thr Arg Lys Phe Trp Glu Thr Ile Pro
145 150 155 160
Phe Gln Pro Ile Gly Glu Asn Glu Asn Thr Lys Lys Leu Phe Leu Ile
165 170 175
Tyr Asp Ile Glu Thr Phe Thr Leu Ala Glu Thr Ser Gly Val Leu Leu
180 185 190
Asn Pro Leu Leu Leu Cys Phe Ser Ile Phe Gly Asp Asp Cys Leu Ile
195 200 205
Asn Ile Cys Lys Thr Glu Ile Ala Lys Ile Lys Ser Ile Gln Thr Lys
210 215 220
Asn Ser Thr Tyr Phe Trp Phe Ser Lys Val Lys Asn Phe Ile Ser Thr
225 230 235 240
Glu Phe Arg Lys Leu Arg Asn Asn Ile Leu Phe Ala Leu Thr Asp Tyr
245 250 255
Phe Thr Lys Leu Ile Leu Thr Pro Glu Asn Arg Glu Ile Leu Glu Asp
260 265 270
Phe Ala Gln Thr Gln Asn Leu Glu Ser Ile Thr Asn Ile Asn Leu Ser
275 280 285
Glu His Thr Asn Leu Ile Met Ser Leu Lys Val Lys Pro Ile Phe Ile
290 295 300
Glu Phe Tyr Ile Ile Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu
305 310 315 320
Leu Ala Thr Gln Ile Leu Gln Asp Glu Asn Leu Asp Ile Thr Pro Leu
325 330 335
Phe Thr Val Glu Arg Asn Phe Met Pro Arg Gln Gly Arg Ile Leu Phe
340 345 350
Asn Asp Ile Thr Ile Lys Phe Pro Asn Pro Asp Tyr Tyr Val Ala Lys
355 360 365
Glu Glu Lys Lys Asn Asn Lys Ser Glu Ile Leu Ser Gln Ile Lys Glu
370 375 380
Gly Ile Pro His Pro Glu Ser Ile Lys Asn Leu Tyr Ile Lys Ser Met
385 390 395 400
Val Arg Asp Thr Phe Gln Ile Thr His Thr Ser Leu Lys Glu Ala Ala
405 410 415
Lys Ala Tyr Asn Leu Lys Ile His Lys Gly Cys Cys Pro Phe Lys Ala
420 425 430
Ile Asn Glu Tyr Met Ser Thr Asn Ser Leu Ser Thr Asp Ser Asp Ser
435 440 445
Phe Pro Ser Glu Lys Tyr Trp Ser Ser Lys Glu Glu Tyr Asn Glu Gln
450 455 460
Lys Glu Ile Trp Leu Glu Lys Lys Glu Val Lys Tyr Asp Ile Val Lys
465 470 475 480
Glu Leu Ile Asp Tyr Cys Ile Lys Asp Val Lys Ile Thr Glu Glu Leu
485 490 495
Thr Lys Thr Leu Leu Asn Thr Phe Asp Thr Phe Ile Lys Glu Glu Leu
500 505 510
Asn Leu Lys Cys Asn Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser Ser
515 520 525
Asn Ser His Ala Ile Phe Arg Gln Leu His Phe Lys Gln Asn Gly Thr
530 535 540
Lys Ala Ser Thr Leu Pro Asp Ile Val Ala Pro Ser Asp Glu Met Tyr
545 550 555 560
Ser Phe Ile Arg Gln Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr His
565 570 575
Leu Gly Ile Phe Lys Glu Lys Ile Phe Val Tyr Asp Ile Cys Gly Met
580 585 590
Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Phe Pro Ile Gly
595 600 605
Glu Lys Glu Arg Asn Asn Glu Ile Thr Lys Leu Asn Glu Lys Leu Lys
610 615 620
Lys Thr Lys Thr Lys Leu Ser Tyr Phe Thr Asp Ile Lys Pro Met Val
625 630 635 640
Val Met Ile Asp Ala Ile Pro Pro Pro Pro Glu His Leu Asp Pro Leu
645 650 655
Pro Pro Leu Cys Ser Arg Gln Ser Gly Lys Leu Cys Trp Thr Asn Glu
660 665 670
Ile Leu Lys Asn Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His
675 680 685
Asn Arg Gly Trp Lys Val Asn Ile Ile Pro His Lys Leu Asn Thr Val
690 695 700
Phe Pro Thr Trp Asn Thr Cys Cys Leu Glu Tyr Val Thr Lys Asn Ile
705 710 715 720
Leu Ala Lys Glu Lys Ala Thr Val Glu Lys Asn Pro Val Lys Arg Ala
725 730 735
Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg
740 745 750
Glu Ser Asn Asp Ile Thr Ile Phe Glu Asn His Ile Gln Glu Asn Pro
755 760 765
Lys Ile Arg Asn Gln Leu Leu Asn Lys Gln Leu Thr Ile Asp Ser Ile
770 775 780
Thr Thr Leu Pro Thr Tyr Asn Leu Pro Tyr Val Ser Ile Glu Asn Leu
785 790 795 800
Thr Phe Thr Leu Lys Asn Arg Thr Asp Ser Ala Glu Arg Asn Leu Glu
805 810 815
Leu Asp Asp Glu Leu Thr Ser Pro Phe Asn Ser Leu Glu Phe Met Asp
820 825 830
Glu Ser Pro Ala Ser Gln Thr Ser Thr Ser Thr Ala His Val Gly Thr
835 840 845
Tyr Lys Pro Phe Asn Ile Leu Asp Val Thr Ser Glu Asn Leu Thr Ile
850 855 860
Tyr Met Leu Lys Ser Thr Asn Leu His Pro Thr Asn Lys Arg Tyr Pro
865 870 875 880
Thr Gln Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser
885 890 895
Glu Trp Arg Glu Ile Leu Tyr Ser Asp Glu Asp Ser Ile Pro Val Gln
900 905 910
Phe Lys Thr Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu
915 920 925
Thr Glu Lys Gly His Gln Asn Met Leu Lys Tyr Gly Gln His Arg Ile
930 935 940
Lys Asn Lys Asn Ser Gln Leu Thr Phe Asp Pro Lys Lys Pro Ser Ile
945 950 955 960
Val Trp Ala Val Glu Cys Glu Thr Trp Cys Asn Leu Cys Asn Ser Pro
965 970 975
Ala Tyr Ser Ser Lys Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu
980 985 990
Lys Glu Ile Thr Cys Thr Thr Cys Lys Asn Ser Lys Thr Gly Lys Leu
995 1000 1005
Arg Ala Lys Gly His Cys Thr Ala Asp Ile Thr Phe Glu Ile Leu
1010 1015 1020
Glu Glu Cys Phe Asn Tyr His Thr Ser Glu Leu Lys Ser Gly Glu
1025 1030 1035
Ile Phe Gln Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Cys Lys
1040 1045 1050
Ser Tyr Gly Lys Phe Ser Pro Phe Ser Val His Glu Ile Gln Leu
1055 1060 1065
Ile Arg Glu Leu Arg Pro Trp Asn Asp Pro Thr Leu Tyr Phe Leu
1070 1075 1080
Lys Thr Asn Thr Leu Ile Pro Tyr Asp Leu Tyr His Pro Asn Pro
1085 1090 1095
Arg Ile Thr Asn Pro Ile Leu Leu Gln Glu Phe Glu Asp Glu
1100 1105 1110
<210> 7
<211> 1108
<212> PRT
<213> 大山雀腺病毒（Great tit adenovirus）
<400> 7
Met Ser Tyr Met Tyr Val Thr Gln Asn Glu Thr Pro Tyr Arg Leu Ser
1 5 10 15
Ile Ser Lys Lys Ser Ile Lys Glu Thr Leu Leu Glu Ile Cys Trp Asn
20 25 30
Phe Asn Phe Phe His Cys Lys Lys Ile Cys Lys Lys Leu Lys Gln Cys
35 40 45
Glu Ser Tyr Ile Leu Val Cys Cys Lys Phe Lys Glu Gln Asn Thr Ala
50 55 60
Ile Glu Asn Ile Lys Gln Leu Pro Ala Gln Lys Ile Thr Ile Trp Lys
65 70 75 80
Lys Leu Thr Gly Cys Ile Val Ile Gln Gln Glu Ile Thr Asn Ser Thr
85 90 95
Ala Ser Ser Ile Gln Leu Asp Phe Val Gln Thr Lys Asp Gly Leu Lys
100 105 110
Trp Ile Lys Thr Trp Thr Lys Gln Gln Lys Cys Thr Ser Cys Gly Arg
115 120 125
Ile Tyr Val Thr Ser His Thr Cys Asp Tyr Asn Arg Ser Ser Phe Tyr
130 135 140
Tyr Asn Gln Ile Ala Ser Ser Lys Lys Tyr Trp Glu Ser Ile Gln Phe
145 150 155 160
Gln Pro Ile Gly Glu Thr Glu Asn Thr Phe Lys Leu Phe Leu Val Tyr
165 170 175
Asp Ile Glu Thr Tyr Thr Leu Ala Glu Ser Glu Gly Ile Asn Leu Gln
180 185 190
Pro Cys Leu Leu Cys Phe Thr Ile Phe Gly Glu Gln Glu Leu Thr Lys
195 200 205
Ile Ala Met Glu Glu Ile Asn Arg Asp Arg Thr Ile Thr His Ser Asn
210 215 220
Asp Asn Ile Phe Tyr Trp His Ser Lys Thr Lys Asn Phe Ile Ser Gln
225 230 235 240
Gln Phe Arg Leu Leu Arg Glu Asn Ile Leu Asn Arg Met Ile Gln Val
245 250 255
Leu Thr Thr His Ile Leu Ser Lys Glu Asn Lys Glu Val Leu Asp Asp
260 265 270
Phe Ile Lys Leu Lys Lys Leu Gln Thr Tyr Lys Asp Ile Asp Ile Ser
275 280 285
Lys Glu Lys Asn Leu Leu Leu Ser Leu Thr Ile Lys Pro Ile Phe Leu
290 295 300
Glu Phe Tyr Val Val Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu
305 310 315 320
Leu Ala Thr Gln Ile Leu Gln Pro Asn Lys Phe Gln Tyr Glu Pro Phe
325 330 335
Leu Thr Ile Ser Arg Asn Phe Met Pro Arg Gln Gly Lys Ile Leu Phe
340 345 350
Asn Asp Ile Thr Ile Thr Phe Pro Asn Pro Glu Tyr His Ile Ala Asp
355 360 365
Glu Gly Lys Glu Asn Lys Thr Ala Glu Ile Ile Ala Asp Ala Arg Glu
370 375 380
Gly Lys Pro Asn Val Lys Asn Ile Lys His Leu Tyr Val Lys Ser Met
385 390 395 400
Val Arg Asp Thr Phe Gln Ile Thr His Ser Ser Leu Lys Thr Ala Ala
405 410 415
Glu Ala Tyr Asn Leu Pro Thr Ser Lys Gly Cys Cys Pro Phe Lys Ala
420 425 430
Ile Asn Asp Phe Tyr Ser Leu Gly Ser Tyr Arg Gly Glu Ser Glu Thr
435 440 445
Asn Phe Pro Val Val Thr Tyr Trp Ser Cys Glu Asp Glu Tyr Lys Glu
450 455 460
Gln Leu Glu Ile Trp Lys Gln Lys Gln Glu Lys Asn Tyr Asp Ile Val
465 470 475 480
Lys Glu Leu Ile Glu Tyr Cys Cys Arg Asp Val Leu Val Thr Val Ser
485 490 495
Leu Thr Lys Cys Leu Leu Glu Thr Phe Asn Ser Phe Val Thr His Glu
500 505 510
Phe Asn Leu Asn Cys Thr Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser
515 520 525
Ser Asn Ser His Ala Ile Phe Arg Gln Ile His Tyr Lys Glu Tyr Gly
530 535 540
Asn Lys Leu Asn Gln Leu Pro Asp Ile Tyr Ala Pro Ser Glu Glu Met
545 550 555 560
Tyr Glu Phe Ile Arg Lys Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr
565 570 575
Phe Leu Gly Arg Phe Ala Glu Lys Leu Tyr Val Tyr Asp Ile Cys Gly
580 585 590
Met Tyr Ala Ser Ala Leu Thr His Pro Leu Pro Tyr Gly Thr Pro Val
595 600 605
Gly Lys Glu Glu Arg Asp His Glu Ile Lys Lys Phe Asn Gln Leu Leu
610 615 620
Ser Ser Lys Asp Glu Ile Ser Tyr Phe Ala Asp Ile Lys Pro Met Ile
625 630 635 640
Val Cys Ile Asn Ala Phe Pro Pro Pro Pro Glu Leu Leu Asp Pro Leu
645 650 655
Pro Pro Leu Cys Ser Lys Ala Ser Gly Lys Leu Cys Trp Thr Asn Glu
660 665 670
Pro Leu His Lys Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His
675 680 685
Asn Arg Arg Trp Ser Val Ser Ile Leu Gln His Pro Leu Asn Thr Val
690 695 700
Phe Ser Ser Trp Lys Thr Cys Cys Ser Asn Tyr Val Lys Ala Asn Ile
705 710 715 720
Gln Ala Lys Glu Lys Ala Ser Lys Glu Lys Asn Pro Val Lys Arg Ala
725 730 735
Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys
740 745 750
Glu Asp Asn Asp Met Val Ile Phe Glu Gln Ser Leu Thr Asp Lys Ile
755 760 765
Lys His Gln Ile Ser Gln Asn Glu Leu Gln Ile Thr Asn Ile Thr Ser
770 775 780
Ile Pro Thr Glu Gln Leu Pro Ser Thr Cys Tyr Thr Asn Ile Gln Tyr
785 790 795 800
Phe Leu Lys Ser Lys Leu Pro Asp His Arg Ala Asn Gln Gln Ala Asp
805 810 815
Asp Glu Leu Thr Ser Pro Phe Glu Ala Val Pro Glu Glu Gln Pro Glu
820 825 830
Pro Ser Phe Cys Ser Thr Gln Thr His Met Thr Thr Tyr Lys Pro Phe
835 840 845
Asn Ile Leu Asp Val Thr Ser Asp Asn Leu Thr Ile Tyr Met Leu Lys
850 855 860
Ser Thr Lys Pro His Pro Thr Asn Lys Arg Tyr Pro Thr Gln Leu Ala
865 870 875 880
Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Ile Ser Glu Trp Ala Glu
885 890 895
Ile Leu Tyr His Asp Glu Asn Asn Ile Pro Ile Glu Asn Lys Ser Leu
900 905 910
Lys Ala Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Ala Gly
915 920 925
His Arg Leu Met Leu Ser Lys Gly Asn Tyr Arg Leu Lys Ser Asp Lys
930 935 940
Thr Pro Leu Ile Phe Asn Pro Glu Ala Pro Lys Leu Thr Trp Ala Val
945 950 955 960
Glu Cys Glu Thr Glu Cys Asn Val Cys Lys Lys Pro Gly Phe Cys Pro
965 970 975
Asp Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Lys Ile Phe
980 985 990
Cys Pro Ser Cys Asn Thr Glu Phe Gly Gly Lys Leu Arg Ala Lys Gly
995 1000 1005
His Ala Thr Thr His Leu Thr Phe Glu Ile Leu Leu Glu Cys Phe
1010 1015 1020
Asn Cys His Lys Thr Cys Ser Gly Pro Ala Arg Lys Phe Thr Thr
1025 1030 1035
Glu Arg Arg Ala Leu Lys Arg Thr Ile His Lys Pro Tyr Gly Gln
1040 1045 1050
Phe Ser Pro Phe Thr Ile His Glu Ile Asn Leu Ile Arg Glu Leu
1055 1060 1065
Arg Pro Trp His Asp Pro Thr Leu Val Phe Ile Thr Asp Lys Val
1070 1075 1080
Leu Ile Pro Tyr Asp Leu Gln His Arg Asn Pro Arg Val Thr Ala
1085 1090 1095
Pro Ile Leu Ile Glu Glu Phe Glu Asp Glu
1100 1105
<210> 8
<211> 1108
<212> PRT
<213> 蛙腺病毒1（frog adenovirus 1）
<400> 8
Met Ser Ala Phe Gly Ser Ile Glu Asn Asp His Phe Arg Leu Lys Leu
1 5 10 15
Asn Ser Lys Pro Ala Lys Leu Ala Ile Leu Asp Ile Cys Trp Gln Phe
20 25 30
Asn Leu Phe Asn Cys Lys Lys Phe Lys His Lys Lys His Ile Ala Ser
35 40 45
Leu Ile Tyr Ser Gln Cys Ser Tyr Asn Ser Asn Lys Ser Leu Tyr Glu
50 55 60
Leu Cys Lys Thr Leu Pro Ile Lys Thr Leu Gln Leu Trp Lys Ile Gln
65 70 75 80
Lys Gly Ser Ile Ile Arg Thr Gln Lys Leu Asp Leu Asp Gln Gly Glu
85 90 95
Ile Ile Ile Asp Leu Leu Ser Pro Lys His Leu Trp Ile Val Glu Trp
100 105 110
Phe Glu Gln Asn Lys Cys Lys Asn Cys Gly Arg Phe Phe Ser Tyr Asn
115 120 125
His Val Cys Asn Thr Asn Arg Ala Ser Tyr Tyr Tyr His Lys Ile Ala
130 135 140
Asn Thr Lys Thr Gln Trp Glu Thr Ile Asn Phe Ser Pro Ile Gly Glu
145 150 155 160
Pro Lys Gly Thr Lys Lys Leu Phe Leu Val Tyr Asp Ile Glu Thr Tyr
165 170 175
Thr Lys Ala Cys Pro Val Gly Tyr Lys Leu Cys Pro Val Leu Leu Cys
180 185 190
Phe Thr Ile Phe Gly Asp Glu Thr Leu Asn Lys Glu Val His Glu Leu
195 200 205
Ile Ser Ser Asn Ser Asn Ile Leu Glu Leu Asn Asn Leu Gly Glu Cys
210 215 220
Phe Tyr Trp Leu Ser Lys Glu Thr Asn Tyr Ile Ser Ser Lys Phe Arg
225 230 235 240
Lys Thr Arg Leu Leu Ile Gln Asn Phe Leu Ile Glu Lys Met Ile Lys
245 250 255
Asn Phe Leu Thr Glu Glu Asn Lys Glu Ile Leu Thr Asp Tyr Ala Lys
260 265 270
Ala His Asn Tyr Glu Ser Ile Tyr Glu Ile Asp Leu Leu Lys Asp Lys
275 280 285
Asn Leu Ile Leu Thr Leu Gln Ala Pro Phe Ile Asn Leu Glu Phe Tyr
290 295 300
Val Ile Gly His Asn Ile Ser Ser Phe Asp Glu Ile Leu Leu Ala His
305 310 315 320
Gln Ile Leu Gln Lys Asp Thr Thr Thr Ile Pro Gln Pro Phe Ile Gln
325 330 335
Ile Lys Arg Asn Phe Leu Pro Arg Gln Gly Lys Ile Leu Phe Asn Asp
340 345 350
Ile Thr Phe Ser Leu Pro Tyr Pro Glu Tyr Tyr Val His Glu Glu Glu
355 360 365
Asn Thr Leu Thr Lys Lys Glu Ala Ile Glu Ile Glu Lys Thr Gly Glu
370 375 380
Pro Ser Leu Phe Arg Thr Lys Glu Ile Cys Val Lys Thr Met Val Arg
385 390 395 400
Asp Thr Tyr Gln Leu Thr His Cys Ser Leu Arg Leu Ala Ala Glu Ala
405 410 415
Tyr Gly Leu Lys Thr Thr Lys Gly Asn Cys Pro Phe Lys Ala Val Thr
420 425 430
Glu Phe Tyr Ser Val Asn Ser Phe Asp Lys Asp Lys Phe Gly Phe Pro
435 440 445
Ala Pro Lys Tyr Trp Thr Asp Asn Glu Glu Tyr Met Thr Gln Leu Lys
450 455 460
Ile Trp Gln Gln Asn Asp Glu Pro Tyr Asp Leu Gln Lys Glu Leu Ile
465 470 475 480
Lys Tyr Cys Ala Gln Asp Val Asn Val Thr Lys Asn Leu Thr Ile Ser
485 490 495
Ile Leu Asn Ser Tyr Asn Glu Phe Ile Lys Glu Asn Phe Lys Leu Thr
500 505 510
Cys Asn Tyr Asn Val Phe Lys Arg Pro Thr Ile Pro Ser Asn Ser Gln
515 520 525
Ala Ile Phe Lys Gln Leu Leu Tyr Lys Lys His Gly Lys Lys Phe Gly
530 535 540
Lys Met Pro Asp Ile Met Ala Pro Ser Ala Glu Met Tyr Glu Phe Val
545 550 555 560
Arg Glu Ser Val Arg Gly Gly Arg Cys Tyr Pro Ser Leu Leu Gly Glu
565 570 575
Ile Lys Glu Pro Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser
580 585 590
Ala Leu Thr His Pro Met Pro Phe Gly Val Pro Leu Ser Gln Lys Glu
595 600 605
Lys Asn Gln Glu Ile His Ile Leu Gln Ser Lys Leu Gln Asn Glu Lys
610 615 620
Thr Leu Asn Tyr Phe Asp Pro Glu Ile Lys Pro Met Ile Ile Ser Ile
625 630 635 640
Ser Ala Phe Pro Pro Pro Val Glu Tyr Leu Thr Asn Ile Pro Pro Ile
645 650 655
Cys Ser Arg Lys Ser Gly Arg Leu Cys Trp Thr Asn Glu Ala Leu Tyr
660 665 670
Asp Glu Thr Val Thr Ile Val Asp Val Ile Thr Leu His Asn Cys Gly
675 680 685
Trp Lys Val Lys Ile Glu Asp His Pro Leu Asn Thr Val Phe Pro Asn
690 695 700
Trp Asn Thr Cys Cys Lys Glu Tyr Val Glu Val Asn Ile Ala Ala Lys
705 710 715 720
Glu Lys Ala Asp Lys Asp Lys Asn Gln Ile Met Arg Ser Ile Ser Lys
725 730 735
Leu Leu Ser Asn Ser Leu Tyr Gly Ser Phe Ala Thr Lys Glu Asp Asn
740 745 750
Ser Met Ile Val Phe Glu His Met Leu Lys Ser Asn His Ile Lys Thr
755 760 765
Lys Leu Glu Gln Asn Glu Ile Lys Ile Asp Ala Val Phe Gly Ile Pro
770 775 780
Thr Asn Gly Ile Glu His Thr Thr Ile Asp Asn Lys Leu Phe Tyr Leu
785 790 795 800
Ser Asn Thr Asn Thr Leu Asn Asp Ser Asn Ala Pro Pro Ile Asp Asp
805 810 815
Glu Leu Leu Thr Pro Phe Ser Glu Glu Ala Tyr Ala Glu Glu Glu Val
820 825 830
Glu Gln Leu Ala Pro Glu Asn Ser Asn Cys His Val Arg Thr Tyr Gln
835 840 845
Pro Phe Thr Leu Ile Asp Val Asp Thr Glu Asp Leu Thr Leu Tyr Ser
850 855 860
Leu Lys Ser Asn Lys Lys Phe Thr Glu Asn Lys Arg Tyr Pro Thr Gln
865 870 875 880
Leu Ala Ser Phe Val Leu Ser Trp Thr Arg Ala Phe Met Ala Asp Trp
885 890 895
Asn Ala Ile Leu Tyr Glu Lys Asp Ser Lys Ser Ile Leu Val Lys Glu
900 905 910
Leu Asn Ala Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Lys
915 920 925
Gly His Lys Arg Met Ile Asp His Gly Gln His Arg Leu Lys Glu Asn
930 935 940
Val Lys Ser Leu Val Phe Gln Glu Cys Cys Pro Asp Ile Thr Trp Ala
945 950 955 960
Val Glu Cys Glu Thr Lys Cys Pro Asn Cys Lys Ser Ser Ala Phe Ser
965 970 975
Asn Arg Thr Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Arg Ile
980 985 990
Val Cys Asn Ser Cys Asn Thr Glu Thr Glu Gly Lys Leu Arg Ala Lys
995 1000 1005
Gly His Ala Lys Asn Asp Met Thr Phe Glu Leu Leu Cys Thr Cys
1010 1015 1020
Phe Glu Tyr His Lys Asn Cys His Thr Lys Gly Lys Arg Phe Ser
1025 1030 1035
Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Tyr Lys Pro Tyr Gly
1040 1045 1050
Lys Phe Glu Pro Phe Thr Ile His Gln Val Arg Leu Ile Arg Glu
1055 1060 1065
Leu Arg Pro Trp His Asp Pro Thr Met Leu Glu Arg Asp Asp Gly
1070 1075 1080
Phe Leu Ile Pro Tyr Tyr Val Gly His Pro Asn Pro Arg Asp Lys
1085 1090 1095
Arg Val Lys Tyr Leu Glu Asp Ile Asp Gly
1100 1105
<210> 9
<211> 1255
<212> PRT
<213> 禽腺病毒1（fowl adenovirus 1）
<400> 9
Met Glu Ala Asp Ala Gly Pro Pro Leu Thr Asp Ser Val Leu Gly Pro
1 5 10 15
Asp Ser His Val Ile Arg Thr Ile Ser Ala Lys Arg Leu Glu Glu Thr
20 25 30
Arg Lys Tyr Phe Lys Ser Phe Arg Gly Asn Pro Leu Arg Thr Asn Val
35 40 45
Tyr Tyr Ile Glu Glu Gln Pro Phe Arg Phe Gln Pro Thr Val Phe Pro
50 55 60
Ile Gly Leu Lys Lys Phe Leu Arg Thr His Arg Phe Leu Leu Ser Lys
65 70 75 80
Arg Ala Arg Gly Tyr Asp Arg Ile Asp Tyr Leu His Tyr Ala Arg Asp
85 90 95
Pro Glu Arg Ser Leu Pro Asp Phe Lys Pro Ala Gln Val Thr Val Ile
100 105 110
Asp Phe Lys Gly Lys Thr Ala Arg Leu Arg Thr Val His Ile Ser Glu
115 120 125
His Pro Ala Leu Pro Pro Met Leu Ile Ala Lys Asn Val Thr Gly Glu
130 135 140
Trp Val Trp Ile Thr Ser Arg Thr Pro Val Gln Gln Cys Pro Thr Cys
145 150 155 160
Gly Arg His Trp Val Arg Arg His Ser Cys Asn Glu Arg Arg Ser Ala
165 170 175
Phe Tyr Tyr His Ala Val Gln Gly Ser Gly Ser Asp Leu Trp Gln His
180 185 190
Val His Phe Ser Cys Pro Ala Gln His Pro His Ile Arg Gln Leu Tyr
195 200 205
Ile Thr Tyr Asp Ile Glu Thr Tyr Thr Val Phe Glu Lys Lys Gly Lys
210 215 220
Arg Met His Pro Phe Met Leu Cys Phe Met Leu Ser Gly Asp Pro Gln
225 230 235 240
Leu Val Ser Arg Ala Glu Arg Leu Ala Arg Gln Asp Asp Arg Leu Lys
245 250 255
Ala Leu Asp Glu Gly Phe Tyr Trp Leu Asp Ser His Pro Gly Glu Val
260 265 270
Ala Arg Arg Phe Arg Asn Phe Arg Ser Arg Leu Gln Ile Glu Phe Ala
275 280 285
Gln Asn Leu Val Asp Arg Tyr Ala Ala Ala Asn Arg Asp Tyr Cys Asp
290 295 300
Gln Leu Val Lys Asp Gly Lys Tyr Gly Ser Val His Lys Ile Pro Tyr
305 310 315 320
Glu Leu Phe Glu Lys Pro Thr Ser Pro Leu Ser Leu Pro Asp Asn Phe
325 330 335
Tyr Ser Val Asp Ile Val Val Leu Gly His Asn Ile Cys Lys Phe Asp
340 345 350
Glu Leu Leu Leu Ala Thr Glu Leu Val Glu Arg Arg Asp Leu Phe Pro
355 360 365
Glu Ala Cys Lys Cys Asp Arg Ser Phe Met Pro Arg Val Gly Arg Leu
370 375 380
Leu Phe Asn Asp Ile Ile Phe Arg Met Pro Asn Pro Asn Tyr Val Lys
385 390 395 400
Lys Asp Ala Ser Arg Val Glu Arg Trp Ser Arg Gly Ile Val Ser Gln
405 410 415
Gln Asp Ala Arg Ser Val Phe Val Arg Phe Met Val Arg Asp Thr Leu
420 425 430
Gln Leu Thr Ser Gly Ala Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala
435 440 445
Leu Asp Leu Cys Lys Gly Gln Cys Pro Tyr Glu Ala Ile Asn Glu Phe
450 455 460
Ile Ser Thr Gly Arg Phe His Ala Asp Ala Asp Gly Phe Pro Val Glu
465 470 475 480
Arg Tyr Trp Glu Asp Pro Ser Val Ile Ala Glu Gln Lys Asn Leu Trp
485 490 495
Gln Lys Glu His Pro Gly Gln Gln Tyr Asp Ile Val Gln Ala Cys Leu
500 505 510
Glu Tyr Cys Met Gln Asp Val Arg Val Thr Gln Lys Leu Ala His Thr
515 520 525
Leu His Asp Ser Tyr Asp Ala Tyr Phe Gln Arg Glu Leu Gly Met Glu
530 535 540
Gly His Phe Asn Ile Phe Val Arg Pro Thr Ile Pro Ser Asn Thr His
545 550 555 560
Ala Phe Trp Lys Gln Leu Thr Phe Ser Asn Tyr Val Arg Glu Gln Arg
565 570 575
Ala Thr Cys Pro Pro Ser Val Pro Glu Pro His Lys Lys Lys Gly Arg
580 585 590
Thr Lys Lys Lys Lys Gln Pro Ser Pro Asp Tyr Val Ala Glu Val Tyr
595 600 605
Ala Pro His Arg Pro Met Phe Lys Tyr Ile Arg Gln Ala Leu Arg Gly
610 615 620
Gly Arg Cys Tyr Pro Asn Val Leu Gly Pro Tyr Leu Lys Pro Val Tyr
625 630 635 640
Val Phe Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met
645 650 655
Pro His Gly Met Pro Leu Asp Pro Lys Phe Thr Ala Gln His Val Gly
660 665 670
Glu Leu Asn Arg Leu Leu Thr Asn Glu Ser His Leu Ser Tyr Phe Asp
675 680 685
Ala Arg Ile Lys Pro Ser Ile Leu Lys Ile Glu Ala Tyr Pro Pro Pro
690 695 700
Pro Glu Met Leu Asp Pro Leu Pro Pro Ile Cys Ser Arg Arg Gly Gly
705 710 715 720
Arg Leu Val Trp Thr Asn Glu Ala Leu Tyr Asp Glu Val Val Thr Val
725 730 735
Ile Asp Ile Leu Thr Leu His Asn Arg Gly Trp Arg Val Gln Val Leu
740 745 750
His Asp Glu Met Asn Ile Val Phe Pro Glu Trp Lys Thr Leu Cys Ala
755 760 765
Asp Tyr Val Thr Lys Asn Ile Leu Ala Lys Glu Lys Ala Asp Arg Glu
770 775 780
Lys Asn Glu Val Ile Arg Ser Ile Ser Lys Met Leu Ser Asn Ala Leu
785 790 795 800
Tyr Gly Ala Phe Ala Thr Asn Met Asp Thr Thr Arg Ile Ile Phe Glu
805 810 815
Gln Asp Leu Ser Glu Ala Asp Lys Lys Asn Ile Tyr Glu Gly Thr Glu
820 825 830
Ile Val Lys His Val Thr Leu Leu Asn Asp Asp Ser Phe Asn Gly Thr
835 840 845
Glu Val Thr Leu Glu Ser Ala Pro Asn Pro Phe Ser Glu Glu Ser Leu
850 855 860
Arg Gln Gln Phe Arg Tyr Ala Asp Asp Pro Glu Gln Glu Glu Pro Glu
865 870 875 880
Ala Glu Glu Asp Glu Glu Glu Glu Gly Asp Asp Ser Asp Arg Glu Ser
885 890 895
Ala Arg Lys Pro Lys Asn Ala Leu Thr Glu Asp Asp Pro Leu Val Ala
900 905 910
Val Asp Leu Glu Val Glu Ala Thr Leu Ala Thr Gly Pro Tyr Ile Pro
915 920 925
Glu Gly Glu Leu Ser Ser Ala His Tyr Ala Arg Ala Asn Glu Thr Arg
930 935 940
Phe Lys Pro Met Arg Leu Leu Glu Ala Thr Pro Glu Ala Leu Thr Val
945 950 955 960
Leu His Leu Glu Asn Leu Asp Lys Gln Val Ala Asn Lys Arg Tyr Ala
965 970 975
Thr Gln Ile Ala Cys Phe Val Leu Gly Trp Ser Arg Ala Phe Phe Ser
980 985 990
Glu Trp Cys Asp Ile Leu Tyr Gly Pro Asp Arg Gly Val His Ile Leu
995 1000 1005
Arg Arg Glu Glu Pro Arg Ser Leu Tyr Gly Asp Thr Asp Ser Leu
1010 1015 1020
Phe Val Thr Glu Thr Gly Tyr His Arg Met Lys Ser Arg Gly Ala
1025 1030 1035
His Arg Ile Lys Thr Glu Ser Thr Arg Leu Thr Phe Asp Pro Glu
1040 1045 1050
Asn Pro Gly Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys Lys
1055 1060 1065
Ala Cys Gly Ser Asp Thr Tyr Ser Ser Glu Thr Ile Phe Leu Ala
1070 1075 1080
Pro Lys Leu Tyr Gly Leu Lys Asn Ser Ile Cys Val Asn Glu Gln
1085 1090 1095
Cys Arg Thr Val Gly Pro Gly Lys Ile Arg Ser Lys Gly His Arg
1100 1105 1110
Gln Ser Glu Leu Ile Tyr Asp Thr Leu Leu Arg Cys Trp Arg Arg
1115 1120 1125
His Glu Asp Val Gln Phe Gly Ala Gln Ser Asn Ile Pro Glu Leu
1130 1135 1140
His Thr Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val
1145 1150 1155
Ser Arg Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg
1160 1165 1170
Val Leu Arg Pro Trp Lys Asp Leu Thr Leu Tyr Glu His Gly Asp
1175 1180 1185
Tyr Leu Tyr Pro Tyr Asp Asn Glu His Pro Asn Pro Arg Thr Ala
1190 1195 1200
Gly Asp Val Arg Pro Val Pro Ile Val Gly His Glu Asp Pro Leu
1205 1210 1215
Ala Pro Leu Arg Trp Glu Pro Tyr Ala Phe Leu Ser Glu Glu Glu
1220 1225 1230
Cys Gly Gln Val His Asp Leu Leu Phe Ala Asp Asp Ser Ser Gln
1235 1240 1245
Glu Ala Glu Ser Leu Gly Val
1250 1255
<210> 10
<211> 1121
<212> PRT
<213> 禽腺病毒A（Fowl adenovirus A）
<400> 10
Met Leu Ile Ala Lys Asn Val Thr Gly Glu Trp Val Trp Ile Thr Ser
1 5 10 15
Arg Thr Pro Val Gln Gln Cys Pro Thr Cys Gly Arg His Trp Val Arg
20 25 30
Arg His Ser Cys Asn Glu Arg Arg Ser Ala Phe Tyr Tyr His Ala Val
35 40 45
Gln Gly Ser Gly Ser Asp Leu Trp Gln His Val His Phe Ser Cys Pro
50 55 60
Ala Gln His Pro His Ile Arg Gln Leu Tyr Ile Thr Tyr Asp Ile Glu
65 70 75 80
Thr Tyr Thr Val Phe Glu Lys Lys Gly Lys Arg Met His Pro Phe Met
85 90 95
Leu Cys Phe Met Leu Ser Gly Asp Pro Gln Leu Val Ser Arg Ala Glu
100 105 110
Arg Leu Ala Arg Gln Asp Asp Arg Leu Lys Ala Leu Asp Glu Gly Phe
115 120 125
Tyr Trp Leu Asp Ser His Pro Gly Glu Val Ala Arg Arg Phe Arg Asn
130 135 140
Phe Arg Ser Arg Leu Gln Ile Glu Phe Ala Gln Asn Leu Val Asp Arg
145 150 155 160
Tyr Ala Ala Ala Asn Arg Asp Tyr Cys Asp Gln Leu Val Lys Asp Gly
165 170 175
Lys Tyr Gly Ser Val His Lys Ile Pro Tyr Glu Leu Phe Glu Lys Pro
180 185 190
Thr Ser Pro Leu Ser Leu Pro Asp Asn Phe Tyr Ser Val Asp Ile Val
195 200 205
Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr
210 215 220
Glu Leu Val Glu Arg Arg Asp Leu Phe Pro Glu Ala Cys Lys Cys Asp
225 230 235 240
Arg Ser Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Ile Ile
245 250 255
Phe Arg Met Pro Asn Pro Asn Tyr Val Lys Lys Asp Ala Ser Arg Val
260 265 270
Glu Arg Trp Ser Arg Gly Ile Val Ser His Gln Asp Ala Arg Ser Val
275 280 285
Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Leu Thr Ser Gly Ala
290 295 300
Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Asp Leu Cys Lys Gly
305 310 315 320
His Cys Pro Tyr Glu Ala Ile Asn Glu Phe Ile Ser Thr Gly Arg Phe
325 330 335
His Ala Asp Ala Asp Gly Phe Pro Val Glu Arg Tyr Trp Glu Asp Pro
340 345 350
Ser Val Ile Ala Glu Gln Lys Asn Leu Trp Gln Lys Glu His Pro Gly
355 360 365
Gln Gln Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp
370 375 380
Val Arg Val Thr Gln Lys Leu Ala His Thr Leu His Asp Ser Tyr Asp
385 390 395 400
Ala Tyr Phe Gln Arg Glu Leu Gly Met Glu Gly His Phe Asn Ile Phe
405 410 415
Val Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu
420 425 430
Thr Phe Ser Asn Tyr Val Arg Glu Gln Arg Ala Thr Cys Pro Pro Ser
435 440 445
Val Pro Glu Pro Pro Lys Lys Lys Gly Arg Thr Lys Lys Lys Lys Gln
450 455 460
Pro Ser Pro Asp Tyr Val Ala Glu Val Tyr Ala Pro His Arg Pro Met
465 470 475 480
Phe Lys Tyr Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Asn
485 490 495
Val Leu Gly Pro Tyr Leu Lys Pro Val Tyr Val Phe Asp Ile Cys Gly
500 505 510
Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu
515 520 525
Asp Pro Lys Phe Thr Ala Gln His Val Glu Glu Leu Asn Arg Leu Leu
530 535 540
Thr Asn Glu Ser His Leu Ser Tyr Phe Asp Ala Arg Ile Lys Pro Ser
545 550 555 560
Ile Leu Lys Ile Glu Ala Tyr Pro Pro Pro Pro Glu Met Leu Asp Pro
565 570 575
Leu Pro Pro Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn
580 585 590
Glu Ala Leu Tyr Asp Glu Val Val Thr Val Ile Asp Ile Leu Thr Leu
595 600 605
His Asn Arg Gly Trp Arg Val Gln Val Leu His Asp Glu Met Asn Ile
610 615 620
Val Phe Pro Glu Trp Lys Thr Leu Cys Ala Asp Tyr Val Thr Lys Asn
625 630 635 640
Ile Leu Ala Lys Glu Lys Ala Asp Arg Glu Lys Asn Glu Val Ile Arg
645 650 655
Ser Ile Ser Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr
660 665 670
Asn Met Asp Thr Thr Arg Ile Ile Phe Glu Gln Asp Leu Ser Glu Ala
675 680 685
Asp Lys Lys Asn Ile Tyr Glu Gly Thr Glu Ile Val Lys His Val Thr
690 695 700
Leu Leu Asn Asp Asp Ser Phe Asn Gly Thr Glu Val Thr Leu Glu Asn
705 710 715 720
Ala Pro Asn Pro Phe Ser Glu Glu Ser Leu Arg Gln Gln Phe Arg Tyr
725 730 735
Ala Asp Asp Pro Glu Gln Glu Glu Pro Glu Ala Glu Glu Asp Gly Glu
740 745 750
Glu Glu Gly Asp Asp Ser Asp Arg Glu Ser Ala Arg Lys Pro Lys Asn
755 760 765
Ala Leu Thr Glu Asp Asp Pro Leu Val Ala Val Asp Leu Glu Val Glu
770 775 780
Ala Thr Leu Ala Thr Gly Pro Tyr Ile Pro Glu Gly Glu Leu Ser Ser
785 790 795 800
Ala His Tyr Ala Arg Ala Asn Glu Thr Arg Phe Lys Pro Met Arg Leu
805 810 815
Leu Glu Ala Thr Pro Glu Ala Leu Thr Val Leu His Leu Glu Ser Leu
820 825 830
Asp Lys Gln Val Ala Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe
835 840 845
Val Leu Gly Trp Ser Arg Ala Phe Phe Ser Glu Trp Cys Asp Ile Leu
850 855 860
Tyr Gly Pro Asp Arg Gly Val His Ile Leu Arg Arg Glu Glu Pro Arg
865 870 875 880
Ser Leu Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Thr Gly Tyr
885 890 895
His Arg Met Lys Ser Arg Gly Ala His Arg Ile Lys Thr Glu Ser Thr
900 905 910
Arg Leu Thr Phe Asp Pro Glu Asn Pro Gly Leu Tyr Trp Ala Cys Asp
915 920 925
Cys Asp Ile Lys Cys Lys Ala Cys Gly Ser Asp Thr Tyr Ser Ser Glu
930 935 940
Thr Ile Phe Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ser Ile Cys
945 950 955 960
Val Asn Glu Gln Cys Arg Thr Val Gly Pro Gly Lys Ile Arg Ser Lys
965 970 975
Gly His Arg Gln Ser Glu Leu Ile Tyr Asp Thr Leu Leu Arg Cys Trp
980 985 990
Arg Arg His Glu Asp Val Gln Phe Gly Ala Gln Ser Asn Ile Pro Glu
995 1000 1005
Leu His Thr Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys
1010 1015 1020
Val Ser Arg Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr
1025 1030 1035
Arg Val Leu Arg Pro Trp Lys Asp Leu Thr Leu Tyr Glu His Gly
1040 1045 1050
Asp Tyr Leu Tyr Pro Tyr Asp Asn Glu His Pro Asn Pro Arg Thr
1055 1060 1065
Thr Gly Asp Val Arg Pro Val Pro Ile Val Gly His Glu Asp Pro
1070 1075 1080
Leu Ala Pro Leu Arg Trp Glu Pro Tyr Ala Phe Leu Ser Glu Glu
1085 1090 1095
Glu Cys Gly Gln Val His Asp Leu Leu Phe Ala Asp Asp Ser Ser
1100 1105 1110
Gln Glu Ala Glu Ser Leu Gly Val
1115 1120
<210> 11
<211> 1159
<212> PRT
<213> 禽腺病毒9（Fowl adenovirus 9）
<400> 11
Met Leu Val Thr Gln Asp Gln Asn Gly Asp Trp Val Trp Ile Leu Ser
1 5 10 15
Arg Thr Ala Val Gln Thr Cys Pro Ala Cys Gly Arg His Trp Val Arg
20 25 30
Asn His Thr Cys Asn Glu Arg Arg Ser Ala Phe Phe Tyr His Thr Val
35 40 45
Gln Lys Phe Gly Cys Asp Leu Trp Gln His Val Arg Phe Ala Cys Pro
50 55 60
Ala Gln Gln Pro His Cys Lys Gln Leu Phe Leu Thr Tyr Asp Ile Glu
65 70 75 80
Thr Tyr Thr Val Phe Glu Asn Lys Gly Lys Arg Met His Pro Phe Met
85 90 95
Leu Cys Phe Met Leu Thr Gly Asp Pro Asp Val Val Arg Ala Ala Thr
100 105 110
Asp Leu Ala Leu Val Asp Pro Glu Val Lys Thr Leu Gln Glu Gly Phe
115 120 125
Tyr Trp Leu Asp Thr Arg Pro Gly Phe Val Ala Arg Arg Phe Arg Ala
130 135 140
Tyr Arg Ser Arg Leu Gln Gln His Phe Ala Arg Asp Leu Val Asp Arg
145 150 155 160
Tyr Cys Arg Ala Asn Gly Asp Tyr Val Ser Lys Leu Met Ser Glu Gly
165 170 175
Lys Tyr Leu Ser Arg Tyr Asp Ile Pro Tyr Glu Leu Phe Asp Lys Pro
180 185 190
Thr Glu Pro Leu Lys Leu Pro Asp Asp Phe Asn Asn Val His Ile Val
195 200 205
Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr
210 215 220
Glu Leu Val Glu Arg Arg Asp Val Phe Pro Gln Ala Cys Arg Cys Asp
225 230 235 240
Arg Phe Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Val Leu
245 250 255
Phe His Leu Pro Asn Pro Asn Tyr Asp Lys Lys Asp Pro Thr Arg Leu
260 265 270
His Arg Trp Ala Arg Gly Val Val Ala Pro Ser Asp Ser Arg Thr Val
275 280 285
Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Phe Thr Ser Gly Ala
290 295 300
Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Glu Leu Ser Lys Gly
305 310 315 320
Gln Cys Pro Tyr Glu Ala Val Asn Glu His Val Ser Ile Gly Gly Tyr
325 330 335
Glu Gln Asp Ser Asp Gly Phe Pro Val Ala Arg Tyr Trp Glu Asp Pro
340 345 350
Ser Val Ile Ala Glu Gln Lys Ala Leu Trp Arg Gln Glu His Pro Gly
355 360 365
Arg Pro Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp
370 375 380
Val Arg Val Thr Gln Lys Leu Ala Leu Thr Leu Tyr Asp Ser Tyr Asp
385 390 395 400
Lys Tyr Phe Lys Asp Glu Leu Gly Met His Gly Asp Phe Asn Ile Phe
405 410 415
Leu Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu
420 425 430
Thr Phe Thr Ala Tyr Val Glu Glu Gln Glu Arg Ala Ser Thr Val Glu
435 440 445
Arg Pro Pro Ser Lys Tyr Lys Arg Lys Val Ala Leu Lys Lys Asn Asp
450 455 460
Ile Lys Gly Asn Pro His Asp Ala Asp Val His Asp Val Glu Arg Ala
465 470 475 480
Ser Ala Asn Lys Asn Thr Lys Lys Arg Lys Lys Arg Leu Pro Ser Pro
485 490 495
Glu Tyr Val Ala Glu Ile Tyr Ala Pro His Arg Pro Met Phe Lys Tyr
500 505 510
Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Ser Val Leu Gly
515 520 525
Pro Tyr Arg His Pro Val Tyr Val Phe Asp Ile Cys Gly Met Tyr Ala
530 535 540
Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu Asp Pro Lys
545 550 555 560
Phe Thr Ala Lys His Val Asp Glu Leu Asn Glu Leu Met Ser Ser Glu
565 570 575
Arg Pro Ile Ser Tyr Phe Asp His Arg Ile Lys Pro Cys Ile Leu Lys
580 585 590
Val Glu Ala Tyr Pro Pro Pro Ala Glu His Leu Asp Thr Leu Pro Pro
595 600 605
Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn Glu Ala Leu
610 615 620
Tyr Asp Glu Val Ile Thr Val Ile Asp Ile Leu Thr Leu His Asn Arg
625 630 635 640
Gly Trp Ala Val Thr Ala Leu His Asp Asp Met Asn Ile Val Phe Pro
645 650 655
Ala Trp Lys Thr Val Cys Ala Glu Tyr Val Ser Lys Asn Ile Ala Ala
660 665 670
Lys Glu Lys Ala Asp Arg Asp Lys Asn Glu Val Met Arg Ser Ile Ser
675 680 685
Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr Asn Met Asp
690 695 700
Thr Thr Arg Ile Leu Phe Glu Gln Asp Leu Thr Glu Asp Asp Arg Arg
705 710 715 720
Gly Ile Tyr Glu Gly Thr Gln Ile Val Arg His Val Thr Leu Leu Asn
725 730 735
His Asp Ser Leu Ala Gly Thr Val Val Cys Pro Glu Ser Thr Pro Asp
740 745 750
Ala Phe Arg His His Gln Leu Arg Gln Tyr Phe Asp Arg Lys Pro Pro
755 760 765
Thr Arg Thr Ala Glu Glu Glu Asn Glu Glu Gln Glu Glu Glu Glu Thr
770 775 780
Glu Glu Ser Glu Gly Glu Ser Thr Ser Lys Leu Glu Asn Ala Leu Thr
785 790 795 800
Ala Arg Glu Ala Ser Leu Ala Glu Val Asp His Gln Leu Gln Glu Ala
805 810 815
Leu Asp Ala Pro Pro Tyr Ile Ala Glu Asp Asp His Ala His Tyr Ala
820 825 830
Thr Ala Asn Glu Thr Val Phe Lys Pro Met Arg Leu Leu Asp Ala Pro
835 840 845
Pro Glu Ala Leu Thr Val Leu His Leu Glu Asn Leu Asp Lys Met Val
850 855 860
Glu Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe Val Leu Gly Trp
865 870 875 880
Ser Arg Ala Phe Phe Ser Glu Trp Cys Glu Ile Leu His Gly Pro Asp
885 890 895
Arg Gly Thr His Leu Leu Gln Arg Asp Pro Gln Thr Leu Tyr Gly Asp
900 905 910
Thr Asp Ser Leu Phe Val Thr Glu Ser Gly Tyr Arg Arg Met Lys Glu
915 920 925
Arg Gly Ala His Arg Ile Lys Gly Pro His Thr Arg Leu Thr Phe Asp
930 935 940
Pro Glu Asn Pro Ala Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys
945 950 955 960
Lys Arg Cys Gly Gly Asp Thr Tyr Ser Ser Glu Ala Ile Phe Leu Ala
965 970 975
Pro Lys Leu Tyr Gly Leu Lys Asp Ala Val Cys Leu Asp Pro Glu Cys
980 985 990
Gly His Val Gly Ser Gly Lys Ile Arg Ser Lys Gly His Arg Gln Ala
995 1000 1005
Glu Leu Ile Tyr Asp Thr Leu Glu Arg Cys Trp Gln Arg His Glu
1010 1015 1020
Asp Gln Ser Tyr Gly Ala Val Ser Ala Ile Pro Glu Leu His Thr
1025 1030 1035
Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val Ser Arg
1040 1045 1050
Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg Val Leu
1055 1060 1065
Arg Pro Trp Lys Asp Leu Thr Gln Tyr Arg His Gly Asp Phe Leu
1070 1075 1080
Tyr Pro Tyr Asp Thr Glu His Pro Asn Pro Arg Thr Ala Asp Glu
1085 1090 1095
Val Arg Arg Val Pro Pro Val Gly His Glu Glu Pro Leu Ala Pro
1100 1105 1110
Leu Arg Leu Leu Ala Ala Ala Ala Ala Ala Arg Ile Ala Pro Glu
1115 1120 1125
Asp Asp Gly Glu Asp Ser Asp Glu Phe Asp Val Pro Asp Arg Ser
1130 1135 1140
Leu Ser Ile Glu Asp Cys Asp Glu Ile Leu Asp Leu Leu Gly Asp
1145 1150 1155
Pro
<210> 12
<211> 1159
<212> PRT
<213> 禽腺病毒D（Fowl adenovirus D）
<400> 12
Met Leu Val Thr Gln Asp Gln Asn Gly Asp Trp Val Trp Ile Leu Ser
1 5 10 15
Arg Thr Ala Val Gln Thr Cys Pro Ala Cys Gly Arg His Trp Val Arg
20 25 30
Asn His Thr Cys Asn Glu Arg Arg Ser Ala Phe Phe Tyr His Thr Val
35 40 45
Gln Lys Phe Gly Cys Asp Leu Trp Gln His Val Arg Phe Ala Cys Pro
50 55 60
Ala Gln Gln Pro His Cys Lys Gln Leu Phe Leu Thr Tyr Asp Ile Glu
65 70 75 80
Thr Tyr Thr Val Phe Glu Asn Lys Gly Lys Arg Met His Pro Phe Met
85 90 95
Leu Cys Phe Met Leu Thr Gly Asp Pro Asp Val Val Arg Ala Ala Thr
100 105 110
Asp Leu Ala Leu Val Asp Pro Glu Val Lys Thr Leu Gln Glu Gly Phe
115 120 125
Tyr Trp Leu Asp Thr Arg Pro Gly Phe Val Ala Arg Arg Phe Arg Ala
130 135 140
Tyr Arg Ser Arg Leu Gln Gln His Phe Ala Arg Asp Leu Val Asp Arg
145 150 155 160
Tyr Cys Arg Ala Asn Gly Asp Tyr Val Ser Lys Leu Met Ser Glu Gly
165 170 175
Lys Tyr Leu Ser Arg Tyr Asp Ile Pro Tyr Glu Leu Phe Asp Lys Pro
180 185 190
Thr Glu Pro Leu Lys Leu Pro Asp Asp Phe Asn Asn Val His Ile Val
195 200 205
Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr
210 215 220
Glu Leu Val Glu Arg Arg Asp Val Phe Pro Gln Ala Cys Arg Cys Asp
225 230 235 240
Arg Phe Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Val Leu
245 250 255
Phe His Leu Pro Asn Pro Asn Tyr Asp Lys Lys Asp Pro Thr Arg Leu
260 265 270
His Arg Trp Ala Arg Gly Val Val Ala Pro Ser Asp Ser Arg Thr Val
275 280 285
Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Phe Thr Ser Gly Ala
290 295 300
Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Glu Leu Ser Lys Gly
305 310 315 320
Gln Cys Pro Tyr Glu Ala Val Asn Glu His Val Ser Ile Gly Gly Tyr
325 330 335
Glu Gln Asp Ser Asp Gly Phe Pro Val Ala Arg Tyr Trp Glu Asp Pro
340 345 350
Ser Val Ile Ala Glu Gln Lys Ala Leu Trp Arg Gln Glu His Pro Gly
355 360 365
Arg Pro Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp
370 375 380
Val Arg Val Thr Gln Lys Leu Ala Leu Thr Leu Tyr Asp Ser Tyr Asp
385 390 395 400
Lys Tyr Phe Lys Asp Glu Leu Gly Met His Gly Asp Phe Asn Ile Phe
405 410 415
Leu Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu
420 425 430
Thr Phe Thr Ala Tyr Val Glu Glu Gln Glu Arg Ala Ser Thr Val Glu
435 440 445
Arg Pro Pro Ser Lys Tyr Lys Arg Lys Val Ala Leu Lys Lys Asn Asp
450 455 460
Ile Lys Gly Asn Pro His Asp Ala Asp Val His Asp Val Glu Arg Ala
465 470 475 480
Ser Ala Asn Lys Asn Thr Lys Lys Arg Lys Lys Arg Leu Pro Ser Pro
485 490 495
Glu Tyr Val Ala Glu Ile Tyr Ala Pro His Arg Pro Met Phe Lys Tyr
500 505 510
Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Ser Val Leu Gly
515 520 525
Pro Tyr Arg His Pro Val Tyr Val Phe Asp Ile Cys Gly Met Tyr Ala
530 535 540
Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu Asp Pro Lys
545 550 555 560
Phe Thr Ala Lys His Val Asp Glu Leu Asn Glu Leu Met Ser Ser Glu
565 570 575
Arg Pro Ile Ser Tyr Phe Asp His Arg Ile Lys Pro Cys Ile Leu Lys
580 585 590
Val Glu Ala Tyr Pro Pro Pro Ala Glu His Leu Asp Thr Leu Pro Pro
595 600 605
Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn Glu Ala Leu
610 615 620
Tyr Asp Glu Val Ile Thr Val Ile Asp Ile Leu Thr Leu His Asn Arg
625 630 635 640
Gly Trp Ala Val Thr Ala Leu His Asp Asp Met Asn Ile Val Phe Pro
645 650 655
Ala Trp Lys Thr Val Cys Ala Glu Tyr Val Ser Lys Asn Ile Ala Ala
660 665 670
Lys Glu Lys Ala Asp Arg Asp Lys Asn Glu Val Met Arg Ser Ile Ser
675 680 685
Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr Asn Met Asp
690 695 700
Thr Thr Arg Ile Leu Phe Glu Gln Asp Leu Thr Glu Asp Asp Arg Arg
705 710 715 720
Gly Ile Tyr Glu Gly Thr Gln Ile Val Arg His Val Thr Leu Leu Asn
725 730 735
His Asp Ser Leu Ala Gly Thr Val Val Cys Pro Glu Ser Thr Pro Asp
740 745 750
Ala Phe Arg His His Gln Leu Arg Gln Tyr Phe Asp Arg Lys Pro Pro
755 760 765
Thr Arg Thr Ala Glu Glu Glu Asn Glu Glu Gln Glu Glu Glu Glu Thr
770 775 780
Glu Glu Ser Glu Gly Glu Ser Thr Ser Lys Leu Glu Asn Ala Leu Thr
785 790 795 800
Ala Arg Glu Ala Ser Leu Ala Glu Val Asp His Gln Leu Gln Glu Ala
805 810 815
Leu Asp Ala Pro Pro Tyr Ile Ala Glu Asp Asp His Ala His Tyr Ala
820 825 830
Thr Ala Asn Glu Thr Val Phe Lys Pro Met Arg Leu Leu Asp Ala Pro
835 840 845
Pro Glu Ala Leu Thr Val Leu His Leu Glu Asn Leu Asp Lys Met Val
850 855 860
Glu Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe Val Leu Gly Trp
865 870 875 880
Ser Arg Ala Phe Phe Ser Glu Trp Cys Glu Ile Leu His Gly Pro Asp
885 890 895
Arg Gly Thr His Leu Leu Gln Arg Asp Pro Gln Thr Leu Tyr Gly Asp
900 905 910
Thr Asp Ser Leu Phe Val Thr Glu Ser Gly Tyr Arg Arg Met Lys Glu
915 920 925
Arg Gly Ala His Arg Ile Lys Gly Pro His Thr Arg Leu Thr Phe Asp
930 935 940
Pro Glu Asn Pro Ala Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys
945 950 955 960
Lys Arg Cys Gly Gly Asp Thr Tyr Ser Ser Glu Ala Ile Phe Leu Ala
965 970 975
Pro Lys Leu Tyr Gly Leu Lys Asp Ala Val Cys Leu Asp Pro Glu Cys
980 985 990
Gly His Val Gly Ser Gly Lys Ile Arg Ser Lys Gly His Arg Gln Ala
995 1000 1005
Glu Leu Ile Tyr Asp Thr Leu Glu Arg Cys Trp Gln Arg His Glu
1010 1015 1020
Asp Gln Ser Tyr Gly Ala Val Ser Ala Ile Pro Glu Leu His Thr
1025 1030 1035
Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val Ser Arg
1040 1045 1050
Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg Val Leu
1055 1060 1065
Arg Pro Trp Lys Asp Leu Thr Gln Tyr Arg His Gly Asp Phe Leu
1070 1075 1080
Tyr Pro Tyr Asp Thr Glu His Pro Asn Pro Arg Thr Ala Asp Glu
1085 1090 1095
Val Arg Arg Val Pro Pro Val Gly His Glu Glu Pro Leu Ala Pro
1100 1105 1110
Leu Arg Leu Leu Ala Ala Ala Ala Ala Ala Arg Ile Ala Pro Glu
1115 1120 1125
Asp Asp Gly Glu Asp Ser Asp Glu Phe Asp Val Pro Asp Arg Ser
1130 1135 1140
Leu Ser Ile Glu Asp Cys Asp Glu Ile Leu Asp Leu Leu Gly Asp
1145 1150 1155
Pro
<210> 13
<211> 1085
<212> PRT
<213> 蛇腺病毒1（Snake adenovirus 1）
<400> 13
Met Glu Ala Ser Thr Thr Thr Val Lys Ala Arg Ser Thr His Tyr Ile
1 5 10 15
Cys Gly His Ala Gly Asp Ser Phe Val Lys Ile Ile Tyr Tyr Lys Asp
20 25 30
Lys Val Lys Ala Val Val Ser Tyr Leu Asn Met Asn Asp Tyr Leu Asn
35 40 45
Thr Tyr Ala Leu Lys Cys Val Ile Pro Glu Lys Ile Thr Lys Asp Phe
50 55 60
Phe Ser Ser Cys Pro Asp Asp Leu Leu Tyr Ser Thr Leu Ala Ser Ile
65 70 75 80
Gln Arg Gly Tyr Ser Pro Lys Lys Lys Glu Glu Leu Gly Gly Lys Trp
85 90 95
Glu Pro Leu Leu Leu Leu Tyr His Arg Gly Glu Glu Tyr Ile Ile Arg
100 105 110
Ala Val Val Pro Gln Arg Arg Cys Glu Asp Cys Gly Lys Gln Phe Val
115 120 125
Ser Ser His Gln Cys Asn Val Arg Arg Arg Glu Phe Tyr His His Ala
130 135 140
Val Leu Pro Asp Thr Lys Thr Trp Trp Lys Pro Ile Lys Phe Ser Pro
145 150 155 160
Ile Gly Ala Leu Ser Asn Ala Lys Arg Leu Phe Ile Ile Tyr Asp Ile
165 170 175
Glu Thr Tyr Thr Phe His Ser Gly Tyr Gly Lys Gln Leu Val Pro Tyr
180 185 190
Leu Leu Val Met Gln Phe Lys Gly Asp Ser Arg Leu Arg Cys Glu Ala
195 200 205
Glu Lys Ile Ala Leu Glu Cys Gly Phe Gln Pro Tyr Arg Gln Cys Phe
210 215 220
Met Met Leu Asn Lys Ala Arg Asp Val Ile Gly His Lys Phe Lys Asp
225 230 235 240
Met Arg Val Gln Leu Gln Lys Arg Ala Ala Ser Asp Ile Trp Ser Arg
245 250 255
Tyr Arg Glu Lys His Asp Ile Leu Ser Glu Glu Gly Val Ser Tyr Ala
260 265 270
Gln Leu Glu Ala Met Ala Lys Asp Asn Leu Leu Lys Thr Asp Ala Glu
275 280 285
Pro Glu Phe Thr Glu Ile Ile Val Val Gly His Asn Ile Thr Gly Phe
290 295 300
Asp Glu Ile Val Leu Ala Ser His Val Leu Glu Gly Leu Pro Lys Asp
305 310 315 320
Glu Glu Leu Gln Met Phe Lys Ile Thr Arg Asn Phe Met Pro Arg Ala
325 330 335
Gly Lys Leu Leu Phe Asn Asp Val Ile Met Ala Leu Pro Asn Ala Ala
340 345 350
Phe Gln Lys Pro Lys Gln Ser Thr Phe Gln Arg Trp Lys Thr Gly Asp
355 360 365
Leu Arg Pro Glu Asp Leu Lys Trp Glu Gly Val Arg Phe Met Val Arg
370 375 380
Asp Thr Val Leu Leu Thr His Ser Ser Leu Arg Asn Ala Ala Gln Ala
385 390 395 400
Tyr Gln Leu Glu Val Ser Lys Gly His Cys Pro Tyr Asp Ala Leu Asn
405 410 415
Gln Tyr Phe Met Val Gly Thr Tyr Leu Cys Asp Glu Asn Met Tyr Pro
420 425 430
Ala Arg Glu Tyr Trp Ser Ser Asp Glu Glu Tyr Leu Glu Asn Lys Pro
435 440 445
Pro Asp Gly Glu Lys Tyr Asp Leu Val Gln Lys Ala Val Asp Tyr Cys
450 455 460
Val Asn Asp Val Lys Val Thr Val Ala Leu Val Lys Lys Leu Cys Ser
465 470 475 480
Gly Tyr Gln Gln Phe Cys Asp Glu Val Leu Lys Leu Asp Cys Thr Phe
485 490 495
Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Thr Thr His Ala Met Phe
500 505 510
Lys Gln Met Phe Tyr Lys Ser Glu Pro Ser Ala Val Gly Lys Phe Leu
515 520 525
Pro Asn Leu Glu Ala Pro Ser Glu Val Met Tyr Glu His Ile Arg Lys
530 535 540
Ser Val Arg Gly Gly Arg Cys Tyr Pro Ser Phe Leu Gly Val Phe Thr
545 550 555 560
Glu Pro His Leu Cys Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu
565 570 575
Ser His Pro Met Pro Tyr Gly Pro Thr Leu Ser Pro Phe Asp Ser Ala
580 585 590
Val Ala Ile Ala Glu Phe Gln Arg Lys Leu Asp Gly Gln Ser Glu Leu
595 600 605
Ser Tyr Phe Asp Pro Asp Ile Phe Pro Met Ile Val Val Ala Asp Ala
610 615 620
Phe Pro Pro Ser Leu His Cys Leu Asp Val Leu Pro Pro Leu Cys Ser
625 630 635 640
Lys Arg Ser Gly Lys Leu Cys Trp Thr Asn Glu Pro Leu Leu Gly Glu
645 650 655
Val Leu Thr Thr Val Asp Leu Ile Met Leu Lys Asn Arg Gly Trp Arg
660 665 670
Val Lys Leu Ile Gln Asn Ala Glu Cys Tyr Ala Val Trp Arg Glu Trp
675 680 685
Arg Pro Leu Cys Arg Glu Tyr Val Ser Ile Asn Ile Ala Ala Lys Glu
690 695 700
Lys Ala Asp Arg Glu Lys Asn Gln Thr Gln Arg Ser Ile Ser Lys Leu
705 710 715 720
Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg Leu Asp Asn Lys
725 730 735
Gln Val Val Phe Met Asp Asp Met Ser Ser Thr Thr Gln Ser Glu Leu
740 745 750
Arg Ser Gly Lys Ala Ser Ile Val Ser Met Thr Ser Val Cys Ser Arg
755 760 765
Ser Leu Pro Gln Lys Asp Thr Ser Phe Trp Glu Arg Tyr Phe Asn Leu
770 775 780
Pro Gln Val Glu Asp Ser Ile Ser Ala Glu Leu Asn Asp Glu Pro Glu
785 790 795 800
Thr Glu Pro Phe Ile Gly Gly Glu Arg Ser His Val Ile Tyr Lys Pro
805 810 815
Ile Thr Phe Leu Ser Ala Glu Cys Asp Asn Leu Leu Leu Ala Thr Val
820 825 830
Gln Ser Asn Ser Asp Trp Val Lys Asn Asp Arg Tyr Ala Thr Gln Val
835 840 845
Ala Ser Phe Val Leu Ala Trp Ser Arg Ala Phe Met Ser Glu Trp Ala
850 855 860
Thr Ile Leu Tyr Gly Glu Asp Ile Gly Val Pro Tyr Glu Gln Arg Lys
865 870 875 880
Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gly Glu
885 890 895
Gly His Arg Leu Met Ile Thr Lys Gly Arg His Lys Leu Lys Ser Ser
900 905 910
Gly Asn Ser Leu Val Tyr Arg Asp Asp Gly Asn Leu Ala Trp Leu Val
915 920 925
Glu Cys Glu Thr Ser Cys Pro Ser Cys Lys Ser Asp Ser Phe Ser Ser
930 935 940
Glu Ser Cys Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr
945 950 955 960
Cys Pro Ser Cys Gly Leu Val Ser Gly Gly Lys Leu Arg Ala Lys Gly
965 970 975
His Ala Lys Ser Cys Ile Thr Tyr Asp Val Leu Lys Ser Cys Phe Leu
980 985 990
Asp His Tyr Leu Leu Glu Arg Pro Thr Glu Gln Tyr Gln Ser Glu Arg
995 1000 1005
Thr Pro Ile Lys Arg Thr Leu Ala Asn Gly Ser Ala Asn Ser Ala
1010 1015 1020
Pro Phe Thr Val Val Glu Lys Gln Leu Ala Arg Val Ile Arg Pro
1025 1030 1035
Trp Asn Asp Pro Thr Met Ala Arg Gly Thr Asp Leu Ser Gln Gly
1040 1045 1050
Phe Leu Leu Phe Pro Tyr Asp Gln Lys Arg Pro Asn Pro Arg Pro
1055 1060 1065
Gln Glu Pro Leu Leu Glu Asn Pro Phe Trp Asp Asp Ser Ser Gln
1070 1075 1080
Thr Ala
1085
<210> 14
<211> 1073
<212> PRT
<213> 牛腺病毒4（Bovine adenovirus 4）
<400> 14
Met Ala Ser Lys Thr Ile Val Lys His Arg Thr Thr His Tyr Ile Thr
1 5 10 15
Gly Tyr Phe Glu Asp Thr Pro Ile Lys Ile Ile Tyr Tyr Lys Asp Phe
20 25 30
Lys Lys Ser Phe Phe Asn Phe Leu Gln Leu Gln Gly Leu Gln Pro Lys
35 40 45
Ala Gln Tyr Lys Ser Phe Leu Lys Pro Glu Asp Ile Leu Gln Tyr Phe
50 55 60
Ser Glu Asp Glu Tyr Pro Ser Val Ile Lys Ile Trp Lys Leu Asn Lys
65 70 75 80
Lys Phe Leu Tyr Tyr Asp Glu Cys Lys Thr Asp Gly Lys Thr Met Ala
85 90 95
Val Glu Leu Val Gln Tyr Lys Asn Ala Trp Phe Leu Val Lys Asp Ile
100 105 110
Lys Lys Gln Gln Lys Cys Glu Asn Cys Gly Val Thr Phe Asn Ser Ile
115 120 125
His Thr Cys Asn Val Lys Arg Arg Asp Phe Tyr Tyr His Phe Ile Asn
130 135 140
His Glu Thr Lys His Trp Trp Glu Gln Ile Lys Phe Asn Pro Val Gly
145 150 155 160
Ala Leu Glu Ser Thr Lys Arg Leu Phe Ile Val Tyr Asp Ile Glu Thr
165 170 175
Tyr Thr Tyr His Ser Thr Tyr Gly Lys Gln Leu Leu Pro Tyr Leu Ile
180 185 190
Val Phe Glu Leu Ile Gly Ser Lys Thr Leu Gln Lys Ile Ala Ala Gln
195 200 205
Ile Ala Tyr Asp Cys Gly Phe Met Met Glu Arg Gly Cys Phe Phe Met
210 215 220
Leu Asn His Arg His Asp Val Ile Gly Asn Ala Phe Lys Lys Phe Arg
225 230 235 240
Ile Met Ile Gln Lys Thr Val Ala Lys Asn Ile Trp Leu Arg Phe Ser
245 250 255
Lys Glu Gln Glu Ile Glu Thr Leu Leu Asn Tyr Asp Glu Ile Leu Lys
260 265 270
Leu Asn Lys Glu Lys Lys Leu Lys Leu Ala Tyr Pro Gln Tyr Val Glu
275 280 285
Ile Phe Val Ile Gly His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu
290 295 300
Ala Ser His Val Leu Glu Gly Ile Arg Asp Gln Glu Asn Leu Ala Met
305 310 315 320
Phe Asn Phe Ser Arg Ser Phe Met Pro Arg Ala Gly Lys Leu Leu Phe
325 330 335
Asn Asp Val Thr Leu Ser Leu Pro Asn Pro Cys Tyr Lys Lys Pro Asp
340 345 350
Lys Thr Thr Phe Glu Arg Trp Lys Lys Gly Ile Leu Leu Pro Glu Asp
355 360 365
Leu Pro Trp Gln Gly Leu Lys Phe Met Val Arg Asp Thr Phe Leu Leu
370 375 380
Thr His Cys Ser Leu Arg Asn Ala Ala Ala Ala Tyr Gln Leu Asn Val
385 390 395 400
Ser Lys Gly His Cys Pro Tyr Asp Ala Ile Asn Asp Tyr Phe Met Leu
405 410 415
Gly Asp Tyr Glu Lys Asp Lys Asn Gly Tyr Pro Val Glu Lys Tyr Trp
420 425 430
Lys Asp Lys Ala Glu Tyr Glu Gln Asn Lys Pro Asn Gly Gln Tyr Asn
435 440 445
Ile Ile Glu Glu Ala Lys Lys Tyr Cys Ile Asp Asp Val Lys Val Thr
450 455 460
Ala Gln Leu Val Ser Lys Leu Ile Asp Gly Tyr Gln Glu Phe Cys Asn
465 470 475 480
Ser Thr Leu Lys Leu Pro Cys Leu Phe Asn Ile Phe Gln Arg Pro Thr
485 490 495
Ile Ser Ser Asn Thr Gln Met Leu Phe Lys Gln Leu His Tyr Arg Glu
500 505 510
Glu Asn Ile Asn Ser Glu Tyr Leu Asn Asn Leu Glu Ala Pro Ser Glu
515 520 525
Lys Met Tyr Ser Phe Val Arg Ala Ser Val Arg Gly Gly Arg Cys Tyr
530 535 540
Pro Thr Phe Leu Gly Ile Tyr Thr Glu Pro Val Tyr Val Tyr Asp Ile
545 550 555 560
Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Arg
565 570 575
Thr Leu Asn Pro Phe Glu Ala Asn Thr Ser Ile Asp Glu Met Gln Asn
580 585 590
Met Leu Asp Ser Ser Glu Val Leu Ser Tyr Phe Asp Pro Arg Ile Lys
595 600 605
Ala Met Ile Val Val Ala Asp Cys Glu Pro Pro Thr Leu Glu Tyr Leu
610 615 620
Asp Val Leu Pro Pro Leu Cys Ser Lys Lys Ser Gly Lys Leu Cys Trp
625 630 635 640
Thr Asn Glu Pro Leu Ile Asn Glu Thr Val Thr Ser Ile Asp Leu Ile
645 650 655
Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Met Lys Asn Glu Leu
660 665 670
Tyr Ala Val Trp Pro Asn Trp Lys Thr Leu Cys Lys Gln Tyr Val Glu
675 680 685
Ile Asn Ile Ala Ala Lys Glu Arg Ala Asp Lys Glu Lys Asn Lys Thr
690 695 700
Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe
705 710 715 720
Ala Thr Lys Ile Asp Lys Lys Lys Val Ile Phe Ala Glu Asp Ile Glu
725 730 735
Glu Lys Asp Lys Lys Leu Leu Arg Glu Gly Lys Ser Glu Ile Thr Ser
740 745 750
Tyr Thr Thr Val Ile Ser Ser Ser Leu Pro Lys Ser Thr Asp Tyr Asp
755 760 765
Trp Asn Lys Tyr Phe Leu Asn Leu Pro Glu Val Cys Ser Thr Thr Asn
770 775 780
Lys Asn Leu Asn Glu Lys Ser Gly Lys Thr Ala Phe Ile Glu Lys Asn
785 790 795 800
Asp His Val Ile Phe Lys Pro Ile Thr Phe Leu Ser Ala Glu Cys Asn
805 810 815
Asp Leu Val Leu Thr Thr Ile Glu Asp Lys Ala Glu Trp Ile Lys Asn
820 825 830
Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg
835 840 845
Ala Phe Met Ser Glu Trp Ala Asp Ile Leu Tyr Gly Glu Asp Arg Gly
850 855 860
Lys Ser Tyr Ser Glu Arg Asp Leu Lys Ser Leu Tyr Gly Asp Thr Asp
865 870 875 880
Ser Leu Phe Leu Ser Gln Lys Gly His Glu Leu Met Cys Ser Lys Gly
885 890 895
Ala His Arg Leu Lys His Asn Asn Gly Lys Leu Val Phe Asp Glu Asn
900 905 910
Glu Pro Gln Leu Gln Trp Leu Val Glu Cys Glu Thr Val Cys Glu Glu
915 920 925
Cys His Ser Val Ala Phe Ala Thr Glu Ser Cys Phe Leu Ala Pro Lys
930 935 940
Leu Tyr Gly Leu Lys Glu Ile Lys Cys Thr Lys Cys Asn His Ile Gly
945 950 955 960
Ser Gly Lys Leu Arg Ala Lys Gly His Ala Lys Glu Cys Leu Ser Tyr
965 970 975
Asp Val Leu Lys Arg Cys Phe Asn Asp Tyr Tyr Leu Leu Glu Asn Pro
980 985 990
Lys Glu Asn Phe Met Thr Lys Arg Lys Ser Leu Lys Arg Thr Leu Gln
995 1000 1005
Thr Gly Asn Glu Ile Ser Lys Pro Phe Thr Val Val Glu Lys Gln
1010 1015 1020
Leu Leu Arg Ile Leu Arg Pro Trp Lys Asp Met Thr Leu Arg Lys
1025 1030 1035
Gly Ile Gln Leu Ser Glu Gly Tyr Leu Leu Tyr Pro Tyr Asp Lys
1040 1045 1050
Arg His Pro Asn Pro Arg Pro Gln Glu Cys Leu Thr Glu Asn Pro
1055 1060 1065
Phe Trp Asp Asp Thr
1070
<210> 15
<211> 1071
<212> PRT
<213> 绵羊腺病毒7（Ovine adenovirus 7）
<400> 15
Met Ala Ser Lys Thr Ile Ile Lys Gln Arg Thr Thr Thr Tyr Ile Thr
1 5 10 15
Gly Ile Tyr Glu Asp Thr Tyr Ile Lys Ile Ile Tyr Tyr Lys Asn Phe
20 25 30
Glu Lys Ser Phe Tyr Asn Tyr Phe Ala Ile Gln Gly Leu Lys Leu Asn
35 40 45
Ser Phe Lys Lys Val Glu Asn Val Leu Asp Val Leu Lys Leu Cys Asp
50 55 60
Ser Asn Thr Pro Val Ser Leu Lys Ile Trp Lys Phe Asn Lys Arg Phe
65 70 75 80
Phe Lys Met Thr Glu Glu Ile Leu Asn Gly Asn Leu Leu Pro Ile Glu
85 90 95
Leu Leu Ile Leu Lys Gly Glu Ile Tyr Leu Ile Lys Thr Val Lys Gln
100 105 110
Gln Asn Lys Cys Glu Phe Cys Gly Thr Ile Tyr Ser Asn Ile His Asn
115 120 125
Cys Ser Ser Arg Arg Arg Asp Phe Tyr Tyr His Asn Ile His His Glu
130 135 140
Thr Lys Leu Trp Trp Glu Lys Ile Lys Phe Asn Pro Val Gly Ala Ile
145 150 155 160
Lys Ala Lys Arg Leu Phe Ile Val Tyr Asp Ile Glu Thr Tyr Thr Tyr
165 170 175
His Ser Leu Tyr Gly Lys Gln Leu Thr Pro Tyr Leu Leu Val Phe Lys
180 185 190
Leu Ile Gly Cys Lys Ser Leu Ile Lys Ile Ala Ser Lys Ile Ala Thr
195 200 205
Asp Ile Gly Tyr Glu Val Asn Arg Glu Cys Phe Val Met Leu Asn Lys
210 215 220
Lys Glu Asp Glu Ile Gly Ile Ala Phe Lys Lys Phe Arg Thr Glu Leu
225 230 235 240
Gln Ile Ser Val Ala Lys Lys Tyr Trp Ser Thr Phe Cys Glu Asn His
245 250 255
Gly Leu Glu Ser Asn Leu Ser Tyr Glu Asp Ile Met Val Leu Asn Lys
260 265 270
Glu Lys Lys Leu Lys Gln Cys Glu Pro Arg Tyr Ile Glu Leu Tyr Val
275 280 285
Val Gly His Asn Ile Cys Gly Phe Asp Glu Ile Ile Leu Ala Ser His
290 295 300
Val Leu Glu Gly Ile Asp Ser Glu Glu Leu Ser Met Phe Lys Leu Thr
305 310 315 320
Arg Ser Phe Met Pro Arg Ala Gly Lys Leu Leu Phe Asn Asp Ile Thr
325 330 335
Leu Ser Leu Pro Asn Pro Cys Phe Lys Lys Pro Ser His Thr Thr Tyr
340 345 350
Glu Arg Trp Lys Asn Gly Ile Ile Asn Phe Glu Asp Met Lys Trp Gln
355 360 365
Gly Ile Lys Phe Met Val Arg Asp Thr Phe Leu Leu Thr His Ser Ser
370 375 380
Leu Arg Asp Ala Ala Thr Ala Tyr Gln Leu Ser Val Ser Lys Gly Tyr
385 390 395 400
Cys Pro Tyr Arg Ala Ile Asn Asp Phe Phe Met Leu Gly Glu Tyr Glu
405 410 415
Lys Glu Asn Asn Gly Tyr Pro Val Gln Lys Tyr Trp Asn Ser Phe Glu
420 425 430
Glu Tyr Leu Gln Asn Lys Pro Lys His Asn Gln Lys Tyr Asn Leu Leu
435 440 445
Glu Glu Ala Lys Glu Tyr Cys Ile Asp Asp Val Ile Val Thr Ala Gln
450 455 460
Leu Val Glu Lys Leu Ile Glu Gly Tyr Gln Glu Phe Cys Thr Thr Ser
465 470 475 480
Leu Lys Leu Glu Cys Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser
485 490 495
Ser Asn Thr Gln Ala Leu Phe Lys Gln Ile Phe Tyr Asn Glu Glu Asp
500 505 510
His Pro Ser Glu Phe Leu Arg Asn Leu Glu Ala Pro Ser Glu Lys Met
515 520 525
Tyr Asp Phe Val Arg Met Ser Leu Arg Gly Gly Arg Cys Tyr Pro Ser
530 535 540
Phe Leu Gly Ile Phe Glu Glu Ala Ile Tyr Val Tyr Asp Ile Cys Gly
545 550 555 560
Met Tyr Ala Ser Ala Leu Thr His Pro Leu Pro Tyr Gly Lys Thr Leu
565 570 575
Asn Ala Phe Glu Ala Asn Ala Gln Ile Asp Tyr Phe Gln Glu Leu Leu
580 585 590
Gln Arg Lys Glu Lys Ile Asp Tyr Phe Asp Asn Ser Ile Lys Pro Met
595 600 605
Ile Val Val Ala Asp Cys Glu Pro Pro Ser Leu Asp Tyr Leu Asp Val
610 615 620
Leu Pro Pro Leu Cys Ser Lys Lys Ser Gly Lys Leu Cys Trp Ser Asn
625 630 635 640
Glu Thr Leu Ile Asn Glu Val Leu Thr Ser Ile Asp Leu Ile Thr Leu
645 650 655
His Asn Arg Gly Trp Lys Cys Lys Ile Ile Lys Ser Ser Glu Met Tyr
660 665 670
Ala Val Trp Ser Asp Trp Lys Pro Leu Cys Gln Lys Tyr Val Lys Val
675 680 685
Asn Ile Met Ala Lys Glu Lys Ala Ser Lys Ser Asn Asn Lys Ile Gln
690 695 700
Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala
705 710 715 720
Thr Arg Ile Asp Lys Lys Lys Val Val Phe Ala Glu Asn Ile Glu Glu
725 730 735
Lys Asp Lys Lys Arg Leu Glu Asn Gly Ser Ala Glu Ile Thr Ser Tyr
740 745 750
Thr Thr Val Ile Ser Lys Ser Leu Pro Lys Arg Ser Phe Glu Trp Asn
755 760 765
Gln Tyr Phe Ser Asn Leu Pro Glu Met Pro Pro Lys Asp Ser Lys Asp
770 775 780
Thr Asn Glu Asn Phe Asn Phe Pro Leu Phe Ile Gly Asn Gln Asp His
785 790 795 800
Val Thr Phe Lys Pro Ile Thr Phe Leu Ser Ala Asp Cys Asn Asp Leu
805 810 815
Ile Leu Thr Thr Ile Glu Asp Lys Glu Glu Trp Ile Lys Asn Asn Arg
820 825 830
Tyr Pro Thr Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe
835 840 845
Met Ser Glu Trp Ala Glu Ile Leu Tyr Gly Glu Asp Met Gly Lys Pro
850 855 860
Tyr Ile Glu Arg Glu Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu
865 870 875 880
Phe Leu Thr Glu Lys Gly His Gln Leu Met Leu Ser Lys Gly Leu His
885 890 895
Arg Leu Lys Lys Tyr Asn Ser Asn Leu Ile Phe Asp Glu Lys His Pro
900 905 910
Cys Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Asn Arg Cys Gly
915 920 925
Ala Glu Ala Phe Ser Ser Glu Thr Cys Ile Leu Ala Pro Lys Leu Tyr
930 935 940
Ala Leu Lys Asp Ile Thr Cys Lys Asn Cys Lys Phe Ile Gly Glu Gly
945 950 955 960
Lys Leu Arg Ala Lys Gly His Ala Lys Asn Cys Leu Asn Tyr Glu Ile
965 970 975
Leu Lys His Cys Phe Thr Asp Tyr Asn Leu Leu Glu Gln Pro Gln Lys
980 985 990
Glu Phe Gln Thr Ser Arg Lys Ser Leu Lys Lys Thr Leu Gln Thr Ala
995 1000 1005
Ser Gly Thr Asp Val Pro Phe Thr Val Val Glu Lys Gln Leu Thr
1010 1015 1020
Arg Ile Leu Arg Pro Trp Lys Asp Gln Thr Met Arg Lys Gly Ile
1025 1030 1035
Gln Trp Lys Lys Gly Tyr Leu Leu Tyr Pro Tyr Asp Lys Arg His
1040 1045 1050
Pro Asn Pro Arg Pro Gln Glu Pro Leu Thr Glu Asn Pro Phe Trp
1055 1060 1065
Glu Asn Phe
1070
<210> 16
<211> 1079
<212> PRT
<213> 鸭腺病毒A（Duck adenovirus A）
<400> 16
Met Ala Gln Ser Ser Thr Val Ser Arg Leu Arg Ser Thr Lys Tyr Ile
1 5 10 15
Cys Gly Ser Leu Asn Gly Glu Asn Val Lys Ile Thr Tyr Phe Thr Asp
20 25 30
Ile Cys Lys Ala Leu Asn Asn Ile Leu Ala Leu Asn Arg Ile Glu Lys
35 40 45
Lys Ile Phe Thr Ala Pro Asn Leu Gly Asn Ile Ile Lys Ile Phe Pro
50 55 60
Gln Asn Lys Gln Pro Thr His Ile Thr Leu Tyr Lys Leu Glu Lys Gly
65 70 75 80
Leu Ile Lys Thr Glu Glu Ile Phe Ser Gly Gly Asp Ile Glu Pro Leu
85 90 95
Leu Ile Leu Asn His Lys Ser Glu Leu Phe Ile Ile Lys Thr Tyr Val
100 105 110
Thr Gln Glu Lys Cys Gln Thr Cys Gly Thr Leu Tyr Ser Thr Asn His
115 120 125
Asn Cys Asn Val Arg Lys Thr Ala Tyr Phe His His Ile Val Asn Lys
130 135 140
Asp Thr Arg Thr Trp Trp Gln Pro Ile Lys Phe His Pro Val Gly Cys
145 150 155 160
Val Glu Thr Lys Arg Leu Tyr Val Val Tyr Asp Ile Glu Thr Tyr Thr
165 170 175
Tyr His Ser Lys Tyr Gly Lys Gln Leu Val Pro Tyr Leu Leu Val Phe
180 185 190
Gln Leu Phe Gly Glu Glu Thr Leu Ile Asp Leu Ala Lys Ala Glu Ala
195 200 205
Glu Met Val Gly Tyr Thr Ala Tyr Asp Gly Cys Phe Tyr Ile Leu Asn
210 215 220
Lys Asp Pro Glu Val Val Gly Gln Ser Phe Lys Leu Phe Arg Ser Asn
225 230 235 240
Leu Gln Asp Lys Val Thr Asn Leu Ala Trp Glu Arg Phe Cys Glu Asp
245 250 255
Asn Ala Leu Asp Pro Tyr Ser Arg Ile Thr Ala Lys Gln Leu Gln Lys
260 265 270
Leu Asn Lys Ser Gln Lys Leu Asn Lys Thr Ala Glu Pro Gln Phe Tyr
275 280 285
Glu Ile Ile Ile Val Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val
290 295 300
Leu Ala Ser His Ile Leu Asp Asn Val Lys Asp Lys Asp Tyr Phe Val
305 310 315 320
Met Phe Asn Ile Thr Arg Asn Phe Leu Pro Arg Ala Gly Lys Leu Leu
325 330 335
Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Gln Tyr Lys Lys Pro
340 345 350
Ser Arg Gly Thr Phe Asp Arg Trp Gln Asn Gly Met Leu Asp Lys Gln
355 360 365
Asp Leu Lys Trp Gln Gly Val Lys Phe Met Val Arg Asp Thr Tyr Leu
370 375 380
Leu Thr His Thr Ser Leu Arg Asn Ala Ala Thr Ala Tyr Gln Leu Pro
385 390 395 400
Ile Ser Lys Gly Cys Cys Pro Tyr Glu Ala Val Asn Glu Tyr Leu Met
405 410 415
Thr Gly Asn Tyr Glu Gln Glu Thr Asn Gly Tyr Pro Thr Leu Lys Tyr
420 425 430
Trp Asn Asn Ala Asp Glu Tyr His Gln Asn Lys Ile Lys Gly Pro Tyr
435 440 445
Asp Ile Leu Lys Glu Ala Leu Ile Tyr Cys Ile Ala Asp Val Lys Val
450 455 460
Thr Ser Gln Leu Thr Arg Lys Leu Ile Glu Gly Tyr Gln Ser Phe Cys
465 470 475 480
Asn Asp Gln Ile Lys Leu Thr Cys Gln Phe His Ile Phe Gln Arg Pro
485 490 495
Thr Ile Ser Ser Asn Thr His Ala Leu Phe Lys Gln Ile Leu Tyr Arg
500 505 510
Ala Glu Lys Gly Gln Thr Glu His Leu Pro Gly Leu Gln Ala Pro Ser
515 520 525
Glu Lys Met Tyr Asp His Ile Arg Lys Ser Val Arg Gly Gly Arg Cys
530 535 540
Tyr Pro Ser Tyr Leu Gly Val Tyr Glu Gly Pro Ile Tyr Val Tyr Asp
545 550 555 560
Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Phe Gly
565 570 575
Arg Thr Glu Asp Pro Leu Thr Ala Ser Ile Ser Ile Lys Thr Phe Gln
580 585 590
Asp Lys Leu Asp Ser Pro Ala Lys Leu Ser Tyr Phe Gly Glu Ser Ile
595 600 605
Lys Pro Met Ile Val Tyr Ala Asp Cys Tyr Pro Pro Pro Leu Glu His
610 615 620
Val Asp Val Leu Pro Pro Leu Cys Ser Arg Lys Ser Gly Arg Leu Cys
625 630 635 640
Trp Thr Asn Glu Pro Leu Leu Gly Glu Val Val Thr Thr Ile Asp Leu
645 650 655
Ile Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Leu Thr Ser Glu
660 665 670
Gln Leu Tyr Ala Val Trp Pro Glu Trp Lys Cys Ile Thr Lys Glu Tyr
675 680 685
Val Ser Ile Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Asp Lys Asn
690 695 700
Met Thr Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly
705 710 715 720
Ser Phe Ala Thr Arg Leu Asp Asn Lys Lys Val Val Phe Ala Asn Ser
725 730 735
Met Glu Lys Gly Asp Met Glu Arg Ile Ala Asn Gly Lys Ala Thr Ile
740 745 750
Thr Ala Gln Thr Thr Val Ile Asn Thr Cys Leu Pro Lys Lys Asp Thr
755 760 765
Thr Ser Trp Glu Arg Phe Phe Ser Asn Leu Pro Gln Thr Thr Ala Leu
770 775 780
Pro Val Ala Pro Ser Thr Glu Asn Glu Gly Asn Asp Ile Asn Pro Lys
785 790 795 800
Ser Phe Ile Glu Gly Ala Gly His Val Thr Phe Lys Pro Ile Thr His
805 810 815
Leu Thr Ala Ala Cys Asp Asp Leu Ile Leu Ser Ile Ile Glu Glu Arg
820 825 830
Ser Glu Trp Ile Glu Asn Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe
835 840 845
Val Leu Ala Trp Thr Arg Ala Phe Thr Ser Glu Trp Ala Ser Phe Leu
850 855 860
Phe Glu Asp Asp Trp Gly Ser Asn Ile Glu Asn Arg Ser Leu Lys Val
865 870 875 880
Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gln His Gly His Glu
885 890 895
Leu Met Ile Thr Lys Gly Lys His Arg Ile Lys Gly Tyr Gly Thr Ala
900 905 910
Leu Thr Phe Asp Pro His Asn Pro Asn Leu Thr Trp Leu Val Glu Cys
915 920 925
Glu Thr Val Cys Pro Leu Cys Lys Lys Ile Ala Tyr Ser Thr Glu Ser
930 935 940
Val Tyr Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ile Tyr Cys Glu
945 950 955 960
His Cys Asp Val Tyr Ser Ala Gly Lys Leu Arg Ala Lys Gly His Ala
965 970 975
Lys Asp Cys Ile Asn Tyr Glu Thr Leu Lys Lys Cys Phe Ile Asp His
980 985 990
Asp Leu Leu Thr Gly Arg Asp Leu Gln Tyr Lys Thr Gln Arg Lys Met
995 1000 1005
Leu Lys Arg Thr Leu Thr Ala Gly Asn Thr Thr Asn Arg Pro Phe
1010 1015 1020
Thr Val Val Glu Lys Gln Leu Thr Arg Thr Leu Arg Pro Trp Ala
1025 1030 1035
Asp Met Thr Met Trp Ala Val Thr Gln Ser Asn Asn Gly Tyr Leu
1040 1045 1050
Leu Phe Pro Tyr Asp Lys Lys His Pro Asn Pro Arg Gln Gln Glu
1055 1060 1065
Leu Leu Thr Glu Asn Pro Phe Trp Glu Ser Thr
1070 1075
<210> 17
<211> 1079
<212> PRT
<213> 鸭腺病毒1（Duck adenovirus 1）
<400> 17
Met Ala Gln Ser Ser Thr Val Ser Arg Leu Arg Ser Thr Lys Tyr Ile
1 5 10 15
Cys Gly Ser Leu Asn Gly Glu Asn Val Lys Ile Thr Tyr Phe Thr Asp
20 25 30
Ile Cys Lys Ala Leu Asn Asn Ile Leu Ala Leu Asn Arg Ile Glu Lys
35 40 45
Lys Ile Phe Thr Ala Pro Asn Leu Gly Asn Ile Ile Lys Ile Phe Pro
50 55 60
Gln Asn Lys Gln Pro Thr His Ile Thr Leu Tyr Lys Leu Glu Lys Gly
65 70 75 80
Leu Ile Lys Thr Glu Glu Ile Phe Ser Gly Gly Asp Ile Glu Pro Leu
85 90 95
Leu Ile Leu Asn His Lys Ser Glu Leu Phe Ile Ile Lys Thr Tyr Val
100 105 110
Thr Gln Glu Lys Cys Gln Thr Cys Gly Thr Leu Tyr Ser Thr Asn His
115 120 125
Asn Cys Asn Val Arg Lys Thr Ala Tyr Phe His His Ile Val Asn Lys
130 135 140
Asp Thr Arg Thr Trp Trp Gln Pro Ile Lys Phe His Pro Val Gly Cys
145 150 155 160
Val Glu Thr Lys Arg Leu Tyr Val Val Tyr Asp Ile Glu Thr Tyr Thr
165 170 175
Tyr His Ser Lys Tyr Gly Lys Gln Leu Val Pro Tyr Leu Leu Val Phe
180 185 190
Gln Leu Phe Gly Glu Glu Thr Leu Ile Asp Leu Ala Lys Ala Glu Ala
195 200 205
Glu Met Val Gly Tyr Thr Ala Tyr Asp Gly Cys Phe Tyr Ile Leu Asn
210 215 220
Lys Asp Pro Glu Val Val Gly Gln Ser Phe Lys Leu Phe Arg Ser Asn
225 230 235 240
Leu Gln Asp Lys Val Thr Asn Leu Ala Trp Glu Arg Phe Cys Glu Asp
245 250 255
Asn Ala Leu Asp Pro Tyr Ser Arg Ile Thr Ala Lys Gln Leu Gln Lys
260 265 270
Leu Asn Lys Ser Gln Lys Leu Asn Lys Thr Ala Glu Pro Gln Phe Tyr
275 280 285
Glu Ile Ile Ile Val Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val
290 295 300
Leu Ala Ser His Ile Leu Asp Asn Val Lys Asp Lys Asp Tyr Phe Val
305 310 315 320
Met Phe Asn Ile Thr Arg Asn Phe Leu Pro Arg Ala Gly Lys Leu Leu
325 330 335
Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Gln Tyr Lys Lys Pro
340 345 350
Ser Arg Gly Thr Phe Asp Arg Trp Gln Asn Gly Met Leu Asp Lys Gln
355 360 365
Asp Leu Lys Trp Gln Gly Val Lys Phe Met Val Arg Asp Thr Tyr Leu
370 375 380
Leu Thr His Thr Ser Leu Arg Asn Ala Ala Thr Ala Tyr Gln Leu Pro
385 390 395 400
Ile Ser Lys Gly Cys Cys Pro Tyr Glu Ala Val Asn Glu Tyr Leu Met
405 410 415
Thr Gly Asn Tyr Glu Gln Glu Thr Asn Gly Tyr Pro Thr Leu Lys Tyr
420 425 430
Trp Asn Asn Ala Asp Glu Tyr His Gln Asn Lys Ile Lys Gly Pro Tyr
435 440 445
Asp Ile Leu Lys Glu Ala Leu Ile Tyr Cys Ile Ala Asp Val Lys Val
450 455 460
Thr Ser Gln Leu Thr Arg Lys Leu Ile Glu Gly Tyr Gln Ser Phe Cys
465 470 475 480
Asn Asp Gln Ile Lys Leu Thr Cys Gln Phe His Ile Phe Gln Arg Pro
485 490 495
Thr Ile Ser Ser Asn Thr His Ala Leu Phe Lys Gln Ile Leu Tyr Arg
500 505 510
Ala Glu Lys Gly Gln Thr Glu His Leu Pro Gly Leu Gln Ala Pro Ser
515 520 525
Glu Lys Met Tyr Asp His Ile Arg Lys Ser Val Arg Gly Gly Arg Cys
530 535 540
Tyr Pro Ser Tyr Leu Gly Val Tyr Glu Gly Pro Ile Tyr Val Tyr Asp
545 550 555 560
Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Phe Gly
565 570 575
Arg Thr Glu Asp Pro Leu Thr Ala Ser Ile Ser Ile Lys Thr Phe Gln
580 585 590
Asp Lys Leu Asp Ser Pro Ala Lys Leu Ser Tyr Phe Gly Glu Ser Ile
595 600 605
Lys Pro Met Ile Val Tyr Ala Asp Cys Tyr Pro Pro Pro Leu Glu His
610 615 620
Val Asp Val Leu Pro Pro Leu Cys Ser Arg Lys Ser Gly Arg Leu Cys
625 630 635 640
Trp Thr Asn Glu Pro Leu Leu Gly Glu Val Val Thr Thr Ile Asp Leu
645 650 655
Ile Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Leu Thr Ser Glu
660 665 670
Gln Leu Tyr Ala Val Trp Pro Glu Trp Lys Cys Ile Thr Lys Glu Tyr
675 680 685
Val Ser Ile Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Asp Lys Asn
690 695 700
Met Thr Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly
705 710 715 720
Ser Phe Ala Thr Arg Leu Asp Asn Lys Lys Val Val Phe Ala Asn Ser
725 730 735
Met Glu Lys Gly Asp Met Glu Arg Ile Ala Asn Gly Lys Ala Thr Ile
740 745 750
Thr Ala Gln Thr Thr Val Ile Asn Thr Cys Leu Pro Lys Lys Asp Thr
755 760 765
Thr Ser Trp Glu Arg Phe Phe Ser Asn Leu Pro Gln Thr Thr Ala Leu
770 775 780
Pro Val Ala Pro Ser Thr Glu Asn Glu Gly Asn Asp Ile Asn Pro Lys
785 790 795 800
Ser Phe Ile Glu Gly Ala Gly His Val Thr Phe Lys Pro Ile Thr His
805 810 815
Leu Thr Ala Ala Cys Asp Asp Leu Ile Leu Ser Ile Ile Glu Glu Arg
820 825 830
Ser Glu Trp Ile Glu Asn Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe
835 840 845
Val Leu Ala Trp Thr Arg Ala Phe Thr Ser Glu Trp Ala Ser Phe Leu
850 855 860
Phe Glu Asp Asp Trp Gly Ser Asn Ile Glu Asn Arg Ser Leu Lys Val
865 870 875 880
Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gln His Gly His Glu
885 890 895
Leu Met Ile Thr Lys Gly Lys His Arg Ile Lys Gly Tyr Gly Thr Ala
900 905 910
Leu Thr Phe Asp Pro His Asn Pro Asn Leu Thr Trp Leu Val Glu Cys
915 920 925
Glu Thr Val Cys Pro Leu Cys Lys Lys Ile Ala Tyr Ser Thr Glu Ser
930 935 940
Val Tyr Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ile Tyr Cys Glu
945 950 955 960
His Cys Asp Val Tyr Ser Ala Gly Lys Leu Arg Ala Lys Gly His Ala
965 970 975
Lys Asp Cys Ile Asn Tyr Glu Thr Leu Lys Lys Cys Phe Ile Asp His
980 985 990
Asp Leu Leu Thr Gly Arg Asp Leu Gln Tyr Lys Thr Gln Arg Lys Met
995 1000 1005
Leu Lys Arg Thr Leu Thr Ala Gly Asn Thr Thr Asn Arg Pro Phe
1010 1015 1020
Thr Val Val Glu Lys Gln Leu Thr Arg Thr Leu Arg Pro Trp Ala
1025 1030 1035
Asp Met Thr Met Trp Ala Val Thr Gln Ser Asn Asn Gly Tyr Leu
1040 1045 1050
Leu Phe Pro Tyr Asp Lys Lys His Pro Asn Pro Arg Gln Gln Glu
1055 1060 1065
Leu Leu Thr Glu Asn Pro Phe Trp Glu Ser Thr
1070 1075
<210> 18
<211> 1202
<212> PRT
<213> 小鼠腺病毒3（Murine adenovirus 3）
<400> 18
Met Ala Gln Ile Ile Ser Ser Val Gly Thr Ser Ser Leu His Pro Glu
1 5 10 15
Ser Thr Asn Thr Asn Leu Asp Ser Ser Ser Leu Thr Gly Ser Asn Gln
20 25 30
Ile Ala Ala Gly Thr Pro Ser Asn Ala Glu Ser Gln Pro Ser Ser Arg
35 40 45
Thr Pro Ser Arg Gly Arg Pro Arg Lys Ala Thr Val Ser Pro Leu Lys
50 55 60
Lys Arg Lys Ser Lys Val Ile Ala Lys Ser His Lys Thr Leu Lys Ala
65 70 75 80
Pro Cys Pro Asn Gly Gln Tyr Met Ala Val Gly Tyr Phe Thr Ser Phe
85 90 95
Leu Gln Pro Phe Thr Asn Leu Leu Cys Leu Gln Asp Gly Glu Ser Phe
100 105 110
Pro His Pro Asn Leu Cys Asp Leu Phe Lys Thr Ser Asp Ala Ser His
115 120 125
Lys Lys Pro Thr Val Arg Gln Leu Thr Asn Ala Leu Gln Lys Glu Glu
130 135 140
Trp Pro Ala Pro Val Thr His Val Trp Phe Asp Gly Lys Tyr Leu Arg
145 150 155 160
Lys Ser Asn Trp Pro Asn Leu Lys Ser Pro Ala Gly Cys Tyr Pro Ser
165 170 175
Glu Pro Lys Gln Gly Ser Leu Glu Glu Lys Arg Trp Ser Trp Gln Lys
180 185 190
Thr Arg Pro His Leu Thr Phe Leu Glu Ile Gln Lys Gly Thr Gly Arg
195 200 205
Gly Pro Glu Asn His Gln Met Gly Leu Tyr Leu Val Asp Tyr Ile Tyr
210 215 220
Pro Cys Glu Arg Cys Glu Asp Cys Gly Thr Ile Phe Arg Phe Lys His
225 230 235 240
Thr Cys Asn Ala Arg Arg Arg Ser Tyr Phe Phe His Asn Leu Gln Pro
245 250 255
Leu Ser Arg Arg Trp Trp Ser Lys Ile Ser Phe Ser Pro Leu Gly Ser
260 265 270
Ile Pro Ser Thr Gln Arg Leu Phe Ile Ile Tyr Asp Leu Glu Thr Tyr
275 280 285
Cys Trp His Gly Ser Cys Gly Lys Gln Leu Val Pro Phe Met Ile Val
290 295 300
Met Gln Phe Trp Gly Glu Ser Thr Leu Cys Ser Thr Ala Tyr Lys Val
305 310 315 320
Ala Lys Asn Thr Gly Tyr Ile Asn Tyr Gly Ser Asp Pro Tyr Leu Phe
325 330 335
Tyr Ala Ile Asn Pro Gln Lys Gln Ala Ile Gly Arg Gln Phe Arg Asn
340 345 350
Phe Arg Asp Arg Leu Gln Glu Thr Phe Ala Arg Glu Phe Trp Glu Arg
355 360 365
Asn Met Thr Pro Glu Met Lys Lys Tyr Ile Ala Ser Leu Pro Leu Gly
370 375 380
Leu Leu Asp Leu Thr Pro Gln Lys Leu Pro Glu Ala Pro Gln Leu Thr
385 390 395 400
Pro Lys Pro Gln Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Asn
405 410 415
Gly Phe Asp Glu Ile Val Val Ala Ala Gln Val Leu Asn Asn Arg Ile
420 425 430
Asn Phe Pro Pro Pro Ile Glu Val His Arg His Phe Met Pro Arg Asn
435 440 445
Gly Arg Ile Leu Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Leu
450 455 460
Tyr Glu Ala Arg Glu Asp Phe Gly Ser Trp Glu Glu Gly Arg Leu Ser
465 470 475 480
Ile Ser Asp Ser Lys Ile Gln Tyr Val Lys Phe Met Val Arg Asp Thr
485 490 495
Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala Glu Ala Tyr Ala
500 505 510
Leu Pro Val Glu Lys Gly Leu Cys Pro Tyr Ala Ala Ile Asn Asp Phe
515 520 525
Tyr Met Thr Gly Lys Tyr Glu Ser Asp Ser Ser Asp Gly Phe Pro Ser
530 535 540
Arg Lys Tyr Trp Ser Ser Asp Glu Glu Phe Asn Glu Ala Phe Ala Gln
545 550 555 560
Trp Arg Thr Glu Gln Met His Asp Arg Thr Ser Phe Glu Pro Leu Gln
565 570 575
Tyr Asn Leu Ile Glu Gln Thr Leu Lys Tyr Cys Ile Lys Asp Val Gln
580 585 590
Val Thr Thr Lys Leu Val Cys Lys Leu Phe Ser Ser Tyr Lys Lys Phe
595 600 605
Ile Gln Thr Glu Val Gln Leu Pro Lys Cys Ser Phe Asn Ile Phe Gln
610 615 620
Arg Pro Thr Ile Ser Ala Asn Ser His Ala Ile Phe Lys Gln Thr Leu
625 630 635 640
Tyr Thr Glu Gln Arg Pro Gly Lys Pro Asn Phe His Asn Cys Leu Leu
645 650 655
Ala Pro Ser Arg Glu Met Tyr Asp Phe Val Arg Gln Ser Ile Arg Gly
660 665 670
Gly Arg Cys Tyr Pro Thr Tyr Leu Gly Glu Val Thr Glu Pro Ile Tyr
675 680 685
Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met
690 695 700
Pro Thr Gly Trp Pro Leu Asp Pro Lys Ala Arg Ala Glu Ala Leu Glu
705 710 715 720
Asn Trp Gln Ile Lys Leu Ser Gln Arg Glu Lys Leu Ser Tyr Phe Asp
725 730 735
Ser His Leu Leu His Gly Ile Val Leu Ile Asp Ala Asp Pro Pro Ser
740 745 750
Glu Lys Asp Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly
755 760 765
Arg Leu Cys Trp Thr Asn Glu Thr Leu Arg Gly Glu Val Ala Thr Thr
770 775 780
Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys Val Lys Ile Leu
785 790 795 800
Pro Glu Asp Arg Thr Thr Leu Phe Pro Gln Met Lys Cys Leu Val Arg
805 810 815
Thr Tyr Val Thr Ile Asn Ile Ala Ala Lys Glu Arg Ala Asp Lys Gln
820 825 830
Lys Asn Met Val Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu
835 840 845
Tyr Gly Ser Phe Ala Thr Arg Gln Asp Asn Lys Cys Thr Leu Phe Thr
850 855 860
Ser Gln Leu Gln Ala Gly Val Ile Lys Asp Ile Cys Glu Gly Glu Gln
865 870 875 880
Lys Val Lys Ala Ile His Val Val Glu Thr Asp Asn Leu Ser Ala Glu
885 890 895
Ile Leu Thr Pro Phe Lys Ala Leu Tyr Gln Pro Ala His Lys Gln Ala
900 905 910
Arg Gln Lys Glu Pro Ser Thr Pro Met Met Ala Glu Gly Arg Pro Ser
915 920 925
Ser Phe Tyr Ser His Glu Lys Thr Leu Asn His Ala Leu Ser Asn Tyr
930 935 940
Lys Pro Ile Thr Phe Leu Glu Ala Glu Ala Asp Asp Leu Thr Leu Val
945 950 955 960
Thr Leu Glu Arg Ser Ser Pro Leu Val Gly Asn Asp Arg Tyr Ala Ser
965 970 975
His Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Gly Phe Met Ser Glu
980 985 990
Trp Ser Glu Ile Leu Tyr Glu Ser Asp Arg Gly Ile Ala Leu Glu Arg
995 1000 1005
Arg Leu Asn Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val
1010 1015 1020
Thr Glu His Gly Arg Ile Leu Met Glu Thr Arg Gly Gln His Arg
1025 1030 1035
Leu Lys Lys Asn Gly Gly Lys Leu Val Phe Asn Pro Asn Ser Pro
1040 1045 1050
Gln Leu Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Lys Arg Cys
1055 1060 1065
Asn Ser Asp Ala Phe Ser Pro Arg Thr Ile Phe Leu Ala Pro Lys
1070 1075 1080
Leu Tyr Ala Leu Gln Lys Leu Ile Cys Gln Asn Cys Gly Glu Glu
1085 1090 1095
Gly Pro Gly Lys Leu Arg Ala Lys Gly His Ala Val Thr Ser Leu
1100 1105 1110
Ser Tyr Asp Met Leu His Ala Cys Phe Glu Ala Tyr Arg Leu Lys
1115 1120 1125
Asp Asn Glu Pro Asn Phe Tyr Thr Ser Arg Gln Ser Leu Arg Arg
1130 1135 1140
Thr Leu Ile Ser Met Asn Gln Gln Glu Ser Ala Phe Thr Val Thr
1145 1150 1155
Glu Thr Thr Leu Thr Arg Ser Leu Arg Pro Trp Gln Ser Pro Thr
1160 1165 1170
Leu Ala Ser Leu Gly Asp Gly Arg Leu Val Pro Tyr Ser Ser Ala
1175 1180 1185
Arg Pro Asn Pro Arg Asn Arg Glu Thr Thr Trp Ile Ala Ile
1190 1195 1200
<210> 19
<211> 1214
<212> PRT
<213> 小鼠腺病毒A（Murine adenovirus A）
<400> 19
Met Ala Gln Ile Val Pro Ala Phe Gly Ser Ser Gly Ile His Arg Lys
1 5 10 15
Ser Thr Asp Thr Asn Leu Asn Pro Ser Ser Ile Thr Gly Gly Asp Ser
20 25 30
Ser Ser Ser Thr Thr Thr Pro Asp Ala Asp Ala Gln Ser Ser Ser Arg
35 40 45
Thr Pro Ala Arg Gly Arg Pro Arg Lys Lys Ala Thr Val Ser Ser Pro
50 55 60
Lys Gln Lys Gln Gln Ser Lys Val Leu Gln Lys Ala His Lys Thr Leu
65 70 75 80
Arg Ala Ala Cys Pro Arg Gly Asp His Met Val Ile Gly Tyr Phe Thr
85 90 95
Ser Tyr Val Val Pro Phe Thr Asn Leu Leu Cys Leu Gln Arg Cys Gly
100 105 110
Pro Phe Pro His Pro Phe Leu Leu Asp Ala Phe Lys Ala Ala Asp Ile
115 120 125
Gly His Lys Ser Ile Ser Val Thr Ser Leu Thr Arg Leu Leu Gln Lys
130 135 140
Glu Glu Trp Pro Ala Pro Val Asn Tyr Val Trp Tyr Asp Gly Leu Tyr
145 150 155 160
Ile Arg Gln Ser Lys Trp Pro Gly Leu Lys Gly His Ala Gly Arg Tyr
165 170 175
Pro Gln Val Asp Lys Asp Ala Ser Tyr Glu Glu Lys Arg Trp Cys Trp
180 185 190
Gln Asn Tyr Arg Pro Glu Leu Thr Phe Leu His Ile Gln Lys Gly Leu
195 200 205
Gly Thr Lys Gly Ser Asn Tyr His Lys Ile Gly Leu Tyr Leu Val Asp
210 215 220
Thr Met His Pro Cys Gln Arg Cys Glu Asp Cys Gly Ser Phe Phe Arg
225 230 235 240
Phe Lys His Thr Cys Asn Ala Arg Arg Arg Ser Phe Phe Phe His Asn
245 250 255
Leu Lys Pro Leu Ser Arg Gln Trp Trp Thr Lys Ile Ser Phe Thr Pro
260 265 270
Leu Gly Ser Ile Pro Thr Thr Lys Arg Leu Phe Ile Ile Tyr Asp Leu
275 280 285
Glu Thr Tyr Cys Trp His Gly Ser Cys Gly Lys Gln Leu Val Pro Phe
290 295 300
Met Leu Val Met Glu Leu Tyr Gly Asp Met Phe Leu Cys Ala Lys Ala
305 310 315 320
His Ser Ile Ala Lys Gln Met Gly Tyr Ser Glu His His Leu Arg Pro
325 330 335
Tyr Ile Leu Trp Ser Ile Asn Pro Gln Lys Glu Ala Ile Gly Arg Gln
340 345 350
Phe Arg Arg Phe Arg Asp Arg Leu Gln Glu Ala Phe Ala Glu Glu Leu
355 360 365
Trp Gln Asn Asn Ile Tyr Pro Glu Leu Gln Thr Tyr Ile Asp Ser Leu
370 375 380
Pro Leu Gly Leu Leu Asp Leu Thr Pro Glu Arg Leu Glu Gln Glu Ala
385 390 395 400
Pro Pro Leu Lys Asn Thr Pro Lys Phe Ile Glu Val Tyr Val Val Gly
405 410 415
His Asn Ile Asn Gly Phe Asp Glu Ile Val Val Ala Ala Gln Val Leu
420 425 430
Asn Asn Arg Val Asn Phe Pro Pro Pro Leu Arg Val His Arg His Phe
435 440 445
Met Pro Arg Asn Gly Arg Ile Leu Phe Asn Asp Ile Thr Phe Ser Leu
450 455 460
Pro Asn Pro Arg Tyr Lys Lys Arg Thr Asp Phe Glu Gln Trp Glu Gln
465 470 475 480
Gly Cys Leu Thr Thr Ser Asp Ser Lys Ile Gln Tyr Val Lys Phe Met
485 490 495
Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala
500 505 510
Glu Ala Tyr Ser Leu Pro Leu Glu Lys Gly Val Cys Pro Tyr Ala Ala
515 520 525
Val Asn Asp Phe Tyr Met Thr Gly Arg Tyr Asp Thr Ile Asn Ile Phe
530 535 540
Asp Gly Phe Pro His Arg Lys Tyr Trp Asn Ser Glu Ala Glu Tyr Glu
545 550 555 560
Glu Gly Leu Gln Glu Trp Lys Lys Glu Lys Glu Glu Leu Arg Lys Arg
565 570 575
Cys Pro Asp Arg Val Cys Pro Ile Lys Tyr Asn Leu Ile Glu His Thr
580 585 590
Leu Lys Tyr Cys Ile Gln Asp Val Thr Val Thr Thr Lys Leu Val Cys
595 600 605
Lys Leu Leu Asp Ser Tyr His His Phe Ile Gln Asn Ala Val Gly Leu
610 615 620
Pro Lys Cys Leu Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser Ala Asn
625 630 635 640
Ser His Ala Ile Phe Lys Gln Thr Leu Tyr Ser Glu Leu Arg Pro Glu
645 650 655
Lys Pro Asn Phe Asp Asp Val Leu Leu Ala Pro Ser Arg Glu Met Tyr
660 665 670
Asp Phe Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Val
675 680 685
Leu Gly Glu Leu Lys Glu Pro Ile Tyr Val Tyr Asp Ile Cys Gly Met
690 695 700
Tyr Ala Ser Ala Leu Thr His Pro Met Pro Ser Gly Trp Pro Leu Glu
705 710 715 720
Pro Lys Ala Arg Ala Glu Ala Leu Ala Asp Trp Thr Lys His Leu Ser
725 730 735
Asn Ser Ala Pro Ile Ser Tyr Phe Asn Thr Cys Leu Leu His Gly Ile
740 745 750
Val Leu Ile Asp Ala Asp Pro Pro Cys Glu Thr Gln Leu Asp Val Leu
755 760 765
Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu
770 775 780
Pro Leu Arg Gly Glu Ile Thr Thr Thr Ile Asp Val Ile Thr Leu His
785 790 795 800
Asn Arg Gly Trp Lys Val Asn Ile Leu Pro Glu Ala Leu Thr Thr Leu
805 810 815
Phe Pro His Met Lys Cys Leu Val Arg Lys Tyr Val Thr Ile Asn Ile
820 825 830
Thr Ala Lys Glu Lys Ala Asp Arg Gln Lys Asn Met Val Met Arg Ser
835 840 845
Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg
850 855 860
Gln Asp Asn Lys Ser Thr Val Phe Ala Ser Gln Leu Tyr Pro Gly Thr
865 870 875 880
Ile Lys Glu Ile Cys Thr Gly Arg Gln Lys Ile Lys Ala Leu His Val
885 890 895
Val Glu Thr Asp Asn Leu Cys Ala Glu Ile Leu Thr Glu Phe Lys Thr
900 905 910
Ile Tyr Gln Pro Ser Cys Glu Asn Thr Arg Pro Pro His Val Ala Asp
915 920 925
Ser Ala Glu Leu Ser Pro Arg Gly Ser His Pro Ala Pro Phe Tyr Arg
930 935 940
Glu Gln Gln Val Val Asp His Ala Leu Phe Asn Phe Lys Pro Ile Lys
945 950 955 960
Phe Leu Asp Ala Glu Ala Asp Asp Leu Thr Leu Val Thr Leu Glu His
965 970 975
Ser Asn Pro Leu Val Asp Asn Asp Arg Tyr Ala Ser His Leu Ala Ser
980 985 990
Phe Val Leu Ala Trp Thr Arg Gly Phe Met Ser Glu Trp Ser Asp Ile
995 1000 1005
Leu Tyr Glu Ser Asp Arg Gly Leu Gln Leu Glu Lys Arg Leu Ile
1010 1015 1020
Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala
1025 1030 1035
Gly Arg Asn Leu Met Glu Ser Arg Gly Lys His Arg Leu Lys Lys
1040 1045 1050
Asn Gly Gly Lys Leu Val Phe Asn Pro Glu Lys Pro Ser Leu Thr
1055 1060 1065
Trp Leu Val Glu Cys Glu Thr Gln Cys Lys Tyr Cys Gly Ser Asp
1070 1075 1080
Ala Phe Ser Pro Arg Thr Val Phe Leu Ala Pro Lys Leu Tyr Ala
1085 1090 1095
Leu Gln Lys Leu Val Cys Pro Thr Cys Gly Gln Glu Gly Ala Gly
1100 1105 1110
Lys Leu Arg Ala Lys Gly His Ala Val Ala Ser Leu Ser Tyr Asp
1115 1120 1125
Ile Leu Leu Ala Cys Tyr Glu Ala Tyr Arg Leu Asn Glu Ser Asp
1130 1135 1140
Pro Asn Phe Tyr Thr Ser Arg Gln Ser Leu Lys Arg Thr Leu Val
1145 1150 1155
Asn Met Asn Lys Gln Glu Ser Ala Phe Thr Val Thr Glu Thr Val
1160 1165 1170
Leu Thr Arg Ser Leu Arg Pro Trp Gln Asn Pro Thr Leu Ala Leu
1175 1180 1185
Leu Glu Asp Gly Arg Leu Ile Pro Tyr Ser Thr Ala His Pro Asn
1190 1195 1200
Pro Arg Asn Arg Glu Thr Thr Trp Ile Ala Leu
1205 1210
<210> 20
<211> 1023
<212> PRT
<213> 牛腺病毒3（Bovine adenovirus 3）
<400> 20
Met Cys Val Tyr Lys Thr Tyr Lys Gly Lys Leu Lys Ile Thr Ser Ile
1 5 10 15
Pro Ala Arg Ala Asp Arg Pro Arg Leu Pro Phe Pro Leu Asn Phe Leu
20 25 30
Ile His Lys Arg Lys Leu Tyr Leu Ile Asp Thr Ile Ala Glu Val Gln
35 40 45
Arg Cys Ala Asp Cys Gly Ser Tyr Phe Lys Gln Thr His Thr Cys Ser
50 55 60
Thr Arg Arg Arg Asp Phe Tyr Phe His His Ile Asn Thr Gln Ser Ser
65 70 75 80
Asp Trp Trp Glu Glu Ile Lys Phe Phe Pro Trp Ala Ala His Pro Asp
85 90 95
Thr Arg Arg Leu Phe Val Val Tyr Asp Val Glu Thr Tyr Thr Trp His
100 105 110
Gly Ser Phe Gly Lys Gln Leu Met Pro Phe Met Leu Val Phe Thr Leu
115 120 125
Phe Gly Asp Ala Gln Leu Cys Glu Gln Ala Val Asn Ile Ala Lys Lys
130 135 140
Gln Lys Trp Ser Ser Trp Pro Lys Gln Ala Asn Thr Phe Tyr Tyr Leu
145 150 155 160
Asn Pro Gln Arg Asn Lys Val Gly Ser Leu Phe Lys Gln Tyr Arg Asp
165 170 175
Ala Leu Gln Glu Ala Ala Ser Thr Leu Leu Trp Arg Gln Phe Leu Ala
180 185 190
Asp Asn Pro Cys Leu Glu Asn Leu Cys Leu Lys Leu Gly Tyr Val His
195 200 205
Ala Ser Asp Ile Pro Phe Glu Glu Leu Cys Thr Leu Glu Leu Lys Gly
210 215 220
Gln Pro Thr Phe Leu Glu Val Tyr Val Val Gly His Asn Ile Asn Gly
225 230 235 240
Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile Asn Asn Lys Gln Gly
245 250 255
Ile Pro Ala Ala Phe Lys Val Ser Arg Asn Phe Met Pro Arg Cys Gly
260 265 270
Lys Ile Leu Phe Asn Asp Leu Thr Phe Ala Leu Pro Asn Pro Thr His
275 280 285
Ala Ala Arg Lys Asp Phe Lys Asp Trp Glu Glu Gly Thr Pro Thr Ser
290 295 300
Ala Asp Tyr Lys Phe Gln Phe Val Lys Phe Met Val Arg Asp Thr Phe
305 310 315 320
Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala Ala Ala Tyr Ala Leu
325 330 335
Pro Val Glu Lys Gly Cys Cys Pro Tyr Lys Ala Val Asn Glu Phe Tyr
340 345 350
Met Leu Gly Thr Tyr Arg Thr Asp Ala Asp Ser Phe Pro Gln Arg Asp
355 360 365
Tyr Trp Ser Ser Asp Glu Glu Tyr Leu Leu Asn Lys Ser Leu Trp Leu
370 375 380
Gln Glu Asn Ser Gly Ala Tyr Asp Ile Val Gln Arg Thr Leu Asp Tyr
385 390 395 400
Cys Ala Met Asp Val Leu Val Thr Ala Glu Leu Val Lys Lys Leu Gln
405 410 415
Ala Ser Tyr Leu Asp Phe Val His Thr Ser Val Gly Leu Pro His Cys
420 425 430
Asn Phe Asn Val Leu Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala
435 440 445
Ile Phe Arg Gln Val Val Tyr Arg Ser Gln Arg Pro Asn Arg Ser Ser
450 455 460
Leu Gly Asn Phe Leu Leu Ala Pro Ser Asn Glu Met Tyr Asp Tyr Val
465 470 475 480
Arg Glu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val
485 490 495
Leu Thr Glu Ala Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser
500 505 510
Ala Leu Thr His Pro Phe Pro Ala Gly Lys Pro Leu Asn Pro Phe Asp
515 520 525
Arg Ala Leu Ala Ile Lys Asn Trp Gln Asp Arg Leu Thr Gln Leu His
530 535 540
Arg Pro Ile Asp Tyr Phe Asp Arg Thr Leu Leu Pro Ala Ile Phe Thr
545 550 555 560
Ile Asp Ala Asp Pro Pro Pro Glu Ala Phe Leu Asp Val Ile Pro Pro
565 570 575
Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Thr Leu
580 585 590
Arg Gly Glu Val Val Thr Cys Leu Asp Ala Ile Thr Leu His Asn Arg
595 600 605
Gly Trp Arg Val Gln Ile Leu Asn Asp Pro Arg Thr Thr Val Phe Pro
610 615 620
Gln Trp Glu Cys Leu Ala Arg Asp Tyr Val Gln Leu Asn Ile Ala Pro
625 630 635 640
Lys Glu Arg Ala Asp Lys Glu Lys Asn Gln Thr Leu Arg Ser Ile Ala
645 650 655
Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp
660 665 670
Asn Arg Val Thr Val Phe Ser Asp Gln Met Glu Asp Lys Tyr Val Arg
675 680 685
Gly Ile Ser Asp Gly Thr Tyr Asp Ile Lys Ser Thr Ala Phe Val Glu
690 695 700
Thr Asp Asn Leu Ser Ser Ser Val Met Ala Glu Leu Lys Ile Thr Tyr
705 710 715 720
Ser Pro Val Lys Gln Gln Thr Asp Ala Thr Arg Lys His Arg Gln Cys
725 730 735
Thr Pro Thr Ser Asn Ser Ser Ser Asp Glu Asp Ala Pro Phe Tyr Thr
740 745 750
Leu Gly Asp Pro Gln Asn His His Val Thr Tyr Thr Tyr Lys Pro Ile
755 760 765
Thr Phe Leu Glu Ala Asp Asp Ser Ala Leu Cys Leu His Thr Leu Gln
770 775 780
Lys Lys Ser Ser Leu Ile Phe Asn Asn Arg Tyr Pro Ser His Ile Ala
785 790 795 800
Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Asp
805 810 815
Ile Leu Tyr Leu Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Ile Leu
820 825 830
Lys Phe Val Tyr Gly Asp Thr Asp Ser Met Phe Leu Thr Gln Arg Gly
835 840 845
Lys Glu Leu Met Asp Thr Arg Gly Lys His Arg Leu Lys Gly Asn Asn
850 855 860
Arg Pro Leu Val Phe Asp Pro Thr Asn Pro Gln Leu Thr Trp Leu Val
865 870 875 880
Glu Cys Glu Thr Gln Cys Pro Arg Cys His Gly Asp Ala His Ser Gln
885 890 895
Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asn Ile Tyr
900 905 910
Cys Pro Ser Cys Arg Arg Arg Glu Phe Trp Gln Thr Ser Ser Lys Gly
915 920 925
His Ala Thr Ser Gln Leu Ser Tyr Asp Leu Leu Val Thr Cys Tyr Tyr
930 935 940
Ser Thr Glu Gln Leu Gly Asp Glu Lys Phe Gly Thr Ser Arg Leu Ser
945 950 955 960
Leu Arg Arg Ser Leu Val Ser Arg Gln Thr His Gln Gln Pro Phe Thr
965 970 975
Val Thr Glu Thr Thr Leu Ala Arg Thr Leu Arg Pro Trp Lys Asp Arg
980 985 990
Thr Leu Arg Ala Ile Asp Arg His Arg Leu Ala Pro Tyr Ser Asn Ser
995 1000 1005
His Pro Asn Pro Arg Asn Lys Glu Leu Cys Trp Met Glu Met Tyr
1010 1015 1020
<210> 21
<211> 1163
<212> PRT
<213> 牛腺病毒B（Bovine adenovirus B）
<400> 21
Met Ala Leu Val Gln Ser Asp Gly Ala Ser Ser Ile His Pro Thr Pro
1 5 10 15
Gly Asp Ser Glu Asn Gln Pro Gln Ser Arg Ala Ala Arg Ile Arg Pro
20 25 30
Ala Pro Thr Ala Ala Thr His Ala Arg Thr Gln Arg Ser Gly Pro Ala
35 40 45
Thr Ala Pro Gln Ala Arg Lys Ala Lys Ala Ala Pro Arg Pro Ser Thr
50 55 60
Ser Pro Leu Lys Lys Ala Pro Arg Gly Pro Leu Val Ala Lys Arg Ser
65 70 75 80
Thr Leu Arg Leu His Gly Gln Thr Glu Asp Gly Thr Thr Leu Glu Val
85 90 95
Lys Tyr His Ala Asp Val Ser Ser Ser Leu Arg Asn Leu Phe Glu Leu
100 105 110
His Leu Glu His Cys Pro Phe Asp Leu Lys Pro Glu Asn Ile Leu Ser
115 120 125
Phe Gln Asp Thr Leu Val Arg Phe Cys Asn Ala Asn Met Cys Val Tyr
130 135 140
Lys Thr Tyr Lys Gly Lys Leu Lys Ile Thr Ser Ile Pro Ala Arg Ala
145 150 155 160
Asp Arg Pro Arg Leu Pro Phe Pro Leu Asn Phe Leu Ile His Lys Arg
165 170 175
Lys Leu Tyr Leu Ile Asp Thr Ile Ala Glu Val Gln Arg Cys Ala Asp
180 185 190
Cys Gly Ser Tyr Phe Lys Gln Thr His Thr Cys Ser Thr Arg Arg Arg
195 200 205
Asp Phe Tyr Phe His His Ile Asn Thr Gln Ser Ser Asp Trp Trp Glu
210 215 220
Glu Ile Lys Phe Phe Pro Trp Ala Ala His Pro Asp Thr Arg Arg Leu
225 230 235 240
Phe Val Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Ser Phe Gly
245 250 255
Lys Gln Leu Met Pro Phe Met Leu Val Phe Thr Leu Phe Gly Asp Ala
260 265 270
Gln Leu Cys Glu Gln Ala Val Asn Ile Ala Lys Lys Gln Lys Trp Ser
275 280 285
Ser Trp Pro Lys Gln Ala Asn Thr Phe Tyr Tyr Leu Asn Pro Gln Arg
290 295 300
Asn Lys Val Gly Ser Leu Phe Lys Gln Tyr Arg Asp Ala Leu Gln Glu
305 310 315 320
Ala Ala Ser Thr Leu Leu Trp Arg Gln Phe Leu Ala Asp Asn Pro Cys
325 330 335
Leu Glu Asn Leu Cys Leu Lys Leu Gly Tyr Val His Ala Ser Asp Ile
340 345 350
Pro Phe Glu Glu Leu Cys Thr Leu Glu Leu Lys Gly Gln Pro Thr Phe
355 360 365
Leu Glu Val Tyr Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile
370 375 380
Val Leu Ala Ala Gln Val Ile Asn Asn Lys Gln Gly Ile Pro Ala Ala
385 390 395 400
Phe Lys Val Ser Arg Asn Phe Met Pro Arg Cys Gly Lys Ile Leu Phe
405 410 415
Asn Asp Leu Thr Phe Ala Leu Pro Asn Pro Thr His Ala Ala Arg Lys
420 425 430
Asp Phe Lys Asp Trp Glu Glu Gly Thr Pro Thr Ser Ala Asp Tyr Lys
435 440 445
Phe Gln Phe Val Lys Phe Met Val Arg Asp Thr Phe Ala Leu Thr His
450 455 460
Thr Ser Leu Arg Asn Ala Ala Ala Ala Tyr Ala Leu Pro Val Glu Lys
465 470 475 480
Gly Cys Cys Pro Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Thr
485 490 495
Tyr Arg Thr Asp Ala Asp Ser Phe Pro Gln Arg Asp Tyr Trp Ser Ser
500 505 510
Asp Glu Glu Tyr Leu Leu Asn Lys Ser Leu Trp Leu Gln Glu Asn Ser
515 520 525
Gly Ala Tyr Asp Ile Val Gln Arg Thr Leu Asp Tyr Cys Ala Met Asp
530 535 540
Val Leu Val Thr Ala Glu Leu Val Lys Lys Leu Gln Ala Ser Tyr Leu
545 550 555 560
Asp Phe Val His Thr Ser Val Gly Leu Pro His Cys Asn Phe Asn Val
565 570 575
Leu Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln
580 585 590
Val Val Tyr Arg Ser Gln Arg Pro Asn Arg Ser Ser Leu Gly Asn Phe
595 600 605
Leu Leu Ala Pro Ser Asn Glu Met Tyr Asp Tyr Val Arg Glu Ser Ile
610 615 620
Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Thr Glu Ala
625 630 635 640
Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His
645 650 655
Pro Phe Pro Ala Gly Lys Pro Leu Asn Pro Phe Asp Arg Ala Leu Ala
660 665 670
Ile Lys Asn Trp Gln Asp Arg Leu Thr Gln Leu His Arg Pro Ile Asp
675 680 685
Tyr Phe Asp Arg Thr Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp
690 695 700
Pro Pro Pro Glu Ala Phe Leu Asp Val Ile Pro Pro Phe Cys Ser Arg
705 710 715 720
Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Thr Leu Arg Gly Glu Val
725 730 735
Val Thr Cys Leu Asp Ala Ile Thr Leu His Asn Arg Gly Trp Arg Val
740 745 750
Gln Ile Leu Asn Asp Pro Arg Thr Thr Val Phe Pro Gln Trp Glu Cys
755 760 765
Leu Ala Arg Asp Tyr Val Gln Leu Asn Ile Ala Pro Lys Glu Arg Ala
770 775 780
Asp Lys Glu Lys Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser
785 790 795 800
Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Arg Val Thr
805 810 815
Val Phe Ser Asp Gln Met Glu Asp Lys Tyr Val Arg Gly Ile Ser Asp
820 825 830
Gly Thr Tyr Asp Ile Lys Ser Thr Ala Phe Val Glu Thr Asp Asn Leu
835 840 845
Ser Ser Ser Val Met Ala Glu Leu Lys Ile Thr Tyr Ser Pro Val Lys
850 855 860
Gln Gln Thr Asp Ala Thr Arg Lys His Arg Gln Cys Thr Pro Thr Ser
865 870 875 880
Asn Ser Ser Ser Asp Glu Asp Ala Pro Phe Tyr Thr Leu Gly Asp Pro
885 890 895
Gln Asn His His Val Thr Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Glu
900 905 910
Ala Asp Asp Ser Ala Leu Cys Leu His Thr Leu Gln Lys Lys Ser Ser
915 920 925
Leu Ile Phe Asn Asn Arg Tyr Pro Ser His Ile Ala Ser Phe Val Leu
930 935 940
Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Asp Ile Leu Tyr Leu
945 950 955 960
Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Ile Leu Lys Phe Val Tyr
965 970 975
Gly Asp Thr Asp Ser Met Phe Leu Thr Gln Arg Gly Lys Glu Leu Met
980 985 990
Asp Thr Arg Gly Lys His Arg Leu Lys Gly Asn Asn Arg Pro Leu Val
995 1000 1005
Phe Asp Pro Thr Asn Pro Gln Leu Thr Trp Leu Val Glu Cys Glu
1010 1015 1020
Thr Gln Cys Pro Arg Cys His Gly Asp Ala His Ser Gln Glu Ser
1025 1030 1035
Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asn Ile Tyr Cys
1040 1045 1050
Pro Ser Cys Arg Arg Arg Glu Phe Trp Gln Thr Ser Ser Lys Gly
1055 1060 1065
His Ala Thr Ser Gln Leu Ser Tyr Asp Leu Leu Val Thr Cys Tyr
1070 1075 1080
Tyr Ser Thr Glu Gln Leu Gly Asp Glu Lys Phe Gly Thr Ser Arg
1085 1090 1095
Leu Ser Leu Arg Arg Ser Leu Val Ser Arg Gln Thr His Gln Gln
1100 1105 1110
Pro Phe Thr Val Thr Glu Thr Thr Leu Ala Arg Thr Leu Arg Pro
1115 1120 1125
Trp Lys Asp Arg Thr Leu Arg Ala Ile Asp Arg His Arg Leu Ala
1130 1135 1140
Pro Tyr Ser Asn Ser His Pro Asn Pro Arg Asn Lys Glu Leu Cys
1145 1150 1155
Trp Met Glu Met Tyr
1160
<210> 22
<211> 1192
<212> PRT
<213> 猴腺病毒22（Simian adenovirus 22）
<400> 22
Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala
1 5 10 15
Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser
20 25 30
Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro
35 40 45
Ala Ala Pro Ala Ser Gly Pro Arg Ala Ala Pro Ala Ala Arg Arg Ala
50 55 60
Ser Ser Pro Pro Leu Leu Ser Met Glu Pro Pro Pro Pro Ala Pro Lys
65 70 75 80
Lys Lys Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln
85 90 95
Ala Val Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu
100 105 110
Asp Leu Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro
115 120 125
Pro Leu Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser
130 135 140
Ser Gly Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu
145 150 155 160
Val Trp Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu
165 170 175
Ala Asp Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Gln Met
180 185 190
Gln Pro Pro Ala Leu His Cys Pro Leu Lys Phe Leu Val Lys Gly Thr
195 200 205
Gln Val Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His
210 215 220
Cys Gly Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg
225 230 235 240
His Phe Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln
245 250 255
Glu Ile Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu
260 265 270
Phe Leu Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly
275 280 285
Lys Gln Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro
290 295 300
Pro Leu Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp
305 310 315 320
Arg Trp His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys
325 330 335
Met Ala Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr
340 345 350
Ala Leu Ala Val Asp Leu Trp Thr Ser Phe Leu Gly Ala Asn Pro His
355 360 365
Leu Ala Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu
370 375 380
Leu Thr Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro
385 390 395 400
Arg Phe Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp
405 410 415
Glu Ile Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro
420 425 430
Gln Pro Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile
435 440 445
Leu Phe Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys
450 455 460
Arg Thr Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp
465 470 475 480
Phe Lys His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu
485 490 495
Thr His Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val
500 505 510
Glu Lys Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val
515 520 525
Gly Ser Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp
530 535 540
Lys Asp Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys
545 550 555 560
Gly Gln Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala
565 570 575
Leu Asp Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser
580 585 590
Tyr Ala His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe
595 600 605
Asn Ile Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe
610 615 620
Arg Gln Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly
625 630 635 640
Thr Gly Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala
645 650 655
Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu
660 665 670
Glu Pro Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu
675 680 685
Thr His Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala
690 695 700
Leu Ala Val Arg Asp Trp Gln Ala Ala Leu Asp Asp Leu Gly Thr Cys
705 710 715 720
Ile Ser Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp
725 730 735
Ala Asp Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys
740 745 750
Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly
755 760 765
Glu Val Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp
770 775 780
Arg Val Arg Ile Val Pro Asp Lys Leu Thr Thr Val Phe Pro Glu Trp
785 790 795 800
Lys Cys Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu
805 810 815
Arg Ala Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu
820 825 830
Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys
835 840 845
Lys Ile Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val
850 855 860
Ser Asn Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp
865 870 875 880
Asn Leu Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro
885 890 895
Gln Gln Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu
900 905 910
Gln Gly Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His
915 920 925
Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly
930 935 940
Asp Met Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn
945 950 955 960
Asp Arg Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg
965 970 975
Ala Phe Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly
980 985 990
Thr Pro Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp
995 1000 1005
Ser Leu Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg
1010 1015 1020
Gly Lys Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp
1025 1030 1035
Pro Asp Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val
1040 1045 1050
Cys Ala Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe
1055 1060 1065
Leu Ala Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val
1070 1075 1080
Cys Gly His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala
1085 1090 1095
Ala Glu Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala
1100 1105 1110
Asp Ala Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met
1115 1120 1125
Ser Leu Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro
1130 1135 1140
Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp
1145 1150 1155
Lys Asp Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro
1160 1165 1170
Tyr Ser Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp
1175 1180 1185
Ile Glu Met Pro
1190
<210> 23
<211> 1190
<212> PRT
<213> 猴腺病毒23（Simian adenovirus 23）
<400> 23
Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala
1 5 10 15
Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser
20 25 30
Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro
35 40 45
Ala Ala Pro Ala Ser Gly Pro Arg Ala Ala Pro Ala Ala Arg Arg Ala
50 55 60
Ser Ser Pro Pro Leu Leu Thr Asp Met Glu Ala Ala Pro Lys Lys Lys
65 70 75 80
Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln Ala Val
85 90 95
Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu Asp Leu
100 105 110
Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro Pro Leu
115 120 125
Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser Ser Gly
130 135 140
Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu Val Trp
145 150 155 160
Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu Ala Asp
165 170 175
Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Glu Met Gln Pro
180 185 190
Pro Ala Leu His Cys Pro Leu Lys Phe Leu Ala Lys Gly Thr Gln Val
195 200 205
Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His Cys Gly
210 215 220
Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg His Phe
225 230 235 240
Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln Glu Ile
245 250 255
Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu
260 265 270
Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln
275 280 285
Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro Pro Leu
290 295 300
Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp Arg Trp
305 310 315 320
His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys Met Ala
325 330 335
Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr Ala Leu
340 345 350
Ala Val Asp Leu Trp Thr Ser Phe Leu Ser Ala Asn Pro His Val Ala
355 360 365
Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu Leu Thr
370 375 380
Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro Arg Phe
385 390 395 400
Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile
405 410 415
Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro Gln Pro
420 425 430
Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe
435 440 445
Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys Arg Thr
450 455 460
Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp Phe Lys
465 470 475 480
His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His
485 490 495
Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys
500 505 510
Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val Gly Ser
515 520 525
Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp Lys Asp
530 535 540
Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys Gly Gln
545 550 555 560
Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala Leu Asp
565 570 575
Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser Tyr Ala
580 585 590
His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe Asn Ile
595 600 605
Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln
610 615 620
Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly Thr Gly
625 630 635 640
Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile
645 650 655
Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu Glu Pro
660 665 670
Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His
675 680 685
Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala
690 695 700
Val Arg Asp Trp Gln Ala Ala Leu Asp Asn Leu Gly Thr Cys Ile Ser
705 710 715 720
Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp Ala Asp
725 730 735
Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg
740 745 750
Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val
755 760 765
Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val
770 775 780
Arg Ile Val Pro Asp Glu Leu Thr Thr Val Phe Pro Glu Trp Lys Cys
785 790 795 800
Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala
805 810 815
Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser
820 825 830
Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile
835 840 845
Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val Ser Asn
850 855 860
Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp Asn Leu
865 870 875 880
Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro Gln Gln
885 890 895
Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu Gln Gly
900 905 910
Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His Val Ala
915 920 925
Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly Asp Met
930 935 940
Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn Asp Arg
945 950 955 960
Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe
965 970 975
Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly Thr Pro
980 985 990
Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu
995 1000 1005
Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg Gly Lys
1010 1015 1020
Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp Pro Asn
1025 1030 1035
Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Ala
1040 1045 1050
Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe Leu Ala
1055 1060 1065
Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val Cys Gly
1070 1075 1080
His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala Ala Glu
1085 1090 1095
Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala Asp Ala
1100 1105 1110
Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met Ser Leu
1115 1120 1125
Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro Phe Thr
1130 1135 1140
Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp
1145 1150 1155
Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro Tyr Ser
1160 1165 1170
Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp Ile Glu
1175 1180 1185
Met Pro
1190
<210> 24
<211> 1190
<212> PRT
<213> 猴腺病毒24（Simian adenovirus 24）
<400> 24
Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala
1 5 10 15
Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser
20 25 30
Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro
35 40 45
Ala Ala Pro Ala Ser Gly Ser Arg Ala Ala Pro Ala Ala Arg Arg Ala
50 55 60
Ser Ser Pro Pro Leu Leu Thr Gly Met Glu Ala Ala Pro Lys Lys Lys
65 70 75 80
Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln Ala Val
85 90 95
Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu Asp Leu
100 105 110
Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro Pro Leu
115 120 125
Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser Ser Gly
130 135 140
Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu Val Trp
145 150 155 160
Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu Ala Asp
165 170 175
Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Gln Met Gln Pro
180 185 190
Pro Ala Leu His Cys Pro Leu Lys Phe Leu Val Lys Gly Thr Gln Val
195 200 205
Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His Cys Gly
210 215 220
Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg His Phe
225 230 235 240
Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln Glu Ile
245 250 255
Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu
260 265 270
Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln
275 280 285
Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro Pro Leu
290 295 300
Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp Arg Trp
305 310 315 320
His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys Met Ala
325 330 335
Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr Ala Leu
340 345 350
Ala Val Asp Leu Trp Thr Ser Phe Leu Ser Ala Asn Pro His Val Ala
355 360 365
Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu Leu Thr
370 375 380
Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro Arg Phe
385 390 395 400
Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile
405 410 415
Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro Gln Pro
420 425 430
Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe
435 440 445
Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys Arg Thr
450 455 460
Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp Phe Lys
465 470 475 480
His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His
485 490 495
Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys
500 505 510
Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val Gly Ser
515 520 525
Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp Lys Asp
530 535 540
Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys Gly Gln
545 550 555 560
Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala Leu Asp
565 570 575
Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser Tyr Ala
580 585 590
His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe Asn Ile
595 600 605
Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln
610 615 620
Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly Thr Gly
625 630 635 640
Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile
645 650 655
Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu Glu Pro
660 665 670
Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His
675 680 685
Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala
690 695 700
Val Arg Asp Trp Gln Ala Ala Leu Asp Asp Leu Asp Thr Cys Ile Ser
705 710 715 720
Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp Ala Asp
725 730 735
Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg
740 745 750
Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val
755 760 765
Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val
770 775 780
Arg Ile Val Pro Asp Glu Leu Thr Thr Val Phe Pro Glu Trp Lys Cys
785 790 795 800
Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala
805 810 815
Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser
820 825 830
Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile
835 840 845
Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val Ser Asn
850 855 860
Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp Asn Leu
865 870 875 880
Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro Gln Gln
885 890 895
Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu Gln Gly
900 905 910
Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His Val Ala
915 920 925
Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly Asp Met
930 935 940
Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn Asp Arg
945 950 955 960
Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe
965 970 975
Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly Thr Pro
980 985 990
Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu
995 1000 1005
Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg Gly Lys
1010 1015 1020
Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp Pro Asn
1025 1030 1035
Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Ala
1040 1045 1050
Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe Leu Ala
1055 1060 1065
Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val Cys Gly
1070 1075 1080
His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala Ala Glu
1085 1090 1095
Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala Asp Ala
1100 1105 1110
Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met Ser Leu
1115 1120 1125
Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro Phe Thr
1130 1135 1140
Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp
1145 1150 1155
Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro Tyr Ser
1160 1165 1170
Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp Ile Glu
1175 1180 1185
Met Pro
1190
<210> 25
<211> 1184
<212> PRT
<213> 猴腺病毒7（Simian adenovirus 7）
<400> 25
Met Ala Leu Val Gln Asp Pro Gly Ala Gly Gly Leu His Ala Glu Thr
1 5 10 15
Ala His Pro Gly Pro Gln Pro Pro Arg Arg Arg Pro Arg Gln Gln Ser
20 25 30
Pro Gly Ser Ser Ser Thr Ala Ala Glu Ser Ser Arg Lys Arg Ala Ser
35 40 45
Ala Ser Ala Ala Pro Arg Arg Arg Ala Ala Ser Thr Pro Arg Arg Ser
50 55 60
Pro Ser Thr Ser Glu Ile Lys Pro Pro Arg Gly Thr Val Val Ala Pro
65 70 75 80
Arg Gly His Gly Leu Leu Tyr Ala Val Asp Ala Ser Ser Asn Thr Pro
85 90 95
Leu Glu Ile Lys Tyr His Leu His Leu Ala His Ala Leu Thr Gly Leu
100 105 110
Leu Lys Val Asn Leu Gln Thr Leu Pro Ala Asp Leu Ser Ala Thr Ser
115 120 125
Leu Asp Ser Leu Asp Ser Gly Gln Leu Arg Pro Leu Leu Gln Arg Leu
130 135 140
His Pro Ser Val Ala Glu Ile Trp Thr Cys Gly Thr Arg Gly Val Val
145 150 155 160
Val Pro Thr Val Val His Pro Glu Lys Glu Asp Ala Asp Ala Asp Ser
165 170 175
His Arg Gln Gly Glu Gly Asp Val Ala Pro Pro Ala Pro Arg Leu Asn
180 185 190
Phe Pro Leu Arg Phe Leu Val Arg Gly Arg Lys Ala His Leu Val Gln
195 200 205
Glu Ile Gln Ser Val Gln Arg Cys Asp Tyr Cys Gly Arg Phe Tyr Lys
210 215 220
His Gln His Glu Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His His
225 230 235 240
Ile Asn Thr His Ser Ser Ser Trp Trp Gln Glu Ile Ser Phe Phe Pro
245 250 255
Ile Gly Ser His Ala Arg Thr Gln Arg Leu Phe Val Thr Tyr Asp Val
260 265 270
Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln Leu Val Pro Phe
275 280 285
Met Leu Val Met His Val Ser Gly Glu Glu Thr Leu Val Arg Gln Ala
290 295 300
Cys Glu Leu Ala Leu Glu Leu Arg Trp Asp Val Trp Asn Asn Arg Pro
305 310 315 320
Asn Thr Phe Tyr Val Val Thr Pro Glu Lys Met Ala Val Gly Lys Lys
325 330 335
Phe Arg Glu Phe Arg Asp Arg Leu Gln Thr Leu Leu Ala Leu Asp Leu
340 345 350
Trp Ser Ser Phe Leu Ala Ala Asn Pro Gln Leu Ser Asp Trp Ala Arg
355 360 365
Ala Glu Leu Gly Leu Ser Ser Pro Asp Cys Leu Thr Tyr Glu Glu Leu
370 375 380
Lys Lys Ala Pro Ala Leu Lys Gly Gln Pro Arg Phe Ile Glu Leu Tyr
385 390 395 400
Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala
405 410 415
Gln Val Ile Asn Asn Arg Ser Asp Val Pro Gly Pro Phe Arg Ile Ser
420 425 430
Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr
435 440 445
Phe Ala Leu Pro Asn Pro Arg Gln Lys Lys Arg Thr Asp Phe Thr Leu
450 455 460
Trp Glu Gln Gly Ala Cys Asp Asp Thr Asp Phe Lys His Gln Tyr Leu
465 470 475 480
Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg
485 490 495
Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Pro
500 505 510
Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Ser Tyr Arg Ala Asp
515 520 525
Glu Lys Gly Phe Pro Ala Glu Glu Tyr Trp Lys Asp Arg Glu Glu Tyr
530 535 540
Leu Leu Asn Arg Glu Leu Trp Glu Lys Lys Gln Glu Thr Ala Tyr Asn
545 550 555 560
Leu Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr
565 570 575
Ala Ala Leu Val Asp Lys Leu Arg Glu Ser Tyr Ala Gln Phe Ile Gln
580 585 590
Asp Ser Val Gly Leu Pro Gly Ala Asn Phe Asn Val Phe Gln Arg Pro
595 600 605
Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Tyr Arg
610 615 620
Ala Glu Lys Pro His Lys Thr His Leu Gly Asp Gly Leu Met Ala Pro
625 630 635 640
Ser Arg Glu Met Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg
645 650 655
Cys Tyr Pro Thr Tyr Ile Gly Val Leu Arg Glu Pro Leu Tyr Val Tyr
660 665 670
Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp
675 680 685
Gly Pro Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Val Lys Lys Trp
690 695 700
Glu Asp Ala Leu Gln Asp Thr Asp Thr Glu Ile Asp Tyr Phe Asn Lys
705 710 715 720
Ile Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Pro Ala
725 730 735
Asn Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg
740 745 750
Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val
755 760 765
Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Ile Leu Pro
770 775 780
Asp Glu Arg Thr Ala Val Phe Pro Glu Trp Arg Cys Ala Ala Arg Glu
785 790 795 800
Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Glu Lys
805 810 815
Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr
820 825 830
Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp
835 840 845
Gln Met Asp Pro Ser Thr Ile Lys Ser Ile Ala Ala Gly His Val Asn
850 855 860
Ile Lys Ser Thr Ser Phe Val Glu Thr Asp Asn Leu Ser Ala Glu Ile
865 870 875 880
Met Pro Ala Phe Glu Arg Ala Tyr Ser Pro Glu Gln Leu Ala Leu Val
885 890 895
His Ser Asp Ala Glu Glu Ser Asp Gly Glu Gly Gly His Ala Pro Phe
900 905 910
Tyr Thr Pro Leu Gly Gly Ala Asp His Val Thr Tyr Thr Tyr Lys Pro
915 920 925
Ile Thr Phe Val Asp Ala Glu Glu Asp Asp Leu Cys Leu His Thr Leu
930 935 940
Glu Lys Val Asp Pro Leu Ile Glu Asn Asp Arg Tyr Pro Ser Gln Ile
945 950 955 960
Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser
965 970 975
Gln Phe Leu Tyr Ala Glu Asp Leu Gly Thr Pro Leu Glu Asp Arg Pro
980 985 990
Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala
995 1000 1005
Gly His Lys Leu Met Glu Thr Gln Gly Lys Lys Arg Ile Lys Lys
1010 1015 1020
Asn Gly Gly Asn Leu Val Phe Asp Pro Ala Lys Pro Glu Leu Thr
1025 1030 1035
Trp Leu Val Glu Cys Glu Thr Val Cys Ala Gln Cys Gly Ala Asp
1040 1045 1050
Ala Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala
1055 1060 1065
Leu Gln Cys Leu His Cys Thr Lys Cys Gln His Val Ser Lys Gly
1070 1075 1080
Lys Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Ser Tyr Asp
1085 1090 1095
Leu Met Leu Arg Cys Tyr Leu Ala Asp Ser Gln Gly Asp Asp Val
1100 1105 1110
Arg Phe Ser Thr Ser Arg Met Ser Leu Lys Arg Thr Leu Ala Ser
1115 1120 1125
Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu
1130 1135 1140
Thr Arg Thr Leu Arg Pro Trp Lys Asp Arg Thr Leu Ala Ala Leu
1145 1150 1155
Asp Ala His Arg Leu Val Pro Tyr Ser Glu Ser Arg Pro Asn Pro
1160 1165 1170
Arg Asn Gln Glu Val Cys Trp Ile Glu Ile Pro
1175 1180
<210> 26
<211> 1184
<212> PRT
<213> 猴腺病毒1（Simian adenovirus 1）
<400> 26
Met Ala Leu Val Gln Asp Pro Gly Ala Gly Gly Leu His Ala Glu Thr
1 5 10 15
Ala His Pro Gly Pro Gln Pro Pro Arg Arg Arg Pro Arg Gln Gln Ser
20 25 30
Pro Gly Ser Ser Ser Thr Ala Ala Glu Ser Ser Arg Lys Arg Ala Thr
35 40 45
Ala Ser Ala Ala Pro Arg Arg Arg Ala Ala Ser Thr Pro Arg Arg Ser
50 55 60
Pro Ser Thr Ser Glu Ile Lys Pro Pro Arg Gly Thr Val Val Ala Pro
65 70 75 80
Arg Gly His Gly Leu Leu Tyr Ala Val Asp Ala Ser Ser Asn Thr Pro
85 90 95
Leu Glu Ile Lys Tyr His Val His Leu Ala His Ala Leu Thr Gly Leu
100 105 110
Leu Lys Val Asn Leu Gln Thr Leu Pro Ala Asp Leu Ser Ala Ala Ala
115 120 125
Leu Asp Ser Leu Asp Ser Gly Gln Leu Arg Pro Leu Leu Gln Arg Leu
130 135 140
Arg Pro Ser Val Ala Glu Ile Trp Thr Cys Gly Thr Arg Gly Val Val
145 150 155 160
Val Pro Thr Val Val His Pro Glu Lys Glu Gly Ala Asp Ala Asp Ser
165 170 175
His Arg Gln Gly Glu Gly Asp Ala Ala Pro Pro Ser Pro Arg Leu Asn
180 185 190
Phe Pro Leu Arg Phe Leu Val Arg Gly Arg Lys Ala His Leu Ile Gln
195 200 205
Glu Ile Gln Ser Val Gln Arg Cys Asp Tyr Cys Gly Arg Phe Tyr Lys
210 215 220
His Gln His Glu Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His His
225 230 235 240
Ile Asn Thr His Ser Ser Asn Trp Trp Gln Glu Ile Ser Phe Phe Pro
245 250 255
Ile Gly Ser His Ala Arg Thr Gln Arg Leu Phe Val Thr Tyr Asp Val
260 265 270
Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln Leu Val Pro Phe
275 280 285
Met Leu Val Met His Val Ser Gly Glu Glu Thr Leu Val Arg Gln Ala
290 295 300
Cys Glu Leu Ala Leu Glu Leu Arg Trp Asp Val Trp Asn Asp Arg Pro
305 310 315 320
Cys Thr Phe Tyr Val Val Thr Pro Glu Lys Met Ala Val Gly Lys Lys
325 330 335
Phe Arg Glu Phe Arg Asp Arg Leu Gln Thr Leu Leu Ala Leu Asp Leu
340 345 350
Trp Ser Ser Phe Leu Ala Ala Asn Pro Gln Leu Ser Asp Trp Ala Arg
355 360 365
Ala Glu Leu Gly Leu Ser Ser Pro Asp Cys Leu Thr Tyr Glu Glu Leu
370 375 380
Lys Lys Ala Pro Ala Leu Lys Gly Gln Pro Arg Phe Ile Glu Leu Tyr
385 390 395 400
Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala
405 410 415
Gln Val Ile Asn Asn Arg Ser Asp Val Pro Gly Pro Phe Arg Ile Ser
420 425 430
Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr
435 440 445
Phe Ala Leu Pro Asn Pro Arg Gln Lys Lys Arg Thr Asp Phe Thr Leu
450 455 460
Trp Glu Gln Gly Ala Cys Asp Asp Thr Asp Phe Lys His Gln Tyr Leu
465 470 475 480
Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg
485 490 495
Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Pro
500 505 510
Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Ser Tyr Arg Ala Asp
515 520 525
Glu Lys Gly Phe Pro Ala Glu Glu Tyr Trp Lys Asp Arg Glu Glu Tyr
530 535 540
Leu Leu Asn Arg Glu Leu Trp Glu Lys Lys Gln Glu Thr Ala Tyr Asn
545 550 555 560
Leu Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr
565 570 575
Ala Ala Leu Val Asp Lys Leu Arg Glu Ser Tyr Ala Gln Phe Ile Gln
580 585 590
Asp Ser Val Gly Leu Pro Gly Ala Asn Phe Asn Val Phe Gln Arg Pro
595 600 605
Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Tyr Arg
610 615 620
Ala Glu Lys Pro His Lys Thr His Leu Gly Asp Gly Leu Met Ala Pro
625 630 635 640
Ser His Glu Met Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg
645 650 655
Cys Tyr Pro Thr Tyr Ile Gly Val Leu Arg Glu Pro Leu Tyr Val Tyr
660 665 670
Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp
675 680 685
Gly Pro Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Val Lys Lys Trp
690 695 700
Glu Asp Ala Leu Gln Asp Thr Asp Thr Glu Ile Asp Tyr Phe Asn Lys
705 710 715 720
Ile Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Pro Ala
725 730 735
Asn Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg
740 745 750
Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val
755 760 765
Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Ile Leu Pro
770 775 780
Asp Glu Arg Thr Ala Val Phe Pro Glu Trp Arg Cys Val Ala Arg Glu
785 790 795 800
Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Glu Lys
805 810 815
Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr
820 825 830
Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp
835 840 845
Gln Met Asp Pro Ser Thr Ile Lys Ser Ile Ala Ala Gly His Val Asn
850 855 860
Ile Lys Ser Thr Ser Phe Val Glu Thr Asp Asn Leu Ser Ala Glu Ile
865 870 875 880
Met Pro Ala Phe Glu Arg Ala Tyr Ser Pro Glu Gln Leu Ala Leu Val
885 890 895
His Ser Asp Ala Glu Glu Ser Asp Gly Glu Ser Gly His Ala Pro Phe
900 905 910
Tyr Thr Pro Trp Gly Gly Ala Gly His Val Thr Tyr Thr Tyr Lys Pro
915 920 925
Ile Thr Phe Val Asp Ala Glu Glu Asp Asp Leu Cys Leu His Thr Leu
930 935 940
Glu Lys Val Asp Pro Leu Ile Glu Asn Asp Arg Tyr Pro Ser Gln Ile
945 950 955 960
Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser
965 970 975
Gln Phe Leu Tyr Ala Glu Asp Leu Gly Thr Pro Leu Glu Asp Arg Pro
980 985 990
Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala
995 1000 1005
Gly His Arg Leu Met Glu Thr Gln Gly Lys Lys Arg Ile Lys Lys
1010 1015 1020
Asn Gly Gly Asn Leu Val Phe Asp Pro Ala Lys Pro Glu Leu Thr
1025 1030 1035
Trp Leu Val Glu Cys Glu Thr Val Cys Ala Gln Cys Gly Ala Asp
1040 1045 1050
Ala Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala
1055 1060 1065
Leu Lys Cys Leu His Cys Thr Lys Cys Gln His Val Ser Lys Gly
1070 1075 1080
Lys Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Ser Tyr Asp
1085 1090 1095
Leu Met Leu Arg Cys Tyr Leu Ala Asp Ser Gln Gly Asp Asp Ala
1100 1105 1110
Arg Phe Ser Thr Ser Arg Met Ser Leu Lys Arg Thr Leu Ala Ser
1115 1120 1125
Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu
1130 1135 1140
Thr Arg Thr Leu Arg Pro Trp Lys Asp Arg Thr Leu Ala Ala Leu
1145 1150 1155
Asp Ala His Arg Leu Val Pro Tyr Ser Glu Ser Arg Pro Asn Pro
1160 1165 1170
Arg Asn Gln Glu Val Cys Trp Ile Glu Ile Pro
1175 1180
<210> 27
<211> 1169
<212> PRT
<213> 猴腺病毒3（Simian adenovirus 3）
<400> 27
Met Ala Leu Val Gln Asp His Gly Ser Gly Gly Leu His Ala Thr Pro
1 5 10 15
Pro Asp Pro Gly Arg Gln Ser Pro Gly Asp Ser Leu Cys Gln Ser Ala
20 25 30
Pro Arg Ala Ala Pro Ala Pro Ala Arg Ala Pro Arg Arg Arg Ala Ala
35 40 45
Ala Arg Leu Ala Arg Gly Ser Arg Ala Ala Ala Ala Ala Gly Ser Pro
50 55 60
Ser Pro Pro Pro Ile Lys Thr Pro Arg Gly Thr Leu Val Ala Pro Arg
65 70 75 80
Pro His Gly His Leu Phe Ala Leu Asp Ala Arg Asp Arg His Pro Trp
85 90 95
Glu Ile Lys Tyr His Leu His Leu Leu Pro Ala Leu Thr His Leu Leu
100 105 110
Glu Val His Arg Leu Pro Pro Leu Pro Asp Asn Phe Arg Val His Asp
115 120 125
Ser Pro Ser Asp Glu Thr Leu Arg Glu Leu Val Gln Glu Leu Lys Pro
130 135 140
Gln Leu Ala Glu Val Trp Ser Val Arg Gly Arg Gly Thr Val Glu Pro
145 150 155 160
Ser Ser Ile Leu Pro Ala Asp Ala Glu Val Ala Ala Arg Ser Phe Pro
165 170 175
Leu Arg Phe Leu Ala Leu Gly Pro Pro Gln Arg Arg Lys Ile His Leu
180 185 190
Ile His Ser Leu His Ser Val Ser Arg Cys Asp His Cys Gly Arg Phe
195 200 205
Tyr Lys Asn Gln His Glu Cys Ser Thr Arg Arg Arg Asp Phe Tyr Phe
210 215 220
His His Ile His Ala Gln Ser Ser Gln Trp Trp Gln Pro Ile Lys Phe
225 230 235 240
Phe Pro Leu Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu Thr Tyr
245 250 255
Asp Val Glu Thr Tyr Thr Trp Met Gly Ala Phe Gly Lys Gln Leu Val
260 265 270
Pro Phe Leu Leu Val Met Lys Ile Thr Gly Glu Pro Ser Leu Val Arg
275 280 285
Leu Ala Leu Asn Leu Ala Arg Glu Leu Gly Trp Asp Ala Trp Arg Glu
290 295 300
His Ala Asp Thr Phe Phe Cys Leu Asn Pro Gln Lys Gln Ala Ile Gly
305 310 315 320
Arg Lys Phe Arg Glu Phe Arg Asp Arg Leu Gln Leu Leu Leu Val Asp
325 330 335
His Ile Trp Gln Asp Phe Val Glu Arg Asn Pro Val Glu Asp Trp Ser
340 345 350
Arg Thr Glu His Gly Val Glu Pro Arg Glu Leu Thr Phe Gln Gln Leu
355 360 365
Glu Lys Cys Pro Leu Leu Arg Gly Ala Pro Arg Phe Ile Glu Phe Tyr
370 375 380
Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Leu Leu Ala Ala
385 390 395 400
Gln Val Ile Asn Asn Arg Ser Glu Val Pro Gly Pro Phe Arg Ile Ser
405 410 415
Arg Asn Phe Met Pro Arg Cys Gly Lys Ile Leu Phe Asn Asp Val Thr
420 425 430
Tyr Ser Leu Pro Asn Pro Lys His Lys Lys Arg Thr Asp Tyr Ser Asp
435 440 445
Trp Glu Arg Gly Met Cys Asp Asp Arg Asp Phe Lys Tyr Gln Phe Val
450 455 460
Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg
465 470 475 480
Lys Ala Ala Leu Ala Tyr Ser Leu Pro Val Glu Lys Gly Cys Cys Pro
485 490 495
Tyr Gln Ala Val Asn Gln Phe Tyr Met Leu Gly Ser Tyr Arg Gly Asp
500 505 510
Glu Asp Gly Phe Pro Leu Gln Glu Tyr Trp Lys Asp Arg Glu Glu Tyr
515 520 525
Leu Phe Asn Arg Asp Leu Trp Lys Glu Lys Lys Glu Glu His Tyr Asp
530 535 540
Ile Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr
545 550 555 560
Ala Ser Leu Val Glu Lys Leu Gln Glu Ser Tyr Ala His Phe Ile Gly
565 570 575
Glu Ala Val Gly Leu Pro Asp Ala Arg Phe Asn Ile Phe Gln Arg Pro
580 585 590
Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Phe Arg
595 600 605
Asp Glu Lys Pro Gln Arg Ala His Leu Ser Arg His Leu Leu Ala Pro
610 615 620
Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg
625 630 635 640
Cys Tyr Pro Thr Tyr Leu Gly Val Leu Glu Glu Pro Leu Tyr Val Tyr
645 650 655
Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp
660 665 670
Gly Ala Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala Val Arg Asp Trp
675 680 685
Glu Thr Ala Leu Arg Arg Pro Gly His Gln Ile Asp Tyr Phe Asp Lys
690 695 700
His Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu
705 710 715 720
Arg Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg
725 730 735
Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile
740 745 750
Asp Val Ile Thr Leu His Asn Arg Gly Trp Ser Val Arg Leu Val Pro
755 760 765
Asp Glu Arg Thr Ala Val Phe Pro Gly Trp Lys Cys Val Ala Arg Glu
770 775 780
Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Arg Glu Lys
785 790 795 800
Asn Gln Thr Gln Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr
805 810 815
Gly Ser Phe Ala Thr Lys Leu Asp Asn Arg Gln Ile Val Phe Ser Asp
820 825 830
Gln Met Gly Pro Glu His Leu Lys Gly Ile Ser Thr Gly Ala Leu Ala
835 840 845
Ile Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn Leu Ser Ala Gln Val
850 855 860
Met Pro Ala Phe Thr Arg Val Tyr Val Pro Gln Gln Leu Ala Phe Gly
865 870 875 880
Asp Ser Glu Pro Glu Glu Ser Asp Glu Glu Gly Gly Asn Ala Pro Phe
885 890 895
Tyr Thr Pro Ala Glu Gly Gln Asp His Val Thr Tyr Thr Tyr Lys Pro
900 905 910
Ile Thr Phe Leu Glu Ala Asp Glu Gly Asp Met Cys Leu His Thr Leu
915 920 925
Glu Lys Thr Asp Pro Leu Ile Asp Asn Asp Arg Tyr Pro Ser His Ile
930 935 940
Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser Glu Trp Cys
945 950 955 960
Glu Phe Leu Tyr Ala Glu Asp Arg Gly Thr Pro Leu Glu Glu Arg Ala
965 970 975
Leu Thr Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Arg
980 985 990
Gly His Arg Leu Met Glu Thr Arg Gly Arg Lys Arg Ile Lys Lys Asn
995 1000 1005
Gly Gly Arg Leu Val Phe Asp Pro Lys Asp Pro Gln Leu Thr Trp
1010 1015 1020
Leu Val Glu Cys Glu Thr Val Cys Ser Asn Cys Gly Gly Asp Ala
1025 1030 1035
Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu
1040 1045 1050
Lys Cys Leu Leu Cys Ser Asn Cys Gly His Val Ser Lys Gly Lys
1055 1060 1065
Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Asp Tyr Glu Leu
1070 1075 1080
Met Val Arg Cys Tyr Leu Ala Asp Leu Gln Gly Asp Glu Lys Gln
1085 1090 1095
Arg Phe Ala Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Ser
1100 1105 1110
Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu
1115 1120 1125
Lys Arg Thr Leu Arg Pro Trp Arg Asp Arg Thr Met Ala Gln Leu
1130 1135 1140
Asp Ala His Arg Leu Ile Pro Tyr Ser Gln Ser Arg Pro Asn Pro
1145 1150 1155
Arg Asn Glu Glu Val Cys Trp Ile Glu Met Pro
1160 1165
<210> 28
<211> 1017
<212> PRT
<213> 牛腺病毒2（Bovine adenovirus 2）
<400> 28
Met Leu Glu Ala Leu Lys Pro Ala Glu Gly Ala Thr Phe Thr Tyr Ile
1 5 10 15
Lys Gly Arg Leu Ile Lys Gln Gln Ala Ala Val Glu Asn Pro Ile Leu
20 25 30
Pro Phe Pro Ile Phe Phe Leu Ile Lys Gln Asn Lys Val Phe Leu Ile
35 40 45
Lys Ser Phe Gln Ser Ser Gln Lys Cys Glu Phe Cys Gly Asp Phe Phe
50 55 60
Ala Asn Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His
65 70 75 80
His Ile Asn Phe Lys Ser Ser Glu Trp Trp Ser Gln Ile Ser Phe Gln
85 90 95
Pro Ile Gly Ser Cys Asp Asp Thr Lys Arg Phe Phe Leu Thr Tyr Asp
100 105 110
Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro
115 120 125
Phe Met Leu Val Phe His Leu Ser Gly Glu Leu Glu Leu Val Ser Leu
130 135 140
Ser Ala Asn Ile Ala Glu Gln Gln Arg Trp Leu Ala Trp Asp Thr Pro
145 150 155 160
His Thr Tyr Tyr Tyr Val Ser Pro Ile Lys Gly Glu Ile Gly Lys Ala
165 170 175
Phe Lys Asp Leu Arg Tyr Glu Ile Gln Lys Gln Val Thr Arg Leu Leu
180 185 190
Trp Asp Asn Phe Val Gly Glu Asn Pro Glu Leu Ala Glu Ile Gln Glu
195 200 205
Arg His His Val Asn His Ile Asp Asp Ile Thr Ala Glu Met His Lys
210 215 220
Ile Lys Thr Lys Gly Ser Pro Gln Phe Ile Glu Ile Tyr Val Ile Gly
225 230 235 240
His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile
245 250 255
His Asn Arg Thr Asp Val Leu Pro Ala Phe Lys Ile Asn Arg Asn Phe
260 265 270
Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Ser Phe Cys Leu
275 280 285
Pro Asn Pro Lys Tyr Glu Lys Arg Lys Asp Phe Ala Asp Trp Glu Cys
290 295 300
Gly Lys Leu Thr Ala Ala Asp His Lys Tyr Gln Phe Val Lys Phe Met
305 310 315 320
Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala
325 330 335
Gly Ala Tyr Glu Leu Pro Val Glu Lys Gly Ser Cys Pro Tyr Glu Ala
340 345 350
Val Asn Glu Phe Tyr Arg Ile Gly Ser Tyr Gln Gln Asp Glu Asp Gly
355 360 365
Phe Pro Ser Leu Arg Tyr Trp Lys Ser Ser Glu Glu Tyr Gln Leu Asn
370 375 380
Lys Ala Leu Trp Arg Glu Lys Asn Val Gly Ala Tyr Asp Ile Ile Gln
385 390 395 400
Gln Thr Leu His Tyr Cys Val Gln Asp Val Leu Val Thr Ser Ala Leu
405 410 415
Val Asn Lys Leu Gln Glu Ser Tyr Lys Asn Phe Ile Ala Ser Gln Val
420 425 430
Asn Leu Pro Asp Ala Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser
435 440 445
Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Glu Val Arg
450 455 460
Pro Asn Lys Ala Asn Leu Asp Asn Val Leu Leu Ala Pro Ser His Glu
465 470 475 480
Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro
485 490 495
Thr Tyr Ile Gly Ile Met Glu Gln Pro Ile Tyr Val Tyr Asp Ile Cys
500 505 510
Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro Ser Gly Gln Pro
515 520 525
Leu Asn Pro Tyr Glu Arg Ala Leu Ala Ala Thr Glu Trp Ile Arg Lys
530 535 540
Leu Glu Asn Leu Glu Gln Lys Ile Asp Tyr Phe Asp Glu Cys Leu Leu
545 550 555 560
Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Leu Phe Leu
565 570 575
Asp Glu Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp
580 585 590
Ala Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile Asp Leu Ile
595 600 605
Thr Leu His Asn Arg Gly Trp Ala Val Arg Ile Leu Pro Asp Glu Arg
610 615 620
Thr Thr Ile Phe Pro Glu Trp Lys Cys Val Ala Lys Glu Tyr Val Gln
625 630 635 640
Leu Asn Ile Gly Ala Lys Glu Lys Ala Asp Lys Glu Lys Asn Gln Thr
645 650 655
Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe
660 665 670
Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu Glu
675 680 685
Ala Ser Ala Ser Lys Thr Ile Ala Arg Gly Asn Phe Ser Ile Lys Ser
690 695 700
Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Glu Ile Met Pro Glu
705 710 715 720
Phe Val Val Thr Tyr Pro Pro Ala Pro Ser Ala Glu Leu Asp Glu Ser
725 730 735
Asp Glu Asn Glu Glu His Thr Leu Phe Ile Pro Lys Asp Ser His Val
740 745 750
Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Glu Thr Glu Asp Asp Asp
755 760 765
Ile Cys Leu His Thr Leu Glu Asn Asn Ser Pro Leu Ile Glu Asn Asn
770 775 780
Arg Tyr Ala Ser His Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Val
785 790 795 800
Phe Val Ser Glu Trp Ala Glu Phe Leu Tyr Ala Glu Asp Arg Gly Lys
805 810 815
Pro Leu His Gln Arg Thr Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser
820 825 830
Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Glu Gln Arg Gly Lys
835 840 845
His Arg Ile Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Lys Asn
850 855 860
Pro Ser Ile Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys
865 870 875 880
Lys Ser Asp Ala Phe Ser Ser Glu Ser Val Phe Leu Ala Pro Lys Leu
885 890 895
Tyr Ala Leu Lys Asn Thr Val Cys Thr Cys Cys Gly His Val Gly Lys
900 905 910
Gly Lys Leu Arg Ala Lys Gly His Ala Thr Thr Glu Leu Cys Tyr Asp
915 920 925
Thr Leu Ala Lys Cys Tyr Leu Ser Asp Ala Gln Gln Gly Ser Gln Arg
930 935 940
Phe His Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Thr Asn Gln
945 950 955 960
Ser Asn Ala Ala Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr
965 970 975
Val Arg Pro Trp Lys Asp Lys Thr Leu Val Asp Ile Asp Gly His Arg
980 985 990
Leu Met Pro Tyr Ser Lys Ser Asn Pro Asn Pro Arg Asn Asn Asp Val
995 1000 1005
Cys Trp Met Thr Leu Pro Trp Asn Met
1010 1015
<210> 29
<211> 1017
<212> PRT
<213> 绵羊腺病毒A（Ovine adenovirus A）
<400> 29
Met Leu Glu Ala Leu Lys Pro Ala Glu Gly Ala Thr Phe Thr Tyr Ile
1 5 10 15
Lys Gly Arg Leu Ile Lys Gln Gln Ala Ala Val Glu Asn Pro Ile Leu
20 25 30
Pro Phe Pro Ile Phe Phe Leu Ile Lys Gln Asn Lys Val Phe Leu Ile
35 40 45
Lys Ser Phe Gln Ser Ser Gln Lys Cys Glu Phe Cys Gly Asp Phe Phe
50 55 60
Ala Asn Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His
65 70 75 80
His Ile Asn Phe Lys Ser Ser Glu Trp Trp Ser Gln Ile Ser Phe Gln
85 90 95
Pro Ile Gly Ser Cys Asp Asp Thr Lys Arg Phe Phe Leu Thr Tyr Asp
100 105 110
Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro
115 120 125
Phe Met Leu Val Phe His Leu Ser Gly Glu Leu Glu Leu Val Ser Leu
130 135 140
Ser Ala Asn Ile Ala Glu Gln Gln Arg Trp Leu Ala Trp Asp Thr Pro
145 150 155 160
His Thr Tyr Tyr Tyr Val Ser Pro Ile Lys Gly Glu Ile Gly Lys Ala
165 170 175
Phe Lys Asp Leu Arg Tyr Glu Ile Gln Lys Gln Val Thr Arg Leu Leu
180 185 190
Trp Asp Asn Phe Val Gly Glu Asn Pro Glu Leu Ala Glu Ile Gln Glu
195 200 205
Arg His His Val Asn His Ile Asp Asp Ile Thr Ala Glu Met His Lys
210 215 220
Ile Lys Thr Lys Gly Ser Pro Gln Phe Ile Glu Ile Tyr Val Ile Gly
225 230 235 240
His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile
245 250 255
His Asn Arg Thr Asp Val Leu Pro Ala Phe Lys Ile Asn Arg Asn Phe
260 265 270
Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Ser Phe Cys Leu
275 280 285
Pro Asn Pro Lys Tyr Glu Lys Arg Lys Asp Phe Ala Asp Trp Glu Cys
290 295 300
Gly Lys Leu Thr Ala Ala Asp His Lys Tyr Gln Phe Val Lys Phe Met
305 310 315 320
Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala
325 330 335
Gly Ala Tyr Glu Leu Pro Val Glu Lys Gly Ser Cys Pro Tyr Glu Ala
340 345 350
Val Asn Glu Phe Tyr Arg Ile Gly Ser Tyr Gln Gln Asp Glu Asp Gly
355 360 365
Phe Pro Ser Leu Arg Tyr Trp Lys Ser Ser Glu Glu Tyr Gln Leu Asn
370 375 380
Lys Ala Leu Trp Arg Glu Lys Asn Val Gly Ala Tyr Asp Ile Ile Gln
385 390 395 400
Gln Thr Leu His Tyr Cys Val Gln Asp Val Leu Val Thr Ser Ala Leu
405 410 415
Val Asn Lys Leu Gln Glu Ser Tyr Lys Asn Phe Ile Ala Ser Gln Val
420 425 430
Asn Leu Pro Asp Ala Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser
435 440 445
Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Glu Val Arg
450 455 460
Pro Asn Lys Ala Asn Leu Asp Asn Val Leu Leu Ala Pro Ser His Glu
465 470 475 480
Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro
485 490 495
Thr Tyr Ile Gly Ile Met Glu Gln Pro Ile Tyr Val Tyr Asp Ile Cys
500 505 510
Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro Ser Gly Gln Pro
515 520 525
Leu Asn Pro Tyr Glu Arg Ala Leu Ala Ala Thr Glu Trp Ile Arg Lys
530 535 540
Leu Glu Asn Leu Glu Gln Lys Ile Asp Tyr Phe Asp Glu Cys Leu Leu
545 550 555 560
Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Leu Phe Leu
565 570 575
Asp Glu Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp
580 585 590
Ala Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile Asp Leu Ile
595 600 605
Thr Leu His Asn Arg Gly Trp Ala Val Arg Ile Leu Pro Asp Glu Arg
610 615 620
Thr Thr Ile Phe Pro Glu Trp Lys Cys Val Ala Lys Glu Tyr Val Gln
625 630 635 640
Leu Asn Ile Gly Ala Lys Glu Lys Ala Asp Lys Glu Lys Asn Gln Thr
645 650 655
Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe
660 665 670
Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu Glu
675 680 685
Ala Ser Ala Ser Lys Thr Ile Ala Arg Gly Asn Phe Ser Ile Lys Ser
690 695 700
Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Glu Ile Met Pro Glu
705 710 715 720
Phe Val Val Thr Tyr Pro Pro Ala Pro Ser Ala Glu Leu Asp Glu Ser
725 730 735
Asp Glu Asn Glu Glu His Thr Leu Phe Ile Pro Lys Asp Ser His Val
740 745 750
Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Glu Thr Glu Asp Asp Asp
755 760 765
Ile Cys Leu His Thr Leu Glu Asn Asn Ser Pro Leu Ile Glu Asn Asn
770 775 780
Arg Tyr Ala Ser His Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Val
785 790 795 800
Phe Val Ser Glu Trp Ala Glu Phe Leu Tyr Ala Glu Asp Arg Gly Lys
805 810 815
Pro Leu His Gln Arg Thr Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser
820 825 830
Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Glu Gln Arg Gly Lys
835 840 845
His Arg Ile Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Lys Asn
850 855 860
Pro Ser Ile Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys
865 870 875 880
Lys Ser Asp Ala Phe Ser Ser Glu Ser Val Phe Leu Ala Pro Lys Leu
885 890 895
Tyr Ala Leu Lys Asn Thr Val Cys Thr Cys Cys Gly His Val Gly Lys
900 905 910
Gly Lys Leu Arg Ala Lys Gly His Ala Thr Thr Glu Leu Cys Tyr Asp
915 920 925
Thr Leu Ala Lys Cys Tyr Leu Ser Asp Ala Gln Gln Gly Ser Gln Arg
930 935 940
Phe His Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Thr Asn Gln
945 950 955 960
Ser Asn Ala Ala Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr
965 970 975
Val Arg Pro Trp Lys Asp Lys Thr Leu Val Asp Ile Asp Gly His Arg
980 985 990
Leu Met Pro Tyr Ser Lys Ser Asn Pro Asn Pro Arg Asn Asn Asp Val
995 1000 1005
Cys Trp Met Thr Leu Pro Trp Asn Met
1010 1015
<210> 30
<211> 1130
<212> PRT
<213> 猪腺病毒C（Porcine adenovirus C）
<400> 30
Met Ser Val Val Pro Ser Asp Gly Ser Gly Arg Leu Leu Gly Ala Glu
1 5 10 15
Gly His Pro Lys His Gln Gln Lys Gly Arg Gly His Gly Asp Glu Ala
20 25 30
Glu Thr Gly Arg Gln Thr Tyr Ala Gly Thr Ala Arg Gly Arg Pro Ala
35 40 45
Arg Ser Gly Pro Val Arg Gly Asn Leu Val Ala Lys Arg Ala Thr Leu
50 55 60
Ser Ala Ser Gly Thr Leu Glu Asp Gly Thr His Val Asp Ile Lys Phe
65 70 75 80
His Ser Lys Thr Leu Glu Ala Leu Glu Asn Leu Phe His Leu His Leu
85 90 95
Leu Gln Leu Pro Pro Leu Pro Pro Ile Ser Thr Ser Asn Val Ser Asp
100 105 110
Val Leu Gln Leu Leu Ala Pro Arg Glu Gly Ser Val Val Val Tyr Asn
115 120 125
Arg Gly Arg Val Ser Val Lys Gln Val Glu Ile Arg Glu Pro Lys Ala
130 135 140
His Phe Asp Ile Gln Phe Leu Leu Lys Gln Gly Lys Val Tyr Leu Ile
145 150 155 160
Lys Glu Ile Gln Asp Thr Gln Lys Cys Glu Tyr Cys Gly Asp Phe Phe
165 170 175
Lys Thr Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His
180 185 190
His Val His His Lys Ser Ser Asp Trp Trp Glu Asn Ile Pro Phe Gln
195 200 205
Pro Leu Gly Ser Tyr Arg Glu Thr Glu Arg Leu Tyr Ile Thr Tyr Asp
210 215 220
Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro
225 230 235 240
Phe Leu Leu Val Phe His Ile Ser Gly Glu Pro His Leu Val Lys Val
245 250 255
Ala Glu Ser Val Ala Gln Asp Leu Asn Trp Cys Pro Trp Thr Glu Lys
260 265 270
His Thr Phe Tyr Tyr Leu Asn Pro Gln Lys Ser Ala Val Gly Arg Met
275 280 285
Phe Lys Ser Phe Arg Asp Glu Leu Gln Asn Arg Val Thr Gln Asp Leu
290 295 300
Trp Lys Thr Phe Leu Ser Gln Asn Pro His Leu Val Glu Thr Ala Ala
305 310 315 320
Arg Leu Asn Leu Gly Ser Val Asp Asp Ile Thr Pro Glu Val Leu Lys
325 330 335
Lys Glu Lys Ile Cys Gly Glu Pro Arg Phe Ile Glu Val Tyr Val Ile
340 345 350
Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val
355 360 365
Ile Cys His Gln Ser Lys Thr Ile Lys Ala Phe Lys Ile Ser Arg Asn
370 375 380
Phe Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Thr Phe Gly
385 390 395 400
Leu Pro Asn Pro Leu Phe Glu Lys Arg Lys Glu Phe Gln Glu Trp Glu
405 410 415
Arg Gly Ser Met Ala Val Gln Asp Met Lys Gln Gln Phe Val Lys Leu
420 425 430
Met Val Arg Asp Thr Leu Met Leu Thr His Thr Ser Leu Arg Asn Ala
435 440 445
Ala Lys Ala Tyr Asp Leu Pro Val Glu Lys Gly Cys Cys Pro Tyr Glu
450 455 460
Ala Val Asn Glu Phe Tyr Arg Thr Gly Thr Tyr Gln Lys Asp Glu Asp
465 470 475 480
Gly Phe Pro Ser Leu Arg Tyr Trp Lys Asp Gln Glu Glu Tyr Ala Leu
485 490 495
Asn Lys Glu Leu Trp Arg Glu Lys Lys Cys Gly Ala Tyr Asp Leu Ile
500 505 510
Ser Ser Thr Leu Thr Tyr Cys Ala Gln Asp Val Leu Val Thr Ser Ser
515 520 525
Leu Val Arg Lys Leu Gln Glu Ser Tyr Gln Ser Phe Ile Ala Asn Glu
530 535 540
Val Asn Leu Pro Asp Ser Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile
545 550 555 560
Ser Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Ala Glu
565 570 575
Lys Pro Glu Arg Gln His Leu Gly Glu Val Leu Leu Ala Pro Ser Asn
580 585 590
Glu Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr
595 600 605
Pro Thr Tyr Ile Gly Ile Leu His Glu Pro Ile Tyr Val Tyr Asp Ile
610 615 620
Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Ser Gly Ser
625 630 635 640
Pro Leu Asn Pro Phe Glu Arg Ala Leu Ala Val Ala Val Trp Glu Asp
645 650 655
Gln Leu Lys Ser Val Gly Gln Lys Met Asp Tyr Phe Asp Glu Lys Leu
660 665 670
Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Ser Phe
675 680 685
Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys
690 695 700
Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val Asp Val
705 710 715 720
Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Leu Val Pro Asp Glu
725 730 735
Arg Thr Thr Ile Phe Pro Glu Trp Lys Cys Leu Ala Lys Glu Tyr Val
740 745 750
Gln Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Arg Glu Lys Asn Gln
755 760 765
Thr Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser
770 775 780
Phe Ala Thr Arg Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu
785 790 795 800
Glu Glu Glu Ser Ser Lys Asn Ile Ser Arg Gly Lys Tyr Ser Val Lys
805 810 815
Ser Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Asp Ile Met Pro
820 825 830
Glu Phe Val Val Ala Tyr Pro Pro Val Ala Asp Val Ser Asn Glu Asp
835 840 845
Asn Glu Ala Ala Glu Glu Ala Thr Pro Phe Ile Gly Lys Ser Asp His
850 855 860
Val Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Asp Val Glu Asp Asp
865 870 875 880
Asp Val Cys Leu His Thr Leu Glu Ser Ser Ser Ser Leu Val Leu Asn
885 890 895
Asn Arg Tyr Ala Ser His Leu Ala Ser Phe Val Leu Ala Trp Ala Arg
900 905 910
Val Phe Val Ser Glu Trp Ser Glu Phe Leu Tyr Glu Asn Asp Arg Gly
915 920 925
Val Pro Met Glu Glu Arg Gln Ile Lys Ser Val Tyr Gly Asp Thr Asp
930 935 940
Ser Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Lys Glu Lys Gly
945 950 955 960
Lys His Arg Ile Lys Lys Asn Gly Gly Ser Leu Val Phe Asp Pro Gln
965 970 975
His Pro Gln Val Thr Trp Leu Val Glu Cys Glu Thr Arg Cys Asp Lys
980 985 990
Cys Gly Glu Asp Ala Tyr Ser Pro Thr Ser Val Phe Leu Ala Pro Lys
995 1000 1005
Leu Tyr Ala Leu Lys Ser Thr Val Cys Ser Val Cys Gly Tyr Val
1010 1015 1020
Gly Lys Gly Lys Leu Arg Ala Lys Gly His Ala Thr Ser Glu Leu
1025 1030 1035
Ser Phe Asp Val Leu Gln Arg Cys Tyr Leu Glu Asp Leu Gln Leu
1040 1045 1050
Gly Ser Glu Lys Phe Lys Thr Ser Arg Leu Ser Leu Lys Arg Thr
1055 1060 1065
Leu Ala Ser Cys Gln Ser Asn Ala Ala Pro Phe Thr Val Thr Glu
1070 1075 1080
Ala Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp Lys Thr Leu
1085 1090 1095
Thr Gln Ile Asp Gln Asn Arg Leu Ile Pro Tyr Ser Thr Ser Arg
1100 1105 1110
Pro Asn Pro Arg Asn Thr Asp Leu Cys Trp Met Thr Leu Pro Trp
1115 1120 1125
Asp Ser
1130
<210> 31
<211> 1136
<212> PRT
<213> 树鼩腺病毒（Tree shrew adenovirus）
<400> 31
Met Ala Leu Val Gln Ser Asp Arg Pro Arg Ser Leu Gln Pro Glu Ser
1 5 10 15
Gly Asn Ser Lys His Gln Pro Glu Ser Arg Arg Leu Arg Val Ser Ser
20 25 30
Glu Ala Ala Thr Pro Ala Ser Ser Gly Pro Gln Pro Ser Arg Ser Ser
35 40 45
Ala Pro Ala Leu Thr Arg Tyr Lys Gly Thr Val Val Ala Lys Arg Ala
50 55 60
Thr Cys Val Ile Asn Ala Thr Asp Glu Glu Gly Cys Phe Val Glu Ile
65 70 75 80
Lys Tyr His Val Asp Thr Asp Lys Ser Leu Gln Ala Leu Phe Asp Val
85 90 95
His Leu Ser Glu Arg Pro Glu Glu Ala Gly Asn Phe Thr Ala His Asn
100 105 110
Val Val Ala Lys Leu Glu Ala Ile Arg Pro Ser Gln Ala Ser Ile Val
115 120 125
Lys Tyr Phe Arg Gly Lys Ile Lys Thr Thr His Val Ala Ile Glu Asn
130 135 140
Pro Arg Phe Ser Phe Pro Ile Arg Phe Leu Ile Lys Asn His Gln Leu
145 150 155 160
Phe Leu Ile Lys Glu Ile Cys Thr Thr Met Lys Cys Glu His Cys Gly
165 170 175
Arg Tyr Phe Lys Gly Thr His Thr Cys Ser Ala Arg Arg Arg Asp Phe
180 185 190
Tyr Phe His His Ile Asn Ala Gln Ser Ser Ser Trp Trp Glu Pro Ile
195 200 205
Ser Phe Phe Pro Leu Gly Ala Pro Pro Glu Thr Lys Arg Leu Tyr Ile
210 215 220
Thr Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Lys Phe Gly Lys Gln
225 230 235 240
Leu Val Pro Phe Met Leu Val Leu His Leu Ser Gly Asp Asp Glu Leu
245 250 255
Leu Ala Asp Ala Ile Thr Leu Ile Arg Gln Thr Ser Tyr Ile Pro Trp
260 265 270
Pro Lys His Asp Asn Thr Phe Tyr Tyr Leu Asn Pro Thr Lys Lys Thr
275 280 285
Val Gly Gln Leu Phe Lys Ser Leu Arg Asn Thr Leu Gln Thr His Phe
290 295 300
Ala Lys Lys Leu Trp Gln Leu Phe Leu Asp Gln Asn Pro Lys Ile Thr
305 310 315 320
Glu Tyr Cys Gln Leu Lys Gln Leu Asp Pro Asp Gln Leu Thr Ala Asp
325 330 335
Glu Leu Lys Asn Met Lys Ile Val Gly Thr Pro Ser Phe Trp Glu Val
340 345 350
Tyr Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala
355 360 365
Ala Gln Ile Ile Ser Asn Lys Ser Asp Val Pro Ala Ser Phe His Ile
370 375 380
Thr Arg Asn Phe Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile
385 390 395 400
Thr Phe Gly Leu Pro Asn Pro Ala Ser Lys Lys Arg Gln Asp Phe Thr
405 410 415
Leu Trp Glu Gln Gly Gly Cys Glu Ala Ser Asp Phe Lys Trp Gln Tyr
420 425 430
Val Lys Phe Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu
435 440 445
Arg Lys Ala Ala Ala Ala Tyr Ala Leu Asp Val Glu Lys Gly Ser Cys
450 455 460
Pro Tyr Lys Ala Val Asn Glu Phe Tyr Met Phe Gly Ser Tyr Gln Val
465 470 475 480
Asp Glu Val Gly Phe Pro Asp Glu His Tyr Trp Ser Ser Arg Glu Glu
485 490 495
Tyr Leu Phe Asn Arg Glu Glu Trp Leu Lys Lys Lys Glu His Ala Tyr
500 505 510
Asp Ile Ile Thr Gln Thr Leu Glu Tyr Cys Val Met Asp Val Val Val
515 520 525
Thr Ala Lys Leu Val Gln Lys Leu Gln Thr Ser Tyr Ala Ala Phe Val
530 535 540
Gln Glu Ser Val Asn Leu Pro Glu Ser Ser Phe Asn Val Phe Gln Arg
545 550 555 560
Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Val Tyr
565 570 575
Arg Ala Glu Lys Pro Gln Lys Thr His Leu Gly Gln Cys Leu Leu Ala
580 585 590
Pro Ser Asn Glu Met Tyr Asp Tyr Val Arg Ser Ser Ile Arg Gly Gly
595 600 605
Arg Cys Tyr Pro Ser Tyr Ile Gly Leu Leu Ser Glu Pro Ile Tyr Val
610 615 620
Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro
625 630 635 640
Ser Gly Arg Pro Leu Asn Pro Phe Asp Arg Ala Leu Ala Val Lys Asn
645 650 655
Trp Glu Met Arg Leu Lys Asn Ser Gln Thr Ile Asp Tyr Phe Thr Pro
660 665 670
His Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Ser Glu
675 680 685
Thr Tyr Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg
690 695 700
Leu Cys Trp Thr Asn Glu Ser Leu Arg Gly Glu Val Ala Thr Ser Val
705 710 715 720
Asp Ile Ile Thr Leu His Asn Arg Gly Trp Lys Val Arg Ile Val Thr
725 730 735
Asp Glu Arg Thr Thr Val Phe Pro Glu Trp Lys Cys Ile Ala Gln Glu
740 745 750
Tyr Val Lys Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Glu Lys
755 760 765
Asn Gln Thr Ile Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr
770 775 780
Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Thr Val Phe Ala Asp
785 790 795 800
Gln Leu Asp Ser Ser Thr Ala Lys Gly Ile Ala Asn Gly Glu Phe Ser
805 810 815
Val Lys Ser Ser Ser Phe Ile Glu Thr Asp Cys Leu Ser Ala Glu Ile
820 825 830
Met Ser Glu Leu Val Val Ala Tyr Ser Pro Asp Thr Leu Leu His Pro
835 840 845
Gln Gln Glu Gly Ala Thr Glu Ala Asn Thr Gln Glu Thr Pro Thr Phe
850 855 860
Ile Gly Pro Thr Asp His Val Thr Tyr Thr Tyr Lys Pro Ile Thr Phe
865 870 875 880
Leu Glu Ala Glu Glu Asp Glu Ile Cys Leu Gln Thr Ile Glu Lys Asn
885 890 895
Ser Pro Leu Ile Pro Asn Asp Arg Tyr Pro Ser His Ile Ala Ser Phe
900 905 910
Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Ser Phe Leu
915 920 925
Tyr Ser Glu Asp Leu Gly Thr Pro Met Glu Arg Arg Cys Leu Lys Ser
930 935 940
Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Glu Gly Arg Arg
945 950 955 960
Leu Met Glu Thr Lys Gly Lys His Arg Ile Lys Lys Asn Gly Gly Lys
965 970 975
Leu Val Phe Asp Pro Ala Asn Pro Asp Leu Thr Trp Leu Val Glu Cys
980 985 990
Glu Thr Gln Cys Glu Lys Cys Gly Ala Asp Ala Phe Ser Ser Gln Ser
995 1000 1005
Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys
1010 1015 1020
Pro Val Cys Lys His Val Gly Lys Gly Lys Leu Arg Ala Lys Gly
1025 1030 1035
His Ala Thr Asp Gly Leu Ser Phe Glu Ile Met Ser Lys Cys Tyr
1040 1045 1050
Phe Ala Asp Ser Gln Leu Gly Ser Asp Lys Phe Gln Thr Ser Arg
1055 1060 1065
Met Ser Ile Lys Arg Thr Leu Ala Ser Gly Gln Ser His Val Gln
1070 1075 1080
Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro
1085 1090 1095
Trp Lys Asp Lys Thr Met Thr Ala Leu Asp Gln His Arg Leu Ile
1100 1105 1110
Pro Tyr Ser Asn Ser Cys Pro Asn Pro Arg Asn Asn Glu Val Cys
1115 1120 1125
Trp Ile Glu Met Ser Glu Thr Met
1130 1135
<210> 32
<211> 1198
<212> PRT
<213> 人腺病毒5（Human adenovirus 5）
<400> 32
Met Ala Leu Val Gln Ala His Arg Ala Arg Arg Leu His Ala Glu Ala
1 5 10 15
Pro Asp Ser Gly Asp Gln Pro Pro Arg Arg Arg Val Arg Gln Gln Pro
20 25 30
Thr Arg Ala Ala Pro Ala Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro
35 40 45
Ala Pro Ser Pro Gly Gly Ser Gly Ala Pro Pro Thr Ser Gly Gly Ser
50 55 60
Pro Ala Ser Pro Leu Leu Asp Ala Ser Ser Lys Asp Thr Pro Ala Ala
65 70 75 80
His Arg Pro Pro Arg Gly Thr Val Val Ala Pro Arg Gly Cys Gly Leu
85 90 95
Leu Gln Ala Ile Asp Ala Ala Thr Asn Gln Pro Leu Glu Ile Arg Tyr
100 105 110
His Leu Asp Leu Ala Arg Ala Leu Thr Arg Leu Cys Glu Val Asn Leu
115 120 125
Gln Glu Leu Pro Pro Asp Leu Thr Pro Arg Glu Leu Gln Thr Met Asp
130 135 140
Ser Ser His Leu Arg Asp Val Val Ile Lys Leu Arg Pro Pro Arg Ala
145 150 155 160
Asp Ile Trp Thr Leu Gly Ser Arg Gly Val Val Val Arg Ser Thr Val
165 170 175
Thr Pro Leu Glu Gln Pro Asp Gly Gln Gly Gln Ala Ala Glu Val Glu
180 185 190
Asp His Gln Pro Asn Pro Pro Gly Glu Gly Leu Lys Phe Pro Leu Cys
195 200 205
Phe Leu Val Arg Gly Arg Gln Val Asn Leu Val Gln Asp Val Gln Pro
210 215 220
Val His Arg Cys Gln Tyr Cys Ala Arg Phe Tyr Lys Ser Gln His Glu
225 230 235 240
Cys Ser Ala Arg Arg Arg Asp Phe Tyr Phe His His Ile Asn Ser His
245 250 255
Ser Ser Asn Trp Trp Arg Glu Ile Gln Phe Phe Pro Ile Gly Ser His
260 265 270
Pro Arg Thr Glu Arg Leu Phe Val Thr Tyr Asp Val Glu Thr Tyr Thr
275 280 285
Trp Met Gly Ala Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Met
290 295 300
Lys Phe Gly Gly Asp Glu Pro Leu Val Thr Ala Ala Arg Asp Leu Ala
305 310 315 320
Ala Asn Leu Gly Trp Asp Arg Trp Glu Gln Asp Pro Leu Thr Phe Tyr
325 330 335
Cys Ile Thr Pro Glu Lys Met Ala Ile Gly Arg Gln Phe Arg Thr Phe
340 345 350
Arg Asp His Leu Gln Met Leu Met Ala Arg Asp Leu Trp Ser Ser Phe
355 360 365
Val Ala Ser Asn Pro His Leu Ala Asp Trp Ala Leu Ser Glu His Gly
370 375 380
Leu Ser Ser Pro Glu Glu Leu Thr Tyr Glu Glu Leu Lys Lys Leu Pro
385 390 395 400
Ser Ile Lys Gly Ile Pro Arg Phe Leu Glu Leu Tyr Ile Val Gly His
405 410 415
Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile Asn
420 425 430
Asn Arg Ser Glu Val Pro Gly Pro Phe Arg Ile Thr Arg Asn Phe Met
435 440 445
Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr Phe Ala Leu Pro
450 455 460
Asn Pro Arg Ser Lys Lys Arg Thr Asp Phe Leu Leu Trp Glu Gln Gly
465 470 475 480
Gly Cys Asp Asp Thr Asp Phe Lys Tyr Gln Tyr Leu Lys Val Met Val
485 490 495
Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala Gln
500 505 510
Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Ala Tyr Gln Ala Val
515 520 525
Asn Gln Phe Tyr Met Leu Gly Ser Tyr Arg Ser Glu Ala Asp Gly Phe
530 535 540
Pro Ile Gln Glu Tyr Trp Lys Asp Arg Glu Glu Phe Val Leu Asn Arg
545 550 555 560
Glu Leu Trp Lys Lys Lys Gly Gln Asp Lys Tyr Asp Ile Ile Lys Glu
565 570 575
Thr Leu Asp Tyr Cys Ala Leu Asp Val Gln Val Thr Ala Glu Leu Val
580 585 590
Asn Lys Leu Arg Asp Ser Tyr Ala Ser Phe Val Arg Asp Ala Val Gly
595 600 605
Leu Thr Asp Ala Ser Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser
610 615 620
Asn Ser His Ala Ile Phe Arg Gln Ile Val Phe Arg Ala Glu Gln Pro
625 630 635 640
Ala Arg Ser Asn Leu Gly Pro Asp Leu Leu Ala Pro Ser His Glu Leu
645 650 655
Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr
660 665 670
Tyr Leu Gly Ile Leu Arg Glu Pro Leu Tyr Val Tyr Asp Ile Cys Gly
675 680 685
Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp Gly Pro Pro Leu
690 695 700
Asn Pro Tyr Glu Arg Ala Leu Ala Ala Arg Ala Trp Gln Gln Ala Leu
705 710 715 720
Asp Leu Gln Gly Cys Lys Ile Asp Tyr Phe Asp Ala Arg Leu Leu Pro
725 730 735
Gly Val Phe Thr Val Asp Ala Asp Pro Pro Asp Glu Thr Gln Leu Asp
740 745 750
Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr
755 760 765
Asn Glu Arg Leu Arg Gly Glu Val Ala Thr Ser Val Asp Leu Val Thr
770 775 780
Leu His Asn Arg Gly Trp Arg Val His Leu Val Pro Asp Glu Arg Thr
785 790 795 800
Thr Val Phe Pro Glu Trp Arg Cys Val Ala Arg Glu Tyr Val Gln Leu
805 810 815
Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Asp Lys Asn Gln Thr Leu
820 825 830
Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala
835 840 845
Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Met Asp Ala
850 855 860
Ala Thr Leu Lys Gly Ile Thr Ala Gly Gln Val Asn Ile Lys Ser Ser
865 870 875 880
Ser Phe Leu Glu Thr Asp Asn Leu Ser Ala Glu Val Met Pro Ala Phe
885 890 895
Gln Arg Glu Tyr Ser Pro Gln Gln Leu Ala Leu Ala Asp Ser Asp Ala
900 905 910
Glu Glu Ser Glu Asp Glu Arg Ala Pro Thr Pro Phe Tyr Ser Pro Pro
915 920 925
Ser Gly Thr Pro Gly His Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe
930 935 940
Leu Asp Ala Glu Glu Gly Asp Met Cys Leu His Thr Leu Glu Arg Val
945 950 955 960
Asp Pro Leu Val Asp Asn Asp Arg Tyr Pro Ser His Leu Ala Ser Phe
965 970 975
Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Glu Phe Leu
980 985 990
Tyr Glu Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Pro Leu Lys Ser
995 1000 1005
Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Arg Gly His
1010 1015 1020
Arg Leu Met Glu Thr Arg Gly Lys Lys Arg Ile Lys Lys His Gly
1025 1030 1035
Gly Asn Leu Val Phe Asp Pro Glu Arg Pro Glu Leu Thr Trp Leu
1040 1045 1050
Val Glu Cys Glu Thr Val Cys Gly Ala Cys Gly Ala Asp Ala Tyr
1055 1060 1065
Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys
1070 1075 1080
Ser Leu His Cys Pro Ser Cys Gly Ala Ser Ser Lys Gly Lys Leu
1085 1090 1095
Arg Ala Lys Gly His Ala Ala Glu Gly Leu Asp Tyr Asp Thr Met
1100 1105 1110
Val Lys Cys Tyr Leu Ala Asp Ala Gln Gly Glu Asp Arg Gln Arg
1115 1120 1125
Phe Ser Thr Ser Arg Thr Ser Leu Lys Arg Thr Leu Ala Ser Ala
1130 1135 1140
Gln Pro Gly Ala His Pro Phe Thr Val Thr Gln Thr Thr Leu Thr
1145 1150 1155
Arg Thr Leu Arg Pro Trp Lys Asp Met Thr Leu Ala Arg Leu Asp
1160 1165 1170
Glu His Arg Leu Leu Pro Tyr Ser Glu Ser Arg Pro Asn Pro Arg
1175 1180 1185
Asn Glu Glu Ile Cys Trp Ile Glu Met Pro
1190 1195
<210> 33
<211> 911
<212> PRT
<213> 牛腺病毒3（Bovine adenovirus 3）
<400> 33
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Ser Tyr Phe Asn Ile Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Ala Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Phe Ala Pro Lys Ser
115 120 125
Ala Pro Asn Asn Thr Gln Phe Arg Gln Ala Asn Asn Gly His Pro Ala
130 135 140
Gln Thr Ile Ala Gln Ala Ser Tyr Val Ala Thr Ile Gly Gly Ala Asn
145 150 155 160
Asn Asp Leu Gln Met Gly Val Asp Glu Arg Gln Leu Pro Val Tyr Ala
165 170 175
Asn Thr Thr Tyr Gln Pro Glu Pro Gln Leu Gly Ile Glu Gly Trp Thr
180 185 190
Ala Gly Ser Met Ala Val Ile Asp Gln Ala Gly Gly Arg Val Leu Arg
195 200 205
Asn Pro Thr Gln Thr Pro Cys Tyr Gly Ser Tyr Ala Lys Pro Thr Asn
210 215 220
Glu His Gly Gly Ile Thr Lys Ala Asn Thr Gln Val Glu Lys Lys Tyr
225 230 235 240
Tyr Arg Thr Gly Asp Asn Gly Asn Pro Glu Thr Val Phe Tyr Thr Glu
245 250 255
Glu Ala Asp Val Leu Thr Pro Asp Thr His Leu Val His Ala Val Pro
260 265 270
Ala Ala Asp Arg Ala Lys Val Glu Gly Leu Ser Gln His Ala Ala Pro
275 280 285
Asn Arg Pro Asn Phe Ile Gly Phe Arg Asp Cys Phe Val Gly Leu Met
290 295 300
Tyr Tyr Asn Ser Gly Gly Asn Leu Gly Val Leu Ala Gly Gln Ser Ser
305 310 315 320
Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser
325 330 335
Tyr Gln Met Leu Leu Ala Asn Thr Thr Asp Arg Ser Arg Tyr Phe Ser
340 345 350
Met Trp Asn Gln Ala Met Asp Ser Tyr Asp Pro Glu Val Arg Val Ile
355 360 365
Asp Asn Val Gly Val Glu Asp Glu Met Pro Asn Tyr Cys Phe Pro Leu
370 375 380
Ser Gly Val Gln Ile Gly Asn Arg Ser His Glu Val Gln Arg Asn Gln
385 390 395 400
Gln Gln Trp Gln Asn Val Ala Asn Ser Asp Asn Asn Tyr Ile Gly Lys
405 410 415
Gly Asn Leu Pro Ala Met Glu Ile Asn Leu Ala Ala Asn Leu Trp Arg
420 425 430
Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Asn Leu Lys
435 440 445
Phe Thr Pro His Asn Ile Gln Leu Pro Pro Asn Thr Asn Thr Tyr Glu
450 455 460
Tyr Met Asn Gly Arg Ile Pro Val Ser Gly Leu Ile Asp Thr Tyr Val
465 470 475 480
Asn Ile Gly Thr Arg Trp Ser Pro Asp Val Met Asp Asn Val Asn Pro
485 490 495
Phe Asn His His Arg Asn Ser Gly Leu Arg Tyr Arg Ser Gln Leu Leu
500 505 510
Gly Asn Gly Arg Phe Cys Asp Phe His Ile Gln Val Pro Gln Lys Phe
515 520 525
Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu
530 535 540
Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly
545 550 555 560
Asn Asp Leu Arg Val Asp Gly Ala Thr Val Asn Ile Thr Ser Val Asn
565 570 575
Leu Tyr Ala Ser Phe Phe Pro Met Ser His Asn Thr Ala Ser Thr Leu
580 585 590
Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr
595 600 605
Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro Asn Ala Thr Gln
610 615 620
Leu Pro Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Leu
625 630 635 640
Thr Arg Leu Lys Gln Arg Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp
645 650 655
Pro Tyr Phe Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe
660 665 670
Tyr Leu Ser His Thr Phe Arg Lys Val Ala Ile Gln Phe Asp Ser Ser
675 680 685
Val Thr Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu
690 695 700
Ile Lys Ile Ser Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn
705 710 715 720
Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile
725 730 735
Gly Tyr Gln Gly Tyr His Leu Pro Pro Asp Tyr Lys Asp Arg Thr Phe
740 745 750
Ser Phe Leu His Asn Phe Ile Pro Met Cys Arg Gln Val Pro Asn Pro
755 760 765
Ala Thr Glu Gly Tyr Phe Gly Leu Gly Ile Val Asn His Arg Thr Thr
770 775 780
Pro Ala Tyr Trp Phe Arg Phe Cys Arg Ala Pro Arg Glu Gly His Pro
785 790 795 800
Tyr Pro Gln Leu Ala Leu Pro Pro His Trp Asp Pro Arg His Ala Leu
805 810 815
Arg Asp Pro Glu Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile
820 825 830
Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly
835 840 845
Gln Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe
850 855 860
Glu Met Asp Pro Ile Asn Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu
865 870 875 880
Val Phe Asp Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu
885 890 895
Val Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905 910
<210> 34
<211> 917
<212> PRT
<213> 绵羊腺病毒6（Ovine adenovirus 6）
<400> 34
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Ser Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Ser His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr
65 70 75 80
Lys Thr Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Ile Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ser
115 120 125
Cys Pro Asn Asn Thr Gln Phe Ala Pro Ala Gln Asn Gly Tyr Pro His
130 135 140
Arg Val Ile Ala Gln Ala Ser Tyr Ala Gly Ala Ile Glu Gly Gln Asn
145 150 155 160
Asp Glu Leu Arg Val Gly Ala Asn Glu Arg Gly Gln Pro Val Tyr Ala
165 170 175
Asp Ala Arg Tyr Gln Pro Glu Pro Gln Ile Gly Val Glu Gly Trp Thr
180 185 190
Ala Gly Thr Leu Ala Thr Ile Asn Gln Ala Gly Ala Arg Val Leu Arg
195 200 205
Asn Thr Pro Ala Arg Pro Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn
210 215 220
Pro Glu Gly Gly Gln Ala Arg Val Gly Thr Gln Val Gln Lys Asp Tyr
225 230 235 240
Tyr Arg Val Asp Ala Asn Gly Asn Gly Asn Pro Asn Ala Val Leu Tyr
245 250 255
Ser Glu Glu Val Asp Leu Lys Thr Pro Asp Thr His Leu Leu His Ala
260 265 270
Thr Glu Val Pro Ala Asn Gly Ala Val Thr Val Asp Ala Leu Ser Gln
275 280 285
Leu Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Cys Phe
290 295 300
Ile Gly Leu Met Tyr Tyr Asn Ser Gly Gly Asn Leu Gly Val Leu Ala
305 310 315 320
Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn
325 330 335
Thr Glu Leu Ser Tyr Gln Met Leu Leu Ala Asn Thr Thr Asp Arg Ser
340 345 350
Arg Tyr Phe Ser Met Trp Asn Gln Ala Met Asp Thr Tyr Asp Pro Glu
355 360 365
Val Arg Val Ile Asp Asn Ile Gly Val Glu Asp Glu Met Pro Asn Tyr
370 375 380
Cys Phe Pro Met Ser Gly Val Ala Phe Gly Ala Pro Met Thr Lys Val
385 390 395 400
Gln Lys Asn Gln Asn Ala Trp Gln Ala Val Ala Asn Gly Gly Asn Met
405 410 415
Tyr Val Ser Arg Gly Asn Leu Gly Ala Met Glu Ile Asn Leu Ser Ala
420 425 430
Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro
435 440 445
Asp Asp Gln Lys Tyr Thr Pro Thr Asn Val Arg Leu Pro Ala Asn Thr
450 455 460
Asn Thr Tyr Glu Tyr Met Asn Gly Arg Lys Pro Leu Gln Gly Phe Leu
465 470 475 480
Asp Ser Tyr Val Asn Ile Gly Thr Arg Trp Ser Pro Asp Ala Met Asp
485 490 495
Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg
500 505 510
Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Asp Phe His Ile Gln Val
515 520 525
Pro Gln Lys Phe Phe Ala Val Arg Asn Leu Leu Leu Leu Pro Gly Thr
530 535 540
Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln
545 550 555 560
Ser Thr Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Asn Ile
565 570 575
Thr Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ser His Asn Thr
580 585 590
Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser
595 600 605
Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro
610 615 620
Asn Ala Thr Gln Leu Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala
625 630 635 640
Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Gln Arg Glu Thr Pro Ala
645 650 655
Leu Gly Ser Ala Phe Asp Pro Tyr Phe Thr Tyr Ser Gly Thr Ile Pro
660 665 670
Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Arg Arg Val Ala
675 680 685
Ile Gln Phe Asp Ser Ser Val Thr Trp Pro Gly Asn Asp Arg Leu Leu
690 695 700
Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr
705 710 715 720
Thr Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met
725 730 735
Leu Ala His Tyr Asn Met Gly Phe Gln Gly Tyr Gln Leu Pro Pro Asp
740 745 750
Tyr Lys Asp Arg Thr Phe Ser Phe Leu His Asn Phe Thr Pro Met Cys
755 760 765
Arg Gln Val Pro Asn Pro Ala Asn Glu Gly His Gln Gln Leu Arg Ile
770 775 780
Thr Arg Leu His Asn Asn Ser Gly Phe Ile Gly Phe Asp Thr Gly Ala
785 790 795 800
Gly Ser Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro Tyr Pro Leu
805 810 815
Ile Gly Pro Asp Ala Val Pro Ser Val Thr Gln Arg Lys Phe Leu Cys
820 825 830
Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met
835 840 845
Gly Ser Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ala Ala
850 855 860
His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Ile Asn Glu Pro Thr
865 870 875 880
Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg Val His Gln
885 890 895
Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr Pro Phe Ser
900 905 910
Ala Gly Asn Ala Thr
915
<210> 35
<211> 911
<212> PRT
<213> 树鼩腺病毒（Tree shrew adenovirus）
<400> 35
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Phe Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Glu Ser Tyr Phe Asn Ile Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser
115 120 125
Ala Thr Asn Asn Ala Gln Tyr Thr Ser Gly Gly Lys Thr Ala Thr Tyr
130 135 140
Ala Gln Ala Ser Phe Ile Ser Glu Ile Val Glu Val Gly Gly Gln Tyr
145 150 155 160
Gly Ile Lys Val Gly Glu Asp Asn Thr Gly Ala Asp Ile Leu Ala Asp
165 170 175
Pro Asn Tyr Gln Pro Glu Pro Thr Val Gly Gly Glu Gly Trp Thr Val
180 185 190
Glu Leu Gly Thr Ile Asp Ser Ala Gly Gly Arg Val Leu Ser Ala Thr
195 200 205
Thr Pro Lys Ala Pro Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn Asn
210 215 220
Asn Gly Gly Gln Thr Thr Gly Gln Val Asn Val Lys Phe Phe Lys Glu
225 230 235 240
Gly Gln Gly Ala Gly Asn Pro Thr Val Ala Leu Tyr Ser Glu Thr Val
245 250 255
Asp Met Gln Ser Pro Asp Thr His Leu Val Tyr Ala Thr Glu Pro Gly
260 265 270
Ala Leu Pro Asp Gly Leu Gly Gln Gln Ser Ala Pro Asn Arg Pro Asn
275 280 285
Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser
290 295 300
Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala
305 310 315 320
Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met
325 330 335
Leu Asp Ser Leu Val Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln
340 345 350
Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Val Leu Glu Asn Asn Gly
355 360 365
Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Ser Gly Val Gly
370 375 380
Leu Thr Glu Leu Tyr Thr Gly Val Ala Arg Asn Gly Gly Asn Trp Ala
385 390 395 400
Ala Asp Asn Asp Ala Ala Ala Ser Gln Ile Ala Val Gly Asn Val His
405 410 415
Ala Met Glu Ile Asn Ile Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr
420 425 430
Ser Asn Val Ala Leu Tyr Leu Pro Asp Glu Tyr Lys Tyr Thr Pro Ile
435 440 445
Asn Val Thr Leu Pro Glu Asn Thr Asn Thr Tyr Ala Tyr Met Asn Gly
450 455 460
Arg Val Pro Ala Asn Asn Leu Val Asp Ser Phe Val Asn Val Gly Ala
465 470 475 480
Arg Trp Ser Pro Asp Val Met Asp Asn Val Asn Pro Phe Asn His His
485 490 495
Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg
500 505 510
Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys
515 520 525
Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg
530 535 540
Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg
545 550 555 560
Val Asp Gly Ala Ser Ile Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser
565 570 575
Phe Phe Pro Met Ser His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu
580 585 590
Arg Asn Asp Thr Asn Asp Gln Cys Phe Thr Asp Tyr Leu Ser Ala Ala
595 600 605
Asn Met Leu Tyr Pro Ile Ala Ala Asn Ala Thr Asn Val Pro Ile Ser
610 615 620
Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg
625 630 635 640
Leu Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr
645 650 655
Phe Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu
660 665 670
Asn His Thr Phe Arg Arg Val Ala Ile Gln Phe Asp Ser Ser Val Ser
675 680 685
Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys
690 695 700
Arg Ala Val Asp Gly Glu Gly Tyr Ser Thr Ala Gln Ser Thr Ile Thr
705 710 715 720
Lys Asp Trp Phe Leu Thr Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr
725 730 735
Gln Gly Tyr Tyr Leu Pro Asp Gly Tyr Lys Asp Arg Leu Tyr Ser Phe
740 745 750
Leu Arg Asn Phe Gln Pro Met Cys Arg Gln Val Val Asp Glu Ala Asn
755 760 765
Tyr Ala Asn Tyr Lys Ala Val Ser Ile Thr His Gln His Asn Asn Ser
770 775 780
Gly Phe Thr Gly Phe Ala Ser Ala Ala Val Pro Arg Glu Gly His Pro
785 790 795 800
Tyr Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Asp Thr Ala Val Pro
805 810 815
Ser Val Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile
820 825 830
Pro Phe Ser Ser Asn Phe Met Ser Met Gly Thr Leu Ser Asp Leu Gly
835 840 845
Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Ile Phe
850 855 860
Glu Val Asp Pro Met Pro Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu
865 870 875 880
Val Phe Asp Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu
885 890 895
Val Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905 910
<210> 36
<211> 905
<212> PRT
<213> 犬腺病毒2（Canine adenovirus 2）
<400> 36
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Ala
115 120 125
Gly Ala Asn Asn Cys Leu Phe Asn Gly Gln Gly Ala Asn Ile Asn Thr
130 135 140
Leu Ala Gln Val Pro Ser Ala Gly Ala Ile Thr Val Asn Gly Gln Ala
145 150 155 160
Ala Val Thr Asn Asn Thr Tyr Gln Pro Glu Pro Gln Leu Gly Pro Glu
165 170 175
Ser Trp Val Asp Gly Ser Leu Ala Glu Leu Gly Asp Ala Ser Gly Arg
180 185 190
Ala Leu Lys Ala Ser Thr Pro Arg Met Pro Cys Tyr Gly Ser Tyr Ala
195 200 205
Pro Pro Thr Asn Glu Asn Gly Gly Gln Ala Thr Gly Pro Val Glu Ser
210 215 220
Arg Phe Tyr Lys Val Thr Thr Asn Asn Asn Asn Glu Ala Asp Ala Met
225 230 235 240
Leu Tyr Thr Glu Asp Val Asn Leu Gln Ala Pro Asp Thr His Leu Val
245 250 255
His Gln Val Pro Glu Gly Gln Val Thr Gly Val Gln Gly Leu Gly Gln
260 265 270
Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe
275 280 285
Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala
290 295 300
Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn
305 310 315 320
Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg Ser
325 330 335
Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Gln Asp
340 345 350
Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn Tyr
355 360 365
Cys Tyr Pro Leu Ser Gly Met Gly Pro Leu Thr Asn Met Thr Thr Met
370 375 380
Lys Val Asn Asn Gln Asn Phe Gln Ala Glu Asn Thr Asn Val Gly Pro
385 390 395 400
Ile Gln Lys Ile Gly Phe Gly Asn Val Glu Ala Met Glu Ile Asn Leu
405 410 415
Asn Ala Asn Leu Phe Lys Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr
420 425 430
Leu Pro Asp Ala Phe Lys Tyr Thr Pro Glu Asn Ile Val Ala Pro Ala
435 440 445
Asn Val Asn Thr Tyr Ala Tyr Met Asn Val Arg Leu Pro Ala Ala Asn
450 455 460
Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val
465 470 475 480
Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg
485 490 495
Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile
500 505 510
Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro
515 520 525
Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile
530 535 540
Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Thr Ile
545 550 555 560
Asn Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His
565 570 575
Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Val Asn Asp
580 585 590
Gln Ser Phe Ala Asp Tyr Leu Ser Ser Ala Asn Met Leu Tyr Pro Ile
595 600 605
Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala Arg Asn Trp
610 615 620
Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Arg Glu Thr
625 630 635 640
Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Ser
645 650 655
Ile Pro Tyr Leu Asp Ala Thr Phe Tyr Leu Ser His Thr Phe Arg Arg
660 665 670
Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg
675 680 685
Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Tyr Val Asp Gly Glu
690 695 700
Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Met Val
705 710 715 720
Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro
725 730 735
Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn Phe Glu Pro
740 745 750
Met Cys Arg Gln Leu Val Asp Val Ala Asn Tyr Ala Ala Tyr Gln Pro
755 760 765
Val Thr Val Gly His Gln His Asn Asn Ser Gly Tyr Ala Ser Ala Leu
770 775 780
Ser Ala Phe Asn Pro Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro
785 790 795 800
Tyr Pro Leu Ile Gly Ala Asn Ala Val Pro Thr Val Thr Gln Lys Lys
805 810 815
Phe Leu Cys Asp Arg Ser Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe
820 825 830
Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ser
835 840 845
Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met Asn
850 855 860
Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg
865 870 875 880
Val His Gln Pro His Arg Gly Val Ile Glu Val Gly Tyr Leu Arg Thr
885 890 895
Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905
<210> 37
<211> 905
<212> PRT
<213> 犬腺病毒1（Canine adenovirus 1）
<400> 37
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Arg Ala
115 120 125
Gly Ala Asn Asn Cys Leu Phe Asn Gly Ser Gly Ala Asn Ile Asn Thr
130 135 140
Leu Ala Gln Val Pro Phe Ala Gly Ala Ile Thr Val Asn Gly Gln Ala
145 150 155 160
Ala Val Thr Asp Asn Thr Tyr Gln Pro Glu Pro Gln Leu Gly Pro Glu
165 170 175
Ser Trp Val Asp Gly Thr Leu Ala Asp Leu Gly Asp Ala Ser Gly Arg
180 185 190
Ala Leu Lys Ala Ser Thr Pro Arg Met Pro Cys Tyr Gly Ser Tyr Ala
195 200 205
Pro Pro Thr Asn Glu Asn Gly Gly Gln Ala Thr Gly Ala Val Glu Arg
210 215 220
Arg Phe Tyr Lys Val Thr Thr Asn Asn Asn Asn Glu Ala Asp Ala Leu
225 230 235 240
Leu Tyr Thr Glu Asp Val Asn Leu Gln Thr Pro Asp Thr His Leu Val
245 250 255
His Gln Val Ser Asp Asp Gln Val Thr Gly Val Gln Gly Leu Gly Gln
260 265 270
Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe
275 280 285
Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala
290 295 300
Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn
305 310 315 320
Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg Ser
325 330 335
Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Gln Asp
340 345 350
Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn Tyr
355 360 365
Cys Phe Pro Leu Ser Gly Met Gly Pro Leu Thr Asn Met Thr Ala Met
370 375 380
Lys Val Asn Asn Gln Asn Phe Gln Thr Asp Asn Thr Asn Val Gly Pro
385 390 395 400
Ile Gln Lys Ile Gly Phe Gly Asn Val Glu Ala Met Glu Ile Asn Leu
405 410 415
Asn Ala Asn Leu Phe Lys Gly Phe Leu Tyr Ser Asn Val Ala Leu Tyr
420 425 430
Leu Pro Asp Ala Tyr Lys Tyr Thr Pro Asp Asn Ile Val Ala Pro Ala
435 440 445
Asn Ala Asn Thr Tyr Ala Tyr Met Asn Val Arg Leu Pro Ala Ala Asn
450 455 460
Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val
465 470 475 480
Met Asp Ser Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg
485 490 495
Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile
500 505 510
Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro
515 520 525
Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile
530 535 540
Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile
545 550 555 560
Asn Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His
565 570 575
Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Val Asn Asp
580 585 590
Gln Ser Phe Ala Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile
595 600 605
Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala Arg Asn Trp
610 615 620
Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Arg Glu Thr
625 630 635 640
Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Ser
645 650 655
Ile Pro Tyr Leu Asp Ser Thr Phe Tyr Leu Ser His Thr Phe Arg Arg
660 665 670
Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg
675 680 685
Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Tyr Val Asp Gly Glu
690 695 700
Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val
705 710 715 720
Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro
725 730 735
Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn Phe Glu Pro
740 745 750
Met Cys Arg Gln Leu Val Asp Val Thr Asn Tyr Ala Thr Tyr Gln Ser
755 760 765
Val Thr Val Gly His Gln His Asn Asn Ser Gly Tyr Ala Ser Ala Leu
770 775 780
Ser Thr Phe Asn Pro Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro
785 790 795 800
Tyr Pro Leu Ile Gly Val Asn Ala Val Pro Thr Val Thr Gln Lys Lys
805 810 815
Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe
820 825 830
Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ser
835 840 845
Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met Asn
850 855 860
Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg
865 870 875 880
Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr
885 890 895
Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905
<210> 38
<211> 908
<212> PRT
<213> 蝙蝠腺病毒 TJM（Bat adenovirus TJM）
<400> 38
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Tyr Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ala
115 120 125
Gly Ala Asn Asn Cys Leu Phe Asn Gly Thr Gly Asn Asn Ile Asn Thr
130 135 140
Val Ala Gln Val Thr Thr Leu Gly Asn Ile Thr Val Gln Gly Leu Asn
145 150 155 160
Gly Val Thr Asn Ser Ala Tyr Glu Pro Tyr Pro Gln Gln Gly Pro Glu
165 170 175
Ser Trp Thr Ser Gly Ser Leu Glu Ala Ile Gly Asp Ala Gly Ala Arg
180 185 190
Ala Leu Lys Ala Thr Val Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala
195 200 205
Ala Pro Thr Asn Glu Asn Gly Gly Gln Ser Thr Gly Thr Ile Thr Pro
210 215 220
Ala Tyr Tyr Lys Lys Thr Thr Thr Ala Gly Ala Thr Asp Val Asp Ala
225 230 235 240
Met Leu Tyr Thr Glu Glu Val Ala Leu Gln Ala Pro Asp Thr His Leu
245 250 255
Val Tyr Lys Val Ala Glu Ala Asp Ala Lys Gly Ile Pro Gly Val Gly
260 265 270
Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn
275 280 285
Phe Val Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu
290 295 300
Ala Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg
305 310 315 320
Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg
325 330 335
Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp His
340 345 350
Asp Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn
355 360 365
Tyr Cys Phe Pro Leu Ser Gly Met Gly Val Met Glu Ala Val Ser Ser
370 375 380
Met Lys Val Asn Thr Ala Asn Asn Gly Phe Glu Ala Asn Asn Thr Asn
385 390 395 400
Gln Gly Pro Val Gln Gln Ile Gly Phe Gly Asn Val Asn Ala Met Glu
405 410 415
Ile Asn Leu Asn Ala Asn Leu Phe Lys Gly Phe Leu Tyr Ser Asn Ile
420 425 430
Ala Leu Tyr Leu Pro Asp Asp Tyr Lys Tyr Thr Pro Gln Asn Val Thr
435 440 445
Glu Pro Ala Asn His Asn Thr Tyr Ala Tyr Met Asn Ile Arg Leu Pro
450 455 460
Ala Ala Asn Leu Val Asp Thr Phe Val Asn Val Gly Ala Arg Trp Ser
465 470 475 480
Pro Asp Val Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn Ala
485 490 495
Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser
500 505 510
Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu
515 520 525
Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val
530 535 540
Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly
545 550 555 560
Ala Ser Ile Thr Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro
565 570 575
Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp
580 585 590
Val Asn Asp Gln Thr Phe Ala Asp Tyr Leu Ser Ala Ala Asn Met Leu
595 600 605
Tyr Pro Ile Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala
610 615 620
Arg Asn Trp Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln
625 630 635 640
Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr
645 650 655
Ser Gly Thr Met Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr
660 665 670
Phe Arg Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly
675 680 685
Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val
690 695 700
Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp
705 710 715 720
Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr
725 730 735
His Leu Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn
740 745 750
Phe Glu Pro Met Cys Arg Gln Gln Val Asp Thr Gln Lys Ala Glu Asn
755 760 765
Tyr Gln Ala Val Thr Ile Asn Asn Gln His Asn Asn Ser Gly Tyr Ala
770 775 780
Ser Ala Leu Ser Ala Ser Asn Pro Arg Glu Gly His Pro Tyr Pro Ala
785 790 795 800
Asn Trp Pro Tyr Pro Leu Ile Gly Ala Thr Ala Leu Pro Ser Val Thr
805 810 815
Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser
820 825 830
Ser Asn Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu
835 840 845
Leu Tyr Ser Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp
850 855 860
Glu Met Asn Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp
865 870 875 880
Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr
885 890 895
Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905
<210> 39
<211> 939
<212> PRT
<213> 猪腺病毒3（Porcine adenovirus 3）
<400> 39
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ser
20 25 30
Gln Ala Thr Glu Thr Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Phe Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ile Met Ala Pro Lys Ser
115 120 125
Ala Pro Asn Asn Cys Gln Tyr Leu Asp Pro Lys Gly Glu Thr Glu Ala
130 135 140
Gly Lys Val Asn Thr Ile Ala Gln Ala Ser Phe Val Gly Pro Ile Asp
145 150 155 160
Glu Thr Thr Gly Asp Ile Lys Ile Thr Glu Glu Glu Asp Glu Glu Thr
165 170 175
Thr Ile Asp Pro Leu Tyr Glu Pro Gln Pro Gln Leu Gly Pro Ser Ser
180 185 190
Trp Ser Asp Asn Ile Pro Ser Ala Thr Ser Gly Ala Gly Arg Val Leu
195 200 205
Lys Gln Thr Thr Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala Ser Pro
210 215 220
Thr Asn Ile His Gly Gly Gln Thr Lys Asp Asp Lys Val Thr Pro Leu
225 230 235 240
Tyr Phe Thr Asn Asn Pro Ala Thr Glu Ala Glu Ala Leu Glu Glu Asn
245 250 255
Gly Leu Lys Pro Asn Val Thr Leu Tyr Ser Glu Asp Val Asp Leu Lys
260 265 270
Ala Pro Asp Thr His Leu Val Tyr Ala Val Asn Gln Thr Gln Glu Phe
275 280 285
Ala Gln Tyr Gly Leu Gly Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr
290 295 300
Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn
305 310 315 320
Gly Asn Gln Gly Met Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val
325 330 335
Val Asp Leu Gln Asp Arg Asn His Arg Thr Ser Tyr Gln Leu Phe Leu
340 345 350
Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Gly
355 360 365
Ile Asp Ser Tyr Asp Lys Asp Val Arg Val Leu Gly Asn Asn Gly Val
370 375 380
Glu Asp Glu Met Pro Asn Phe Cys Phe Pro Ile Gly Ala Ile Glu Thr
385 390 395 400
Asn Met Thr Phe Thr Gln Leu Lys Lys Ser Glu Asn Gly Gly Ser Arg
405 410 415
Ala Thr Thr Trp Thr Lys Glu Asn Gly Asp Asp Gly Gly Asn Gly Ala
420 425 430
Glu His Tyr Leu Gly Ile Gly Asn Leu Asn Ala Met Glu Ile Asn Leu
435 440 445
Thr Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr
450 455 460
Leu Pro Asp Lys Tyr Lys Phe Ser Pro Pro Asn Val Pro Ile Asp Pro
465 470 475 480
Asn Thr His Ser Tyr Asp Tyr Ile Asn Lys Arg Leu Pro Leu Asn Asn
485 490 495
Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val
500 505 510
Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly Leu Arg
515 520 525
Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile
530 535 540
Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Ser Leu Leu Leu Leu Pro
545 550 555 560
Gly Ala Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met
565 570 575
Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Lys
580 585 590
Ile Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala
595 600 605
His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn
610 615 620
Asn Gln Thr Phe Ile Asp Phe Leu Ser Ser Ala Asn Met Leu Tyr Pro
625 630 635 640
Ile Pro Ala Asn Val Thr Asn Leu Pro Ile Ser Ile Pro Ser Arg Asn
645 650 655
Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys His Asn Glu
660 665 670
Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr Ser Gly
675 680 685
Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Gly His Thr Phe Arg
690 695 700
Arg Ile Ser Ile Gln Phe Asp Ser Ser Val Ala Trp Pro Gly Asn Asp
705 710 715 720
Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Thr Val Asp Gly
725 730 735
Glu Gly Tyr Thr Val Ala Gln Thr Asn Met Thr Lys Asp Trp Phe Leu
740 745 750
Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu
755 760 765
Pro Glu Gly Tyr Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Glu
770 775 780
Pro Met Cys Arg Gln Val Pro Asp Tyr Ala Asn His Lys Asp Glu Tyr
785 790 795 800
Leu Glu Val Pro Thr Thr Asn Gln Phe Asn Ser Ser Gly Phe Val Ser
805 810 815
Ala Ala Phe Thr Ala Gly Ile Ala Gln Gly His Pro Tyr Pro Ala Asn
820 825 830
Trp Pro Tyr Pro Leu Ile Gly Glu Asp Ala Val Gln Thr Val Thr Gln
835 840 845
Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser
850 855 860
Asn Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu
865 870 875 880
Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala
885 890 895
Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val
900 905 910
Cys Gly Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu
915 920 925
Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
930 935
<210> 40
<211> 938
<212> PRT
<213> 猪腺病毒3（Porcine adenovirus 3）
<400> 40
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ser
20 25 30
Gln Ala Thr Glu Thr Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Phe Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ile Met Ala Pro Lys Ser
115 120 125
Ala Pro Asn Asn Cys Gln Tyr Leu Asp Pro Lys Gly Glu Thr Glu Ala
130 135 140
Gly Lys Val Asn Thr Ile Ala Gln Ala Ser Phe Val Gly Pro Ile Asp
145 150 155 160
Glu Thr Thr Gly Asp Ile Lys Ile Thr Glu Glu Glu Asp Glu Glu Thr
165 170 175
Thr Ile Asp Pro Leu Tyr Glu Pro Gln Pro Gln Leu Gly Pro Ser Ser
180 185 190
Trp Ser Asp Asn Ile Pro Ser Ala Thr Ser Gly Ala Gly Arg Val Leu
195 200 205
Lys Gln Thr Thr Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala Ser Pro
210 215 220
Thr Asn Ile His Gly Gly Gln Thr Lys Asp Asp Lys Val Thr Pro Leu
225 230 235 240
Tyr Phe Thr Asn Asn Pro Ala Thr Glu Ala Glu Ala Leu Glu Glu Asn
245 250 255
Gly Leu Lys Pro Asn Val Thr Leu Tyr Ser Glu Asp Val Asp Leu Lys
260 265 270
Ala Pro Asp Thr His Leu Val Tyr Ala Val Asn Gln Thr Gln Glu Phe
275 280 285
Ala Gln Tyr Gly Leu Gly Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr
290 295 300
Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn
305 310 315 320
Gly Asn Gln Gly Met Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val
325 330 335
Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Phe Leu
340 345 350
Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala
355 360 365
Ile Asp Ser Tyr Asp Lys Asp Val Arg Val Leu Glu Asn Asn Gly Val
370 375 380
Glu Asp Glu Met Pro Asn Phe Cys Phe Pro Ile Gly Ala Ile Glu Thr
385 390 395 400
Asn Met Thr Phe Thr Gln Leu Lys Lys Ser Glu Asn Gly Gly Ser Arg
405 410 415
Ala Thr Thr Trp Thr Lys Glu Asn Gly Asp Asp Gly Gly Asn Gly Ala
420 425 430
Glu His Tyr Leu Gly Ile Gly Asn Leu Asn Ala Met Glu Ile Asn Leu
435 440 445
Thr Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr
450 455 460
Leu Pro Asp Lys Tyr Lys Phe Ser Pro Pro Asn Val Pro Ile Asp Pro
465 470 475 480
Asn Thr His Ser Tyr Asp Tyr Ile Asn Lys Arg Leu Pro Leu Asn Asn
485 490 495
Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val
500 505 510
Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly Leu Arg
515 520 525
Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile
530 535 540
Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Ser Leu Leu Leu Leu Pro
545 550 555 560
Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile
565 570 575
Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Lys Ile
580 585 590
Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His
595 600 605
Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asn
610 615 620
Gln Thr Phe Ile Asp Phe Leu Ser Ser Ala Asn Met Leu Tyr Pro Ile
625 630 635 640
Pro Ala Asn Val Thr Asn Leu Pro Ile Ser Ile Pro Ser Arg Asn Trp
645 650 655
Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys His Asn Glu Thr
660 665 670
Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr Ser Gly Ser
675 680 685
Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Gly His Thr Phe Arg Arg
690 695 700
Ile Ser Ile Gln Phe Asp Ser Ser Val Ala Trp Pro Gly Asn Asp Arg
705 710 715 720
Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Thr Val Asp Gly Glu
725 730 735
Gly Tyr Thr Val Ala Gln Thr Asn Met Thr Lys Asp Trp Phe Leu Val
740 745 750
Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro
755 760 765
Glu Gly Tyr Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Glu Pro
770 775 780
Met Cys Arg Gln Val Pro Asp Tyr Ala Asn His Lys Asp Glu Tyr Leu
785 790 795 800
Glu Val Pro Thr Thr Asn Gln Phe Asn Ser Ser Gly Phe Val Ser Ala
805 810 815
Ala Phe Thr Ala Gly Met Arg Glu Gly His Pro Tyr Pro Ala Asn Trp
820 825 830
Pro Tyr Pro Leu Ile Gly Glu Asp Ala Val Gln Thr Val Thr Gln Arg
835 840 845
Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn
850 855 860
Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr
865 870 875 880
Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met
885 890 895
Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Cys
900 905 910
Gly Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg
915 920 925
Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
930 935
<210> 41
<211> 914
<212> PRT
<213> 牛腺病毒10（Bovine adenovirus 10）
<400> 41
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Ala Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Asp Ser Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Thr Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Val Ile Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Asn Leu Ala Pro Arg Ser
115 120 125
Ala Pro Asn Asn Cys Phe Phe Lys Asn Asp Asn Gly Gly His Pro Asp
130 135 140
Val Ala Tyr Ala Gln Leu Pro Phe Val Gly Thr Arg Glu Gln Gln Asn
145 150 155 160
Leu Met Val Leu Asn Ala Glu Gly Gln Arg Val Ala Ala Asp Pro Ile
165 170 175
Tyr Gln Pro Glu Pro Gln Tyr Gly Val Asp Ala Trp Pro Gln Asn Arg
180 185 190
Leu Gly Asp Phe Asn Ala Gly Arg Ala Leu Lys Ser Asp Val Thr His
195 200 205
Leu Pro Cys Tyr Gly Ser Tyr Ala Ser Pro Thr Asn Ile His Gly Gly
210 215 220
Gln Ser Thr Asp Asp Asp Ile Thr Lys Val Phe Phe Arg Arg Glu Asn
225 230 235 240
Ala Ala Gly Ala Pro Glu Gly Val Leu Tyr Ser Glu Thr Val Ala Leu
245 250 255
Glu Gln Pro Asp Thr His Leu Ser Phe Lys Val Thr Ala Asp Gln Thr
260 265 270
Thr Lys Leu Leu Gly Leu Ala Gln Gln Ala Cys Pro Asn Arg Pro Asn
275 280 285
Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser
290 295 300
Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ser
305 310 315 320
Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met
325 330 335
Leu Asp Asn Leu Tyr Asp Arg Ser Thr Tyr Phe Ser Leu Trp Asn Gln
340 345 350
Ala Ile Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly
355 360 365
Val Glu Asp Glu Ile Pro Ala Phe Cys Phe Pro Ile Ser Ala Ile Gln
370 375 380
Thr Thr Val Phe Tyr Thr Gln Met Lys Thr Asp Asp Asn Gly Asn Asn
385 390 395 400
Trp Thr Pro Val Asp Asn Ala Thr Gln Asn Gln Tyr Val Asp Arg Gly
405 410 415
Asn Leu Gln Cys Met Glu Val Asn Ile Ser Gly Asn Leu Trp Arg Ser
420 425 430
Phe Leu Tyr Ser Asn Val Gly Leu Tyr Leu Pro Asp Arg Leu Lys Phe
435 440 445
Thr Pro Glu Asn Val Glu Glu Pro Glu Asn His Asp Thr Tyr Asp Tyr
450 455 460
Met Asn Ile Arg Ile Pro Pro Ser Gly Leu Val Glu Asn Tyr Ile Asn
465 470 475 480
Ile Gly Ala Arg Trp Ser Leu Asp Ile Met Asp Asn Val Asn Pro Phe
485 490 495
Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly
500 505 510
Asn Gly Arg Tyr Cys Glu Phe His Ile Gln Val Pro Gln Lys Phe Phe
515 520 525
Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr Glu Trp
530 535 540
Ser Phe Arg Lys Asp Val Asn Met Ile Phe Gln Ser Ser Leu Gly Asn
545 550 555 560
Asp Leu Arg Val Asp Gly Ala Lys Ile Thr Ile Glu Ser Val Asn Leu
565 570 575
Tyr Ala Ser Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu
580 585 590
Ala Met Leu Arg Asn Glu Thr Asn Asp Gln Thr Phe Asn Asp Tyr Leu
595 600 605
Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro Gln Thr Ser Asn Val
610 615 620
Pro Ile Thr Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser
625 630 635 640
Phe Thr Arg Leu Lys Ala Lys Glu Thr Pro Ala Leu Gly Ser Pro Tyr
645 650 655
Asp Pro Tyr Phe Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr
660 665 670
Phe Tyr Leu Asn His Thr Phe Arg Lys Val Ala Ile Gln Phe Asp Ser
675 680 685
Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Ser Pro Asn Glu Phe
690 695 700
Glu Ile Lys Arg Gln Val Asp Gly Glu Gly Tyr Asn Ile Ala Gln Ser
705 710 715 720
Asn Met Thr Lys Asp Trp Phe Leu Thr Gln Met Leu Cys His Tyr Asn
725 730 735
Ile Gly Tyr Gln Gly Tyr His Leu Pro Asp Ser Tyr Lys Asp Arg Thr
740 745 750
Tyr Ser Phe Leu Lys Asn Phe Gln Pro Met Cys Arg Gln Ile Val Thr
755 760 765
Ala Asn Thr Phe Asp Asn Tyr Lys Ala Val Thr Ile Ala Asn Gln His
770 775 780
Asn Asn Ser Gly Phe Ile Gly Phe Pro Asn Pro Val Ser Ala Arg Glu
785 790 795 800
Gly His Pro Tyr Pro Ala Asn Trp Pro Tyr Pro Ile Ile Gly Thr Thr
805 810 815
Ala His Arg Ala Glu Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu
820 825 830
Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr
835 840 845
Asp Leu Gly Gln Asn Leu Leu Tyr Ser Asn Ser Ala His Ala Leu Asp
850 855 860
Met Thr Phe Glu Val Glu Pro Met Asp Glu Pro Thr Leu Leu Tyr Val
865 870 875 880
Leu Phe Glu Val Phe Asp Val Cys Arg Ile His Gln Pro His Arg Gly
885 890 895
Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ala Ala Gly Asn Ala
900 905 910
Thr Thr
<210> 42
<211> 908
<212> PRT
<213> 绵羊腺病毒1（Ovine adenovirus 1）
<400> 42
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ala
115 120 125
Ser Val Asn Asn Thr Phe Phe Thr Ala Ala Ala Asn Asn Asn Ala Gln
130 135 140
Ala Ile Ala Gln Ala Pro Phe Val Ala Glu Ile Val Ala Asn Thr Gly
145 150 155 160
Glu Ile Glu Ile Asp Gly Glu Pro Ile Asp Asn Thr Tyr Gln Pro Glu
165 170 175
Pro Gln Leu Gly Glu Glu Ser Trp Leu Ser Gly Thr Ile Asn Pro Ile
180 185 190
Asn Glu Ala Thr Gly Arg Ile Leu Asn Thr Asn Thr Asp Pro Leu Pro
195 200 205
Cys Tyr Gly Ser Tyr Ala Asn Pro Thr Asn Lys Asp Gly Gly Gln Ala
210 215 220
Thr Gly Asn Lys Leu Thr Val Asn Phe Lys Leu Gly Asn Gln Ala Gly
225 230 235 240
Asp Pro Asp Thr Ala Phe Ile Met Glu Asp Val Asn Leu Thr Ala Pro
245 250 255
Asp Ser His Leu Val Tyr Lys Val Pro Gln Asp Gln Ala Gly Lys Ile
260 265 270
Ala Ala Val Ala Gln Gln Ala Gly Pro Asn Arg Pro Asn Tyr Ile Gly
275 280 285
Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn
290 295 300
Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp
305 310 315 320
Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser
325 330 335
Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Ile Trp Asn Gln Ala Val Asp
340 345 350
Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp
355 360 365
Glu Met Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Phe Pro Gly Ser
370 375 380
Pro Ser Val Arg Val Thr Arg Gln Gln Asn Ala Trp Ala Lys Ala Pro
385 390 395 400
Gly Thr Glu Asp Asn Asn Tyr Ile Asn Lys Gly Asn Leu Glu Cys Met
405 410 415
Glu Ile Asn Leu Asn Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn
420 425 430
Val Ala Leu Tyr Leu Pro Asp Ala Leu Lys Phe Thr Pro Pro Asn Val
435 440 445
Thr Leu Pro Gln Asn Gln Asn Thr Tyr Ala Tyr Met Asn Gly Arg Ile
450 455 460
Pro Ala Gly Gly Leu Val Asp Thr Phe Val Asn Ile Gly Ala Arg Trp
465 470 475 480
Ser Leu Asp Val Met Asp Asn Ile Asn Pro Phe Asn His His Arg Asn
485 490 495
Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys
500 505 510
Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu
515 520 525
Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp
530 535 540
Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp
545 550 555 560
Gly Ala Ser Ile Thr Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe Phe
565 570 575
Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn
580 585 590
Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn Met
595 600 605
Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Leu Pro Ile Ser Ile Pro
610 615 620
Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys
625 630 635 640
Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr
645 650 655
Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His
660 665 670
Thr Phe Arg Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp Pro
675 680 685
Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Met
690 695 700
Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp
705 710 715 720
Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly
725 730 735
Tyr His Leu Pro Asp Ser Tyr Lys Asp Arg Thr Tyr Ser Phe Leu Arg
740 745 750
Asn Phe Glu Pro Met Ser Arg Gln Val Val Asp Ile Ala Asn Tyr Ala
755 760 765
Ala Tyr Gln Asp Val Pro Leu Thr His Gln His Asn Asn Ser Gly Phe
770 775 780
Thr Gly Phe Gly Ser Ala Ala Leu Pro Arg Glu Gly His Pro Tyr Pro
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Ile Gly Ala Asn Ala Ala Pro Thr Leu
805 810 815
Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe
820 825 830
Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn
835 840 845
Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val
850 855 860
Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe
865 870 875 880
Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val
885 890 895
Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr
900 905
<210> 43
<211> 908
<212> PRT
<213> 牛腺病毒1（Bovine adenovirus 1）
<400> 43
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr His
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly
115 120 125
Ser Ile Asn Asn Thr Phe Val Ser Val Ala Gly Asn Asn Asn Ala Lys
130 135 140
Ala Phe Ala Gln Ala Pro Gln Ser Ala Thr Val Asp Gly Thr Thr Gly
145 150 155 160
Ala Ile Gln Ile Asp Gly Ala Ala Ile Asp Asn Thr Tyr Gln Pro Glu
165 170 175
Pro Gln Lys Gly Glu Glu Ser Trp Leu Ser Gly Thr Val Asn Pro Ile
180 185 190
Ala Gln Ala Thr Gly Arg Ile Leu Asn Thr Ser Thr Asp Pro Leu Pro
195 200 205
Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn Ile Glu Gly Ala Gln Thr
210 215 220
Leu Asn Asn Asn Leu Ile Gln Val Asn Phe Val Ala Gly Gly Ala Pro
225 230 235 240
Gly Ala Pro Asp Val Gly Met Ile Met Glu Asp Val Ala Leu Gln Thr
245 250 255
Pro Asp Thr His Leu Val Tyr Lys Val Pro Ala Ala Asn Val Gly Asn
260 265 270
Thr Ala Ala Leu Ala Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr Ile
275 280 285
Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly
290 295 300
Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val
305 310 315 320
Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp
325 330 335
Asn Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Ile Trp Asn Gln Ala Val
340 345 350
Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu
355 360 365
Asp Glu Leu Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Val Pro Gly
370 375 380
Thr Thr Ser Thr Arg Val Thr Arg Asn Gly Gly Asn Trp Glu Ala Thr
385 390 395 400
Ala Asn Asn Asp Pro Ala Tyr Val Asn Lys Gly Asn Leu Asp Cys Met
405 410 415
Glu Ile Asn Leu Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn
420 425 430
Val Ala Leu Tyr Leu Pro Asp Asp Leu Lys Phe Thr Pro Pro Asn Val
435 440 445
Thr Leu Pro Asn Asn Thr Asn Thr Tyr Ala Tyr Met Asn Gly Arg Val
450 455 460
Pro Ala Ala Gly Leu Val Asp Thr Tyr Val Asn Ile Gly Ala Arg Trp
465 470 475 480
Ser Leu Asp Val Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn
485 490 495
Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys
500 505 510
His Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu
515 520 525
Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp
530 535 540
Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp
545 550 555 560
Gly Ala Ser Ile Thr Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe
565 570 575
Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn
580 585 590
Asp Thr Asn Asp Gln Ser Phe Ile Asp Tyr Leu Ser Ser Ala Asn Met
595 600 605
Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Leu Pro Ile Ser Ile Pro
610 615 620
Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys
625 630 635 640
Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr
645 650 655
Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His
660 665 670
Thr Phe Arg Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp Pro
675 680 685
Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Leu
690 695 700
Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp
705 710 715 720
Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly
725 730 735
Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu Arg
740 745 750
Asn Phe Gln Pro Met Thr Arg Gln Ile Val Asp Gln Thr Asn Val Pro
755 760 765
Ala Tyr Gln Asn Val Pro Ile Thr His Gln His Asn Asn Ser Gly Phe
770 775 780
Thr Gly Phe Ala Ser Pro Ala Leu Pro Arg Glu Gly His Pro Tyr Pro
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Ile Ser Ala Thr Ala Val Ala Thr Gln
805 810 815
Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe
820 825 830
Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn
835 840 845
Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val
850 855 860
Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe
865 870 875 880
Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val
885 890 895
Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr
900 905
<210> 44
<211> 910
<212> PRT
<213> 绵羊腺病毒2（Ovine adenovirus 2）
<400> 44
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala
115 120 125
Ser Val Asn Asn Thr Leu Phe Ile Ala Thr Thr Gly Ala Lys Pro Gln
130 135 140
Ala Ile Ala Gln Ala Ser Phe Glu Ala Thr Val Asn Asp Asn Thr Gly
145 150 155 160
Ala Ile Glu Leu Asp Gly Gln Gln Ile Asn Leu Ser Tyr Gln Pro Ser
165 170 175
Pro Gln Leu Gly Glu Glu Ser Trp Leu Gly Asp Asp Phe Asn Pro Ile
180 185 190
Lys Glu Gly Thr Gly Arg Ile Leu Asp Val Asn Thr Lys Pro Leu Pro
195 200 205
Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Ile Asn Gly Gly Gln Gly
210 215 220
Leu Ala Glu Pro Thr Thr Ile Asn Phe Lys Thr Gly Asn Ala Pro Asp
225 230 235 240
Ile Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Ala Leu Gln Ala Pro
245 250 255
Asp Thr His Leu Val Tyr Lys Val Ala Asn Asp Lys Ser Gly Lys Thr
260 265 270
Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly
275 280 285
Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn
290 295 300
Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp
305 310 315 320
Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser
325 330 335
Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile Asp
340 345 350
Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp
355 360 365
Glu Met Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Lys Leu Glu Glu
370 375 380
Thr Ser Met Arg Val Val Arg Asn Pro Gly Asn Asn Gly Trp Ile Gly
385 390 395 400
Asp Asn Asp Ala Asn Gly Asn Asn Tyr Ile Asn Ile Gly Asn Met Asp
405 410 415
Cys Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr
420 425 430
Ser Asn Ile Ala Leu Tyr Leu Pro Asp Asp Tyr Lys Phe Thr Pro Ala
435 440 445
Asn Val Thr Leu Pro Glu Asn Thr Asn Thr Tyr Glu Tyr Leu Asn Gly
450 455 460
Arg Ile Pro Ala Gly Gly Leu Val Asp Thr Tyr Val Asn Ile Gly Ala
465 470 475 480
Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn Pro Phe Asn His His
485 490 495
Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg
500 505 510
Tyr Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys
515 520 525
Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg
530 535 540
Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg
545 550 555 560
Val Asp Gly Ala Ser Ile Thr Ile Asp Ser Val Asn Leu Tyr Ala Ser
565 570 575
Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu
580 585 590
Arg Asn Asp Thr Asn Asp Gln Ser Phe Ile Asp Tyr Leu Ser Ser Ala
595 600 605
Asn Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr
610 615 620
Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg
625 630 635 640
Ile Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr
645 650 655
Phe Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu
660 665 670
Ser His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln
675 680 685
Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys
690 695 700
Arg Val Val Asp Gly Glu Gly Tyr Gly Val Ala Gln Ser Asn Met Thr
705 710 715 720
Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr
725 730 735
Gln Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe
740 745 750
Leu Arg Asn Phe Gln Pro Met Cys Arg Gln Met Val Asp Ser Thr Arg
755 760 765
Tyr Gln Ala Cys Gln Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser
770 775 780
Gly Phe Thr Ala Phe Ala Asn Ala Ser Leu Pro Arg Glu Gly His Pro
785 790 795 800
Tyr Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro
805 810 815
Cys Thr Thr Gln Lys Lys Phe Leu Cys Asp Lys Thr Leu Trp Arg Ile
820 825 830
Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly
835 840 845
Gln Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe
850 855 860
Glu Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu
865 870 875 880
Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu
885 890 895
Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr
900 905 910
<210> 45
<211> 909
<212> PRT
<213> 绵羊腺病毒3（Ovine adenovirus 3）
<400> 45
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala
115 120 125
Ser Val Asn Asn Thr Leu Ile Ile Ser Asn Asp Ala Asn Lys Pro Gln
130 135 140
Ala Ile Gly Gln Ala Ser Tyr Asp Cys Glu Ile Asn Asp Asp Thr Gly
145 150 155 160
Ala Ile Glu Ile Gly Gly Gln Asn Pro Thr Asp Leu Ala Tyr Gln Pro
165 170 175
Asn Pro Gln Ile Gly Gln Glu Thr Trp Val Phe Asp Asn Phe Gly Lys
180 185 190
Met Thr Gln Gly Ala Gly Arg Met Leu Asn Thr Asp Thr Lys Pro Leu
195 200 205
Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asn Gly Gly Gln
210 215 220
Gly Leu Ala Gln Pro Thr Thr Ile Asn Phe Ala Ser Gly Asp Gln Ala
225 230 235 240
Asp Thr Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Asn Leu Gln Ala
245 250 255
Pro Asp Thr His Leu Val Tyr Lys Val Ala Ala Asp Lys Val Gly Lys
260 265 270
Thr Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile
275 280 285
Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly
290 295 300
Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val
305 310 315 320
Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp
325 330 335
Ser Leu His Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile
340 345 350
Asp Ser Tyr Asp Thr Asp Val Arg Ile Met Glu Asn His Gly Val Glu
355 360 365
Asp Glu Met Pro Asn Tyr Cys Phe Pro Val Ser Gly Ile Gln Thr Leu
370 375 380
Ser Thr Ala Thr Lys Val Lys Lys Gly Ala Ala Asp Trp Glu Thr Asp
385 390 395 400
Thr Asp Ala Asn Gly Val Asn Tyr Ile Thr Leu Gly Asn Leu Asn Cys
405 410 415
Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr Ser
420 425 430
Asn Ile Ala Leu Tyr Leu Pro Asp Glu Phe Lys Phe Thr Pro Glu Asn
435 440 445
Val Asp Leu Pro Glu Asn Lys Asn Thr Tyr Ala Tyr Met Asn Gly Arg
450 455 460
Leu Pro Ala Gly Gly Leu Ile Asp Thr Tyr Val Asn Ile Gly Ala Arg
465 470 475 480
Trp Ser Pro Asp Val Met Asp Val Val Asn Pro Phe Asn His His Arg
485 490 495
Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr
500 505 510
Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Asn
515 520 525
Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys
530 535 540
Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val
545 550 555 560
Asp Gly Ala Ser Ile Asn Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe
565 570 575
Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg
580 585 590
Asn Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn
595 600 605
Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr Ile
610 615 620
Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu
625 630 635 640
Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe
645 650 655
Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser
660 665 670
His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp
675 680 685
Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg
690 695 700
Ala Val Asp Gly Glu Gly Tyr Ser Val Ala Gln Ser Asn Met Thr Lys
705 710 715 720
Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln
725 730 735
Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu
740 745 750
Arg Asn Phe Gln Pro Met Cys Arg Gln Ile Val Asp Ser Thr Arg Tyr
755 760 765
Asp Ala Tyr Lys Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser Gly
770 775 780
Phe Thr Ala Phe Ala Asn Ser Ser Leu Pro Gly Glu Gly His Pro Tyr
785 790 795 800
Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro Cys
805 810 815
Thr Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro
820 825 830
Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln
835 840 845
Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu
850 855 860
Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val
865 870 875 880
Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr
885 890 895
Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr
900 905
<210> 46
<211> 910
<212> PRT
<213> 牛腺病毒2（Bovine adenovirus 2）
<400> 46
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala
115 120 125
Ser Val Asn Asn Thr Leu Ile Ile Ser Asn Asp Ala Asn Lys Pro Gln
130 135 140
Ala Ile Gly Gln Ala Ser Tyr Asp Cys Ala Ile Asn Asp Asp Thr Gly
145 150 155 160
Ala Ile Glu Ile Gly Gly Pro Asn Pro Thr Asp Leu Ala Tyr Gln Pro
165 170 175
Asn Pro Gln Ile Gly Gln Glu Thr Trp Val Phe Asp Asn Phe Gly Lys
180 185 190
Met Thr Gln Gly Ala Gly Arg Met Leu Asn Thr Asp Thr Lys Pro Leu
195 200 205
Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asn Gly Gly Gln
210 215 220
Gly Leu Ala Gln Pro Thr Thr Ile Asn Phe Val Ser Gly Asp Gln Ala
225 230 235 240
Asp Thr Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Asn Leu Gln Ala
245 250 255
Pro Asp Thr His Leu Val Tyr Lys Val Ala Ala Asp Lys Val Gly Lys
260 265 270
Thr Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile
275 280 285
Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly
290 295 300
Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val
305 310 315 320
Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp
325 330 335
Ser Leu His Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile
340 345 350
Asp Ser Tyr Asp Thr Asp Val Arg Ile Met Glu Asn His Gly Val Glu
355 360 365
Asp Glu Met Pro Asn Tyr Cys Phe Pro Val Ser Gly Ile Gln Thr Leu
370 375 380
Ser Lys Ala Thr Lys Val Lys Lys Gly Val Ala Asn Trp Glu Thr Asp
385 390 395 400
Thr Asp Ala Asn Gly Val Asn Tyr Ile Thr Leu Gly Asn Leu Asn Cys
405 410 415
Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr Ser
420 425 430
Asn Ile Ala Leu Tyr Leu Pro Asp Glu Phe Lys Phe Thr Pro Glu Asn
435 440 445
Val Asp Leu Pro Glu Asn Lys Asn Thr Tyr Ala Tyr Met Asn Gly Arg
450 455 460
Leu Pro Ala Gly Gly Leu Ile Asp Thr Tyr Val Asn Ile Gly Ala Arg
465 470 475 480
Trp Ser Pro Asp Val Asn Gly Arg Cys Lys Pro Ile Tyr His His Arg
485 490 495
Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr
500 505 510
Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Asn
515 520 525
Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys
530 535 540
Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val
545 550 555 560
Asp Gly Ala Ser Ile Lys Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe
565 570 575
Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg
580 585 590
Asn Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn
595 600 605
Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr Ile
610 615 620
Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu
625 630 635 640
Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe
645 650 655
Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser
660 665 670
His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp
675 680 685
Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg
690 695 700
Ala Val Asp Gly Glu Gly Tyr Ser Val Ala Gln Ser Asn Met Thr Lys
705 710 715 720
Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln
725 730 735
Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu
740 745 750
Arg Asn Phe Gln Pro Met Cys Arg Gln Ile Val Asp Ala Thr Arg Tyr
755 760 765
Asn Asp Tyr Lys Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser Gly
770 775 780
Phe Thr Ala Phe Ala Asn Ala Ser Leu Pro Arg Glu Gly His Pro Tyr
785 790 795 800
Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro Cys
805 810 815
Ala Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro
820 825 830
Phe Ser Ser Asn Phe Met Ser Met Gly Ser Phe Thr Asp Leu Gly Gln
835 840 845
Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu
850 855 860
Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val
865 870 875 880
Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr
885 890 895
Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905 910
<210> 47
<211> 920
<212> PRT
<213> 羊驼腺病毒 CA/2007（Alpaca adenovirus CA/2007）
<400> 47
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu
50 55 60
Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Leu Leu Asp Met
85 90 95
Gly Ser Ser Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser
115 120 125
Ser Val Asn Asn Cys Gly Phe Thr Ser Ala Ala Asp Leu Pro Gln Tyr
130 135 140
Ile Ala Gln Ala Ser Phe Ile Asn Asp Ile Asn Thr Asn Thr Gly Glu
145 150 155 160
Met Gln Val Gly Glu Asn Asp Gln Gly Gln Pro Val Tyr Ala Asp Lys
165 170 175
Thr Tyr Gln Pro Glu Pro Gln Ile Gly Asn Gln Ser Trp Ser Gln Gly
180 185 190
Pro Gln Asn Thr Leu Leu Ala Asp Ile Glu Gly Ala Gly Arg Ala Leu
195 200 205
Lys Pro Thr Thr Pro Arg Asn Pro Cys Tyr Gly Ser Tyr Ala Ala Pro
210 215 220
Thr Asn Glu Asn Gly Ala Gln Ala Thr Gly Glu Val Asp Leu Val Phe
225 230 235 240
Leu Thr Gln Gly Asn Thr Ala Gly Pro Pro Thr Ser Val Leu Tyr Thr
245 250 255
Glu Asp Val Ala Leu Thr Ala Pro Asp Thr His Phe Val Tyr Lys Val
260 265 270
Ala Asp Asp Asp Leu Ala Thr Ala Pro Gly Leu Gly Gln Gln Ala Ala
275 280 285
Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu
290 295 300
Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala
305 310 315 320
Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu
325 330 335
Ser Tyr Gln Leu Met Leu Asp Asn Leu Tyr Asp Arg Ser Arg Tyr Phe
340 345 350
Ser Ile Trp Asn Gln Ala Ile Asp Ser Tyr Asp Gln Asp Val Arg Val
355 360 365
Leu Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro
370 375 380
Leu Ser Gly Val Leu Tyr Thr Thr Pro Thr Ser Met Gln Val Val Arg
385 390 395 400
Gly Ala Asp Gln Asn Asp Gly Trp Ile Ala Asn Asn Ala Gly Ser Gly
405 410 415
Ile Asn Tyr Ile Asn Asn Gly Asn Leu Asp Cys Met Glu Ile Asn Leu
420 425 430
Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Ile Ala Leu Tyr
435 440 445
Leu Pro Asp Asn Leu Lys Phe Thr Pro Asn Asn Val Ile Leu Ser Asn
450 455 460
Asn Pro Asn Thr Tyr Asn Tyr Met Asn Gly Arg Ile Pro Ala Ala Gly
465 470 475 480
Leu Val Asp Ser Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val
485 490 495
Met Asp Ser Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg
500 505 510
Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile
515 520 525
Gln Val Pro Gln Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro
530 535 540
Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile
545 550 555 560
Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile
565 570 575
Ile Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His
580 585 590
Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp
595 600 605
Gln Ser Phe Ile Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile
610 615 620
Pro Ala Gly Ala Thr Asn Ile Pro Ile Ser Ile Pro Ser Arg Asn Trp
625 630 635 640
Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Lys Glu Thr
645 650 655
Pro Ala Leu Gly Ser Ala Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Thr
660 665 670
Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Arg Arg
675 680 685
Leu Ala Ile Gln Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg
690 695 700
Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Val Val Asp Gly Glu
705 710 715 720
Gly Tyr Asn Val Ala Gln Ser Asn Met Ser Lys Asp Trp Phe Leu Ile
725 730 735
Gln Met Leu Thr Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Leu Pro
740 745 750
Glu Gly Phe Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Gln Pro
755 760 765
Met Cys Arg Gln Val Val Asp Thr Asp Asn Phe Ala Asp Tyr Lys Pro
770 775 780
Val Gln Leu Gln His Gln His Asn Asn Ser Gly Phe Thr Gly Phe Ala
785 790 795 800
Ala Ala Ser Ala Ala Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro
805 810 815
Tyr Pro Leu Ile Gly Glu Asn Ala Val Arg Thr Thr Thr Gln Lys Lys
820 825 830
Phe Leu Cys Asp Arg Thr Leu Trp Ser Ile Pro Phe Ser Ser Asn Phe
835 840 845
Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala
850 855 860
Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Leu Asp
865 870 875 880
Glu Ala Thr Leu Leu Tyr Val Leu Phe Gln Val Phe Asp Val Cys Arg
885 890 895
Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr
900 905 910
Pro Phe Ser Ala Gly Asn Ala Thr
915 920
<210> 48
<211> 909
<212> PRT
<213> 小鼠腺病毒1（Murine adenovirus 1）
<400> 48
Met Thr Thr Pro Ser Met Gln Pro Gln Trp Ala Phe Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Gln Tyr Leu Ser Pro Gly Val Val Gln Phe Ala
20 25 30
Ala Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Ile Val Pro Val Asp Arg Glu Asp Ser Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ser Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ala
115 120 125
Ala Pro Asn Asn Leu Met Phe Lys Thr Gly Ala Asp Ser Lys Thr Met
130 135 140
Thr Ile Ala Gln Ala Asn Ile Val Gly Ser Thr Ile Asp Gln Asp Gly
145 150 155 160
Leu Lys Ile Asn Asn Val Ala Leu Asn Pro Asn Ala Gly Glu Pro Ala
165 170 175
Val Gln Glu Gly Leu Glu Asn Trp Met Glu Glu Leu Gln Ile Gly Ala
180 185 190
Asp Lys Lys Phe Ala Ser Arg Val Leu Lys Ala Asp Gln Pro Val Leu
195 200 205
Pro Asn Tyr Gly Ser Tyr Ala Tyr Pro Thr Asn Ile Asn Gly Thr Gln
210 215 220
Thr Lys Asp Gly Thr Thr Val Asp Lys Val Tyr Met Cys Ser Lys Gly
225 230 235 240
Ala Asn Val Gln Asn Pro Asp Val Val Leu Tyr Ser Glu Glu Val Asn
245 250 255
Leu Gln Ala Pro Asp Thr His Leu Leu Asp Gly Pro Gly Ala Asp Asn
260 265 270
Pro Lys Asp Arg Val Ala Phe Cys Ala Ala Pro Asn Arg Pro Asn Tyr
275 280 285
Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn
290 295 300
Gly Asn Gln Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val
305 310 315 320
Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Phe Leu Leu
325 330 335
Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala
340 345 350
Ile Asp Ser Tyr Asp Pro Arg Val Arg Ile Ile Glu Asn Asp Gly Val
355 360 365
Glu Asp Asp Ile Thr Ser Phe Ala Phe Asp Leu Arg Gly Ile Gly Asp
370 375 380
Leu Pro Tyr Lys Gln Val Gln Thr His Asn Gly Asn Gln Gln Ser Ala
385 390 395 400
Asn Thr Thr Asp Thr Cys Tyr Ile Gly Lys Gly Asn Met Ala Ala Met
405 410 415
Glu Ile Asn Ile Pro Ala Asn Leu Trp Leu Gly Phe Leu Tyr Ala Asn
420 425 430
Val Ala Gln Tyr Met Pro Asp Asp Phe Lys Val Asp Pro Ser Asn Ile
435 440 445
Gln Met Pro Gln Asp Lys Thr Thr Tyr Ala Tyr Met Asn Gln Arg Ile
450 455 460
Ala Pro Ala Gly Leu Ile Glu Thr Tyr Val Asn Val Gly Gly Arg Trp
465 470 475 480
Ser Val Asp Phe Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn
485 490 495
Glu Gly Leu Lys Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Phe Val
500 505 510
Asp Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu
515 520 525
Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp
530 535 540
Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp
545 550 555 560
Gly Ala Arg Leu Glu Ile His Ser Val Asn Leu Tyr Ala Ser Phe Phe
565 570 575
Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn
580 585 590
Glu Thr Asn Asp Gln Thr Phe Leu Asp Tyr Leu Ser Ser Ala Thr Met
595 600 605
Met Phe Pro Ile Pro Ala Gly Gln Thr Gln Val Pro Val Ser Ile Pro
610 615 620
Ala Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys
625 630 635 640
Gln Gln Glu Thr Pro Asn Ile Gly Ser Pro Tyr Asp Pro Tyr Phe Lys
645 650 655
Tyr Ser Gly Ser Ile Pro Phe Leu Asp Ala Thr Phe Tyr Leu Thr His
660 665 670
Thr Phe Gln Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro
675 680 685
Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg His
690 695 700
Ile Asp Ala Glu Gly Leu Cys Val Gly Gln Ser Asn Met Thr Lys Asp
705 710 715 720
Trp Phe Leu Val Gln Met Leu Ser Asn Tyr Asn Ile Gly Tyr Gln Gly
725 730 735
Phe Tyr Leu Pro Glu Asn Asn Lys Asp Arg Thr Tyr Ser Phe Val Arg
740 745 750
Asn Phe Glu Pro Leu Ala Arg Gln Val Val Asp Asp Ala Ala Ala Ala
755 760 765
Asn Tyr Arg Asp Val Pro Leu Ser Lys Arg Phe Asn Asn Ser Gly Trp
770 775 780
Arg Ser Ala Gly Pro Pro Ile Phe Ala Arg Glu Gly Ala Pro Tyr Pro
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Cys Gly Glu Ala Ala Trp Ala Ala Lys
805 810 815
Thr Gln Arg Lys Phe Leu Val Asp Arg Tyr Met Tyr Arg Ile Pro Phe
820 825 830
Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn
835 840 845
Leu Leu Tyr Ala Asn Ser Ala His Ser Leu Glu Met Thr Phe Asn Val
850 855 860
Asp Pro Met Gln Glu Ala Thr Phe Leu Tyr Ile Leu Phe Glu Val Phe
865 870 875 880
Asp Cys Val Arg Ile His Gln Pro His Arg Gly Ile Ile Glu Ala Val
885 890 895
Tyr Leu Arg Ser Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905
<210> 49
<211> 909
<212> PRT
<213> 小鼠腺病毒3（Murine adenovirus 3）
<400> 49
Met Thr Thr Pro Ser Met Gln Pro Gln Trp Ala Phe Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Gln Tyr Leu Ser Pro Gly Val Met Gln Phe Ala
20 25 30
Ala Ala Thr Glu Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Ile Val Pro Val Asp Arg Glu Asp Ser Gln Tyr Thr Tyr
65 70 75 80
Lys Thr Arg Phe Gln Leu Ser Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ala
115 120 125
Ala Pro Asn Asn Leu Met Tyr Gln Val Gly Gly Asn Asn Pro Lys Thr
130 135 140
Lys Thr Ile Ala Gln Ala Asn Ile Pro Gly Thr Gln Ile Asp Ala Asn
145 150 155 160
Gly Leu Gln Val Asn Asn Gln Asn Leu Asp Ile Gln Arg Gly Glu Pro
165 170 175
Glu Val Gln Val Gly Tyr Gln Asn Trp Met Asp Glu Leu Glu Pro Gly
180 185 190
Asn Gln Pro Lys Tyr Ala Gly Arg Val Leu Lys Thr Asn Gln Pro Val
195 200 205
Leu Pro Asn Tyr Gly Ser Tyr Ala Phe Pro Thr Asn Glu Asn Gly Thr
210 215 220
Gln Thr Lys Asn Gly Thr Gln Val Asp Lys Val Phe Met Leu Pro Lys
225 230 235 240
Val Asn Ala Gln Asn Ala Asp Val Val Leu Tyr Ser Glu Glu Val Asn
245 250 255
Leu Gln Ala Pro Asp Thr His Leu Leu Glu Gly Pro Ser Ala Ala Thr
260 265 270
Ala Thr Asn Arg Val Ala Ile Gln Ala Ala Pro Asn Arg Pro Asn Tyr
275 280 285
Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn
290 295 300
Gly Asn Gln Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val
305 310 315 320
Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Phe Leu Leu
325 330 335
Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala
340 345 350
Ile Asp Ser Tyr Asp Pro Arg Val Arg Ile Ile Glu Asn Asp Gly Val
355 360 365
Glu Asp Asp Ile Thr Ser Phe Ala Phe Asp Leu Arg Gly Val Gly Arg
370 375 380
Leu Glu Tyr Lys Gln Val Gln Thr His Gln Gly Asn Gln Gln Ala Asn
385 390 395 400
Asn Ala Asp Asp Thr Ser Tyr Ile Gly Lys Gly Asn Met Ala Ala Met
405 410 415
Glu Ile Asn Ile Pro Ala Asn Met Trp Ile Gly Phe Leu Tyr Ala Asn
420 425 430
Val Ala Gln Tyr Val Pro Asp Ala Tyr Lys Val Asp Pro Thr Asn Ile
435 440 445
Ala Met Pro Glu Asn Lys Asn Thr Tyr Ser Tyr Met Asn Gln Arg Ile
450 455 460
Ala Pro Thr Gly Leu Val Glu Thr Tyr Val Asn Met Gly Gly Arg Trp
465 470 475 480
Ser Val Asp Phe Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn
485 490 495
Asp Gly Leu Lys Tyr Arg Ser Gln Val Leu Gly Asn Gly Arg Tyr Val
500 505 510
Asp Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu
515 520 525
Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp
530 535 540
Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp
545 550 555 560
Gly Ala Ser Leu Glu Ile His Ser Val Asn Leu Tyr Ala Ser Phe Phe
565 570 575
Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn
580 585 590
Glu Thr Asn Asp Gln Thr Phe Leu Glu Tyr Leu Ser Ser Ala Thr Met
595 600 605
Met Phe Pro Ile Pro Ala Gly Gln Thr Gln Ile Pro Val Ser Ile Pro
610 615 620
Ala Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys
625 630 635 640
Gln Ser Glu Thr Pro Asn Ile Gly Ser Pro Phe Asp Pro Tyr Phe Thr
645 650 655
Tyr Ser Gly Ser Ile Pro Phe Leu Asp Ala Thr Phe Tyr Leu Thr His
660 665 670
Thr Phe Gln Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro
675 680 685
Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Asn
690 695 700
Ile Asp Gly Glu Gly Leu Cys Val Ala Gln Ser Asn Met Thr Lys Asp
705 710 715 720
Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly
725 730 735
Tyr His Leu Pro Asp Asn Asn Lys Asp Arg Thr Tyr Ser Phe Leu Arg
740 745 750
Asn Phe Glu Pro Met Thr Arg Gln Val Val Asp Arg Gln Leu Asp Gly
755 760 765
Arg Tyr Val Asp Val Met Leu Thr Lys Arg Phe Asn Asn Ser Gly Trp
770 775 780
Lys Ser Ala Ser Ala Pro Ile Phe Pro Arg Glu Gly Ala Pro Tyr Pro
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Cys Gly Glu Met Ala Trp Ala Thr Arg
805 810 815
Thr Gln Arg Lys Phe Leu Val Asp Arg Tyr Met Tyr Arg Ile Pro Phe
820 825 830
Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn
835 840 845
Leu Leu Tyr Ala Asn Ser Ala His Ser Leu Glu Met Thr Phe Glu Val
850 855 860
Asp Pro Met Thr Glu Ala Thr Tyr Leu Tyr Ile Leu Phe Glu Val Phe
865 870 875 880
Asp Cys Val Arg Ile His Gln Pro His Arg Gly Ile Ile Glu Ala Val
885 890 895
Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
900 905
<210> 50
<211> 910
<212> PRT
<213> 牛腺病毒4（Bovine adenovirus 4）
<400> 50
Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg
1 5 10 15
Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Ser
20 25 30
Phe Phe Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Thr
35 40 45
Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val
50 55 60
Pro Ile Gln Val Glu Asp Asn Glu Asn Phe Phe Lys Ala Arg Phe Thr
65 70 75 80
Leu Asn Val Gly Asp Asn Arg Ile Ala Asp Leu Gly Ser Ala Phe Phe
85 90 95
Asp Ile Glu Gly Phe Ile Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly
100 105 110
Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Leu Pro Asn Met
115 120 125
Ala Phe Lys Asn Asn Glu Glu Thr Thr Tyr Ile Ala Gln Leu Pro Gln
130 135 140
Ile Tyr Ala Ala Glu Asp Lys Gly Leu Glu Thr Ser Gln Leu Val Phe
145 150 155 160
Leu Phe Pro Ala Thr Lys Pro Asn Pro Gln Glu Gly Arg Ser Asp Glu
165 170 175
Gly Ile Ile Met Ala Leu Met Ile Leu Asp Thr Lys Lys Phe Gly Ala
180 185 190
Tyr Gly Arg Leu Ile Gly Ala Asp Ser Gln Gly Lys Ile Phe Pro Ala
195 200 205
Tyr Gly Ser Tyr Val Lys Pro Val Ser Val Glu Gly Ser Val Ser Thr
210 215 220
Ala Asp Val Gln Arg Val Tyr Leu Asn Thr Thr Asp Val Asn Asp Arg
225 230 235 240
Val Ser Gly Val Leu Ala Val Asp Thr Val Gln Arg Leu Asn Pro Asp
245 250 255
Cys His Tyr Ala Glu Tyr Thr Asn Glu Val Lys Ile Thr Ser Ser Gly
260 265 270
Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Val Gly Leu Met
275 280 285
Tyr Tyr Asn Asn Gly Ser Asn Ala Gly Thr Phe Pro Ser Gln Thr Gln
290 295 300
Gln Leu Asn Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser
305 310 315 320
Tyr Gln Tyr Leu Ile Ala Glu Ile Ser Ser Arg Tyr Lys His Phe Ala
325 330 335
Leu Trp Asn Gln Ala Val Asp Thr Tyr Asp Glu Asn Val Arg Ile Ile
340 345 350
His Asn Glu Gly Tyr Glu Glu Gly Pro Pro Val Leu Ser Phe Pro Pro
355 360 365
Phe Gly Ile Gln Asn Phe Phe Ser Asp Thr Asp Glu Gly Thr Ala Met
370 375 380
Thr Ile Gln Glu Gly Asn Gln Gln Ala Gln Lys Leu Thr Ile Gln Ser
385 390 395 400
Leu Trp Leu Trp Asn Ile Pro Thr Leu Glu Met Asn Leu Ala Ala Asn
405 410 415
Leu Gln Arg Thr Phe Leu Trp Ala Asn Val Ala Met Tyr Leu Pro Asp
420 425 430
Asn Leu Lys Arg Thr Pro Pro Asn Val Asp Leu Pro Ala Asn Lys Asn
435 440 445
Thr Tyr Gly Tyr Met Asn Gly Arg Ile Pro Tyr Pro Asn Val Ile Asp
450 455 460
Thr Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Ile Met Asp Thr
465 470 475 480
Ile Asn Pro Phe Asn His His Arg Asn Thr Gly Leu Lys Tyr Arg Ser
485 490 495
Gln Leu Leu Gly Asn Gly Arg Phe Ser Arg Phe His Ile Gln Val Pro
500 505 510
Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr
515 520 525
Asn Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Ile Phe Gln Ser
530 535 540
Ser Ile Gly Asn Asp Leu Arg Ala Asp Gly Ala Tyr Ile Asn Tyr Ser
545 550 555 560
Asn Ile Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Asp Thr Val
565 570 575
Ser Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe
580 585 590
Ala Asp Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Pro Asn
595 600 605
Thr Ser Thr Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala Phe
610 615 620
Arg Gly Trp Ser Phe Asn Arg Val Lys Ala Ser Glu Thr Pro Met Ile
625 630 635 640
Gly Ala Thr Lys Asp Pro Asn Phe Leu Tyr Ser Gly Ser Ile Pro Tyr
645 650 655
Leu Asp Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile
660 665 670
Gln Trp Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Ile
675 680 685
Pro Asn Trp Phe Glu Ile Lys Arg Asp Tyr Ser Ile Asp Ala Glu Ala
690 695 700
Thr Asn Met Ser Gln Cys Asn Ile Thr Lys Asp Trp Tyr Met Ile Gln
705 710 715 720
Met Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Leu Pro Ile
725 730 735
Ser His Lys Tyr Tyr Gly Phe Leu Glu Asn Phe Gln Pro Met Ser Arg
740 745 750
Gln Val Pro Ile Tyr Gly Gly Asp Leu Tyr Asp Leu Tyr Thr Glu Tyr
755 760 765
Ile Lys Asn Pro Asn Leu Met Gln Ile Trp Asn Asn Cys Gly Leu Gln
770 775 780
Gln Lys Thr Ser Gly Ile Pro Leu Leu Glu Asn Ser Gly His Leu Tyr
785 790 795 800
Val Ala Asn Trp Pro Tyr Pro Leu Ile Gly Lys His Ala Ile Glu Ser
805 810 815
Gln Lys Leu Gln Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro
820 825 830
Phe Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln
835 840 845
Asn Val Leu Tyr Ala Asn Ala Ser His Ser Leu Asn Met Val Phe Thr
850 855 860
Val Asp Pro Met Gln Glu Thr Thr Tyr Leu Met Leu Leu Phe Gly Val
865 870 875 880
Phe Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val
885 890 895
Ala Tyr Leu Arg Leu Pro Phe Ser Ala Gly Ser Ala Thr Thr
900 905 910
<210> 51
<211> 903
<212> PRT
<213> 白尾鹿腺病毒1（Odocoileus adenovirus 1）
<400> 51
Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg
1 5 10 15
Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Ser
20 25 30
Phe Phe Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Ser
35 40 45
Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val
50 55 60
Pro Ile Gln Thr Glu Asp Asn Glu Asn Phe Tyr Lys Ala Arg Phe Thr
65 70 75 80
Leu Asn Val Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe
85 90 95
Asp Ile Glu Gly Thr Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly
100 105 110
Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Met Pro Asn Ile
115 120 125
Thr Val Thr Lys Gly Gly Asp Thr Ile Tyr Ile Ala Gln Leu Pro Gln
130 135 140
Thr Tyr Ala Ala Asn Asp Lys Gly Val Pro Glu Ala Ile Ala Val Gln
145 150 155 160
Thr Thr Ala Ile Lys Pro Asn Pro Gln Ser Gly Gln Thr Glu Asp Phe
165 170 175
Ala Gly Val Asp Lys Val Asp Pro Thr Thr Thr Gly Gly Gln Gly Arg
180 185 190
Ile Leu Ser Ala Thr Ser Val Gly Asp Val Phe Pro Ala Tyr Gly Ser
195 200 205
Tyr Ala Pro Pro Gln Ser Val Thr Gly Asp Ile Ser Thr Glu Ala Val
210 215 220
Thr Arg Val Tyr Leu Asn Thr Thr Thr Thr Glu Asp Arg Val Ser Gly
225 230 235 240
Ile Thr Ala Val Asp Lys Ala Ile Arg Lys His Pro Asp Ala His Phe
245 250 255
Val Glu Phe Val Glu Asp Gly Lys Ala Thr Ser Ser Gly Asn Arg Pro
260 265 270
Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile Met Phe Tyr Asn
275 280 285
Asn Gly Ser Asn Ala Gly Thr Leu Ser Ser Gln Thr Gln Gln Leu Asn
290 295 300
Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr
305 310 315 320
Leu Leu Ala Asp Ile Ser Asn Arg Tyr Lys Tyr Phe Ala Leu Trp Asn
325 330 335
Gln Ala Val Asp Asn Tyr Asp Glu Tyr Val Arg Ile Leu His Asn Glu
340 345 350
Gly Tyr Glu Glu Gly Pro Pro Val Leu Ser Phe Pro Pro Asn Gly Val
355 360 365
Gln Asn Tyr Phe Thr Pro Pro Ala Lys Gly Asn Ala Met Thr Val Asp
370 375 380
Thr Gly Arg Asn Thr Ala Ala Lys Thr Asp Asn Thr Lys Ala Phe Ile
385 390 395 400
Gly Tyr Gly Asn Ile Pro Ser Leu Glu Met Asn Leu Ser Ala Asn Leu
405 410 415
Gln Arg Thr Phe Leu Trp Ala Asn Val Ala Met Tyr Leu Pro Asp Lys
420 425 430
Tyr Lys Lys Thr Pro Asn Asn Val Asp Leu Pro Ala Asn Thr Asn Ser
435 440 445
Tyr Gly Tyr Ile Asn Gly Arg Ile Pro Ile Pro Asn Val Ile Asp Thr
450 455 460
Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Asn Val
465 470 475 480
Asn Pro Phe Asn His His Arg Asn Asn Gly Leu Lys Tyr Arg Ser Gln
485 490 495
Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val Pro Gln
500 505 510
Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn
515 520 525
Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Ile Val Leu Gln Ser Ser
530 535 540
Ile Gly Asn Asp Leu Arg Ala Asp Gly Ala Ile Ile Thr Tyr Thr Ser
545 550 555 560
Ile Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Glu Thr Val Ser
565 570 575
Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ala
580 585 590
Asp Phe Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala Asn Thr
595 600 605
Asn Thr Ile Val Val Asn Ile Pro Asp Arg Ser Trp Gly Ala Phe Arg
610 615 620
Gly Trp Ser Phe Asn Arg Ile Lys Ala Thr Glu Thr Pro Met Ile Gly
625 630 635 640
Ala Thr Lys Asp Pro Asn Phe Asn Tyr Ser Gly Ser Ile Pro Tyr Leu
645 650 655
Asp Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile Gln
660 665 670
Trp Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Ile Pro
675 680 685
Asn Trp Phe Glu Ile Lys Arg Glu Pro Asn Tyr Asp Pro Glu Gly Tyr
690 695 700
Asn Ile Ser Gln Ser Thr Leu Thr Lys Asp Phe Phe Met Val Gln Met
705 710 715 720
Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Leu Pro Ser Thr
725 730 735
Tyr Lys His Tyr Gly Phe Ile Glu Asn Phe Glu Pro Met Ser Arg Gln
740 745 750
Val Pro Val Tyr Gly Asp Asp Val Phe Asp Leu Tyr Asn Ala Tyr Leu
755 760 765
Gln Asp Pro Thr Asn Met Gln Ile Trp Asn Asn Cys Gly Leu Gln Gln
770 775 780
Lys Thr Thr Asn Ile Ser Leu Leu Glu Asn Ser Gly His Leu Tyr Val
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Val Gly Arg Asp Ala Val Glu Asn Gln
805 810 815
Thr Thr Glu Lys Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro
820 825 830
Phe Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln
835 840 845
Asn Val Leu Tyr Ala Asn Ser Ser His Ser Leu Asn Met Val Phe Thr
850 855 860
Val Asp Ser Met Pro Glu Asn Thr Tyr Leu Met Leu Leu Phe Gly Val
865 870 875 880
Phe Asp Gln Val Val Val Asn Gln Pro Thr Arg Ser Gly Ile Ser Val
885 890 895
Ala Tyr Leu Arg Leu Pro Phe
900
<210> 52
<211> 902
<212> PRT
<213> 山羊腺病毒1（Goat adenovirus 1）
<400> 52
Pro Gln Arg Asp Phe Phe His Ile Ala Gly Arg Asn Ala Arg Glu Tyr
1 5 10 15
Leu Ser Glu Asn Leu Val Gln Phe Ile Ser Ala Thr Gln Ser Phe Phe
20 25 30
Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Ser Thr Gly
35 40 45
Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val Pro Ile
50 55 60
Gln Thr Glu Asp Asn Glu Asn Phe Tyr Lys Thr Arg Phe Thr Leu Asn
65 70 75 80
Val Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe Asp Ile
85 90 95
Glu Gly Val Ile Asp Arg Gly Pro Thr Phe Lys Pro Tyr Gly Gly Thr
100 105 110
Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Phe Pro Asn Ala Ala Phe
115 120 125
Met Asp Asn Asp Glu Ala Thr Thr Val Tyr Ile Ala Gln Leu Pro Asn
130 135 140
Ala Tyr Lys Ala Gln Asn Lys Gly Val Glu Glu Ala Ile Arg Val Glu
145 150 155 160
Ala Asn Thr Thr Thr Pro Asn Pro Gln Ser Gly Asp Tyr Ala Thr Tyr
165 170 175
Asp Thr Ala Lys Phe Asn Pro Glu Thr Thr Gly Ala Ser Gly Arg Leu
180 185 190
Leu Ser Ile Asn Ser Leu Gly Asp Leu Phe Pro Ala Tyr Gly Ser Tyr
195 200 205
Cys Arg Pro Gln Ser Ala Asp Gly Asn Ile Ser Thr Ala Pro Ile Thr
210 215 220
Lys Val Tyr Leu Asn Thr Thr Ala Thr Asp Asp Arg Val Ser Gly Val
225 230 235 240
Thr Ala Val Asp Thr Ala Thr Arg Leu His Pro Asp Ala His Tyr Ile
245 250 255
Glu Tyr Thr Asp Glu Ala Lys Ala Thr Ala Ile Gly Asn Arg Pro Asn
260 265 270
Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Phe Tyr Asn Asn
275 280 285
Gly Ser Asn Ala Gly Thr Phe Ser Ser Gln Thr Gln Gln Leu Asn Val
290 295 300
Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Leu
305 310 315 320
Ile Ala Asp Leu Thr Asp Arg Tyr Arg Tyr Phe Ala Leu Trp Asn Gln
325 330 335
Ala Val Asp Ser Tyr Asp Ser His Val Arg Ile Leu His Asn Glu Gly
340 345 350
Tyr Glu Glu Gly Pro Pro Ala Leu Ser Phe Pro Ser Gln Gly Ile Gln
355 360 365
Asn Tyr Phe Met Pro Thr Ala Ala Gly Asn Ala Met Thr Val Asp Thr
370 375 380
Gly Arg Asn Thr Ala Ala Lys Thr Asp Asn Thr Lys Ala Phe Ile Gly
385 390 395 400
Tyr Gly Asn Ile Pro Ser Leu Glu Met Asn Leu Thr Ala Asn Leu Gln
405 410 415
Arg Thr Phe Leu Trp Ser Asn Val Ala Met Tyr Leu Pro Asp Arg Leu
420 425 430
Lys Thr Thr Pro Pro Asn Ile Asn Leu Pro Glu Asp Thr Asn Ser Tyr
435 440 445
Gly Tyr Met Asn Gly Arg Val Pro Leu Ala Asn Ile Ile Asp Thr Trp
450 455 460
Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn
465 470 475 480
Pro Phe Asn His His Arg Asn Ser Gly Leu Lys Tyr Arg Ser Gln Leu
485 490 495
Leu Gly Asn Gly Arg Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys
500 505 510
Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr
515 520 525
Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Val Phe Gln Ser Thr Leu
530 535 540
Gly Asn Asp Leu Arg Ala Asp Gly Ala Thr Ile Thr Tyr Thr Asn Ile
545 550 555 560
Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Glu Thr Val Ser Glu
565 570 575
Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ala Asp
580 585 590
Tyr Leu Gly Ala Val Thr Asn Leu Tyr Gln Ile Pro Ala Asn Thr Asn
595 600 605
Thr Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly
610 615 620
Trp Ser Phe Asn Arg Val Lys Ala Ser Glu Thr Pro Met Ile Gly Ala
625 630 635 640
Thr Lys Asp Pro Asn Phe Thr Tyr Ser Gly Ser Ile Pro Leu Leu Asp
645 650 655
Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile Gln Trp
660 665 670
Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Val Pro Asn
675 680 685
Trp Phe Glu Ile Lys Arg Asp Pro Asn Met Asp Ala Glu Gly Tyr Thr
690 695 700
Met Ser Gln Ser Thr Ile Thr Lys Asp Phe Tyr Leu Val Gln Met Ala
705 710 715 720
Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Met Pro Ile His Ser
725 730 735
Lys Tyr Tyr Gly Phe Leu Glu Asn Phe Gln Pro Met Ser Arg Gln Val
740 745 750
Pro Ile Tyr Gly Asn Gly Thr Tyr Asp Leu Tyr Thr Ala Tyr Val Thr
755 760 765
Asn Gln Arg Thr Met Gln Ile Trp Asn Asn Ser Gly Leu Glu Ser Lys
770 775 780
Thr Ser Asn Pro Pro Ile Leu Ser Asn Thr Gly His Leu Tyr Val Ala
785 790 795 800
Asn Trp Pro Tyr Pro Leu Ile Gly Pro Asn Ala Ile Glu Asn Gln Gln
805 810 815
Thr Glu Arg Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro Phe
820 825 830
Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln Ser
835 840 845
Val Leu Tyr Thr Asn Ser Ser His Ser Leu Asn Met Val Phe Thr Val
850 855 860
Asp Ser Met Pro Glu Thr Thr Tyr Leu Met Leu Leu Phe Gly Val Phe
865 870 875 880
Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala
885 890 895
Tyr Leu Arg Leu Pro Phe
900
<210> 53
<211> 907
<212> PRT
<213> 负鼠腺病毒（Possum adenovirus）
<400> 53
Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg
1 5 10 15
Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Ser Ala Thr Gln Thr
20 25 30
Phe Phe Asn Leu Gly Asp Lys Phe Arg Asp Pro Phe Val Ala Pro Ser
35 40 45
Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val
50 55 60
Pro Ile Gln Thr Glu Asp Asn Glu Ser Phe Tyr Lys Ala Arg Phe Thr
65 70 75 80
Leu Asn Ile Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe
85 90 95
Asp Ile Glu Gly Ile Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly
100 105 110
Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Leu Pro Asn Thr
115 120 125
Ala Val Thr Glu Gly Thr Thr Leu Lys Tyr Tyr Ala Gln Leu Pro Gln
130 135 140
Leu Tyr Ser Ile Thr Asp Asn Gly Val Asn Ala Ser Thr Gln Gln Thr
145 150 155 160
Val Ser Ser Val Ile Pro Asp Pro Gln Leu Gly Gln Tyr Asn Tyr Asp
165 170 175
Glu Ile Asp Asp Ala Asp Tyr Thr Gln Lys Gly Gly Ile Gly Arg Val
180 185 190
Ile Gly Asn Asp Ser Thr Gly Asp Ala Tyr Thr Ala His Gly Leu Tyr
195 200 205
Ala Leu Pro Gln Ser Glu Gln Gly Asn Ile Ser Thr Ala Thr Ile Glu
210 215 220
Arg Val Tyr Val Asn Ser Arg Val Thr Asn Asn Ala Ile Ser Gly Val
225 230 235 240
Met Ala Val Asp Thr Ile Glu Arg Leu His Pro Asp Ser His Ile Val
245 250 255
Asp Tyr Gln Asp Asp Ala Gln Val Thr Thr Ala Gly Asp Arg Ile Asn
260 265 270
Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Thr
275 280 285
Gly Ser Asn Thr Gly Val Phe Ser Ser Gln Thr Gln Gln Leu Asn Ile
290 295 300
Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Leu
305 310 315 320
Ile Ala Asp Ile Thr Asp Arg Tyr Arg Tyr Phe Ala Leu Trp Asn Gln
325 330 335
Ala Val Asp Ser Tyr Asp Pro Phe Val Arg Val Ile Glu Asn Asp Gly
340 345 350
Tyr Glu Glu Gly Pro Pro Cys Phe Thr Phe Pro Leu Asn Gly Met Gln
355 360 365
Asn Pro Phe Ser Ser Pro Asp Ser Ser Thr Val Val Thr Asn Thr Gly
370 375 380
Ala Thr Ala Ala Gly Thr Gly Tyr Ile Ala Tyr Gly Asn Ile Pro Ser
385 390 395 400
Met Glu Met Asn Leu Thr Ala Asn Leu Gln Arg Thr Phe Leu Trp Ala
405 410 415
Asn Val Ala Met Tyr Leu Pro Asp Arg Leu Lys Ser Ser Pro Ala Asn
420 425 430
Val Asp Leu Pro Thr Asn Thr Gln Ser Tyr Gly Tyr Ile Asn Ser Arg
435 440 445
Ile Pro Leu Pro Asn Ile Ile Asp Thr Trp Thr Asn Ile Gly Ala Lys
450 455 460
Trp Ser Leu Asp Val Met Asp Asn Ile Asn Pro Phe Asn His His Arg
465 470 475 480
Asn Met Gly Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr
485 490 495
Cys Lys Phe Arg Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn
500 505 510
Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr Glu Trp Phe Phe Arg Lys
515 520 525
Asp Pro Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Tyr
530 535 540
Asp Gly Ala Ser Ile Thr Tyr Thr Ala Val Asn Leu Tyr Ile Ser Phe
545 550 555 560
Phe Pro Met Asn Tyr Asp Thr Val Ser Glu Leu Glu Leu Met Leu Arg
565 570 575
Asn Ser Thr Asn Asp Gln Asn Phe Ser Asp Tyr Leu Gly Ala Val Asn
580 585 590
Asn Leu Tyr Gln Ile Pro Ala Asn Thr Ser Thr Val Val Val Asn Ile
595 600 605
Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly Trp Ser Phe Asn Arg Val
610 615 620
Lys Ala Thr Glu Thr Pro Met Ile Gly Ser Thr Arg Asp Pro Asn Phe
625 630 635 640
Thr Tyr Ser Gly Thr Ile Pro Ile Leu Asp Gly Thr Phe Tyr Leu Ser
645 650 655
His Thr Phe Gln Lys Val Ser Ile Gln Trp Asp Ser Ser Val Pro Trp
660 665 670
Pro Gly Asp Asp Arg Met Leu Ile Pro Asn Trp Phe Glu Val Lys Arg
675 680 685
Asp Thr Asn Ser Asp Pro Glu Gly Tyr Cys Met Ser Gln Thr Ser Ile
690 695 700
Thr Lys Asp Trp Tyr Phe Val Gln Met Ala Ala Ser Tyr Asn Gln Gly
705 710 715 720
Tyr Gln Gly Tyr Arg Leu Pro Ser Thr Asn Arg Tyr Tyr Gly Phe Ile
725 730 735
Glu Asn Phe Gln Pro Met Ser Arg Gln Ile Pro Glu Tyr Ser Thr Thr
740 745 750
Asp Gly Leu Tyr Asp Leu Tyr Ser Tyr Tyr Val Ala Asn Pro Asp Ser
755 760 765
Leu Pro Ile Trp Asn Asn Cys Gly Leu Gln Pro Pro Thr Ala Pro Pro
770 775 780
Tyr Asn Pro Met Met Arg Asn Ala Gly His Leu Tyr Ala Thr Asn Trp
785 790 795 800
Pro Tyr Pro Leu Thr Gly Lys Asn Ala Val Ser Lys Gln Val Thr Glu
805 810 815
Lys Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro Phe Ser Ser
820 825 830
Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln Asn Val Leu
835 840 845
Tyr Ala Asn Ser Ser His Ser Leu Asn Met Ile Phe Ser Val Asp Ala
850 855 860
Met Asp Glu Pro Thr Tyr Leu Phe Leu Leu Phe Gly Val Phe Asp Gln
865 870 875 880
Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala Tyr Met
885 890 895
Arg Leu Pro Phe Ala Ala Gly Ser Ala Ala Ser
900 905
<210> 54
<211> 910
<212> PRT
<213> 鸭腺病毒（Duck adenovirus）
<400> 54
Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Lys
1 5 10 15
Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Asn
20 25 30
Tyr Phe Asn Leu Gly Asp Lys Phe Arg Asp Pro Tyr Val Ala Pro Thr
35 40 45
Asn Gly Val Thr Thr Asp Arg Ser Gln Lys Leu His Leu Arg Ile Val
50 55 60
Pro Ile Gln Thr Glu Asp Asn Asp Ser Phe Phe Lys Ala Arg Phe Thr
65 70 75 80
Leu Asn Val Gly Asp Asn Arg Ile Val Asp Met Gly Ser Ser Tyr Phe
85 90 95
Asp Ile Gln Gly Ile Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Arg
100 105 110
Gly Thr Ala Tyr Asn Pro Leu Ala Pro Thr Ser Gly Met Pro Asn Met
115 120 125
Ala Tyr Thr His Ser Asn Asn Thr Thr Tyr Ile Gly Gln Leu Pro Gln
130 135 140
Ile Tyr Ser Val Thr Asp Lys Gly Val Thr Glu Ala Lys Gln Gln Gln
145 150 155 160
Ile Gln Ser Thr Asp Pro Asn Pro Gln Val Gly Gln Ser Tyr Gly Ala
165 170 175
Gly Gly Pro Asp Asp Val Asp Thr Glu Lys Ser Gly Gly Lys Gly Arg
180 185 190
Leu Val Val Gly Thr Ala Gly Asp Ser Gln Val Thr Gly Phe Pro Ala
195 200 205
Tyr Gly Ser Trp Cys Pro Pro Gln Ser Val Thr Gly Asp Ile Asn Thr
210 215 220
Thr Leu Asn Pro Ser Thr Val Tyr Leu Asn Thr Thr Thr Asp Thr Asp
225 230 235 240
Arg Val Thr Gly Leu Val Ala Gly Asp Thr Val Glu Trp Asn Ala Pro
245 250 255
Asp Ala His Tyr Val Asn Tyr Val Ser Asp Met Gln Cys Ser Ala Ala
260 265 270
Gly Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile
275 280 285
Met Tyr Tyr Asn Ser Gly Ser Asn Ala Gly Ser Phe Ser Ser Gln Thr
290 295 300
Gln Gln Leu Asn Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu
305 310 315 320
Ser Phe Gln Tyr Leu Ile Ala Glu Leu Thr Asp Arg Tyr Lys His Phe
325 330 335
Ala Leu Trp Asn Gln Ala Val Asp Ser Tyr Asp Lys Phe Val Arg Val
340 345 350
Ile Glu Asn Asp Gly Tyr Glu Glu Gly Pro Pro Ser Leu Ser Phe Pro
355 360 365
Pro His Gly Phe Met Asn Phe Phe Thr Ala Pro Asp Thr Gly Thr Ala
370 375 380
Met Thr Val Ser Asp Asp Thr Ala Thr Lys Thr Ala Asn Thr Thr Ala
385 390 395 400
Ile Phe Gly Tyr Gly Asn Leu Pro Ser Met Glu Ile Asn Leu Thr Ala
405 410 415
Asn Leu Gln Arg Thr Phe Leu Trp Ser Asn Val Ala Met Tyr Leu Pro
420 425 430
Asp Tyr Leu Lys Thr Thr Pro Pro Gly Val Thr Leu Pro Ala Asn Pro
435 440 445
Asn Ser Tyr Ala Tyr Met Asn Gly Arg Leu Pro Leu Pro Asn Ile Ile
450 455 460
Asp Thr Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp
465 470 475 480
Glu Ile Asn Pro Phe Asn His His Arg Asn Leu Gly Leu Lys Tyr Arg
485 490 495
Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val
500 505 510
Pro Gln Lys Phe Phe Ala Leu Arg Asn Leu Leu Leu Leu Ser Gly Thr
515 520 525
Tyr Asn Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Ile Leu Gln
530 535 540
Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Ser Val Thr Tyr
545 550 555 560
Thr Ser Ile Asn Leu Tyr Val Ala Phe Phe Pro Leu Ala Tyr Asp Thr
565 570 575
Val Ser Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn
580 585 590
Phe Ser Asp Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala
595 600 605
Asn Ser Thr Ser Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala
610 615 620
Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Ala Arg Glu Thr Pro Ala
625 630 635 640
Ile Gly Ala Thr Lys Asp Pro Asn Phe Thr Tyr Ser Gly Ser Ile Pro
645 650 655
Leu Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Arg Val Ser
660 665 670
Ile Gln Trp Asp Ser Ser Val Pro Trp Pro Gly Asn Asp Arg Leu Leu
675 680 685
Thr Pro Asn Trp Phe Glu Ile Lys Arg Asn Val Asn Ala Asp Pro Glu
690 695 700
Gly Tyr Thr Met Ser Gln Ser Ser Ile Thr Lys Asp Trp Phe Met Val
705 710 715 720
Gln Met Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Ser Leu Pro
725 730 735
His Thr Lys Phe Tyr Asp Phe Leu Ser Asn Phe Glu Pro Met Thr Arg
740 745 750
Gln Ile Pro Asp Tyr Ser Lys Tyr Phe Asp Leu Tyr Thr Gln Tyr Leu
755 760 765
Gln Asp Pro Lys Lys Met Pro Ile Trp Asn Asn Ser Gly Val Gln Gln
770 775 780
Met Thr Asn Ser Pro Ala Leu Leu Glu Asn Thr Gly His Leu Tyr Met
785 790 795 800
Ala Asn Trp Pro Tyr Pro Leu Ile Gly Thr Ala Ala Val Glu Ser Gln
805 810 815
Ile Thr Glu Ser Lys Phe Leu Cys Asp Arg Tyr Met Trp Met Ile Pro
820 825 830
Phe Ser Ser Asn Phe Leu Asn Met Gly Thr Leu Thr Asp Leu Gly Gln
835 840 845
Asn Val Leu Tyr Ala Asn Ser Ser His Ser Leu Asn Met Val Phe Asp
850 855 860
Val Asp Pro Met Ala Glu Thr Thr Tyr Leu Leu Leu Leu Phe Gly Val
865 870 875 880
Phe Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val
885 890 895
Ala Tyr Leu Arg Leu Pro Phe Ala Ala Gly Ser Ala Ala Thr
900 905 910
<210> 55
<211> 909
<212> PRT
<213> 蛇腺病毒（Snake adenovirus）
<400> 55
Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Ser Ala Lys
1 5 10 15
Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Gln Ala Thr Gln Asn
20 25 30
Tyr Phe Asn Ile Gly Glu Lys Phe Arg Asp Pro Tyr Val Ala Pro Ser
35 40 45
Ala Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Val Val
50 55 60
Pro Met Gln Ile Glu Asp Asn Ala Asn Tyr Tyr Lys Ala Arg Phe Thr
65 70 75 80
Leu Asn Val Gly Asp Asn Arg Leu Val Asp Leu Gly Ser Ser Tyr Phe
85 90 95
Asp Ile Lys Gly Thr Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly
100 105 110
Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Pro Val Asn Ser
115 120 125
Pro Phe Ile Val Gly Asn Asp Thr His Val Val Ala Gln Leu Pro Gln
130 135 140
Thr Tyr Ala Ala Ala Asn Thr Gly Val Thr Glu Ala Ile Gln Gln Gln
145 150 155 160
Val Ser Asn Val Gln Pro Asn Pro Gln Asp Gly Leu Pro Asn Tyr Ser
165 170 175
Gly Pro Glu Val Val Asp Ala Thr Thr Lys Ala Gly Leu Gly Arg Val
180 185 190
Val Ala Glu Glu Ser Glu Gly Gln Gln Phe Pro Cys Leu Arg Ala Tyr
195 200 205
Ala Ala Pro Gln Thr Ala Ala Gly Asp Val Ser Thr Ala Pro Ile Glu
210 215 220
Lys Thr Tyr Val Asn Thr Thr Asn Val Ala Gly Arg Val Ser Gly Thr
225 230 235 240
Met Ala Thr Asp Val Ile Asp Trp Gln Asn Pro Asp Ala His Phe Val
245 250 255
Asp Tyr Val Asp Asp Gly Arg Ser Thr Ser Ala Gly Asn Arg Pro Asn
260 265 270
Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile Met Tyr Tyr Asn Ser
275 280 285
Gly Ser Asn Thr Gly Ser Leu Ser Ser Gln Thr Gln Gln Leu Asn Val
290 295 300
Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Met
305 310 315 320
Leu Ala Asp Leu Thr Ser Arg Trp His Tyr Phe Ala Leu Trp Asn Gln
325 330 335
Ala Val Asp Ser Tyr Asp Arg His Val Arg Ile Ile Glu Asn Asp Gly
340 345 350
Tyr Glu Glu Gly Pro Pro Asn Leu Ser Phe Pro Ile Gln Gly Ile Gln
355 360 365
Asn Pro Phe Ser Pro Ser Ser Val Gly Thr Glu Met Thr Val Asn Thr
370 375 380
Ala Asn Gln Thr Ala Ala Ala Thr Ala Asn Thr Val Ala His Ile Gly
385 390 395 400
Tyr Gly Asn Ile Pro Ala Val Glu Met Asn Leu Pro Ala Asn Leu Arg
405 410 415
Arg Thr Phe Leu Tyr Ala Asn Val Ala Met Tyr Leu Pro Asp Thr Tyr
420 425 430
Lys Phe Thr Pro Pro Asn Ile Asp Leu Pro Ala Asn His Leu Ser Tyr
435 440 445
Gly Tyr Met Asn Gly Arg Leu Pro Leu Pro Asn Ile Ile Asp Thr Trp
450 455 460
Thr Asp Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn
465 470 475 480
Pro Phe Asn His His Arg Asn Thr Gly Leu Lys Tyr Arg Ser Gln Leu
485 490 495
Leu Gly Asn Gly Arg His Cys Asn Phe His Ile Gln Val Pro Gln Lys
500 505 510
Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr
515 520 525
Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Val Leu Gln Ser Thr Leu
530 535 540
Gly Asn Asp Leu Arg Glu Asp Gly Ala Gln Ile Thr Tyr Asn Gln Val
545 550 555 560
Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Asp Thr Gln Ser Glu
565 570 575
Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ser Asp
580 585 590
Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala Gly Ser Asn
595 600 605
Thr Val Val Val Asn Ile Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly
610 615 620
Trp Ser Phe Thr Arg Leu Lys Val Thr Glu Thr Pro Arg Ile Gly Ala
625 630 635 640
Thr Gln Asp Pro Asn Phe Glu Tyr Ser Gly Thr Ile Pro Tyr Leu Asp
645 650 655
Gly Thr Phe Tyr Leu Ser His Thr Phe Gln Arg Cys Ser Ile Gln Trp
660 665 670
Asp Ser Ser Val Pro Trp Pro Gly Asn Asp Arg Leu Leu Val Pro Asn
675 680 685
Trp Phe Glu Ile Lys Asp Pro Pro Asn Gln Asp Pro Glu Gly Tyr Asn
690 695 700
Thr Met Gln Ser Asn Leu Thr Lys Asp Phe Phe Phe Thr Gln Met Ala
705 710 715 720
Ala Ser Tyr Asn Gln Gly Tyr Gln Gly Phe Ser Tyr Pro Ser Cys Thr
725 730 735
Lys His Tyr Gly Phe Ile Asn Asn Phe Glu Pro Met Ser Arg Gln Val
740 745 750
Pro Val Tyr Asp Ala Thr His Pro Asn Leu Met Ala Ala Tyr Leu Asn
755 760 765
Asn Pro Ala Thr Met Pro Ile Trp Asn Asn Cys Gly Phe Gln Gln Lys
770 775 780
Thr Ser Thr Asn Ala Leu Leu Glu Arg Cys Gly His Ala Tyr Val Ala
785 790 795 800
Asn Trp Pro Phe Pro Leu Thr Gly Arg Asp Ala Leu Pro Asn Gln Thr
805 810 815
Thr Glu Lys Lys Phe Leu Val Asp Asn Tyr Leu Trp Gln Ile Pro Phe
820 825 830
Ser Ser Asn Phe Leu Asn Met Gly Thr Leu Thr Asp Leu Gly Gln Asn
835 840 845
Val Met Tyr Ala Asn Ser Ser His Ser Leu Asn Met Gln Phe Thr Val
850 855 860
Asp Pro Met Asn Glu Pro Thr Tyr Leu Leu Leu Leu Phe Gly Val Phe
865 870 875 880
Asp Gln Val Val Val Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala
885 890 895
Tyr Leu Arg Leu Pro Phe Ala Ser Gly Ser Ala Ala Thr
900 905
<210> 56
<211> 906
<212> PRT
<213> 土耳其腺病毒3（Turkey adenovirus 3）
<400> 56
Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala
1 5 10 15
Gly Pro Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asn Phe Ile
20 25 30
Ser Ser Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr
35 40 45
Ile Val Ala Pro Thr Lys Gly Val Thr Thr Glu Gln Ser Gln Lys Leu
50 55 60
Gln Val Lys Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe
65 70 75 80
Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Asn Ile Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser
115 120 125
Ala Gln Phe Asn Asn Ile Lys Thr Val Gly Gly Lys Thr Tyr Leu Thr
130 135 140
Ala Gln Ala Thr Lys Phe Phe Ser Thr Ser Gly Asn Gly Cys Ala Ala
145 150 155 160
Ala Asn Thr Glu Ala Ser Ser Phe Thr Asn Leu Val Pro Ser Pro Asn
165 170 175
Thr Gly Ser Ala Glu Ser Ser Phe Asp Pro Thr Thr Glu Gly Ala Ser
180 185 190
Cys Arg Ala Ile Thr Leu Gly Ser Ser Val Thr Asp Ala Thr Cys Tyr
195 200 205
Gly Ala Tyr Thr Pro Ile Gln Asn Ala Asn Gly Ser Ile Leu Pro Pro
210 215 220
Ser Val Thr Pro Asp Lys Lys Phe Ala Asp Ala Gly Lys Ser Gly Ser
225 230 235 240
Val Thr Cys Thr Ala Ala Ile Cys Cys Asp Asn Val Thr Val Gln Tyr
245 250 255
Pro Asp Thr Arg Ile Val Ala Tyr Asp Ser Thr Asp Lys Ile Ala Thr
260 265 270
Arg Met Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile
275 280 285
Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu Ala Thr
290 295 300
Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr
305 310 315 320
Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Asn His
325 330 335
Tyr Tyr Ser Gln Trp Asn Gln Pro Val Asp Asp Tyr Asp Leu Asn Val
340 345 350
Arg Val Leu Thr Asn Ile Gly Tyr Glu Glu Gly Pro Pro Gly Tyr Cys
355 360 365
Tyr Pro Ser Thr Gly Met Gly Asn Tyr Pro Asn Thr Val Met Ser Val
370 375 380
Gly Thr Leu Val Asp Asn Asn Gly Thr Thr Ala Thr Thr Thr Ser Asn
385 390 395 400
Thr Val Ala Val Met Gly Phe Gly Ser Val Pro Thr Met Glu Ile Asn
405 410 415
Val Gln Ala Tyr Leu Gln Lys Cys Trp Met Tyr Ala Asn Ile Ala Glu
420 425 430
Tyr Leu Pro Asp Lys Tyr Lys Lys Ala Ile Gln Gly Thr Ser Glu Thr
435 440 445
Asp Pro Thr Thr Tyr Ser Tyr Met Asn Ser Arg Leu Pro Asn Val Asn
450 455 460
Met Ala Asp Leu Phe Thr His Ile Gly Gly Arg Tyr Ser Leu Asp Val
465 470 475 480
Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Arg Gly Leu Gln
485 490 495
Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Asn Val Arg Phe His Ile
500 505 510
Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro
515 520 525
Gly Thr Tyr Ser Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu Val
530 535 540
Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala Ser Ile
545 550 555 560
Gln Leu Ala Val Ile Ser Leu Tyr Ala Ser Phe Phe Pro Met Asp His
565 570 575
Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln Asn Asp
580 585 590
Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Leu Val
595 600 605
Pro Ala Asn Gln Thr Asn Val Gln Ile Glu Ile Pro Ser Arg Ala Trp
610 615 620
Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Thr Ala Glu Thr
625 630 635 640
Pro Ala Val Trp Ser Thr Tyr Asp Leu Asn Phe Lys Tyr Ser Gly Ser
645 650 655
Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Ser
660 665 670
Met Ser Ile Leu Phe Asp Ser Ala Ile Thr Trp Pro Gly Asn Asp Arg
675 680 685
Met Leu Val Pro Asn Phe Phe Glu Ile Lys Arg Glu Ile Asp Thr Glu
690 695 700
Gly Tyr Thr Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Tyr Leu Ile
705 710 715 720
Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser Phe Pro
725 730 735
Ala Asp Lys Val Tyr Arg Gln Tyr Asp Phe Met Ser Asn Phe Asp Ser
740 745 750
Met Ser Val Gln Val Pro Arg Ser Gly Leu Ala Phe Leu Phe Asn Glu
755 760 765
Asn Tyr Asn Leu Ile Val Asn Asn Ser Gly Phe Leu Pro Ser Arg Thr
770 775 780
Ala Pro Ile Ala Gly Val Asn Glu Gly His Pro Tyr Pro Ala Asn Trp
785 790 795 800
Pro Ala Pro Leu Ile Gly Asn Ser Pro Asp Ser Val Val Thr Val Arg
805 810 815
Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr Ile Pro Phe Ser Ser Asn
820 825 830
Phe Met Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr
835 840 845
Thr Glu Ser Ala His Ser Leu Gln Ile Thr Phe Asn Val Asp Pro Met
850 855 860
Pro Glu Pro Thr Tyr Ile Tyr Leu Leu Tyr Ser Val Phe Asp Cys Val
865 870 875 880
Arg Val Asn Gln Pro Asn Lys Asn Tyr Leu Ser Ala Ala Tyr Phe Arg
885 890 895
Thr Pro Phe Ala Thr Gly Thr Ala Ser Val
900 905
<210> 57
<211> 906
<212> PRT
<213> 土耳其腺病毒 A（turkey adenovirus A）
<400> 57
Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala
1 5 10 15
Gly Pro Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asn Phe Ile
20 25 30
Ser Ser Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr
35 40 45
Ile Val Ala Pro Thr Lys Gly Val Thr Thr Glu Gln Ser Gln Lys Leu
50 55 60
Gln Val Lys Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe
65 70 75 80
Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Asn Ile Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser
115 120 125
Ala Gln Phe Asn Asn Ile Lys Thr Val Gly Gly Lys Thr Tyr Leu Thr
130 135 140
Ala Gln Ala Thr Lys Phe Phe Ser Thr Ser Gly Asn Gly Cys Ala Ala
145 150 155 160
Ala Asn Thr Glu Ala Ser Ser Phe Thr Asn Leu Val Pro Ser Pro Asn
165 170 175
Thr Gly Ser Ala Glu Ser Ser Phe Asp Pro Thr Thr Glu Gly Ala Ser
180 185 190
Cys Arg Ala Ile Thr Leu Gly Ser Ser Val Thr Asp Ala Thr Cys Tyr
195 200 205
Gly Ala Tyr Thr Pro Ile Gln Asn Ala Asn Gly Ser Ile Leu Pro Pro
210 215 220
Ser Val Thr Pro Asp Lys Lys Phe Ala Asp Ala Gly Lys Ser Gly Ser
225 230 235 240
Val Thr Cys Thr Ala Ala Ile Cys Cys Asp Asn Val Thr Val Gln Tyr
245 250 255
Pro Asp Thr Arg Ile Val Ala Tyr Asp Ser Thr Asp Lys Ile Ala Thr
260 265 270
Arg Met Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile
275 280 285
Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu Ala Thr
290 295 300
Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr
305 310 315 320
Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Asn His
325 330 335
Tyr Tyr Ser Gln Trp Asn Gln Ala Val Asp Asp Tyr Asp Leu Asn Val
340 345 350
Arg Val Leu Thr Asn Ile Gly Tyr Glu Glu Gly Pro Pro Gly Tyr Cys
355 360 365
Tyr Pro Ser Thr Gly Met Gly Asn Tyr Pro Asn Thr Val Met Ser Val
370 375 380
Gly Thr Leu Val Asp Asn Asn Gly Thr Thr Ala Thr Thr Thr Ser Asn
385 390 395 400
Thr Val Ala Val Met Gly Phe Gly Ser Val Pro Thr Met Glu Ile Asn
405 410 415
Val Gln Ala Tyr Leu Gln Lys Cys Trp Met Tyr Ala Asn Ile Ala Glu
420 425 430
Tyr Leu Pro Asp Lys Tyr Lys Lys Ala Ile Gln Gly Thr Ser Glu Thr
435 440 445
Asp Pro Thr Thr Tyr Ser Tyr Met Asn Ser Arg Leu Pro Asn Val Asn
450 455 460
Met Ala Asp Leu Phe Thr His Ile Gly Gly Arg Tyr Ser Leu Asp Val
465 470 475 480
Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Arg Gly Leu Gln
485 490 495
Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Asn Val Arg Phe His Ile
500 505 510
Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro
515 520 525
Gly Thr Tyr Ser Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu Val
530 535 540
Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala Ser Ile
545 550 555 560
Gln Phe Ser Ser Ile Ser Leu Tyr Ala Ser Phe Phe Pro Met Asp His
565 570 575
Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln Asn Asp
580 585 590
Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Leu Val
595 600 605
Pro Ala Asn Gln Thr Asn Val Gln Ile Glu Ile Pro Ser Arg Ala Trp
610 615 620
Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Thr Ala Glu Thr
625 630 635 640
Pro Ala Val Trp Ser Thr Tyr Asp Leu Asn Phe Lys Tyr Ser Gly Ser
645 650 655
Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Ser
660 665 670
Met Ser Ile Leu Phe Asp Ser Ala Ile Thr Trp Pro Gly Asn Asp Arg
675 680 685
Met Leu Val Pro Asn Phe Phe Glu Ile Lys Arg Glu Ile Asp Thr Glu
690 695 700
Gly Tyr Thr Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Tyr Leu Ile
705 710 715 720
Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser Phe Pro
725 730 735
Ala Asp Lys Val Tyr Arg Gln Tyr Asp Phe Met Ser Asn Phe Asp Ser
740 745 750
Met Ser Val Gln Val Pro Arg Ser Gly Leu Ala Phe Leu Phe Asn Glu
755 760 765
Asn Tyr Asn Leu Ile Val Asn Asn Ser Gly Phe Leu Pro Ser Arg Thr
770 775 780
Ala Pro Ile Ala Gly Val Asn Glu Gly His Pro Tyr Pro Ala Asn Trp
785 790 795 800
Pro Ala Pro Leu Ile Gly Asn Ser Pro Asp Ser Val Val Thr Val Arg
805 810 815
Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr Ile Pro Phe Ser Ser Asn
820 825 830
Phe Met Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr
835 840 845
Thr Glu Ser Ala His Ser Leu Gln Ile Thr Phe Asn Val Asp Pro Met
850 855 860
Pro Glu Pro Thr Tyr Ile Tyr Leu Leu Tyr Ser Val Phe Asp Cys Val
865 870 875 880
Arg Val Asn Gln Pro Asn Lys Asn Tyr Leu Ser Ala Ala Tyr Phe Arg
885 890 895
Thr Pro Phe Ala Thr Gly Thr Ala Ser Val
900 905
<210> 58
<211> 912
<212> PRT
<213> 猛禽腺病毒A（Raptor adenovirus A）
<400> 58
Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asp Phe Ile
20 25 30
Thr Asn Thr Glu Thr Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr
35 40 45
Ile Val Ala Pro Thr Lys Asn Val Thr Thr Glu Gln Ser Gln Arg Leu
50 55 60
Gln Val Arg Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe
65 70 75 80
Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Cys Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser
115 120 125
Ala Gln Tyr Asn Asn Ile Arg Lys Val Gly Asn Thr Thr Val Leu Thr
130 135 140
Ala Gln Ala Ser Asn Leu Tyr Thr Ile Ala Ser Ser Gln Asn Gly Ala
145 150 155 160
Ala Ala Ala Asn Thr Val Ala Asn Asp Phe Ser Asn Ile Val Pro Ser
165 170 175
Pro Asn Thr Gly Ile Thr Glu Ser Thr Val Asp Asn Thr Thr Gln Gly
180 185 190
Gly Ser Gly Arg Ala Val Ile Leu Pro Asp Glu Phe Pro Glu Thr Thr
195 200 205
Ala Tyr Gly Ala Tyr Ala Ser Pro Thr Ser Val Asp Gly Gly Gln Leu
210 215 220
Pro Ala Ser Lys Ala Ile Gln Lys Lys Tyr Ala Asp Ala Gly Lys Ser
225 230 235 240
Gly Asn Val Lys Val Thr Ser Ala Phe Ala Gly Glu Glu Leu Asn Val
245 250 255
Ile Tyr Pro Asp Thr Arg Ile Val Ala Tyr Asp Asn Thr Ala Lys Leu
260 265 270
Ala Thr Arg Met Gly Ser Arg Pro Asn Phe Ile Gly Phe Arg Asp Asn
275 280 285
Phe Ile Gly Ile Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu
290 295 300
Ala Thr Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg
305 310 315 320
Asn Thr Glu Leu Ser Tyr Gln Trp Leu Leu Asn Asp Leu Met Ser Arg
325 330 335
Gln His Tyr Phe Thr Gln Trp Asn Gln Ala Val Asp Asp Tyr Asp Leu
340 345 350
Asn Val Arg Val Leu Cys Asn Thr Gly Tyr Glu Glu Gly Pro Pro Gly
355 360 365
Gln Val Tyr Pro Ile Thr Gly Met Gly Asn Tyr Pro Ala Asn Val Leu
370 375 380
Lys Val Gly Lys Met Val Thr Asn Thr Gly Ser Asp Ala Asn Thr Val
385 390 395 400
Ser Asn Thr Leu Ser Ile Val Gly Phe Gly Ser Val Pro Ala Trp Glu
405 410 415
Met Asn Met Gln Ala Gln Leu Gln Arg Ser Trp Leu Tyr Ser Asn Ile
420 425 430
Ala Glu Tyr Leu Pro Asp Thr Leu Lys Tyr Ser Ala Pro Leu Ala Leu
435 440 445
Asp Glu Asp Pro Thr Thr Tyr Asn Tyr Met Asn Thr Arg Leu Pro Asn
450 455 460
Val Asn Val Val Asp Leu Phe Thr Asn Ile Gly Gly Arg Tyr Ser Leu
465 470 475 480
Asp Ile Met Asp Asn Gln Asn Pro Phe Asn His His Lys Asn Arg Gly
485 490 495
Leu Gln Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Val Cys Asp Phe
500 505 510
His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu
515 520 525
Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn
530 535 540
Leu Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala
545 550 555 560
Val Ile Glu Tyr Thr Asn Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met
565 570 575
Asp His Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln
580 585 590
Asn Asp Gln Thr Phe Met Asp Tyr Leu Gly Ala Lys Asn Asn Leu Tyr
595 600 605
Val Val Pro Pro Asp Val Ser Asn Leu Gln Ile Glu Ile Pro Ser Arg
610 615 620
Ser Trp Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Met Lys Ala Ser
625 630 635 640
Glu Thr Pro Ala Val Trp Ser Thr Tyr Asp Val Asn Phe His Tyr Ser
645 650 655
Gly Ser Ile Pro Tyr Leu Asp Ser Thr Phe Tyr Leu Ser His Thr Phe
660 665 670
Asn Ser Leu Ala Ile Thr Phe Asp Ser Ala Val Pro Trp Pro Gly Asn
675 680 685
Asp Arg Leu Leu Leu Pro Asn Phe Phe Glu Ile Lys Arg Asn Tyr Asp
690 695 700
Ser Glu Gly Tyr Cys Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Trp
705 710 715 720
Leu Ile Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser
725 730 735
Tyr Pro Ala Asp Lys Thr Tyr Arg Gln Tyr Asp Phe Ile Ser Asn Phe
740 745 750
Asp Pro Met Ser Ile Gln Val Pro Ala Asn Ser Ile Asn Leu Ile Ser
755 760 765
Pro Ser Val Gln Ser Ser Ser Lys Asn Ala Ile Trp Asn Asn Ser Gly
770 775 780
Tyr Val Ala Pro Arg Asp Lys Thr Leu Ala Thr Pro Asn Gln Gly His
785 790 795 800
Pro Tyr Pro Ala Asn Trp Pro Ala Pro Leu Ile Gly Asp Tyr Asn Val
805 810 815
Ser Met Arg Thr Val Arg Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr
820 825 830
Ile Pro Phe Ser Ser Asn Phe Met Asn Met Gly Glu Leu Thr Asp Leu
835 840 845
Gly Gln Ser Leu Leu Tyr Thr Glu Ser Ala His Ser Leu Gln Ile Ser
850 855 860
Phe Asn Leu Asp Pro Met Pro Glu Thr Thr Tyr Val Tyr Met Leu Tyr
865 870 875 880
Ser Val Phe Asp Cys Val Arg Val Asn Gln Pro Asn Lys Asn Tyr Val
885 890 895
Ser Ala Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Thr Ala Ser Ala
900 905 910
<210> 59
<211> 901
<212> PRT
<213> 大山雀腺病毒1（Great tit adenovirus 1）
<400> 59
Met Asp Ile Ser Asn Gly Thr Pro Lys Leu Asp Ile Phe His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asp Phe Ile
20 25 30
Thr Asn Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr
35 40 45
Ile Val Ala Pro Thr Lys Asn Val Thr Thr Glu Gln Ser Gln Arg Leu
50 55 60
Gln Val Arg Ile Val Pro Thr Leu Thr Gln Asp Leu Glu His Ser Tyr
65 70 75 80
Thr Ala Arg Phe Thr Val Ala Val Gly Asp Gly Arg Val Leu Asp Met
85 90 95
Gly Ser Pro Tyr Phe Asp Ile Arg Gly Thr Ile Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Gln Gly Thr Ala Phe Asn Pro Leu Ala Pro Arg Ser
115 120 125
Ala Met Phe Asn Asn Ile Arg Lys Ile Asp Asn Thr Thr Ile Leu Thr
130 135 140
Ala Gln Ala Ser His Tyr Tyr Asp Val Ser Ser Gly Asn Gly Cys Ala
145 150 155 160
Glu Ala Gln Asn Glu Ala Asn Arg Phe Ser Gly Ile Val Pro Ser Pro
165 170 175
Asn Val Gly Leu Ser Glu Ser Thr Met Asp His Arg Ser Ser Gly Ala
180 185 190
Ser Gly Arg Val Val Leu Leu Ala Asp Asn Lys Glu Ala Thr Ala Tyr
195 200 205
Gly Ala Phe Ala Pro Ala Lys Gln Leu Asn Gly Ser Gln Leu Gly Val
210 215 220
Gly Thr Ala Ile Gln Pro Arg Phe Thr Asn Ala Gly Lys Glu Gly Asn
225 230 235 240
Leu Thr Cys Thr Gly Ala Phe Ala Gly Glu Glu Ile Glu Val Tyr Tyr
245 250 255
Pro Asp Thr Arg Ile Val Met Trp Asp Asp Asp Thr Lys Ile Ala Val
260 265 270
Arg Met Gly Lys Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile
275 280 285
Gly Leu Met Tyr Tyr Asp Asn Gly Ala Leu Ser Gly Ser Leu Ala Thr
290 295 300
Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr
305 310 315 320
Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Gln His
325 330 335
Tyr Tyr Thr Gln Trp Asn Gln Ala Val Asp Asp Tyr Glu Leu Gly Ile
340 345 350
Arg Val Leu Thr Asn Thr Gly Tyr Glu Glu Gly Pro Pro Ser Phe Ser
355 360 365
Phe Pro Ser Leu Gly Met Gly Asn Tyr Pro Tyr Leu Gly Leu Asp Gly
370 375 380
Gly Ile Met Val Glu Asn Asn Gly Ala Ala Ala Thr Asp Ile Ala Asn
385 390 395 400
Thr Ala Ala Gly Ile Gly Phe Gly Ser Val Pro Ser Met Glu Leu Asn
405 410 415
Leu His Ala Tyr Ile Gln Arg Ser Trp Met Tyr Ser Asn Ile Ala Glu
420 425 430
Tyr Leu Pro Asp Asn Leu Lys Tyr Asp Val Pro Gly Leu Pro Pro Val
435 440 445
Pro Ala Ala Asn Thr Tyr Asn Tyr Leu Asn Ala Arg Leu Pro His Val
450 455 460
Asn Val Val Asp Leu Phe Thr His Leu Gly Gly Arg Tyr Ser Leu Asp
465 470 475 480
Val Met Asp Asn Gln Asn Pro Phe Asn His His Lys Asn Arg Gly Leu
485 490 495
Gln Tyr Arg Ser Gln Ile Leu Gly Asn Ala Arg Lys Val Asp Phe His
500 505 510
Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Thr
515 520 525
Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu
530 535 540
Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Ser
545 550 555 560
Val Gln Phe Thr Ser Ile Thr Leu Phe Ala Ser Phe Phe Pro Met Asp
565 570 575
His Ala Thr Ala Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Thr Asn
580 585 590
Asp Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Val
595 600 605
Val Pro Pro Asn Thr Ser Asn Leu Gln Val Glu Ile Pro Ser Arg Ala
610 615 620
Trp Thr Gly Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Ala Gln Glu
625 630 635 640
Thr Pro Ala Ile Trp Ser Thr Tyr Asp Val Asn Phe Lys Tyr Ser Gly
645 650 655
Ser Ile Pro Phe Leu Asp Ser Thr Phe Tyr Leu Gly His Thr Phe Asn
660 665 670
Ser Val Ser Ile Thr Phe Asp Ser Ala Ile Pro Trp Pro Gly Asn Asp
675 680 685
Arg Leu Leu Leu Pro Asn Tyr Phe Gln Ile Gln Arg Arg Gly Pro Asp
690 695 700
Ala Glu Gly Tyr Cys Thr Cys Gln Ser Thr Met Thr Lys Asp Trp Tyr
705 710 715 720
Leu Ile Gln Met Leu Gly Asn Tyr Asn Gln Gly Phe His Gly Tyr Ser
725 730 735
Phe Pro Val Asp Lys Thr Phe Arg Gln Tyr Asp Phe Ile Ala Asn Phe
740 745 750
Asp Pro Met Cys Leu Gln Leu Pro Gln Asn Ile Leu Asp Leu Ser Pro
755 760 765
Ile Ile Val Ser Asn Pro Asp Val Val Arg Asn Asn Ser Gly Tyr Val
770 775 780
Ala Pro Arg Ser Ser Ser Ile Ala Leu Arg Asn Glu Gly His Pro Tyr
785 790 795 800
Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asp Val Gly Gly Thr
805 810 815
Ser Val Gly Thr Arg Thr Val Arg Lys Phe Leu Cys Asp Lys Tyr Leu
820 825 830
Trp Asn Ile Pro Phe Ser Ser Asn Phe Met Asn Met Gly Glu Leu Thr
835 840 845
Asp Leu Gly Gln Ser Leu Leu Tyr Thr Glu Ser Ala His Ser Leu Gln
850 855 860
Leu Ser Phe Glu Leu Glu Pro Met Ser Asp Val Thr Tyr Val Tyr Leu
865 870 875 880
Leu Phe Asn Val Phe Asp Cys Val Arg Val Asn Gln Pro Asn Lys Asn
885 890 895
Tyr Val Ser Ala Ala
900
<210> 60
<211> 920
<212> PRT
<213> 蛙腺病毒1（frog adenovirus 1）
<400> 60
Met Asp Ile Tyr Asn Gly Thr Pro Lys Leu Asp Ile Phe His Ile Ala
1 5 10 15
Gly Arg Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Ile Asp Phe Met
20 25 30
Ser Ser Thr Glu Ser Tyr Phe Ser Ile Asn Lys Lys Phe Arg Glu Thr
35 40 45
Ile Val Ala Pro Thr Lys Gly Val Thr Ser Glu Gln Ser Gln Arg Leu
50 55 60
Gln Val Arg Ile Ile Pro Val Gln Thr Gln Asp Ala Glu Gln Thr Tyr
65 70 75 80
Thr Ala Arg Phe Thr Ile Ala Val Gly Glu Gly Arg Val Leu Asp Met
85 90 95
Gly Ser Thr Tyr Phe Asp Ile Arg Gly Ile Val Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser
115 120 125
Ala Val Phe Asn Asn Val Lys Thr Val Ser Ile Gly Gly Thr Asn Thr
130 135 140
Ser Val Leu Thr Ala Gln Ala Pro His Leu Tyr Ser Ile Asn Thr Gly
145 150 155 160
Asp Asn Gly Cys Thr Ala Ala Thr Thr Thr Ala Ala Thr Phe Ser Gly
165 170 175
Thr Val Pro Asn Pro Gly Gly Gly Asp Ile Glu Gln Thr Phe Ser Ser
180 185 190
Asn Glu Gly Gly Ala Gly Arg Val Val Asn Ala Gln Gln Asp Thr Gly
195 200 205
Val Tyr Gly Ala Tyr Ala Gln Pro Val Asn Glu Ala Gly Asn Gln Asn
210 215 220
Thr Ala Ala Val Thr Ser Lys Phe Thr Asn Ala Gly Lys Gly Gly Asn
225 230 235 240
Val Thr Cys Thr Ser Ala Phe Ala Val Glu Thr Val Gly Leu Thr Tyr
245 250 255
Pro Asp Thr Arg Val Val Ala Tyr Asp Asp Asp Thr Gly Asp Val Thr
260 265 270
Arg Leu Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Val
275 280 285
Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Thr Leu Ala Thr
290 295 300
Glu Thr Gly Asp Ile Asn Ile Val Glu Pro Leu Gln Asp Arg Asn Thr
305 310 315 320
Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg His His
325 330 335
Tyr Phe Ala Met Trp Asn Gln Ala Val Asp Asp Tyr Glu Leu Gly Val
340 345 350
Arg Val Leu Ser Asn His Gly Tyr Glu Glu Ala Met Pro Ala Leu Ser
355 360 365
Phe Asn Thr Thr Gly Met Gly Asn Tyr Gly Gly Ala Ala Leu Leu Ser
370 375 380
Gly Gln Gln Val Thr Ile Asn Ser Asn Ala Ala Thr Ala Val Ala Asn
385 390 395 400
Ser Lys Ala Leu Ile Gly Phe Gly Ala Val Pro Ser Met Glu Met Asn
405 410 415
Leu Gly Ala Gln Leu Ala Arg Ser Trp Leu Phe Ala Asn Val Ala Glu
420 425 430
Tyr Met Pro Asp Asp Leu Lys Val Ser Val Asn Val Pro Gln Arg Tyr
435 440 445
Pro Gln Pro Gly Thr Asn Thr Ser Ser Tyr Asn Tyr Lys Asn Leu Arg
450 455 460
Leu Pro Asn Val Asn Leu Ile Asp Leu Phe Thr Gln Ile Gly Gly Arg
465 470 475 480
Tyr Ser Leu Ser Phe Met Asp Asn Val Asn Pro Phe Asn His His Lys
485 490 495
Asn Arg Gly Leu Lys Tyr Arg Ser Glu Leu Leu Gly Asn Gly Arg Ile
500 505 510
Ala Lys Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Lys
515 520 525
Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys
530 535 540
Asp Pro Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Leu
545 550 555 560
Asp Gly Ala Thr Ile Gln Tyr Thr Ser Ile Asn Leu Phe Ala Ser Phe
565 570 575
Phe Pro Met Asp His Ala Thr Cys Asn Asp Leu Ile Leu Met Leu Arg
580 585 590
Asn Glu Thr Asn Asp Gln Ser Phe Met Asp Tyr Met Gly Gly Lys Asn
595 600 605
Asn Leu Tyr Val Val Pro Pro Asn Thr Glu Asn Leu Gln Ile Glu Ile
610 615 620
Pro Ser Arg Thr Trp Glu Ala Phe Arg Gly Trp Ser Phe Asn Arg Leu
625 630 635 640
Lys Thr Ala Glu Thr Pro Ser Val Trp Ser Thr Tyr Asp Val Asn Phe
645 650 655
Lys Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Ser Phe Tyr Leu Ser
660 665 670
His Thr Phe Lys Asn Ile Ala Ile Asn Phe Asp Ser Ala Val Pro Trp
675 680 685
Pro Gly Asn Asp Arg Met Leu Val Pro Asn Tyr Phe Glu Ile Lys Arg
690 695 700
Thr Gly Pro Asp Ser Glu Gly Tyr Cys Val Ala Gln Ser Asn Met Thr
705 710 715 720
Lys Asp Trp Phe Leu Val Gln Met Ser Gly Asn Tyr Asn Gln Gly Tyr
725 730 735
His Gly Tyr Ser Phe Pro Val Asp Lys Thr Tyr Arg Gln Tyr Asp Phe
740 745 750
Ile Ser Asn Phe Asp Pro Met Ser Ile Gln Met Pro Asp Tyr Thr Gln
755 760 765
Gln Asn Ile Tyr Asp Leu Leu Thr Ala Ala Thr Ser Ala Thr Gly Arg
770 775 780
Asp Ile Ile Arg Asn Asn Thr Gly Phe Thr Ala Asn Arg Leu Asn Pro
785 790 795 800
Ser Val Ser Asp His Thr Gly His Pro Tyr Pro Cys Asn Trp Pro Tyr
805 810 815
Pro Leu Ile Gly Ser Gln Ala Val Ala Ser Val Thr His Arg Lys Phe
820 825 830
Leu Cys Asp Lys Tyr Leu Trp Asn Ile Pro Phe Ser Ser Asn Phe Met
835 840 845
Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr Thr Asn
850 855 860
Ser Ser His Ser Ile Gln Ile Ser Ile Glu Leu Glu Pro Met Asn Glu
865 870 875 880
Thr Thr Tyr Val Tyr Met Ile Phe Gly Val Phe Asp Ala Val Arg Val
885 890 895
Asn Gln Pro Asn Lys Asn Ser Val Ser Ala Ala Tyr Phe Arg Thr Pro
900 905 910
Phe Ala Thr Gly Thr Ala Ser Ala
915 920
<210> 61
<211> 944
<212> PRT
<213> 高首鲟腺病毒（White sturgeon adenovirus）
<400> 61
Met Asp Thr Leu Tyr Lys Met Thr Pro Val Gln Thr Met His Ile Met
1 5 10 15
Gly Pro Asp Ala Ser Gln Tyr Leu Ser Glu Gly Ser Lys Ser Leu Pro
20 25 30
Pro Tyr Gly Gln Lys Ile Phe Lys Leu Asn Asn Lys Phe Arg Asp Thr
35 40 45
Val Ala Ala Pro Leu His Val Thr Thr Ser Glu Ser Gln Arg Met Ala
50 55 60
Tyr Met Tyr Ser Pro Gln Thr Ile Asp Asn Ala Asn Gln Ala Tyr Trp
65 70 75 80
Ser Gly Arg Phe Gln Leu Pro Val Pro Asn Asn Arg Ile Leu Asp Met
85 90 95
Gly Gly Ser Phe Phe Asp Ile Glu Gly Thr Leu Asp Arg Gly Lys Ser
100 105 110
Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Cys Leu Ala Pro His Ser
115 120 125
Ser Thr Phe Asn Phe Ile Arg Gly Leu Val Leu Asn Ala Gln Ser Gly
130 135 140
Asn Ala Val Ala Gly Leu Asp Ala Pro Leu Thr Ala Ser Thr Asp Val
145 150 155 160
Gln Ala Ala Gln Thr Ala Met Leu Thr Phe Ser Gly Ser Asn Pro Ser
165 170 175
Pro Asn Val Gly Leu Asn Tyr Thr Pro Asp Pro Ser Gly Leu Leu Phe
180 185 190
Gly Gly Arg Ala Val Val Leu Ser Glu Asp Ala Thr Pro Thr Thr Pro
195 200 205
Ser Tyr Lys Asp Ala Asn Ala Tyr Gly Ala Tyr Met Thr Pro Leu Asp
210 215 220
Ile Tyr Gly Ala Val Asp Asp Asn Val Gly Lys Leu Tyr Thr Cys Arg
225 230 235 240
Ala Gly Val Thr Asp Ala Asn Asn Thr Ala Arg Lys Ile Thr Asp Leu
245 250 255
Trp Ala Cys Asp Asn Thr Gln Val Ser Phe Pro Asp Thr Arg Val Val
260 265 270
Ser Tyr Asn Pro Asp Leu Met Thr Thr Thr Arg Val Gly Asn Arg Met
275 280 285
Asn Cys Val Ala Phe Arg Asp Asn Phe Ile Asn Met Leu Tyr Tyr Asp
290 295 300
Ser Thr Asn Thr Gly Val Leu Glu Ser Phe Ala Asn Gly Asn Asn Val
305 310 315 320
Cys Leu Asp Ser Ala Gln Asp Arg Ser Thr Glu Leu Gly Tyr Gln Tyr
325 330 335
Trp Leu Ala Gly Val Ser Ser Arg Tyr His Asn Tyr Asp Ile Phe Asn
340 345 350
Gln Ser Ile Asp Ser Tyr Asp Lys Arg Val Arg Phe Phe Thr Asn Arg
355 360 365
Gly Phe Asp Asp Gly Leu Pro Ser Tyr Ala Tyr Asn Thr Asn Ala Arg
370 375 380
Ser Gly Leu Thr Thr Gly Lys Met Val Asp Asn Thr Gly Ala Glu Leu
385 390 395 400
Val Ile Gln Asn Asn Ala Ser Ile Glu Thr Gln Ala Leu Val Gly Asn
405 410 415
Gly Lys Met Thr His Tyr Glu Ile Asn Leu Lys Ser Gln Lys Phe Lys
420 425 430
Asn Trp Ile Tyr Thr Asn Ile Ser Glu Tyr Leu Pro Asp Lys Tyr Lys
435 440 445
Thr Pro Ala Ser Val Thr Gly Thr Asn Tyr Pro Pro Phe Pro Thr Pro
450 455 460
Gly Thr Asp Pro Thr Thr Tyr Ala Tyr Lys Asn Leu Met Ile Pro Ser
465 470 475 480
Gln Asn Ile Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Tyr Ser Ile
485 490 495
Pro Gln Thr Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly
500 505 510
Leu Asn His Arg Ser Met Leu Leu Gly Asn Ser Arg Ile Thr Asn Phe
515 520 525
Ala Ile Gln Val Pro Asn Lys Phe Phe Ala Ile Lys Asn Leu Ala Leu
530 535 540
Leu Pro Gly Asn Tyr Asn Tyr Glu Trp Lys Phe Arg Lys Asp Val Asn
545 550 555 560
Met Val Leu Gln Ser Thr Leu Gly Ile Asp Leu Arg Ala Asp Glu Ala
565 570 575
Thr Ile Asp Tyr Ser Arg Val Lys Leu Tyr Cys Pro Phe Phe Pro Phe
580 585 590
Asn His Lys Asp Val Ala Glu Leu Asp Met Leu Leu Arg Gln Gln Asn
595 600 605
Asn Ser Gln Thr Phe Tyr Asp Pro Leu Asn Ser Arg Ser Gln Phe Ile
610 615 620
Glu Val Pro Ala Gly Ile Thr Asn Ile Ser Val Thr Val Pro Ala Gln
625 630 635 640
Ser Trp Ser Cys Phe Arg Gly Trp Lys Phe Asn Arg Leu Lys Ala Ser
645 650 655
Glu Arg Cys Asn Lys Asn Ala Val Tyr Glu Thr Gly Leu Lys Tyr Ser
660 665 670
Gly Thr Tyr Pro His Ile Asp Gly Thr Tyr Tyr Leu Gly His Thr Phe
675 680 685
Arg Ala Leu Glu Ile Lys Trp Asp Thr Ser Val Pro Trp Pro Gly Asn
690 695 700
Asp Arg Leu Phe Ser Pro Asn Tyr Phe Glu Met Lys Arg Thr Leu Asp
705 710 715 720
Asn Gly Phe Ala Asp Asn Tyr Cys Ile Ala Gln Cys Asp Met Thr Lys
725 730 735
Asp Trp Trp Leu Val Gln Asn Ser Ala Asn Tyr Asn Gln Gly Tyr Gln
740 745 750
Gly Tyr Gln Tyr Pro Ser Ser Lys Thr Tyr Phe Glu Tyr Asp Phe Met
755 760 765
Arg Asn Phe Val Pro Met Ser Arg Gln Val Pro Asn Met Glu Pro Leu
770 775 780
Lys Met Asp Leu Gln Phe Gly Thr Ala Thr Trp Ala Leu Pro Tyr Pro
785 790 795 800
Gly Lys Ser Thr Phe Asn Asn Thr Ile Arg Asn Asn Ser Gly Phe Ile
805 810 815
Ala Pro Arg Asp Ala Met Pro Gln Thr Asp Ala Arg Gly Ala Pro Tyr
820 825 830
Pro Ala Asn Trp Pro Tyr Pro Leu Ile Ser Glu Lys Ala Leu Pro Asp
835 840 845
Gly Gln Ile Met Thr Glu Lys Lys Phe Leu Cys Asp Lys Tyr Leu Trp
850 855 860
Asn Val Pro Phe Ser Ser Asn Phe Phe Asn Met Gly Glu Leu Thr Asp
865 870 875 880
Glu Gly Gln Ser Asn Met Val Val Gln Ser Ala Ser Asn Leu Gln Met
885 890 895
Asn Phe Asn Leu Asp Pro Met Asp Glu Pro Thr Leu Ile His Ile Leu
900 905 910
Tyr Gly Val Phe Asp Cys Val Gln Val Ser Gln Pro Ala Arg Asn Val
915 920 925
Ile Ser Ala Leu Tyr Phe Arg Thr Pro Phe Asn Ile Gly Ala Asn Ala
930 935 940
<210> 62
<211> 942
<212> PRT
<213> 禽腺病毒1（fowl adenovirus 1）
<400> 62
Met Thr Ala Leu Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln
1 5 10 15
Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp
20 25 30
Leu Gln Gln Phe Ile Ser Ala Thr Gly Ser Tyr Phe Asp Leu Lys Asn
35 40 45
Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu
50 55 60
Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Ile Gln Thr Asp Asp
65 70 75 80
Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Val Asn Val Gly Asp Ser
85 90 95
Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu
100 105 110
Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro
115 120 125
Leu Ala Pro Arg Glu Ala Ile Phe Asn Thr Trp Val Glu Ser Thr Gly
130 135 140
Pro Gln Thr Asn Val Val Gly Gln Met Thr Asn Val Tyr Thr Asn Gln
145 150 155 160
Thr Arg Asn Asp Lys Thr Ala Thr Leu Gln Gln Val Asn Ser Ile Ser
165 170 175
Gly Val Val Pro Asn Val Asn Leu Gly Pro Gly Leu Ser Gln Leu Ala
180 185 190
Ser Arg Ala Asp Val Asp Asn Ile Gly Val Val Gly Arg Phe Ala Lys
195 200 205
Val Asp Ser Ala Gly Val Lys Gln Ala Tyr Gly Ala Tyr Val Lys Pro
210 215 220
Val Lys Asp Asp Gly Ser Gln Ser Leu Asn Gln Thr Ala Tyr Trp Leu
225 230 235 240
Met Asp Asn Gly Gly Thr Asn Tyr Leu Gly Ala Leu Ala Val Glu Asp
245 250 255
Tyr Thr Gln Thr Leu Ser Tyr Pro Asp Thr Val Leu Val Thr Pro Pro
260 265 270
Thr Ala Tyr Gln Gln Val Asn Ser Gly Thr Met Arg Ala Cys Arg Pro
275 280 285
Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp
290 295 300
Ser Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met Asn
305 310 315 320
Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr
325 330 335
Met Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn
340 345 350
Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp
355 360 365
Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Leu Pro Asp Gly His
370 375 380
Gly Ala Gly Glu Asp Asn Gly Pro Asp Leu Ser Asn Val Lys Ile Tyr
385 390 395 400
Thr Asn Gly Gln Gln Asp Lys Gly Asn Val Val Ala Gly Thr Val Ser
405 410 415
Thr Gln Leu Asn Phe Gly Thr Ile Pro Ser Tyr Glu Ile Asp Ile Ala
420 425 430
Ala Ala Thr Arg Arg Asn Phe Ile Met Ser Asn Ile Ala Asp Tyr Leu
435 440 445
Pro Asp Lys Tyr Lys Phe Ser Ile Arg Gly Phe Asp Pro Val Thr Asp
450 455 460
Asn Ile Asp Pro Thr Thr Tyr Phe Tyr Met Asn Arg Arg Val Pro Leu
465 470 475 480
Thr Asn Val Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Trp Ser Val
485 490 495
Asp Gln Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly
500 505 510
Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Arg Phe
515 520 525
His Ile Gln Val Pro Gln Lys Tyr Phe Ala Ile Lys Asn Leu Leu Leu
530 535 540
Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn
545 550 555 560
Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala
565 570 575
Gln Ile Val Tyr Thr Glu Val Asn Leu Met Ala Asn Phe Met Pro Met
580 585 590
Asp His Asn Thr Ser Asn Gln Leu Glu Leu Met Leu Arg Asn Ala Thr
595 600 605
Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly Ala Lys Asn Ala Leu Tyr
610 615 620
Asn Val Pro Ala Gly Ser Thr Leu Leu Thr Ile Asn Ile Pro Ala Arg
625 630 635 640
Thr Trp Glu Gly Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Ser
645 650 655
Glu Thr Pro Gln Leu Gly Ala Gln Tyr Asp Val Gly Phe Lys Tyr Ser
660 665 670
Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe Tyr Leu Ser His Thr Phe
675 680 685
Arg Ser Met Ser Val Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn
690 695 700
Asp Arg Leu Leu Thr Pro Asn Leu Phe Glu Ile Lys Arg Pro Val Ala
705 710 715 720
Thr Asp Ser Glu Gly Phe Thr Met Ser Gln Cys Asp Met Thr Lys Asp
725 730 735
Trp Phe Leu Val Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly
740 745 750
Tyr Arg Phe Trp Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg
755 760 765
Asn Phe Asp Pro Met Ser Arg Gln Gly Pro Asn Phe Leu Asp Thr Thr
770 775 780
Leu Tyr Asp Leu Val Ser Ser Thr Pro Val Val Asn Asp Thr Gly Ser
785 790 795 800
Gln Pro Ser Gln Asp Asn Val Arg Asn Asn Ser Gly Phe Ile Ala Pro
805 810 815
Arg Ser Trp Pro Val Trp Thr Ala Gln Gln Gly Glu Ala Trp Pro Ala
820 825 830
Asn Trp Pro Tyr Pro Leu Ile Gly Asn Asp Ala Ile Ser Ser Asn Gln
835 840 845
Thr Val Asn Tyr Lys Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Val
850 855 860
Pro Phe Ser Ser Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly
865 870 875 880
Gln Asn Pro Met Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Phe
885 890 895
Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr Val Tyr Met Leu Tyr Gly
900 905 910
Val Phe Asp Thr Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala
915 920 925
Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Asn Ala Val
930 935 940
<210> 63
<211> 942
<212> PRT
<213> 禽腺病毒A（Fowl adenovirus A）
<400> 63
Met Thr Ala Leu Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln
1 5 10 15
Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp
20 25 30
Leu Gln Gln Phe Ile Ser Ala Thr Gly Ser Tyr Phe Asp Leu Lys Asn
35 40 45
Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu
50 55 60
Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Ile Gln Thr Asp Asp
65 70 75 80
Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Val Asn Val Gly Asp Ser
85 90 95
Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu
100 105 110
Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro
115 120 125
Leu Ala Pro Arg Glu Ala Ile Phe Asn Thr Trp Val Glu Ser Thr Gly
130 135 140
Pro Gln Thr Asn Val Val Gly Gln Met Thr Asn Val Tyr Thr Asn Gln
145 150 155 160
Thr Arg Asn Asp Lys Thr Ala Thr Leu Gln Gln Val Asn Ser Ile Ser
165 170 175
Gly Val Val Pro Asn Val Asn Leu Gly Pro Gly Leu Ser Gln Leu Ala
180 185 190
Ser Arg Ala Asp Val Asp Asn Ile Gly Val Val Gly Arg Phe Ala Lys
195 200 205
Val Asp Ser Ala Gly Val Lys Gln Ala Tyr Gly Ala Tyr Val Lys Pro
210 215 220
Val Lys Asp Asp Gly Ser Gln Ser Leu Asn Gln Thr Ala Tyr Trp Leu
225 230 235 240
Met Asp Asn Gly Gly Thr Asn Tyr Leu Gly Ala Leu Ala Val Glu Asp
245 250 255
Tyr Thr Gln Thr Leu Ser Tyr Pro Asp Thr Val Leu Val Thr Pro Pro
260 265 270
Thr Ala Tyr Gln Gln Val Asn Ser Gly Thr Met Arg Ala Cys Arg Pro
275 280 285
Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp
290 295 300
Ser Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met Asn
305 310 315 320
Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr
325 330 335
Met Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn
340 345 350
Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp
355 360 365
Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Leu Pro Asp Gly His
370 375 380
Gly Ala Gly Glu Asp Asn Gly Pro Asp Leu Ser Asn Val Lys Ile Tyr
385 390 395 400
Thr Asn Gly Gln Gln Asp Lys Gly Asn Val Val Ala Gly Thr Val Ser
405 410 415
Thr Gln Leu Asn Phe Gly Thr Ile Pro Ser Tyr Glu Ile Asp Ile Ala
420 425 430
Ala Ala Thr Arg Arg Asn Phe Ile Met Ser Asn Ile Ala Asp Tyr Leu
435 440 445
Pro Asp Lys Tyr Lys Phe Ser Ile Arg Gly Phe Asp Pro Val Thr Asp
450 455 460
Asn Ile Asp Pro Thr Thr Tyr Phe Tyr Met Asn Arg Arg Val Pro Leu
465 470 475 480
Thr Asn Val Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Trp Ser Val
485 490 495
Asp Gln Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly
500 505 510
Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Arg Phe
515 520 525
His Ile Gln Val Pro Gln Lys Tyr Phe Ala Ile Lys Asn Leu Leu Leu
530 535 540
Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn
545 550 555 560
Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala
565 570 575
Gln Ile Val Tyr Thr Glu Val Asn Leu Met Ala Asn Phe Met Pro Met
580 585 590
Asp His Asn Thr Ser Asn Gln Leu Glu Leu Met Leu Arg Asn Ala Thr
595 600 605
Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly Ala Lys Asn Ala Leu Tyr
610 615 620
Asn Val Pro Ala Gly Ser Thr Leu Leu Thr Ile Asn Ile Pro Ala Arg
625 630 635 640
Thr Trp Glu Gly Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Ser
645 650 655
Glu Thr Pro Gln Leu Gly Ala Gln Tyr Asp Val Gly Phe Lys Tyr Ser
660 665 670
Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe Tyr Leu Ser His Thr Phe
675 680 685
Arg Ser Met Ser Val Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn
690 695 700
Asp Arg Leu Leu Thr Pro Asn Leu Phe Glu Ile Lys Arg Pro Val Ala
705 710 715 720
Thr Asp Ser Glu Gly Phe Thr Met Ser Gln Cys Asp Met Thr Lys Asp
725 730 735
Trp Phe Leu Val Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly
740 745 750
Tyr Arg Phe Trp Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg
755 760 765
Asn Phe Asp Pro Met Ser Arg Gln Gly Pro Asn Phe Leu Asp Thr Thr
770 775 780
Leu Tyr Asp Leu Val Ser Ser Thr Pro Val Val Asn Asp Thr Gly Ser
785 790 795 800
Gln Pro Ser Gln Asp Asn Val Arg Asn Asn Ser Gly Phe Ile Ala Pro
805 810 815
Arg Ser Trp Pro Val Trp Thr Ala Gln Gln Gly Glu Ala Trp Pro Ala
820 825 830
Asn Trp Pro Tyr Pro Leu Ile Gly Asn Asp Ala Ile Ser Ser Asn Gln
835 840 845
Thr Val Asn Tyr Lys Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Val
850 855 860
Pro Phe Ser Ser Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly
865 870 875 880
Gln Asn Pro Met Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Phe
885 890 895
Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr Val Tyr Met Leu Tyr Gly
900 905 910
Val Phe Asp Thr Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala
915 920 925
Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Asn Ala Val
930 935 940
<210> 64
<211> 948
<212> PRT
<213> 禽腺病毒D（Fowl adenovirus D）
<400> 64
Met Ala Ala Phe Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln
1 5 10 15
Tyr Phe His Ile Ala Gly Pro Ser Thr Arg Glu Tyr Leu Ser Glu Asp
20 25 30
Leu Gln Gln Phe Ile Ala Ala Thr Gly Ser Tyr Phe Glu Leu Lys Asn
35 40 45
Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu
50 55 60
Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Thr Gln Thr Asp Asp
65 70 75 80
Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Leu Asn Val Gly Asp Ser
85 90 95
Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu
100 105 110
Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro
115 120 125
Leu Ala Pro Arg Glu Ala Phe Phe Asn Asn Trp Leu Glu Ser Glu Pro
130 135 140
Asn Lys Thr Val Ile Thr Gly Leu Met Thr Thr Pro Tyr Arg Asn Asp
145 150 155 160
Gln Gly Asn Lys Thr Asn Thr Ala Asp Val Val Asn Ser Val Ser Gly
165 170 175
Val Tyr Pro Asn Pro Asn Leu Gly Pro Cys Ile Ser Glu Met Gly Ala
180 185 190
Leu Asp Asp Ala Thr Ala Asp Leu Val Gly Phe Ala Gly Arg Phe Ala
195 200 205
Lys Val Thr Asn Glu Asn Thr Arg Leu Ala Tyr Gly Ala Tyr Val Lys
210 215 220
Pro Leu Lys Asn Asp Gly Ser Gln Ser Leu Asn Pro Thr Pro Tyr Trp
225 230 235 240
Val Met Asp Lys Thr Asp Ala Lys Tyr Leu Gly Val Met Ala Val Glu
245 250 255
Glu Phe Ser Thr Ser Leu Thr Tyr Pro Asp Ser Leu Leu Ile Pro Pro
260 265 270
Pro Ser Asp Tyr Ser Thr Val Asn Thr Gly Ala Met Lys Ala Asn Arg
275 280 285
Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His
290 295 300
Asp Thr Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met
305 310 315 320
Asn Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln
325 330 335
Tyr Met Leu Ala Asp Met Met Ser Arg His His Tyr Tyr Ala Leu Trp
340 345 350
Asn Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn
355 360 365
Asp Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Ser Pro Glu Gly
370 375 380
Thr Gly Tyr Gly Ala Asn Pro Asn Ser Asn Leu Ser Phe Ala Asp Val
385 390 395 400
Lys Val His Gln Asn Gly Ala Gly Asp Lys Gly Asn Glu Ile Asn Thr
405 410 415
Gly Gly Ala Thr Tyr Ser Thr Tyr Leu Thr Val Gly Ser Val Pro Ser
420 425 430
Tyr Glu Ile Asp Leu Ala Ala Ser Gln Arg Arg Asn Phe Ile Val Ser
435 440 445
Asn Ile Ala Asp Tyr Leu Pro Asp Lys Tyr Lys Tyr Asn Ile Asp Gly
450 455 460
Phe Asn Pro Glu Thr Gly Asn Val Asp Pro Thr Thr Tyr Glu Tyr Met
465 470 475 480
Asn Arg Arg Val Pro Leu Thr Asn Val Val Asp Leu Phe Thr Thr Ile
485 490 495
Gly Ala Arg Trp Ser Ile Asp Gln Met Asp Asn Val Asn Pro Phe Asn
500 505 510
His His Arg Asn Trp Gly Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn
515 520 525
Ser Arg Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys Tyr Phe Ala
530 535 540
Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val
545 550 555 560
Leu Arg Lys Asp Pro Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp
565 570 575
Leu Arg Ala Asp Gly Ala Ser Ile Val Tyr Ser Glu Val Asn Leu Met
580 585 590
Ala Asn Phe Met Pro Met Asp His Asn Thr Ser Asn Gln Leu Glu Leu
595 600 605
Met Met Arg Asn Ala Thr Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly
610 615 620
Ala Lys Asn Ala Leu Tyr Gln Val Pro Ala Gly Ser Thr Ala Leu Thr
625 630 635 640
Ile Asn Ile Pro Ala Arg Thr Trp Glu Gly Met Arg Gly Trp Ser Phe
645 650 655
Thr Arg Val Lys Ala Ser Glu Thr Pro Gln Ile Gly Ala Gln Tyr Asp
660 665 670
Ile Asn Phe Lys Tyr Ser Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe
675 680 685
Tyr Leu Thr His Thr Phe Arg Asn Met Ser Val Leu Phe Asp Thr Ser
690 695 700
Ile Asn Trp Pro Gly Asn Asp Arg Leu Leu Ala Pro Asn Leu Phe Glu
705 710 715 720
Ile Lys Arg Asn Val Ser Ile Asn Ala Glu Gly Phe Thr Met Ser Gln
725 730 735
Cys Asn Ile Thr Lys Asp Trp Tyr Leu Ile Gln Met Ala Thr Asn Tyr
740 745 750
Asn Tyr Val Phe Asn Gly Tyr Arg Phe Trp Pro Asp Arg Gln Tyr Phe
755 760 765
His Tyr Asp Phe Leu Arg Asn Phe Asp Pro Met Thr Cys Gln Gly Pro
770 775 780
Asn Phe Gln Asp Gln Thr Leu Phe Asp Leu Met Ser Tyr Asp Pro Val
785 790 795 800
Gln Thr Pro Gly Ala Val Gln Thr Asn Gln Asp Ala Ile Arg Asn Asn
805 810 815
Ser Gly Tyr Thr Ala Pro Arg Ser Trp Pro Val Tyr Gly Ala Gln Gln
820 825 830
Gly Glu Ser Trp Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Asp Ser
835 840 845
Ser Leu Asn Pro Thr Gln Ile Val Asn Tyr Lys Lys Phe Leu Cys Asp
850 855 860
Asn Tyr Leu Trp Thr Val Pro Phe Ser Ser Asp Phe Met Tyr Met Gly
865 870 875 880
Glu Leu Thr Asp Leu Gly Gln Asn Pro Met Tyr Thr Asn Asn Ser His
885 890 895
Ser Met Val Ile Asn Phe Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr
900 905 910
Val Tyr Met Leu Tyr Gly Val Phe Asp Met Val Arg Val Asn Gln Pro
915 920 925
Glu Arg Asn Val Leu Ala Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr
930 935 940
Gly Asn Ala Val
945
<210> 65
<211> 935
<212> PRT
<213> 北方黄腹隼腺病毒（Northern Aplomado falcon adenovirus）
<400> 65
Met Ala Ala Phe Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln
1 5 10 15
Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp
20 25 30
Leu Gln Gln Phe Ile Ser Ala Thr Ser Ser Tyr Phe Asp Leu Lys Asn
35 40 45
Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu
50 55 60
Lys Ser Gln Arg Leu Gln Ile Arg Tyr Tyr Pro Thr Gln Thr Asp Asp
65 70 75 80
Thr Thr His Gly Tyr Arg Val Arg Tyr Ser Leu Thr Val Gly Asp Ser
85 90 95
Trp Val Leu Asp Met Gly Ser Thr Tyr Phe Asp Ile Lys Gly Phe Ile
100 105 110
Asp Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro
115 120 125
Leu Ala Pro Arg Glu Ser Leu Phe Asn Phe Trp Gln Glu Lys Ser Gly
130 135 140
Asn Lys Tyr Val Ser Gly Gln Leu Ser Asn Val Tyr Thr Asn Asp Asn
145 150 155 160
Ser Thr Thr Asn Ala Ser Thr Trp Glu Ser Ala Lys Asp Phe Ser Gln
165 170 175
Thr Ser Pro Asn Pro Asn Val Gly Pro Phe Val Ser Asp Pro Asn Leu
180 185 190
Leu Gly Thr Leu Glu Lys Ile Gly Val Ser Gly Arg Ile Ala Lys Val
195 200 205
Gly Ser Asn Thr Val Pro Leu Thr Tyr Gly Ala Tyr Val Lys Pro Thr
210 215 220
Ser Val Thr Gly Ser Gln Thr Ala Asp Phe Thr Arg Tyr Tyr Ile Met
225 230 235 240
Asp Ser Ala Gly Thr Lys Tyr Gln Gly Ala Val Ala Val Glu Asp Val
245 250 255
Ser His Thr Leu Ser Tyr Pro Asp Thr Leu Arg Ile Ala Pro Ala Ile
260 265 270
Glu Thr Ser Gly Val Asp Ser Gly Ile Ser Lys Ser Leu Arg Pro Asn
275 280 285
Tyr Ile Ala Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp Thr
290 295 300
Gly Ala Cys Ser Gly Thr Leu Ser Ser Glu Arg Ser Gly Met Asn Val
305 310 315 320
Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr Met
325 330 335
Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn Gln
340 345 350
Ala Val Asp Ser Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp Gly
355 360 365
Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Gln Pro Asn Gly Val Gly
370 375 380
Asn Tyr Glu Ala Gly Pro Asp Leu Ser Glu Ser Lys Leu Phe Thr Ile
385 390 395 400
Ser Ser Thr Asn His Asp Lys Glu Thr Asp Gln Asn Ala Thr Met Asn
405 410 415
Ile Ala Trp Gly Pro Val Val Ala Asn Glu Ile Cys Met Ser Ala Ala
420 425 430
Met Lys Arg Asn Phe Ile Met Thr Asn Ile Ala Glu Tyr Leu Pro Asp
435 440 445
Lys Tyr Lys Phe Asn Ile Pro Gly Phe Ser Ala Asp Asn Ala Asp Arg
450 455 460
Arg Ser Tyr Glu Tyr Met Asn His Arg Val Pro Leu Val Asn Val Val
465 470 475 480
Asp Leu Phe Thr Asn Leu Gly Ala Arg Trp Ser Val Asp Gln Met Asp
485 490 495
Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly Leu Lys Tyr Arg
500 505 510
Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Gln Phe His Ile Gln Val
515 520 525
Pro Gln Lys Tyr Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Thr
530 535 540
Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn Met Val Leu Gln
545 550 555 560
Ser Thr Leu Gly Asn Asp Leu Arg Leu Asp Gly Ala Arg Ile Val Tyr
565 570 575
Gln Glu Val Asn Leu Met Ala Ser Phe Met Pro Met Asp His Asn Thr
580 585 590
Ser Asn Gln Leu Glu Leu Met Met Arg Asn Ala Val Asn Asp Gln Thr
595 600 605
Phe Ala Asp Tyr Leu Gly Ala Lys Ser Ala Leu Tyr Ser Val Pro Ala
610 615 620
Gln Ser Thr Val Leu Thr Ile Asn Val Pro Ala Arg Thr Trp Glu Gly
625 630 635 640
Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Glu Glu Thr Pro Gln
645 650 655
Gln Gly Ala Gln Tyr Asp Ile Asn Phe Arg Tyr Ser Gly Ser Ile Pro
660 665 670
Tyr Gln Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Arg Asn Met Ser
675 680 685
Ile Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn Asp Arg Met Leu
690 695 700
Thr Pro Asn Met Phe Glu Ile Lys Arg Ser Pro Ala Ala Asp Ala Glu
705 710 715 720
Gly Tyr Gly Met Ser Gln Ser Thr Ile Thr Lys Asp Trp Phe Leu Val
725 730 735
Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly Tyr Arg Phe Trp
740 745 750
Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg Asn Phe Asp Pro
755 760 765
Met Ser Met Gln Gly Pro Asp Phe Asn Asn Thr Asp Thr Phe Asp Leu
770 775 780
Val Thr Tyr Thr His Gln Ser Pro Thr Arg His Thr Lys Thr Lys Gln
785 790 795 800
Asn Lys Lys Arg Asn Asn Ser Gly Met Val Ala Asp Arg Ala Gly Ala
805 810 815
Pro Phe Asn Lys Arg Gln Gly Gln Leu Trp Pro Ser Asn Trp Pro Tyr
820 825 830
Pro Leu Ile Gly Lys Glu Ser Leu Pro Val Glu Lys Ile Leu Asn Tyr
835 840 845
Arg Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Ile Pro Phe Ser Ser
850 855 860
Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly Gln Asn Pro Met
865 870 875 880
Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Leu Glu Met Asp Pro
885 890 895
Met Asp Glu Asn Thr Leu Val Tyr Met Leu Tyr Gly Val Phe Asp Thr
900 905 910
Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala Met Ala Tyr Phe
915 920 925
Arg Thr Pro Phe Ala Thr Gly
930 935
<210> 66
<211> 963
<212> PRT
<213> 猫腺病毒（Feline adenovirus）
<400> 66
Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser Gly
1 5 10 15
Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg
20 25 30
Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro Thr
35 40 45
Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr
50 55 60
Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr Lys
65 70 75 80
Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala
85 90 95
Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr Phe
100 105 110
Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala
115 120 125
Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Pro Thr Gln Glu Met Ala
130 135 140
Glu Glu Leu Glu Asp Glu Glu Glu Ala Glu Glu Glu Glu Ala Glu Glu
145 150 155 160
Glu Ala Glu Ala Pro Gln Ala Asp Gln Lys Val Lys Lys Thr His Val
165 170 175
Tyr Ala Gln Ala Pro Leu Ala Gly Glu Lys Ile Thr Ala Asn Gly Leu
180 185 190
Gln Ile Val Ser Asp Thr Gln Thr Glu Gly Asn Pro Val Phe Ala Asp
195 200 205
Pro Thr Tyr Gln Pro Glu Pro Gln Val Gly Glu Ser Gln Trp Asn Glu
210 215 220
Ala Glu Ala Thr Ala Ser Gly Gly Arg Val Leu Lys Lys Thr Thr Pro
225 230 235 240
Met Lys Pro Cys Tyr Gly Ser Tyr Ala Arg Pro Thr Asn Lys Asn Gly
245 250 255
Gly Gln Gly Ile Leu Val Ala Asn Asn Gln Gly Ala Leu Glu Ser Lys
260 265 270
Val Glu Met Gln Phe Phe Ala Pro Ser Gly Thr Ala Met Asn Glu Arg
275 280 285
Asn Ala Val Gln Pro Ser Ile Val Leu Tyr Ser Glu Asp Val Asn Met
290 295 300
Glu Thr Pro Asp Thr His Ile Ser Tyr Lys Pro Ser Lys Thr Asp Glu
305 310 315 320
Asn Ser Lys Ala Met Leu Gly Gln Gln Ala Met Pro Asn Arg Pro Asn
325 330 335
Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser
340 345 350
Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala
355 360 365
Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu
370 375 380
Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln
385 390 395 400
Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly
405 410 415
Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly
420 425 430
Val Thr Asp Thr Tyr Gln Gly Ile Lys Ser Asn Gly Asn Gly Asn Pro
435 440 445
Gln Asn Trp Thr Lys Asn Asp Asp Phe Ala Ala Arg Asn Glu Ile Gly
450 455 460
Val Gly Asn Asn Phe Ala Leu Glu Ile Asn Leu Asn Ala Asn Leu Trp
465 470 475 480
Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr Leu Pro Asp Lys Leu
485 490 495
Lys Tyr Thr Pro Thr Asn Val Glu Ile Ser Pro Asn Pro Asn Ser Tyr
500 505 510
Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu Val Asp Cys Tyr
515 520 525
Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met Asp Asn Val Asn
530 535 540
Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu
545 550 555 560
Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys
565 570 575
Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr
580 585 590
Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser Ser Leu
595 600 605
Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys Phe Asp Ser Ile
610 615 620
Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr
625 630 635 640
Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp
645 650 655
Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr
660 665 670
Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly
675 680 685
Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser
690 695 700
Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp
705 710 715 720
Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ala Ile Thr Phe
725 730 735
Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn
740 745 750
Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val Ala
755 760 765
Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn
770 775 780
Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu Ser Tyr Lys Asp
785 790 795 800
Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val
805 810 815
Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln Val Gly Ile Leu His
820 825 830
Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg
835 840 845
Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro Leu Ile Gly Lys
850 855 860
Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr
865 870 875 880
Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu
885 890 895
Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala Leu
900 905 910
Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr
915 920 925
Val Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg
930 935 940
Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn
945 950 955 960
Ala Thr Thr
<210> 67
<211> 931
<212> PRT
<213> 猴腺病毒1（Simian adenovirus 1）
<400> 67
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr
65 70 75 80
Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Pro Ala Glu Trp Thr Asn Ser Asp Ser Lys Val Lys Val
130 135 140
Arg Ala Gln Ala Pro Phe Val Ser Ser Tyr Gly Ala Thr Ala Ile Thr
145 150 155 160
Lys Glu Gly Ile Gln Val Gly Val Thr Leu Thr Asp Ser Gly Ser Thr
165 170 175
Pro Gln Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile Gly Glu
180 185 190
Leu Gln Trp Asn Ser Asp Val Gly Thr Asp Asp Lys Ile Ala Gly Arg
195 200 205
Val Leu Lys Lys Thr Thr Pro Met Phe Pro Cys Tyr Gly Ser Tyr Ala
210 215 220
Arg Pro Thr Asn Glu Lys Gly Gly Gln Ala Thr Pro Ser Ala Ser Gln
225 230 235 240
Asp Val Gln Asn Pro Glu Leu Gln Phe Phe Ala Ser Thr Asn Val Ala
245 250 255
Asn Thr Pro Lys Ala Val Leu Tyr Ala Glu Asp Val Ser Ile Glu Ala
260 265 270
Pro Asp Thr His Leu Val Phe Lys Pro Thr Val Thr Glu Gly Ile Thr
275 280 285
Ser Ser Glu Ala Leu Leu Thr Gln Gln Ala Ala Pro Asn Arg Pro Asn
290 295 300
Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser
305 310 315 320
Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala
325 330 335
Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met
340 345 350
Leu Asp Ala Leu Gly Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln
355 360 365
Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly
370 375 380
Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Met Ala
385 390 395 400
Val Thr Asp Thr Tyr Ser Pro Ile Lys Val Asn Gly Gly Gly Asn Gly
405 410 415
Trp Glu Ala Asn Asn Gly Val Phe Thr Glu Arg Gly Val Glu Ile Gly
420 425 430
Ser Gly Asn Met Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp
435 440 445
Arg Ser Phe Leu Tyr Ser Asn Ile Gly Leu Tyr Leu Pro Asp Ser Leu
450 455 460
Lys Ile Thr Pro Asp Asn Ile Thr Leu Pro Glu Asn Lys Asn Thr Tyr
465 470 475 480
Gln Tyr Met Asn Gly Arg Val Thr Pro Pro Gly Leu Val Asp Thr Tyr
485 490 495
Val Asn Val Gly Ala Arg Trp Ser Pro Asp Val Met Asp Ser Ile Asn
500 505 510
Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu
515 520 525
Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys
530 535 540
Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr
545 550 555 560
Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu
565 570 575
Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Arg Phe Asp Ser Ile
580 585 590
Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr
595 600 605
Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp
610 615 620
Tyr Leu Cys Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr
625 630 635 640
Ser Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly
645 650 655
Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser
660 665 670
Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp
675 680 685
Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Met Phe
690 695 700
Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn
705 710 715 720
Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val Ala
725 730 735
Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Ile Gln Met Leu Ser His
740 745 750
Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Asn Tyr Lys Asp
755 760 765
Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Ile
770 775 780
Val Asp Ser Thr Ala Tyr Thr Asn Tyr Gln Asp Val Lys Leu Pro Tyr
785 790 795 800
Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Gly Pro Thr Met Arg
805 810 815
Glu Gly Gln Ala Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Ala
820 825 830
Thr Ala Val Pro Ser Leu Thr Gln Lys Lys Phe Leu Cys Asp Arg Val
835 840 845
Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu
850 855 860
Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu
865 870 875 880
Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr
885 890 895
Val Leu Phe Glu Val Phe Asp Val Val Arg Ile His Gln Pro His Arg
900 905 910
Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn
915 920 925
Ala Thr Thr
930
<210> 68
<211> 921
<212> PRT
<213> 猴腺病毒7（Simian adenovirus 7）
<400> 68
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr
65 70 75 80
Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Pro Ser Glu Trp Thr Asp Thr Ser Asp Asn Lys Leu Lys
130 135 140
Ala Tyr Ala Gln Ala Pro Tyr Gln Ser Gln Gly Leu Thr Lys Asp Gly
145 150 155 160
Ile Gln Val Gly Leu Val Val Thr Glu Ser Gly Gln Thr Pro Gln Tyr
165 170 175
Ala Asn Lys Val Tyr Gln Pro Glu Pro Gln Ile Gly Glu Asn Gln Trp
180 185 190
Asn Leu Glu Gln Glu Asp Lys Ala Ala Gly Arg Val Leu Lys Lys Asp
195 200 205
Thr Pro Met Phe Pro Cys Tyr Gly Ser Tyr Ala Arg Pro Thr Asn Glu
210 215 220
Gln Gly Gly Gln Ala Lys Asn Gln Glu Val Asp Leu Gln Phe Phe Ala
225 230 235 240
Thr Pro Gly Asp Thr Gln Asn Thr Ala Lys Val Val Leu Tyr Ala Glu
245 250 255
Asn Val Asn Leu Glu Thr Pro Asp Thr His Leu Val Phe Lys Pro Asp
260 265 270
Asp Asp Ser Thr Ser Ser Lys Leu Leu Leu Gly Gln Gln Ala Ala Pro
275 280 285
Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met
290 295 300
Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser
305 310 315 320
Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser
325 330 335
Tyr Gln Leu Met Leu Asp Ala Leu Gly Asp Arg Ser Arg Tyr Phe Ser
340 345 350
Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile
355 360 365
Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu
370 375 380
Gly Gly Met Val Val Thr Asp Asn Tyr Asn Ser Val Thr Pro Gln Asn
385 390 395 400
Gly Gly Ser Gly Asn Thr Trp Gln Ala Asp Asn Thr Thr Phe Ser Gln
405 410 415
Arg Gly Ala Gln Ile Gly Ser Gly Asn Met Phe Ala Leu Glu Ile Asn
420 425 430
Leu Gln Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Ile Gly Leu
435 440 445
Tyr Leu Pro Asp Ser Leu Lys Ile Thr Pro Asp Asn Ile Thr Leu Pro
450 455 460
Glu Asn Lys Asn Thr Tyr Gln Tyr Met Asn Gly Arg Val Thr Pro Pro
465 470 475 480
Gly Leu Ile Asp Thr Tyr Val Asn Val Gly Ala Arg Trp Ser Pro Asp
485 490 495
Val Met Asp Ser Ile Asn Pro Phe Asn His His Arg Asn Ala Gly Leu
500 505 510
Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His
515 520 525
Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu
530 535 540
Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met
545 550 555 560
Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser
565 570 575
Ile Arg Phe Asp Ser Ile Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala
580 585 590
His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn
595 600 605
Asp Gln Ser Phe Asn Asp Tyr Leu Cys Ala Ala Asn Met Leu Tyr Pro
610 615 620
Ile Pro Ala Asn Ala Thr Ser Val Pro Ile Ser Ile Pro Ser Arg Asn
625 630 635 640
Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu
645 650 655
Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly
660 665 670
Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys
675 680 685
Lys Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp
690 695 700
Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly
705 710 715 720
Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu
725 730 735
Ile Gln Met Leu Ser His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val
740 745 750
Pro Glu Asn Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln
755 760 765
Pro Met Ser Arg Gln Val Val Asp Thr Val Thr Tyr Thr Asp Tyr Lys
770 775 780
Asp Val Lys Leu Pro Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr
785 790 795 800
Met Gly Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Tyr Pro
805 810 815
Tyr Pro Leu Ile Gly Glu Thr Ala Val Pro Ser Leu Thr Gln Lys Lys
820 825 830
Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe
835 840 845
Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala
850 855 860
Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp
865 870 875 880
Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg
885 890 895
Ile His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr
900 905 910
Pro Phe Ser Ala Gly Asn Ala Thr Thr
915 920
<210> 69
<211> 956
<212> PRT
<213> 猴腺病毒21（Simian adenovirus 21）
<400> 69
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Asp Thr Tyr Phe Asn Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Met Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr
65 70 75 80
Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Phe Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Ser Ala Tyr Asn Ser Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Thr Ser Gln Trp Leu Asp Lys Gly Val Thr Thr Thr Asp
130 135 140
Asn Asn Thr Glu Asn Gly Asp Glu Glu Asp Glu Val Ala Glu Glu Gly
145 150 155 160
Glu Glu Glu Lys Gln Ala Thr Tyr Thr Phe Gly Asn Ala Pro Val Lys
165 170 175
Ala Glu Ala Glu Ile Thr Lys Glu Gly Leu Pro Ile Gly Leu Glu Val
180 185 190
Pro Ser Glu Gly Asp Pro Lys Pro Ile Tyr Ala Asp Lys Leu Tyr Gln
195 200 205
Pro Glu Pro Gln Val Gly Glu Glu Ser Trp Thr Asp Thr Asp Gly Thr
210 215 220
Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro Glu Thr Lys Met Lys
225 230 235 240
Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Val Lys Gly Gly Gln
245 250 255
Ala Lys Val Lys Lys Val Glu Glu Gly Lys Val Glu Tyr Asp Ile Asp
260 265 270
Met Asn Phe Phe Asp Leu Arg Ser Gln Lys Thr Gly Leu Lys Pro Lys
275 280 285
Ile Val Met Tyr Ala Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His
290 295 300
Val Val Tyr Lys Pro Gly Ala Ser Asp Ala Ser Ser His Ala Asn Leu
305 310 315 320
Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp
325 330 335
Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val
340 345 350
Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp
355 360 365
Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp
370 375 380
Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp
385 390 395 400
Pro Asp Val Arg Val Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro
405 410 415
Asn Tyr Cys Phe Pro Leu Asp Gly Val Gly Pro Arg Thr Asp Ser Tyr
420 425 430
Lys Gly Ile Glu Thr Asn Gly Asp Glu Asn Thr Thr Trp Lys Asp Leu
435 440 445
Asp Pro Asn Gly Ile Ser Glu Leu Ala Lys Gly Asn Pro Phe Ala Met
450 455 460
Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn
465 470 475 480
Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Thr Asn Val
485 490 495
Thr Leu Pro Glu Asn Lys Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val
500 505 510
Val Pro Pro Ser Leu Val Asp Thr Tyr Val Asn Ile Gly Ala Arg Trp
515 520 525
Ser Leu Asp Ala Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn
530 535 540
Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val
545 550 555 560
Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Val Lys Asn Leu
565 570 575
Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp
580 585 590
Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp
595 600 605
Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe
610 615 620
Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn
625 630 635 640
Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met
645 650 655
Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro
660 665 670
Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys
675 680 685
Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val
690 695 700
Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His
705 710 715 720
Thr Phe Lys Lys Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro
725 730 735
Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr
740 745 750
Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp
755 760 765
Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly
770 775 780
Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg
785 790 795 800
Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Ile Asn Tyr Lys
805 810 815
Asp Tyr Lys Ala Val Ala Val Pro Tyr Gln His Asn Asn Ser Gly Phe
820 825 830
Val Gly Tyr Met Ala Pro Thr Met Arg Gln Gly Gln Ala Tyr Pro Ala
835 840 845
Asn Tyr Pro Tyr Pro Leu Ile Gly Thr Thr Ala Val Thr Ser Val Thr
850 855 860
Gln Lys Lys Phe Leu Cys Asp Arg Thr Met Trp Arg Ile Pro Phe Ser
865 870 875 880
Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu
885 890 895
Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp
900 905 910
Pro Met Asp Glu Pro Thr Leu Leu Tyr Leu Leu Phe Glu Val Phe Asp
915 920 925
Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr
930 935 940
Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr
945 950 955
<210> 70
<211> 949
<212> PRT
<213> 未知
<220>
<223> 不明腺病毒（Unidentified adenovirus）
<400> 70
Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Asp Thr Tyr Phe Asn Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Met Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ala Tyr
65 70 75 80
Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Phe Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Thr Ser Gln Trp Ile Ala Glu Gly Val Lys Lys Glu Asn
130 135 140
Gly Glu Ser Asp Glu Glu Glu Glu Lys Asn Leu Thr Thr Tyr Thr Phe
145 150 155 160
Gly Asn Ala Pro Val Lys Ala Glu Gly Gly Asp Ile Thr Lys Asp Lys
165 170 175
Gly Leu Pro Ile Gly Ser Glu Ile Thr Asp Gly Glu Ala Lys Pro Ile
180 185 190
Tyr Ala Asp Lys Leu Tyr Gln Pro Glu Pro Gln Val Gly Asp Glu Thr
195 200 205
Trp Thr Asp Thr Asp Gly Thr Ala Glu Lys Tyr Gly Gly Arg Ala Leu
210 215 220
Lys Pro Glu Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro
225 230 235 240
Thr Asn Val Lys Gly Gly Gln Ala Lys Gln Lys Thr Thr Glu Gln Leu
245 250 255
Gln Asn Gln Gln Val Glu Tyr Asp Ile Asp Met Asn Phe Phe Asp Gln
260 265 270
Ala Ser Gln Lys Ala Asn Phe Ser Pro Lys Ile Val Met Tyr Ala Glu
275 280 285
Asn Val Asp Leu Glu Thr Pro Asp Thr His Val Val Tyr Lys Pro Gly
290 295 300
Thr Ser Glu Glu Ser Ser His Ala Asn Leu Gly Gln Gln Ser Met Pro
305 310 315 320
Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met
325 330 335
Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser
340 345 350
Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser
355 360 365
Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser
370 375 380
Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile
385 390 395 400
Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu
405 410 415
Asp Gly Val Gly Val Pro Thr Thr Ser Tyr Lys Ile Ile Glu Pro Asn
420 425 430
Gly Glu Gly Ala Asp Trp Lys Glu Pro Asp Ile Asn Gly Thr Ser Glu
435 440 445
Ile Gly Gln Gly Asn Leu Ser Ala Met Glu Ile Asn Leu Gln Ala Asn
450 455 460
Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp
465 470 475 480
Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn
485 490 495
Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Pro Pro Ser Leu Val Asp
500 505 510
Thr Tyr Val Asn Ile Gly Ala Arg Trp Ser Leu Asp Ala Met Asp Asn
515 520 525
Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser
530 535 540
Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro
545 550 555 560
Gln Lys Phe Phe Ala Val Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr
565 570 575
Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser
580 585 590
Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Ser Phe Thr
595 600 605
Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala
610 615 620
Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe
625 630 635 640
Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn
645 650 655
Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe
660 665 670
Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu
675 680 685
Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr
690 695 700
Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile
705 710 715 720
Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr
725 730 735
Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn
740 745 750
Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu
755 760 765
Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr
770 775 780
Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg
785 790 795 800
Gln Val Val Asp Glu Ile Asn Tyr Lys Asp Tyr Lys Ala Val Ala Val
805 810 815
Pro Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Ala Pro Thr
820 825 830
Met Arg Gln Gly Gln Ala Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile
835 840 845
Gly Thr Thr Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp
850 855 860
Arg Thr Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly
865 870 875 880
Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His
885 890 895
Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu
900 905 910
Leu Tyr Leu Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro
915 920 925
His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala
930 935 940
Gly Asn Ala Thr Thr
945
<210> 71
<211> 932
<212> PRT
<213> 猴腺病毒3（Simian adenovirus 3）
<400> 71
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Glu Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Ile Arg Phe Val Pro Val Asp Lys Glu Asp Thr Ala Tyr Ser Tyr
65 70 75 80
Lys Thr Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Ile Asp Arg Gly Pro Ser
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Asn Cys Gln Trp Gln Ser Gly Val Gln Pro Lys Val Asn
130 135 140
Thr Tyr Gly Gln Ala Ala Phe Ile Asn Asp Phe Val Asp Asn Asn Asn
145 150 155 160
Gly His Thr Gly Ile Lys Val Gly Asp Asn Ala Glu Gly Gln Pro Ile
165 170 175
Val Ala Asp Pro Thr Phe Gln Pro Glu Pro Gln Thr Gly Gly Leu Asp
180 185 190
Thr Gln Trp Asn Thr Val Pro Asn Thr Asn Asn Leu Lys Leu Glu Ala
195 200 205
Ala Gly Arg Ala Leu Lys Tyr Thr Thr Pro Met Lys Pro Cys Tyr Gly
210 215 220
Ser Tyr Ala Arg Pro Thr Asn Glu Asn Gly Gly Gln Gly Thr Leu Gly
225 230 235 240
Asn Asn Gly Lys Thr Thr Pro Ala Glu Leu Gln Phe Phe Asp Leu Ala
245 250 255
Ser Lys Asn Asn Asp Tyr Ser Pro Ala Val Thr Met Tyr Thr Glu Asp
260 265 270
Val Tyr Leu Glu Thr Pro Asp Thr His Ile Ile Tyr Asn Pro Glu Thr
275 280 285
Val Asn Gly Asn Thr Asn Thr Gln Leu Leu Leu Gly Gln Gln Ala Ala
290 295 300
Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Phe
305 310 315 320
Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala
325 330 335
Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu
340 345 350
Ser Tyr Gln Leu Met Leu Asp Ala Leu Gly Asp Arg Thr Arg Tyr Phe
355 360 365
Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile
370 375 380
Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro
385 390 395 400
Leu Ser Ala Val Gly Ile Val Asn Asp Tyr Lys Gly Ile Thr Lys Asn
405 410 415
Gly Gly Asn Trp Gln Val Asp Gln Thr Asp Ser Asp Arg Asn Glu Ile
420 425 430
Ala Thr Gly Asn Ile Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu
435 440 445
Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser
450 455 460
Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Glu Asn Lys Asn Thr
465 470 475 480
Tyr Gly Tyr Ile Asn Gly Arg Ile Thr Ala Pro Gly Leu Ile Asp Thr
485 490 495
Tyr Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Pro Met Asp Asn Val
500 505 510
Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met
515 520 525
Leu Leu Gly Asn Gly Arg Val Val Pro Phe His Ile Gln Val Pro Gln
530 535 540
Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr
545 550 555 560
Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Thr
565 570 575
Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Val Arg Ile Asp Ser
580 585 590
Val Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala His Asn Thr Ala Ser
595 600 605
Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn
610 615 620
Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala
625 630 635 640
Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg
645 650 655
Gly Trp Ser Phe Thr Arg Leu Lys Ala Lys Glu Thr Pro Ser Leu Gly
660 665 670
Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Thr Ile Pro Tyr Leu
675 680 685
Asp Gly Ser Phe Tyr Leu Asn His Thr Phe Lys Arg Leu Ser Ile Met
690 695 700
Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro
705 710 715 720
Asn Glu Phe Glu Ile Lys Arg Val Val Asp Gly Glu Gly Tyr Asn Val
725 730 735
Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Ile Gln Met Leu Ser
740 745 750
His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys
755 760 765
Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln
770 775 780
Ile Val Asp Pro Thr Ser Tyr Thr Ala Tyr Gln Ala Val Ala Leu Pro
785 790 795 800
His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Gly Pro Thr Ile
805 810 815
Arg Glu Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly
820 825 830
Ala Thr Ala Val Pro Ala Ile Thr Gln Lys Lys Phe Leu Cys Asp Arg
835 840 845
Val Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala
850 855 860
Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala
865 870 875 880
Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu
885 890 895
Tyr Met Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His
900 905 910
Arg Gly Ile Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly
915 920 925
Asn Ala Thr Thr
930
<210> 72
<211> 903
<212> PRT
<213> 马腺病毒2（Equine adenovirus 2）
<400> 72
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Ile Val Gln Phe Ala
20 25 30
Gln Ala Arg Lys Pro Tyr Phe His Leu Gly Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Glu Arg Thr Thr Glu Arg Phe Ala Glu Ala
50 55 60
Cys Ser Cys Ala Phe Val Pro Val Asp Lys Glu Asp Thr Val Tyr Thr
65 70 75 80
Tyr Lys Thr Arg Phe Gln Leu Ala Val Gly Asn Asn Arg Val Leu Asp
85 90 95
Met Gly Arg Thr Tyr Phe Tyr Ile Arg Gly Thr Leu Asp Arg Gly Pro
100 105 110
Ser Phe Lys Pro Tyr Ser Gly Thr Gln Tyr Asn Gln Leu Ala Pro Lys
115 120 125
Gly Ala Pro Asn Pro Cys Gln Tyr Gln Lys Asn Asn Thr Thr Val Thr
130 135 140
Phe Gly Gln Ala Ala Phe Glu Gly Val Glu Ile Thr Ala Ser Gly Leu
145 150 155 160
Arg Ile Ala Val Asp Lys Tyr Cys Asp Pro Thr Tyr Gln Pro Glu Pro
165 170 175
Gln Ile Gly Ile Asp Ser Trp Glu Pro Gly Thr Thr Leu Ser Asp Asp
180 185 190
Ile Ala Ala Val Gly Gly Arg Val Leu Asn Asn Gln Gln Asn Pro Thr
195 200 205
Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asp Gly Gly Gln
210 215 220
Gly Asp Gly Asn Pro Thr Leu Lys Phe Phe Lys Thr Gly Thr Gln Ala
225 230 235 240
Ala Arg Pro Asp Ile Val Leu Tyr Ser Glu Asn Val Asn Leu Met Met
245 250 255
Pro Asp Ser His Ile Val Tyr Lys Val Gly Thr Asp Glu Glu Gln Ser
260 265 270
Arg Ala Ala Leu Ala Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Val
275 280 285
Ala Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn Gly
290 295 300
Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val
305 310 315 320
Asp Leu Gln Asn Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp
325 330 335
Ser Leu Val Asp Arg Asn Arg Tyr Phe Ala Met Trp Asn Gln Ala Val
340 345 350
Asp Ser Tyr Asp Pro Asp Val Arg Ile Val Glu Asn Val Gly Val Glu
355 360 365
Asp Glu Met Pro Asn Tyr Ala Tyr Pro Leu Ser Gly Met Asn Pro Thr
370 375 380
Ala Ala Asn Arg Asn Ser Trp Arg Ser Arg Val Pro Asn Glu Glu Gly
385 390 395 400
Trp Val Ser Lys Gly Asn Leu Asp Ala Leu Glu Leu Asn Ile Pro Ala
405 410 415
Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Val Ala Met Tyr Leu Pro
420 425 430
Asp Lys Tyr Lys Phe Thr Pro Pro Asn Thr Thr Leu Pro Glu Asn Glu
435 440 445
Asn Thr Tyr Asp Tyr Met Asn Gly Lys Leu Pro Ala Ala Gly Leu Ile
450 455 460
Asp Ser Tyr Val Asn Val Gly Ser Arg Trp Ser Leu Asp Val Met Asp
465 470 475 480
Asn Ile Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg
485 490 495
Ser Gln Ile Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val
500 505 510
Pro Gln Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr
515 520 525
Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln
530 535 540
Ser Thr Leu Gly Asn Gly Leu Arg Val Asp Gly Ala Ser Ile Thr Tyr
545 550 555 560
Glu Asn Ile Thr Leu Tyr Ala Ser Phe Phe Pro Met Ala His Asn Thr
565 570 575
Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser
580 585 590
Phe Ile Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Thr Ile Pro Ala
595 600 605
Gly Ala Thr Gln Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala
610 615 620
Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Ala Lys Glu Thr Pro Ala
625 630 635 640
Leu Gly Ser Pro Phe Glu Pro Tyr Phe Asn Tyr Ser Gly Thr Ile Pro
645 650 655
Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Arg Arg Val Ser
660 665 670
Val Gln Phe Asp Ser Ser Ala Leu Gly Pro Glu Thr Thr Val Phe Phe
675 680 685
Thr Pro Asn Glu Phe Glu Ile Lys Arg Leu Ile Asp Gly Glu Gly Tyr
690 695 700
Asn Val Ser Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met
705 710 715 720
Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro Glu Ser
725 730 735
Tyr Lys Asp Arg Trp Tyr Gly Pro Leu Arg Asn Phe Gln Pro Leu Cys
740 745 750
Arg Gln Val Pro Asp Pro Leu Arg Phe Thr Asp Tyr Lys Ala Val Ser
755 760 765
Val Leu Asn Gln His Asn Asn Ser Gly Phe Thr Gly Tyr Asn Ser Ala
770 775 780
Gly Leu Met Arg Glu Gly Gln Pro Tyr Pro Ala Asn Trp Pro Tyr Pro
785 790 795 800
Leu Ile Gly Lys Asn Ala Val Ala Ser Val Thr Glu Arg Lys Phe Leu
805 810 815
Cys Asp Lys Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser
820 825 830
Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ala
835 840 845
Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Glu Glu Pro
850 855 860
Thr Leu Leu Tyr Leu Leu Phe Gln Val Phe Glu Val Ala Arg Val His
865 870 875 880
Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr Pro Phe
885 890 895
Ser Ala Gly Asn Ala Thr Thr
900
<210> 73
<211> 952
<212> PRT
<213> 人腺病毒5（Human adenovirus 5）
<400> 73
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr
65 70 75 80
Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile
130 135 140
Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln
145 150 155 160
Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly
165 170 175
Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr
180 185 190
Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu
195 200 205
Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu
210 215 220
Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro
225 230 235 240
Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly
245 250 255
Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala
260 265 270
Thr Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser
275 280 285
Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro
290 295 300
Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met
305 310 315 320
Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu
325 330 335
Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala
340 345 350
Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu
355 360 365
Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe
370 375 380
Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile
385 390 395 400
Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro
405 410 415
Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys
420 425 430
Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp
435 440 445
Lys Asn Glu Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu
450 455 460
Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr
465 470 475 480
Leu Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp
485 490 495
Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly
500 505 510
Leu Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr
515 520 525
Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg
530 535 540
Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile
545 550 555 560
Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro
565 570 575
Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val
580 585 590
Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile
595 600 605
Lys Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His
610 615 620
Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp
625 630 635 640
Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile
645 650 655
Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp
660 665 670
Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr
675 680 685
Pro Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser
690 695 700
Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys
705 710 715 720
Val Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg
725 730 735
Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu
740 745 750
Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val
755 760 765
Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro
770 775 780
Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro
785 790 795 800
Met Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln
805 810 815
Val Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu
820 825 830
Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr
835 840 845
Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe
850 855 860
Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met
865 870 875 880
Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn
885 890 895
Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu
900 905 910
Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val
915 920 925
His Arg Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro
930 935 940
Phe Ser Ala Gly Asn Ala Thr Thr
945 950
<210> 74
<211> 382
<212> PRT
<213> 绵羊腺病毒7（Ovine adenovirus 7）
<400> 74
Met Ser Ser Lys Lys Val Thr Lys Ser Ile Lys Lys Arg Lys Ser Thr
1 5 10 15
Thr Glu Glu Phe Gln Asn Lys Val Gln Ala Ala Leu Glu Ile Leu Ala
20 25 30
Lys Phe Gly Glu Cys Val Lys Val Asp Thr Ser Gln Met Lys Phe His
35 40 45
Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ala Gln Tyr Met Lys Lys
50 55 60
Met Lys Ile Ile Asn Leu Thr Tyr Ser Ser Ser Lys Ser Met Ala Thr
65 70 75 80
Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Asp Leu
85 90 95
Ile Pro Asn Phe Asn Ala Ser Gly Cys Tyr Leu Trp Tyr His Asp Trp
100 105 110
Glu Glu Asp Arg Pro Arg Cys Phe His Gly Asp Phe Met Phe Lys Arg
115 120 125
Val Asn Glu Ile Glu Met Pro Pro Thr Ser Glu Ala Gly Val Gln Ala
130 135 140
Leu Lys Glu Gly Arg Gly Val Leu Ser Asn Gly Arg Met Asn Lys Gln
145 150 155 160
Val Val Lys Ile Val Gln Glu His Tyr Val Leu Cys Ala Glu Asp Ala
165 170 175
His Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe
180 185 190
Ser Asp Glu Lys Lys Ala Leu Leu Ala Met Gln Asn Ala Ile Glu Thr
195 200 205
Thr Lys Ala Val Phe Pro Lys Ala Lys Val Gly Asn Met Leu Phe Ile
210 215 220
Leu Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Gln Thr Ile Gly Lys
225 230 235 240
Gln Leu Pro Lys Ile Thr Pro Phe Ser Ile Ser Gly Val Glu Gly Ile
245 250 255
Asp Val Gln Asp Val Asn Arg Val Gln Ala Ala Ala Val Thr Phe Pro
260 265 270
Ala Val Phe Val Phe Gln Cys Cys Asn Tyr Gln Tyr Asn Leu Arg Arg
275 280 285
Asn Asn Gly Lys Phe Cys Glu Met Lys Ile Ser Leu Pro Asp Met Leu
290 295 300
Gln Cys Leu Thr Leu Val Arg Lys Phe Trp Asn Glu Cys Met Gly Asn
305 310 315 320
Asn Ile Pro Ile Gln Phe Ser Gln Phe Lys Trp Asn Gln Ser Phe Gln
325 330 335
Val Lys Asn Thr Met Leu Pro Asn Ile Glu Glu Asp Ser Asp Met Asn
340 345 350
Pro Phe Gly Thr Ile Glu Glu Pro Thr Pro Ser Lys Lys Lys Lys Thr
355 360 365
Ile Leu Glu Ser Ser Ser Glu Glu Glu Asp Glu Asp Glu Asp
370 375 380
<210> 75
<211> 380
<212> PRT
<213> 牛腺病毒4（Bovine adenovirus 4）
<400> 75
Met Ser Thr Lys Lys Gly Ser Lys Leu Ala Arg Lys Gly Arg Ser Glu
1 5 10 15
Asn Glu Glu Thr Gln Gln Lys Ile Gln Ala Ala Leu Glu Ile Val Ser
20 25 30
Lys Phe Gly Glu Tyr Val Lys Val Glu Thr Ser Gln Met Lys Phe His
35 40 45
Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ser Gln Tyr Leu Lys Lys
50 55 60
His Lys Ser Ile Asn Leu Thr Tyr Ser Asn Phe Lys Ser Met Ala Ile
65 70 75 80
Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Gly Leu
85 90 95
Val Pro Asn Phe Asn Val Thr Gly Cys Tyr Leu Trp Tyr His Asp Trp
100 105 110
Asp Glu Arg Pro Arg Cys Phe His Gly Asp Phe Met Leu Lys Lys Val
115 120 125
Asn Glu Ile Glu Met Ser Pro Thr Ser Glu Met Gly Ile Gln Ala Leu
130 135 140
Lys Glu Gly Arg Gly Ile Leu Cys Asn Gly Lys Met Asn Lys Gln Val
145 150 155 160
Val Lys Val Val Gln Glu Asn Phe Met Leu Cys Ser Glu Asp Ala Gln
165 170 175
Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe Ser
180 185 190
Asp Glu Lys Lys Ala Leu Ile Ala Met Gln Asn Ala Phe Gln Thr Thr
195 200 205
Lys Ala Val Phe Pro Asn Ala Lys Ile Gly Asn Met Leu Phe Ile Leu
210 215 220
Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Leu Val Ile Gly Lys Gln
225 230 235 240
Leu Pro Lys Ile Thr Ala Tyr Thr Ile Thr Gly Val Glu Gly Ile Asp
245 250 255
Ala Gln Asp Val Ser Lys Val Gln Ala Ala Ala Val Met Tyr Pro Ala
260 265 270
Val Phe Val Phe Gln Cys Cys Asn Phe Gln Phe Thr Ser Lys Arg Asn
275 280 285
Thr Thr Lys Phe Cys Glu Met Lys Ile Ser Val Pro Asp Met Leu Gln
290 295 300
Cys Leu Thr Leu Val Arg Lys Phe Trp Phe Glu Cys Met Gly Thr Pro
305 310 315 320
Leu Pro Ile Asn Phe Pro Gln Phe Lys Trp Asn Gln Cys Phe Gln Val
325 330 335
Lys Asn Thr Val Leu Pro Ser Ile Glu Glu Asp Val Glu Ala Asn Pro
340 345 350
Phe Gly Glu Val Glu Glu Ala Pro Pro Lys Lys Lys Lys Arg Thr Val
355 360 365
Leu Glu Ser Ser Ser Glu Glu Asp Asp Glu Asp Asp
370 375 380
<210> 76
<211> 380
<212> PRT
<213> 牛腺病毒D（Bovine adenovirus D）
<400> 76
Met Ser Thr Lys Lys Gly Ser Lys Leu Ala Arg Lys Gly Arg Ser Glu
1 5 10 15
Asn Glu Glu Thr Gln Gln Lys Ile Gln Ala Ala Leu Glu Ile Val Ser
20 25 30
Lys Phe Gly Glu Tyr Val Lys Val Glu Thr Ser Gln Met Lys Phe His
35 40 45
Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ser Gln Tyr Leu Lys Lys
50 55 60
His Lys Ser Ile Asn Leu Thr Tyr Ser Asn Phe Lys Ser Met Ala Ile
65 70 75 80
Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Gly Leu
85 90 95
Val Pro Asn Phe Asn Val Thr Gly Cys Tyr Leu Trp Tyr His Asp Trp
100 105 110
Asp Glu Arg Pro Arg Cys Phe His Gly Asp Phe Met Leu Lys Lys Val
115 120 125
Asn Glu Ile Glu Met Ser Pro Thr Ser Glu Met Gly Ile Gln Ala Leu
130 135 140
Lys Glu Gly Arg Gly Ile Leu Cys Asn Gly Lys Met Asn Lys Gln Val
145 150 155 160
Val Lys Val Val Gln Glu Asn Phe Met Leu Cys Ser Glu Asp Ala Gln
165 170 175
Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe Ser
180 185 190
Asp Glu Lys Lys Ala Leu Ile Ala Met Gln Asn Ala Phe Gln Thr Thr
195 200 205
Lys Ala Val Phe Pro Asn Ala Lys Ile Gly Asn Met Leu Phe Ile Leu
210 215 220
Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Leu Val Ile Gly Lys Gln
225 230 235 240
Leu Pro Lys Ile Thr Ala Tyr Thr Ile Thr Gly Val Glu Gly Ile Asp
245 250 255
Ala Gln Asp Val Ser Lys Val Gln Ala Ala Ala Val Met Tyr Pro Ala
260 265 270
Val Phe Val Phe Gln Cys Cys Asn Phe Gln Phe Thr Ser Lys Arg Asn
275 280 285
Thr Thr Lys Phe Cys Glu Met Lys Ile Ser Val Pro Asp Met Leu Gln
290 295 300
Cys Leu Thr Leu Val Arg Lys Phe Trp Phe Glu Cys Met Gly Thr Pro
305 310 315 320
Leu Pro Ile Asn Phe Pro Gln Phe Lys Trp Asn Gln Cys Phe Gln Val
325 330 335
Lys Asn Thr Val Leu Pro Ser Ile Glu Glu Asp Val Glu Ala Asn Pro
340 345 350
Phe Gly Glu Val Glu Glu Ala Pro Pro Lys Lys Lys Lys Arg Thr Val
355 360 365
Leu Glu Ser Ser Ser Glu Glu Asp Asp Glu Asp Asp
370 375 380
<210> 77
<211> 387
<212> PRT
<213> 鸭腺病毒A（Duck adenovirus A）
<400> 77
Met Ser Ser Lys Lys Ser Thr Ala Thr Ser Ser Lys Lys Ala Lys Arg
1 5 10 15
Ser Ala Gly Leu Thr Asp Thr Glu Leu Glu Arg Gln Gln Asn Glu Ser
20 25 30
Leu Phe Gln Ala Ala Leu Glu Val Val Tyr Lys Leu Gly Glu His Leu
35 40 45
Lys Val Glu Thr Lys Asp Val Thr Phe His Pro Phe Asp Thr Gly Leu
50 55 60
Glu Lys Leu Phe Ala Gln Thr Leu Lys Lys Ala Lys Tyr Thr Pro Ile
65 70 75 80
Tyr Ser Ala Ala Lys Ser Met Asn Val Val Gly Gly Arg Leu Leu Tyr
85 90 95
Gly Ala Ile Cys Asn Tyr Val Gly Leu Ala Pro Asn Phe Asn Pro Thr
100 105 110
Gly Cys Ser Leu Trp Glu His Gly Trp Glu Glu Gly Val Arg Cys Tyr
115 120 125
His Ser Glu Lys Met Ile Leu Lys Glu Asn Ile Ile Glu Met Thr Pro
130 135 140
Thr Ser Glu Ala Ala Ile Ser Ala Leu Lys Glu Gly Arg Gly Leu Leu
145 150 155 160
Ser Ser Asn Lys Tyr Gly Lys Gln Val Val Arg Ile Val Gln Glu Asn
165 170 175
Ser Met Ile Cys Pro Glu Asp Leu Arg Gln Thr Arg Phe Gly Thr Phe
180 185 190
Ser Asn Ser Ser Cys Gly Leu Asn Phe Thr Asp Gly Glu Lys Ala Lys
195 200 205
Leu Ala Tyr Lys Asn Ala Thr Ala Tyr Ile Gln Ala Val Phe Pro Lys
210 215 220
Thr Ala Met Gln His Leu Leu Phe Ile Val Thr Ala Cys Glu Cys Asn
225 230 235 240
Tyr Gly Gly Gln Leu Ile Leu Gly Lys Gln Ile Pro Lys Met Thr Pro
245 250 255
Tyr Thr Val Ser Gly Val Glu Asn Ile Ser Val Lys Asp Leu Asp Pro
260 265 270
Val Lys Ala Val Gly Val Lys Tyr Pro Ala Val Phe Val Phe Gln Cys
275 280 285
Cys Asn Phe Gln Gly Gln Lys Arg Ala Gly Asn Ala Lys Ser Cys Glu
290 295 300
Phe Lys Ile Ser Leu Pro Asp Leu Ile His Cys Leu Ile Thr Ala Arg
305 310 315 320
Asn Leu Trp Phe Glu Val Met Gly Glu Pro Met Pro Val Gln Phe Pro
325 330 335
Leu Phe Lys Trp Ser Pro Ala Leu Gln Val Lys Asn Thr Leu Leu Pro
340 345 350
Ser Cys Asp Val Cys Thr Glu Asp Asn Pro Phe Gly Glu Ile Pro Thr
355 360 365
Lys Arg Lys Arg Val Val Glu Ile Glu Ser Asp Glu Asp Glu Glu Glu
370 375 380
Asp Glu Asp
385
<210> 78
<211> 397
<212> PRT
<213> 蛇腺病毒（Snake adenovirus）
<400> 78
Met Ser Leu Ser Lys Thr Lys Asn Pro Ala Leu Leu Ala Gly Pro Gly
1 5 10 15
Asp Glu Ala Lys Glu Lys Val Gln Ala Ala Leu Glu Leu Leu His Lys
20 25 30
Phe Gly Ser Ala Phe Lys Val Asp Thr Ala Gly Phe Ser Phe His Pro
35 40 45
Glu Ser Pro Glu Cys Asp Lys Ile Phe Gly Ala Tyr Leu Lys Asn Val
50 55 60
Lys His Val Pro Thr Tyr Ser Ser Ala Lys Thr Leu Thr Ser Val Gly
65 70 75 80
Gly Arg Ile Leu Tyr Ala Ala Thr Cys Gln Tyr Val Lys Leu Thr Pro
85 90 95
Val Thr Asn Leu Thr Gly Cys Thr Leu Trp Glu His Gly Trp Gly Gln
100 105 110
Asn Leu Lys Cys Tyr His Gly Glu Gly Met Cys Arg Lys Lys Asn Glu
115 120 125
Ile Glu Met Ala Ala Thr Ser Glu Ser Gly Val Ala Ala Leu Lys Glu
130 135 140
Gly Arg Gly Ala Val Glu Ile Asn Arg Trp Gly Arg Gln Val Val Lys
145 150 155 160
Ile Thr Gln Glu Asn Tyr Val Ile Cys Met Glu Asp Leu Gln Ser Arg
165 170 175
Phe Asn Gln Pro Ser Ala Asn Ser Cys Gly Leu Ser Phe Ser Asp Ser
180 185 190
Asp Lys Ala Arg Ser Ala Met Glu Asn Ala Thr Glu Leu Thr Arg Ser
195 200 205
Ile Phe Ser Gln Ala Lys Met Asp His Leu Leu Phe Met Pro Ile Cys
210 215 220
Cys Tyr Cys Asn Tyr Gly Gly Lys Met Ile Leu Gly Arg Gln Leu Cys
225 230 235 240
Lys Leu Thr Pro Phe Ser Ile Ser Gly Thr Glu Gly Leu Arg Glu Glu
245 250 255
Asp Val Ser Pro Val Gln Ala Val Ser Val Arg His Pro Ala Val Phe
260 265 270
Val Phe Gln Cys Cys Asn Ala Thr Gly Gly Ser Lys Gly Lys Thr Ser
275 280 285
Cys Asp Phe Lys Ile Ser His Ala Asp Leu Leu Gln Val Leu Asn Leu
290 295 300
Val Arg Lys Met Trp Leu Glu Val Met Gly Tyr Pro Met Pro Ile His
305 310 315 320
Phe Pro Arg Phe Lys Trp Ser Pro Ser Leu Arg Val Lys Asn Ala Leu
325 330 335
Leu Pro Glu Gly Ser Val Asn Glu Asp Glu Asn Pro Phe Gly Leu Asp
340 345 350
Asn Ser Glu Asp Glu Glu Glu Val Val Pro Pro Ser Pro Pro Ser Pro
355 360 365
Ala Arg Lys Arg Thr Arg Thr Thr Val Ala Glu Val His His Lys Lys
370 375 380
Lys Lys Lys Ile Val Leu Glu Ser Ser Glu Glu Asp Glu
385 390 395
<210> 79
<211> 441
<212> PRT
<213> 禽腺病毒1（fowl adenovirus 1）
<400> 79
Met Glu Arg Thr Pro Lys Arg Ala His Gly Phe Arg Ser Thr Lys Pro
1 5 10 15
Val Lys Arg Thr Ala Glu Val Met Met Glu Glu Glu Glu Glu Glu Val
20 25 30
Glu Val Val Ala Pro Gly Arg Gly Ala Thr Arg Lys Lys Val Ser Arg
35 40 45
Arg Glu Glu Ser Pro Ser Pro Val Arg Arg Val Thr Arg Arg Arg Glu
50 55 60
Thr Val Val Asp Asp Glu Glu Asn Ala Ser Asp Glu Glu Ser Pro Glu
65 70 75 80
Ala Pro Leu Ser Asp Pro Val Val Tyr Gly Ala Gln Arg Ala Met Ala
85 90 95
Thr Val Ala Ser Ile Cys Glu Ala Leu Asp Leu Gln Trp Gln Gly Ala
100 105 110
Ser Val Arg Pro Asp Asp Ser Ile Trp Thr Lys Met Gly Gly Thr Tyr
115 120 125
Val Arg Lys Lys His Pro Glu Phe Arg Leu Thr Phe Ser Ser Tyr Asp
130 135 140
Ser Phe Asn Ala Gln Val Gly Arg Phe Leu Ala Ala Val Ile Tyr Ser
145 150 155 160
Arg Ala Gly Leu Glu Pro Lys Phe Val Pro Gly Gly Ala His Val Trp
165 170 175
Arg His Gly Trp Phe Pro Ala Leu Gln Glu Pro Phe Pro Lys Cys Met
180 185 190
His Gly Val Asp Met Val Thr Lys Pro Arg Thr Val Glu Leu Asn Pro
195 200 205
Ser Ser Glu Ala Gly Lys Arg Ala Leu Ala Glu Gln Asn Gly Val Ile
210 215 220
Glu Lys Asn Arg Phe Gly Arg Gln Val Val Val Leu Arg Phe Asp Ala
225 230 235 240
Asn Ala Val Cys Tyr Lys Asp Gln Glu His Ser Gly Phe Pro His Pro
245 250 255
His Ala His Gly Ser Cys Ala Met Val Phe Ser Asp Ala Ala Lys Ala
260 265 270
Val Ser Ala Met Arg His Asp Ile Asp Trp Thr Lys Ala Leu Tyr Pro
275 280 285
Asn Ala Asp Lys Arg Arg Ala Glu Glu Cys Val Leu Ile Ser Thr Asn
290 295 300
Cys Asn Cys Asn Tyr Ala Ser Asp Arg Ala Ile Ser Gly Arg Gln Phe
305 310 315 320
Cys Lys Met Thr Pro Tyr Lys Leu Asn Gly Thr Asp Asp Ile Thr Arg
325 330 335
Asp Met Val Glu Ser Arg Pro Asp Met Lys Ala His Lys Lys Asn Pro
340 345 350
His Thr Met Val Phe Thr Cys Cys Asn Pro Gln Ala Ala Ser Gly Gly
355 360 365
Ala Gly Arg Gly Leu Lys Lys Thr Glu Lys Thr Cys Ala Trp Arg Leu
370 375 380
Ser Ala Met Asp Leu Arg Tyr Ala Tyr Val Phe Ala Thr Glu Leu Phe
385 390 395 400
Thr Ala Val Met Gly Ser Ser Glu Pro Thr His Val Pro Glu Phe Arg
405 410 415
Trp Asn Glu Ser Tyr Ala Phe Lys Thr Glu Val Leu Ala Pro Val Ser
420 425 430
Pro Ile Ala Ser Asp Asp Pro Phe Ala
435 440
<210> 80
<211> 549
<212> PRT
<213> 禽腺病毒A（Fowl adenovirus A）
<400> 80
Met Ala Glu Thr Leu His Pro Glu Thr Ile Ser Ser Asp Glu Asp Val
1 5 10 15
Ala Asp Phe Val Asp Leu Glu Glu Pro Gly Pro Ser Thr Val Ile Lys
20 25 30
Ser Asn Arg Gly Arg Ser Arg Pro Leu Pro Pro Gln Arg Pro Thr Gly
35 40 45
Pro Lys Asp Pro Glu Asn Pro Leu Glu Lys Gln Lys Ser Glu Asp Leu
50 55 60
Pro Arg Ser His Pro Gly Pro Arg Lys Leu Gln Lys Thr Leu Pro Pro
65 70 75 80
Ser Pro Ala Val Val Pro Asp Ser Glu Glu Glu Gly Glu Gln Glu Leu
85 90 95
Phe Glu Thr Arg Asp Pro Val Thr Glu Ala Glu Val Met Glu Arg Thr
100 105 110
Pro Lys Arg Ala His Gly Phe Arg Ser Thr Lys Pro Val Lys Arg Thr
115 120 125
Ala Glu Val Met Met Glu Glu Glu Glu Glu Glu Val Glu Val Val Ala
130 135 140
Pro Gly Arg Gly Ala Thr Arg Lys Lys Val Ser Arg Arg Glu Glu Ser
145 150 155 160
Pro Ser Pro Val Arg Arg Val Thr Arg Arg Arg Glu Thr Val Val Asp
165 170 175
Asp Glu Glu Asn Ala Ser Asp Glu Glu Ser Pro Glu Ala Pro Leu Ser
180 185 190
Asp Pro Val Val Tyr Gly Ala Gln Arg Ala Met Ala Thr Val Ala Ser
195 200 205
Ile Cys Glu Ala Leu Asp Leu Gln Trp Gln Gly Ala Ser Val Arg Pro
210 215 220
Asp Asp Ser Ile Trp Thr Lys Met Gly Gly Thr Tyr Val Arg Lys Lys
225 230 235 240
His Pro Glu Phe Arg Leu Thr Phe Ser Ser Tyr Asp Ser Phe Asn Ala
245 250 255
Gln Val Gly Arg Phe Leu Ala Ala Val Ile Tyr Ser Arg Ala Gly Leu
260 265 270
Glu Pro Lys Phe Val Pro Gly Gly Ala His Val Trp Arg His Gly Trp
275 280 285
Phe Pro Ala Leu Gln Glu Pro Phe Pro Lys Cys Met His Gly Val Asp
290 295 300
Met Val Thr Lys Pro Arg Thr Val Glu Leu Asn Pro Ser Ser Glu Ala
305 310 315 320
Gly Lys Arg Ala Leu Ala Glu Gln Asn Gly Val Ile Glu Lys Asn Arg
325 330 335
Phe Gly Arg Gln Val Val Val Leu Arg Phe Asp Ala Asn Ala Val Cys
340 345 350
Tyr Lys Asp Gln Glu His Ser Gly Phe Pro His Pro His Ala His Gly
355 360 365
Ser Cys Ala Met Val Phe Ser Asp Ala Ala Lys Ala Val Ser Ala Met
370 375 380
Arg His Asp Ile Asp Trp Thr Lys Ala Leu Tyr Pro Asn Ala Asp Lys
385 390 395 400
Arg Arg Ala Glu Glu Cys Val Leu Ile Ser Thr Asn Cys Asn Cys Asn
405 410 415
Tyr Ala Ser Asp Arg Ala Ile Ser Gly Arg Gln Phe Cys Lys Met Thr
420 425 430
Pro Tyr Lys Leu Asn Gly Thr Asp Asp Ile Thr Arg Asp Met Val Glu
435 440 445
Ser Arg Pro Asp Met Lys Ala His Lys Lys Asn Pro His Thr Met Val
450 455 460
Phe Thr Cys Cys Asn Pro Gln Ala Ala Ser Gly Gly Ala Gly Arg Gly
465 470 475 480
Leu Lys Lys Thr Glu Lys Thr Cys Ala Trp Arg Leu Ser Ala Met Asp
485 490 495
Leu Arg Tyr Ala Tyr Val Phe Ala Thr Glu Leu Phe Thr Ala Val Met
500 505 510
Gly Ser Ser Glu Pro Thr His Val Pro Glu Phe Arg Trp Asn Glu Ser
515 520 525
Tyr Ala Phe Lys Thr Glu Val Leu Ala Pro Val Ser Pro Ile Ala Ser
530 535 540
Asp Asp Pro Phe Ala
545
<210> 81
<211> 437
<212> PRT
<213> 禽腺病毒9（Fowl adenovirus 9）
<400> 81
Met Val Lys Asp Ser Ala Pro Lys Thr Thr Ser Lys Lys Met Ala Ser
1 5 10 15
Ser Asp Asp His Glu Asn Ala Glu Pro Ala Met Val Asp Ser Lys Lys
20 25 30
Lys Arg Ser Ala Lys Ser Arg Gly Ala Ala Pro Ser Lys Lys Ala Arg
35 40 45
Lys Glu Thr Gln Glu Arg Glu Glu Val Asp Glu Lys Lys Ser Glu Leu
50 55 60
Asp Val Glu Ser Asp Glu Glu Leu Glu Arg Pro Leu Ser Asp Pro Val
65 70 75 80
Glu Tyr Gly Ala Gln Lys Ala Met Lys Ile Leu Thr Thr Ile Cys Asp
85 90 95
Arg Leu Asp Val Arg Trp Gln Gly Ser Thr Ile Arg Pro Asp Asp Ala
100 105 110
Ile Trp Thr Arg Ile Gly Gly Thr Phe Val Arg Lys Arg His Pro Glu
115 120 125
Phe Arg Leu Thr Phe Ser Ser Phe Asp Ser Phe His Asn Gln Val Gly
130 135 140
Arg Phe Leu Ala Ala Met Val Tyr Gly Met Ala Glu Leu Glu Pro Lys
145 150 155 160
Phe Val Pro Glu Gly Ala His Val Trp Arg His Gly Trp Glu Ala Thr
165 170 175
Thr Asn Thr Thr Pro Lys Cys Leu His Gly Asn Ala Met Phe Leu Lys
180 185 190
Pro Arg Thr Val Glu Leu Asn Pro Thr Ser Glu Ala Gly Lys Arg Ala
195 200 205
Ile Ala Glu Gln Asn Gly Gln Ile Glu Lys Asn Arg Phe Gly Lys Gln
210 215 220
Val Val Val Leu Arg Phe Asp Arg Asn Ala Val Cys Ser Arg Asp Ala
225 230 235 240
Asp His Ser Gly Phe Pro Tyr Pro His Val Ile Gly Ser Cys Gly Met
245 250 255
Ala Phe Ser Asp Ala Ala Lys Ala Val Ser Ala Met Arg His Asp Leu
260 265 270
Glu Trp Thr Lys Ala Leu Tyr Pro Asn Ala Glu Lys Arg Arg Ala Glu
275 280 285
Glu His Ile Leu Ile Ser Thr Asn Cys Asn Cys Asn Tyr Ala Val Gln
290 295 300
Gly Pro Ile Ser Gly Arg Gln Val Cys Arg Met Ile Pro Tyr Lys Leu
305 310 315 320
Ser Gly Thr Asp Asp Ile Ala Ser Asp Thr Ala Arg Ser Arg Pro Asp
325 330 335
Met Lys Ala His Lys Lys Tyr Pro His Thr Met Val Tyr Thr Cys Cys
340 345 350
Asn Pro Gln Ser Pro Ser Gly Thr Asp Gly Pro Thr Ser Arg Ser Gly
355 360 365
Arg Lys Thr Ser Asp Lys Thr Cys Ala Trp Arg Leu Ser Ala Met Asp
370 375 380
Leu Arg His Ala Tyr Val Phe Ala Thr Glu Leu Val Leu Asn Ala Met
385 390 395 400
Gly Val Gln Ala Pro Thr His Val Pro Glu Phe Arg Trp His Glu Arg
405 410 415
Phe Gly Phe Lys Thr Glu Val Ile Ala Pro Val Lys Pro Val Glu Thr
420 425 430
Gly Asp Pro Phe Ala
435
<210> 82
<211> 556
<212> PRT
<213> 禽腺病毒D（Fowl adenovirus D）
<400> 82
Met Ala Glu Ala Ala Asp Arg Asp Leu Trp Val Val Ser Ser Asp Glu
1 5 10 15
Asp Asp Glu Glu Ile Arg Gln Val Phe Gly Ala Arg Glu Lys Thr Pro
20 25 30
Met Pro Asn Ser Asp Asp Ser Glu Ser Asp Trp Ser Gln Pro Lys Thr
35 40 45
Arg Pro Leu Gln Glu Ala Pro Leu Pro Lys Glu Thr Leu Pro Pro Ser
50 55 60
Asp Arg Arg Gly Thr Gly Ser Cys Ser Leu Pro Arg Trp His Lys Ser
65 70 75 80
His Pro Val Lys Val Gln Lys Arg Arg Leu Glu Val Glu Glu Val Phe
85 90 95
Ser Ser Ser Glu Glu Ser Ser Pro Gly Glu Asp Glu Glu Glu Glu Glu
100 105 110
Gly Glu Thr Asp Arg Ser Gly Met Val Lys Asp Ser Ala Pro Lys Thr
115 120 125
Thr Ser Lys Lys Met Ala Ser Ser Asp Asp His Glu Asn Ala Glu Pro
130 135 140
Ala Met Val Asp Ser Lys Lys Lys Arg Ser Ala Lys Ser Arg Gly Ala
145 150 155 160
Ala Pro Ser Lys Lys Ala Arg Lys Glu Thr Gln Glu Arg Glu Glu Val
165 170 175
Asp Glu Lys Lys Ser Glu Leu Asp Val Glu Ser Asp Glu Glu Leu Glu
180 185 190
Arg Pro Leu Ser Asp Pro Val Glu Tyr Gly Ala Gln Lys Ala Met Lys
195 200 205
Ile Leu Thr Thr Ile Cys Asp Arg Leu Asp Val Arg Trp Gln Gly Ser
210 215 220
Thr Ile Arg Pro Asp Asp Ala Ile Trp Thr Arg Ile Gly Gly Thr Phe
225 230 235 240
Val Arg Lys Arg His Pro Glu Phe Arg Leu Thr Phe Ser Ser Phe Asp
245 250 255
Ser Phe His Asn Gln Val Gly Arg Phe Leu Ala Ala Met Val Tyr Gly
260 265 270
Met Ala Glu Leu Glu Pro Lys Phe Val Pro Glu Gly Ala His Val Trp
275 280 285
Arg His Gly Trp Glu Ala Thr Thr Asn Thr Thr Pro Lys Cys Leu His
290 295 300
Gly Asn Ala Met Phe Leu Lys Pro Arg Thr Val Glu Leu Asn Pro Thr
305 310 315 320
Ser Glu Ala Gly Lys Arg Ala Ile Ala Glu Gln Asn Gly Gln Ile Glu
325 330 335
Lys Asn Arg Phe Gly Lys Gln Val Val Val Leu Arg Phe Asp Arg Asn
340 345 350
Ala Val Cys Ser Arg Asp Ala Asp His Ser Gly Phe Pro Tyr Pro His
355 360 365
Val Ile Gly Ser Cys Gly Met Ala Phe Ser Asp Ala Ala Lys Ala Val
370 375 380
Ser Ala Met Arg His Asp Leu Glu Trp Thr Lys Ala Leu Tyr Pro Asn
385 390 395 400
Ala Glu Lys Arg Arg Ala Glu Glu His Ile Leu Ile Ser Thr Asn Cys
405 410 415
Asn Cys Asn Tyr Ala Val Gln Gly Pro Ile Ser Gly Arg Gln Val Cys
420 425 430
Arg Met Ile Pro Tyr Lys Leu Ser Gly Thr Asp Asp Ile Ala Ser Asp
435 440 445
Thr Ala Arg Ser Arg Pro Asp Met Lys Ala His Lys Lys Tyr Pro His
450 455 460
Thr Met Val Tyr Thr Cys Cys Asn Pro Gln Ser Pro Ser Gly Thr Asp
465 470 475 480
Gly Pro Thr Ser Arg Ser Gly Arg Lys Thr Ser Asp Lys Thr Cys Ala
485 490 495
Trp Arg Leu Ser Ala Met Asp Leu Arg His Ala Tyr Val Phe Ala Thr
500 505 510
Glu Leu Val Leu Asn Ala Met Gly Val Gln Ala Pro Thr His Val Pro
515 520 525
Glu Phe Arg Trp His Glu Arg Phe Gly Phe Lys Thr Glu Val Ile Ala
530 535 540
Pro Val Lys Pro Val Glu Thr Gly Asp Pro Phe Ala
545 550 555
<210> 83
<211> 346
<212> PRT
<213> 土耳其腺病毒3（Turkey adenovirus 3）
<400> 83
Met Gln Tyr Ala Thr Gly Leu Gln Ala Leu Phe Ala Cys Gln Ala Glu
1 5 10 15
Ala Asn Ile Leu Pro Thr Ser Asp Tyr Trp Ala Lys Leu Val Glu Thr
20 25 30
Tyr Val Lys Lys Asn Lys Pro Asp Leu Asn Leu Thr Ile Ser Ser Ala
35 40 45
Lys Ser Phe Tyr His Phe Ala Gly Arg Ile Val Ser Ser Phe Val Tyr
50 55 60
Asn Asp Ser Gly Leu Ile Cys Asn Tyr Asn Cys Leu Gly Ala Asn Ile
65 70 75 80
Trp Val His Asn Trp Asp Glu Asp Asn Ile Arg Cys Phe His Gly Thr
85 90 95
Val Met Leu Ser Lys Pro Ile Thr Tyr Ser Leu Ser Pro Gln Ser Glu
100 105 110
Glu Gly Met Arg Ala Leu Thr Ala Gly Glu Gly Arg Leu Glu Lys Glu
115 120 125
Lys Asn Gln Lys Asp Val Ile Lys Leu Thr Asn Tyr Ser Asn Ile Val
130 135 140
Cys Pro Leu Asp Ser Asn Val Gln Trp Pro Thr Ile His Ser Pro Asp
145 150 155 160
Ser Cys Gly Met Asn Phe Gly Asn Lys Glu Lys Ala Lys Ala Ala Phe
165 170 175
Leu His Asn Ile Asp Trp Thr Ser Ala Met Phe Pro Lys Ala Lys Lys
180 185 190
Cys Glu Ile Ser Glu Lys Met Ile Ile Val Thr Lys Cys Phe Cys Asn
195 200 205
Tyr Gly His Glu Asn Ile Gln Leu Gly Arg Gln Ile Cys Lys Met Thr
210 215 220
Ala Phe Glu Ile Pro Gly Ala Asn Asp Ile Asp Pro Glu Ser Cys His
225 230 235 240
Asp Asp Met Leu Leu Ala Thr Ala Lys Tyr Lys His Thr Phe Val Phe
245 250 255
Gln Cys Cys Asn Pro Ile Arg Leu Lys Arg Asn Ala Lys Asp Lys Asp
260 265 270
Asn Gln Thr His Lys His Cys Asp Phe Lys Leu Ser Met Ile Asp Val
275 280 285
Arg Gln Ala Met Lys Ile Ser Lys Asp Ile Tyr Thr Lys Leu Lys Glu
290 295 300
Thr Ile Asp Asp Gly Ser Pro Thr Lys Ile Met Leu Pro Ala Phe Val
305 310 315 320
Phe Asn Pro Lys Lys His Ser Phe Lys Gln Ala Ile Val Ala Gln His
325 330 335
Glu Val Glu Ser Asp Asp Asp Ala Phe Cys
340 345
<210> 84
<211> 380
<212> PRT
<213> 土耳其腺病毒 A（turkey adenovirus A）
<400> 84
Met Ser Ser Asp Gln Arg Ser Leu Val Asp Ser Glu Glu Glu Pro Cys
1 5 10 15
Leu Lys Arg Gln Arg Val Glu Asn Asp Glu Phe Glu Asn Cys His Gln
20 25 30
Lys Ala Met Gln Tyr Ala Thr Gly Leu Gln Ala Leu Phe Ala Cys Gln
35 40 45
Ala Glu Ala Asn Ile Leu Pro Thr Ser Asp Tyr Trp Ala Lys Leu Val
50 55 60
Glu Thr Tyr Val Lys Lys Asn Lys Pro Asp Leu Asn Leu Thr Ile Ser
65 70 75 80
Ser Ala Lys Ser Phe Tyr His Phe Ala Gly Arg Ile Val Ser Ser Phe
85 90 95
Val Tyr Asn Asp Ser Gly Leu Ile Cys Asn Tyr Asn Cys Leu Gly Ala
100 105 110
Asn Ile Trp Val His Asn Trp Asp Glu Asp Asn Ile Arg Cys Phe His
115 120 125
Gly Thr Val Met Leu Ser Lys Pro Ile Thr Tyr Ser Leu Ser Pro Gln
130 135 140
Ser Glu Glu Gly Met Arg Ala Leu Thr Ala Gly Glu Gly Arg Leu Glu
145 150 155 160
Lys Glu Lys Asn Gln Lys Asp Val Ile Lys Leu Thr Asn Tyr Ser Asn
165 170 175
Ile Val Cys Pro Leu Asp Ser Asn Val Gln Trp Pro Thr Ile His Ser
180 185 190
Pro Asp Ser Cys Gly Met Asn Phe Gly Asn Lys Glu Lys Ala Lys Ala
195 200 205
Ala Phe Leu His Asn Ile Asp Trp Thr Ser Ala Met Phe Pro Lys Ala
210 215 220
Lys Lys Cys Glu Ile Ser Glu Lys Met Ile Ile Val Thr Lys Cys Phe
225 230 235 240
Cys Asn Tyr Gly His Glu Asn Ile Gln Leu Gly Arg Gln Ile Cys Lys
245 250 255
Met Thr Ala Phe Glu Ile Pro Gly Ala Asn Asp Ile Asp Pro Glu Ser
260 265 270
Cys His Asp Asp Met Leu Leu Ala Thr Ala Lys Tyr Lys His Thr Phe
275 280 285
Val Phe Gln Cys Cys Asn Pro Ile Arg Leu Lys Arg Asn Ala Lys Asp
290 295 300
Lys Asp Asn Gln Thr His Lys His Cys Asp Phe Lys Leu Ser Met Ile
305 310 315 320
Asp Val Arg Gln Ala Met Lys Ile Ser Lys Asp Ile Tyr Thr Lys Leu
325 330 335
Lys Glu Thr Ile Asp Asp Gly Ser Pro Thr Lys Ile Met Leu Pro Ala
340 345 350
Phe Val Phe Asn Pro Lys Lys His Ser Phe Lys Gln Ala Ile Val Ala
355 360 365
Gln His Glu Val Glu Ser Asp Asp Asp Ala Phe Cys
370 375 380
<210> 85
<211> 378
<212> PRT
<213> 蛙腺病毒1（frog adenovirus 1）
<400> 85
Met Ser Glu Lys Arg Pro Ala Val Asp His Glu Glu Glu Pro Gln Ala
1 5 10 15
Lys Lys Gln Leu Glu Asp Asn Phe Ile Leu Cys Glu Glu Ala Ala Lys
20 25 30
Asn Tyr Ala Ser Ala Leu Ala Gly Met Ile Gly Cys Pro Thr Asp Val
35 40 45
Asn Leu Leu Pro Thr Ser Glu Phe Trp Ala Arg Ile Ser Glu Asn Tyr
50 55 60
Ile Lys Lys Phe Arg Thr Asp Phe Phe Leu Thr Asn Ser Thr Leu Lys
65 70 75 80
Ser Phe Thr His Tyr Leu Gly Arg Leu Leu Ala Ser Tyr Val His Ala
85 90 95
Thr Ala Gly Phe Glu Pro Lys Phe Asn Ile Leu Gly Ser Glu Ile Trp
100 105 110
Val His Asn Trp Glu Glu Gly Glu Asn Leu Glu Leu Arg Cys Phe His
115 120 125
Gly Glu Lys Met Met Lys Lys Thr Ile Ser Tyr Glu Leu Val Pro Thr
130 135 140
Thr Val Glu Ala Val Lys Ala Leu Ala Ser Gly Glu Gly Lys Leu Glu
145 150 155 160
Lys Gly Lys Gly Asn Lys Asp Val Val Lys Ile Val Asn Asn Lys Asn
165 170 175
Tyr Val Cys Pro Lys Asp Ile Asp Tyr Asn Gly Phe Pro Ala Ile His
180 185 190
Ala Ser Thr Ser Cys Gly Leu Asn Phe Ala Asn Gly Glu Lys Ala Lys
195 200 205
Ser Ala Phe Leu His Tyr Ala Asp Trp Thr Gln Ala Met Tyr Pro Lys
210 215 220
Ala Asn Arg Ala Ser Ile Arg Glu Lys Met Ile Ile Val Thr Arg Cys
225 230 235 240
Leu Cys Asn Phe Gly His Asp Asn Val Gln Val Gly Arg Gln Ile Ser
245 250 255
Lys Leu Thr Pro Phe Glu Ile Pro Gly Ser Asn Asp Leu Thr Gln Asp
260 265 270
Gln Met Asp Glu Cys Gly Met Met Lys Ala Thr Gly Gln His Gln Ala
275 280 285
Thr Ile Val Phe Leu Cys Cys Asn Pro Val Asn Phe Arg Ala Lys Val
290 295 300
Thr Ile Ala Lys Asn Cys Asp Phe Lys Leu Ser Met Ile Asp Leu Arg
305 310 315 320
Leu Ala Ile Lys Met Ser Lys Glu Ile Trp Ala Lys Leu Asn Asp Gln
325 330 335
Leu Glu Gly Lys Leu Ala Pro Ala Lys Leu Ala Phe Pro Val Phe Lys
340 345 350
Phe Asp Pro Lys Arg His Cys Tyr Lys Ser Ala Val Val Cys Ala Gln
355 360 365
Glu Val Glu Glu Asp Glu Asp Val Phe Cys
370 375
<210> 86
<211> 461
<212> PRT
<213> 小鼠腺病毒3（Murine adenovirus 3）
<400> 86
Met Ser Cys Ser Arg Pro Leu Pro Pro His Arg Val Gly Gln Gln Gln
1 5 10 15
Val Phe Gly Ser Arg Lys Gly Gly Met Lys Arg Leu Pro Pro Thr Glu
20 25 30
Ala Gly Glu Ser Ser Lys Arg Ser Arg Thr Val Ala Glu Ala Val Thr
35 40 45
Ser Thr Gly Gly Ser Gly Ser Thr Gly Gly Ile Gly Asp Arg Pro Leu
50 55 60
Gly Ala Val Cys Asp Ser Pro Thr Asn Pro Glu Pro Gln Glu Glu Val
65 70 75 80
Leu Pro Arg Arg Arg Phe Glu Ser Ser Asp Glu Glu Glu Asp Val Phe
85 90 95
Asp Asp Gly Thr Val Thr Glu Glu Glu Ala Cys Trp Gln Thr Ala Arg
100 105 110
Glu Phe Leu His Lys Met Cys Leu Pro Leu Lys Val Asp Gly Lys Gln
115 120 125
Cys Thr Phe Leu Pro Asn Ala Gln Thr Ala Glu Leu Phe Arg Lys Leu
130 135 140
Cys His Ser Trp Leu Leu Gln Gln Lys Met Val Pro Ser Leu Thr Phe
145 150 155 160
Thr Thr Leu Arg Ser Phe Thr Met Gln Met Gly Arg Phe Val Leu Ala
165 170 175
Leu Leu Leu Gln Ala Ser Gly Leu Ser Pro Thr Glu Ala Ala Ala His
180 185 190
Ser Ile Ala Asn Val Ser Gly Val Ala Ala Trp Lys His Ala Ser Asp
195 200 205
Val Thr Leu His Cys Leu His Gly Ala Val Met Ile Ala Lys Asp His
210 215 220
His Val Asp Leu Asp Val Ser Ser Glu Gly Gly Gln Arg Ala Leu Lys
225 230 235 240
Glu Gln Gly Pro Asn Ala Val Val Thr Thr Asn Arg Trp Gly Arg Ser
245 250 255
Val Val Arg Val Lys Tyr Asp Ala Phe Val Cys Pro Met Asp Ala Gly
260 265 270
Val Pro Phe Asn Gln Pro Ser Asn Lys Ser Cys Gly Phe Cys Phe Thr
275 280 285
Asp Gly Lys Lys Ala Leu Lys Gly Phe Lys Gln Ile Val Ala Phe Gln
290 295 300
Ala Ala Leu Tyr Pro Gln Ala Ala Gly Gly Gly Glu Trp Met Leu Leu
305 310 315 320
Cys Leu Arg Cys Glu Cys Asn Phe Gly Val Ala Gln Pro Ile Leu Gly
325 330 335
Arg Gln Thr Cys Arg Leu Thr Pro Tyr Gln Leu Ser Leu Ala Glu Gly
340 345 350
Leu Asp Gly Gly Asn Met Asp Ala Val Ala Lys Ala Ser Val Glu Asn
355 360 365
Pro Val Val Leu Val Ala Gln Cys Cys Asn Val Thr Phe Ser Lys Ala
370 375 380
Gly Lys Ala Gly Gly Ala Ala Ala Gly Lys Thr Cys Glu Trp Lys Ile
385 390 395 400
Ser Ser Val Asp Leu Val Thr Ala Ala Gln Leu Ala Lys Lys Met Ile
405 410 415
His Lys Met Leu Asp Leu Pro Pro Ser Leu Phe Val Pro Glu Phe Lys
420 425 430
Trp Asp Pro Val Phe Ser Phe Arg Ser Thr Val Leu Pro Gln Gly Val
435 440 445
Gly Asp Ser Asp Leu Gln Leu Phe Thr Thr Gly Gly Met
450 455 460
<210> 87
<211> 461
<212> PRT
<213> 小鼠腺病毒A（Murine adenovirus A）
<400> 87
Met Ser Cys Ser Arg Pro Val Pro Pro Gln Arg Thr Pro Gln Gln Gln
1 5 10 15
Val Tyr Glu Thr Lys Arg Gly Gly Val Lys Arg Ser Ala Val Gly Glu
20 25 30
Ala Ser Thr Ala His Cys Gly Lys Lys Ser Arg Ala Ala Leu Gly Pro
35 40 45
Arg Ser Ser Pro Leu Ala Pro Ala Val Ser Gly Lys Phe Ala Asn Val
50 55 60
Ser Gly Gly Asp Arg Gly Ser Glu Asp Val Asn Met Glu Pro Glu Pro
65 70 75 80
Gln Thr Glu Val Pro Pro Arg Phe Glu Ser Ser Asp Glu Asp Asp Val
85 90 95
Val Phe Thr Glu Ala Gly Val Ala Glu Glu Glu Glu Ala Cys Trp Gln
100 105 110
Thr Ala Arg Glu Leu Leu His Lys Met Cys Leu Val Leu Lys Val Asp
115 120 125
Gly Lys Gln Cys Thr Phe Leu Pro Asn Ala Gln Thr Ala Glu Leu Phe
130 135 140
Arg Lys Leu Ser His Ser Trp Leu Leu Gln Gln Lys Leu Val Pro Ser
145 150 155 160
Leu Thr Phe Ser Thr Leu Arg Ser Phe Thr Met Gln Met Gly Arg Phe
165 170 175
Val Phe Ala Met Leu Leu Gln Ala Ala Gly Ile Ser Pro Val Asp Phe
180 185 190
Ala Ala His Thr Leu Gly Asn Val Thr Gly Val Ala Ala Trp Lys His
195 200 205
Asn Cys Ser Thr Thr Leu His Cys Leu His Gly Thr Ala Met Ser Pro
210 215 220
Lys Asp His Gln Val Glu Leu Asp Val Thr Thr Glu Gly Gly Gln Arg
225 230 235 240
Ala Leu Lys Glu Gln Gly Ser Ala Ala Cys Val Gln Thr Asn Arg Trp
245 250 255
Gly Arg Ser Val Val Arg Val Thr Tyr Asp Ala Val Val Cys Ala Met
260 265 270
Asp Ala Ser Val Ala Phe Asn Gln Pro Thr Asn Lys Ser Cys Gly Phe
275 280 285
Cys Phe Thr Asp Ala Lys Lys Ala Leu Lys Gly Phe Lys Gln Ala Ile
290 295 300
Ala Phe Gln Gln Ala Leu Tyr Pro Gln Ala Pro Gly Val Gly Glu Arg
305 310 315 320
Met Leu Leu Cys Leu Arg Cys Glu Cys Asn Phe Gly Leu Ala Gln Pro
325 330 335
Ile Leu Gly Arg Gln Thr Cys Arg Val Thr Pro Tyr Ala Leu Ser Leu
340 345 350
Ala Glu Gly Leu Asp Ala Thr Ala Leu Asp Pro Val Ala Arg Ala Ser
355 360 365
Val Glu Asn Pro Val Val Leu Val Tyr Gln Cys Cys Asn Val Thr Phe
370 375 380
Gly Lys Ala Gly Lys Gly Thr Val Gly Lys Ser Cys Glu Trp Lys Ile
385 390 395 400
Ser Ser Val Asp Val Val Thr Ala Ala Gln Leu Ala Lys Lys Met Ile
405 410 415
Gln Lys Leu Leu Asp Gln Pro Pro Ser Leu Phe Val Pro Glu Phe Lys
420 425 430
Trp Asp Pro Thr Leu Cys Phe His Ser Thr Val Leu Pro Gln Gly Ala
435 440 445
Gly Asp Gly Asp Val Gln Leu Phe Val Thr Ala Lys Val
450 455 460
<210> 88
<211> 513
<212> PRT
<213> 猴腺病毒22（Simian adenovirus 22）
<400> 88
Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg
1 5 10 15
Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu
20 25 30
Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg
35 40 45
Val Val Ser Asp Asp Gly Gln Glu Glu Glu Ile Val Val Val Ser Glu
50 55 60
Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Pro Leu Pro Pro Lys
65 70 75 80
Lys Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln
85 90 95
Asp Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly
100 105 110
Phe Ser Phe Pro Pro Val Arg Ile Thr Glu Lys Asp Gly Lys Arg Val
115 120 125
Phe Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr
130 135 140
Lys Met Thr Thr Ala Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser
145 150 155 160
Ala Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr
165 170 175
Arg Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln
180 185 190
Gly Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His
195 200 205
Arg Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Thr Met
210 215 220
Met Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala
225 230 235 240
His Lys Asn Trp Glu Cys Thr Gly Cys Ala Leu Trp Leu His Gly Cys
245 250 255
Thr Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile
260 265 270
Gln Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln
275 280 285
Arg Ala Leu Lys Glu Asn Pro Asp Arg Ala Lys Ile Thr Gln Asn Arg
290 295 300
Trp Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys
305 310 315 320
Val His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys
325 330 335
Gly Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln
340 345 350
Leu Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln
355 360 365
Ala Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro
370 375 380
Gly Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe
385 390 395 400
Gly Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala
405 410 415
Thr Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys
420 425 430
Cys Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn
435 440 445
Cys Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu
450 455 460
Thr Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys
465 470 475 480
Leu Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn
485 490 495
Val Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp
500 505 510
Phe
<210> 89
<211> 512
<212> PRT
<213> 猴腺病毒24（Simian adenovirus 24）
<400> 89
Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg
1 5 10 15
Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu
20 25 30
Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg
35 40 45
Val Val Ser Asp Asp Gly Gln Gly Glu Glu Ile Val Val Val Ser Glu
50 55 60
Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Pro Leu Pro Pro Lys
65 70 75 80
Lys Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln
85 90 95
Asp Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly
100 105 110
Phe Ser Phe Pro Pro Val Arg Ile Thr Glu Lys Asp Gly Lys Arg Val
115 120 125
Phe Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr
130 135 140
Lys Met Thr Thr Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser Ala
145 150 155 160
Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr Arg
165 170 175
Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln Gly
180 185 190
Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His Arg
195 200 205
Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Thr Met Met
210 215 220
Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala His
225 230 235 240
Lys Asn Trp Glu Ser Thr Gly Cys Ala Leu Trp Leu His Gly Cys Thr
245 250 255
Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile Gln
260 265 270
Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln Arg
275 280 285
Ala Leu Lys Glu Asn Pro Asp Arg Ala Lys Ile Thr Gln Asn Arg Trp
290 295 300
Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys Val
305 310 315 320
His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys Gly
325 330 335
Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Leu
340 345 350
Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln Ala
355 360 365
Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro Gly
370 375 380
Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe Gly
385 390 395 400
Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala Thr
405 410 415
Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys Cys
420 425 430
Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn Cys
435 440 445
Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu Thr
450 455 460
Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys Leu
465 470 475 480
Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn Val
485 490 495
Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp Phe
500 505 510
<210> 90
<211> 512
<212> PRT
<213> 猴腺病毒23（Simian adenovirus 23）
<400> 90
Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg
1 5 10 15
Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu
20 25 30
Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg
35 40 45
Val Val Ser Asp Asp Gly Gln Glu Glu Glu Ile Val Val Val Asn Glu
50 55 60
Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Leu Pro Pro Lys Lys
65 70 75 80
Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln Asp
85 90 95
Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly Phe
100 105 110
Ser Phe Pro Pro Val Arg Ile Ile Glu Lys Asp Gly Lys Arg Val Phe
115 120 125
Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr Lys
130 135 140
Met Thr Met Ala Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser Ala
145 150 155 160
Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr Arg
165 170 175
Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln Gly
180 185 190
Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His Arg
195 200 205
Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Ala Met Met
210 215 220
Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala His
225 230 235 240
Lys Asn Trp Glu Cys Thr Gly Cys Ala Leu Trp Leu His Gly Cys Thr
245 250 255
Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile Gln
260 265 270
Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln Arg
275 280 285
Ala Leu Lys Glu Asn Pro Asn Arg Ala Lys Ile Thr Gln Asn Arg Trp
290 295 300
Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys Val
305 310 315 320
His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys Gly
325 330 335
Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Leu
340 345 350
Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln Ala
355 360 365
Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro Gly
370 375 380
Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe Gly
385 390 395 400
Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala Thr
405 410 415
Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys Cys
420 425 430
Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn Cys
435 440 445
Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu Thr
450 455 460
Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys Leu
465 470 475 480
Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn Val
485 490 495
Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp Phe
500 505 510
<210> 91
<211> 462
<212> PRT
<213> 猴腺病毒1（Simian adenovirus 1）
<400> 91
Met Ala Asn Arg Gln Asn Gln Ala Gly Ser Ser Ile Thr Pro Tyr Leu
1 5 10 15
Arg Glu Met Ser Pro Glu Arg Glu Gln Glu Ala Pro Gln Leu Pro Pro
20 25 30
Lys Lys Lys Ala Arg Lys Ala Thr Pro Ala Pro Pro Pro Ser Pro Glu
35 40 45
Ile Val Ser Asp Ser Glu Gly Glu Gly Thr Val Val Glu Val Gly Phe
50 55 60
Ser Tyr Pro Pro Val Arg Arg Val Arg Arg Ala Asp Gly Ser Val Glu
65 70 75 80
Phe Gln Arg Met Thr Met Lys Asp Val Gly Ala Gly Glu Gly Pro Ser
85 90 95
Thr Ala Val Leu Val Lys Asn Pro Asp Ser Lys Pro Leu Val Thr Ala
100 105 110
Trp Glu Lys Gly Met Glu Thr Met Met Met Leu Met Glu Lys Phe His
115 120 125
Val Asp Asn Asp Ser Arg Ala Ala Phe Lys Phe Leu Pro Asp Gln Gly
130 135 140
Ala Val Tyr Arg Lys Ile Cys Gln Thr Trp Leu Asn Glu Glu His Arg
145 150 155 160
Gly Leu Pro Leu Thr Phe Thr Asn Gln Lys Thr Phe Thr Glu Leu Met
165 170 175
Gly Arg Phe Leu Met Ala Tyr Met Glu Ala Tyr Ala Gly Val Lys His
180 185 190
Lys Ser Trp Glu Pro Thr Gly Cys Ala Val Trp Glu His Arg Ser Thr
195 200 205
Gln Gln Glu Gly Val Leu Phe Cys Phe His Gly Val Glu Met Val Cys
210 215 220
Lys Glu His Val Leu Glu Met Asp Val Thr Ser Glu Asn Gly Gln Arg
225 230 235 240
Ala Leu Lys Glu His Pro Thr Arg Ala Lys Val Val Gln Asn Arg Trp
245 250 255
Gly Arg Asn Val Val Gln Leu Lys Asn Glu Asp Ala Arg Cys Cys Ala
260 265 270
Glu Asp Val Asn Cys Gly His Asn Val Phe Ser Ser Lys Ser Cys Gly
275 280 285
Leu Phe Tyr Thr Glu Gly Gly Lys Ala Gln Met Ala Phe Arg Gln Met
290 295 300
Glu Glu Phe Leu Ala Ala Ser Tyr Pro Ile Met Gln Arg Gly Gln Arg
305 310 315 320
Arg Ile Leu Ile Pro Leu Arg Cys Asp Cys Leu Asn Lys Arg Asp Leu
325 330 335
Val Pro Gln Ile Gly Arg Gln Met Cys Lys Leu Thr Pro Phe Ala Leu
340 345 350
Ser Asn Ala Glu Asp Leu Asp Ala Ser Glu Val Thr Asp Pro Thr Ala
355 360 365
Leu Ala Ser Ile His Asn Pro Gly Val Leu Val Phe Gln Cys Ala Asn
370 375 380
Pro Val Phe Arg Asn Ser Arg Gly Ser Ser Gly Pro Asn Cys Asp Phe
385 390 395 400
Lys Ile Ser Ala Pro Asp Val Met Gly Ala Leu Gln Leu Val Arg Gln
405 410 415
Phe Trp Lys Gln Asn Leu Glu Asp Val Pro Leu Pro Arg Leu Val Ile
420 425 430
Pro Glu Phe Arg Trp Ser Ala Arg Phe Gln Tyr Arg Asn Val Ser Leu
435 440 445
Pro Ser Gly His Glu Asp Pro Ser Leu Glu Pro Phe Asp Phe
450 455 460
<210> 92
<211> 462
<212> PRT
<213> 猴腺病毒7（Simian adenovirus 7）
<400> 92
Met Ala Asn Arg Gln Asn Gln Pro Gly Ser Ser Ile Thr Pro Tyr Leu
1 5 10 15
Arg Glu Met Ser Pro Glu Arg Glu Gln Glu Val Pro Pro Leu Pro Pro
20 25 30
Lys Lys Lys Ala Arg Lys Ser Ala Pro Val Pro Pro Pro Ser Pro Glu
35 40 45
Ile Val Ser Asp Ser Glu Gly Glu Ser Thr Val Met Glu Val Gly Phe
50 55 60
Ser Tyr Pro Pro Met Arg Arg Val Arg Arg Ala Asp Gly Thr Val Glu
65 70 75 80
Phe Gln Lys Met Ser Met Lys Asp Val Gly Ala Gly Glu Gly Pro Ser
85 90 95
Thr Ala Val Leu Val Lys Asn Pro Glu Ser Ala Pro Leu Val Thr Ala
100 105 110
Trp Glu Lys Gly Met Glu Val Met Thr Met Leu Met Glu Lys Phe His
115 120 125
Val Asp Asn Glu Ser Arg Thr Thr Phe Lys Phe Leu Pro Asp Gln Gly
130 135 140
Ala Val Tyr Arg Lys Ile Cys Gln Thr Trp Leu Asn Glu Glu His Arg
145 150 155 160
Gly Leu Pro Leu Thr Phe Thr Asn Gln Lys Thr Phe Thr Glu Leu Met
165 170 175
Gly Arg Phe Leu Met Ala Tyr Met Glu Ala Tyr Ala Gly Val Lys His
180 185 190
Lys Ser Trp Glu Ser Thr Gly Cys Ala Val Trp Glu His Arg Asn Thr
195 200 205
Gln Gln Glu Gly Ile Leu Phe Cys Phe His Gly Val Glu Met Val Cys
210 215 220
Lys Glu His Val Val Glu Met Asp Val Thr Ser Glu Asn Gly Gln Arg
225 230 235 240
Ala Leu Lys Glu His Pro Thr Lys Ala Lys Val Val Gln Asn Arg Trp
245 250 255
Gly Arg Asn Val Val Gln Leu Lys Asn Glu Asp Ala Arg Cys Cys Ala
260 265 270
Glu Asp Ile Asn Cys Gly Asn Asn Val Phe Ser Ser Lys Ser Cys Gly
275 280 285
Leu Phe Phe Thr Glu Gly Val Lys Ala Gln Met Ala Phe Arg Gln Ile
290 295 300
Glu Glu Phe Leu Ala Ala Ser Tyr Pro Ile Met Gln Arg Gly Gln Arg
305 310 315 320
Arg Ile Leu Ile Pro Leu Arg Cys Asp Cys Leu Asn Lys Arg Asp Leu
325 330 335
Val Pro Gln Ile Gly Arg Gln Met Cys Lys Leu Thr Pro Phe Ala Leu
340 345 350
Ser Asn Ala Glu Asp Leu Asp Ala Ser Glu Val Thr Asp Pro Thr Ala
355 360 365
Leu Ala Ser Ile His Asn Pro Ser Val Leu Val Phe Gln Cys Ala Asn
370 375 380
Pro Val Phe Arg Asn Ser Arg Gly Gly Ser Gly Pro Asn Cys Asp Phe
385 390 395 400
Lys Ile Ser Ala Pro Asp Val Met Gly Ala Leu Gln Leu Val Arg Gln
405 410 415
Phe Trp Lys Gln Asn Met Glu Asp Val Ala Leu Pro Arg Leu Val Ile
420 425 430
Pro Glu Phe Arg Trp Ser Ala Arg Phe Gln Tyr Arg Asn Val Ser Leu
435 440 445
Pro Ser Gly His Glu Asp Pro Ser Leu Glu Pro Phe Asp Phe
450 455 460
<210> 93
<211> 493
<212> PRT
<213> 猕猴腺病毒1（Cynomolgus adenovirus 1）
<400> 93
Met Ala Asp Arg Gln Asp Gln Arg Glu Arg Thr Pro Glu Arg Pro Arg
1 5 10 15
Pro Ala Thr Pro Ser Ile Arg Arg Tyr Leu Gln Ala Ser Pro Glu Arg
20 25 30
Ala Pro Thr Pro Ala Pro Pro Gln Lys Lys Ala Arg Lys Ser Leu Leu
35 40 45
Ala Pro Leu Ala Glu Met Pro Pro Ser Pro Glu Ile Val Leu Asp Ser
50 55 60
Asp Asp Glu Glu Asn Leu Ala Ile Ala Glu Glu Ser Gln Ala Gly Val
65 70 75 80
Val Thr Met Val Gly Phe Ser Tyr Pro Pro Val Gln Ile Thr Arg Asn
85 90 95
Pro Asp Gly Ser Arg Ala Phe Lys Lys Leu Pro Pro Pro Pro Leu Pro
100 105 110
Ala Asp Ala Glu Lys Asp Glu Glu Gln Pro Ser Thr Ser Arg Ala Ala
115 120 125
Val Val Val Arg Asn Pro Leu Ser Lys Pro Val Val Ser Ala Trp Glu
130 135 140
Lys Gly Met Ala Val Met His Val Leu Met Asp Lys Tyr Lys Ile Glu
145 150 155 160
Asp Arg Ala Ala Phe His Phe Met Pro Gln Ser Phe Glu Val Tyr Arg
165 170 175
Lys Ile Cys His Thr Trp Leu Gln Glu Asp Leu Lys Tyr Cys Pro Leu
180 185 190
Thr Phe Ser Thr Gln Lys Thr Phe Ser Ala Met Met Gly Arg Phe Leu
195 200 205
Asn Lys Tyr Val Leu Leu His Ala Gly Ile Glu Asn Pro Leu Tyr Lys
210 215 220
Ser Trp Glu Pro Thr Gly Cys Val Val Trp Glu His Arg Cys Thr Glu
225 230 235 240
Gln Glu Gly Gln Leu Met Cys Leu His Gly Leu Pro Met Ile Ala Lys
245 250 255
Asp His Val Val Glu Met Asp Val Ser Ser Glu Ala Gly Gln Arg Ala
260 265 270
Leu Lys Glu Thr Pro Gln Leu Ala Lys Val Val Gln Asn Arg Trp Gly
275 280 285
Arg Asn Val Val Gln Leu Arg His Asp Asn Ala Arg Cys Cys Met Phe
290 295 300
Asp Ala Gln Cys Gly Thr Asn Val Phe Ser Gly Lys Ser Cys Gly Met
305 310 315 320
Phe Tyr Ser Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Ile Glu
325 330 335
Ala Tyr Met Gln Ala Ala Tyr Pro His Met Gln Arg Gly Gln Lys His
340 345 350
Leu Leu Met Pro Leu Arg Cys Asp Cys Asn Tyr Leu Gly Asp Ala Val
355 360 365
Pro Arg Ala Gly Arg Gln Val Cys Lys Ile Thr Pro Phe Ala Leu Pro
370 375 380
Gly Ala Glu Asp Met Lys His Asp Glu Val Thr Asp Pro Val Ala Leu
385 390 395 400
Ala Ser Leu Asn His Pro Ser Leu Leu Val Phe Gln Cys Ala Asn Pro
405 410 415
Ala Tyr Arg Asn Thr Arg Ala Thr Asn Gln Val Asn Cys Asp Phe Lys
420 425 430
Ile Ser Ala Thr Asp Val Leu Leu Ala Leu Gln Leu Val Arg Asn Leu
435 440 445
Trp His Asp His Phe Val Glu Ala Gly Leu Pro Lys Met Val Leu Pro
450 455 460
Glu Phe Lys Trp Gln Pro Arg Tyr Gln Tyr Lys Asn Leu Thr Leu Pro
465 470 475 480
Thr Ala His Leu Asp Tyr Gln Leu Asn Pro Phe Glu Phe
485 490
<210> 94
<211> 472
<212> PRT
<213> 蝙蝠腺病毒 TJM（Bat adenovirus TJM）
<400> 94
Met Ser His Val Ile Ser Ser Ser Ser Asp Glu Asp Ile Pro Val Pro
1 5 10 15
Val Arg Lys Arg Gln Arg Lys Ser Lys Glu Asp Ala Lys Ala Arg Ala
20 25 30
Lys Glu Ser Pro Arg Pro Glu Lys Glu Asp Ser Ser Leu Val Gly His
35 40 45
Gly Tyr Ala Leu Glu Met Thr Arg Arg Ala Asn Ala Ile Leu Glu Ala
50 55 60
Gln Gly Lys Pro Gly Gly Phe Tyr Ile Gln Thr Phe Cys Gly Gln Arg
65 70 75 80
Val Glu Lys Asp Ala Asn Gly Glu Ile Gln Phe Ile Lys Gln Asp Pro
85 90 95
Pro Ser Ala Pro Pro Leu Pro Met Asp Pro Ala Leu Lys Ala Gln Leu
100 105 110
Met Glu Pro Leu Ile Gln Ala Ala Val Asp Met Arg Pro Thr Lys Ala
115 120 125
Asn Glu His Gln Trp Gln Leu Gly Met Glu Met Ala Leu Lys Ile Leu
130 135 140
Thr Ala Tyr Gln Val Asp His Lys Glu Leu Thr Leu Leu Pro Asp Ser
145 150 155 160
Gly Thr Leu Glu Cys Phe Lys Lys Ala Ala Gln Ala Tyr Leu Val Asn
165 170 175
Thr Lys Thr Val Val Thr Tyr Asn Phe Thr Thr Gln Lys Ser Phe Gln
180 185 190
His Met Val Gly Arg Ile Leu Leu Asp Phe Val Ile Lys Ala Ala Gly
195 200 205
Val Ala Pro Gly Leu Asn Pro Ser Gly Cys Val Val Trp Gln His Gly
210 215 220
Cys Gln Arg Gln Leu His Cys Leu His Gly Ser Pro Met Ile Gln Lys
225 230 235 240
Glu Gln Leu Ile Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Val
245 250 255
Leu Lys Glu Asn Pro Glu Lys Thr Lys Ile Val Thr Asn Arg Trp Gly
260 265 270
Arg Asn Val Val Gln Met Lys Asn Glu Asp Ala Tyr Cys Cys Phe Met
275 280 285
Asp Val Asn Ile Ser Gly Gly Asn Phe Ser Ser Ser Ser Cys Gly Met
290 295 300
Ser Tyr Thr Asp Gly Pro Lys Ala Leu Met Ala Phe Gln Gln Ile Met
305 310 315 320
Ala Phe Gln Arg Ala Cys Tyr Pro Gln Met Ser Thr Ala Glu Ser His
325 330 335
Leu Leu Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Asn Ser Leu Pro
340 345 350
Met Leu Gly Arg Gln Thr Cys Lys Met Thr Pro Tyr Ala Leu Ser Ser
355 360 365
Thr Ala Asp Ile Asp Arg Ser Leu Val Gln Asp Ala Lys Met Leu Ala
370 375 380
Thr Leu Asp His Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val
385 390 395 400
Tyr Arg Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile
405 410 415
Ser Thr Val Asp Met Val Ala Cys Val Gln Ile Ala Lys Lys Ile Trp
420 425 430
Ser Thr Cys Ile Gly Thr Pro Pro Pro Leu Lys Phe Pro Glu Phe Lys
435 440 445
Trp Ser Gln Glu Tyr Lys Tyr Gln Thr Thr Ile Leu Pro Gln Gly Gln
450 455 460
Glu Asp Asn Asp Val Ser Leu Phe
465 470
<210> 95
<211> 454
<212> PRT
<213> 犬腺病毒1（Canine adenovirus 1）
<400> 95
Met Ser His Lys Lys Val Val Ala Ile Ser Glu Ser Ser Ser Asp Glu
1 5 10 15
Glu Val Pro Val Ala Pro Pro Thr Ala Pro Pro Lys Lys Arg Gln Arg
20 25 30
Lys Ala Val Glu Glu Pro Arg Gly His Gln Ala Met Val Glu Ile Ala
35 40 45
Arg Gln Ala Thr Ala Ala Leu Lys Ala Arg Gly Asp Pro Gly Ser Ile
50 55 60
Ile Val Gln Thr Phe Cys Asp Gln Thr Val Asp Val Asp Lys Glu Gly
65 70 75 80
Asn Val Ile Phe Thr Pro Ala Lys Gln Lys Ser Ile Cys Asn Lys Ser
85 90 95
Gly Ser Pro Leu Ala Ser Val Ala Ser Lys Ile Phe Lys Ala Ser Glu
100 105 110
His Lys Trp Gln Ser Ala Met Glu Phe Ala Leu Lys Val Leu Asn Ala
115 120 125
Tyr Gln Val Asp His Ser Lys Leu Thr Leu Leu Pro Asp Glu Gly Thr
130 135 140
Leu Glu Cys Phe Lys Lys Ala Val Gln Ala Tyr Ile Thr Thr Ser Lys
145 150 155 160
Met His Val Thr Tyr Thr Phe Thr Asn Gln Lys Thr Phe Leu His Val
165 170 175
Ala Gly Arg Leu Leu Leu Asp Phe Val Ile Lys Ala Ala Glu Leu Ala
180 185 190
Pro Gly Val Asn Pro Ser Gly Cys Val Val Trp Gln His Gly Cys Gln
195 200 205
Ser Ser Leu Met Cys Leu His Gly Ser Pro Met Ile Gln Lys Glu Gln
210 215 220
Leu Val Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Ala Leu Lys
225 230 235 240
Glu Asn Pro Glu Lys Thr Lys Ile Val Ser Asn Arg Trp Gly Arg Asn
245 250 255
Val Val Gln Phe Lys Asn Glu Asp Ala Phe Cys Cys Ser Met Asp Val
260 265 270
Asn Met Ser Gly Gly Asn Phe Ser Gly Ala Ser Cys Gly Met Phe Tyr
275 280 285
Thr Asp Gly Pro Lys Ala Ile Met Ala Phe Gln Gln Ile Met Ala Phe
290 295 300
Leu Lys Ala Cys Tyr Pro Ser Met Pro Asn Ala Glu Ser His Leu Leu
305 310 315 320
Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Ser Ser Leu Pro Leu Leu
325 330 335
Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ser Leu Ala Ser Ala Asn
340 345 350
His Ile Asp Lys Ser Glu Val Asp Asp Gln Lys Met Leu Ala Thr Leu
355 360 365
Asn Asn Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg
370 375 380
Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ser
385 390 395 400
Val Asp Leu Val Ser Cys Leu Gln Ile Ala Lys Gln Ile Trp Leu Ser
405 410 415
Thr Val Gly Glu Lys Pro Pro Val Lys Phe Pro Glu Phe His Trp Ser
420 425 430
Asp Glu His Arg Tyr Gln Thr Thr Ile Leu Pro Gln Gly Gln His Asp
435 440 445
Asp Asp Leu Val Leu Phe
450
<210> 96
<211> 454
<212> PRT
<213> 犬腺病毒2（Canine adenovirus 2）
<400> 96
Met Ser His Lys Lys Val Val Ala Ile Ser Glu Ser Ser Ser Asp Glu
1 5 10 15
Glu Val Pro Val Ala Pro Pro Thr Ala Pro Pro Lys Lys Arg Gln Arg
20 25 30
Lys Ala Val Glu Glu Pro Arg Gly His Gln Ala Met Val Glu Ile Ala
35 40 45
Arg Gln Ala Thr Ala Thr Leu Lys Ala Arg Gly Asp Pro Gly Ser Ile
50 55 60
Val Val Gln Thr Phe Cys Gly Gln Thr Val Asp Thr Asp Lys Glu Gly
65 70 75 80
Asn Val Val Phe Ile Pro Pro Lys Gln Lys Ser Val Trp Ser Lys Pro
85 90 95
Asn Ala Pro Ser Gly Leu Val Ala Ser Lys Phe Phe Lys Ala Ser Glu
100 105 110
His Lys Trp Gln Ser Ala Met Glu Leu Ala Leu Lys Val Leu Thr Ala
115 120 125
Tyr Gln Val Asp His Ser Lys Leu Thr Leu Leu Pro Asp Glu Gly Thr
130 135 140
Leu Glu Cys Phe Lys Lys Ala Val Gln Ala Tyr Ile Thr Thr Ser Lys
145 150 155 160
Thr His Val Thr Tyr Thr Phe Thr Asn Gln Lys Thr Phe Leu His Val
165 170 175
Ala Gly Arg Leu Leu Leu Asp Phe Val Ile Lys Ala Ala Glu Leu Ala
180 185 190
Pro Gly Val Asn Pro Ser Gly Cys Val Val Trp Gln His Gly Cys Gln
195 200 205
Ser Ser Leu Met Cys Leu His Gly Ser Pro Met Ile Gln Lys Glu Gln
210 215 220
Leu Val Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Ala Leu Lys
225 230 235 240
Glu Asn Pro Glu Lys Thr Lys Ile Val Ser Asn Arg Trp Gly Arg Asn
245 250 255
Val Val Gln Phe Lys Asn Glu Asp Ala Phe Cys Cys Ser Met Asp Val
260 265 270
Asn Met Ser Gly Gly Asn Phe Ser Gly Ala Ser Cys Gly Met Phe Tyr
275 280 285
Thr Asp Gly Pro Lys Ala Ile Met Ala Phe Gln Gln Ile Met Ala Phe
290 295 300
Leu Lys Ala Cys Tyr Pro Ser Met Pro Asn Ala Glu Ser His Leu Leu
305 310 315 320
Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Ser Asn Leu Pro Leu Leu
325 330 335
Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ser Leu Ala Ser Ala Ser
340 345 350
His Ile Asp Lys Ser Glu Val Asp Asp Gln Lys Met Leu Ala Thr Leu
355 360 365
Asn Asn Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg
370 375 380
Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ser
385 390 395 400
Val Asp Leu Val Ser Cys Val Gln Ile Ala Lys Gln Ile Trp Thr Ser
405 410 415
Thr Val Gly Glu Arg Pro Pro Ile Lys Phe Pro Glu Phe His Trp Ser
420 425 430
Asp Glu His Arg Tyr Gln Asn Thr Ile Leu Pro Gln Gly Gln His Asp
435 440 445
Asp Asp Leu Val Leu Phe
450
<210> 97
<211> 435
<212> PRT
<213> 牛腺病毒10（Bovine adenovirus 10）
<400> 97
Met Ser Gln Glu Ser Gln Asn Asp Phe Leu Thr Asn Glu Ser Val Phe
1 5 10 15
Met Asp Glu Asn Val Ala Lys Lys Ala Arg Lys Arg Pro Leu Ser Val
20 25 30
Ile Asn Thr Glu Ala Val Glu Asp Ile Glu Glu Ile Glu Glu Met Phe
35 40 45
Ser Val Gly Phe Ser Asn Pro Pro Cys Lys Leu Gly Pro Lys Gln Ile
50 55 60
Val Lys Lys Lys Ala Gly Phe Leu Thr Gly Gly Gln Leu Ser Cys Lys
65 70 75 80
Lys Ser Lys Thr Val Glu Glu Val Asp Trp Gln Lys Ala Met Asp Leu
85 90 95
Ala Val Gln Ile Leu Gln Pro Leu Lys Val Asp Ile Lys Glu Leu Thr
100 105 110
Leu Val Pro Asp Ala Tyr Lys Phe Arg Asn Phe Arg Lys Ala Met Pro
115 120 125
Lys Leu Gly Cys Asn Asp Lys Lys Ile His Leu Asn Leu Thr Phe Ser
130 135 140
Thr Gln Lys Thr Val Thr Thr Leu Met Gly Arg Phe Ile Phe Ser Phe
145 150 155 160
Val Leu Arg Ala Gly Gly Met Ala Pro Ser Asn Trp Asn Pro Thr Gly
165 170 175
Cys Val Ile Trp Asn His Lys Cys Leu Asp Asn Leu Lys Cys Phe His
180 185 190
Gly Leu Thr Met Val Ser Lys Asp Gln Leu Val Glu Met Asp Val Thr
195 200 205
Ser Glu Asn Ala Gln Arg Ala Leu Lys Glu Thr Pro Gln Lys Ala Lys
210 215 220
Ile Thr Thr Asn Arg Trp Gly Arg Ser Ile Val Gln Leu Lys Asn Glu
225 230 235 240
Asp Ala Ala Cys Cys Phe His Asp Ala Ser Cys Asn Ala Gly Thr Phe
245 250 255
Ser Asn Lys Ser Cys Gly Leu Phe Tyr Thr Glu Gly Gln Lys Ala Leu
260 265 270
Gln Ala Phe Lys Gln Ile Met Glu Phe Gln Lys Ala Cys Tyr Pro Lys
275 280 285
Met Ala Asn Ala Met Ser His Leu Leu Leu Pro Ile Lys Cys Asp Cys
290 295 300
Asn Trp Gly Thr Gly Tyr Met Pro Leu Leu Gly Arg Gln Met Cys Lys
305 310 315 320
Val Thr Pro Phe Ser Met Ser Gly Gly Arg Leu Ile Val Glu Lys His
325 330 335
Leu Ile Asp Arg Ile Pro Lys Leu Leu Ala Tyr Leu Cys Asn Asn Pro
340 345 350
Ser Ile Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg His Ser Lys
355 360 365
Ala Asn Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Val
370 375 380
Ile Leu Ala Leu Gln Leu Ala Lys Gln Met Trp Ser Ser Leu Ile Asn
385 390 395 400
Cys Pro Val Pro Leu Val Leu Glu Glu Phe Lys Trp Gln Thr Gln Tyr
405 410 415
Gln Tyr Gln Asn Thr Ile Leu Pro Val Ala Tyr Val Asp Thr Asp Glu
420 425 430
Ser Leu Phe
435
<210> 98
<211> 441
<212> PRT
<213> 猪腺病毒5（Porcine adenovirus 5）
<400> 98
Met Arg Phe Val Thr Phe Phe Ser Ile Leu His Leu Glu Lys Met Ser
1 5 10 15
Arg Asn His Tyr Glu Asp Val Ser Asp Ser Ser Ala Asp Asp Glu Pro
20 25 30
Arg Leu Val Ile Asp Asp Gln Pro Lys Pro Lys Lys Ile Ala Arg Arg
35 40 45
Arg Lys Ala Asp Gly Asp Lys Leu Asp Gly Ala Ala Lys Ser His Asp
50 55 60
Glu Ser Asn Lys Lys Arg Ala Arg Val Leu Ser Asp Thr Asp Glu Glu
65 70 75 80
Thr Pro Ser Thr Ser Val Lys Ser Ser Lys Leu Leu Leu Asp Arg Asn
85 90 95
Glu Val Lys Trp Gln Lys Ala Met Asp Val Ala Met Ser Leu Met Val
100 105 110
Pro Leu Lys Val Asp Thr Lys Asp Leu Thr Leu Leu Pro Asp His Ala
115 120 125
Thr Met Glu Cys Phe Lys Lys Ala Ala Gln Ala Trp Met Ser Asp Arg
130 135 140
Lys Lys Phe Ile Gln Leu Thr Phe Ser Thr Gln Lys Ser Leu Leu Thr
145 150 155 160
Val Met Ala Arg Phe Leu Phe Asp Phe Val Ile Arg Glu Ala Glu Leu
165 170 175
Asn Thr Pro Asp Trp Asn Pro Thr Gly Cys Val Val Trp Asn His Lys
180 185 190
Cys Gly Asp Arg Leu His Cys Leu His Gly Met Ala Met Ile Asn Lys
195 200 205
Glu Gln Leu Val Glu Met Asp Ile Asn Ser Glu Asn Gly Gln Arg Ala
210 215 220
Leu Lys Glu Thr Pro Glu Lys Ala Lys Ile Val Thr Asn Arg Trp Gly
225 230 235 240
Arg Ser Val Val Gln Ile Arg Asn Ser Asp Ala Met Cys Cys Val Asn
245 250 255
Asp Ala Lys Ser Pro Ile Asn Thr Phe Ser Pro Gln Ser Cys Gly Tyr
260 265 270
Phe Tyr Ser Asp Gly Pro Lys Ala Val Thr Ala Phe Arg Gln Ile Ala
275 280 285
Ala Phe Val Lys Ala Ile Tyr Pro Asn Met Ala Thr Ala Glu Ser His
290 295 300
Leu Leu Met Pro Leu Val Cys Glu Cys Asn Tyr Gly Ala Asn His Leu
305 310 315 320
Pro Leu Leu Gly Lys Gln Thr Cys Lys Val Thr Pro Phe Ala Met Ser
325 330 335
Thr Ala Gly Asn Ile Asp Arg Asn Leu Ile Asp Asp Pro Lys Val Leu
340 345 350
Ala Thr Leu Asp His Pro Ala Val Leu Val Phe Gln Cys Cys Asn Pro
355 360 365
Val Phe Arg Asn Thr Lys Ala Asn Pro Gln Lys Asn Cys Asp Phe Lys
370 375 380
Ile Ser Ser Thr Asp Val Val Ser Ala Leu Gln Leu Ala Lys Gln Met
385 390 395 400
Trp Gln Asn Ile Ile Gly Thr Lys Val Asn Leu Ser Val Pro Glu Phe
405 410 415
Arg Trp His Pro Gln Tyr Gln Val Gln Asn Thr Ile Leu Pro Thr Gly
420 425 430
Gln His Asp Asp Asp Asp Cys Leu Phe
435 440
<210> 99
<211> 442
<212> PRT
<213> 绵羊腺病毒A（Ovine adenovirus A）
<400> 99
Met Ser Gln Asn His Tyr Glu Asp Ile Phe Asp Ser Asp Glu Glu Gly
1 5 10 15
Lys Leu Val Ile Asp Glu Thr Pro Arg Val Lys Lys Val Thr Lys Arg
20 25 30
Lys Lys Ala Thr Glu Asp Ile Thr Pro Pro Thr Thr Pro Asp Ile Val
35 40 45
Glu Pro Ala Ser Ser Lys Lys Val Arg Val Ile Glu Ser Asp Asp Glu
50 55 60
Ala Pro Ser Thr Ser Lys Gly Lys Lys Arg Ser Val Val Ser Lys Pro
65 70 75 80
Asn Val Ser Pro Ala Ala Lys Ile Ser Arg Lys Leu Leu Asp Gln Asn
85 90 95
Glu Met Lys Trp Gln Lys Ala Met Asp Val Ala Val Ser Phe Leu Val
100 105 110
Pro Leu Lys Val Asp Ile Lys Asp Leu Thr Leu Leu Pro Asp Ala Gly
115 120 125
Thr Met Glu Cys Phe Arg Lys Gly Val Gln Ser Trp Leu Asn Glu Gln
130 135 140
Lys Arg Phe Val Pro Leu Thr Phe Ser Thr Gln Lys Ser Leu Gln Thr
145 150 155 160
Ala Val Ala Arg Phe Val Phe Asp Phe Val Leu Arg Ala Ala Glu Ile
165 170 175
Cys Pro Ala Asp Trp Asn Pro Asn Gly Cys Val Val Trp Glu His Lys
180 185 190
Thr Asn Glu Glu Lys Leu Tyr Cys Leu His Gly Leu Pro Met Ile Asn
195 200 205
Lys Glu Gln Ile Val Glu Met Asp Ile Asn Ser Glu Asn Gly Gln Arg
210 215 220
Ala Leu Lys Glu Ser Pro Glu Arg Ala Lys Ile Val Thr Asn Lys Trp
225 230 235 240
Gly Arg Ser Val Val Gln Met Lys Asn Ala Asp Ala Met Cys Cys Phe
245 250 255
Tyr Asp Leu Lys Ser Ser Leu Asn Ser Phe Ser Ser Glu Ser Cys Gly
260 265 270
Tyr Phe Tyr Ser Asp Gly Asn Lys Ala Arg Gln Gly Phe Tyr Gln Ile
275 280 285
Arg Asp Phe Val Lys Ala Met Tyr Pro Gln Met Pro Lys Ala Gly Glu
290 295 300
Met Leu Leu Met Pro Leu Val Cys Glu Cys Asn Tyr Gly His His Val
305 310 315 320
Ile Pro Leu Leu Gly Lys Gln Thr Cys Lys Val Thr Pro Phe Ala Leu
325 330 335
Asn Ala Val Ser Asn Ile Asp Arg Ser Leu Val Glu Asp Ala Lys Val
340 345 350
Leu Ala Thr Leu Asn Asn Pro Val Val Leu Val Phe Gln Cys Cys Asn
355 360 365
Pro Val Phe Arg Asn Thr Lys Ala Asn Pro Gln Lys Asn Cys Asp Phe
370 375 380
Lys Ile Ser Ser Thr Asp Val Val Met Ala Leu Gln Leu Ala Lys Gln
385 390 395 400
Met Trp Ser Ser Leu Thr Gly Thr Lys Ala Ser Ile Val Val Gln Glu
405 410 415
Phe Lys Trp Gln Pro Gln Tyr Arg Val Gln Asn Thr Leu Leu Pro Thr
420 425 430
Gly Gln Asp Asp Ala Asp Glu Cys Leu Phe
435 440
<210> 100
<211> 457
<212> PRT
<213> 猪腺病毒3（Porcine adenovirus 3）
<400> 100
Met Ser Arg Arg Tyr Ser Asp Val Ser Asp Tyr Asp Ser Gly Glu Glu
1 5 10 15
Gly Val Leu Ile Val Asp Asp Ala Pro Val Ala Thr Pro Ser Arg Arg
20 25 30
Gly Gly Gly Arg Lys Arg Ala Ala Ser Pro Pro Val Gln Glu Arg Arg
35 40 45
Lys Arg Ala Arg Ala Lys Pro Leu Val Ser Glu Glu Glu Glu Asp Glu
50 55 60
Ala Glu Glu Thr Ala Ala Ala Thr Ala Arg Pro Ala Arg Arg Lys Gly
65 70 75 80
Glu Asp Gly Glu Glu Glu Glu Gly Ala Arg Pro Pro Arg Pro Val Thr
85 90 95
Pro Ser Pro Ala Val Ala Arg Pro Leu Leu Gln Leu Asp Ala Gln Glu
100 105 110
Gln Lys Trp Gln Arg Ala Met Asp Leu Ala Val Gln Met Leu Val Pro
115 120 125
Leu Lys Val Asp Val Lys Gly Leu Thr Leu Leu Pro Asp Gly Ser Thr
130 135 140
Leu Glu Cys Phe Arg Arg Gly Ala Gln Ala Trp Leu Asn Glu Arg Lys
145 150 155 160
Ile Ser Cys Gln Leu Thr Phe Ser Thr Gln Lys Ser Leu Leu Thr Val
165 170 175
Met Ala Arg Phe Leu Leu Asp Phe Val Val Lys Ala Ala Gly Leu Lys
180 185 190
Thr Pro Glu Trp Asn Pro Cys Gly Cys Val Ile Trp Gln His Arg Ser
195 200 205
Gly Ser Glu Gly Leu His Cys Leu His Gly Leu Pro Met Ile Asn Lys
210 215 220
Glu Gln Leu Val Glu Met Asp Leu Asn Ser Glu Asn Gly Gln Arg Ala
225 230 235 240
Leu Arg Glu Thr Pro Glu Arg Ala Lys Ile Thr Thr Asn Arg Trp Gly
245 250 255
Arg Asn Val Val Gln Leu Arg Asn Asp Gly Ala Met Cys Cys Ser His
260 265 270
Asp Val Gly Ser Ala Pro Asn Thr Phe Ser Ala Arg Ser Cys Gly Leu
275 280 285
Phe Tyr Ser Glu Gly Ser Lys Ala Gln Gln Ala Phe Glu Gln Leu Lys
290 295 300
Ala Phe Gln Lys Ala Cys Tyr Pro Arg Met Gly Asn Ala Glu Thr His
305 310 315 320
Leu Leu Met Pro Leu Val Cys Asp Cys Gly Trp Gly Cys Arg Gln Val
325 330 335
Pro Leu Leu Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ala Leu Ser
340 345 350
Gly Ser Ala Ala Leu Asn Pro Gln Leu Val Glu Asp Pro Lys Ile Leu
355 360 365
Ala Ser Val Thr His Pro Ala Val Leu Val Phe Gln Cys Tyr Asn Pro
370 375 380
Val Tyr Arg Gly Ser Arg Gly Asn Pro Gln Lys Asn Cys Asp Phe Lys
385 390 395 400
Ile Ser Ala Pro Asp Val Met Leu Ala Leu Gln Leu Thr Lys Gln Met
405 410 415
Trp Ala Ala Leu Met Gln Thr Arg Pro Pro Leu Thr Val Pro Glu Phe
420 425 430
Lys Trp Gly Pro Gln Phe Gln Val Gln Asn Thr Ile Phe Pro Val Gly
435 440 445
Thr Glu Asp Asp Asp Glu Ser Leu Phe
450 455
<210> 101
<211> 432
<212> PRT
<213> 牛腺病毒B（Bovine adenovirus B）
<400> 101
Met Asn Arg Ser Gly Asp Leu Thr Arg Ala Thr Ser Ser Ala Asp Ser
1 5 10 15
Ser Gly Asp Glu Asn Pro Leu Val Ile Asp Glu Thr Pro Arg Lys Lys
20 25 30
Val Ser Arg Lys Arg Arg Ala Pro Ile Ala Glu Pro Pro Ala Glu Asp
35 40 45
Val Thr Ala Val Lys Arg Ala Lys Ile Phe Lys Pro Ser Ala Pro Ala
50 55 60
Ala Glu Ala Ala Ala Pro Ala Leu Pro Ala Ala Ser Arg Ala Leu Leu
65 70 75 80
Glu Ala Asp Glu Val Ala Trp Gln Arg Ala Met Glu Leu Ala Val Gly
85 90 95
Leu Cys Val Pro Leu Lys Val Asp Ile Lys Asn Leu Thr Leu Leu Pro
100 105 110
Asp Thr Gly Thr Leu Glu Cys Phe Arg Lys Val Ala Gln Ala Trp Leu
115 120 125
Asn Glu Ser Lys Val Tyr Leu Pro Leu Thr Phe Ser Thr Gln Lys Thr
130 135 140
Val Leu Thr Ile Met Gly Arg Phe Leu Tyr Asp Phe Val Leu Lys Val
145 150 155 160
Ala Gly Leu Gly Thr Thr Ser Trp Ser Pro Thr Gly Cys Val Val Trp
165 170 175
Arg His Gln Cys Thr Glu Gly Gly Asp Gly Ala Leu His Cys Leu His
180 185 190
Gly Leu Pro Met Leu Thr Lys Asp Gln Val Ile Glu Met Asp Val Asn
195 200 205
Ser Glu Asn Gly Gln Arg Ala Leu Lys Glu Thr Pro His Lys Thr Lys
210 215 220
Ile Thr Thr Asn Arg Trp Asn Met Asn Val Val Gln Leu Lys Asn Glu
225 230 235 240
Asp Ala Ala Cys Cys His Phe Asp Ala Ala Leu Pro Ala Gly Ser Phe
245 250 255
Thr Ser Lys Ser Cys Gly Met Phe Phe Ser Glu Gly Pro Lys Ala Leu
260 265 270
Gln Ala Phe Trp Gln Ile Met Thr Phe Gln Lys Ala Cys Tyr Pro Arg
275 280 285
Met Gln Ser Ala Gly Thr His Leu Leu Met Pro Leu Lys Cys Asp Cys
290 295 300
Asn Trp Gly His Ser Gln Leu Pro Leu Leu Gly Arg Gln Val Cys Lys
305 310 315 320
Ile Thr Pro Phe Asn Ile Asn Ala Gly Ser Ala Val Asp Lys Ser Leu
325 330 335
Val Glu Asp Pro Lys Leu Leu Ala Ser Val Glu His Pro Ser Val Leu
340 345 350
Val Phe Gln Cys Cys Asn Pro Val Tyr Arg Gln Thr Arg Ala Asn Ala
355 360 365
Gln Arg Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Met Ile Ser Ala
370 375 380
Leu Gln Leu Val Lys Gln Met Trp Ser Ala Leu Val Lys Gln Ser Pro
385 390 395 400
Pro Ile Thr Ile Pro Glu Phe Arg Trp Asp Pro Gln Tyr Gln His Gln
405 410 415
Asn Val Ile Leu Pro Ile Asp Gln Tyr Asp Ala Asp Asp Ser Leu Phe
420 425 430
<210> 102
<211> 467
<212> PRT
<213> 树鼩腺病毒（Tree shrew adenovirus）
<400> 102
Met Ser Asp Arg His Asp Tyr Ser Ser Asp Ser Ser Ser Asp Met Ile
1 5 10 15
Ile Cys Glu Asn Glu Pro Ala Pro Lys Glu Thr Gln Gly Pro Ser Val
20 25 30
Met Arg Val Gly Phe Ser Asn Pro Pro Val Glu Ile Ile Arg Ser Gly
35 40 45
Gly Gly Lys Thr Thr His Lys Ser Leu Gly Pro Asn Trp Arg Arg Lys
50 55 60
Leu Pro Ser Leu Asp Gln Leu Met Lys Gly Glu Pro Ala Asp Glu Ser
65 70 75 80
Ser Gln Asp Ser Thr Lys Ser Ser Pro Glu Lys Arg Pro Ser Thr Ser
85 90 95
Gly Glu Pro Ala Ala Ile Lys Lys Arg Arg Lys Ala Val Val Pro Asn
100 105 110
Lys Leu Val Ser Ser Asp Glu Thr Lys Trp Gln Met Val Met Asp Met
115 120 125
Ala Val Asn Met Leu Thr Pro Leu Lys Val Asp Leu Lys Asp Leu Thr
130 135 140
Met Leu Ala Asp Gln Gly Thr Leu Glu Cys Phe Gln Lys Ala Ala Gln
145 150 155 160
Ala Trp Met Thr Glu Arg Lys Ile Tyr Thr Pro Leu Thr Tyr Ser Thr
165 170 175
Gln Lys Thr Leu Leu Ser Leu Met Gly Arg Phe Leu Phe His Phe Ile
180 185 190
Met Thr Lys Val Gly Glu Ser Asp His Gly Gly Lys Ala Trp Pro Lys
195 200 205
Asn Thr Asn Val Ser Gly Ala Val Val Trp Lys His Gln Ser Gly Ala
210 215 220
Thr Leu Ser Cys Leu His Gly Leu Thr Met Leu Asn Lys Glu Gln Ile
225 230 235 240
Val Glu Met Asp Val Ser Ser Glu Asn Gly Gln Arg Ala Leu Lys Glu
245 250 255
Thr Pro Glu Lys Thr Lys Ile Thr Thr Asn Arg Trp Gly Arg Asn Val
260 265 270
Val Gln Val Arg Asn Glu Asp Ala Met Cys Cys Gln Phe Asp Ala Pro
275 280 285
Leu Pro Ala Asn Asn Phe Ser Thr Lys Ser Cys Gly Met Phe Tyr Ser
290 295 300
Glu Gly Glu Lys Ala Lys Thr Ala Phe Lys Gln Ile Met Ala Leu Gln
305 310 315 320
Arg Ala Cys Tyr Pro Lys Met Asp Gly Glu Gln Ile Val Ile Pro Ile
325 330 335
Lys Cys Asp Cys Asn Trp Ala Ser Thr Thr Pro Leu Leu Gly Arg Gln
340 345 350
Val Cys Lys Val Thr Pro Phe Thr Ile Ser Ala Thr Glu Ser Ile Asp
355 360 365
Arg Glu Leu Val Gln Asp Pro Lys Ile Leu Ala Thr Val His Asn Pro
370 375 380
Ala Val Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg Asn Ser Arg
385 390 395 400
Ala Asn Pro Gln Lys Asn Cys Asp Trp Lys Ile Ser Ala Pro Asp Val
405 410 415
Met Thr Ala Leu Gln Leu Ala Lys Gln Met Trp Gln His Val Phe Lys
420 425 430
Glu Pro Pro Val Val Arg Ile Pro Glu Phe Lys Trp Ser Ala Ala Tyr
435 440 445
Gln Tyr Gln Asn Thr Ile Leu Pro Thr Gly Val Asp Asp Thr Asp Asp
450 455 460
Ser Leu Phe
465
<210> 103
<211> 529
<212> PRT
<213> 人腺病毒5（Human adenovirus 5）
<400> 103
Met Ala Ser Arg Glu Glu Glu Gln Arg Glu Thr Thr Pro Glu Arg Gly
1 5 10 15
Arg Gly Ala Ala Arg Arg Pro Pro Thr Met Glu Asp Val Ser Ser Pro
20 25 30
Ser Pro Ser Pro Pro Pro Pro Arg Ala Pro Pro Lys Lys Arg Met Arg
35 40 45
Arg Arg Ile Glu Ser Glu Asp Glu Glu Asp Ser Ser Gln Asp Ala Leu
50 55 60
Val Pro Arg Thr Pro Ser Pro Arg Pro Ser Thr Ser Ala Ala Asp Leu
65 70 75 80
Ala Ile Ala Pro Lys Lys Lys Lys Lys Arg Pro Ser Pro Lys Pro Glu
85 90 95
Arg Pro Pro Ser Pro Glu Val Ile Val Asp Ser Glu Glu Glu Arg Glu
100 105 110
Asp Val Ala Leu Gln Met Val Gly Phe Ser Asn Pro Pro Val Leu Ile
115 120 125
Lys His Gly Lys Gly Gly Lys Arg Thr Val Arg Arg Leu Asn Glu Asp
130 135 140
Asp Pro Val Ala Arg Gly Met Arg Thr Gln Glu Glu Glu Glu Glu Pro
145 150 155 160
Ser Glu Ala Glu Ser Glu Ile Thr Val Met Asn Pro Leu Ser Val Pro
165 170 175
Ile Val Ser Ala Trp Glu Lys Gly Met Glu Ala Ala Arg Ala Leu Met
180 185 190
Asp Lys Tyr His Val Asp Asn Asp Leu Lys Ala Asn Phe Lys Leu Leu
195 200 205
Pro Asp Gln Val Glu Ala Leu Ala Ala Val Cys Lys Thr Trp Leu Asn
210 215 220
Glu Glu His Arg Gly Leu Gln Leu Thr Phe Thr Ser Asn Lys Thr Phe
225 230 235 240
Val Thr Met Met Gly Arg Phe Leu Gln Ala Tyr Leu Gln Ser Phe Ala
245 250 255
Glu Val Thr Tyr Lys His His Glu Pro Thr Gly Cys Ala Leu Trp Leu
260 265 270
His Arg Cys Ala Glu Ile Glu Gly Glu Leu Lys Cys Leu His Gly Ser
275 280 285
Ile Met Ile Asn Lys Glu His Val Ile Glu Met Asp Val Thr Ser Glu
290 295 300
Asn Gly Gln Arg Ala Leu Lys Glu Gln Ser Ser Lys Ala Lys Ile Val
305 310 315 320
Lys Asn Arg Trp Gly Arg Asn Val Val Gln Ile Ser Asn Thr Asp Ala
325 330 335
Arg Cys Cys Val His Asp Ala Ala Cys Pro Ala Asn Gln Phe Ser Gly
340 345 350
Lys Ser Cys Gly Met Phe Phe Ser Glu Gly Ala Lys Ala Gln Val Ala
355 360 365
Phe Lys Gln Ile Lys Ala Phe Met Gln Ala Leu Tyr Pro Asn Ala Gln
370 375 380
Thr Gly His Gly His Leu Leu Met Pro Leu Arg Cys Glu Cys Asn Ser
385 390 395 400
Lys Pro Gly His Ala Pro Phe Leu Gly Arg Gln Leu Pro Lys Leu Thr
405 410 415
Pro Phe Ala Leu Ser Asn Ala Glu Asp Leu Asp Ala Asp Leu Ile Ser
420 425 430
Asp Lys Ser Val Leu Ala Ser Val His His Pro Ala Leu Ile Val Phe
435 440 445
Gln Cys Cys Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Gly Gly Gly
450 455 460
Pro Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Asn Ala Leu
465 470 475 480
Val Met Val Arg Ser Leu Trp Ser Glu Asn Phe Thr Glu Leu Pro Arg
485 490 495
Met Val Val Pro Glu Phe Lys Trp Ser Thr Lys His Gln Tyr Arg Asn
500 505 510
Val Ser Leu Pro Val Ala His Ser Asp Ala Arg Gln Asn Pro Phe Asp
515 520 525
Phe
<210> 104
<211> 215
<212> PRT
<213> 小鼠腺病毒1（Murine adenovirus 1）
<400> 104
Met Ser Ala Pro Ser Pro Tyr Val Trp Thr Phe Gln Pro Gln Arg Gly
1 5 10 15
Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Ile Asn Trp Leu
20 25 30
Ser Ala Gly Pro Glu Leu Arg Gly Lys Val Val Gln Leu Asn Glu Ala
35 40 45
Arg Asn Ala Ile Leu Met Lys Glu Gln Glu Ser Val Pro Thr Pro Arg
50 55 60
Ala Glu Ala Asn Pro Ser Phe Trp Pro Ala Ala Leu Ile Phe Gln Pro
65 70 75 80
Arg Pro Gln Ala Ile Pro Val His Pro Ala His Pro Asp Thr Phe Asp
85 90 95
Ala Ala Leu Thr Ser Asn Gly Ala Gln Leu Ala Gly Gly Ala Trp Ile
100 105 110
Asn Tyr Lys Asn Gly Ser Val Arg Tyr Glu Ala Pro Leu Gln Leu Ala
115 120 125
Glu Glu Gln Val Gly Gly Pro Leu Asn Ala Phe Ala Ile Lys His Gln
130 135 140
Leu Gln Leu Ala Gly Gly Ala Leu Ser Ala Ser Met Ser Glu Met Ser
145 150 155 160
Gly Ala Pro Arg Ile Pro Arg Ser Gly Gly Ile Gly Ser Trp Gln Phe
165 170 175
Ser Arg Glu Phe Pro Pro Thr Val Tyr Leu Asn Pro Phe Ser Gly Ser
180 185 190
Pro Asp Thr Phe Pro His Gln Phe Leu Ser Asn Tyr Asp Ser Phe Ser
195 200 205
His Thr Val Asp Gly Tyr Asp
210 215
<210> 105
<211> 218
<212> PRT
<213> 小鼠腺病毒3（Murine adenovirus 3）
<400> 105
Met Ser Ala Pro Ser Pro Tyr Met Trp Thr Phe Gln Pro Gln Arg Gly
1 5 10 15
Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Leu Asn Trp Leu
20 25 30
Ser Ala Gly Pro Ser Leu Arg Gly Lys Val Ile Glu Val Asn Gln Ala
35 40 45
Arg Asn Ser Ile Leu Leu Asn Gln Gln Glu Ala Val Pro Thr Pro Arg
50 55 60
Arg Asp Ile Asn Pro Pro Ser Trp Pro Ala Ser Leu Ile Phe His Pro
65 70 75 80
Arg Pro Lys Pro Ile Ala Val Leu Pro Ala His Pro Asp Ser Phe Asp
85 90 95
Pro Asn Val Thr Leu Glu Gly Ala Gln Leu Ala Gly Gly Ala Trp Val
100 105 110
Arg Tyr Lys Ser Gly Asn Glu Val Arg Tyr Thr Ala Pro Ile Gln Leu
115 120 125
Ala Glu Glu Pro Thr Ser Arg Thr Pro Thr Ala Tyr Ala Leu Ala Gln
130 135 140
Glu Leu Gln Leu Ala Gly Gly Ala Thr Ala Thr Pro Pro Leu Met Gly
145 150 155 160
Glu Leu Ala Gly Ala Pro Arg Val Pro Arg Ser Gly Gly Ile Gly Ser
165 170 175
Trp Gln Phe Thr Gln Glu Phe Pro Pro Thr Val Tyr Leu Asn Pro Tyr
180 185 190
Ser Gly Ala Pro Asp Thr Phe Pro His Gln Phe Leu Ser Asn Tyr Asp
195 200 205
Ser Val Ser Gln Ser Val Asn Gly Tyr Asp
210 215
<210> 106
<211> 217
<212> PRT
<213> 绵羊腺病毒7（Ovine adenovirus 7）
<400> 106
Met Ala Gln Pro Val Thr Pro Tyr Val Trp Lys Tyr Gln Pro Glu Thr
1 5 10 15
Gly Tyr Thr Ala Gly Ala His Gln Asn Tyr Asn Thr Val Ile Asn Trp
20 25 30
Leu His Ala Asn Pro Gln Met Phe Ala Arg Ile Gln His Ile Asn Thr
35 40 45
Ala Arg Asn Val Met Asp Lys Phe Arg Ser Asp Leu Thr Arg Asp Asp
50 55 60
Ile Ala Val Asn Ile Asn Asn Trp Pro Ala Glu Asp Leu Met Gln Pro
65 70 75 80
Pro Asn Phe Pro Tyr Ile Pro Ala Thr Ser Lys Ser Ala Ser Thr Ile
85 90 95
Asn Asp Trp Leu Ala Thr Thr Gln Gly Ile Gln Leu Ser Gly Thr Ser
100 105 110
Glu Leu Asn Gly Trp Gly Ser Asn Arg Leu Thr Ser Tyr Pro Asp Ile
115 120 125
Pro Pro Ile Leu Lys Tyr Glu Arg Pro Gly Gln Gln Leu Gln Gly Gln
130 135 140
Gly Leu Phe Lys Gln Glu Asn Ile His Leu Phe Tyr Glu Ser Pro Arg
145 150 155 160
Leu Pro Arg Ser Gly Gly Leu Thr Pro Gln Gln Phe Val Lys Glu Phe
165 170 175
Pro Pro Val Val Tyr Asn Asn Pro Phe Ser Glu Ser Met Ser Val Phe
180 185 190
Pro Lys Glu Phe Ser Pro Leu Phe Asn Pro Ser Glu Ser Leu Lys Lys
195 200 205
Thr Ser Ser Gln Thr Leu Gln Tyr Lys
210 215
<210> 107
<211> 217
<212> PRT
<213> 绵羊腺病毒D（Ovine adenovirus D）
<400> 107
Met Ala Gln Pro Val Thr Pro Tyr Val Trp Lys Tyr Gln Pro Glu Thr
1 5 10 15
Gly Tyr Thr Ala Gly Ala His Gln Asn Tyr Asn Thr Val Ile Asn Trp
20 25 30
Leu His Ala Asn Pro Gln Met Phe Ala Arg Ile Gln His Ile Asn Thr
35 40 45
Ala Arg Asn Val Met Asp Lys Phe Arg Ser Asp Leu Thr Arg Asp Asp
50 55 60
Ile Ala Val Asn Ile Asn Asn Trp Pro Ala Glu Asp Leu Met Gln Pro
65 70 75 80
Pro Asn Phe Pro Tyr Ile Pro Ala Thr Ser Lys Ser Ala Ser Thr Ile
85 90 95
Asn Asp Trp Leu Ala Thr Thr Gln Gly Ile Gln Leu Ser Gly Thr Ser
100 105 110
Glu Leu Asn Gly Trp Gly Ser Asn Arg Leu Thr Ser Tyr Pro Asp Ile
115 120 125
Pro Pro Ile Leu Lys Tyr Glu Arg Pro Gly Gln Gln Leu Gln Gly Gln
130 135 140
Gly Leu Phe Lys Gln Glu Asn Ile His Leu Phe Tyr Glu Ser Pro Arg
145 150 155 160
Leu Pro Arg Ser Gly Gly Leu Thr Pro Gln Gln Phe Val Lys Glu Phe
165 170 175
Pro Pro Val Val Tyr Asn Asn Pro Phe Ser Glu Ser Met Ser Val Phe
180 185 190
Pro Lys Glu Phe Ser Pro Leu Phe Asn Pro Ser Glu Ser Leu Lys Lys
195 200 205
Thr Ser Ser Gln Thr Leu Gln Tyr Lys
210 215
<210> 108
<211> 222
<212> PRT
<213> 牛腺病毒4（Bovine adenovirus 4）
<400> 108
Met Gln Pro Val Thr Pro Tyr Ile Trp Lys Tyr Gln Pro Glu Thr Gly
1 5 10 15
His Thr Ala Gly Ala His Gln Asp Tyr Gly Ser Val Ile Asn Trp Leu
20 25 30
Gln Ser Asn Pro Gln Met Phe Asn Arg Ile Arg Asp Ile Asn Leu Gln
35 40 45
Arg Asn Asn Ile Asp Gln Thr Gln Gly Leu Met Thr Arg Asp Asp Leu
50 55 60
His Ser Asn Ile Asn Asn Trp Pro Ala Ser Gln Val Leu Gln Arg Gln
65 70 75 80
Gly Phe Pro Tyr Val Pro Ala Lys Met Asn Leu Glu Ala Ser Lys Gln
85 90 95
Asp Phe Ile Asp Ser Ala Arg Gly Ile Gln Leu Ser Gly Pro Asn Pro
100 105 110
Val Phe Thr Gly Thr Gly Ser Asn Asn Leu Thr Ser Tyr Pro Met Leu
115 120 125
Thr Glu Asn Ile Pro Pro Leu Met Leu Tyr His Arg Pro Gly Gln Gln
130 135 140
Leu Gln Gly Met Gly Thr Ile Ser Lys Glu Asn Phe His Leu Leu Glu
145 150 155 160
Glu Val Ser Arg Val Pro Arg Ser Gly Gly Leu Thr Pro Thr Glu Phe
165 170 175
Leu Thr Gln Phe Pro Pro Ile Val Tyr Arg His Pro Phe Ser Ser Ser
180 185 190
Leu Ile Tyr Phe Pro Lys Glu Phe Asp Pro Leu Phe Ser Pro His Asn
195 200 205
Asp Pro Arg Leu Thr Ser Ser Lys Thr Leu Gln Tyr Val Pro
210 215 220
<210> 109
<211> 250
<212> PRT
<213> 鸭腺病毒1（Duck adenovirus 1）
<400> 109
Met Gln Pro Val Thr Pro Tyr Leu Trp Arg Tyr Gln Pro Glu Thr Gly
1 5 10 15
Thr Ala Ala Gly Ala Arg Gln Asp Tyr Gly Ala Val Ile Asn Trp Phe
20 25 30
Asn Ser Gly Pro Asp Leu Tyr Arg Arg Ile Arg Asp Val Asn Ile Thr
35 40 45
Arg Asn Asn Val Glu Gln Thr Arg Ala Leu Ala Arg Thr Pro Leu Ser
50 55 60
Gly Asn Phe Asn Arg Trp Thr Ala Ala Gln Leu Thr His Pro Pro Gly
65 70 75 80
Thr Arg Tyr Lys Pro Tyr Phe Pro Val Asp Ser Ile Lys Gly Ala Arg
85 90 95
Asp Arg Val Ala Thr Gln Gln Gly Gln Ile Leu Ala Gly Ala Gly Tyr
100 105 110
Asp Leu His Asp Gly Arg Gln Tyr Arg Lys Ile Thr Arg Asp Ala Leu
115 120 125
Pro Phe Pro His Asn Trp Gln Val Lys Asp Gly Ser Arg Trp Val Asn
130 135 140
Leu Gly Gly Lys Gly Ala Asn Ser Leu Thr Thr Tyr Pro Val Ile Ala
145 150 155 160
Asp Ile Pro Pro Ile Met Arg Tyr Gly Arg Pro Gly Gln Gln Leu Gln
165 170 175
Gly Ser Gly Phe His Arg Pro Ser Pro Ala Leu Leu Thr Glu Glu Ala
180 185 190
Arg Val Pro Arg Ser His Gly Met Thr Val Arg Gln Phe Val His Glu
195 200 205
Phe Pro Pro Val Val Phe Asn His Pro Phe Ser Glu Asp Ile Thr Tyr
210 215 220
Phe Pro Lys Glu Phe Asn Pro Leu Phe Asn Pro Ser Glu Asp Tyr Arg
225 230 235 240
Val Ser Ser Asp Arg Thr Leu Gln Tyr Val
245 250
<210> 110
<211> 278
<212> PRT
<213> 蛇腺病毒（Snake adenovirus）
<400> 110
Met Glu Ala Pro Val Thr Pro Tyr Ile Trp Gln Tyr Gln Pro Glu Thr
1 5 10 15
Gly Thr Ala Ala Gly Ala Arg Gln Asn Tyr Gly Ala Val Ile Asn Trp
20 25 30
Leu Ser Ser Asp Asn Asn Met Tyr His Arg Val Gln Glu Val Asn Arg
35 40 45
Gln Arg Asn Lys Ile Asp Asp Phe Arg Glu Gln Thr Val Arg Ala Asp
50 55 60
Met Ala His Ser Phe Asn Asp Trp Lys Pro Gln Gln Leu Ser Gln Pro
65 70 75 80
Ala Ser Thr Ala Tyr Leu Pro Ala Pro Asn Pro Ile Ala Gly Pro Arg
85 90 95
Thr Ile Pro Asp Val Ile Phe Thr Ala Glu Gly Glu Gln Leu Ala Gly
100 105 110
Ala Ser Pro Ser Leu Leu Ser Gly Gly Ala Ser Leu Pro Pro Ser Ser
115 120 125
Tyr Arg Leu Gly Asp Gly Arg Glu Tyr Arg Lys Phe Thr Arg Asp Ala
130 135 140
Met Pro Phe Pro His Asn Trp Leu Val Lys Glu Asn Gly Val Trp Val
145 150 155 160
Pro Val Glu Glu Arg Asp Pro Leu Leu Ser Glu Glu Gly Arg Asn Ala
165 170 175
Leu Ser Ser Tyr Pro Thr Leu Thr Tyr Ala Gln Pro Pro Ile Leu Arg
180 185 190
Tyr Arg Arg Leu Gly Gln Gln Leu Gln Gly Gly Gly Val Val Ala Pro
195 200 205
Ser Ser Arg Val Val Ser Leu Leu Thr Glu Gln Pro Arg Met Pro Arg
210 215 220
Thr Glu Gly Met Thr Pro Tyr Gln Phe Ser Ala Glu Phe Pro Pro Val
225 230 235 240
Val Tyr Asp His Pro Phe Ser Arg Asn Leu Thr Leu Phe Pro Lys Glu
245 250 255
Phe Ser Pro Leu Phe Asp Pro Lys Asp Gln Val Leu Ala Thr Ser Leu
260 265 270
Ala Thr Leu Gln Tyr Arg
275
<210> 111
<211> 246
<212> PRT
<213> 禽腺病毒10（fowl adenovirus 10）
<400> 111
Met Asn Leu Leu Asn Ala Ala Pro Thr Pro Tyr Val Trp Lys Tyr Asn
1 5 10 15
Pro Val Thr Gly Lys Cys Ala Gly Ala Asn Arg Thr Thr Ala His Tyr
20 25 30
Arg Leu Val Leu Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp Glu
35 40 45
Ile Arg Arg Arg Phe Pro Glu Pro Ala Val Thr Arg Ala Ile Thr Ala
50 55 60
Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Tyr Ala Gly Pro His Glu
65 70 75 80
Thr Asn Ile Ile Thr Ala Asp Val Val Arg Ser Gly Pro Pro Pro Ser
85 90 95
Ala Val Tyr Pro Phe Asp Pro Ser Gly Val Gln Arg Val Gln Leu Ser
100 105 110
Gly Gly Met Met Gly Gly Arg Thr Glu Gly Arg Val Gln Leu Ser Gly
115 120 125
Gly Leu Thr Glu Gly Arg Met Gln Leu Ala Gly Gly Ala Ala Gly Lys
130 135 140
Leu Pro Thr Arg Ala Arg Pro Thr Leu Arg Pro Pro Arg Trp Cys Gly
145 150 155 160
Thr Thr Leu Thr Gly Asn Gly Leu Pro Ala Asp Tyr Pro Glu Met Thr
165 170 175
Pro Asp Ala Phe Lys Tyr Tyr Leu Arg Val Gln Gly Pro Ser Gln Glu
180 185 190
Val Asp Glu Pro Gly Val Met Ser Gln Arg Gln Phe Met Thr Thr Phe
195 200 205
Leu Pro Ala Met Val Pro His Pro Phe Asp Ser Glu Ser Pro Asp Ala
210 215 220
Phe Pro Ala Tyr Phe Ser Ser Val Tyr Lys Gly Thr Asn Gly Phe Glu
225 230 235 240
Pro Val Phe Trp Gln Gly
245
<210> 112
<211> 244
<212> PRT
<213> 禽腺病毒8（Fowl adenovirus 8）
<400> 112
Met Asn Leu Leu Glu Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn
1 5 10 15
Pro Leu Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr
20 25 30
Ile Asn Trp Val Val Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp
35 40 45
Glu Ile Arg Arg His Thr Leu Ser Pro Ala Ala Thr Arg Ala Ile Thr
50 55 60
Glu Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Phe Ala Asn Ala Arg
65 70 75 80
Glu Thr Ala Tyr Ile Thr Ala Asn Val Leu Asp Ser Gly Phe Pro Lys
85 90 95
Ser Ala Val Tyr Pro Val Asp Pro Ser Gly Val Gln Arg Val Gln Leu
100 105 110
Ser Gly Gly Ala Glu Gly Arg Met Gln Leu Ala Gly Gly Leu Thr Glu
115 120 125
Gly Arg Val Gln Leu Ser Gly Gly Val Leu Gly His Val Val Pro Pro
130 135 140
Gly Gly Arg Arg Arg Ala Gly Gly Arg Pro Pro Arg Trp Cys Gly Thr
145 150 155 160
Ala Leu Ala Gly Asn Gly Leu Pro Glu Asp Ala Glu Val Val Ser Asp
165 170 175
Thr Tyr Lys Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val Gln
180 185 190
Glu Pro Gly Val Tyr Ser Arg Arg Gln Phe Met Thr Thr Phe Leu Pro
195 200 205
Ala Val Val Pro Arg Pro Phe Ser Ser Pro Asn Pro Arg Asp Phe Pro
210 215 220
Ala Gln Tyr Ser Ala Ile Tyr Lys Gly Thr Asn Ala Tyr Glu Asp Val
225 230 235 240
Phe Trp Asp Trp
<210> 113
<211> 241
<212> PRT
<213> 禽腺病毒9（Fowl adenovirus 9）
<400> 113
Met Asn Leu Leu Asp Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn
1 5 10 15
Pro Leu Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr
20 25 30
Ile Asn Trp Val Val Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp
35 40 45
Glu Ile Arg Arg Asn Thr Leu Ser Pro Ala Val Thr Arg Ala Ile Thr
50 55 60
Ala Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Phe Ala Asn Pro Arg
65 70 75 80
Glu Thr Ala Tyr Ile Thr Ala Asn Val Leu Asp Ser Gly Phe Pro Lys
85 90 95
Ser Ala Val Tyr Pro Val Asp Pro Ser Gly Val Gln Lys Val Gln Leu
100 105 110
Ala Gly Gly Ala Glu Gly Arg Met Gln Leu Ser Gly Gly Leu Thr Glu
115 120 125
Gly Arg Val Gln Leu Ser Gly Gly Val Leu Gly His Val Pro Arg Arg
130 135 140
Ser Arg Arg Gly Ala Arg Pro Pro Arg Trp Cys Gly Thr Ala Leu Ala
145 150 155 160
Gly Asn Gly Leu Pro Glu Asp Ala Glu Met Val Ser Asp Thr Tyr Lys
165 170 175
Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val Ser Glu Pro Gly
180 185 190
Val Tyr Ser Gln Arg Gln Phe Met Thr Thr Phe Leu Pro Ala Val Val
195 200 205
Pro His Pro Phe Asp Ser Pro Asn Pro Asn Asp Phe Pro Ala Gln Tyr
210 215 220
Ser Ala Ile Tyr Lys Gly Thr Asn Ala Tyr Glu Asp Val Phe Trp Asp
225 230 235 240
Trp
<210> 114
<211> 245
<212> PRT
<213> 禽腺病毒1（fowl adenovirus 1）
<400> 114
Met Asn Leu Met Asn Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn
1 5 10 15
Pro Val Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr
20 25 30
Ile Asp Trp Val Leu Pro Gly Gly Thr Gly Phe Ala Ile Ala Thr Asn
35 40 45
Asp Ile Arg Arg Gln Thr Leu Asn Pro Ala Val Thr Arg Ala Ile Thr
50 55 60
Ala Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Tyr Ala Ser Pro His
65 70 75 80
Glu Thr Asn Val Ile Ala Ala Asn Val Leu Asp Ser Gly Tyr Pro Lys
85 90 95
Ser Gly Leu Tyr Pro Leu Glu Leu Ser Gly Asn Gln Arg Val Gln Leu
100 105 110
Ala Gly Gly Leu Met Val Gly Arg Thr Glu Gly Arg Met Gln Leu Ala
115 120 125
Gly Gly Leu Thr Glu Gly Arg Val Gln Leu Ser Gly Gly Phe His Gly
130 135 140
Arg Pro Leu Val Arg Gly Arg Ser Arg Arg Pro Pro Arg Trp Cys Gly
145 150 155 160
Ala Glu Leu Thr Gly Asn Gly Leu Pro Glu Gln Ala Glu Val Thr Ser
165 170 175
Asp Thr Tyr Lys Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val
180 185 190
Glu Glu Pro Gly Val Phe Ser Gln Arg Gln Phe Met Thr Thr Phe Leu
195 200 205
Pro Ser Val Val Pro His Pro Phe Asp Ser Thr Asn Pro Gly Asp Phe
210 215 220
Pro Ala Gln Tyr Ser Ala Ile Tyr Lys Gly Arg Thr Ala Phe Glu Asp
225 230 235 240
Thr Phe Trp Asp Trp
245
<210> 115
<211> 200
<212> PRT
<213> 土耳其腺病毒3（Turkey adenovirus 3）
<400> 115
Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr
1 5 10 15
Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val
20 25 30
Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys
35 40 45
Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly
50 55 60
Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn
65 70 75 80
Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln
85 90 95
Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu
100 105 110
Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys
115 120 125
Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly
130 135 140
Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn
145 150 155 160
Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu
165 170 175
Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly
180 185 190
Gln Asn Pro Val Leu Asp Lys Ala
195 200
<210> 116
<211> 200
<212> PRT
<213> 无毒土耳其出血性肠炎病毒（Avirulent turkey hemorrhagic enteritisvirus）
<400> 116
Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr
1 5 10 15
Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val
20 25 30
Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys
35 40 45
Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly
50 55 60
Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn
65 70 75 80
Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln
85 90 95
Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu
100 105 110
Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys
115 120 125
Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly
130 135 140
Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn
145 150 155 160
Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu
165 170 175
Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly
180 185 190
Gln Asn Pro Val Leu Asp Lys Ala
195 200
<210> 117
<211> 200
<212> PRT
<213> 土耳其腺病毒 A（turkey adenovirus A）
<400> 117
Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr
1 5 10 15
Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val
20 25 30
Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys
35 40 45
Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly
50 55 60
Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn
65 70 75 80
Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln
85 90 95
Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu
100 105 110
Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys
115 120 125
Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly
130 135 140
Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn
145 150 155 160
Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu
165 170 175
Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly
180 185 190
Gln Asn Pro Val Leu Asp Lys Ala
195 200
<210> 118
<211> 193
<212> PRT
<213> 蛙腺病毒1（frog adenovirus 1）
<400> 118
Met Glu Ala Glu Pro Ser Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr
1 5 10 15
Gly Arg Val Val Gly Ala Ser Gln Asn Phe Gly Ala Arg Ile Asn Thr
20 25 30
Leu His Ala Ser Pro Gln Leu Trp Ala Arg Met Gln Gln Val Gln Arg
35 40 45
Arg Arg Asn Glu Thr Val Thr Leu Ser Ala Leu Gln Gly Ser Gly Leu
50 55 60
Val Pro Ala Thr Pro Ser Ala Phe Gln Thr Thr Asp Ser Ser Asn Cys
65 70 75 80
Phe Leu Gly Gly Ser Asp Asn Trp Lys Glu Leu Leu Glu Pro Val Pro
85 90 95
Glu Ser Glu Glu Asn Pro Asn Gln Ala Leu Gln Asp Leu Leu Leu Ala
100 105 110
Ala Glu Ser Glu Lys Asp Gln Arg Asn Arg Asn Leu Thr Gln Ser Gln
115 120 125
Phe Val Ser Asp Phe Pro Pro Val Val Tyr Glu Arg Pro Phe Thr Gly
130 135 140
Ser Asp Phe Pro Leu Glu Phe Ser Pro Leu Tyr Ser Pro Asp Gly Asn
145 150 155 160
Gln Phe Thr Asn Thr Gly Trp Ile Ser Gln Ser Phe Pro Pro Asn Gln
165 170 175
Ser Phe Pro Glu Ile Ile Asn His Pro Thr Gln His Ser Ser Thr Thr
180 185 190
Ile
<210> 119
<211> 221
<212> PRT
<213> 猪腺病毒4（Porcine adenovirus 4）
<400> 119
Met Pro Leu Ala Lys Glu Ile Pro Thr Pro Tyr Val Trp Ser Tyr Gln
1 5 10 15
Pro Gln Met Gly Val Pro Ala Gly Ala Ser Gln Asp Tyr Ser Thr Lys
20 25 30
Ile Asn Cys Leu Ser Ala Gly Pro Arg Met Ala Gln Thr Val Phe Ala
35 40 45
Leu Arg Asp Gln Arg Asn Arg Val Leu Thr Ala Glu Ala His Gly Gln
50 55 60
Thr Pro Arg Pro Val Val Asn Pro Ala Ser Trp Pro Ala Ala Ala Leu
65 70 75 80
Ser His Glu Pro Pro Pro Pro Thr Leu Leu Thr Leu Pro Arg Asn Glu
85 90 95
Pro Thr Glu His Ala Met Thr Asp Ala Gly Tyr Gln Ile Ala Gly Gly
100 105 110
Ala Ala Pro Trp Ser Gly Val Lys Thr Gly Ser Phe Cys Gly Arg Gly
115 120 125
Leu Gln Leu Ala Glu Pro Pro Thr Thr Ala Ile Tyr Pro Ser Gly Leu
130 135 140
Phe His Leu Gly Arg Gly Gln Arg Leu Val Leu Asp His Gln Pro Ala
145 150 155 160
Arg Thr Leu Leu Leu Glu Ser Ala Pro Ser Val Pro Arg Tyr Gly Gly
165 170 175
Ile Gly Ala Arg Gln Phe Leu Lys Glu Phe Thr Pro Ala Val Tyr Pro
180 185 190
Gln Pro Tyr Ser Gly Pro Pro Asn Thr Phe Pro Asp Tyr Phe Cys Phe
195 200 205
Asn Tyr Asp Ser Val Ser Asn Ser Val Asp Gly Tyr Ser
210 215 220
<210> 120
<211> 198
<212> PRT
<213> 牛腺病毒10（Bovine adenovirus 10）
<400> 120
Met Ser Lys Glu Ile Pro Thr Pro Tyr Val Trp Asn Tyr Gln Pro Gln
1 5 10 15
Ala Gly Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Leu His
20 25 30
Trp Leu Ser Ala Gly Lys Ser Met Ile Ser Lys Val Asn Thr Ile Cys
35 40 45
Glu Asn Arg Asn Ser Ile Leu Leu Ser Lys Gly Met Gln Gln Leu Ala
50 55 60
Arg Leu Asn Ala Asn Pro Pro Phe Thr Asn Arg Ser Gln Ser Val Thr
65 70 75 80
Ala Leu Lys Leu Pro Arg Tyr Glu Ile Leu Glu Gln Arg Met Ser Asn
85 90 95
Ser Gly Met Gln Leu Ala Gly Gly Ser Leu Ser Leu Ala Glu Pro Leu
100 105 110
Cys Lys Gln Pro Leu Ala Pro Asp Gly Ser Phe Gln Leu Gly Gly Gly
115 120 125
Ala Lys Val Phe Ser Arg Gly Ala Thr Asn Tyr Ala Ile Arg Lys Thr
130 135 140
Ile Leu Leu Leu Glu Tyr Ser Gly Gly Met Gly Glu Lys Gln Phe Val
145 150 155 160
Lys Glu Phe Val Pro Ala Val Tyr Phe Asn Pro Tyr Ser Gly Leu Pro
165 170 175
Ala Ser Tyr Pro Asp Gln Phe Ile Ser Asn Tyr Asp Ala Val Thr Asp
180 185 190
Ser Val Asp Gly Tyr Ala
195
<210> 121
<211> 216
<212> PRT
<213> 牛腺病毒3（Bovine adenovirus 3）
<400> 121
Met Ser Lys Glu Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln
1 5 10 15
Met Gly Ala Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Phe Ser Ala Gly Pro Asp Met Ile His Asp Val Asn Asn Ile Arg
35 40 45
Asp Ala Gln Asn Arg Ile Leu Met Thr Gln Ser Ala Ile Thr Ala Thr
50 55 60
Pro Arg Asn Leu Ile Asp Pro Arg Gln Trp Ala Ala His Leu Ile Lys
65 70 75 80
Gln Pro Val Val Gly Thr Thr His Val Glu Met Pro Arg Asn Glu Val
85 90 95
Leu Glu Gln His Leu Thr Ser His Gly Ala Gln Ile Ala Gly Gly Gly
100 105 110
Ala Ala Gly Asp Tyr Phe Lys Ser Pro Thr Ser Ala Arg Thr Leu Ile
115 120 125
Pro Leu Thr Ala Ser Cys Leu Arg Pro Asp Gly Val Phe Gln Leu Gly
130 135 140
Gly Gly Ser Arg Ser Ser Phe Asn Pro Leu Gln Thr Asp Phe Ala Phe
145 150 155 160
His Ala Leu Pro Ser Arg Pro Arg His Gly Gly Ile Gly Ser Arg Gln
165 170 175
Phe Val Glu Glu Phe Val Pro Ala Val Tyr Leu Asn Pro Tyr Ser Gly
180 185 190
Pro Pro Asp Ser Tyr Pro Asp Gln Phe Ile Arg His Tyr Asn Val Tyr
195 200 205
Ser Asn Ser Val Ser Gly Tyr Ser
210 215
<210> 122
<211> 227
<212> PRT
<213> 树鼩腺病毒（Tree shrew adenovirus）
<400> 122
Met Ser Lys Asp Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln
1 5 10 15
Met Gly Val Ala Ala Gly Ala Ser Gln Asp Tyr Gly Thr Lys Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ser Met Ile His Arg Val Asn Asn Ile Arg
35 40 45
Glu Ala Arg Asn Arg Ile Leu Leu Arg Gln Ala Ala Leu Thr Glu Thr
50 55 60
Pro Arg Ala Val Met Asn Pro Pro Asn Trp Pro Ser Thr Leu Leu Tyr
65 70 75 80
His Asp Val Ala Pro Pro Thr Ser Val Pro Leu Pro Arg Asn Glu Arg
85 90 95
Leu Glu Ile Ala Met Thr Asn His Gly Ala Gln Leu Ala Gly Gly Gly
100 105 110
His Thr Ser Leu Pro Glu Gly Leu Lys Arg Glu Leu Leu Phe Gly Ser
115 120 125
Gly Ile Gln Leu Asn Glu Gln Leu Pro Val Arg Pro Tyr Gly Ala Ala
130 135 140
Val Arg Ala Asp Gly Thr Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser
145 150 155 160
Phe Asn Pro Arg Glu Glu Leu Phe Leu Lys Leu Gln Ser Ala Pro Ser
165 170 175
Gln Pro Arg Ser Gly Gly Ile Gly Ser Trp Gln Phe Val Glu Glu Phe
180 185 190
Val Pro Ala Val Tyr Tyr Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr
195 200 205
Pro Asp Gln Phe Ile Ser Asn Tyr Asp Val Val Ser Asp Ser Val Asp
210 215 220
Gly Tyr Asp
225
<210> 123
<211> 221
<212> PRT
<213> 牛腺病毒1（Bovine adenovirus 1）
<400> 123
Met Ser Lys Asp Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln
1 5 10 15
Leu Gly Gly Cys Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn Trp
20 25 30
Leu Ser Ala Gly Pro Ser Met Ile Asn Gln Val Asn Ser Val Arg Ala
35 40 45
Asp Arg Asn Arg Ile Leu Leu Arg Gln Ala Ala Val Ser Glu Thr Pro
50 55 60
Arg Leu Val Arg Asn Pro Pro Thr Trp Pro Ala Gln Tyr Leu Phe Gln
65 70 75 80
Pro Ile Gly Ala Pro Gln Thr Phe Glu Leu Pro Arg Asn Glu Ser Leu
85 90 95
Glu Val Ala Met Ser Asn Ser Gly Met Gln Leu Ala Gly Gly Gly Arg
100 105 110
Arg Thr Lys Asp Ile Lys Pro Glu Asp Ile Val Gly Arg Gly Leu Glu
115 120 125
Leu Asn Ser Asp Ile Pro Ser Ala Ser Phe Leu Arg Pro Asp Gly Val
130 135 140
Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser Phe Asn Pro Gly Leu Ser
145 150 155 160
Thr Leu Leu Thr Val Gln Pro Ala Ser Ser Leu Pro Arg Ser Gly Gly
165 170 175
Ile Gly Glu Val Gln Phe Val His Glu Phe Val Pro Ser Val Tyr Phe
180 185 190
Gln Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Glu Phe Ile Tyr
195 200 205
Asn Tyr Asp Ile Val Ser Asp Ser Val Asp Gly Tyr Asp
210 215 220
<210> 124
<211> 223
<212> PRT
<213> 绵羊腺病毒A（Ovine adenovirus A）
<400> 124
Met Ser Lys Glu Ile Pro Thr Pro His Met Trp Thr Phe Gln Pro Gln
1 5 10 15
Leu Gly Gln Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ser Met Ile Ser Gln Val Asp Ser Ile Arg
35 40 45
Ala Glu Arg Asn Arg Ile Leu Leu His Gln Ala Ala Val Ser Ala Thr
50 55 60
Pro Arg Ala Ile Met Asn Pro Pro Ala Trp Pro Ala Ser Arg Leu Phe
65 70 75 80
Gln Pro Val Asp Thr Val Gln Thr Leu Glu Leu Pro Arg Asn Glu Leu
85 90 95
Leu Glu Thr Ala Met Thr Asn Ser Gly Met Gln Leu Ala Gly Gly Gly
100 105 110
Val His Arg Thr Lys Asp Ile Lys Pro Glu Asp Leu Val Gly Arg Gly
115 120 125
Ile Gln Leu Asn Ser Tyr Gln Pro Pro Thr Thr Arg Leu Lys Pro Glu
130 135 140
Arg Val Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser Phe Asn Pro Ser
145 150 155 160
Ile Asn Thr Leu Leu Thr Leu Gln Pro Ala Ala Ser Val Pro Arg Ser
165 170 175
Gly Gly Ile Gly Glu Val Gln Phe Val His Glu Phe Val Pro Ser Val
180 185 190
Tyr Phe Gln Pro Phe Ser Gly Pro Pro Gly Ser Tyr Pro Asp Glu Phe
195 200 205
Ile Tyr Asn Phe Asp Val Ala Thr Asp Ser Ile Asp Gly Tyr Ala
210 215 220
<210> 125
<211> 224
<212> PRT
<213> 犬腺病毒2（Canine adenovirus 2）
<400> 125
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Thr Gly His Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Gln Met Asn
20 25 30
Trp Phe Ser Ala Gly Pro Ser Met Ile Ser Gln Val Tyr Gly Ile Arg
35 40 45
Asp Leu Arg Asn Lys Val Leu Ile Thr Gln Ala Glu Ile Thr Lys Thr
50 55 60
Pro Arg Thr Ile Met Asp Pro Pro Ile Trp Pro Ala Ala Met Leu Val
65 70 75 80
Gln Glu Ala Ala Pro Pro Lys Thr Val Thr Leu Pro Arg Asn His Thr
85 90 95
Leu Glu Gln Ala Met Thr Asn Ser Gly Ala Gln Leu Ala Gly Gly Arg
100 105 110
Gln Leu Cys Pro Ser Gln Ile Gly Ile Lys Ser Pro Val Leu Ala Gly
115 120 125
Thr Gly Ile Gln Leu Ser Glu Asp Ile Pro Ser Ala Ser Trp Ile Arg
130 135 140
Pro Asp Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Ser
145 150 155 160
Pro Thr Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Thr Pro Arg
165 170 175
Ala Gly Gly Val Gly Thr Tyr Gln Phe Val Arg Glu Phe Val Pro Glu
180 185 190
Val Tyr Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln
195 200 205
Phe Ile Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp
210 215 220
<210> 126
<211> 224
<212> PRT
<213> 犬腺病毒1（Canine adenovirus 1）
<400> 126
Met Ser Lys Glu Ile Pro Thr Pro Tyr Ile Trp Ser Tyr Gln Pro Gln
1 5 10 15
Thr Gly His Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Gln Met Asn
20 25 30
Trp Phe Ser Ala Gly Pro Ser Met Ile Ser His Val Tyr Gly Ile Arg
35 40 45
Asp Leu Arg Asn Lys Val Leu Met Thr Gln Ala Gln Ile Thr Lys Thr
50 55 60
Pro Arg Thr Ile Met Asp Pro Pro Ile Trp Pro Ala Ser Met Leu Val
65 70 75 80
Gln Lys His Ala Thr Pro Lys Thr Ile Ala Leu Pro Arg Asn His Thr
85 90 95
Leu Glu Gln Ala Met Val Asn Cys Gly Ala Gln Leu Ala Gly Gly Arg
100 105 110
Gln Pro Ser Pro Ser His Ile Asp Ile Lys Asp Thr Met Leu Ala Gly
115 120 125
Thr Gly Ile Gln Leu Gly Glu Asp Ile Pro Ser Val Ser Trp Ile Arg
130 135 140
Pro Asp Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Ser
145 150 155 160
Pro Thr Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Thr Pro Arg
165 170 175
Thr Gly Gly Val Gly Ser Tyr Gln Phe Val Arg Glu Phe Val Pro Glu
180 185 190
Val Tyr Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln
195 200 205
Phe Ile Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp
210 215 220
<210> 127
<211> 222
<212> PRT
<213> 蝙蝠腺病毒 TJM（Bat adenovirus TJM）
<400> 127
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Phe Gln Pro Gln
1 5 10 15
Ser Gly His Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Gln Met Asn
20 25 30
Trp Phe Ser Ala Gly Pro Ser Met Ile Asn Gln Val Tyr Gln Ile Arg
35 40 45
Asp Leu Arg Asn Arg Ile Leu Thr Thr Gln Ala Gln Ile Thr Glu Thr
50 55 60
Pro Arg Glu Val Met Asn Pro Pro Val Trp Pro Ala Ala Thr Ile Val
65 70 75 80
Gln Glu Ala Pro Pro Pro Thr Thr Val Ala Leu Pro Arg Asn His Ala
85 90 95
Leu Glu Thr Ala Met Thr Asn Ser Gly Ile Gln Leu Ala Gly Gly Arg
100 105 110
Cys Leu Leu Pro Ala Ala Arg Ala Ala Cys Pro Ile Lys Gly Arg Gly
115 120 125
Leu Gln Leu Ser Glu Asp Ile Pro Ser Ala Ser Trp Ile Arg Pro Asp
130 135 140
Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Asn Pro Thr
145 150 155 160
Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Gln Pro Arg Ala Gly
165 170 175
Gly Ile Gly Thr Val Gln Phe Val Arg Glu Phe Val Pro Glu Val Tyr
180 185 190
Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln Phe Ile
195 200 205
Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp
210 215 220
<210> 128
<211> 223
<212> PRT
<213> 猪腺病毒1（Porcine adenovirus 1）
<400> 128
Met Ser Lys Gln Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Ser Gly Arg Ala Ala Gly Ala Ser Val Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ser Met Ile Gly Gln Val Asn Asp Ile Arg
35 40 45
His Thr Arg Asn Gln Ile Leu Ile Arg Gln Ala Leu Ile Thr Glu Thr
50 55 60
Pro Arg Pro Val Gln Asn Pro Pro Ser Trp Pro Ala Arg Leu Leu Pro
65 70 75 80
Gln Met Thr Gln Pro Pro Thr His Leu His Leu Pro Arg Asn Glu Ile
85 90 95
Leu Glu Gly Arg Leu Thr Asp Ala Gly Met Gln Leu Ala Gly Gly Gly
100 105 110
Ala Leu Ala Pro Arg Asp Leu Tyr Ala Leu Thr Leu Arg Gly Arg Gly
115 120 125
Ile Gln Leu Asn Glu Asp Leu Pro Phe Ser Ala Ser Thr Leu Arg Pro
130 135 140
Asp Gly Ile Phe Gln Leu Gly Gly Gly Gly Arg Ser Ser Phe Asn Pro
145 150 155 160
Thr Asp Ala Tyr Leu Thr Leu Gln Asn Ser Ser Ser Leu Pro Arg Ser
165 170 175
Gly Gly Ile Gly Ser Asp Gln Phe Val Arg Glu Phe Val Pro Thr Val
180 185 190
Tyr Ile Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Gln Phe
195 200 205
Ile Ala Asn Tyr Asn Ile Leu Thr Asp Ser Val Ala Gly Tyr Asp
210 215 220
<210> 129
<211> 223
<212> PRT
<213> 猪腺病毒3（Porcine adenovirus 3）
<400> 129
Met Ser Lys Gln Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Ser Gly Arg Ala Ala Gly Ala Ser Val Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ser Met Ile Gly Gln Val Asn Asp Ile Arg
35 40 45
His Thr Arg Asn Gln Ile Leu Ile Arg Gln Ala Leu Ile Thr Glu Thr
50 55 60
Pro Arg Pro Val Gln Asn Pro Pro Ser Trp Pro Ala Ser Leu Leu Pro
65 70 75 80
Gln Met Thr Gln Pro Pro Thr His Leu His Leu Pro Arg Asn Glu Ile
85 90 95
Leu Glu Gly Arg Leu Thr Asp Ala Gly Met Gln Leu Ala Gly Gly Gly
100 105 110
Ala Leu Ala Pro Arg Asp Leu Tyr Ala Leu Thr Leu Arg Gly Arg Gly
115 120 125
Ile Gln Leu Asn Glu Asp Leu Pro Leu Ser Ala Ser Thr Leu Arg Pro
130 135 140
Asp Gly Ile Phe Gln Leu Gly Gly Gly Gly Arg Ser Ser Phe Asn Pro
145 150 155 160
Thr Asp Ala Tyr Leu Thr Leu Gln Asn Ser Ser Ser Leu Pro Arg Ser
165 170 175
Gly Gly Ile Gly Ser Glu Gln Phe Val Arg Glu Phe Val Pro Thr Val
180 185 190
Tyr Ile Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Gln Phe
195 200 205
Ile Ala Asn Tyr Asn Ile Leu Thr Asp Ser Val Ala Gly Tyr Asp
210 215 220
<210> 130
<211> 227
<212> PRT
<213> 猴腺病毒22（Simian adenovirus 22）
<400> 130
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg
35 40 45
Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr
50 55 60
Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr
65 70 75 80
Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln
85 90 95
Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala
100 105 110
Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile
115 120 125
Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu
130 135 140
Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser
145 150 155 160
Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser
165 170 175
Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe
180 185 190
Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr
195 200 205
Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp
210 215 220
Gly Tyr Asp
225
<210> 131
<211> 227
<212> PRT
<213> 猴腺病毒23（Simian adenovirus 23）
<400> 131
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg
35 40 45
Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr
50 55 60
Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr
65 70 75 80
Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln
85 90 95
Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala
100 105 110
Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile
115 120 125
Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu
130 135 140
Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser
145 150 155 160
Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser
165 170 175
Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe
180 185 190
Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr
195 200 205
Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp
210 215 220
Gly Tyr Asp
225
<210> 132
<211> 227
<212> PRT
<213> 猴腺病毒24（Simian adenovirus 24）
<400> 132
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg
35 40 45
Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr
50 55 60
Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr
65 70 75 80
Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln
85 90 95
Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala
100 105 110
Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile
115 120 125
Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu
130 135 140
Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser
145 150 155 160
Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser
165 170 175
Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe
180 185 190
Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr
195 200 205
Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp
210 215 220
Gly Tyr Asp
225
<210> 133
<211> 233
<212> PRT
<213> 猴腺病毒1（Simian adenovirus 1）
<400> 133
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Ser Lys Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg
35 40 45
Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ala Ala Ile Thr Ala Thr
50 55 60
Pro Arg Arg Gln Leu Asn Pro Pro Ser Trp Pro Ala Ala Gln Val Tyr
65 70 75 80
Gln Glu Asn Pro Arg Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Glu
85 90 95
Ala Glu Val Leu Met Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ser
100 105 110
Arg Tyr Ala Arg Tyr Arg Gly Arg Ala Ala Pro Tyr Ser Pro Gly Ser
115 120 125
Ile Lys Arg Val Ile Ile Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu
130 135 140
Thr Val Ser Ser Ser Thr Gly Leu Arg Pro Asp Gly Val Phe Gln Leu
145 150 155 160
Gly Gly Ala Gly Arg Ser Ser Phe Thr Thr Arg Gln Ala Tyr Leu Thr
165 170 175
Leu Gln Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu
180 185 190
Gln Phe Val Glu Glu Phe Val Pro Ser Val Tyr Phe Asn Pro Phe Ser
195 200 205
Gly Ser Pro Gly Arg Tyr Pro Asp Ala Phe Ile Pro Asn Phe Asp Ala
210 215 220
Val Ser Glu Ser Val Asp Gly Tyr Asp
225 230
<210> 134
<211> 233
<212> PRT
<213> 猴腺病毒7（Simian adenovirus 7）
<400> 134
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Ser Lys Met Asn
20 25 30
Trp Leu Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg
35 40 45
Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ala Ala Ile Thr Ala Thr
50 55 60
Pro Arg Arg Gln Leu Asn Pro Pro Ser Trp Pro Ala Ala Gln Val Tyr
65 70 75 80
Gln Glu Thr Pro Arg Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Glu
85 90 95
Ala Glu Val Leu Met Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ser
100 105 110
Arg Tyr Ala Arg Tyr Arg Gly Arg Ala Ala Pro Tyr Ser Pro Gly Ser
115 120 125
Ile Lys Arg Val Ile Ile Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu
130 135 140
Ala Val Ser Ser Ser Thr Gly Leu Arg Pro Asp Gly Val Phe Gln Leu
145 150 155 160
Gly Gly Ala Gly Arg Ser Ser Phe Thr Thr Arg Gln Ala Tyr Leu Thr
165 170 175
Leu Gln Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu
180 185 190
Gln Phe Val Glu Glu Phe Val Pro Ser Val Tyr Phe Asn Pro Phe Ser
195 200 205
Gly Ser Pro Gly Arg Tyr Pro Asp Ala Phe Ile Pro Asn Phe Asp Ala
210 215 220
Val Ser Glu Ser Val Asp Gly Tyr Asp
225 230
<210> 135
<211> 227
<212> PRT
<213> 人腺病毒5（Human adenovirus 5）
<400> 135
Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln
1 5 10 15
Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Ile Asn
20 25 30
Tyr Met Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg
35 40 45
Ala His Arg Asn Arg Ile Leu Leu Glu Gln Ala Ala Ile Thr Thr Thr
50 55 60
Pro Arg Asn Asn Leu Asn Pro Arg Ser Trp Pro Ala Ala Leu Val Tyr
65 70 75 80
Gln Glu Ser Pro Ala Pro Thr Thr Val Val Leu Pro Arg Asp Ala Gln
85 90 95
Ala Glu Val Gln Met Thr Asn Ser Gly Ala Gln Leu Ala Gly Gly Phe
100 105 110
Arg His Arg Val Arg Ser Pro Gly Gln Gly Ile Thr His Leu Thr Ile
115 120 125
Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu Ser Val Ser Ser Ser Leu
130 135 140
Gly Leu Arg Pro Asp Gly Thr Phe Gln Ile Gly Gly Ala Gly Arg Pro
145 150 155 160
Ser Phe Thr Pro Arg Gln Ala Ile Leu Thr Leu Gln Thr Ser Ser Ser
165 170 175
Glu Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Ile Glu Glu Phe
180 185 190
Val Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Pro Pro Gly His Tyr
195 200 205
Pro Asp Gln Phe Ile Pro Asn Phe Asp Ala Val Lys Asp Ser Ala Asp
210 215 220
Gly Tyr Asp
225
<210> 136
<211> 951
<212> PRT
<213> 人腺病毒5（Human adenovirus 5）
<400> 136
Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser
1 5 10 15
Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala
20 25 30
Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro
35 40 45
Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu
50 55 60
Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr
65 70 75 80
Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met
85 90 95
Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr
100 105 110
Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly
115 120 125
Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile
130 135 140
Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln
145 150 155 160
Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly
165 170 175
Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr
180 185 190
Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu
195 200 205
Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu
210 215 220
Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro
225 230 235 240
Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly
245 250 255
Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala
260 265 270
Ala Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser
275 280 285
Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro
290 295 300
Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met
305 310 315 320
Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu
325 330 335
Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala
340 345 350
Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu
355 360 365
Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe
370 375 380
Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile
385 390 395 400
Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro
405 410 415
Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys
420 425 430
Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp
435 440 445
Lys Asn Glu Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu
450 455 460
Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr
465 470 475 480
Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp Asn
485 490 495
Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu
500 505 510
Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met
515 520 525
Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr
530 535 540
Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln
545 550 555 560
Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly
565 570 575
Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu
580 585 590
Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys
595 600 605
Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn
610 615 620
Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln
625 630 635 640
Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro
645 650 655
Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala
660 665 670
Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro
675 680 685
Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser Ile
690 695 700
Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val
705 710 715 720
Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu
725 730 735
Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly
740 745 750
Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln
755 760 765
Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu
770 775 780
Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met
785 790 795 800
Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln Val
805 810 815
Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala
820 825 830
Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro
835 840 845
Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe Leu
850 855 860
Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser
865 870 875 880
Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser
885 890 895
Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro
900 905 910
Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val His
915 920 925
Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe
930 935 940
Ser Ala Gly Asn Ala Thr Thr
945 950
<210> 137
<211> 35938
<212> DNA
<213> 人腺病毒5（Human adenovirus 5）
<400> 137
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60
ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120
gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180
gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240
taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300
agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360
gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420
cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480
tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540
tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600
aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660
tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720
cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780
gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840
cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900
ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960
cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020
caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080
ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140
tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200
gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260
ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320
cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380
ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440
gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500
cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560
ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620
gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680
cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740
ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800
tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860
gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920
caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980
gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040
agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100
aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160
cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220
gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280
gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340
gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400
gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460
tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520
ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580
tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640
agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700
tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760
gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820
acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880
gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940
aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000
ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060
gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120
tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180
acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240
aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300
tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360
gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420
tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480
ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540
tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600
ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660
gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720
ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780
agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840
actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900
acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960
ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020
atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt 4080
cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt 4140
cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat 4200
acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg 4260
gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt 4320
ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt 4380
taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt 4440
tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag 4500
tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact 4560
tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg 4620
gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt 4680
ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg 4740
gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg 4800
ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg 4860
gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc 4920
cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc 4980
tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt 5040
ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag 5100
caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa 5160
gcagttccag gcggtcccac agctcggtca cctgctctac ggcatctcga tccagcatat 5220
ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag 5280
acgggccagg gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac 5340
ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct 5400
ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt 5460
gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc 5520
gccgcacgag gggcagtgca gacttttgag ggcgtagagc ttgggcgcga gaaataccga 5580
ttccggggag taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca 5640
ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt 5700
cttacctctg gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc 5760
cccgtataca gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag 5820
aaactcggac cactctgaga caaaggctcg cgtccaggcc agcacgaagg aggctaagtg 5880
ggaggggtag cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat 5940
gtcgccctct tcggcatcaa ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg 6000
tgttcctgaa ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc 6060
atcgctgtct gcgagggcca gctgttgggg tgagtactcc ctctgaaaag cgggcatgac 6120
ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc 6180
ggtgatgcct ttgagggtgg ccgcatccat ctggtcagaa aagacaatct ttttgttgtc 6240
aagcttggtg gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag 6300
ggtttggttt ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc 6360
gcgcgcaacg caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac 6420
gcgccaaccg cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag 6480
gcgctcgttg gtccagcaga ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc 6540
tagctgcgtc tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc 6600
gtcgaagtag tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc 6660
aagcgcgcgc tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga 6720
ggcgtacatg ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt 6780
agggtagcat cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg 6840
agcgaggagg tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg 6900
cctgaagatg gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc 6960
gtctgtgaga cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac 7020
cagctcggcg gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc 7080
atacttatcc tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc 7140
tttccagtac tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta 7200
gaactggttg acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg 7260
cgcggccttc cggagcgagg tgtgggtgag cgcaaaggtg tccctgacca tgactttgag 7320
gtactggtat ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt 7380
gcgctttttg gaacgcggat ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc 7440
cgcgcgaggc ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt 7500
aattacctgg gcggcgagca cgatctcgtc aaagccgttg atgttgtggc ccacaatgta 7560
aagttccaag aagcgcggga tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt 7620
gagctcttca ggggagctga gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt 7680
ggaagcgacg aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa 7740
ggtcctaaac tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg 7800
gtcttgttcc cagcggtccc atccaaggtt cgcggctagg tctcgcgcgg cagtcactag 7860
aggctcatct ccgccgaact tcatgaccag catgaagggc acgagctgct tcccaaaggc 7920
ccccatccaa gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg 7980
cgagccgatc gggaagaact ggatctcccg ccaccaattg gaggagtggc tattgatgtg 8040
gtgaaagtag aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc 8100
gcagtactgg cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg 8160
cacaaggaag cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc 8220
tacttcggct gcttgtcctt gaccgtctgg ctgctcgagg ggagttacgg tggatcggac 8280
caccacgccg cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac 8340
aacatcgcgc agatgggagc tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg 8400
gagctcctgc aggtttacct cgcatagacg ggtcagggcg cgggctagat ccaggtgata 8460
cctaatttcc aggggctggt tggtggcggc gtcgatggct tgcaagaggc cgcatccccg 8520
cggcgcgact acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc 8580
atctaaaagc ggtgacgcgg gcgagccccc ggaggtaggg ggggctccgg acccgccggg 8640
agagggggca ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg 8700
ttgctggcga acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag 8760
acgacgggcc cggtgagctt gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg 8820
ttgacggcgg cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatc 8880
tcggccatga actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg 8940
gtggcggcga ggtcgttgga aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc 9000
tcgttccaga cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc 9060
tgcgcgagat tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag 9120
aggtagttga gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc 9180
aacgtggatt cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc 9240
acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga 9300
cggatgagct cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct 9360
tcttcttcaa tctcctcttc cataagggcc tccccttctt cttcttctgg cggcggtggg 9420
ggagggggga cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc 9480
atctccccgc ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc 9540
agttggaaga cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccatgcggc 9600
agggatacgg cgctaacgat gcatctcaac aattgttgtg taggtactcc gccgccgagg 9660
gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag 9720
tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg 9780
tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg 9840
gtcgacagaa gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg 9900
ccccaggctt cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct 9960
accggcactt cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg 10020
gcggcggagt ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc 10080
ctcatcggct gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc 10140
acctgcgtga gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg 10200
ttgatggtgt aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc 10260
gagagctcgg tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa 10320
gtccgcacca ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc 10380
cagcgtaggg tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg 10440
tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg 10500
cggacgcggt tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg 10560
ccggtcaggc gcgcgcaatc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg 10620
ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 10680
tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 10740
caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 10800
gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 10860
gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc 10920
gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 10980
ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 11040
ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 11100
caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 11160
acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 11220
cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 11280
cggtacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac 11340
ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca 11400
gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 11460
cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 11520
accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac 11580
gtgcgtacgc ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt 11640
gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata 11700
gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc 11760
gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc 11820
agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag 11880
ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc 11940
gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt 12000
tatcgcaacg agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac 12060
cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag 12120
gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg 12180
gaggcagctg gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc 12240
ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg 12300
gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc 12360
agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca 12420
tgtcgctgac tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct 12480
ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg 12540
cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct 12600
acgacgcgct gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg 12660
accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg 12720
gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc 12780
cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga 12840
caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag 12900
gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc 12960
gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt 13020
tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag 13080
gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt 13140
tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg 13200
caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa 13260
acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc 13320
gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca 13380
tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg 13440
ccgtgaaccc cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg 13500
gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca 13560
tagacgacag cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc 13620
aggcagaggc ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag 13680
gcgctgcggc cccgcggtca gatgctagta gcccatttcc aagcttgata gggtctctta 13740
ccagcactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc 13800
tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga 13860
gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcacagg gacgtgccag 13920
gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg 13980
acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg 14040
cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata 14100
aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg 14160
gcgcgcggcg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc 14220
gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc 14280
tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agttggcacc 14340
cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct 14400
gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag 14460
cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga 14520
cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa 14580
gtttaaggcg cgggtgatgg tgtcgcgctt gcctactaag gacaatcagg tggagctgaa 14640
atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga 14700
ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct 14760
ggaaagcgac atcggggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt 14820
cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt 14880
gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg 14940
caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa 15000
cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca 15060
gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa 15120
cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga 15180
cacctttgcc acacgggctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc 15240
cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct 15300
gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca 15360
gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg 15420
gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtcgttgcc 15480
agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt 15540
ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 15600
ctcccaactc atccgccagt ttacctctct gacccacgtg ttcaatcgct ttcccgagaa 15660
ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc 15720
tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac 15780
cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc 15840
gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag 15900
caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg 15960
ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa 16020
acgcggccgc actgggcgca ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc 16080
gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt 16140
ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg 16200
ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc 16260
acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt 16320
cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc 16380
tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg 16440
cgtgcccgtg cgcacccgcc ccccgcgcaa ctagattgca agaaaaaact acttagactc 16500
gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat 16560
caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga 16620
gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga 16680
tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg 16740
gaaaggtcga cgcgtaaaac gtgttttgcg acccggcacc accgtagtct ttacgcccgg 16800
tgagcgctcc acccgcacct acaagcgcgt gtatgatgag gtgtacggcg acgaggacct 16860
gcttgagcag gccaacgagc gcctcgggga gtttgcctac ggaaagcggc ataaggacat 16920
gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca 16980
gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg 17040
tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt 17100
ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca 17160
ggtggcgccg ggactgggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac 17220
cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt 17280
ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca 17340
aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta 17400
cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc 17460
cggctatcgt ggctacacct accgccccag aagacgagca actacccgac gccgaaccac 17520
cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg 17580
cagggtggct cgcgaaggag gcaggaccct ggtgctgcca acagcgcgct accaccccag 17640
catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg 17700
tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg 17760
cctgacgggc ggcatgcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat 17820
gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc 17880
cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg 17940
gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta 18000
gaatggaaga catcaacttt gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg 18060
gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc 18120
tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga 18180
acagcagcac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg 18240
tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc 18300
aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg 18360
tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa 18420
ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caaggcctgc 18480
ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa 18540
cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg 18600
ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat 18660
cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg 18720
gggtgcaatc cctgaagcgc cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc 18780
atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa 18840
gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc 18900
ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag 18960
cctgaataac aagtttagaa accccacggt ggcgcctacg cacgacgtga ccacagaccg 19020
gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta 19080
caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg ctggacatgg cttccacgta 19140
ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc 19200
ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac 19260
tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca 19320
agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac 19380
aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt 19440
tcaacctgaa cctcaaatag gagaatctca gtggtacgaa actgaaatta atcatgcagc 19500
tgggagagtc cttaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc 19560
cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag 19620
tcaagtggaa atgcaatttt tctcaactac tgaggcgacc gcaggcaatg gtgataactt 19680
gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat 19740
ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat 19800
gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa 19860
cagcacgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga 19920
tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag 19980
aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat 20040
tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt 20100
gattaataca gagactctta ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga 20160
aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat 20220
ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta 20280
tttgcccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac 20340
ctacgactac atgaacaagc gagtggtggc tcccgggtta gtggactgct acattaacct 20400
tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa 20460
tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat 20520
ccaggtgcct cagaagttct ttgccattaa aaacctcctt ctcctgccgg gctcatacac 20580
ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga 20640
cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt 20700
ccccatggcc cacaacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga 20760
ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc 20820
taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt 20880
cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac 20940
ctactctggc tctataccct acctagatgg aaccttttac ctcaaccaca cctttaagaa 21000
ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc 21060
caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa 21120
catgaccaaa gactggttcc tggtacaaat gctagctaac tacaacattg gctaccaggg 21180
cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc 21240
catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct 21300
acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca 21360
ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac 21420
ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat 21480
gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc 21540
gctagacatg acttttgagg tggatcccat ggacgagccc acccttcttt atgttttgtt 21600
tgaagtcttt gacgtggtcc gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta 21660
cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca 21720
acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt 21780
tgtgggccat attttttggg cacctatgac aagcgctttc caggctttgt ttctccacac 21840
aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctgggggcgt acactggatg 21900
gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct 21960
gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc 22020
attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg 22080
cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg 22140
ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc 22200
atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc 22260
ttcctggagc gccactcgcc ctacttccgc agccacagtg cgcagattag gagcgccact 22320
tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc 22380
aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc 22440
gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg 22500
cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg 22560
aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat 22620
atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacagggttg 22680
cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag 22740
atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc 22800
tgccttccca aaaagggcgc gtgcccaggc tttgagttgc actcgcaccg tagtggcatc 22860
aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc 22920
tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg 22980
gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag 23040
atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc 23100
ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt caatcacgtg ctccttattt 23160
atcataatgc ttccgtgtag acacttaagc tcgccttcga tctcagcgca gcggtgcagc 23220
cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg 23280
tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc 23340
tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact 23400
tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc 23460
agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg 23520
ttcatcaccg taatttcact ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc 23580
ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg 23640
ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatcttct 23700
ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttgggagaa 23760
gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc 23820
gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg 23880
atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg 23940
gacgacacgt cctccatggt tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg 24000
gtttcgcgct gctcctcttc ccgactggcc atttccttct cctataggca gaaaaagatc 24060
atggagtcag tcgagaagaa ggacagccta accgccccct ctgagttcgc caccaccgcc 24120
tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag 24180
gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca 24240
gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc 24300
gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag 24360
catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgatgtgccc 24420
ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc 24480
cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta 24540
tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc 24600
ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct 24660
gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc 24720
gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct 24780
ggagtgttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc 24840
gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc 24900
atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa 24960
caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg 25020
cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc 25080
gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag 25140
gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac 25200
gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa 25260
aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt 25320
tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag 25380
gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa acttgaagga cctatggacg 25440
gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg 25500
cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt 25560
aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc 25620
gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt 25680
ctgcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac 25740
ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc 25800
aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg 25860
cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct 25920
taccttcgca aatttgtacc tgaggactac cacgcccacg agattaggtt ctacgaagac 25980
caatcccgcc cgccaaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt 26040
ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg 26100
gtttacttgg acccccagtc cggcgaggag ctcaacccaa tccccccgcc gccgcagccc 26160
tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct 26220
gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga 26280
cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt 26340
cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca 26400
gaaatcggca accggttcca gcatggctac aacctccgct cctcaggcgc cgccggcact 26460
gcccgttcgc cgacccaacc gtagatggga caccactgga accagggccg gtaagtccaa 26520
gcagccgccg ccgttagccc aagagcaaca acagcgccaa ggctaccgct catggcgcgg 26580
gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg 26640
ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg 26700
tcatctctac agcccatact gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca 26760
cacagaagca aaggcgaccg gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg 26820
cggcagcagc aggaggagga gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg 26880
agcttagaaa caggattttt cccactctgt atgctatatt tcaacagagc aggggccaag 26940
aacaagagct gaaaataaaa aacaggtctc tgcgatccct cacccgcagc tgcctgtatc 27000
acaaaagcga agatcagctt cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat 27060
actgcgcgct gactcttaag gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac 27120
tacgtcatct ccagcggcca cacccggcgc cagcacctgt cgtcagcgcc attatgagca 27180
aggaaattcc cacgccctac atgtggagtt accagccaca aatgggactt gcggctggag 27240
ctgcccaaga ctactcaacc cgaataaact acatgagcgc gggaccccac atgatatccc 27300
gggtcaacgg aatccgcgcc caccgaaacc gaattctctt ggaacaggcg gctattacca 27360
ccacacctcg taataacctt aatccccgta gttggcccgc tgccctggtg taccaggaaa 27420
gtcccgctcc caccactgtg gtacttccca gagacgccca ggccgaagtt cagatgacta 27480
actcaggggc gcagcttgcg ggcggctttc gtcacagggt gcggtcgccc gggcagggta 27540
taactcacct gacaatcaga gggcgaggta ttcagctcaa cgacgagtcg gtgagctcct 27600
cgcttggtct ccgtccggac gggacatttc agatcggcgg cgccggccgt ccttcattca 27660
cgcctcgtca ggcaatccta actctgcaga cctcgtcctc tgagccgcgc tctggaggca 27720
ttggaactct gcaatttatt gaggagtttg tgccatcggt ctactttaac cccttctcgg 27780
gacctcccgg ccactatccg gatcaattta ttcctaactt tgacgcggta aaggactcgg 27840
cggacggcta cgactgaatg ttaagtggag aggcagagca actgcgcctg aaacacctgg 27900
tccactgtcg ccgccacaag tgctttgccc gcgactccgg tgagttttgc tactttgaat 27960
tgcccgagga tcatatcgag ggcccggcgc acggcgtccg gcttaccgcc cagggagagc 28020
ttgcccgtag cctgattcgg gagtttaccc agcgccccct gctagttgag cgggacaggg 28080
gaccctgtgt tctcactgtg atttgcaact gtcctaacct tggattacat caagatcttt 28140
gttgccatct ctgtgctgag tataataaat acagaaatta aaatatactg gggctcctat 28200
cgccatcctg taaacgccac cgtcttcacc cgcccaagca aaccaaggcg aaccttacct 28260
ggtactttta acatctctcc ctctgtgatt tacaacagtt tcaacccaga cggagtgagt 28320
ctacgagaga acctctccga gctcagctac tccatcagaa aaaacaccac cctccttacc 28380
tgccgggaac gtacgagtgc gtcaccggcc gctgcaccac acctaccgcc tgaccgtaaa 28440
ccagactttt tccggacaga cctcaataac tctgtttacc agaacaggag gtgagcttag 28500
aaaaccctta gggtattagg ccaaaggcgc agctactgtg gggtttatga acaattcaag 28560
caactctacg ggctattcta attcaggttt ctctagaatc ggggttgggg ttattctctg 28620
tcttgtgatt ctctttattc ttatactaac gcttctctgc ctaaggctcg ccgcctgctg 28680
tgtgcacatt tgcatttatt gtcagctttt taaacgctgg ggtcgccacc caagatgatt 28740
aggtacataa tcctaggttt actcaccctt gcgtcagccc acggtaccac ccaaaaggtg 28800
gattttaagg agccagcctg taatgttaca ttcgcagctg aagctaatga gtgcaccact 28860
cttataaaat gcaccacaga acatgaaaag ctgcttattc gccacaaaaa caaaattggc 28920
aagtatgctg tttatgctat ttggcagcca ggtgacacta cagagtataa tgttacagtt 28980
ttccagggta aaagtcataa aacttttatg tatacttttc cattttatga aatgtgcgac 29040
attaccatgt acatgagcaa acagtataag ttgtggcccc cacaaaattg tgtggaaaac 29100
actggcactt tctgctgcac tgctatgcta attacagtgc tcgctttggt ctgtacccta 29160
ctctatatta aatacaaaag cagacgcagc tttattgagg aaaagaaaat gccttaattt 29220
actaagttac aaagctaatg tcaccactaa ctgctttact cgctgcttgc aaaacaaatt 29280
caaaaagtta gcattataat tagaatagga tttaaacccc ccggtcattt cctgctcaat 29340
accattcccc tgaacaattg actctatgtg ggatatgctc cagcgctaca accttgaagt 29400
caggcttcct ggatgtcagc atctgacttt ggccagcacc tgtcccgcgg atttgttcca 29460
gtccaactac agcgacccac cctaacagag atgaccaaca caaccaacgc ggccgccgct 29520
accggactta catctaccac aaatacaccc caagtttctg cctttgtcaa taactgggat 29580
aacttgggca tgtggtggtt ctccatagcg cttatgtttg tatgccttat tattatgtgg 29640
ctcatctgct gcctaaagcg caaacgcgcc cgaccaccca tctatagtcc catcattgtg 29700
ctacacccaa acaatgatgg aatccataga ttggacggac tgaaacacat gttcttttct 29760
cttacagtat gattaaatga gacatgattc ctcgagtttt tatattactg acccttgttg 29820
cgcttttttg tgcgtgctcc acattggctg cggtttctca catcgaagta gactgcattc 29880
cagccttcac agtctatttg ctttacggat ttgtcaccct cacgctcatc tgcagcctca 29940
tcactgtggt catcgccttt atccagtgca ttgactgggt ctgtgtgcgc tttgcatatc 30000
tcagacacca tccccagtac agggacagga ctatagctga gcttcttaga attctttaat 30060
tatgaaattt actgtgactt ttctgctgat tatttgcacc ctatctgcgt tttgttcccc 30120
gacctccaag cctcaaagac atatatcatg cagattcact cgtatatgga atattccaag 30180
ttgctacaat gaaaaaagcg atctttccga agcctggtta tatgcaatca tctctgttat 30240
ggtgttctgc agtaccatct tagccctagc tatatatccc taccttgaca ttggctggaa 30300
acgaatagat gccatgaacc acccaacttt ccccgcgccc gctatgcttc cactgcaaca 30360
agttgttgcc ggcggctttg tcccagccaa tcagcctcgc cccacttctc ccacccccac 30420
tgaaatcagc tactttaatc taacaggagg agatgactga caccctagat ctagaaatgg 30480
acggaattat tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc 30540
gcatgaatca agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt 30600
gtctggtaaa gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct 30660
acaagttgcc aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca 30720
taactcagca ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg 30780
atctctgcac ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat 30840
aaaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta 30900
ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca 30960
aactttctcc acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc 31020
actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc 31080
gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt 31140
gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa 31200
cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac 31260
gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc 31320
aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact 31380
gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc 31440
ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca 31500
gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt 31560
actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa 31620
gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta 31680
acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact 31740
tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt 31800
aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt 31860
tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata 31920
aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca 31980
aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct 32040
acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac 32100
acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg 32160
gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac 32220
aaaaataatg ataagctaac tttgtggacc acaccagctc catctcctaa ctgtagacta 32280
aatgcagaga aagatgctaa actcactttg gtcttaacaa aatgtggcag tcaaatactt 32340
gctacagttt cagttttggc tgttaaaggc agtttggctc caatatctgg aacagttcaa 32400
agtgctcatc ttattataag atttgacgaa aatggagtgc tactaaacaa ttccttcctg 32460
gacccagaat attggaactt tagaaatgga gatcttactg aaggcacagc ctatacaaac 32520
gctgttggat ttatgcctaa cctatcagct tatccaaaat ctcacggtaa aactgccaaa 32580
agtaacattg tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt aacactaacc 32640
attacactaa acggtacaca ggaaacagga gacacaactc caagtgcata ctctatgtca 32700
ttttcatggg actggtctgg ccacaactac attaatgaaa tatttgccac atcctcttac 32760
actttttcat acattgccca agaataaaga atcgtttgtg ttatgtttca acgtgtttat 32820
ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 32880
tagcttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 32940
acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat 33000
catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 33060
caaacgctca tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct 33120
gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg 33180
agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 33240
ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 33300
ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 33360
ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33420
aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33480
agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33540
cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33600
tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33660
ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 33720
ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33780
cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 33840
aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33900
cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33960
agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 34020
caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 34080
tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 34140
tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 34200
tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 34260
cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 34320
cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 34380
aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 34440
aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 34500
ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 34560
ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 34620
agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 34680
ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 34740
gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 34800
gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca 34860
tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 34920
ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 34980
caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 35040
aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 35100
gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 35160
tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 35220
gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 35280
agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 35340
gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35400
cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35460
ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35520
agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35580
acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35640
aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35700
aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35760
tttcccacgt tacgtaactt cccattttaa gaaaactaca attcccaaca catacaagtt 35820
actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35880
tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35938
<210> 138
<211> 34794
<212> DNA
<213> 人腺病毒B2（Human adenovirus B2）
<400> 138
catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60
aaaagtgtgg atcgtgtggt gattggctgt ggggttaacg gctaaaaggg gcggtgcgac 120
cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180
acgcataaaa aggctttttt ctcacggaac tacttagttt tcccacggta tttaacagga 240
aatgaggtag ttttgaccgg atgcaagtga aaattgttga ttttcgcgcg aaaactgaat 300
gaggaagtgt ttttctgaat aatgtggtat ttatggcagg gtggagtatt tgttcagggc 360
caggtagact ttgacccatt acgtggaggt ttcgattacc gtgtttttta cctgaatttc 420
cgcgtaccgt gtcaaagtct tctgttttta cgtaggtgtc agctgatcgc tagggtattt 480
atacctcagg gtttgtgtca agaggccact cttgagtgcc agcgagaaga gttttctcct 540
ctgcgccggc agtttaataa taaaaaaatg agagatttgc gatttctgcc tcaggaaata 600
atctctgctg agactggaaa tgaaatattg gagcttgtgg tgcacgccct gatgggagac 660
gatccggagc cacctgtgca gctttttgag cctcctacgc ttcaggaact gtatgattta 720
gaggtagagg gatcggagga ttctaatgag gaagctgtaa atggcttttt taccgattct 780
atgcttttag ctgctaatga agggttagaa ttagatccgc ctttggacac ttttgatact 840
ccaggggtaa ttgtggaaag cggtacaggt gtaagaaaat tacctgattt gagttccgtg 900
gactgtgatt tgcactgcta tgaagacggg tttcctccga gtgatgagga ggaccatgaa 960
aaggagcagt ccatgcagac tgcagcgggt gagggagtga aggctgccaa tgttggtttt 1020
cagttggatt gcccggagct tcctggacat ggctgtaagt cttgtgaatt tcacaggaaa 1080
aatactggag taaaggaact gttatgttcg ctttgttata tgagaacgca ctgccacttt 1140
atttacagta agtgtgttta agttaaaatt taaaggaata tgctgttttt cacatgtata 1200
ttgagtgtga gttttgtgct tcttattata ggtcctgtgt ctgatgctga tgaatcacca 1260
tctcctgatt ctactacctc acctcctgag attcaagcac ctgttcctgt ggacgtgcgc 1320
aagcccattc ctgtgaagct taagcctggg aaacgtccag cagtggaaaa acttgaggac 1380
ttgttacagg gtggggacgg acctttggac ttgagtacac ggaaacgtcc aagacaataa 1440
gtgttccata tccgtgttta cttaaggtga cgtcaatatt tgtgtgacag tgcaatgtaa 1500
taaaaatatg ttaactgttc actggttttt attgcttttt gggcggggac tcaggtatat 1560
aagtagaagc agacctgtgt ggttagctca taggagctgg ctttcatcca tggaggtttg 1620
ggccattttg gaagacctta ggaagactag gcaactgtta gagaacgctt cggacggagt 1680
ctccggtttt tggagattct ggttcgctag tgaattagct agggtagttt ttaggataaa 1740
acaggactat aaccaagaat ttgaaaagtt gttggtagat tgcccaggac tttttgaagc 1800
tcttaatttg ggccatcagg ttcactttaa agaaaaagtt ttatcagttt tagacttttc 1860
aaccccaggt agaactgctg ctgctgtggc ttttcttact tttatattag ataaatggat 1920
cccgcagact catttcagca ggggatacgt tttggatttc atagccacag cattgtggag 1980
aacatggaag gttcgcaaga tgaggacaat cttaggttac tggccagtgc agcctttggg 2040
tgtagcggga atcctgaggc atccaccggt catgccagcg gttctggagg aggaacagca 2100
agaggacaac ccgagagccg gcctggaccc tccagtggag gaggcggagt agctgacttg 2160
tctcctgaac tgcaacgggt gcttactgga tctacgtcca ctggacggga taggggcgtt 2220
aagagggaga gggcatctag tggtactgat gctagatctg agttggcttt aagtttaatg 2280
agtcgcagac gtcctgaaac catttggtgg catgaggttc agaaagaggg aagggatgaa 2340
gtttctgtat tgcaggagaa atattcactg gaacaggtga aaacatgttg gttggagcct 2400
gaggatgatt gggaggtggc cattaaaaat tatgccaaga tagctttgag gcctgataaa 2460
cagtataaga ttactagacg gattaatatc cggaatgctt gttacatatc tggaaatggg 2520
gctgaggtgg taatagatac tcaagacaag gcagttatta gatgctgcat gatggatatg 2580
tggcctgggg tagtcggtat ggaagcagta acttttgtaa atgttaagtt taggggagat 2640
ggttataatg gaatagtgtt tatggccaat accaaactta tattgcatgg ttgtagcttt 2700
tttggtttca acaatacctg tgtagatgcc tggggacagg ttagtgtacg gggatgtagt 2760
ttctatgcgt gttggattgc cacagctggc agaaccaaga gtcaattgtc tctgaagaaa 2820
tgcatatttc aaagatgtaa cctgggcatt ctgaatgaag gcgaagcaag ggtccgccac 2880
tgcgcttcta cagatactgg atgttttatt ttgattaagg gaaatgccag cgtaaagcat 2940
aacatgattt gcggtgcttc cgatgagagg ccttatcaaa tgctcacttg tgctggtggg 3000
cattgtaata tgctggctac tgtgcatatt gtttcccatc aacgcaaaaa atggcctgtt 3060
tttgatcaca atgtgatgac gaagtgtacc atgcatgcag gtgggcgtag aggaatgttt 3120
atgccttacc agtgtaacat gaatcatgtg aaagtgttgt tggaaccaga tgccttttcc 3180
agaatgagcc taacaggaat ttttgacatg aacatgcaaa tctggaagat cctgaggtat 3240
gatgatacga gatcgagggt acgcgcatgc gaatgcggag gcaagcatgc caggttccag 3300
ccggtgtgtg tagatgtgac tgaagatctc agaccggatc atttggttat tgcccgcact 3360
ggagcagagt tcggatccag tggagaagaa actgactaag gtgagtattg ggaaaacttt 3420
ggggtgggat tttcagatgg acagattgag taaaaatttg ttttttctgt cttgcagctg 3480
tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540
tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600
tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660
cagctgcagc tgccgccgcc gcttctgttg ccgctaacac tgtgcttgga atgggttact 3720
atggaagcat catggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780
agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttctc 3840
agcaggtggt cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900
aaaaaaatcc cagaatcaat gaataaataa acaagcttgt tgttgattta aaatcaagtg 3960
tttttatttc atttttcgcg cacggtatgc cctagaccac cgatctctat cattgagaac 4020
tcggtggatt ttttccagga tcctatagag gtgggattga atgtttagat acatgggcat 4080
taggccgtct ttggggtgga gatagctcca ttgaagggat tcatgctccg gggtagtgtt 4140
gtaaatcacc cagtcataac aaggtcgcag tgcatggtgt tgcacaatat cttttagaag 4200
taggctgatt gccacagata agcccttggt gtaggtgttt acaaaccggt tgagctggga 4260
tgggtgcatt cggggtgaaa ttatgtgcat tttggattgg atttttaagt tggcaatatt 4320
gccgccaaga tcccgtcttg ggttcatgtt atgaaggacc accaagacgg tgtatccggt 4380
acatttagga aatttatcgt gcagcttgga tggaaaagcg tggaaaaatt tggagacacc 4440
cttgtgtcct ccaagatttt ccatgcactc atccatgata atagcaatgg ggccgtgggc 4500
agcggcgcgg gcaaacacgt tccgtgggtc tgacacatca tagttatgtt cctgagttaa 4560
atcatcataa gccattttaa tgaatttggg gcggagagta ccagattggg gtatgaatgt 4620
tccttcgggc cccggagcat agttcccctc acagatttgc atttcccaag ctttcagttc 4680
cgagggtgga atcatgtcca cctggggggc tatgaaaaac accgtttctg gggcgggggt 4740
gattaattgt gatgatagca aatttctgag caattgagat ttgccacatc cggtggggcc 4800
ataaatgatt ccgattacgg gttgcaggtg gtagtttagg gaacggcaac tgccgtcttc 4860
tcgaagcaag ggggccacct cgttcatcat ttcccttaca tgcatatttt cccgcaccaa 4920
atccattagg aggcgctctc ctcctagtga tagaagttct tgtagtgagg aaaagttttt 4980
cagcggtttc agaccgtcag ccatgggcat tttggagaga gtttgctgca aaagttctag 5040
tctgttccac agttcagtga tgtgttctat ggcatctcga tccagcagac ctcctcgttt 5100
cgcgggtttg gacggctcct ggaatagggt atgagacgat gggcgtccag cgctgccagg 5160
gttcggtcct tccagggtct cagtgttcga gtcagggttg tttccgtcac agtgaagggg 5220
tgtgcgcctg cttgggcgct tgccagggtg cgcttcagac tcatcctgct ggtcgaaaac 5280
ttctgtcgct tggcgccctg tatgtcggcc aagtagcagt ttaccatgag ttcgtagttg 5340
agcgcctcgg ctgcgtggcc tttggcgcgg agcttacctt tggaagtttt cttgcatacc 5400
gggcagtata ggcatttcag cgcatacaac ttgggcgcaa ggaaaacgga ttctggggag 5460
tatgcatctg cgccgcagga ggcgcaaaca gtttcacatt ccaccagcca ggttaaatcc 5520
ggttcattgg ggtcaaaaac aagttttccg ccatattttt tgatgcgttt cttacctttg 5580
gtctccatga gttcgtgtcc tcgttgagtg acaaacaggc tgtccgtgtc cccgtagact 5640
gattttacag gcctcttctc cagtggagtg cctcggtctt cttcgtacag gaactctgac 5700
cactctgata caaaggcgcg cgtccaggcc agcacaaagg aggctatgtg ggaggggtag 5760
cgatcgttgt caaccagggg gtccaccttt tccaaagtat gcaaacacat gtcaccctct 5820
tcaacatcca ggaatgtgat tggcttgtag gtgtatttca cgtgacctgg ggtccccgct 5880
gggggggtat aaaagggggc ggttctttgc tcttcctcac tgtcttccgg atcgctgtcc 5940
aggaacgtca gctgttgggg taggtattcc ctctcgaagg cgggcatgac ctctgcactc 6000
aggttgtcag tttctaagaa cgaggaggat ttgatattga cagtgccggt tgagatgcct 6060
ttcatgaggt tttcgtccat ttggtcagaa aacacaattt ttttattgtc aagtttggtg 6120
gcaaatgatc catacagggc gttggataaa agtttggcaa tggatcgcat ggtttggttc 6180
ttttccttgt ccgcgcgctc tttggcggcg atgttgagtt ggacatactc gcgtgccagg 6240
cacttccatt cggggaagat agttgttaat tcatctggca cgattctcac ttgccaccct 6300
cgattatgca aggtaattaa atccacactg gtggccacct cgcctcgaag gggttcattg 6360
gtccaacaga gcctacctcc tttcctagaa cagaaagggg gaagtgggtc tagcataagt 6420
tcatcgggag ggtctgcatc catggtaaag attcccggaa gtaaatcctt atcaaaatag 6480
ctgatgggag tggggtcatc taaggccatt tgccattctc gagctgccag tgcgcgctca 6540
tatgggttaa ggggactgcc ccatggcatg ggatgggtga gtgcagaggc atacatgcca 6600
cagatgtcat agacgtagat gggatcctca aagatgccta tgtaggttgg atagcatcgc 6660
ccccctctga tacttgctcg cacatagtca tatagttcat gtgatggcgc tagcagcccc 6720
ggacccaagt tggtgcgatt gggtttttct gttctgtaga cgatctggcg aaagatggcg 6780
tgagaattgg aagagatggt gggtctttga aaaatgttga aatgggcatg aggtagacct 6840
acagagtctc tgacaaagtg ggcataagat tcttgaagct tggttaccag ttcggcggtg 6900
acaagtacgt ctagggcgca gtagtcaagt gtttcttgaa tgatgtcata acctggttgg 6960
tttttctttt cccacagttc gcggttgaga aggtattctt cgcgatcctt ccagtactct 7020
tctagcggaa acccgtcttt gtctgcacgg taagatccta gcatgtagaa ctgattaact 7080
gccttgtaag ggcagcagcc cttctctacg ggtagagagt atgcttgagc agcttttcgt 7140
agcgaagcgt gagtaagggc aaaggtgtct ctgaccatga ctttgagaaa ttggtatttg 7200
aagtcgatgt cgtcacaggc tccctgttcc cagagttgga agtctacccg tttcttgtag 7260
gcggggttgg gcaaagcgaa agtaacatca ttgaagagaa tcttaccggc tctgggcata 7320
aaattgcgag tgatgcgaaa aggctgtggt acttccgctc gattgttgat cacctgggca 7380
gctaggacga tctcgtcgaa accgttgatg ttgtgtccta cgatgtataa ttctatgaaa 7440
cgcggcgtgc ctctgacgtg aggtagctta ctgagctcat caaaggttag gtctgtgggg 7500
tcagataagg cgtagtgttc gagagcccat tcgtgcaggt gaggatttgc atgtaggaat 7560
gatgaccaaa gatctaccgc cagtgctgtt tgtaactggt cccgatactg acgaaaatgc 7620
cggccaattg ccattttttc tggagtgaca cagtagaagg ttctggggtc ttgttgccat 7680
cgatcccact tgagtttaat ggctagatcg tgggccatgt tgacgagacg ctcttctcct 7740
gagagtttca tgaccagcat gaaaggaact agttgtttgc caaaggatcc catccaggtg 7800
taagtttcca catcgtaggt caggaagagt ctttctgtgc gaggatgaga gccgatcggg 7860
aagaactgga tttcctgcca ccagttggag gattggctgt tgatgtgatg gaagtagaag 7920
tttctgcggc gcgccgagca ttcgtgtttg tgcttgtaca gacggccgca gtagtcgcag 7980
cgttgcacgg gttgtatctc gtgaatgagt tgtacctggc ttcccttgac gagaaatttc 8040
agtgggaagc cgaggcctgg cgattgtatc tcgtgctctt ctatattcgc tgtatcggcc 8100
tgttcatctt ctgtttcgat ggtggtcatg ctgacgagcc cccgcgggag gcaagtccag 8160
acctcggcgc gggaggggcg gagctgaagg acgagagcgc gcaggctgga gctgtccaga 8220
gtcctgagac gctgcggact caggttagta ggtagggaca gaagattaac ttgcatgatc 8280
ttttccaggg cgtgcgggag gttcagatgg tacttgattt ccacaggttc gtttgtagag 8340
acgtcaatgg cttgcagggt tccgtgtcct ttgggcgcca ctaccgtacc tttgtttttt 8400
cttttgatcg gtggtggctc tcttgcttct tgcatgctca gaagcggtga cggggacgcg 8460
cgccgggcgg cagcggttgt tccggacccg agggcatggc tggtagtggc acgtcggcgc 8520
cgcgcacggg caggttctgg tactgcgctc tgagaagact tgcgtgcgcc accacgcgtc 8580
gattgacgtc ttgtatctga cgtctctggg tgaaagctac cggccccgtg agcttgaacc 8640
tgaaagagag ttcaacagaa tcaatttcgg tatcgttaac ggcagcttgt ctcagtattt 8700
cttgtacgtc accagagttg tcctggtagg cgatctccgc catgaactgc tcgatttctt 8760
cctcctgaag atctccgcga cccgctcttt cgacggtggc cgcgaggtca ttggagatac 8820
ggcccatgag ttgggagaat gcattcatgc ccgcctcgtt ccagacgcgg ctgtaaacca 8880
cggccccctc ggagtctctt gcgcgcatca ccacctgagc gaggttaagc tccacgtgtc 8940
tggtgaagac cgcatagttg cataggcgct gaaaaaggta gttgagtgtg gtggcaatgt 9000
gttcggcgac gaagaaatac atgatccatc gtctcagcgg catttcgcta acatcgccca 9060
gagcttccaa gcgctccatg gcctcgtaga agtccacggc aaaattaaaa aactgggagt 9120
ttcgcgcgga cacggtcaat tcctcctcga gaagacggat gagttcggct atggtggccc 9180
gtacttcgcg ttcgaaggct cccgggatct cttcttcctc ttctatctct tcttccacta 9240
acatctcttc ttcgtcttca ggcgggggcg gagggggcac gcggcgacgt cgacggcgca 9300
cgggcaaacg gtcgatgaat cgttcaatga cctctccgcg gcggcggcgc atggtttcag 9360
tgacggcgcg gccgttctcg cgcggtcgca gagtaaaaac accgccgcgc atctccttaa 9420
agtggtgact gggaggttct ccgtttggga gggagagggc gctgattata cattttatta 9480
attggcccgt agggactgca cgcagagatc tgatcgtgtc aagatccacg ggatctgaaa 9540
acctttcgac gaaagcgtct aaccagtcac agtcacaagg taggctgagt acggcttctt 9600
gtgggcgggg gtggttatgt gttcggtctg ggtcttctgt ttcttcttca tctcgggaag 9660
gtgagacgat gctgctggtg atgaaattaa agtaggcagt tctaagacgg cggatggtgg 9720
cgaggagcac caggtctttg ggtccggctt gctggatacg caggcgattg gccattcccc 9780
aagcattatc ctgacatcta gcaagatctt tgtagtagtc ttgcatgagc cgttctacgg 9840
gcacttcttc ctcacccgtt ctgccatgca tacgtgtgag tccaaatccg cgcattggtt 9900
gtaccagtgc caagtcagct acgactcttt cggcgaggat ggcttgctgt acttgggtaa 9960
gggtggcttg aaagtcatca aaatccacaa agcggtggta agctcctgta ttaatggtgt 10020
aagcacagtt ggccatgact gaccagttaa ctgtctggtg accagggcgc acgagctcgg 10080
tgtatttaag gcgcgaatag gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca 10140
gatactggta ccctataaga aaatgcggcg gtggttggcg gtagagaggc catcgttctg 10200
tagctggagc gccaggggcg aggtcttcca acataaggcg gtgatagccg tagatgtacc 10260
tggacatcca ggtgattcct gcggcggtag tagaagcccg aggaaactcg cgtacgcggt 10320
tccaaatgtt gcgtagcggc atgaagtagt tcattgtagg cacggtttga ccagtgaggc 10380
gcgcgcagtc attgatgctc tatagacacg gagaaaatga aagcgttcag cgactcgact 10440
ccgtagcctg gaggaacgtg aacgggttgg gtcgcggtgt accccggttc gagacttgta 10500
ctcgagccgg ccggagccgc ggctaacgtg gtattggcac tcccgtctcg acccagccta 10560
caaaaatcca ggatacggaa tcgagtcgtt ttgctggttt ccgaatggca gggaagtgag 10620
tcctattttt tttttttgcc gctcagatgc atcccgtgct gcgacagatg cgcccccaac 10680
aacagccccc ctcgcagcag cagcagcagc aatcacaaaa ggctgtccct gcaactactg 10740
caactgccgc cgtgagcggt gcgggacagc ccgcctatga tctggacttg gaagagggcg 10800
aaggactggc acgtctaggt gcgccttcac ccgagcggca tccgcgagtt caactgaaaa 10860
aagattctcg cgaggcgtat gtgccccaac agaacctatt tagagacaga agcggcgagg 10920
agccggagga gatgcgagct tcccgcttta acgcgggtcg tgagctgcgt cacggtttgg 10980
accgaagacg agtgttgcgg gacgaggatt tcgaagttga tgaaatgaca gggatcagtc 11040
ctgccagggc acacgtggct gcagccaacc ttgtatcggc ttacgagcag acagtaaagg 11100
aagagcgtaa cttccaaaag tcttttaata atcatgtgcg aaccctgatt gcccgcgaag 11160
aagttaccct tggtttgatg catttgtggg atttgatgga agctatcatt cagaacccta 11220
ctagcaaacc tctgaccgcc cagctgtttc tggtggtgca acacagcaga gacaatgagg 11280
ctttcagaga ggcgctgctg aacatcaccg aacccgaggg gagatggttg tatgatctta 11340
tcaacattct acagagtatc atagtgcagg agcggagcct gggcctggcc gagaaggtgg 11400
ctgccatcaa ttactcggtt ttgagcttgg gaaaatatta cgctcgcaaa atctacaaga 11460
ctccatacgt tcccatagac aaggaggtga agatagatgg gttctacatg cgcatgacgc 11520
tcaaggtctt gaccctgagc gatgatcttg gggtgtatcg caatgacaga atgcatcgcg 11580
cggttagcgc cagcaggagg cgcgagttaa gcgacaggga actgatgcac agtttgcaaa 11640
gagctctgac tggagctgga accgagggtg agaattactt cgacatggga gctgacttgc 11700
agtggcagcc tagtcgcagg gctctgagcg ccgcgacggc aggatgtgag cttccttaca 11760
tagaagaggc ggatgaaggc gaggaggaag agggcgagta cttggaagac tgatggcaca 11820
acccgtgttt tttgctagat ggaacagcaa gcaccggatc ccgcaatgcg ggcggcgctg 11880
cagagccagc cgtccggcat taactcctcg gacgattgga cccaggccat gcaacgtatc 11940
atggcgttga cgactcgcaa ccccgaagcc tttagacagc aaccccaggc caaccgtcta 12000
tcggccatca tggaagctgt agtgccttcc cgctctaatc ccactcatga gaaggtcctg 12060
gccatcgtga acgcgttggt ggagaacaaa gctattcgtc cagatgaggc cggactggta 12120
tacaacgctc tcttagaacg cgtggctcgc tacaacagta gcaatgtgca aaccaatttg 12180
gaccgtatga taacagatgt acgcgaagcc gtgtctcagc gcgaaaggtt ccagcgtgat 12240
gccaacctgg gttcgctggt ggcgttaaat gctttcttga gtactcagcc tgctaatgtg 12300
ccgcgtggtc aacaggatta tactaacttt ttaagcgctt tgagactgat ggtatcagaa 12360
gtacctcaga gcgaagtgta tcagtccggt cctgattact tctttcagac tagcagacag 12420
ggcttgcaga cggtaaatct gagccaagct tttaaaaacc ttaaaggttt gtggggagtg 12480
catgccccgg taggagaaag agcaaccgtg tctagcttgt taactccgaa ctcccgccta 12540
ttattactgt tggtagctcc tttcaccgac agcggtagca tcgaccgtaa ttcctatttg 12600
ggttacctac taaacctgta tcgcgaagcc atagggcaaa gtcaggtgga cgagcagacc 12660
tatcaagaaa ttacccaagt cagtcgcgct ttgggacagg aagacactgg cagtttggaa 12720
gccactctga acttcttgct taccaatcgg tctcaaaaga tccctcctca atatgctctt 12780
actgcggagg aggagaggat ccttagatat gtgcagcaga gcgtgggatt gtttctgatg 12840
caagaggggg caactccgac tgcagcactg gacatgacag cgcgaaatat ggagcccagc 12900
atgtatgcca gtaaccgacc tttcattaac aaactgctgg actacttgca cagagctgcc 12960
gctatgaact ctgattattt caccaatgcc atcttaaacc cgcactggct gcccccacct 13020
ggtttctaca cgggcgaata tgacatgccc gaccctaatg acggatttct gtgggacgac 13080
gtggacagcg atgttttttc acctctttct gatcatcgca cgtggaaaaa ggaaggcggc 13140
gatagaatgc attcttctgc atcgctgtcc ggggtcatgg gtgctaccgc ggctgagccc 13200
gagtctgcaa gtccttttcc tagtctaccc ttttctctac acagtgtacg tagcagcgaa 13260
gtgggtagaa taagtcgccc gagtttaatg ggcgaagagg agtatctaaa cgattccttg 13320
ctcagaccgg caagagaaaa aaatttccca aacaatggaa tagaaagttt ggtggataaa 13380
atgagtagat ggaagactta tgctcaggat cacagagacg agcctgggat catggggatt 13440
acaagtagag cgagccgtag acgccagcgc catgacagac agaggggtct tgtgtgggac 13500
gatgaggatt cggccgatga tagcagcgtg ctggacttgg gtgggagagg aaggggcaac 13560
ccgtttgctc atttgcgccc tcgcttgggt ggtatgttgt aaaaaaaaat aaaaaaaaaa 13620
ctcaccaagg ccatggcgac gagcgtacgt tcgttcttct ttattatctg tgtctagtat 13680
aatgaggcga gtcgtgctag gcggagcggt ggtgtatccg gagggtcctc ctccttcgta 13740
cgagagcgtg atgcagcagc agcaggcgac ggcggtgatg caatccccac tggaggctcc 13800
ctttgtgcct ccgcgatacc tggcacctac ggagggcaga aacagcattc gttattcgga 13860
actggcacct cagtacgata ccaccaggtt gtatctggtg gacaacaagt cggcggacat 13920
tgcttctctg aactatcaga atgaccacag caacttcttg accacggtgg tgcaaaacaa 13980
tgactttacc cctacggaag ccagcaccca gaccattaac tttgatgaac gatcgcggtg 14040
gggcggtcag ctaaagacca tcatgcatac taacatgcca aacgtgaacg agtatatgtt 14100
tagtaacaag ttcaaagcgc gtgtgatggt gtccagaaaa cctcccgacg gtgctgcagt 14160
tggggatact tatgatcaca agcaggatat tttgaaatat gagtggttcg agtttacttt 14220
gccagaaggc aacttttcag ttactatgac tattgatttg atgaacaatg ccatcataga 14280
taattacttg aaagtgggta gacagaatgg agtgcttgaa agtgacattg gtgttaagtt 14340
cgacaccagg aacttcaagc tgggatggga tcccgaaacc aagttgatca tgcctggagt 14400
gtatacgtat gaagccttcc atcctgacat tgtcttactg cctggctgcg gagtggattt 14460
taccgagagt cgtttgagca accttcttgg tatcagaaaa aaacagccat ttcaagaggg 14520
ttttaagatt ttgtatgaag atttagaagg tggtaatatt ccggccctct tggatgtaga 14580
tgcctatgag aacagtaaga aagaacaaaa agccaaaata gaagctgcta cagctgctgc 14640
agaagctaag gcaaacatag ttgccagcga ctctacaagg gttgctaacg ctggagaggt 14700
cagaggagac aattttgcgc caacacctgt tccgactgca gaatcattat tggccgatgt 14760
gtctgaagga acggacgtga aactcactat tcaacctgta gaaaaagata gtaagaatag 14820
aagctataat gtgttggaag acaaaatcaa cacagcctat cgcagttggt atctttcgta 14880
caattatggc gatcccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt 14940
cacctgcgga gcagagcagg tctactggtc gcttccagac atgatgaagg atcctgtcac 15000
tttccgctcc actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt 15060
cttctcaaag agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac 15120
ctcgcttacg cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc 15180
gcccaccatt accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc 15240
gttgcgcagc agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac 15300
ctgtccctac gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac 15360
tttctaaaaa aaaaaaaaat gtccattctt atctcgccca gtaataacac cggttggggt 15420
ctgcgcgctc caagcaagat gtacggaggc gcacgcaaac gttctaccca acatcctgtc 15480
cgtgttcgcg gacattttcg cgctccatgg ggcgccctca agggccgcac tcgcgttcga 15540
accaccgtcg atgatgtaat cgatcaggtg gttgccgacg cccgtaatta tactcctact 15600
gcgcctacat ctactgtgga tgcagttatt gacagtgtag tggctgacgc tcgcaactat 15660
gctcgacgta agagccggcg aaggcgcatt gccagacgcc accgagctac cactgccatg 15720
cgagccgcaa gagctctgct acgaagagct agacgcgtgg ggcgaagagc catgcttagg 15780
gcggccagac gtgcagcttc gggcgccagc gccggcaggt cccgcaggca agcagccgct 15840
gtcgcagcgg cgactattgc cgacatggcc caatcgcgaa gaggcaatgt atactgggtg 15900
cgtgacgctg ccaccggtca acgtgtaccc gtgcgcaccc gtccccctcg cacttagaag 15960
atactgagca gtctccgatg ttgtgtccca gcggcgagga tgtccaagcg caaatacaag 16020
gaagaaatgc tgcaggttat cgcacctgaa gtctacggcc aaccgttgaa ggatgaaaaa 16080
aaaccccgca aaatcaagcg ggttaaaaag gacaaaaaag aagaggaaga tggcgatgat 16140
gggctggcgg agtttgtgcg cgagtttgcc ccacggcgac gcgtgcaatg gcgtgggcgc 16200
aaagttcgac atgtgttgag acctggaact tcggtggtct ttacacccgg cgagcgttca 16260
agcgctactt ttaagcgttc ctatgatgag gtgtacgggg atgatgatat tcttgagcag 16320
gcggctgacc gattaggcga gtttgcttat ggcaagcgta gtagaataac ttccaaggat 16380
gagacagtgt cgataccctt ggatcatgga aatcccaccc ctagtcttaa accggtcact 16440
ttgcagcaag tgttacccgt aactccgcga acaggtgtta aacgcgaagg tgaagatttg 16500
tatcccacta tgcaactgat ggtacccaaa cgccagaagt tggaggacgt tttggagaaa 16560
gtaaaagtgg atccagatat tcaacctgag gttaaagtga gacccattaa gcaggtagcg 16620
cctggtctgg gggtacaaac tgtagacatt aagattccca ctgaaagtat ggaagtgcaa 16680
actgaacccg caaagcctac tgccacctcc actgaagtgc aaacggatcc atggatgccc 16740
atgcctatta caactgacgc cgccggtccc actcgaagat cccgacgaaa gtacggtcca 16800
gcaagtctgt tgatgcccaa ttatgttgta cacccatcta ttattcctac tcctggttac 16860
cgaggcactc gctactatcg cagccgaaac agtacctccc gccgtcgccg caagacacct 16920
gcaaatcgca gtcgtcgccg tagacgcaca agcaaaccga ctcccggcgc cctggtgcgg 16980
caagtgtacc gcaatggtag tgcggaacct ttgacactgc cgcgtgcgcg ttaccatccg 17040
agtatcatca cttaatcaat gttgccgctg cctccttgca gatatggccc tcacttgtcg 17100
ccttcgcgtt cccatcactg gttaccgagg aagaaactcg cgccgtagaa gagggatgtt 17160
gggacgcgga atgcgacgct acaggcgacg gcgtgctatc cgcaagcaat tgcggggtgg 17220
ttttttacca gccttaattc caattatcgc tgctgcaatt ggcgcgatac caggcatagc 17280
ttccgtggcg gttcaggcct cgcaacgaca ttgacattgg aaaaaaacgt ataaataaaa 17340
aaaaaaaaat acaatggact ctgacactcc tggtcctgtg actatgtttt cttagagatg 17400
gaagacatca atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc 17460
tggagcgaca tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg 17520
agcgggctta aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc 17580
agtacaggac aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc 17640
gatgggatag cttccggcat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa 17700
aagataaaca gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa 17760
gaaattcctc cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg 17820
ctggtgacgc gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc 17880
accactagac cgatagcccc aatggccacc ggggtgatga aaccttctca gttgcatcga 17940
cccgtcacct tggatttgcc ccctccccct gctgctactg ctgtacccgc ttctaagcct 18000
gtcgctgccc cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca 18060
aatgcgcact ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa 18120
cgccgtcgct gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg 18180
tgtcattaca cgccgtcaca gcagcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg 18240
agttactttc aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc 18300
cggacaggat gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga 18360
cacctacttc aatctgggaa ataagtttag aaatcccacc gtagcgccga cccacgatgt 18420
gaccaccgac cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa 18480
tacatactct tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat 18540
ggccagcacg ttctttgaca ttaggggtgt gttggacaga ggtcccagtt tcaaacccta 18600
ttctggtacg gcttacaact ccctggctcc taaaggcgct ccaaatacat ctcagtggat 18660
tgcagaaggt gtaaaaaata caactggtga ggaacacgta acagaagagg aaaccaatac 18720
tactacttac acttttggca atgctcctgt aaaagctgaa gctgaaatta caaaagaagg 18780
actcccagta ggtttggaag tttcagatga agaaagtaaa ccgatttatg ctgataaaac 18840
atatcagcca gaacctcagc tgggagatga aacttggact gaccttgatg gaaaaaccga 18900
aaagtatgga ggcagggctc tcaaacccga tactaagatg aaaccatgct acgggtcctt 18960
tgccaaacct actaatgtga aaggcggtca ggcaaaacaa aaaacaacgg agcagccaaa 19020
tcagaaagtc gaatatgata tcgacatgga gttttttgat gcggcatcgc agaaaacaaa 19080
cttaagtcct aaaattgtca tgtatgcaga aaatgtaaat ttggaaactc cagacactca 19140
tgtagtgtac aaacctggaa cagaagacac aagttccgaa gctaatttgg gacaacaatc 19200
tatgcccaac agacccaact acattggctt cagagataac tttattggac ttatgtacta 19260
taacagtact ggtaacatgg gggtgctggc tggtcaagcg tctcagttaa atgcagtggt 19320
tgacttgcag gacagaaaca cagaactttc ttaccaactc ttgcttgact ctctgggcga 19380
cagaaccaga tactttagca tgtggaatca ggctgtggac agttatgatc ctgatgtacg 19440
tgttattgaa aatcatggtg tggaagatga acttcccaac tactgttttc cactggacgg 19500
cataggtgtt ccaacaacca gttacaaatc aatagttcca aatggagaca atgcgcctaa 19560
ttggaaggaa cctgaagtaa atggaacaag tgagatcgga cagggtaatt tgtttgccat 19620
ggaaattaac cttcaagcca atctatggcg aagtttcctt tattccaatg tggctctata 19680
tctcccagac tcgtacaaat acaccccgtc caatgtcact cttccagaaa acaaaaacac 19740
ctacgactac atgaacgggc gggtggtgcc gccatctcta gtagacacct atgtgaacat 19800
tggtgccagg tggtctctgg atgccatgga caatgtcaac ccattcaacc accaccgtaa 19860
cgctggcttg cgttaccgat ccatgcttct gggtaacgga cgttatgtgc ctttccacat 19920
acaagtgcct caaaaattct tcgctgttaa aaacctgctg cttctcccag gctcctacac 19980
ttatgagtgg aactttagga aggatgtgaa catggttcta cagagttccc tcggtaacga 20040
cctgcgggta gatggcgcca gcatcagttt cacgagcatc aacctctatg ctactttttt 20100
ccccatggct cacaacaccg cttccaccct tgaagccatg ctgcggaatg acaccaatga 20160
tcagtcattc aacgactacc tatctgcagc taacatgctc taccccattc ctgccaatgc 20220
aaccaatatt cccatttcca ttccttctcg caactgggcg gctttcagag gctggtcatt 20280
taccagactg aaaaccaaag aaactccctc tttggggtct ggatttgacc cctactttgt 20340
ctattctggt tctattccct acctggatgg taccttctac ctgaaccaca cttttaagaa 20400
ggtttccatc atgtttgact cttcagtgag ctggcctgga aatgacaggt tactatctcc 20460
taacgaattt gaaataaagc gcactgtgga tggcgaaggc tacaacgtag cccaatgcaa 20520
catgaccaaa gactggttct tggtacagat gctcgccaac tacaacatcg gctatcaggg 20580
cttctacatt ccagaaggat acaaagatcg catgtattca tttttcagaa acttccagcc 20640
catgagcagg caggtggttg atgaggtcaa ttacaaagac ttcaaggccg tcgccatacc 20700
ctaccaacac aacaactctg gctttgtggg ttacatggct ccgaccatgc gccaaggtca 20760
accctatccc gctaactatc cctatccact cattggaaca actgccgtaa atagtgttac 20820
gcagaaaaag ttcttgtgtg acagaaccat gtggcgcata ccgttctcga gcaacttcat 20880
gtctatgggg gcccttacag acttgggaca gaatatgctc tatgccaact cagctcatgc 20940
tctggacatg acctttgagg tggatcccat ggatgagccc accctgcttt atcttctctt 21000
cgaagttttc gacgtggtca gagtgcatca gccacaccgc ggcatcatcg aggcagtcta 21060
cctgcgtaca ccgttctcgg ccggtaacgc taccacgtaa gaagcttctt gcttcttgca 21120
aatagcagct gcaaccatgg cctgcggatc ccaaaacggc tccagcgagc aagagctcag 21180
agccattgtc caagacctgg gttgcggacc ctattttttg ggaacctacg ataagcgctt 21240
cccggggttc atggcccccg ataagctcgc ctgtgccatt gtaaatacgg ccggacgtga 21300
gacgggggga gagcactggt tggctttcgg ttggaaccca cgttctaaca cctgctacct 21360
ttttgatcct tttggattct cggatgatcg tctcaaacag atttaccagt ttgaatatga 21420
gggtctcctg cgccgcagcg ctcttgctac caaggaccgc tgtattacgc tggaaaaatc 21480
tacccagacc gtgcagggtc cccgttctgc cgcctgcgga cttttctgct gcatgttcct 21540
tcacgccttt gtgcactggc ctgaccgtcc catggacgga aaccccacca tgaaattgct 21600
aactggagtg ccaaacaaca tgcttcattc tcctaaagtc cagcccaccc tgtgtgacaa 21660
tcaaaaagca ctctaccatt ttcttaatac ccattcgcct tattttcgct cccatcgtac 21720
acacatcgaa agggccactg cgttcgaccg tatggatgtt caataatgac tcatgtaaac 21780
aacgtgttca ataaacatca ctttattttt ttacatgtat caaggctctg cattacttat 21840
ttatttacaa gtcgaatggg ttctgacgag aatcagaatg acccgcaggc agtgatacgt 21900
tgcggaactg atacttgggt tgccacttga attcgggaat caccaacttg ggaaccggta 21960
tatcgggcag gatgtcactc cacagctttc tggtcagctg caaagctcca agcaggtcag 22020
gagccgaaat cttgaaatca caattaggac cagtgctttg agcgcgagag ttgcggtaca 22080
ccggattgca gcactgaaac accatcagcg acggatgtct cacgcttgcc agcacggtgg 22140
gatctgcaat catgcccaca tccagatctt cagcattggc aatgctgaac ggggtcatct 22200
tgcaggtctg cctacccatg gcgggcaccc aattaggctt gtggttgcaa tcgcagtgca 22260
gggggatcag tatcatcttg gcctgatcct gtctgattcc tggatacacg gctctcatga 22320
aagcatcata ttgcttgaaa gcctgctggg ctttactacc ctcggtataa aacatcccgc 22380
aggacctgct cgaaaactgg ttagctgcac agccggcatc attcacacag cagcgggcgt 22440
cattgttagc tatttgcacc acacttctgc cccagcggtt ttgggtgatt ttggttcgct 22500
cgggattctc ctttaaggct cgttgtccgt tctcgctggc cacatccatc tcgataatct 22560
gctccttctg aatcataata ttgccatgca ggcacttcag cttgccctca taatcattgc 22620
agccatgagg ccacaacgca cagcctgtac attcccaatt atggtgggcg atctgagaaa 22680
aagaatgtat cattccctgc agaaatcttc ccatcatcgt gctcagtgtc ttgtgactag 22740
tgaaagttaa ctggatgcct cggtgctcct cgtttacgta ctggtgacag atgcgcttgt 22800
attgttcgtg ttgctcaggc attagtttaa aagaggttct aagttcgtta tccagcctgt 22860
acttctccat cagcagacac atcacttcca tgcctttctc ccaagcagac accaggggca 22920
agctaatcgg attcttaaca gtgcaggcag cagctccttt agccagaggg tcatctttag 22980
cgatcttctc aatgcttctt ttgccatcct tctcaacgat gcgcacgggc gggtagctga 23040
aacccactgc tacaagttgc gcctcttctc tttcttcttc gctgtcttga ctgatgtctt 23100
gcatggggat atgtttggtc ttccttggct tctttttggg gggtatcgga ggaggaggac 23160
tgtcgctccg ttccggagac agggaggatt gtgacgtttc gctcaccatt accaactgac 23220
tgtcggtaga agaacctgac cccacacggc gacaggtgtt tctcttcggg ggcagaggtg 23280
gaggcgattg cgaagggctg cggtccgacc tggaaggcgg atgactggca gaaccccttc 23340
cgcgttcggg ggtgtgctcc ctgtggcggt cgcttaactg atttccttcg cggctggcca 23400
ttgtgttctc ctaggcagag aaacaacaga catggaaact cagccattgc tgtcaacatc 23460
gccacgagtg ccatcacatc tcgtcctcag cgacgaggaa aaggagcaga gcttaagcat 23520
tccaccgccc agtcctgcca ccacctctac cctagaagat aaggaggtcg acgcatctca 23580
tgacatgcag aataaaaaag cgaaagagtc tgagacagac atcgagcaag acccgggcta 23640
tgtgacaccg gtggaacacg aggaagagtt gaaacgcttt ctagagagag aggatgaaaa 23700
ctgcccaaaa caacgagcag ataactatca ccaagatgct ggaaataggg atcagaacac 23760
cgactacctc atagggcttg acggggaaga cgcgctcctt aaacatctag caagacagtc 23820
gctcatagtc aaggatgcat tattggacag aactgaagtg cccatcagtg tggaagagct 23880
cagccgcgcc tacgagctta acctcttttc acctcgtact ccccccaaac gtcagccaaa 23940
cggcacctgc gagccaaatc ctcgcttaaa cttttatcca gcttttgctg tgccagaagt 24000
actggctacc tatcacatct tttttaaaaa tcaaaaaatt ccagtctcct gccgcgctaa 24060
tcgcacccgc gccgatgccc tactcaatct gggacctggt tcacgcttac ctgatatagc 24120
ttccttggaa gaggttccaa agatcttcga gggtctgggc aataatgaga ctcgggccgc 24180
aaatgctctg caaaagggag aaaatggcat ggatgagcat cacagcgttc tggtggaatt 24240
ggaaggcgat aatgccagac tcgcagtact caagcgaagc atcgaggtca cacacttcgc 24300
atatcccgct gtcaacctgc cccctaaagt catgacggcg gtcatggacc agttactcat 24360
taagcgcgca agtccccttt cagaagacat gcatgaccca gatgcctgtg atgagggtaa 24420
accagtggtc agtgatgagc agctaacccg atggctgggc accgactctc ccagggattt 24480
ggaagagcgt cgcaagctta tgatggccgt ggtgctggtt accgtagaac tagagtgtct 24540
ccgacgtttc tttaccgatt cagaaacctt gcgcaaactc gaagagaatc tgcactacac 24600
ttttagacac ggctttgtgc ggcaggcatg caagatatct aacgtggaac tcaccaacct 24660
ggtttcctac atgggtattc tgcatgagaa tcgcctagga caaagcgtgc tgcacagcac 24720
cctgaagggg gaagcccgcc gtgattacat ccgcgattgt gtctatctgt acctgtgcca 24780
cacgtggcaa accggcatgg gtgtatggca gcaatgttta gaagaacaga acttgaaaga 24840
gcttgacaag ctcttacaga aatctcttaa ggttctgtgg acagggttcg acgagcgcac 24900
cgtcgcttcc gacctggcag acctcatctt cccagagcgt ctcagggtta ctttgcgaaa 24960
cggattgcct gactttatga gccagagcat gcttaacaat tttcgctctt tcatcctgga 25020
acgctccggt atcctgcccg ccacctgctg cgcactgccc tccgactttg tgcctctcac 25080
ctaccgcgag tgccccccgc cgctatggag tcactgctac ctgttccgtc tggccaacta 25140
tctctcctac cactcggatg tgatcgagga tgtgagcgga gacggcttgc tggagtgtca 25200
ctgccgctgc aatctgtgca cgccccaccg gtccctagct tgcaaccccc agttgatgag 25260
cgaaacccag ataataggca cctttgaatt gcaaggcccc agcagccaag gcgatgggtc 25320
ttctcctggg caaagtttaa aactgacccc gggactgtgg acctccgcct acttgcgcaa 25380
gtttgctccg gaagattacc acccctatga aatcaagttc tatgaggacc aatcacagcc 25440
tccaaaggcc gaactttcgg cctgcgtcat cacccagggg gcaattctgg cccaattgca 25500
agccatccaa aaatcccgcc aagaatttct actgaaaaag ggtaaggggg tctaccttga 25560
cccccagacc ggcgaggaac tcaacacaag gttccctcag gatgtcccaa cgacgagaaa 25620
acaagaagtt gaaggtgcag ccgccgcccc cagaagatat ggaggaagat tgggacagtc 25680
aggcagagga ggcggaggag gacagtctgg aggacagtct ggaggaagac agtttggagg 25740
aggaaaacga ggaggcagag gaggtggaag aagtaaccgc cgacaaacag ttatcctcgg 25800
ctgcggagac aagcaacagc gctaccatct ccgctccgag tcgaggaacc cggcggcgtc 25860
ccagcagtag atgggacgag accggacgct tcccgaaccc aaccagcgct tccaagaccg 25920
gtaagaagga tcggcaggga tacaagtcct ggcgggggca taagaatgcc atcatctcct 25980
gcttgcatga gtgcgggggc aacatatcct tcacgcggcg ctacttgcta ttccaccatg 26040
gggtgaactt tccgcgcaat gttttgcatt actaccgtca cctccacagc ccctactata 26100
gccagcaaat cccggcagtc tcgacagata aagacagcgg cggcgacctc caacagaaaa 26160
ccagcagcgg cagttagaaa atacacaaca agtgcagcaa caggaggatt aaagattaca 26220
gccaacgagc cagcgcaaac ccgagagtta agaaatcgga tctttccaac cctgtatgcc 26280
atcttccagc agagtcgggg tcaagagcag gaactgaaaa taaaaaaccg atctctgcgt 26340
tcgctcacca gaagttgttt gtatcacaag agcgaagatc aacttcagcg cactctcgag 26400
gacgccgagg ctctcttcaa caagtactgc gcgctgactc ttaaagagta ggcagcgacc 26460
gcgcttattc aaaaaaggcg ggaattacat catcctcgac atgagtaaag aaattcccac 26520
gccttacatg tggagttatc aaccccaaat gggattggcg gcaggcgcct cccaggacta 26580
ctccacccgc atgaattggc tcagcgccgg gccttctatg atttctcgag ttaatgatat 26640
acgcgcctac cgaaaccaaa tacttttgga acagtcagct cttaccacca cgccccgcca 26700
acaccttaat cccagaaatt ggcccgccgc cctagtgtac caggaaagtc ccgctcccac 26760
cactgtatta cttcctcgag acgcccaggc cgaagtccaa atgactaatg caggtgcgca 26820
gttagctggc ggctccaccc tatgtcgtca caggcctcgg cataatataa aacgcctgat 26880
gatcagaggc cgaggtatcc agctcaacga cgagtcggtg agctctccgc ttggtctacg 26940
accagacgga atctttcaga ttgccggctg cgggagatct tccttcaccc ctcgtcaggc 27000
tgttctgact ttggaaagtt cgtcttcgca accccgctcg ggcggaatcg ggaccgttca 27060
atttgtggag gagtttactc cctctgtcta cttcaacccc ttctccggat ctcctgggca 27120
ttacccggac gagttcatac cgaacttcga cgcgattagc gagtcagtgg acggctacga 27180
ttgatgtctg gtgacgcggc tgagctatct cggctgcgac atctagacca ctgccgccgc 27240
tttcgctgct ttgcccggga actcattgag ttcatctact tcgaactccc caaggatcac 27300
cctcaaggtc cggcccacgg agtgcggatt tctatcgaag gcaaaataga ctctcgcctg 27360
caacgaattt tctcccagcg gcccgtgctg atcgagcgag accagggaaa caccacggtt 27420
tccatctact gcatttgtaa tcaccccgga ttgcatgaaa gcctttgctg tcttatgtgt 27480
actgagttta ataaaaactg aattaagact ctcctacgga ctgccgcttc ttcaacccgg 27540
attttacaac cagaagaacg aaacttttcc tgtcgtccag gactctgtta acttcacctt 27600
tcctactcac aaactagaag ctcaacgact acaccgcttt tccagaagca ttttccctac 27660
taatactact ttcaaaaccg gaggtgagct ccaaggtctt cctacagaaa acccttgggt 27720
ggaagcgggc cttgtagtgc taggaattct tgcgggtggg cttgtgatta ttctttgcta 27780
cctatacaca ccttgcttca ctttcttagt ggtgttgtgg tattggttta aaaaatgggg 27840
cccatactag tcttgcttgt tttactttcg cttttggaac cgggttctgc caattacgat 27900
ccatgtctag acttcgaccc agaaaactgc acacttactt ttgcacccga cacaagccgc 27960
atctgtggag ttcttattaa gtgcggatgg gaatgcaggt ccgttgaaat tacacacaat 28020
aacaaaacct ggaacaatac cttatccacc acatgggagc caggagttcc cgagtggtac 28080
actgtctctg tccgaggtcc tgacggttcc atccgcatta gtaacaacac tttcattttt 28140
tctgaaatgt gcgatctggc catgttcatg agcaaacagt attctctatg gcctcctagc 28200
aaggacaaca tcgtaacgtt ctccattgct tattgcttgt gcgcttgcct tcttactgct 28260
ttactgtgcg tatgcataca cctgcttgta accactcgca tcaaaaacgc caataacaaa 28320
gaaaaaatgc cttaacctct ttctgtttac agacatggct tctcttacat ctctcatatt 28380
tgtcagcatt gtcactgccg ctcatggaca aacagtcgtc tctatccctc taggacataa 28440
ttacactctc ataggacccc caatcacttc agaggtcatc tggaccaaac tgggaagcgt 28500
tgattacttt gatataatct gcaacaaaac aaaaccaata atagtaactt gcaacataca 28560
aaatcttaca ttgattaatg ttagcaaagt ttacagcggt tactattatg gttatgacag 28620
atacagtagt caatatagaa attacttggt tcgtgttacc cagttgaaaa ccacgaaaat 28680
gccaaatatg gcaaagattc gatccgatga caattctcta gaaactttta catctcccac 28740
cacacccgac gaaaaaaaca tcccagattc aatgattgca attgttgcag cggtggcagt 28800
ggtgatggca ctaataataa tatgcatgct tttatatgct tgtcgctaca aaaagtttca 28860
tcctaaaaaa caagatctcc tactaaggct taacatttaa tttcttttta tacagccatg 28920
gtttccacta ccacattcct tatgcttact agtctcgcaa ctctgacttc tgctcgctca 28980
cacctcactg taactatagg ctcaaactgc acactaaaag gacctcaagg tggtcatgtc 29040
ttttggtgga gaatatatga caatggatgg tttacaaaac catgtgacca acctggtaga 29100
tttttctgca acggcagaga cctaaccatt atcaacgtga cagcaaatga caaaggcttc 29160
tattatggaa ccgactataa aagtagttta gattataaca ttattgtact gccatctacc 29220
actccagcac cccgcacaac tactttctct agcagcagtg tcgctaacaa tacaatttcc 29280
aatccaacct ttgccgcgct tttaaaacgc actgtgaata attctacaac ttcacataca 29340
acaatttcca cttcaacaat cagcattatc gctgcagtga caattggaat atctattctt 29400
gtttttacca taacctacta cgcctgctgc tatagaaaag acaaacataa aggtgatcca 29460
ttacttagat ttgatattta atttgttctt ttttttttta tttacagtat ggtgaacacc 29520
aatcatggta cctagaaatt tcttcttcac catactcatt tgtgcattta atgtttgcgc 29580
tactttcaca gcagtagcca cagcaacccc agactgtata ggagcatttg cttcctatgc 29640
actttttgct tttgttactt gcatctgcgt atgtagcata gtctgcctgg ttattaattt 29700
tttccaactt atagactgga tccttgtgcg aattgcctac ctgcgccacc atcccgaata 29760
ccgcaaccaa aatatcgcgg cacttcttag actcatctaa aaccatgcag gctatactac 29820
caatattttt gcttctattg cttccctacg ctgtctcaac cccagctgcc tatagtactc 29880
caccagaaca ccttagaaaa tgcaaattcc aacaaccgtg gtcatttctt gcttgctatc 29940
gagaaaaatc agaaattccc ccaaatttaa taatgattgc tggaataatt aatataatct 30000
gttgcaccat aatttcattt ttgatatacc ccctatttga ttttggctgg aatgctccca 30060
atgcacatga tcatccacaa gacccagagg aacacattcc cctacaaaac atgcaacatc 30120
caatagcgct aatagattac gaaagtgaac cacaaccccc actactccct gctattagtt 30180
acttcaacct aaccggcgga gatgactgaa acactcacca cctccaattc cgccgaggat 30240
ctgctcgata tggacggccg cgtctcagaa cagcgactcg cccaactacg catccgccag 30300
cagcaggaac gcgcggccaa agagctcaga gatgtcatcc aaattcacca atgcaaaaaa 30360
ggcatattct gtttggtaaa acaagccaag atatcctacg agatcaccgc tactgaccat 30420
cgcctctctt acgaacttgg cccccaacga caaaaattta cctgcatggt gggaatcaac 30480
cccatagtta tcacccagca aagtggagat actaagggtt gcattcactg ctcctgcgat 30540
tccatcgagt gcacctacac cctgctgaag accctatacg gcctaagaga cctgctacca 30600
atgaattaaa aaatgattaa taaaaaatca cttacttgaa atcagcaata aggtctctgt 30660
tgaaattttc tcccagcagc acctcacttc cctcttccca actctggtat tctaaacccc 30720
gttcagcggc atactttctc catactttaa aggggatgtc aaattttagc tcctctcctg 30780
tacccacaat cttcatgtct ttcttcccag atgaccaaga gagtccggct cagtgactcc 30840
ttcaaccctg tctaccccta tgaagatgaa agcacctccc aacacccctt tataaaccca 30900
gggtttattt ccccaaatgg cttcacacaa agcccaaacg gagttcttac tttaaaatgt 30960
ttaaccccac taacaaccac aggcggatct ctacagctaa aagtgggagg gggacttaca 31020
gtggatgaca ccaacggttt tttgaaagaa aacataagtg ccaccacacc actcgttaag 31080
actggtcact ctataggttt accactagga gccggattgg gaacgaatga aaataaactt 31140
tgtatcaaat taggacaagg acttacattc aattcaaaca acatttgcat tgatgacaat 31200
attaacacct tatggacagg agtcaacccc accgaagcca actgtcaaat catgaactcc 31260
agtgaatcta atgattgcaa attaattcta acactagtta aaactggagc actagtcact 31320
gcatttgttt atgttatagg agtatctaac aattttaata tgctaactac acacagaaat 31380
ataaatttta ctgcagagct gtttttcgat tctactggta atttactaac tagactctca 31440
tccctcaaaa ctccacttaa tcataaatca ggacaaaaca tggctactgg tgccattact 31500
aatgctaaag gtttcatgcc cagcacgact gcctatcctt tcaatgataa ttctagagaa 31560
aaagaaaact acatttacgg aacttgttac tacacagcta gtgatcgcac tgcttttccc 31620
attgacatat ctgtcatgct taaccgaaga gcaataaatg acgagacatc atattgtatt 31680
cgtataactt ggtcctggaa cacaggagat gccccagagg tgcaaacctc tgctacaacc 31740
ctagtcacct ccccatttac cttttactac atcagagaag acgactgaca aataaagttt 31800
aacttgttta tttgaaaatc aattcacaaa atccgagtag ttattttgcc tcccccttcc 31860
catttaacag aatacaccaa tctctcccca cgcacagctt taaacatttg gataccatta 31920
gatatagaca tggttttaga ttccacattc caaacagttt cagagcgagc caatctgggg 31980
tcagtgatag ataaaaatcc atcgggatag tcttttaaag cgctttcaca gtccaactgc 32040
tgcggatgcg actccggagt ctggatcacg gtcatctgga agaagaacga tgggaatcat 32100
aatccgaaaa cggtatcgga cgattgtgtc tcatcaaacc cacaagcagc cgctgtctgc 32160
gtcgctccgt gcgactgctg tttatgggat cagggtccac agtgtcctga agcatgattt 32220
taatagccct taacatcaac tttctggtgc gatgcgcgca gcaacgcatt ctgatttcac 32280
tcaaatcttt gcagtaggta caacacatta ttacaatatt gtttaataaa ccataattaa 32340
aagcgctcca gccaaaactc atatctgata taatcgcccc tgcatgacca tcataccaaa 32400
gtttaatata aattaaatga cgttccctca aaaacacact acccacatac atgatctctt 32460
ttggcatgtg catattaaca atctgtctgt accatggaca acgttggtta atcatgcaac 32520
ccaatataac cttccggaac cacactgcca acaccgctcc cccagccatg cattgaagtg 32580
aaccctgctg attacaatga caatgaagaa cccaattctc tcgaccgtga atcacttgag 32640
aatgaaaaat atctatagtg gcacaacata gacataaatg catgcatctt ctcataattt 32700
ttaactcctc aggatttaga aacatatccc agggaatagg aagctcttgc agaacagtaa 32760
agctggcaga acaaggaaga ccacgaacac aacttacact atgcatagtc atagtatcac 32820
aatctggcaa cagcgggtgg tcttcagtca tagaagctcg ggtttcattt tcctcacaac 32880
gtggtaactg ggctctggtg taagggtgat gtctggcgca tgatgtcgag cgtgcgcgca 32940
accttgtcat aatggagttg cttcctgaca ttctcgtatt ttgtatagca aaacgcggcc 33000
ctggcagaac acactcttct tcgccttcta tcctgccgct tagcgtgttc cgtgtgatag 33060
ttcaagtaca accacactct taagttggtc aaaagaatgc tggcttcagt tgtaatcaaa 33120
actccatcgc atctaatcgt tctgaggaaa tcatccacgg tagcatatgc aaatcccaac 33180
caagcaatgc aactggattg tgtttcaagc aggagaggag agggaagaga cggaagaacc 33240
atgttaattt ttattccaaa cgatctcgca gtacttcaaa ttgtagatcg cgcagatggc 33300
atctctcgcc cccactgtgt tggtgaaaaa gcacagctag atcaaaagaa atgcgatttt 33360
caaggtgctc aacggtggct tccagcaaag cctccacgcg cacatccaag aacaaaagaa 33420
taccaaaaga aggagcattt tctaactcct caatcatcat attacattcc tgcaccattc 33480
ccagataatt ttcagctttc cagccttgaa ttattcgtgt cagttcttgt ggtaaatcca 33540
atccacacat tacaaacagg tcccggaggg cgccctccac caccattctt aaacacaccc 33600
tcataatgac aaaatatctt gctcctgtgt cacctgtagc gaattgagaa tggcaacatc 33660
aattgacatg cccttggctc taagttcttc tttaagttct agttgtaaaa actctctcat 33720
attatcacca aactgcttag ccagaagccc cccgggaaca agagcagggg acgctacagt 33780
gcagtacaag cgcagacctc cccaattggc tccagcaaaa acaagattgg aataagcata 33840
ttgggaaccg ccagtaatat catcgaagtt gctggaaata taataaggca gagtttcttg 33900
taaaaattga ataaaagaaa aatttgccaa aaaaacattc aaaacctctg ggatgcaaat 33960
gcaataggtt accgcgctgc gctccaacat tgttagtttt gaattagtct gcaaaaataa 34020
aaaaaaaaac aagcgtcata tcatagtagc ctgacgaaca gatggataaa tcagtctttc 34080
catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt catcatgatt 34140
aaacaacagc accgaaagtt cctcgcggtg accagcatga ataattcttg atgaagcata 34200
caatccagac atgttagcat cagttaacga gaaaaaacag ccaacatagc ctttgggtat 34260
aattatgctt aatcgtaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34320
aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgtcg cccccggtcc 34380
ctctaaatac acatacaaag cctcatcagc catggcttac cagacaaagt acagcgggca 34440
cacaaagcac aagctctaaa gtgactctcc aacctctcca caatatatat atacacaagc 34500
cctaaactga cgtaatggga gtaaagtgta aaaaatcccg ccaaacccaa cacacacccc 34560
gaaactgcgt caccagggaa aagtacagtt tcacttccgc aatcccaaca ggcgtaactt 34620
cctctttctc acggtacgtg atatcccact aacttgcaac gtcattttcc cacggtcgca 34680
ccgccccttt tagccgttaa ccccacagcc aatcaccaca cgatccacac tttttaaaat 34740
cacctcattt acatattggc accattccat ctataaggta tattattgat gatg 34794
<210> 139
<211> 35343
<212> DNA
<213> 人3型腺病毒（Human adenovirus type 3）
<400> 139
ctatctatat aatatacctt atagatggaa tggtgccaac atgtaaatga ggtaatttaa 60
aaaagtgcgc gctgtgtggt gattggctgc ggggttaacg gctaaaaggg gcggcgcgac 120
cgtgggaaaa tgacgtgact tatgtgggag gagttatgtt gcaagttatt acggtaaatg 180
tgacgtaaaa cgaggtgtgg tttgaacacg gaagtagaca gttttcccac gcttactgac 240
aggatatgag gtagttttgg gcggatgcaa gtgaaaattc tccattttcg cgcgaaaact 300
aaatgaggaa gtgaatttct gagtcatttc gcggttatgc cagggtggag tatttgccga 360
gggccgagta gactttgacc gtttacgtgg aggtttcgat taccgtgttt ttcacctaaa 420
tttccgcgta cggtgtcaaa gttctgtgtt tttacgtagg tgtcagctga tcgctagggt 480
atttaaacct gacgagttcc gtcaagaggc cactcttgag tgccagcgag aagagttttc 540
tcctccgcgc cgcaagtcag ttctgcgctt tgaaaatgag acacctgcgc ttcctgccac 600
aggaggttat ctccagtgag accgggatcg aaatactgga gtttgtggta aataccctaa 660
tgggagacga cccggaaccg ccagtgcagc ctttcgatcc acctacgctg cacgatctgt 720
atgatttaga gatagacggg ccggaggatc ccaatgagga agctgtgaat gggtttttta 780
ctgattctat gctgctagct gctgatgaag gattggacat aaaccctcct cctgagacac 840
ttgttacccc aggggtggtt gtggaaagcg gcataggtgg gaaaaaattg cctgatctgg 900
gagcagctga aatggacttg cgttgttatg aagagggttt tcctcccagt gatgatgaag 960
atggggaaac tgagcagtcc atccataccg cagtaaatga gggagtaaaa gctgccagcg 1020
atgtttttaa gttggactgt ccggagctgc ctggacatgg ctgtaagtct tgtgaatttc 1080
acaggaataa cactggaatg aaagaactat tgtgctcgct ttgctatatg agaatgcact 1140
gccactttat ttacagtaag tgtatttaag tgaaatttaa aggaatagtg tagctattta 1200
ataactgttg aatggtagat ttatgttttt ttcttgcgat tttttgtagg tcctgtgtct 1260
gatgatgagt caccttctcc tgattcaact acctcacctc ctgaaattca ggcgcccgca 1320
cctgcaaacg tatgcaagcc cattcctgtg aagcctaagc ctgggaaacg ccctgctgtg 1380
gataagcttg aggacttgtt ggagggtggg gatggacctt tggaccttag tacccggaaa 1440
ctgccaaggc aatgagtgcc ctgcagctgt gtttatttaa tgtgacgtca tgtaataaaa 1500
ttatgtcagc tgctgagtgt tttattactt cttgggtggg gacttggata tataagtagg 1560
agcagatctg tgtggttagc tcacagcaac ctgctgccat ccatggaggt ttgggctatc 1620
ttggaagacc tcagacagac taagctactg ctagaaaacg cctcggacgg agtctctggc 1680
ctttggagat tctggttcgg tggtgatcta gctaggctag tgtttaggat aaaacaggac 1740
tacagggaag aatttgaaaa gttattggac gatagtccgg gactttttga agctcttaac 1800
ttgggtcatc aggctcattt taaggagaag gttttatcag ttttagattt ttctactcct 1860
ggtagaactg ctgctgctgt agcttttctt acttttatat tggataaatg gatccgccaa 1920
actcacttca gcaagggata cgttttggat ttcatagcag cagctttgtg gagaacatgg 1980
aaggctcgca ggatgaggac aatcttagat tactggccag tgcagcctct gggagtagca 2040
gggatactga gacacccacc gaccatgcca gcggttctgc aggaggagca gcaggaggac 2100
aatccgagag ccggcctgga ccctccggtg gaggagtagc tgacctgttt cctgaactgc 2160
gacgggtgct tactaggtct acgaccagtg gacagaacag gggaattaag agggagagga 2220
atcctagtgg gaataattca agaaccgagt tggctttaag tttaatgagc cgcaggcgtc 2280
ctgaaactgt ttggtggcat gaggttcaga gcgaaggcag ggatgaagtt tcaatattgc 2340
aggagaaata ttcactagaa caacttaaga cctgttggtt ggaacctgag gatgattggg 2400
aggtggccat taggaattat gctaagatat ctctgaggcc tgataaacaa tatagaatta 2460
ctaagaagat taatattaga aatgcatgct acatatcagg gaatggggca gaggttataa 2520
tagatacaca agataaagca gtttttagat gttgtatgat gggtatgtgg ccaggggttg 2580
tcggcatgga agcagtaaca cttatgaata ttaggtttaa aggggatggg tataatggca 2640
ttgtatttat ggctaacact aagctgattc tacatggttg tagctttttt gggtttaata 2700
atacgtgtgt agaagcttgg gggcaagtta gtgtgagggg ttgtagtttt tatgcatgct 2760
ggattgcaac atcaggtagg gtcaagagtc agttgtctgt gaagaaatgc atgtttgaga 2820
gatgtaatct tggcatactg aatgaaggtg aagcaagggt ccgccactgc gcagctacag 2880
aaactggctg cttcattcta ataaagggaa atgccagtgt gaagcataat atgatctgtg 2940
gacattcgga tgagaggcct tatcagatgc tgacctgcgc tggtggacat tgcaatattc 3000
ttgctaccgt gcatatcgtt tcacatgcac gcaaaaaatg gcctgtattt gaacataatg 3060
tgattaccaa gtgcaccatg cacataggtg gtcgcagggg aatgtttatg ccttaccagt 3120
gtaacatgaa tcatgtgaag gtaatgttgg aaccagatgc cttttccaga gtgagcttaa 3180
caggaatctt tgatatgaat attcaactat ggaagatcct gagatatgat gacactaaac 3240
caagggtgcg cgcatgcgaa tgcggaggca agcatgctag attccagccg gtgtgcgtgg 3300
atgtgactga agacttgaga cccgatcatt tggtgcttgc ctgcactgga gcggagttcg 3360
gttctagtgg tgaagaaact gactaaagtg agtagtgggg caagatgtgg atggggactt 3420
tcaggttggt aaggtgggca gattgggtaa attttgttaa tttctgtctt gcagctgcca 3480
tgagtggaag cgcttctttt gaggggggag tatttagccc ttatctgacg ggcaggctcc 3540
caccatgggc aggagttcgt cagaatgtca tgggatccac tgtggatggg agacccgtcc 3600
agcccgccaa ttcctcaacg ctgacctatg ccactttgag ttcgtcacca ttggatgcag 3660
ctgcagccgc cgccgctact gctgccgcca acaccatcct tggaatgggc tattatggaa 3720
gcatcgttgc caattccagt tcctctaata acccttcaac cctggctgag gacaagctac 3780
ttgttctctt ggcgcagctc gaggccttaa cccaacgctt aggcgaactg tctaagcagg 3840
tggcccagtt gcgtgagcaa actgagtctg ctgttgccac agcaaagtct aaataaagat 3900
ctcaaatcaa taaataaaga aatacttgat ataaaacaaa tgaatgttta tttgattttt 3960
cgcgcgcggt atgccctgga ccatcggtct cgatcattga gaacgcggtg gatcttttcc 4020
agtaccctgt aaaggtggga ttgaatgttt agatacatgg gcattagtcc gtctcggggg 4080
tggagatagc tccattgaag agcctcttgc tccggggtag tgttataaat cacccagtca 4140
tagcaaggtc ggagtgcatg gtgttgcaca atatctttta ggagcagact aattgcaacg 4200
gggaggccct tagtgtaggt gtttacaaat ctgttgagct gggacgggtg catccggggt 4260
gaaattatat gcattttgga ctggatcttg aggttggcaa tgttgccgcc tagatcccgt 4320
ctcgggttca tattgtgcag gaccaccaag acagtgtatc cggtgcactt gggaaattta 4380
tcatgcagct tagagggaaa agcatgaaaa aatttggaga cgcctttgtg accccccaga 4440
ttctccatgc actcatccat aatgatagcg atggggccgt gggcagcggc acgggcgaac 4500
acgttccggg ggtctgaaac atcatagtta tgctcctgag tcaggtcatc ataagccatt 4560
ttaataaact ttgggcggag ggtgccagat tgggggatga aagttccctc tggcccggga 4620
gcatagtttc cctcacatat ttgcatttcc caggctttca gttcagaggg ggggatcatg 4680
tccacctgcg gggctataaa aaataccgtt tctggagccg gggtgattaa ctgggacgag 4740
agcaaattcc taagcagctg agacttgccg cacccagtgg gaccgtaaat gaccccaatt 4800
acgggttgca gatggtagtt tagggaacga cagctgccgt cctcccggag caggggggcc 4860
acttcgttca tcatttccct tacatggata ttttcccgca ccaagtccgt taggaggcgc 4920
tctcccccaa gggatagaag ctcctggagc gaggagaagt ttttcagcgg cttcagcccg 4980
tcagccatgg gcattttgga aagagtctgt tgcaagagct cgagccggtc ccagagctcg 5040
gtgatgtgct ctatggcatc tcgatccagc agacctcctc gtttcgcggg ttgggacggc 5100
tcctggagta gggaatcaga cgatgggcgt ccagcgctgc cagggtccga tccttccatg 5160
gtcgcagcgt ccgagtcagg gttgtttccg tcacggtgaa ggggtgcgcg cctggttggg 5220
cgcttgcgag ggtgcgcttc agactcatcc tgctggtcga gaaccgctgc cgattggcgc 5280
cctgcatgtc ggccaggtag cagtttacca tgagttcgta gttgagcgcc tcggccgcgt 5340
ggcctttggc acggagctta cctttggaag ttttatggca ggcggggcag tagatacatt 5400
tgagggcata caacttgggc gcgaggaaaa tggattcggg ggagtatgca tccgcaccgc 5460
aggaggcgca gacggtttcg cactccacga gccaggtcag atccggctca tcggggtcaa 5520
aaacaagttt tccgccatgt tttttgatgc gtttcttacc tttggtttcc atgagttcgt 5580
gtccccgctg ggtgacaaag aggctgtccg tgtccccgta gaccgacttt atgggcctgt 5640
cctcgagcgg agtgcctcgg tcctcttcgt agaggaaccc agcccactct gatacaaaag 5700
cgcgtgtcca ggccagcaca aaggaggcca cgtgggaggg gtagcggtcg ttgtcaacca 5760
gggggtccac cttctctacg gtatgtaaac acatgtcccc ctcctccaca tccaagaatg 5820
tgattggctt gtaagtgtag gccacgtgac caggggtccc cgccgggggg gtataaaagg 5880
gggcgggcct ctgttcgtcc tcactgtctt ccggatcgct gtccaggagc gccagctgtt 5940
ggggtaggta ttccctctcg aaggcgggca tgacctctgc actcaggttg tcagtttcta 6000
ggaacgagga ggatttgata ttgacagtac cagcagagat gcctttcata agactctcgt 6060
ccatctggtc agaaaacaca atcttcttgt tgtccagctt ggtggcaaat gatccataga 6120
gggcattgga tagaagcttg gcgatggagc gcatggtttg gttcttttcc ttgtccgcgc 6180
gctccttggc ggtgatgtta agctggacgt actcgcgcgc cacacatttc cattcaggaa 6240
agatggttgt cagttcatcc ggaactattc tgattcgcca tcccctattg tgcagggtta 6300
tcagatccac actggtggcc acctcgcctc ggaggggctc attggtccag cagagtcgac 6360
ctccttttct tgaacagaaa ggggggaggg ggtctagcat gaactcatca ggggggtccg 6420
catctatggt aaatattccc ggtagcaaat ctttgtcaaa atagctgatg gtggcgggat 6480
catccaaggt catctgccat tctcgaactg ccagcgcgcg ctcatagggg ttaagagggg 6540
tgccccaggg catggggtgg gtgagcgcgg aggcatacat gccacagata tcgtagacat 6600
agaggggctc ttcgaggatg ccgatgtaag tgggataaca tcgcccccct ctgatgcttg 6660
ctcgcacata gtcatagagt tcatgtgagg gggcaagaag acccgggccc agattggtgc 6720
ggttgggttt ttccgccctg taaacgatct ggcgaaagat ggcatgggaa ttggaagaga 6780
tagtaggtct ctggaatatg ttaaaatggg catgaggtaa gcctacagag tcccttatga 6840
agtgggcata tgactcttgc agcttggcta ccagctcggc ggtgatgagt acatccaggg 6900
cacagtagtc gagagtttcc tggatgatgt cataacgcgg ttggcttttc ttttcccaca 6960
gctcgcggtt gagaaggtat tcttcgtgat ccttccagta ctcttcgagg ggaaacccgt 7020
ctttttctgc acggtaagag cccaacatgt agaactgatt gactgccttg tagggacagc 7080
atcccttctc cactgggaga gagtatgctt gggctgcatt gcgcagcgag gtatgagtga 7140
gggcaaaagt gtccctgacc atgactttga ggaattgata cttgaagtcg atgtcatcac 7200
aggccccctg ttcccagagt tggaagtcca cccgcttctt gtaggcgggg ttgggcaaag 7260
cgaaagtaac atcattgaag aggatcttgc cggccctggg catgaaattt cgggtgattt 7320
tgaaaggctg aggaacctct gctcggttat tgataacctg agcggccaag acgatctcat 7380
caaagccatt gatgttgtgc cccactatgt acagttctaa gaatcgaggg gtgcccctga 7440
catgaggcag cttcttgagt tcttcaaaag tgagatctgt agggtcagtg agagcatagt 7500
gttcgagggc ccattcgtgc acgtgagggt tcgctttaag gaaggaggac cagaggtcca 7560
ctgccagtgc tgtttgtaac tggtcccggt actgacgaaa atgctgtccg actgccatct 7620
tttctggggt gacgcaatag aaggtttggg ggtcctgccg ccagcgatcc cacttgagtt 7680
ttatggcgag gtcataggcg atgttgacga gccgctggtc tccagagagt ttcatgacca 7740
gcatgaaggg gattagctgc ttgccaaagg accccatcca ggtgtaggtt tccacatcgt 7800
aggtgagaaa gagcctttct gtgcgaggat gagagccaat cgggaagaac tggatctcct 7860
gccaccagtt ggaggaatgg ctgttgatgt gatggaagta gaactccctg cgacgcgccg 7920
agcattcatg cttgtgcttg tacagacggc cgcagtactc gcagcgattc acgggatgca 7980
ccttatgaat gagttgtacc tgacttcctt tgacgagaaa tttcagtgga aaattgaggc 8040
ctggcgcttg tacctcgcgc tttactatgt tgtctgcatc ggcatgacca tcttctgtct 8100
cgatggtggt catgctgacg agccctcgcg ggaggcaagt ccagacctcg gcgcggcagg 8160
ggcggagctc gaggacgaga gcgcgcaggc cggagctgtc cagggtcctg agacgctgcg 8220
gagtcaggtt agtaggcagt gtcaggagat taacttgcat gatcttttgg agggcgtgag 8280
ggaggttcag atagtacttg atctcaacgg gtccgttggt ggagatgtcg atggcttgca 8340
gggttccgtg tcccttgggc gctaccaccg tgcccttgtt tttcattttg gacggcggtg 8400
gctctgttgc ttcttgcatg tttagaagcg gtgtcgaggg cgcgcaccgg gcggcagggg 8460
cggctcggga cccggcggca tggctggcag tggtacgtcg gcgccgcgcg cgggtaggtt 8520
ctggtactgc gccctgagaa gactcgcatg cgcgacgacg cggcggttga catcctggat 8580
ctgacgcctc tgggtgaaag ctaccggccc cgtgagcttg aacctgaaag agagttcaac 8640
agaatcaatc tcggtatcgt tgacggcggc ttgcctaagg atttcttgca cgtcgccaga 8700
gttgtcctgg taggcgatct cggccatgaa ctgctcgatc tcttcctctt gaagatctcc 8760
gcggcccgct ctctcgacgg tggccgcgag gtcgttggag atgcgcccaa tgagttgaga 8820
gaatgcattc atgcccgcct cgttccagac gcggctgtag accacagccc ccacgggatc 8880
tctcgcgcgc atgaccacct gggcgaggtt gagctccacg tggcgggtga agaccgcata 8940
gttgcatagg cgctggaaaa ggtagttgag tgtggtggcg atgtgctcgg tgacgaagaa 9000
atacatgatc catcgtctca gcggcatctc gctgacatcg cccagcgctt ccaagcgctc 9060
catggcctcg tagaagtcca cggcaaagtt aaaaaactgg gagttacgcg cggacacggt 9120
caactcctct tccagaagac ggataagttc ggcgatggtg gtgcgcacct cgcgctcgaa 9180
agcccctggg atttcttcct caatctcttc ttcttccact aacatctctt cctcttcagg 9240
tggggctgca ggaggagggg gaacgcggcg acgccggcgg cgcacgggca gacggtcgat 9300
gaatctttca atgacctctc cgcggcggcg gcgcatggtc tcggtgacgg cacgaccgtt 9360
ctccctgggt ctcagagtga agacgcctcc gcgcatctcc ctgaagtggt gactgggagg 9420
ctctccgttg ggcagggaca ccgcgctgat tatgcatttt atcaattgcc ccgtaggtac 9480
tccgcgcaag gacctgatcg tctcaagatc cacgggatct gaaaaccttt cgacgaaagc 9540
gtctaaccag tcgcaatcgc aaggtaggct gagcactgtt tcttgcgggc gggggcggct 9600
agacgctcgg tcggggttct ctctttcttc tccttcctcc tcttgggagg gtgagacgat 9660
gctgctggtg atgaaattaa aataggcagt tttgagacgg cggatggtgg cgaggagcac 9720
caggtctttg ggtccggctt gttggatacg caggcgatga gccattcccc aagcattatc 9780
ctgacatctg gccagatctt tatagtagtc ttgcatgagt cgttccacgg gcacttcttc 9840
ttcgcccgct ctgccatgca tgcgagtgat cccgaacccg cgcatgggct ggacaagtgc 9900
caggtccgct acaacccttt cggcgaggat ggcttgctgc acctgggtga gggtggcttg 9960
gaagtcgtca aagtccacga agcggtggta ggccccggtg ttgattgtgt aggagcagtt 10020
ggccatgact gaccagttga ctgtctggtg cccagggcgc acgagctcgg tgtacttgag 10080
gcgcgagtat gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca ggtactggta 10140
gccaatgaga aagtgtggcg gtggctggcg gtacaggggc catcgctctg tagccggggc 10200
tccgggggcg aggtcttcca gcatgaggcg gtggtagccg tagatgtacc tggacatcca 10260
ggtgataccg gaggcggtgg tggatgcacg tgggaactcg cgcacgcggt tccagatgtt 10320
gcgcagcggc atgaagtagt tcatggtagg cacggtctgg ccagtgaggc gcgcgcagtc 10380
attgacgctc tgtagacacg gagaaaacga aagcgatgag cggctcgact ccgtggtctg 10440
ggggaacgtg aacgggttgg gtcgcggtgt accccggttc gagtccaaag ctaagcgatc 10500
acgctcggat cggccggagc cgcggctaac gtggtattgg ctatcccgtc tcgacccagc 10560
cgacgaatat ccagggtacg gagtagagtc gtttttgctg ctttttcctg gacgtgtgcc 10620
attgccacgt caagctttag aacgctcagt tctcgggccg tgagtggctc gcgcccgtag 10680
tctggagaat cagtcgccag ggttgcgttg cggtatgccc cggttggagc ctaagcgcgg 10740
ctcgtatcgg ccggtttccg cgacaagcga gggtttggca gccccgttat ttccaagacc 10800
ccgccagccg acttctccag tttacgggag cgagcccttt tttttttttt tttgtttttg 10860
tcgcccagat gcatccagtg ctgcgacaga tgcgccccca gcaacaggcc ccttctcagc 10920
aacagccaca aaaggctctt cttgctcctg caactactgc agctgcagcc gtgagcggcg 10980
cgggacagcc cgcctatgat ctggacttgg aagagggcga gggattggcg cgcctggggg 11040
ctccatcgcc cgagcggcac ccgcgggtgc aactaaaaaa ggactctcgc gaggcgtacg 11100
tgccccagca gaacctgttc agggacagga gcggcgagga gccagaggag atgcgagcat 11160
ctcgatttaa cgcgggtcgc gagctgcgcc acggtctgga tcgaagacgg gtgctgcaag 11220
acgaggattt tgaggtcgat gaagtcacag ggatcagccc agctagggca catgtggccg 11280
cggccaacct agtctcggcc tacgagcaga ccgtgaagga ggagcgcaac ttccaaaaat 11340
cttttaacaa ccatgtgcgc accctgatcg cccgcgagga agtgaccctg ggtctgatgc 11400
atctgtggga cctgatggag gctatcgccc aaaaccccac tagcaaacca ctgacagctc 11460
agctgtttct ggtggttcaa catagcaggg acaacgaggc attcagggag gcgttgttga 11520
acatcaccga gcctgatggg agatggctgt atgatctgat caacatcctg caaagtatta 11580
tagtgcagga acgtagcctg ggtttggctg agaaagtggc agctatcaac tactcggtct 11640
tgagcctggg caaatactac gctcgcaaga tctacaagac cccctacgta cccatagaca 11700
aggaggtgaa gatagatggg ttttacatgc gcatgactct gaaggtgctg actctgagcg 11760
acgatctggg ggtgtatcgc aatgacagga tgcaccgcgc ggtgagcgcc agcaggaggc 11820
gcgagctgag cgacagagaa cttatgcaca gcttgcaaag agctctaacg ggggccggga 11880
ctgatgggga gaactacttt gacatgggag cggatttgca atggcaaccc agtcgcaggg 11940
ccatggaggc tgcagggtgt gagcttcctt acatagaaga ggtggatgaa gtcgaggacg 12000
aggagggcga gtacttggaa gactgatggc gcgacccgta tttttgctag atggaacagc 12060
agcaggcacc ggaccccgca atgcgggcgg cgctgcagag ccagccgtcc ggcattaact 12120
cctcggacga ttggacccag gccatgcaac gcataatggc gctgacgacc cgcaaccccg 12180
aagcctttag acagcaaccc caggccaacc gcctttctgc catactggag gccgtagtgc 12240
cctcccgctc caaccccacc cacgagaagg tcctggctat cgtgaacgcg ctggtggaga 12300
acaaggccat ccgtcccgat gaggccgggc tggtatacaa tgctctcttg gagcgcgtgg 12360
cccgttacaa cagcagcaac gtgcaaacca acctggaccg gatggtgacc gatgtgcgcg 12420
aggccgtgtc tcagcgcgag cgattccagc gcgacgccaa cttggggtcg ttggtagcgc 12480
taaacgcttt cctcagcacc cagcccgcca acgtgccccg tggtcagcaa gactatacaa 12540
actttttgag tgcattgaga ctcatggtag ctgaggtgcc ccagagcgag gtgtaccagt 12600
ccgggccaga ttacttcttc cagaccagca gacagggctt gcagacagtg aacctgactc 12660
aggctttcaa gaacctgaag ggtctgtggg gagtgcacgc cccagtaggg gatcgcgcga 12720
ccgtgtctag cttgctgact cccaactccc gcctgctgct gctgctggta tcccccttta 12780
ctgacagcgg tagcattgac cgcaactcgt acttgggcta cctgcttaac ctgtatcgcg 12840
aggccatagg acagagccag gtggacgagc agacctatca agaaatcacc caagtgagcc 12900
gcgccctggg tcaggaagac acgggcagtt tggaagccac cctgaacttc ttgctaacca 12960
accggtcaca gaagatccct cctcagtatg cgcttaccgc tgaggaggag cggatcctca 13020
gatacgtgca acagagcgtt ggactgttcc tgatgcagga gggggcgaca cctaccgccg 13080
cgctggacat gacagctcga aacatggagc ccagcatgta tgctagtaac aggcctttca 13140
ttaacaaact gctggactac ctgcacaggg cggccgccat gaactctgat tatttcacca 13200
atgctatcct gaacccacac tggctgcccc cacctggttt ctacactggc gagtacgaca 13260
tgcccgaccc caatgacggg ttcctgtggg acgatgtgga cagcagcata ttttccccgc 13320
ctcccggtta tacagtttgg aagaaggaag ggggcgatag aagacactct tccgtgtcgc 13380
tatccggaac ggctggtgct gccgcgaccg tgcccgaagc tgcaagtcct ttccctagct 13440
tgcccttttc actaaacagc gttcgcagca gtgaactggg gagaataacc cgcccgcgct 13500
tgatgggcga ggatgagtac ttgaatgact ctttgctgag gccagagagg gaaaagaact 13560
tccccaacaa tggaatagag agtctggtgg ataagatgag tagatggaag acctatgcgc 13620
aggatcacag agacgagccc aggatcttgg gggctacaag cagaccgatc cgtagacgcc 13680
agcgccacga caggcagatg ggtcttgtgt gggacgatga ggactctgcc gatgatagca 13740
gcgtgttgga cttgggtgga agaggagggg gcaacccgtt cgctcatctg cgtcccagat 13800
tcgggcgcat gttgtaaaag tgaaagtaaa ataaaaaggc aactcaccaa ggccatggcg 13860
accgagcgtg cgttcgttct tttttgttat ctgtgtctag tacgatgagg agacgagccg 13920
tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcttacgag agcgtgatgc 13980
agcaacaggc ggcgatgata cagcccccac tggaggctcc cttcgtaccc ccacggtacc 14040
tggcgcctac ggaagggaga aacagcattc gttactcgga gctgtcgccc ctgtacgata 14100
ccaccaagtt gtatctggtg gacaacaagt cggcggacat cgcctccctg aactatcaga 14160
acgaccacag caacttcctg accacggtgg tgcagaacaa tgactttacc cccacggagg 14220
ctagcaccca gaccatcaac tttgacgagc ggtcgcgatg gggcggtcag ctgaagacca 14280
tcatgcacac caacatgccc aacgtgaacg agtacatgtt cagcaacaag ttcaaggcga 14340
gggtgatggt gtccagaaaa gctcctgaag gtgttacagt aaatgacacc tatgatcata 14400
aagaggatat cttgaagtat gagtggtttg agttcatttt accagaaggc aacttttcag 14460
ccaccatgac gatcgacctg atgaacaatg ccatcattga caactacctg gaaattggca 14520
gacagaatgg agtgctggaa agtgacattg gtgttaagtt tgacactaga aatttcaggc 14580
tcgggtggga ccccgaaact aagttgatta tgccaggtgt ctacacttat gaggcattcc 14640
atcctgacat tgtattgctg cctggttgcg gggtagactt tactgaaagc cgacttagca 14700
acttgcttgg catcaggaag agacatccat tccaggaggg tttcaaaatc atgtatgaag 14760
atcttgaagg gggtaatatt cctgcccttt tggatgtcac tgcctatgag gaaagcaaaa 14820
aggataccac tactgaaaca accacactgg ctgttgcaga ggaaactagt gaagatgatg 14880
atataactag aggagatacc tatataactg aaaaacaaaa acgtgaagct gcagctgctg 14940
aagttaaaaa agagttaaag atccaacctc tagaaaaaga cagcaagagt agaagctaca 15000
atgtcttgga agacaaaatc aacacagcct accgcagttg gtacctgtcc tacaattacg 15060
gtaaccctga gaaaggaata aggtcttgga cactgctcac cacttcagat gtcacctgtg 15120
gggcagagca ggtctactgg tcgctccctg acatgatgca agacccagtc accttccgct 15180
ccacaagaca agtcaacaac tacccagtgg tgggtgcaga gcttatgccc gtcttctcaa 15240
agagtttcta caatgagcaa gccgtgtact ctcagcagct ccgacaggcc acttcgctca 15300
cgcacgtctt caaccgcttc cctgagaacc agatcctcat ccgcccgccg gcgcccacaa 15360
ttaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggaccctg ccgttacgca 15420
gcagtatccg gggagtccag cgcgtgaccg ttactgacgc cagacgccgc acctgtccct 15480
acgtttacaa ggccctgggc atagtcgcgc cgcgcgttct ttcaagccgc actttctaaa 15540
aaaaaaaaaa atgtccattc tcatctcgcc cagtaataat accggttggg gactgtatgc 15600
gcccaccaag atgtatggag gcgcccgcaa gcgctctacc cagcatcctg tgcgcgttcg 15660
cggtcatttc cgcgctccct ggggcgcact caagggtcgt acccgcactc ggaccacggt 15720
cgatgatgtg atcgaccagg tggtcgccga tgctcgtaat tatactccta ctgcgcctac 15780
atctactgtg gatgcagtta ttgacagtgt ggtggcagac gcccgcgcct atgctcgccg 15840
gaagagccga aggaggcgca tcgccaggcg ccacagggct actcccgcca tgcgagccgc 15900
aaaagctatt ctgcggaggg ccaaacgtgt ggggcgaaga gccatgctta gagcggccag 15960
acgcgcggct tcaggtgcca gcagcggcag gtcccgcagg cgcgcggcca cggcggcagc 16020
agcggccatt gccaacatgg cccaaccgcg aagaggcaat gtgtactggg tgcgtgatgc 16080
cactaccggc cagcgcgtgc ccgtgcgcac ccgcccccct cgcacttaga agatactgag 16140
cagtctccga tgttgtgtcc cagcggcaag tatgtccaag cgcaaataca aggaagagat 16200
gctccaggtc atcgcgcctg aaatctacgg tccgccggtg aaggatgaaa aaaagccccg 16260
caaaatcaag cgggtcaaaa ataacaaaaa ggaagaagat gacgatgatg ggctggtgga 16320
gtttgtgcgc gagttcgccc caagacggcg cgtgcagtgg cgcgggcgca aagtgcgtca 16380
agtgctcaga cccgggacca ctgtggtttt tacacctggc gagcgttcca gcactacttt 16440
taaacggtcc tatgatgagg tgtacgggga tgacgatatt cttgagcagg cggcagaccg 16500
ccttgacgag tttgcttatg gcaagcgcac tagatccagt cccaaagagg aggctgtgtc 16560
cattcctttg gatcatggaa atcccacccc cagcctcaaa ccagtcaccc tgcagcaagt 16620
gctgcccgtg cctgcgcgga gaggcgtaaa gcgcgagggt gaggacctat atcccaccat 16680
gcagctaatg gtgcccaagc gccagaggct agaagacgta ctggagaaaa tgaaagtgga 16740
tgccgatatc cagcctgagg tcaaagtaag acctatcaag gaagtggcgc caggtttggg 16800
agtacaaacc ttcgacatca agattcccac cgagtccatg gaagtgcaga ccgaacctgc 16860
aaaacccacc acctcaattg aggtgcaaac ggaaccctgg atgcccgcgc ccgttgccgc 16920
ccccagcacc actcgaagat cacgacgaaa gtacggccca gcaagtctgc taatgcccaa 16980
ctatgctctg cacccatcca tcattcccac tccgggttac agaggcactc gctactatcg 17040
aaaccggagc aacacctctc gccgccgcaa accacctgca agtcgcactc gccgtcgccg 17100
ccgccgcaac actgccagca aattgactcc cgccgccctg gtgcggagag tgtaccgcga 17160
tggtcgcgct gaacctctga cgctgccgcg cgcgcgctac catccaagca tcaccactta 17220
atgactgttg acgctgcctc cttgcagata tggccctcac ttgccgcctt cgcgtcccca 17280
ttactggcta ccgaggaaga aactcgcgcc gtagaaggat gttggggcga gggatgcgcc 17340
gccacagacg aaggcgcgct atcagcagac gattaggggg tggctttttg ccagctctta 17400
tacccatcat cgccgcagcg atcggggcga taccaggcat agcttcagtg gcggttcagg 17460
cctcgcagcg ccactaacat tggaaaaaac ttataaataa aaaatagaat ggactctgac 17520
gctcctggtc ctgtgactat gtttttgtag agatggaaga catcaatttt tcatccctgg 17580
ctccgcgaca cggcacgagg ccgtacatgg gcacctggag cgacatcggc acgagccaac 17640
tgaacggggg cgccttcaat tggagcagta tctggagcgg gcttaaaaat tttggctcga 17700
ccgtaaaaac ctatgggaac aaagcttgga acagcagcac agggcaggct ctgagaaata 17760
agcttaagga acaaaacttc caacagaagg tggtcgatgg gatcgcctct ggtattaacg 17820
gcgtagtgga tctggccaac caggctgtac aaaaacagat aaacagccgc ctggacccgc 17880
cgcccgcaac ccctggtgaa atggaagtgg aggaagaact tcctccgctg gaaaagcggg 17940
gcgacaagcg tccgcgaccc gagctagagc agacgctggt gacgcgcgca gacgagcccc 18000
cttcatatga ggaggcagta aagctcggaa tgcccactac caggcctgta gctcacatgg 18060
ctaccggggt gatgaaacct tctcagtcac atcgacccgc caccttggac ttgcctcctc 18120
cccctgcttc tgcggcgcct gttcccaaac ctgtcgctac cagaaagccc accgccgtac 18180
agcccgtcgc cgtagccaga ccgcgtcctg ggggcacacc gcgcccgaaa gcaaactggc 18240
aaagtactct gaacagcatc gtgggtctgg gcgtgcagag tgtaaagcgc cgtcgctgct 18300
attaattaaa tatggagtag cgcttaactt gcttgtctgt gtgtatgtat catcaccacg 18360
ccgccgcagc agaggagaaa ggaagaggtc gcgcgccgag gctgagttgc tttcaagatg 18420
gccaccccat cgatgatgcc ccaatgggca tacatgcaca tcgccggaca ggatgcttcg 18480
gagtacctca gtccgggtct ggtgcagttc gcccgtgcaa cagacaccta cttcagtatg 18540
gggaacaaat ttagaaaccc cacagtggcg cccacccacg atgtgaccac cgaccgtagc 18600
cagcgcctga tgctgcgctt cgtgcccgtt gaccgggaag acaataccta ctcttacaaa 18660
gttcgctaca cgctggctgt aggcgacaac agagtgcttg acatggccag cacattcttt 18720
gacattcggg gggtgcttga tagaggtcct agcttcaagc catattccgg cacagcttac 18780
aattcactcg ctcctaaggg cgcgcccaat acatctcagt ggatagttac aacaaatggg 18840
gacaatgcag taactaccac cacaaacaca tttggcattg cttccatgaa gggagacaat 18900
attactaaag aaggtttgca aattgggaaa gacattacca ctactgaagg agaagaaaag 18960
cccatttatg ccgataaaac atatcagcca gagcctcaag ttggagaaga atcatggact 19020
gatactgatg gaacaaatga aaagtttggt ggaagagccc ttaaaccagc taccaacatg 19080
aagccatgct acgggtcttt tgcaagacct acaaacataa aagggggcca agctaaaaac 19140
agaaaagtaa aaccaacaac cgaaggaggg gttgaaactg aggaaccaga tattgatatg 19200
gaatttttcg atggtagaga tgctgttgca ggagctttag cgcctgaaat tgtgctttat 19260
acggaaaatg taaatttgga aactccagac agtcatgtgg tatataaacc agaaacgtct 19320
aataactctc atgcaaattt gggtcaacaa gccatgccta acagacccaa ttacattggc 19380
ttcagggata acttcgtagg cctaatgtac tacaacagta ctggaaatat gggagttttg 19440
gctggccaag catcacaact gaatgcagtg gttgacttgc aggacagaaa tactgaactg 19500
tcatatcagc ttttgcttga ttctctggga gacagaacca gatacttcag catgtggaat 19560
caggctgtgg acagttacga tcccgatgtt cgcattattg aaaatcatgg catcgaggat 19620
gaactgccta attactgttt tcctctgaat ggcataggac cagggcacac atatcaaggc 19680
attaaagtta aaaccgatga cactaatgga tgggaaaaag atgctaatgt tgctccagct 19740
aatgaaataa ccataggcaa caacctggct atggaaatta atatccaagc taacctttgg 19800
agaagttttc tgtactctaa tgtggctttg taccttccag atgtttacaa gtacacgcca 19860
cctaacatta ctttgcccac taacaccaac acctatgagt acatgaacgg gcgagtggta 19920
tccccatccc tggttgattc atacatcaac attggcgcca ggtggtctct tgacccaatg 19980
gacaatgtga atccattcaa ccaccaccgc aatgctggtc tgcgctacag gtccatgctt 20040
ctgggaaatg gtcgttatgt gcctttccac atacaagtgc ctcagaaatt ctttgctgtc 20100
aagaacctac ttcttctacc tggctcctac acctacgagt ggaacttccg aaaggatgtg 20160
aacatggtcc tgcaaagttc ccttggaaat gacctcagaa cggatggtgc taccataagt 20220
ttcaccagca tcaatctcta tgccaccttc ttccccatgg ctcacaacac agcttccacc 20280
cttgaagcca tgctgcgcaa cgataccaat gatcagtcat ttaacgacta cctctctgca 20340
gctaacatgc tttaccccat tcctgccaat gcaaccaaca ttccaatttc catcccatct 20400
cgcaactggg cagccttcag gggctggtcc ttcaccagac tcaaaaccaa ggagactcca 20460
tctcttggat cagggttcga tccctacttc gtatattctg gatctattcc ctacctggat 20520
ggcacctttt accttaacca cactttcaag aaggtctcca tcatgtttga ctcctcagtc 20580
agctggcctg gcaatgacag gctgttgagt ccaaatgagt ttgaaatcaa gcgcactgtg 20640
gacggggaag gatacaacgt ggcacaatgc aacatgacca aagactggtt cctggttcag 20700
atgcttgcca attacaacat tggctaccag ggcttttaca tccctgaggg atacaaggat 20760
cgcatgtact cctttttcag aaacttccag cctatgagca ggcaggtggt tgatgaggtt 20820
aattacactg actacaaagc cgtcacctta ccataccaac acaacaactc tggctttgta 20880
gggtaccttg cacctactat gagacaaggg gaaccttacc cagccaatta tccatacccg 20940
ctcatcggaa ctactgccgt taagagtgtc acccagaaaa agttcctgtg cgacaggacc 21000
atgtggcgca ttcccttctc cagcaacttc atgtccatgg gggcccttac cgacctggga 21060
cagaacatgc tctatgccaa ctcagcccat gcgctggaca tgacttttga ggtggatccc 21120
atggatgagc ccaccctgct ttatcttctt ttcgaagtct tcgacgtggt cagagtgcac 21180
cagccacacc gcggcgtcat cgaggccgtc tacctgcgca caccgttctc ggccggcaac 21240
gccaccacat aagaagcctc ttgcttcttg caagcagcag ctgcagccat gacatgcggg 21300
tccggaaacg gctccagcga gcaagagctc aaagccatcg tccgagacct gggctgcgga 21360
ccctatttcc tgggaacctt tgacaagcgt ttcccggggt tcatggcccc cgacaagctc 21420
gcctgcgcca tagtcaacac tgccggacgc gagacggggg gagagcactg gctggctttt 21480
ggttggaacc cgcgctacaa cacctgctac ctttttgatc cttttgggtt ctcggatgag 21540
cggctcaaac agatttacca gtttgagtac gaggggctcc tgcgtcgcag tgcccttgct 21600
accaaagacc gctgcatcac cctggagaag tctacccaaa gcgtgcaggg tccgcgctca 21660
gccgcctgtg gacttttttg ctgtatgttc cttcatgcct ttgtgcactg gcccgaccgc 21720
cccatggacg gaaaccccac catgaagttg ctgactgggg tgtccaacag catgctccaa 21780
tcaccccaag tccagcccac cctgcgccgc aaccaggagg tgctataccg cttcctaaac 21840
acccactcat cttactttcg ttctcaccgc gcgcgcattg aaagggccac cgcgtttgac 21900
cgtatggata tgcaataagt catgtaaaac cgtgttcaat aaacagcact ttatttttac 21960
atgcactgag gctctggttt tgctcatttg tttcatcatt tactcagaag tcgaatgggt 22020
tctggcggga gtcagagtga cccgcgggca gggatacgtt gcggaactgt aacctgttct 22080
gccacttgaa ctcggggatt accagcttgg gaactggaat ctcgggaaag gtgtcttgcc 22140
acaactttct ggtcagttgc atagcgccaa gcaggtcagg agcagagatc ttgaaatcac 22200
agttggggcc ggcattctgg acacgggagt tgcgatacac tgggttgcaa cactggaaca 22260
ctatcaacgc tgggtgtctt acgcttgcca acacggttgg gtcactgatg gtagtcacat 22320
ccaagtcttc agcattggcc atcccaaagg gggtcatctt acatgtctgc ctgcccatca 22380
cgggagcgca gcctggcttg tggttgcaat cacaatgaat ggggatcagc atcatcctgg 22440
cttggtcggg agttatccct gggtacacag ccttcatgaa ggcttcgtac tgcttaaaag 22500
cttcctgggc cttacttccc tcggtgtaga acatcccaca ggacttgctg gaaaattgat 22560
tagtagtaca gttggcatca ttcacacaac agcgggcatc gttgttggcc aactgaacca 22620
catttctgcc ccagcggttt tgggtgatct tggctctgtc tggattctcc ttcatagcgc 22680
gctgcccgtt ctcgctcgcc acatccatct cgataatgtg gtccttctgg atcatgatag 22740
tgccatgcag gcatttcacc ttgccttcat aatcggtgca tccatgagcc cacagagcgc 22800
acccggtgca ctcccaatta ttgtgggcga tctcagaata ataatgtacc aatccctgca 22860
tgaatcttcc catcattgtt gtcaaggtct tcatgctggt aaatgtcagc gggatgccac 22920
ggtgctcctc gttcacatac tggtggcaga tacgcttgta ttgctcgtgc tgctctggca 22980
tcagcttgaa agaggttctc agatcattat ccagcctgta cctttccatt agcacagcca 23040
tcacttccat gcccttctcc caggcagata ccaggggcag actcaaagga ttcctaacag 23100
caataaaagt agctccttta gctatagggt cattcttgtc gatcttctca acacttctct 23160
tgccatcctt ctcaatgatg cgcaccgggg ggtagctgaa gcccacggcc accaactgag 23220
cctgttctct ttcttcttca ctatcctggc tgatgtcttg cagagggaca tgcttggtct 23280
tcctgggctt cttcttggga gggatcgggg gaggactgtt gctccgctcc ggagacaggg 23340
atgactgcga agtttcgctt accaatacca cctggctctc ggtagaagaa ccggacccca 23400
cacgacggta ggtgttcctc ttcgggggca gaggtggagg cgactgagat gggctgcggt 23460
ctggccttgg aggcggatgg ctggcagagc tcattccgcg ttcgggggtg tgctcccggt 23520
ggcggtcgct tgactgattt cctccgcggc tggccattgt gttctcctag gcagagaaac 23580
aacagacatg gaaactcagc catcactgcc aacatcgctg caagcaccat cacacctcgc 23640
ccccagcagc gacgaggagg agagcttaac caccccacca cccagtcccg ctaccaccac 23700
ctctaccctc gatgatgagg aggaggtcga cgcagcccag gagatgcagg cgcaggataa 23760
tgtgaaaacg gaagagattg aggcagatgt cgagcaggac ccgggctatg tgacgccggc 23820
ggagcaccag gaggagctga aacgctttct agacagagag gatgacgacc gcccagagca 23880
tcaagcagat ggcgtttacc aggaggctgg gatcagggat catgtcgccg actacctcac 23940
cggccttggt ggggaggacg tgctcctcaa acatctagca aggcagtcga tcatagttaa 24000
agacgcattg ctcgatctca ctgaagtgcc catcagtgtg gaagagctta gccgcgccta 24060
cgagctgaac ctcttttcgc ctcaggtacc ccccaagcgg cagccaaacg gcacctgcga 24120
ggccaaccct cgactcaact tctatccagc ttttactatc cccgaagtgt tggccaccta 24180
ccacatcttt ttcaagaacc aaaagattcc agtctcctgc cgcgccaacc gcacccgcgc 24240
cgatgccctg ctcaacttgg gtccgggagc tcgcttacct gatatagctt ccttggaaga 24300
ggttccaaag atctttgagg gtctgggaag tgatgagaca cgggccgcaa atgctctgca 24360
acagggagag aatgacatgg atgaacacca cagcgctctg gtggaactgg agggtgacaa 24420
tgcccggatt gcagtgctca agcgcagtat cgtggtcacc cattttgcct accccgctgt 24480
taacctgccc cccaaagtta tgagcgctgt catggaccat ctgctcatca aacgagcaag 24540
acctctttca gaaaaccaga acatgcagga tccagacgcc tcggacgagg gcaagccggt 24600
agtcagtgac gagcagctat ctcgctggct gggtaccaac tccccccgag atttggaaga 24660
gaggcgcaag cttatgatgg ctgtagtgct agtaactgtg gagctggagt gtctgcgccg 24720
ctttttcacc gaccctgaga ccctgcgcaa gctagaggag aacctgcact acacctttag 24780
acatggcttc gtgcggcagg catgcaagat ctccaacgtg gagcttacca acctggtttc 24840
ttacatgggc attttgcatg agaaccgact agggcagagc gtcctgcaca ccacccttaa 24900
aggggaggcc cgccgtgact acatccgaga ctgtgtctac ctctacctct gccatacctg 24960
gcaaactggt atgggtgtgt ggcaacagtg tttggaagag cagaacctaa aagagctgga 25020
caagctcttg cagagatccc tcaaagccct gtggacaggt tttgatgagc gcaccgtcgc 25080
ctcggacctg gcagacatca tcttccccga gcgtctcagg gttactctgc gaaacggcct 25140
gccagacttt atgagccaga gcatgcttaa caactttcgc tctttcatcc tggaacgctc 25200
cggtatcctg cctgccacct gctgtgcgct gccctccgac tttgtgcctc tcacctaccg 25260
cgagtgccca ccgccgctat ggagccactg ctacctgttc cgcctggcca actacctctc 25320
ctaccactcg gatgttatag aggatgtgag cggagacggc ctgctggaat gccactgccg 25380
ctgcaatctt tgcacacccc accgctccct tgcctgcaac ccccagttgc tgagcgagac 25440
ccagattatc ggcaccttcg agctgcaggg tcccagaagt aaaggcgagg ggtcttctcc 25500
ggggcagagt ttgaaactga caccggggct gtggacctcc gcctacctgc gcaagtttca 25560
ccccgaggac taccatccct atgagatcag gttctatgag gaccaatcac atcctcccaa 25620
agtcgagctc tcagcctgcg tcatcaccca gggagcaatt ctggcccaat tgcaagccat 25680
ccaaaaatct cgccaagaat ttctgctaaa aaagggaaac ggggtctacc ttgaccctca 25740
gaccggtgag gagctcaaca caaggttccc ccaggatgtc ccatcgccga ggaagcaaga 25800
agttgaaggt gcagctgtcg cccccagagg atatgaagga agactgggac agtcaggcag 25860
aggaggagat ggaagattgg gacagccagg cagaggaggt ggacagcctg gaggaagaca 25920
gtttggagga ggaagacgag gaggcagagg aggtggaaga agcaaccgcc gccaaacagt 25980
tgtcatcggc ggcggagaca agcaagtccc cagacagcag cacggctacc atctccgctc 26040
cgggtcgggg ggcccagcgg cggcccaaca gtagatggga cgagaccggg cgattcccaa 26100
acccgaccac cgcttccaag accggtaaga aggagcgaca gggatacaag tcctggcgtg 26160
gacataaaaa cgctatcatc tcctgcttgc atgaatgcgg gggcaacata tccttcaccc 26220
ggcgatacct gctcttccac cacggtgtaa acttcccccg caatatcttg cattactacc 26280
gtcacctcca cagcccctac tgcagtcagc aagtcccggc aaccccgaca gaaaaataca 26340
gcagcgacaa cggtgaccag aaaaccagca gttagaaaat ccacaacaag tgcaccagga 26400
ggaggactga ggatcacagc gaacgagcca gcgcagacca gagagctgag gaaccggatc 26460
tttccaaccc tctatgccat tttccagcag agtcgggggc aagagcagga actgaaagta 26520
aaaaaccgat ctctgcgctc gctcaccaga agttgtttgt atcacaagag cgaagaccaa 26580
cttcagcgca ctctcgagga cgccgaggct ctcttcaaca agtactgcgc gctgactctt 26640
aaagagtagc ccttgcccgc gctcattttg aaaacggcgg gaatcacgtc acccttggca 26700
cctgtccttt gcccttgtca tgagtaaaga gattcccacg ccttacatgt ggagctatca 26760
gccccaaatg gggttggcag caggcgcttc ccaggactac tccacccgca tgaattggct 26820
tagcgccggg ccctcaatga tatcacgggt taatgatata cgagcttatc gaaaccagtt 26880
actcctagaa cagtcagctc tcaccaccac accccgtcaa caccttaatc cccgaaattg 26940
gcccgccacc ctggtgtacc aggaaaatcc cgctcccacc accgtactac ttcctcgaga 27000
cgcccaggcc gaagttcaga tgactaacgc aggtgtacag ctggcgggcg gttccgccct 27060
atgtcgtcac cgacctcaac agagtataaa acgcctggtg attagaggcc gaggtatcca 27120
gctcaacgac gagtcggtta gctcttcgct tggtctgcga ccagacggag tcttccaaat 27180
cgccggctgt gggagatctt ccttcactcc tcgtcaggct gtgctgactt tggagagttc 27240
gtcctcgcag ccccgctcgg gcggcattgg aactctccag tttgtggagg agtttactcc 27300
ctctgtctac ttcaacccct tctccggctc tcctggccag tacccggacg agttcatacc 27360
aaacttcgac gcaatcagcg agtcagtgga tggctatgat tgatgtctaa tggtggtgcg 27420
gctgagctag ctcgactgcg acacctagac cactgccgcc gctttcgctg cttcgcccgg 27480
gaactcaccg agttcatcta cttcgaactc tccgaggagc accctcaggg tccggcccac 27540
ggagtgcgga ttaccatcga agggggaata gactctcgcc tgcatcgcat cttctcccag 27600
cggcccgtgc taattgaacg cgaccaggga aatacaacca tctccatcta ctgcatctgt 27660
aaccaccccg gattgcatga aagcctttgc tgtcttgttt gtgctgagtt taataaaaac 27720
tgagttaaga ccctcctacg gactaccgct tcttcaatca ggactttaca acaccaacca 27780
gatcttccag aagacccaga cccttcctcc tttcatccag gactctaact ctaccttacc 27840
agcaccctcc actactaacc ttcccgaaac aaacaagctt gcatctcatc tgcaacaccg 27900
cctttcacga agccttcttt ctgccaatac taccactccc aaaaccggag gtgagctccg 27960
cggtcttcct actgacgacc cctgggtggt agcgggtttt gtaacgttag gagtagttgc 28020
gggtgggctt gtgctgatcc tttgctacct atacacacct tgctgtgcat atttagtcat 28080
attgtgctgt tggtttaaga aatgggggcc atactagtcg tgcttgcttt actttcgctt 28140
ttgggtctgg gctctgctaa tctcaatcct ctcgatcacg atccatgttt agacttcgac 28200
ccagaaaact gcacacttac ttttgcaccc gacacaagcc gtctctgtgg agttcttatt 28260
aagtgcggat gggactgcag gtccgttgaa attacacata ataacaaaac atggaacaat 28320
accttatcca ccacatggga gccaggagtt ccccagtggt atactgtctc tgtccgaggt 28380
cctgacggtt ccatccgcat tagtaacaac actttcattt tttctgaaat gtgcgatctg 28440
gccatgttca tgagcagaca gtatgaccta tggcctccca gcaaagagaa cattgtggca 28500
ttttccattg cttattgctt ggtaacatgc atcatcactg ctatcatttg tgtgtgcata 28560
cacttgctta tagttattcg ccctagacaa agcaatgagg aaaaagagaa aatgccttaa 28620
cctttttcct catacctttt ctttacagca tggcttctgt tacagctcta attattgcca 28680
gcattgtcac tgtcgctcac gggcaaacaa ttgtccatat taccttagga cataatcaca 28740
ctcttgtagg gcccccaatt acttcagagg ttatttggac caaacttgga agtgttgatt 28800
attttgatat aatttgcaac aaaactaaac caatatttgt aatctgtaac agacaaaatc 28860
tcacgttaat taatgttagc aaaatttata acggttacta ttatggttat gacagatcca 28920
gtagtcaata taaaaattac ttagttcgca taactcagcc caaattaaca gtgccaacta 28980
tgacaataat taaaatggct aataaagcat tagaaaattt tacatcacca acaacaccca 29040
atgaaaaaaa cattccaaat tcaatgattg caattattgc ggcggtggca ttgggaatgg 29100
cactaataat aatatgcatg ctcctatatg cttgttacta taaaaagttt caacataaac 29160
aggatccact actaaatttt aacatttaat tttttataca gatgatttcc actacaattt 29220
ttatcattac tagccttgca gctgtaactt atggccgttc acacctaact gtacctgttg 29280
gctcaacatg tacactacaa ggaccccaag aaggctatgt cacttggtgg agaatatatg 29340
ataatggagg gttcgctaga ccatgtgatc agcctggtac aaaattttca tgcaacggaa 29400
gagacttgac cattattaac ataacatcaa atgagcaagg cttctattat ggaaccaact 29460
ataaaaatag tttagattac aacattattg tagtgccagc caccacttct gctccccgca 29520
aatccacttt ctctagcagc agtgccaaag caagcacaat tcctaaaaca gcttctgcta 29580
tgttaaagct tccaaaaatc gctttaagta attccacagc cgctcccaat acaattccta 29640
aatcaacaat tggcatcatt actgccgtgg tagtgggatt aatgattata tttttgtgta 29700
taatgtacta cgcctgctgc tatagaaaac atgaacaaaa aggtgatgca ttactaaatt 29760
ttgatattta attttttata gaattatgat attgtttcaa tcaaatacca ctacctccta 29820
tgcatacaca aacattcagc ctaaatacgc tatgcaacta gaaatcacaa tactaattgt 29880
aattggaatt cttatactat ctgttattct ttattttata ttctgccgtc aaatacccaa 29940
tgttcataga aattctaaaa gacgtcccat ctattctcct atgattagtc gtccccatat 30000
ggctctgaat gaaatctaag atcttttttt ttttctctta cagtatggtg aacatcaatc 30060
atgatcccta gaaatttctt cttcaccata ctcatctgtg cttttaatgt ctgtgctact 30120
ttcacagcag tagccactgc aagcccagac tgtataggac catttgcttc ctatgcactt 30180
tttgccttcg ttacttgcat ctgcgtgtgt agcatagtct gcctggttat taattttttc 30240
caactggtag actggatctt tgtgcgaatt gcctacctac gtcaccatcc cgaataccgc 30300
aatcaaaatg ttgcggcact tcttaggctt atttaaaacc atgcaggcta tgctaccagt 30360
cattttaatt ttgctactac cctgcattcc cctagcttcc accgccactc gcgctacacc 30420
tgaacaactt agaaaatgca aatttcaaca accatggtca tttcttgatt gctaccatga 30480
aaaatctgat tttcccacat actggatagt gattgttgga ataattaaca tactttcatg 30540
tacctttttc tcaatcacaa tataccccac atttaatttt gggtggaatt ctcccaatgc 30600
actgggttac ccacaagaac cagatgaaca tattccacta caacacatac aacaaccact 30660
agcactggta cagtatgaaa atgagccaca accttcactg ccccctgcca ttagttactt 30720
caacctaacc ggcggagatg actgacccaa tcgccacatc atccaccgct gccaaggagc 30780
tgctggacat ggacggacgt gcctcagaac agcgactcat ccaactacgc attcgtcagc 30840
agcaggaacg agcagtaaaa gagctaaggg atgccattgg gattcaccag tgcaaaaaag 30900
gcatattctg cttagtaaaa caatccaaaa tctcctacga gatcaccgct actgaccatc 30960
gtctctcata cgagctcggt ccgcagcgac aaaaattcac ctgcatggtg ggaatcaacc 31020
ccatagttat cacccagcag tctggagata ctaagggttg tatccagtgt tcctgtgatt 31080
ccaccgagtg catctacaca ctgctgaaga ccctctgcgg ccttcgagac ctcctaccca 31140
tgaactaatc attgccccta ccttacccaa tcaaaatatt aataaagaca cttacttgaa 31200
atcagcaata cagtctttgt caaaactttc taccagcagc acctcaccct cttcccaact 31260
ctggtactct aaacgtcgga gggtggcata ctttctccac actttgaaag ggatgtcaaa 31320
ttttatttcc tcttctttgc ccacaatctt catttcttta tccccagatg gccaagcgag 31380
ctcggctaag cacttccttc aacccggtgt acccttatga agatgaaagc agctcacaac 31440
acccatttat aaatcctggt ttcatttccc ctgacgggtt cacacaaagt ccaaacgggg 31500
ttttaagtct taaatgtgtt aatccactta ccactgcaag cggctccctc caacttaaag 31560
tgggaagtgg tcttacagta gacactactg atggatcctt agaagaaaac atcaaagtta 31620
acacccccct aacaaagtca aaccattcta taaatttacc aataggaaac ggtttgcaaa 31680
tagaacaaaa caaactttgc agtaaactcg gaaatggtct tacatttgac tcttccaatt 31740
ctattgcact gaaaaataac actttatgga caggtccaaa accagaagcc aactgcataa 31800
ttgaatacgg gaaacaaaac ccagatagca aactaacttt aatccttgta aaaaatggag 31860
gaattgttaa tggatatgta acgctaatgg gagcctcaga ctacgttaac accttattta 31920
aaaacaaaaa tgtctccatt aatgtagaac tatactttga tgccactggt catatattac 31980
cagactcatc ttctcttaaa acagatctag aactaaaata caagcaaacc gctgacttta 32040
gtgcaagagg ttttatgcca agtactacag cgtatccatt tgtccttcct aatgcgggaa 32100
cacataatga aaattatatt tttggtcaat gctactacaa agcaagcgat ggtgcccttt 32160
ttccgttgga agttactgtt atgcttaata aacgcctgcc agatagtcgc acatcctatg 32220
ttatgacttt tttatggtcc ttgaatgctg gtctagctcc agaaactact caggcaaccc 32280
tcataacctc cccatttacc ttttcctata ttagagaaga tgactgacaa caaaaataaa 32340
gttcaacatt ttttattgaa attcctttta cagtattcga gtagttattt tgcctccccc 32400
ttcccattta acagaataca ccaatctctc cccacgcaca gctttaaaca tttggatacc 32460
attagagata gacatagttt tagattccac attccaaaca gtttcagagc gagccaatct 32520
ggggtcagta atacataaaa atgcatcggg atagtctttt aaagcgcttt cacagtccaa 32580
ctgttgcgga tgcgactccg gagtctgaat cacggtcatc tggaagaaga acgatgggaa 32640
tcataatccg aaaacggaat cgggcgattg tgtctcatca aacccacaag caaccgctgt 32700
ctgcgtcgct ccgtgcgact gctgtttatg ggatcggggt ccgcagtgtc ctgaagcatg 32760
attttaatag cccttaacat taactttctg gtgcgatgcg cgcagcaacg cattctgatt 32820
tcacttagat tactacagta ggtacagcac attatcacaa tattgtttaa taaaccataa 32880
ttaaaagcgc tccagccaaa actcatatct gatataatcg cccctgcatg accatcatac 32940
caaagtttaa tataaattaa atgtcgttcc ctcaaaaaca cactacccac atacatgatc 33000
tcttttggca tgtgcatatt aacaatttgt ctgtaccatg gacaacgttg gttaatcatg 33060
caacccaata taaccttccg gaaccacact gccaacaccg ctcccccagc catgcattga 33120
agtgaaccct gctgattaca atgacaatga agaacccaat tctctcgacc atgaatcact 33180
tgagactgaa aaatatctat agtagcacaa caaagacata aatgcatgca tcttctcata 33240
atttttaact cctctggatt taaaaacata tcccaaggaa tgggaaactc ttgcagaaca 33300
gtaaagctgg cagaacaagg aagaccacga acacaactta cactatgcat agtcatagta 33360
tcacaatctg gcaacagcgg gtggtcttca gtcatagaag ctcgggtttc attttcctca 33420
catcgtggta attgggctct ggtgtaaggg tgatgtctgg cgcatgatgt ggagcgtgcg 33480
cgcaaccttg tcataatgga gttgcttcct gacattctcg tattttgtat agcaaaacgc 33540
tgccctggca caacacactc ttcttcgtct tctatcctgc cgcttagtgt gttccgtctg 33600
ataattcaag tacagccaca ctcttaagtt ggtcaaaaga atgctggctt cagttgtaat 33660
caaaactcca tcatatttaa ttgttctaag gaaatcatcc acggtagcat atgcaaatcc 33720
caaccaagca atgcaactgg attgcgtttc aagcagcaga ggagagggaa gagacggaag 33780
aatcatgtta atttttattc caaacgatct cgcagtactt caaattgtag atcgcgcaga 33840
tggcatctat cgcccccact gtgttggtga aaaagcacag ctaaatcaaa agaaatgcga 33900
ttttcaaggt gctcaacggt ggcttccaac aaagcctcca cgcgcacatc caaaaacaaa 33960
agaataccaa aagaaggagc attttctaac tcctcaaaca tcatattaca ttcctgcacc 34020
attcccagat aattttcagc tttccagcct tgaattattc gtgtcagttc ttgtggtaaa 34080
tccaaaccac acattacaaa caggtcccgg agggcgccct ccaccaccat tcttaaacac 34140
accctcataa tgacaaaata tcttgctcct gtgtcacctg tagcaaatta agaatggcat 34200
catcaattga catgcccttg gctctaagtt cttctctaag ttctagttgt agatactctc 34260
tcatattatc accaaactgc ttagccagaa gccccccggg aacaatagca ggggacgcta 34320
cagtgcagta caagcgcaga cctccccaat tggctccagc aaaaacaaga ttagaataag 34380
catactggga accaccagta atatcatcaa agttgctgga aatataatca ggcagagttt 34440
cttgtaaaaa ttgaataaaa gaaaaatttt ccaaagaaac attcaaaacc gttgggatgc 34500
aaatacaata ggttaccgcg ctgcgctcca acattgttag ttttgaatta gtctgcaaaa 34560
taaaagaaac aagcgtcata tcatagtagc ctgtcgaaca ggtggaaaaa tcagtctttc 34620
catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt cattgtgatt 34680
aaacaacagc accgaaagtt cctcgcggtg gccagcatga ataattcttg atgaagcata 34740
caatccagac atgttagcat cagttaaaga gaaaaaacag ccaacatagc ctctgggtat 34800
aattatgctt aattttaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34860
aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgttg ctcccggtcc 34920
ctctaaatag acatacaaag cctcatcagc catggcttac caggcaaagt acagcgggcg 34980
cacaaagcac aagctctaaa gaagctctaa aaacactctc caacctctcc acaatatata 35040
cacaagccct aaactgacgt aatgggagta aagtgaaaaa aaaataccgc caagcccaac 35100
acacaccccg aaactgcgtc agcaggaaaa agtacagttt cacttccgca ttcccaacaa 35160
gcgtaacttc ctctttctca tggtacgtca catccgatta acttgcaacg tcattttccc 35220
acggtcgcgc cgcccctttt agccgttaac cccgcagcca atcaccacac agcgcgcact 35280
tttttaaatt acctcattta catgttggca ccattccatc tataaggtat attatataga 35340
tag 35343
<210> 140
<211> 35083
<212> DNA
<213> 人9型腺病毒（Human adenovirus type 9）
<400> 140
ctatctatat aatatacccc acaaagtaaa caaaagttaa tatgcaaatg agcttttgaa 60
ttttaacggt ttcggggcgg agccaacgct gattggacga gagaagacga tgcaaatgac 120
gtcacgacgc acggctaacg gtcgccgcgg aggcgtggcc tagcccggaa gcaagtcgcg 180
gggctgatga cgtataaaaa agcggacttt agacccggaa acggccgatt ttcccgcggc 240
cacgcccgga tatgaggtaa ttctgggcgg atgcaagtga aattaggtca ttttggcgcg 300
aaaactgaat gaggaagtga aaagcgaaaa ataccggtcc ctcccagggc ggaatattta 360
ccgagggccg agagactttg accgattacg tgggggtttc gattgcggtg tttttttcgc 420
gaatttccgc gtccgtgtca aagtccggtg tttatgtcac agatcagctg atccgcaggg 480
tatttaaacc agtcgagtcc gtcaagaggc cactcttgag tgccagcgag tagagatttc 540
tctgagctcc gctcccagag accgagaaaa atgagacacc tgcgcctcct gccttcaact 600
gtgcccggtg agctggctgt gcttatgctg gaggactttg tggatacagt attggaggac 660
gaactgcatc caagtccgtt cgagctggga cccacacttc aggatctcta tgatctggag 720
gtagatgccc atgatgacga ccctaacgag gaggctgtga atttaatatt tccagaatct 780
atgattcttc aggctgacat agccaacgaa tctactccac ttcatacacc gactctgtca 840
cccatacctg aattggaaga ggaggacgaa ctagacctcc ggtgttatga ggaaggtttt 900
cctcccagcg attcagagga tgaacggggt gagcagacca tggctctgat ctcagactat 960
gcttgtgtga ttgtggagga gcaagatgtg attgaaaaat ctactgagcc agtacaaggc 1020
tgtaggaact gccagtacca ccgggataag tccggagatg tgaacgcctc ctgcgctttg 1080
tgctatatga aacagacttt cagctttatt tacagtaagt ggagtgaatg tgagagaggc 1140
tgagtgctta acacataact gtaatgcttg aacagctgtg ctaagtgtgg tttattttgt 1200
tactaggtcc ggtgtcagag gatgagttat caccctcaga agaagaccac ccgtctcccc 1260
ctgagctgtc aggcgaaacg cccctgcaag tgttcagacc caccccagtc agacccagtg 1320
gcgagaggcg agcggctgtt gacaaaattg aggacttgtt gcaggacatg ggtggggatg 1380
aacctttgga cctgagcttg aaacgcccca ggaactagac gcagctgcgc ttagtcatgt 1440
gtaaataaag ttgtacaata aaagtctatg tgacgcatgc aaggtgtggt ttatgactca 1500
tgggcggggc ttagtcctat ataagtggca acacctgggc acttgggcac agaccttcag 1560
ggagttcctg atggatgtgt ggactatcct tgcagacttt agcaagacac gccggcttgt 1620
agaggatagt tcagacgggt gctccgggtt ctggagacac tggtttggaa ctcctctatc 1680
tcgcctggtg tacacagtta agaaggatta taaagaggaa tttgaaaata tttttgctga 1740
ctgctctggc ctgctagatt ctctgaatct tggccaccag tcccttttcc aggaaagggt 1800
actccacagc cttgattttt ccagcccagg gcgcactaca gccggggttg cttttgtggt 1860
ttttctggtt gacaaatgga gccaggacac ccaactgagc aggggctaca tcctggactt 1920
cgcagccatg cacctgtgga gggcctggat caggcagcgg ggacagagaa tcttgaatta 1980
ctggcttcta cagccagcag ctccgggtct tcttcgtcta cacagacaaa catccatgtt 2040
ggaggaagaa atgaggcagg ccatggacga gaacccgagg agcggcctgg accctccgtc 2100
ggaagaggag ctggattgaa tcaggtatcc agcctgtacc cagagcttag caaggtgctg 2160
acatccatgg ccaggggagt taagagggag aggagcgatg ggggtaatac cgggatgatg 2220
accgagctga cggccagcct gatgaatcgg aagcgcccag agcgccttac ctggtacgag 2280
ctacagcagg agtgcaggga tgagttgggc ctgatgcagg ataaatatgg cctggagcag 2340
ataaaaaccc attggttgaa cccagatgag gattgggagg aggctattaa gaagtatgcc 2400
aagatagccc tgcgcccaga ttgcaagtac atagtgacca agaccgtgaa tatcagacat 2460
gcctgctaca tctcggggaa cggggcagag gtggtcatcg ataccctgga caaggccgcc 2520
ttcaggtgtt gcatgatggg aatgagagca ggagtgatga atatgaattc catgatcttc 2580
atgaacatga agttcaatgg agagaagttt aatggggtgc tgttcatggc caacagccac 2640
atgaccctgc atggctgcag tttcttcggc ttcaacaata tgtgcgcaga ggtctggggc 2700
gcttccaaga tcaggggatg taagttttat ggctgctgga tgggcgtggt cggaagaccc 2760
aagagcgaga tgtctgtgaa gcagtgtgtg tttgagaaat gctacctggg agtctctacc 2820
gagggcaatg ctagagtgag acactgctct tccctggaga cgggctgctt ctgcctggtg 2880
aagggcacag cctctctgaa gcataatatg gtgaagggct gcacggatga gcgcatgtac 2940
aacatgctga cctgcgattc gggggtctgc catatcctga agaacatcca tgtgacctcc 3000
caccccagaa agaagtggcc agtgtttgag aataacctgc tgatcaagtg ccatatgcac 3060
ctgggagcca gaaggggcac cttccagccg taccagtgca actttagcca gaccaagctg 3120
ctgttggaga acgatgcctt ctccagggtg aacctgaacg gcatctttga catggatgtc 3180
tcggtgtaca agatcctgag atacgatgag accaagtcca gggtgcgcgc ttgcgagtgc 3240
gggggcagac acaccaggat gcagccagtg gccctggatg tgaccgagga gctgagacca 3300
gaccacctgg tgatggcctg taccgggacc gagttcagct ccagtgggga ggacacagat 3360
tagaggtagg tcgagtgagt agtgggcgtg gctaaggtga ctataaaggc gggtgtctta 3420
cgagggtctt tttgcttttc tgcagacatc atgaacggga ccggcggggc cttcgaaggg 3480
gggcttttta gcccttattt gacaacccgc ctgccgggat gggccggagt tcgtcagaat 3540
gtgatgggat cgacggtgga tgggcgccca gtgcttccag caaattcctc gaccatgacc 3600
tacgcgaccg tggggagctc gtcgctcgac agcaccgccg cagccgcggc agccgcagct 3660
gccatgacag cgacgagact ggcctcgagc tacatgccca gcagcggcag cagcccctct 3720
gtgcccagtt ccatcatcgc cgaggagaaa ctgctggccc tgctggccga gctggaagcc 3780
ctgagccgcc agctggccgc cctgacccag caggtgtccg agctccgcga gcagcaacag 3840
cagcaaaata aatgattcaa taaacacaga ttctgattca aacagcaaag catctttatt 3900
atttattttt tcgcgcgcgg taggccctgg tccacctctc ccgatcattg agagtgcggt 3960
ggattttttc caggacccgg tagaggtggg attggatgtt gaggtacatg ggcatgagcc 4020
cgtcccgggg gtggaggtag caccactgca tggcctcgtg ctctggggtc gtgttgtaga 4080
tgatccagtc atagcagggg cgctgggcgt ggtgctggat gatgtctttg agaaggagac 4140
tgatggccac ggggagcccc ttggtgtagg tattggcgaa gcggttgagc tgggagggat 4200
gcatgcgggg ggagatgatg tgcagtttgg cctggatctt gaggttggcg atgttgccac 4260
ccagatcccg ccgggggttc atgttgtgca ggaccaccag gacggtgtag cccgtgcact 4320
tggggaactt gtcatgcaac ttggaaggga atgcgtggaa gaatttggag acgcccttgt 4380
gcccgcccag gttttccatg cattcatcca tgatgatggc gatgggcccg tgggctgcgg 4440
ctttggcaaa gacgtttctg gggtcagata catcataatt atgctcctgg gtgagatcat 4500
cataagacat tttaatgaat ttggggcgga gggtgccaga ttgggggacg atggttccct 4560
cgggccccgg ggcgaagttc ccctcacaga tctgcatctc ccaggctttc atctcggagg 4620
gggggatcat gtccacctgc ggggcgatga aaaaaacggt ttccggggct ggggtgatga 4680
gctgcgaaga gagcaggttt ctcaacagct gggacttgcc gcacccggtc gggccgtaga 4740
tgaccccgat gacgggttgc aggtggtagt tcaaggacat gcagctgccg tcgtcccgga 4800
ggaggggggc cacctcgttg agcatgtctc tgacttggag gttttcccga acgagctcgc 4860
cgaggaggcg gtccccgccc agcgagagga gctcttgcag ggaagcaaag tttttcaggg 4920
gcttgagtcc gtcggccatg ggcatcttgg cgagggtctg cgagaggagc tccaggcggt 4980
cccagagctc ggtgacgtgc tctacggcat ctcgatccag cagacttcct cgtttcgggg 5040
gttgggacga ctgcgactgt agggcacgag acgatgggcg tccagcgcgg ccagcgtcat 5100
gtccttccag ggtctcaggg tccgagtgag ggtggtctcc gtcacggtga aggggtgggc 5160
ccctggctgg gcgcttgcaa gggtgcgctt gagactcatc ctgctggtgc tgaaacgggc 5220
acggtcttcg ccctgcgagt cggcgagata gcagttgacc atgagctcgt agttgagggc 5280
ctcggcggcg tggcccttgg cgcggagctt gcccttggaa gagcgcccgc aggcgggaca 5340
gaggagggat tgcagggcgt agagcttggg ggcgagaaag acggactcgg gagcgaaagc 5400
gtccgctccg cagtgggcgc agacggtctc gcactcgacg agccaggtga gctctggctg 5460
ctcggggtca aaaaccagtt ttcccccgtt ctttttgatg cgcttcttac ctcgcgtctc 5520
catgagtctg tgtccgcgct cggtgacaaa caggctgtcg gtgtccccgt agacggactt 5580
gattggcctg tcctgcaggg gcgtcccgcg gtcctcctcg tagagaaact cggaccactc 5640
tgagacaaag gcgcgcgtcc acgccaagac aaaggaggcc acgtgcgagg ggtagcggtc 5700
gttgtccact agggggtcca ccttttccac cgtgtgcaga cacatgtccc cctcctccgc 5760
atccaagaag gtgattggct tgtaggtgta ggccacgtga ccgggggtcc ccgacggggg 5820
ggtataaaag ggggcgggtc tgtgctcgtc ctcactctct tccgcgtcgc tgtccacgag 5880
cgccagctgt tggggtaggt attccctctc gagagcgggc atgacctcgg cactcaggtt 5940
gtcagtttct agaaacgagg aggatttgat gttggcttgc cctgccgcga tgctttttag 6000
gagactttca tccatctggt cagaaaagac tattttttta ttgtcaagct tggtggcgaa 6060
ggagccatag agggcgttgg atagaagctt ggcgatggat ctcatggtct gatttttgtc 6120
acggtcggcg cgctccttgg ccgcgatgtt tagctggaca tactcgcgcg cgacgcactt 6180
ccattcgggg aagacggtgg tgcgctcgtc gggcacgatc ctgacgcgcc agccgcggtt 6240
atgcagggtg accaggtcca cgctggtggc cacctcgccg cgcaggggct cgttggtcca 6300
gcagagtctg ccgcccttgc gcgagcagaa cgggggcagc acatcaagca gatgctcgtc 6360
aggggggtcc gcatcgatgg tgaagatgcc cggacagagt tccttgtcaa aataatcgat 6420
ttttgaggat gcatcatcca aggccatctg ccactcgcgg gcggccagcg ctcgctcgta 6480
ggggttgagg ggcggacccc agggcatggg atgagtgagg gcggaggcgt acatgccgca 6540
gatgtcgtag acatagatgg gctccgagag gatgccgatg taggtgggat aacagcgccc 6600
cccgcggatg ctggcgcgca cgtagtcata caactcgtgc gagggggcca agaaggcggg 6660
gccgagattg gtgcgctggg gctgctcggc gcggaagacg atctggcgaa agatggcgtg 6720
cgagttggag gagatggtgg gccgttggaa gatgttaaag tgggcgtggg gcaagcggac 6780
cgagtcgcgg atgaagtgcg cgtaggagtc ttgcagcttg gcgacgagct cggcggtgac 6840
gaggacgtcc atggcgcagt agtccagcgt ttcgcggatg atgtcataac ccgcctctcc 6900
tttcttctcc cacagctcgc ggttgagggc gtactcctcg tcatccttcc agtactcccg 6960
gagcgggaat cctcgatcgt ccgcacggta agagcccagc atgtagaaat ggttcacggc 7020
cttgtaggga cagcagccct tctccacggg gagggcgtaa gcttgagcgg ccttgcggag 7080
cgaggtgtgc gtcagggcga aggtgtccct gaccatgact ttcaagaact ggtacttgaa 7140
atccgagtcg tcgcagccgc cgtgctccca gagctcgaaa tcggtgcgct tcttcgagag 7200
ggggttaggc agagcgaaag tgacgtcatt gaagagaatc ttgcctgctc gcggcatgaa 7260
attgcgggtg atgcggaaag ggcccgggac ggaggctcgg ttgttgatca cctgggcggc 7320
aaggacgatc tcgtcgaagc cgttgatgtt gtgcccgacg atgtagagtt ccatgaatcg 7380
cgggcggcct ttgatgtgcg gcagcttttt gagctcctcg taggtgaggt cctcggggca 7440
ttgcaggccg tgctgctcta gcgcccactc ctggagatgt gggttggctt gcatgaagga 7500
agcccagagc tcgcgggcca tgagggtctg gagctcgtcg cgaaagaggc ggaactgctg 7560
gcccacggcc atcttttctg gggtgacgca gtagaaggtg agggggtccc gctcccagcg 7620
atcccagcgt aagcgcacgg cgagatcgcg agcgagggcg accagctcgg gttcccccga 7680
gaatttcatg accagcatga aggggacgag ctgcttgccg aaggacccca tccaggtgta 7740
ggtttctaca tcgtaggtga caaagagccg ctccgtgcga ggatgagagc cgattgggaa 7800
gaactggatt tcctgccacc agttggacga gtggctgttg atgtgatgaa agtagaaatc 7860
ccgccggcga accgagcact cgtgctgatg cttgtaaaag cgtccgcagt actcgcagcg 7920
ctgcacgggc tgtacctcat ccacgagata cacagcgcgt cccttgagga ggaacttcag 7980
gagtggcggc cctggctggt ggctttcatg ttcgcctgcg tgggactcac cctggggctc 8040
ctcgaggacg gagaggctga cgagcccgcg cgggagccag gtccagatct cggcgcggcg 8100
ggggcggaga gcgaagacga gggcgcgcag ttgggagctg tccatggtgt cgcggagatc 8160
caggtccggg ggcagggttc tgaggttgac ctcgtagagg cgggtgaggg cgtgcttgag 8220
atgcagatgg tacttgatct ccacgggtga gttggtggtc gtgtccacgc attgcatgag 8280
cccgtagctg cgcggggcca cgaccgtgcc gcggtgcgct tttagaagcg gtgtcgcggg 8340
cgtgctcccg gcggcagcgg cggttctggc cccgcgggca ggggcggcag aggcacgtcg 8400
gcgtggcgct cgggcaggtc ccggtgctgc gccctgagag cgctggcgtg cgcgacgacg 8460
cggcggttga catcctggat ctgccgcctc tgcgtgaaga ccacgggccc cgtgactttg 8520
aacctgaaag acagttcaac agaatcaatc tctgcgtcat tgacggcggc ctgacgcagg 8580
atctcttgca cgtcgcccga gttgtcctgg taggcgatct cggtcatgaa ctgttcgatc 8640
tcctcctcct ggagatcgcc gcggcccgcg cgctccacgg tggcggcgag gtcattggag 8700
atgcggccca tgagctgcga gaaggcgccc aggccgctct cgttccagac gcggctgtag 8760
accacgtccc cgtcggcgtc gcgtgcgcgc atgaccacct gcgcgaggtt gagctccacg 8820
tgccgcgtga agacggcgta gttgcgcagg cgctggaaga ggtagttgag ggtggtggcg 8880
atgtgctcgg tgacgaagaa gtacatgatc cagcggcgca ggggcatctc gctgatgtcg 8940
ccgatggcct ccagcctttc catggcctcg tagaaatcca cggcgaagtt gaaaaactgg 9000
gcattgcggg ccgagaccgt gagctcgtct tccaggagcc ggatgagctc ggcgatggtg 9060
gcgcgcacct cgcgctcgaa atccccgggg gcctcctctt cttcctcttc ttccatgacg 9120
acctcttctt ctatttcttc ctctgggggc ggtggtggtg gcggggcccg acgacgacgg 9180
cgacgcaccg ggagacggtc gacgaagcgc tcgatcatct ccccgcggcg gcgacgcatg 9240
gtttcggtga cggcgcgacc ccgttcgcga ggacgcagcg tgaagacgcc gccggtcatc 9300
tcccggtaat ggggcgggtc cccgttgggc agcgataggg cgctgacgat gcatcttatc 9360
aattgcggtg taggggacgt gagcgcgtcg agatcgaccg gatcggagaa tctttcgagg 9420
aaagcgtcta gccaatcgca gtcgcaaggt aagctcaaac acgtagcagc cctgtggacg 9480
ctgttagaat tgcggttgct gatgatgtaa ttgaagtagg cgtttttgag gcggcggatg 9540
gtggcgagga ggaccaggtc cttgggtccc gcttgctgga tgcggagccg ctcggccatg 9600
ccccaggcct ggccctgaca ccggctcagg ttcttgtagt agtcatgcat gagcctctcg 9660
atgtcatcac tggcggaggc ggagtcttcc atgcgggtga ccccgacgcc cctgagcggc 9720
tgcacgagcg ccaggtcggc gacgacgcgc tcggcgagga tggcctgttg cacgcgggtg 9780
agggtgtcct ggaagtcgtc catgtcgaca aagcggtggt aggccccggt gttgatggtg 9840
taggtgcagt tggccatgag cgaccagttg acggtctgca ggccgggttg cacgacctcg 9900
gagtacctga gccgcgagaa ggcgcgcgag tcgaagacgt agtcattgca ggtgcgcacg 9960
aggtactggt agccgactag gaagtgcggc ggcggctggc ggtagagcgg ccagcgctgg 10020
gtggccggcg cgcccggggc caggtcctcg agcatgaggc ggtggtagcc gtagaggtag 10080
cgggacatcc aggtgatgcc ggcggcggtg gtggaggcgc gcgggaactc gcggacgcgg 10140
ttccagatgt tgcgcagcgg caggaaatag tccatggtcg gcacggtctg gccggtgaga 10200
cgcgcgcagt cattgacgct ctagaggcaa aaacgaaagc ggttgagcgg gctcttcctc 10260
cgtagcctgg cggaacgcaa acgggttagg ccgcgtgtgt accccggttc gagtcccctt 10320
gaatcaggct ggagccgcga ctaacgtggt attggcactc ccgtctcgac ccgagcccga 10380
tagccgccag gatacggcgg agagtccttt ttgccggcca aggggggtcg ctagacttga 10440
aagcgaccga aaaccctgcc gggtagtggc tcgcgcccgt agtctggaga agcatcgcca 10500
gggttgagtc gcggcagaac ccggttcgcg gacggccgcg gcgagcggga cttggtcacc 10560
ccgccgattt aaagacccac agccagccga cttctccagt tacgggagcg agcccccttt 10620
tttctttttg ccagatgcat cccgtcctgc gccaaatgcg tcccaccccc ccggcgacca 10680
ccgcgaccgc ggccgtagca ggcgccggcg ctagccagcc acagccacag acagagatgg 10740
acttggaaga gggcgaaggg ctggcgagac tgggggcgcc gtccccggag cgacaccccc 10800
gcgtgcagct gcagaaggac gtgcgcccgg cgtacgtgcc tgcgcagaac ctgttcaggg 10860
accgcagcgg ggaggagccc gaggagatgc gcgactgccg gtttcgggcg ggcagggagc 10920
tgcgcgaggg cctggaccgc cagcgcgtgc tgcgcgacga ggatttcgag ccgaacgagc 10980
agacggggat cagccccgcg cgcgctcacg tggcggcggc caacctggtg acggcctacg 11040
agcagacggt gaagcaggag cgcaacttcc aaaagagttt caacaaccac gtgcgcaccc 11100
tgatcgcgcg cgaggaggtg gccctgggcc tgatgcacct gtgggacctg gcggaggcca 11160
tcgtgcagaa cccggacagc aagcctctga cggcgcagct gttcctggtg gtgcagcaca 11220
gcagggacaa cgaggcgttc agggaggcac tgctgaacat cgccgagccc gagggtcgct 11280
ggctgctgga gctgatcaac atcttgcaga gcatcgtagt gcaggagcgc agcctgagct 11340
tggccgagaa ggtggcggcg atcaactact cggtgctgag cctgggcaag ttttacgcgc 11400
gcaagattta caagacgccg tacgtgccca tagacaagga ggtgaagata gacagctttt 11460
acatgcgcat ggcgctcaag gtgctgacgc tgagcgacga cctgggcgtg taccgcaacg 11520
accgcatcca caaggccgtg agcacgagcc ggcggcgcga gctaagcgac cgcgagctga 11580
tgctgagcct gcgccgggcg ctggtagggg gcgctgccgg cggcgaggag tcctacttcg 11640
acatgggggc ggacctgcat tggcagccga gccggcgcgc cttggaggcc gcctacggtc 11700
cagaggactt ggatgaggaa gaggaagagg aggaggatgc acccgctgcg gggtactgac 11760
gcctccgtga tgtgttttta gatgcagcaa gccccggacc ccgccataag ggcggcgctg 11820
caaagccagc cgtccggtct agcatcggac gactgggagg ccgcgatgca acgcatcatg 11880
gccctgacga cccgcaaccc cgagtccttt agacaacagc cgcaggccaa cagactctcg 11940
gccattctgg aggcggtggt cccctctcgg accaacccca cgcacgagaa ggtgctggcg 12000
atcgtgaacg cgctggcgga gaacaaggcc atccgtcccg acgaggccgg gctggtgtac 12060
aacgccctgc tggagcgcgt gggccgctac aacagcacga acgtgcagtc caacctggac 12120
cggctggtga cggacgtgcg cgaggccgtg gcgcagcgcg agcggttcaa gaacgagggc 12180
ctgggctcgc tggtggcgct gaacgccttc ctggcgacgc agccggcgaa cgtgccgcgc 12240
gggcaggacg attacaccaa ctttatcagc gcgctgcggc tgatggtgac cgaggttccc 12300
cagagcgagg tgtaccagtc gggcccggac tactttttcc agacgagccg gcagggcttg 12360
cagacggtga acctgagcca ggctttcaag aacctgcgag ggctgtgggg cgtgcaggcg 12420
cccgtgggcg accggtcgac ggtgagcagc ttgctgacgc ccaactcgcg gctgctgctg 12480
ctgctgatcg cgcccttcac cgacagcggc agcgtgaacc gcaactcgta cctgggccat 12540
ctgctgacgc tgtaccgcga ggccataggc caggcgcagg tggacgagca gaccttccag 12600
gagatcacta gcgtgagccg cgcgctgggg cagaacgaca ccgacagtct gagggccacc 12660
ctgaacttct tgctgaccaa tagacagcag aagatcccgg cgcaatatgc gctgtcggcc 12720
gaggaggaaa ggatcctgag atatgtgcag cagagcgtag ggctgttcct gatgcaggag 12780
ggggccaccc ccagcgccgc gctggacatg accgcgcgca acatggaacc tagcatgtac 12840
gccgccaacc ggccgttcat caataagctg atggactacc tgcaccgcgc ggcggtcatg 12900
aacacggact actttacaaa cgccatcctg aacccgcact ggctcccgcc gccggggttc 12960
tacacgggcg agtacgacat gcccgacccc aacgacgggt tcctgtggga cgacgtggac 13020
agcgtggtgt tctcgccgac ctttcaaaag cgccaggagg cgccgccgag cgagggcgcg 13080
gtggggagga gcccctttcc tagcttaggg agtttgcata gcttgccggg ctcggtgaac 13140
agcggcaggg tgagccggcc gcgcttgctg ggcgaggacg agtacctgaa cgactcgctg 13200
ctgcagccgc cgcgggccaa gaacgccatg gccaataacg ggatagagag tctggtggac 13260
aaactgaacc gttggaagac ctacgctcag gaccataggg atgcgcccgc gccgcggcga 13320
cagcgccacg accggcagcg gggcctggtg tgggacgacg aggactcggc cgacgatagc 13380
agcgtgttgg acttgggcgg gagcggtggg gtcaacccgt tcgcgcatct gcagcccaaa 13440
ctggggcgac ggatgttttg aaatgcaaaa taaaactcac caaggccata gcgtgcgttc 13500
tcttccttgt tagagatgag gcgtgcggtg gtgtcttcct ctcctcctcc ctcgtacgag 13560
agcgtgatgg cgcaggcgac cctggaggtt ccgtttgtgc ctccgcggta tatggctcct 13620
acggagggca gaaacagcat tcgttactcg gagctggctc cgcagtacga caccactcgc 13680
gtgtacttgg tggacaacaa gtcggcggac atcgcttccc tgaactacca aaacgaccac 13740
agcaacttcc tgaccacggt ggtgcagaac aacgatttca cccccgccga ggccagcacg 13800
cagacgataa attttgacga gcggtcgcgg tggggcggtg atctgaagac cattctgcac 13860
actaacatgc ccaatgtgaa cgagtacatg ttcaccagca agtttaaggc gcgggtgatg 13920
gtggctagga agcatccaga gggggtagtt gaaacagatt tgagtcagga taagcttgaa 13980
tatgagtggt ttgagtttac cctgcccgag ggaaactttt ccgagaccat gaccatagac 14040
ctgatgaaca acgccatctt ggaaaactac ttgcaagtgg ggcggcaaaa tggcgtgctg 14100
gagagcgata tcggagtcaa gtttgacagc agaaatttca agctgggctg ggacccggtg 14160
accaagctgg tgatgccagg ggtctacacc tacgaggcct tccacccgga cgtggtgctg 14220
ctgccgggct gcggggtgga cttcaccgag agccgcctga gcaacctcct gggcattcgc 14280
aagaagcaac ctttccaaga gggcttcaga atcatgtatg aggatctaga aggtggcaac 14340
atccccgccc tccttgatgt gcccaagtac ttggaaagca agaagaaagt tgaagacgaa 14400
actaaaaatg cagctgcggc tacagccgat acaaccacta ggggtgatac atttgcaact 14460
ccagcgcaag agacagcagc tgataagaag gtagaagtct tgcccattga aaaggatgag 14520
agtggtagaa gttacaacct gatccagggg acccacgaca cgctgtaccg cagttggtac 14580
ctgtcctata cctacgggga ccccgagaag ggggtgcagt cgtggacgct gctcaccacc 14640
ccggacgtca cctgcggcgc ggagcaagtc tactggtcgc tgccggacct catgcaagac 14700
ccagtcacct tccgctctac ccagcaagtc agcaactacc ccgtggtcgg cgccgagctc 14760
atgcccttcc gcgccaagag cttttacaac gacctcgccg tctactccca gctcatccgc 14820
agctacacct ccctcaccca cgtcttcaac cgcttccccg acaaccagat cctctgccgc 14880
ccgcccgcgc ccaccatcac caccgtcagt gaaaacgtgc ctgctctcac agatcacggg 14940
acgctaccgc tgcgcagcag tatccgcgga gtccagcgag tgaccgtcac tgacgcccgt 15000
cgccgcacct gtccctacgt ctacaaggcc ctgggcatag tcgcgccgcg cgtgctttcc 15060
agtcgcacct tctaaaaaaa tgtctattct catctcgccc agcaataaca ccggctgggg 15120
tcttactaga cccagcacca tgtacggagg agccaagaag cgctcccagc agcaccccgt 15180
ccgcgtccgc ggccacttcc gcgctccctg gggcgcttac aagcgcgggc ggacttccac 15240
cgccgtgcgc accaccgtcg acgacgtcat cgactcggtg gtcgccgacg cgcgcaacta 15300
tacccccgcc ccctccaccg tggacgcggt catcgacagc gtggtggccg acgcgcgcga 15360
ctatgccaga cgcaagagcc ggcggcgacg gatcgccagg cgccaccgga gcacgcccgc 15420
catgcgcgcc gcccgggctc tgctgcgccg cgccagacgc acgggccgcc gggccatgat 15480
gcgagccgcg cgccgcgctg ccactgcacc cacccccgca ggcaggactc gcagacgagc 15540
ggccgccgcc gccgccgcgg ccatctctag catgaccaga cccaggcgcg gaaacgtgta 15600
ctgggtgcgc gactccgtca cgggcgtgcg cgtgcccgtg cgcacccgtc ctcctcgtcc 15660
ctgatctaat gcttgtgtcc tcccccgcaa gcgacgatgt caaagcgcaa aatcaaggag 15720
gagatgctcc aggtcgtcgc cccggagatt tacggaccac cccaggcgga ccagaaaccc 15780
cgcaaaatca agcgggttaa aaaaaaggat gaggtggacg agggggcagt agagtttgtg 15840
cgcgagttcg ctccgcggcg gcgcgtaaat tggaaggggc gcagggtgca gcgcgtgttg 15900
cggcccggca cggcggtggt gttcacgccc ggcgagcggt cctcagtcag gagcaagcgt 15960
agctatgacg aggtgtacgg cgacgacgac atcctggacc aggcggcgga gcgggcgggc 16020
gagttcgcct acgggaagcg gtcgcgcgaa gaggagctga tctcgctgcc gctggacgaa 16080
agcaacccca cgccgagcct gaagcccgtg accctgcagc aggtgctgcc ccaggcggtg 16140
ctgctgccga gccgcggggt caagcgcgag ggcgagagca tgtacccgac catgcagatc 16200
atggtgccca agcgccggcg cgtggaggac gtgctggaca ccgtgaaaat ggatgtggag 16260
cccgaggtca aggtgcgccc catcaagcag gtggcgccgg gcctgggcgt gcagaccgtg 16320
gacattcaga tccccaccga catggatgtc gacaaaaaac cctcgaccag catcgaggtg 16380
cagaccgacc cctggctccc agcctccact gctaccgtct ccacttctac cgccgccacg 16440
gctaccgagc ctcccaggag gcgaagatgg ggcgccgcca gccggctgat gcccaactac 16500
gtggtgcatc cttccatcat cccgacgccg ggctaccgcg gcacccggta ctacgccagc 16560
cgccggcgcc cagccagcaa acgccgccgc cgcaccgcca cccgccgccg tctggccccc 16620
gcccgcgtgc gccgcgtgac cacgcgccgg ggccgctcgc tcgttctgcc caccgtgcgc 16680
taccacccca gcatccttta attcgtgtgc tgtgatactg ttgcagagag atggctctca 16740
cttgccgcct gcgcatcccc gtcccgaatt accgaggaag atcccgccgc aggagaggca 16800
tggcaggcag cggcctgaac cgccgccggc ggcgggccat gcgcaggcgc ctgagtggcg 16860
gctttctgcc cgcgctcatc cccataatcg ccgcggccat cggcacgatc ccgggcatag 16920
cttccgttgc gctgcaggcg tcgcagcgcc gttgatgtgc gaataaaagc ctctttagac 16980
tctgacacac ctggtcctgt atatttttag aatggaagac atcaattttg cgtccctggc 17040
tccgcggcac ggcacgcggc cgttcatggg cacctggaac gagatcggca ccagccagct 17100
gaacgggggc gccttcaatt ggagcagtgt ctggagcggg cttaaaaatt tcggctcgac 17160
gctccggacc tatgggaaca aggcctggaa tagtagcacg gggcagttgc taagggaaaa 17220
gctcaaagac cagaactttc agcagaaggt ggtggacggg ctggcctcgg gcattaacgg 17280
ggtggtggac atcgcgaacc aggccgtgca gcgcgagata aacagccgcc tggacccgcg 17340
gccgcccacg gtggtggaga tggaagatgc aactcttccg ccgcccaaag gcgagaagcg 17400
gccgcggccc gacgcggagg agacgatcct gcaggtggac gagccgccct cgtacgagga 17460
ggccgtcaag gccggcatgc ccaccacgcg catcatcgcg ccgctggcca cgggtgtaat 17520
gaaacccgcc acccttgacc tgcctccacc acccgcgccc gctccaccga aggcagctcc 17580
cgcggtcgtg caggcccccc cggtggcgac cgccgtgcgc cgcgtccccg cccgccgcca 17640
ggcccagaac tggcagagca cgttgcacag tatcgtaggc ctgggagtga aaagtctgaa 17700
gcgccgccga tgctattgaa agagaggaaa gaggacacta aagggagagc ttaacttgta 17760
tgtgccttac cgccagagaa cgcgcgaaga tggccacccc ctcgatgatg ccgcagtggg 17820
cgtacatgca catcgccggg caggacgcct cggagtacct gagcccgggt ctggtgcagt 17880
ttgcccgcgc caccgacacg tacttcagcc tgggcaacaa gtttaggaac cccacggtgg 17940
ccccgaccca cgatgtgacc acggaccggt cccagcgtct gacgctgcgc ttcgtgcccg 18000
tggatcgcga ggacaccacg tactcgtaca aggcgcgctt cactctggcc gtgggcgaca 18060
accgggtgct agacatggcc agcacttact ttgacatccg cggcgtcctg gaccgcggtc 18120
ccagcttcaa accctactcg ggcacagctt acaacagtct ggcccccaag ggtgccccca 18180
actccagcca gtggcttgca aaagacacca atgctggcga tcaagcatta aaaacccaca 18240
cacatggcgt agctgctatg gggggaacag atatcacagc aaagggtttg caaattggtg 18300
ttgacacgac tgaaaacaag aatgagccta tttatgcaaa tgaaatatac cagccagaac 18360
ctcaggtagg agaggaaaac ttgcaagatg ttgaaaactt ttatggaggc agagctctta 18420
aaaaagaaac caaaatgaaa ccttgctatg gctcgtttgc cagacccaca aatgaaaaag 18480
gcggtcaagc caaattttta actgacggcg atggtcagct aactaaaaat catgatatca 18540
caatgaattt ctttgacact cctggaggaa cagttggtca ggatactgaa cttgaagcag 18600
acattgttat gtatgctgag aatgtgcatc tggaaactcc agacacgcat gtggtgtaca 18660
aaccaggaac ttctgatgag agttcagaag caaatttggt tcagcagtcc atgccaaaca 18720
ggcccaacta catcggcttc agggacaact ttgtgggtct catgtactat aacagcactg 18780
gcaacatggg tgtgctggct ggtcaagcat ctcagttgaa tgctgtggtc gacttgcaag 18840
acagaaacac agagctgtct taccagctct tgctagattc tctgggtgac agaaccagat 18900
actttagcat gtggaactct gcagtggaca gttatgatcc tgatgtcagg attattgaaa 18960
atcacggtgt ggaagatgaa cttccaaact attgcttccc attggatgga gctggcacta 19020
atgctaccta ccaaggtgta aaagttaaaa atggccaaga tggagatgta aacgcagatt 19080
gggaaaaaga tccaaatctt gcttcacgaa accaaatatg caagggtaac atcttcgcca 19140
tggagatcaa cctccaggcc aacctgtgga agagttttct gtactcgaat gtggccctgt 19200
acctgcccga ctcatacaag tacacgccgg ccaacgtcac gctgcccgcc aataccaaca 19260
cctacgagta catgaacggc cgcgtggtag ccccctcgct ggtggacgcc tacatcaaca 19320
tcggcgcccg gtggtcgctg gaccccatgg acaacgtcaa cccattcaac caccaccgca 19380
acgcgggcct gcgttaccgc tccatgcttc tgggcaacgg ccgctacgtg cccttccaca 19440
tccaagtgcc ccaaaagttc tttgccatca agaacctgct cctgctcccc ggctcctaca 19500
cctacgagtg gaacttccgc aaggatgtca acatgatcct gcagagttcc ctcggaaacg 19560
acctgcgcgt cgacggcgcc tccgtccgct tcgacagcgt caacctctac gccacattct 19620
tccccatggc gcacaacacc gcctccaccc tggaagccat gctgcgcaac gacaccaacg 19680
accagtcctt caacgactac ctctcggccg ccaacatgct ctaccccatc ccggccaagg 19740
ccaccaacgt gcccatctcc atcccctcgc gcaactgggc cgccttccgc ggctggagtt 19800
tcacccggct caagaccaaa gaaactccct ccctcggctc gggtttcgat ccctactttg 19860
tatactcggg ttccatcccc tacctcgacg ggaccttcta cctcaaccac accttcaaga 19920
aggtctccat catgttcgac tcctcggtca gctggcccgg caacgaccgg ctgctcacgc 19980
cgaacgagtt cgagatcaag cgcagtgtcg acggggaggg ctacaatgtg gcccaatgca 20040
acatgaccaa ggactggttc ctcgtccaga tgctctccca ctacaacatc ggctaccagg 20100
gcttccacgt gcccgagggc tacaaggacc gcatgtactc cttcttccgc aacttccagc 20160
ccatgagcag gcaggtggtc gatgagatca actacaagga ctacaaggcc gtcaccctgc 20220
ccttccagca caacaactcg ggcttcaccg gctaccttgc acccaccatg cgtcaggggc 20280
agccctaccc cgccaacttc ccctatcctc tcatcggcca gacagccgtg ccctctgtca 20340
cccagaaaaa gttcctctgc gacagggtca tgtggcgcat ccccttctcc agcaacttca 20400
tgtccatggg cgccctcacc gacctgggtc agaacatgct ctatgccaac tcggcccacg 20460
cgctcgacat gaccttcgag gtggacccca tggatgagcc caccctcctc tatcttctct 20520
tcgaagtttt cgacgtggtc agagtgcacc agccgcaccg cggcgtcatc gaggccgtct 20580
acctgcgcac gcccttctcc gccggcaacg ccaccaccta agcatgagcg gctccagcga 20640
acgagagctc gcggccatcg tgcgcgacct gggctgcggg ccctactttt tgggcaccca 20700
cgacaagcgc ttcccgggct tcctcgccgg cgacaagctg gcctgcgcca ttgtcaacac 20760
ggccggccgc gagaccggag gcgtgcactg gctcgccttc ggctggaacc cgcgctcgcg 20820
cacctgctac atgttcgacc catttgggtt ctcggaccgc cggctcaagc agatttacag 20880
cttcgagtac gaggctatgt tgcgccgaag cgccctggct tcctcgcccg accgctgtct 20940
cagcctcgag cagtccaccc agaccgtgca ggggcccgac tccgccgcct gcggactttt 21000
ctgttgcatg ttcttgcatg ccttcgtgca ctggcccgac cgacccatgg acgggaaccc 21060
caccatgaac ttgctgacgg gggtgcccaa cggcatgcta caatcgccac aggtgctgcc 21120
caccctccgg cgcaaccagg aggagctcta ccgcttcctc gcgcgccact ccccttactt 21180
tcgctcccac cgcgccgcca tcgaacacgc caccgctttt gacaaaatga aacaactgcg 21240
tgtatctcaa taaacagcac ttttatttta catgtactgg agtatatgca agttatttaa 21300
aagtcgaagg ggttctcgcg ctcgtcgttg tgcgccgcgc tggggagggc cacgttgcgg 21360
tactggaact tgggctgcca cttgaactcg gggatcacca gtttgggcac tggggtctcg 21420
gggaaggtct cgctccacat gcgccggctc atctgcaggg cgcccagtat gtccggggcg 21480
gagatcttga aatcgcagtt ggggccggtg ctctgcgcgc gcgagttgcg gtacacgggg 21540
ttgcagcact ggaacaccat cagactgggg tacttcacac tggccagcac gctcttgtcg 21600
ctgatctgat ccttgtccag gtcctcggcg ttgctcaggc cgaacggggt catcttgcac 21660
agctggcggc ccaggaaggg cacgctctga ggcttgtggt tacactcgca gtgcacgggc 21720
atcagcatca tccccgcgcc gcgctgcata ttcgggtaga gggccttgac aaaggccgag 21780
atctgcttga aagcttgctg ggccttggcc ccctcgctga aaaacaggcc gcagctcttc 21840
ccgctgaact ggttattccc gcacccggca tcatgcacgc agcagcgcgc gtcatggctg 21900
gtcagttgca ccacgctccg tccccagcgg ttctgggtca ccttggcctt gctaggctgc 21960
tccttcaacg cgcgctggcc gttctcgctg gtcacatcca tctccaccac gtggtccttg 22020
tggatcatca ccgtcccgtg caaacacttg agctggcctt ccacctcggt gcagccgtga 22080
tcccacaggg cgcagccggt gcactcccaa ttcttgtgtg cgatcccgct gtggctgaag 22140
atgtaacctt gcaacaggcg acccatgacg gtgctaaatg atttactggt gctgaaggtc 22200
agttgcagac cgcgggcctc ctcgttcatc caggtctggc acatcttttg gaagatctcg 22260
gtctgctcgg gcatgagctt gtaagcatcg cgcaggccgc tgtcgacgcg gtagcgttcc 22320
ataagcacgt tcatggtatc catgcccttc tcccaggacg agaccagagg cagactcagg 22380
gggttgcgca cgttcagaat accgggggtc gcgggctcga cgatgcgttt tccgtccttg 22440
ccttccttca acagaaccgg cggctggctg aatcccactc ccacgatcac ggcatcttcc 22500
tggggcatct cttcgtcggg gtctaccttg gtcacatgct tggtctttct ggcttgcttc 22560
ttttttggag ggctgtccac ggggaccacg tcctcctcgg aagacccgga gcccacccgc 22620
tgatactttc ggcgcttggt gggcagagga ggtggaggcg aggggctcct ctcctgctcc 22680
ggcggatagc gcgccgaccc gtggccccgg ggcggagtgg cctctcgctc catgaaccgg 22740
cgcacgtcct gactgccgcc ggccattgtt tcctagggga agatggagga gcagccgcgt 22800
aagcaggagc aggaggagga cttaaccacc cacgagcaac ccaaaatcga gcaggacctg 22860
ggcttcgaag agccggctcg tctagaaccc ccacaggatg aacaggagca cgagcaagac 22920
gcaggccagg aggagaccga cgctgggctc gagcatggct acctgggagg agaggaggat 22980
gtgctgctga aacacttgca gcgccagtcc ctcatcctcc gggacgccct ggccgaccgg 23040
agcgaaaccc ccctcagcgt cgaggagctg tgtcgggcct acgagctcaa cctcttctcg 23100
ccgcgcgtgc cccccaaacg ccagcccaac ggcacctgcg agcccaaccc gcgtctcaac 23160
ttctatcccg ttttcgcggt ccccgaggcc cttgccacct atcacatttt tttcaagaac 23220
caaaagatcc ccgtctcctg ccgcgccaac cgcacccgcg ccgacgcgct cctcgctctg 23280
gggcccggcg cgcgcatacc tgatatcgct tccctggaag aggtgcccaa gatcttcgaa 23340
gggctcggtc gggacgagac gcgcgcggcg aacgctctga aagaaacagc agaggaagag 23400
ggtcacacta gcgccctggt agagttggaa ggcgacaacg ccaggctggc cgtgctcaag 23460
cgcagcgtcg agctcaccca ctttgcctac cccgccgtca acctcccgcc caaggtcatg 23520
cgtcacatca tggatcagct catcatgccc cacatcgaag ccctcgatga aagtcaggag 23580
cagcgccccg aggacgcccg acccgtggtc agcgacgaga tgctcgcgcg ctggctcggg 23640
acccgcgagc cccaggcttt ggaacagcgg cgcaagctca tgctggccgt ggtcctggtc 23700
accctcgagc tcgaatgcat gcgccgcttc ttcagcgacc ccgagaccct gcgcaaagtc 23760
gaggagaccc tgcactacac tttcagacac ggtttcgtca ggcaggcctg caagatttcc 23820
aacgtggagc tgaccaacct ggtctcctgc ctggggatcc tgcatgagaa ccgcctggga 23880
cagaccgtac tccactctac cctgaagggc gaggcgcgga gggactatgt ccgcgactgc 23940
gtctttctct ttctctgcca cacatggcaa gcagccatgg gcgtgtggca gcagtgtctc 24000
gaggacgaga acctgaagga gctggacaag cttcttgcta gaaaccttaa aaagctttgg 24060
acgggcttcg acgagcgcac cgtcgcctcg gacctggccg agatcgtctt ccccgagcgc 24120
ctgaggcaga cgctgaaagg cgggctgccc gacttcatga gccagagcat gttgcaaaac 24180
taccgcactt tcattctcga gcgatcgggg atgctgcccg ccacctgcaa cgctttcccc 24240
tccgactttg tcccgctgag ctaccgcgag tgtcccccgc cgctgtggag ccactgctac 24300
ctcttgcagc tggccaacta catcgcctac cactcggacg tgatcgagga cgtgagcggc 24360
gaggggctgc tcgagtgcca ctgccgctgc aacctgtgct ccccgcaccg ctccctggtc 24420
tgcaaccccc agctccttag cgagacccag gtcatcggta ccttcgagct gcaaggtccg 24480
caggagtcca ccgctccgct gaaactcacg ccggggttgt ggacttccgc gtacctgcgc 24540
aaatttgtac ccgaggacta ccacgcccat gagataaagt tcttcgagga ccaatcgcgg 24600
ccgcagcacg cggatctcac ggcctgcgtc atcacccagg gcgcgatcct cgcccaattg 24660
cacgccatcc aaaaatcccg ccaagagttt cttctgaaaa agggtagagg ggtctacctg 24720
gacccccaga cgggcgaggt gctcaacacg ggtctccccc agcatgccga ggaagaagca 24780
ggagccgcta gtggaggaga tggaagaaga atgggacagc caggcagagg aggacgaatg 24840
ggaggaggag acagaggagg aagaattgga agaggtggaa gaggagcagg caacagagca 24900
gcccgtcgcc gcaccatccg cgccggcagc cccggcggtc acggatacaa cctccgcagc 24960
tccggccaag cctcctcgta gatgggatcg agtgaagggc gacggtaagc acgagcggca 25020
gggctaccga tcatggaggg cccacaaagc cgcgatcatc gcctgcttgc aagactgcgg 25080
ggggaacatc gctttcgccc gccgctacct gctcttccac cgcggggtga acatcccccg 25140
caacgtgttg cattactacc gtcaccttca cagctaagaa aaagcaagta agagaagtcg 25200
ccggaggagg cctgaggatc gcggcgaacg agcccttgac caccagggag ctgaggaacc 25260
ggatcttccc cactctttat gccatttttc agcagagtcg aggtcagcag caagagctca 25320
aagtaaaaaa ccggtctctg cgctcgctca cccgcagttg cttgtaccac aaaaacgaag 25380
atcagctgca gcgcactctc gaagacgccg aggctctgtt ccacaagtac tgcgcgctca 25440
ctcttaaaga ctaaggcgcg cccacccgga aaaaaggcgg gaattacctc atcgccacca 25500
tgagcaagga gattcccacc ccttacatgt ggagctatca gccccagatg ggcctggccg 25560
cgggcgcctc ccaagactac tccacacgca tgaactggct cagtgccggc ccctcgatga 25620
tatcacgggt caacggggtc cgcagtcatc gaaaccagat attgttggag caggcggcgg 25680
tcacctccac gcccagggca aagctcaacc cgcgtaattg gccctccacc ctggtgtatc 25740
aggaaatccc cgggccgact accgtactac ttccgcgtga cgcactggcc gaagtccgca 25800
tgactaactc aggtgtccag ctggccggcg gcgcttcccg gtgcccgctc cgcccacaat 25860
cgggtataaa aaccctggtg atccgaggca gaggcacaca gctcaacgac gagttggtga 25920
gctcttcgat cggtctgcga ccggacggag tgttccaact agccggagcc gggagatcgt 25980
ccttcactcc caaccaggcc tacctgacct tgcagagcag ctcttcggag cctcgctcgg 26040
gaggcatcgg aaccctccag ttcgtggagg agtttgtgcc ctcggtctac ttcaacccct 26100
tctcgggatc gccaggcctc tacccggacg agttcatacc gaacttcgac gcagtgagag 26160
aagcggtgga cggctacgac tgaatgtccc atggtgactc tgctgagctc gctcggttga 26220
ggcatctgga ccactgccgc cgcctgcgct gcttcgcccg ggagagctgc ggactcatct 26280
actttgagtt tcccgaggag caccccaacg gtcctgcaca cggagtgcgg atcaccgtag 26340
agggcaccac cgagtctcac ctggtcaggt tcttcaccca gcaacccttc ctggtcgagc 26400
gggaccgggg cgccaccacc tacaccgtct actgcatctg tccgaccccg aagttgcatg 26460
agaatttttg ctgtactctt tgtggtgagt ttaataaaag ctaaactctt gcaatactct 26520
ggaccttgtc gtcatcaact caacgagacc gtctacctca ccaaccagac tgaggtaaaa 26580
ctcacctgca gaccacacaa gacctatatc atctggttct tcgagaacac ctcatttgca 26640
gtctcaaaca ctcactgcaa cgacggtgtt gaacttccaa acaacctttc cagtggactg 26700
agttacgata cacatagagc taagctcgtc ctctacaatc ctttcgtaga gggaacctac 26760
cactgccaga gcggaccttg cttccacagt tttactttgg tgaacgttac cggcagcagc 26820
acagccgctc cagaacctaa ccttccttct gatactatca aacctcgttt cggaggtgag 26880
ctaaggcttc ccccttctga ggagggggtt agcccatacg aagtggtcgg gtatttgatt 26940
ttaggggtgg tcctgggtgg gtgcatagcg gtgctagctc agctgccttg ctgggtagaa 27000
atcaaaatct ttatatgctg ggtcagacat tgtggggagg aactatgaag gggctcttgc 27060
tgattatcct ttccctggtg gggggtgtgc tgtcatgcca cgaacagcca cgatgtaaca 27120
tcaccacagg caatgagagg agtgtcatat gcacagtagt catcaaatgc gagcatgaat 27180
gccctctcaa catcacattc aaaaaccgta ccatggggaa tgcatgggtg ggcgactggg 27240
aaccaggaga tgagcagaac tacacggtca ctgtccatgg tagcgatgga aatcacactt 27300
tcggtttcaa attcattttt gaagtcatgt gtgatatcac actgcatgtg gctagacttc 27360
atggcttgtg gccccctacc aaggaaaaca tggttgggtt ttctttggct tttgtgatca 27420
tggcctgctt tatgtcaggt ctgctggtag gagctctagt gtggttcctg aaacgcaagc 27480
ccaggtatgg aaatgaggag aaggaaaaat tgctataaat tctttttctt ttcacagcac 27540
catgaatact ttgaccagtg tcgtgctgct ctctcttctt gtagctttta gtcaggcagg 27600
aattattaac ttaaatgtat catggggaat gaatctaact ttagtgggac cctcagacct 27660
gccagttaca tggtatgatg gaaagggaat gcagttttgt gatggaaata caattaagaa 27720
cccacaaatc aagcatagct gtaatcaaca gaatctaact ttacttaatg ctgacaagtc 27780
tcatgaaaga acttacctag gttacagaca tgacagtaag ggaaaagtag actataaggt 27840
tacagtcata ccacctcctc cagccactcg caagcctttg tcagagcctc attatgttac 27900
tgtgactatg ggcgataaca taactttagt gggaccctca gacctgccag ttacatggta 27960
tgatggagaa ggaaataaat tctgcgatgg agaaaaagtt gaacatgcag aatttaatca 28020
tacatgtaac atccagaacc tgacactgct ctttgtcaac ttaacgcata atggagcata 28080
cattggttat aacaaagacg gttctgatag agaattatat gaggtgtcag tcaaaacctt 28140
gtttcagaac ggggctggac aaagtaaggt tgaacaaggt aataaaggga aacctaatac 28200
tgctcaaagt ggtggtaaaa aaaccaaaac agaacataga aaccagagtc caaaaagaaa 28260
atcaacaaat aaccttcagc caacacaatt gtatgttagg ccttttacta atgttagttt 28320
aactggacct ccaaatggca aggttacttg gtatgatggc gaacttaatg atccatgtga 28380
acaaaagtac aaactcagaa ctttttgcaa tcagcaaaat ctaactttaa ttaatgtaag 28440
cagcacttat gatggcatct attatggcac tgatgaaaaa gataaggcaa atcgttacag 28500
aataaaagta aatactacaa atcacaaaac tgttaaaatt aagccacata ccagagaacc 28560
tcctgctgta caagaaaaac agtttgaatt acaagatgca gaaactgatg aaaacgaatc 28620
aaaaattccc tcagctactg tggcaatcgt ggtgggagtg attgcgggct ttgtaactct 28680
gatcattgtc ttcatatgct acatctgctg ccgcaagcgt cccaggtcat acaatcatat 28740
ggtagaccca ctactcagct tctcttactg aaactcagtc actctcattt cagaaccatg 28800
aaggctttca cagcttgcgt tctgattagc atagtcacac ttagttcagc tgcaatgatt 28860
aatgttaatg tcactagagg tggtaaaatt acattgaatg ggacttatcc acaaactaca 28920
tggacaagat atcataaaga tggatggaaa aatatctgtg aatggaatgt tactgcatat 28980
aaatgcttca ataatggaag cattactatt actgccactg ccaacattac ttctggcaca 29040
tacaaagctg aaagctataa aaatgaaatc aaaaaactaa cctataaaaa caacaaaacc 29100
acatttgaag attctggaaa ttatgaacat caaaaattat ctttttatat gttgacaata 29160
attgaactgc ctacaactaa ggctcccacc acaaccagta caactattaa gaccactact 29220
cacactacag tgcaaaatac tactttattg attgggtttt tactgagaga gaatgaaagt 29280
actactgaac agacagaggc tacctcaagt gccttcagca gcactgcaaa tttaacttcg 29340
cttgcttgga ctaatgaaac cggagtatca ttgatgcatg gccagcctta ctcaggtttg 29400
gatattcaaa ttacttttct ggttgtctgt gggatcttta ttcttgtggt tcttctgtac 29460
tttgtctgct gcaaagccag agagaaatct aggaggccca tctacaggcc agtgattggg 29520
gaacctcagc cactccaagt ggatggaggc ttaaggaatc ttctcttctc ttttacagta 29580
tggtgatcag ccatgattcc taggttcttc ctatttaaca tcctcttttg tctcttcaac 29640
atctgtgctg ccttcgcggc cgtctcgcac gcctcgcccg actgtctagg gcctttcccc 29700
acctacctcc tctttgccct gctcacctgc acctgcgtct gcagcattgt ctgcgtggtc 29760
atcaccttcc tgcagctcat cgactggtgc tgcgcgcgct ataattatct ccaccacagt 29820
cccgaataca gggacgagaa cgtagccaga atcttaaggc tcatctgacc atgcagactc 29880
tgctcatgct gctatccctc ctatcccctg ccctcgccac ttctgctgac tctaaatgca 29940
aattcgcgga gatatggaat ttcttagatt gctatcagga gaaaattgat atgccctcct 30000
attacttggt gattgtggga atagtcatgg tctgctcctg cactttcttt gccatcatga 30060
tctacccctg ttttgatctc ggctggaact ctgttgaggc attcacatac acactagaaa 30120
gcagttcact agcctccacg ccaccgccca caccgcctcc ccgcagaaat cagttcccac 30180
tgattcagta cttagaagag ccccctcccc ggcccccttc cactgttagc tactttcaca 30240
taaccggcgg cgatgactga ccaccacctg gacctcgaga tggacggcca ggcctccgag 30300
cagcgcatcc tgcaactgcg cgtccgtcag cagcaggagc gggccgccaa ggagctcctc 30360
gatgccatca acatccacca gtgcaagaag ggcatcttct gccttgtcaa acaggcaaag 30420
atcacctacg agctcgtgtc cggcggcaag cagcatcgcc tcacctatga gctgccccag 30480
cagaagcaga agttcacctg catggtgggc gtcaacccca tagtcatcac ccagcagtcg 30540
ggcgagacca acggctgcat ccactgctcc tgcgaaagcc ccgagtgcat atactccctc 30600
ctcaagaccc tttgcggact ccgcgacctc ctccccatga actgatgttg attaaaagca 30660
cgaaaaccaa tcagaccctt cccccatttc cccattccca attactcata aaataaatca 30720
ttggaattaa tcattcaata aaaatcactt acttgaaatc tgaaagtatg tctctggtgt 30780
agttgttcag cagcacctcg ttaccctcct cccagctctg gtattccagt ccccggcggg 30840
cggcgaactt cctccacacc ttgaaaggga tgtcaaattc ctggtccaca attttcattg 30900
tcttccctct cagatgtcaa agaggctccg ggtggaagat gacttcaacc ccgtctaccc 30960
ctatggctac gcgcggaatc agaatatccc cttcctcact cccccctttg tctcctccga 31020
tggattccaa aacttccccc ctggggtcct gtcactcaaa ctggctgacc caatagccat 31080
cgtcaatggg aatgtctcac tcaaagtggg agggggtctc actttgcaag atggaactgg 31140
aaaactaaca gtcaatgctg atccaccttt gcaacttaca aacaacaaat tagggattgc 31200
tttggacgct ccatttgatg ttatagacaa taaactcaca ttgttagcgg gccatggctt 31260
gtctattata acaaaagaaa catcaacact gcctggcttg attaatactc ttgtagtatt 31320
aactggaaag ggtattggaa cagaatcaac agataatggc ggaagcgtat gtgttagagt 31380
tggagaaggt ggcggcttat catttaataa tgatggagac ttggtagcat ttaataaaaa 31440
agaagataag cgcaccctat ggacaactcc agacacatct ccaaattgca agattgatca 31500
agataaggac tctaagttaa ctctggtcct tacaaagtgt ggaagtcaaa tattggctaa 31560
tgtgtcatta attgtcgtag ctggtaagta caaaattatc aataacaata ctcaaccagc 31620
tctcaaagga tttaccatta aattattgtt tgatgaaaat ggagtactta tggaatcttc 31680
aaatcttggt aaatcatatt ggaactttag aaatgaaaat tcaattatgt caacagctta 31740
tgaaaaagct attggattca tgcctaattt ggtagcctat ccaaaaccta ccgctggctc 31800
taaaaaatat gcaagagata tagtttatgg aaacatctac cttggtggaa agccagatca 31860
accagtaacc attaaaacta cctttaatca ggaaactgga tgtgaatatt ctatcacatt 31920
tgattttagt tgggccaaga cttatgtaaa tgttgaattt gaaacaacct cttttacctt 31980
ttcctatatc gcccaagaat gaaagaccaa taaacgtgtt tttcatttca aaattttcat 32040
gtatctttat tgatttttac accagcacgg gtagtcagtc tcccaccacc agcccatttc 32100
acagtgtaca ctgttctctc agcacgggtg gccttaaata gggaaatgtt ctcattagtg 32160
cgggaactgg acttggggtc tataatccac acagtttcct ggcgagccaa acgggggtcg 32220
gtgattgaga tgaagccgtc ctctgaaaag tcatccaagc gagcctcaca gtccaaggtc 32280
acagtctggt ggaatgagaa gaacgcacag attcatactc ggaaaacagg atgggtctgt 32340
gcctctccat cagcgccctc agcagtctct gccgccgggg ctcggtgcgg ctgctgcaga 32400
ttggatcggg atcgcaagtc tctctgacta taatccccac agccttcagc atcagtctcc 32460
tggtgcgtcg ggcacagcac cgcatcctga tctctgccat gttctcacag taagtgcagc 32520
acataatcac catgttattc agcagcccat aattcagggc gctccagcca aagctcatgt 32580
tggggatgat ggaacccacg tgaccatcgt accagatgcg gcagtatatc aggtgcctgc 32640
ccctcataaa cacactgccc atatacatga tctctttggg catgtttctg ttcacaatct 32700
gacggtacca ggggaagcgc tggttgaaca tgcacccgta aatgactctc ctgaaccaca 32760
cggccagcag ggtgcctccc gcccgacact gcagggagcc cggggatgaa cagtggcaat 32820
gcaggatcca gcgctcgtac ccgctcacca tctgagctct caccaagtcc agggtagcag 32880
ggcacaggca cactgacata catcttttta aaatttttat ttcctctggg gtcaggatca 32940
tatcccaggg gactggaaac tcttggagca gggtaaagcc agcagcacat ggtaatccac 33000
ggacagaact tacattatga taatctgcat gatcacaatc gggcaacagg ggatgttgtt 33060
cagtcagtga agccctggtt tcctcatcag atcgtggtaa acgggccctg cgatatggat 33120
gatggcggag cgagctggat tgaatctcgg tttgcattgt agtggattct cttgcgtacc 33180
ttgtcgtact tctgccagca gaaatgggcc cttgaacagc agatacccct cctgcggccg 33240
tcctttcgct gctgccgctc agtcatccaa ctgaagtaca tccattctcg aagattctgg 33300
agaagttcct ctgcatctga tgaaataaaa aacccgtcca tgcgaattcc cctcatcaca 33360
tcagccagga ctctgtaggc catccccatc cagttaatgc tgccttgtct atcattcaga 33420
gggggcggtg gcaggattgg aagaaccatt tttattccaa acggtctcga aggacgataa 33480
agtgcaagtc acgcaggtga cagcgttccc ctccgctgtg ctggtggaaa cagacagcca 33540
ggtcaaaacc cactctattt tcaaggtgct cgaccgtggc ttcgagcagt ggctctacgc 33600
gtacatccag cataagaatc acattaaagg ctggccctcc atcgatttca tcaatcatca 33660
ggttacattc ctgcaccatc cccaggtaat tctcattttt ccagccttga attatctcta 33720
caaattgttg gtgtaagtcc actccgcaca tgtggaaaag ctcccacagt gccccctcca 33780
ctttcataat caggcagacc ttcataatag aaacagatcc tgctgctcca ccacctgcag 33840
cgtgttcaaa acaacaagat tcaataaggt tctgccctcc gccctgagct cgcgcctcaa 33900
tgtcagctgc aaaaagtcac ttaagtcctg ggccactaca gctgacaatt cagagccagg 33960
gctaagcgtg ggactggcaa gcgtaaggga aaactttaat gctccaaagc tagcacccaa 34020
aaactgcatg ctggaataag ctctctttgt gtctccggtg atgccttcca aaatgtgagt 34080
gataaagcgt ggtagttttt ctttaatcat ttgcgtaata gaaaagtcct ctaaataagt 34140
cactaggacc ccagggacca caatgtggta gcttacaccg cgtcgctgaa gcatggttag 34200
tagagatgag agtctgaaaa acagaaagca tgcactaaac taaggtggct atttttactg 34260
aaggaaaaat cactctctcc agcaacaggg tacccactgg gtggcccttg cggacataca 34320
aaaatcggtc cgtgtgatta aaaagcagca cagtaagttc ctgtcttctt ccggcaaaaa 34380
tcacatcgga ctgggttagt atgtccctgg catggtagtc attcaaggcc ataaatctgc 34440
cctgatatcc agtaggaacc agcacactca cttttaggtg aagcaatacc accccatgcg 34500
gaggaatgtg gaaagattca gggcaaaaga aggtatatct attgctagtc ccttcctgga 34560
cgggagcgat ccctccagga ctatctatga aagcatacag agattcagcc atagctcagc 34620
ccgcttacca gtagacagag agcacagcag tacaagcgcc aacagcagcg actgactacc 34680
cactaaccca gctccctatt taaaggcacc ttacactgac gtaatgacca aaggtctaaa 34740
aaccccgcca aaaaaacaca cacgccctgg gtgttttttc gcgaaaacac ttccgcgttc 34800
tcacttcctc gtatcgattt cgtgactcaa cttccgggtt cccacgttac gtcacttctg 34860
cccttacatg taactcagtc gtagggcgcc atgttgccca cgtccaaaat ggtttccatg 34920
tccagccacg cctccgcggc gaccgttagc cgtgcgtcgt gacgtcattt gcatcgtctt 34980
ctctcgtcca atcagcgttg gctccgcccc gaaaccgtta aaattcaaaa gctcatttgc 35040
atattaactt ttgtttactt tgtggggtat attatataga tag 35083
<210> 141
<211> 34794
<212> DNA
<213> 人11型腺病毒（Human adenovirus type 11）
<400> 141
catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60
aaaagtgtgg atcgtgtggt gattggctgt ggggttaacg gctaaaaggg gcggtgcgac 120
cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180
acgcataaaa aggctttttt ctcacggaac tacttagttt tcccacggta tttaacagga 240
aatgaggtag ttttgaccgg atgcaagtga aaattgttga ttttcgcgcg aaaactgaat 300
gaggaagtgt ttttctgaat aatgtggtat ttatggcagg gtggagtatt tgttcagggc 360
caggtagact ttgacccatt acgtggaggt ttcgattacc gtgtttttta cctgaatttc 420
cgcgtaccgt gtcaaagtct tctgttttta cgtaggtgtc agctgatcgc tagggtattt 480
atacctcagg gtttgtgtca agaggccact cttgagtgcc agcgagaaga gttttctcct 540
ctgcgccggc agtttaataa taaaaaaatg agagatttgc gatttctgcc tcaggaaata 600
atctctgctg agactggaaa tgaaatattg gagcttgtgg tgcacgccct gatgggagac 660
gatccggagc cacctgtgca gctttttgag cctcctacgc ttcaggaact gtatgattta 720
gaggtagagg gatcggagga ttctaatgag gaagctgtaa atggcttttt taccgattct 780
atgcttttag ctgctaatga agggttagaa ttagatccgc ctttggacac ttttgatact 840
ccaggggtaa ttgtggaaag cggtacaggt gtaagaaaat tacctgattt gagttccgtg 900
gactgtgatt tgcactgcta tgaagacggg tttcctccga gtgatgagga ggaccatgaa 960
aaggagcagt ccatgcagac tgcagcgggt gagggagtga aggctgccaa tgttggtttt 1020
cagttggatt gcccggagct tcctggacat ggctgtaagt cttgtgaatt tcacaggaaa 1080
aatactggag taaaggaact gttatgttcg ctttgttata tgagaacgca ctgccacttt 1140
atttacagta agtgtgttta agttaaaatt taaaggaata tgctgttttt cacatgtata 1200
ttgagtgtga gttttgtgct tcttattata ggtcctgtgt ctgatgctga tgaatcacca 1260
tctcctgatt ctactacctc acctcctgag attcaagcac ctgttcctgt ggacgtgcgc 1320
aagcccattc ctgtgaagct taagcctggg aaacgtccag cagtggaaaa acttgaggac 1380
ttgttacagg gtggggacgg acctttggac ttgagtacac ggaaacgtcc aagacaataa 1440
gtgttccata tccgtgttta cttaaggtga cgtcaatatt tgtgtgacag tgcaatgtaa 1500
taaaaatatg ttaactgttc actggttttt attgcttttt gggcggggac tcaggtatat 1560
aagtagaagc agacctgtgt ggttagctca taggagctgg ctttcatcca tggaggtttg 1620
ggccattttg gaagacctta ggaagactag gcaactgtta gagaacgctt cggacggagt 1680
ctccggtttt tggagattct ggttcgctag tgaattagct agggtagttt ttaggataaa 1740
acaggactat aaccaagaat ttgaaaagtt gttggtagat tgcccaggac tttttgaagc 1800
tcttaatttg ggccatcagg ttcactttaa agaaaaagtt ttatcagttt tagacttttc 1860
aaccccaggt agaactgctg ctgctgtggc ttttcttact tttatattag ataaatggat 1920
cccgcagact catttcagca ggggatacgt tttggatttc atagccacag cattgtggag 1980
aacatggaag gttcgcaaga tgaggacaat cttaggttac tggccagtgc agcctttggg 2040
tgtagcggga atcctgaggc atccaccggt catgccagcg gttctggagg aggaacagca 2100
agaggacaac ccgagagccg gcctggaccc tccagtggag gaggcggagt agctgacttg 2160
tctcctgaac tgcaacgggt gcttactgga tctacgtcca ctggacggga taggggcgtt 2220
aagagggaga gggcatctag tggtactgat gctagatctg agttggcttt aagtttaatg 2280
agtcgcagac gtcctgaaac catttggtgg catgaggttc agaaagaggg aagggatgaa 2340
gtttctgtat tgcaggagaa atattcactg gaacaggtga aaacatgttg gttggagcct 2400
gaggatgatt gggaggtggc cattaaaaat tatgccaaga tagctttgag gcctgataaa 2460
cagtataaga ttactagacg gattaatatc cggaatgctt gttacatatc tggaaatggg 2520
gctgaggtgg taatagatac tcaagacaag gcagttatta gatgctgcat gatggatatg 2580
tggcctgggg tagtcggtat ggaagcagta acttttgtaa atgttaagtt taggggagat 2640
ggttataatg gaatagtgtt tatggccaat accaaactta tattgcatgg ttgtagcttt 2700
tttggtttca acaatacctg tgtagatgcc tggggacagg ttagtgtacg gggatgtagt 2760
ttctatgcgt gttggattgc cacagctggc agaaccaaga gtcaattgtc tctgaagaaa 2820
tgcatatttc aaagatgtaa cctgggcatt ctgaatgaag gcgaagcaag ggtccgccac 2880
tgcgcttcta cagatactgg atgttttatt ttgattaagg gaaatgccag cgtaaagcat 2940
aacatgattt gcggtgcttc cgatgagagg ccttatcaaa tgctcacttg tgctggtggg 3000
cattgtaata tgctggctac tgtgcatatt gtttcccatc aacgcaaaaa atggcctgtt 3060
tttgatcaca atgtgatgac gaagtgtacc atgcatgcag gtgggcgtag aggaatgttt 3120
atgccttacc agtgtaacat gaatcatgtg aaagtgttgt tggaaccaga tgccttttcc 3180
agaatgagcc taacaggaat ttttgacatg aacatgcaaa tctggaagat cctgaggtat 3240
gatgatacga gatcgagggt acgcgcatgc gaatgcggag gcaagcatgc caggttccag 3300
ccggtgtgtg tagatgtgac tgaagatctc agaccggatc atttggttat tgcccgcact 3360
ggagcagagt tcggatccag tggagaagaa actgactaag gtgagtattg ggaaaacttt 3420
ggggtgggat tttcagatgg acagattgag taaaaatttg ttttttctgt cttgcagctg 3480
tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540
tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600
tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660
cagctgcagc tgccgccgcc gcttctgttg ccgctaacac tgtgcttgga atgggttact 3720
atggaagcat catggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780
agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttctc 3840
agcaggtggt cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900
aaaaaaatcc cagaatcaat gaataaataa acaagcttgt tgttgattta aaatcaagtg 3960
tttttatttc atttttcgcg cacggtatgc cctagaccac cgatctctat cattgagaac 4020
tcggtggatt ttttccagga tcctatagag gtgggattga atgtttagat acatgggcat 4080
taggccgtct ttggggtgga gatagctcca ttgaagggat tcatgctccg gggtagtgtt 4140
gtaaatcacc cagtcataac aaggtcgcag tgcatggtgt tgcacaatat cttttagaag 4200
taggctgatt gccacagata agcccttggt gtaggtgttt acaaaccggt tgagctggga 4260
tgggtgcatt cggggtgaaa ttatgtgcat tttggattgg atttttaagt tggcaatatt 4320
gccgccaaga tcccgtcttg ggttcatgtt atgaaggacc accaagacgg tgtatccggt 4380
acatttagga aatttatcgt gcagcttgga tggaaaagcg tggaaaaatt tggagacacc 4440
cttgtgtcct ccaagatttt ccatgcactc atccatgata atagcaatgg ggccgtgggc 4500
agcggcgcgg gcaaacacgt tccgtgggtc tgacacatca tagttatgtt cctgagttaa 4560
atcatcataa gccattttaa tgaatttggg gcggagagta ccagattggg gtatgaatgt 4620
tccttcgggc cccggagcat agttcccctc acagatttgc atttcccaag ctttcagttc 4680
cgagggtgga atcatgtcca cctggggggc tatgaaaaac accgtttctg gggcgggggt 4740
gattaattgt gatgatagca aatttctgag caattgagat ttgccacatc cggtggggcc 4800
ataaatgatt ccgattacgg gttgcaggtg gtagtttagg gaacggcaac tgccgtcttc 4860
tcgaagcaag ggggccacct cgttcatcat ttcccttaca tgcatatttt cccgcaccaa 4920
atccattagg aggcgctctc ctcctagtga tagaagttct tgtagtgagg aaaagttttt 4980
cagcggtttc agaccgtcag ccatgggcat tttggagaga gtttgctgca aaagttctag 5040
tctgttccac agttcagtga tgtgttctat ggcatctcga tccagcagac ctcctcgttt 5100
cgcgggtttg gacggctcct ggaatagggt atgagacgat gggcgtccag cgctgccagg 5160
gttcggtcct tccagggtct cagtgttcga gtcagggttg tttccgtcac agtgaagggg 5220
tgtgcgcctg cttgggcgct tgccagggtg cgcttcagac tcatcctgct ggtcgaaaac 5280
ttctgtcgct tggcgccctg tatgtcggcc aagtagcagt ttaccatgag ttcgtagttg 5340
agcgcctcgg ctgcgtggcc tttggcgcgg agcttacctt tggaagtttt cttgcatacc 5400
gggcagtata ggcatttcag cgcatacaac ttgggcgcaa ggaaaacgga ttctggggag 5460
tatgcatctg cgccgcagga ggcgcaaaca gtttcacatt ccaccagcca ggttaaatcc 5520
ggttcattgg ggtcaaaaac aagttttccg ccatattttt tgatgcgttt cttacctttg 5580
gtctccatga gttcgtgtcc tcgttgagtg acaaacaggc tgtccgtgtc cccgtagact 5640
gattttacag gcctcttctc cagtggagtg cctcggtctt cttcgtacag gaactctgac 5700
cactctgata caaaggcgcg cgtccaggcc agcacaaagg aggctatgtg ggaggggtag 5760
cgatcgttgt caaccagggg gtccaccttt tccaaagtat gcaaacacat gtcaccctct 5820
tcaacatcca ggaatgtgat tggcttgtag gtgtatttca cgtgacctgg ggtccccgct 5880
gggggggtat aaaagggggc ggttctttgc tcttcctcac tgtcttccgg atcgctgtcc 5940
aggaacgtca gctgttgggg taggtattcc ctctcgaagg cgggcatgac ctctgcactc 6000
aggttgtcag tttctaagaa cgaggaggat ttgatattga cagtgccggt tgagatgcct 6060
ttcatgaggt tttcgtccat ttggtcagaa aacacaattt ttttattgtc aagtttggtg 6120
gcaaatgatc catacagggc gttggataaa agtttggcaa tggatcgcat ggtttggttc 6180
ttttccttgt ccgcgcgctc tttggcggcg atgttgagtt ggacatactc gcgtgccagg 6240
cacttccatt cggggaagat agttgttaat tcatctggca cgattctcac ttgccaccct 6300
cgattatgca aggtaattaa atccacactg gtggccacct cgcctcgaag gggttcattg 6360
gtccaacaga gcctacctcc tttcctagaa cagaaagggg gaagtgggtc tagcataagt 6420
tcatcgggag ggtctgcatc catggtaaag attcccggaa gtaaatcctt atcaaaatag 6480
ctgatgggag tggggtcatc taaggccatt tgccattctc gagctgccag tgcgcgctca 6540
tatgggttaa ggggactgcc ccatggcatg ggatgggtga gtgcagaggc atacatgcca 6600
cagatgtcat agacgtagat gggatcctca aagatgccta tgtaggttgg atagcatcgc 6660
ccccctctga tacttgctcg cacatagtca tatagttcat gtgatggcgc tagcagcccc 6720
ggacccaagt tggtgcgatt gggtttttct gttctgtaga cgatctggcg aaagatggcg 6780
tgagaattgg aagagatggt gggtctttga aaaatgttga aatgggcatg aggtagacct 6840
acagagtctc tgacaaagtg ggcataagat tcttgaagct tggttaccag ttcggcggtg 6900
acaagtacgt ctagggcgca gtagtcaagt gtttcttgaa tgatgtcata acctggttgg 6960
tttttctttt cccacagttc gcggttgaga aggtattctt cgcgatcctt ccagtactct 7020
tctagcggaa acccgtcttt gtctgcacgg taagatccta gcatgtagaa ctgattaact 7080
gccttgtaag ggcagcagcc cttctctacg ggtagagagt atgcttgagc agcttttcgt 7140
agcgaagcgt gagtaagggc aaaggtgtct ctgaccatga ctttgagaaa ttggtatttg 7200
aagtcgatgt cgtcacaggc tccctgttcc cagagttgga agtctacccg tttcttgtag 7260
gcggggttgg gcaaagcgaa agtaacatca ttgaagagaa tcttaccggc tctgggcata 7320
aaattgcgag tgatgcgaaa aggctgtggt acttccgctc gattgttgat cacctgggca 7380
gctaggacga tctcgtcgaa accgttgatg ttgtgtccta cgatgtataa ttctatgaaa 7440
cgcggcgtgc ctctgacgtg aggtagctta ctgagctcat caaaggttag gtctgtgggg 7500
tcagataagg cgtagtgttc gagagcccat tcgtgcaggt gaggatttgc atgtaggaat 7560
gatgaccaaa gatctaccgc cagtgctgtt tgtaactggt cccgatactg acgaaaatgc 7620
cggccaattg ccattttttc tggagtgaca cagtagaagg ttctggggtc ttgttgccat 7680
cgatcccact tgagtttaat ggctagatcg tgggccatgt tgacgagacg ctcttctcct 7740
gagagtttca tgaccagcat gaaaggaact agttgtttgc caaaggatcc catccaggtg 7800
taagtttcca catcgtaggt caggaagagt ctttctgtgc gaggatgaga gccgatcggg 7860
aagaactgga tttcctgcca ccagttggag gattggctgt tgatgtgatg gaagtagaag 7920
tttctgcggc gcgccgagca ttcgtgtttg tgcttgtaca gacggccgca gtagtcgcag 7980
cgttgcacgg gttgtatctc gtgaatgagt tgtacctggc ttcccttgac gagaaatttc 8040
agtgggaagc cgaggcctgg cgattgtatc tcgtgctctt ctatattcgc tgtatcggcc 8100
tgttcatctt ctgtttcgat ggtggtcatg ctgacgagcc cccgcgggag gcaagtccag 8160
acctcggcgc gggaggggcg gagctgaagg acgagagcgc gcaggctgga gctgtccaga 8220
gtcctgagac gctgcggact caggttagta ggtagggaca gaagattaac ttgcatgatc 8280
ttttccaggg cgtgcgggag gttcagatgg tacttgattt ccacaggttc gtttgtagag 8340
acgtcaatgg cttgcagggt tccgtgtcct ttgggcgcca ctaccgtacc tttgtttttt 8400
cttttgatcg gtggtggctc tcttgcttct tgcatgctca gaagcggtga cggggacgcg 8460
cgccgggcgg cagcggttgt tccggacccg agggcatggc tggtagtggc acgtcggcgc 8520
cgcgcacggg caggttctgg tactgcgctc tgagaagact tgcgtgcgcc accacgcgtc 8580
gattgacgtc ttgtatctga cgtctctggg tgaaagctac cggccccgtg agcttgaacc 8640
tgaaagagag ttcaacagaa tcaatttcgg tatcgttaac ggcagcttgt ctcagtattt 8700
cttgtacgtc accagagttg tcctggtagg cgatctccgc catgaactgc tcgatttctt 8760
cctcctgaag atctccgcga cccgctcttt cgacggtggc cgcgaggtca ttggagatac 8820
ggcccatgag ttgggagaat gcattcatgc ccgcctcgtt ccagacgcgg ctgtaaacca 8880
cggccccctc ggagtctctt gcgcgcatca ccacctgagc gaggttaagc tccacgtgtc 8940
tggtgaagac cgcatagttg cataggcgct gaaaaaggta gttgagtgtg gtggcaatgt 9000
gttcggcgac gaagaaatac atgatccatc gtctcagcgg catttcgcta acatcgccca 9060
gagcttccaa gcgctccatg gcctcgtaga agtccacggc aaaattaaaa aactgggagt 9120
ttcgcgcgga cacggtcaat tcctcctcga gaagacggat gagttcggct atggtggccc 9180
gtacttcgcg ttcgaaggct cccgggatct cttcttcctc ttctatctct tcttccacta 9240
acatctcttc ttcgtcttca ggcgggggcg gagggggcac gcggcgacgt cgacggcgca 9300
cgggcaaacg gtcgatgaat cgttcaatga cctctccgcg gcggcggcgc atggtttcag 9360
tgacggcgcg gccgttctcg cgcggtcgca gagtaaaaac accgccgcgc atctccttaa 9420
agtggtgact gggaggttct ccgtttggga gggagagggc gctgattata cattttatta 9480
attggcccgt agggactgca cgcagagatc tgatcgtgtc aagatccacg ggatctgaaa 9540
acctttcgac gaaagcgtct aaccagtcac agtcacaagg taggctgagt acggcttctt 9600
gtgggcgggg gtggttatgt gttcggtctg ggtcttctgt ttcttcttca tctcgggaag 9660
gtgagacgat gctgctggtg atgaaattaa agtaggcagt tctaagacgg cggatggtgg 9720
cgaggagcac caggtctttg ggtccggctt gctggatacg caggcgattg gccattcccc 9780
aagcattatc ctgacatcta gcaagatctt tgtagtagtc ttgcatgagc cgttctacgg 9840
gcacttcttc ctcacccgtt ctgccatgca tacgtgtgag tccaaatccg cgcattggtt 9900
gtaccagtgc caagtcagct acgactcttt cggcgaggat ggcttgctgt acttgggtaa 9960
gggtggcttg aaagtcatca aaatccacaa agcggtggta agctcctgta ttaatggtgt 10020
aagcacagtt ggccatgact gaccagttaa ctgtctggtg accagggcgc acgagctcgg 10080
tgtatttaag gcgcgaatag gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca 10140
gatactggta ccctataaga aaatgcggcg gtggttggcg gtagagaggc catcgttctg 10200
tagctggagc gccaggggcg aggtcttcca acataaggcg gtgatagccg tagatgtacc 10260
tggacatcca ggtgattcct gcggcggtag tagaagcccg aggaaactcg cgtacgcggt 10320
tccaaatgtt gcgtagcggc atgaagtagt tcattgtagg cacggtttga ccagtgaggc 10380
gcgcgcagtc attgatgctc tatagacacg gagaaaatga aagcgttcag cgactcgact 10440
ccgtagcctg gaggaacgtg aacgggttgg gtcgcggtgt accccggttc gagacttgta 10500
ctcgagccgg ccggagccgc ggctaacgtg gtattggcac tcccgtctcg acccagccta 10560
caaaaatcca ggatacggaa tcgagtcgtt ttgctggttt ccgaatggca gggaagtgag 10620
tcctattttt tttttttgcc gctcagatgc atcccgtgct gcgacagatg cgcccccaac 10680
aacagccccc ctcgcagcag cagcagcagc aatcacaaaa ggctgtccct gcaactactg 10740
caactgccgc cgtgagcggt gcgggacagc ccgcctatga tctggacttg gaagagggcg 10800
aaggactggc acgtctaggt gcgccttcac ccgagcggca tccgcgagtt caactgaaaa 10860
aagattctcg cgaggcgtat gtgccccaac agaacctatt tagagacaga agcggcgagg 10920
agccggagga gatgcgagct tcccgcttta acgcgggtcg tgagctgcgt cacggtttgg 10980
accgaagacg agtgttgcgg gacgaggatt tcgaagttga tgaaatgaca gggatcagtc 11040
ctgccagggc acacgtggct gcagccaacc ttgtatcggc ttacgagcag acagtaaagg 11100
aagagcgtaa cttccaaaag tcttttaata atcatgtgcg aaccctgatt gcccgcgaag 11160
aagttaccct tggtttgatg catttgtggg atttgatgga agctatcatt cagaacccta 11220
ctagcaaacc tctgaccgcc cagctgtttc tggtggtgca acacagcaga gacaatgagg 11280
ctttcagaga ggcgctgctg aacatcaccg aacccgaggg gagatggttg tatgatctta 11340
tcaacattct acagagtatc atagtgcagg agcggagcct gggcctggcc gagaaggtgg 11400
ctgccatcaa ttactcggtt ttgagcttgg gaaaatatta cgctcgcaaa atctacaaga 11460
ctccatacgt tcccatagac aaggaggtga agatagatgg gttctacatg cgcatgacgc 11520
tcaaggtctt gaccctgagc gatgatcttg gggtgtatcg caatgacaga atgcatcgcg 11580
cggttagcgc cagcaggagg cgcgagttaa gcgacaggga actgatgcac agtttgcaaa 11640
gagctctgac tggagctgga accgagggtg agaattactt cgacatggga gctgacttgc 11700
agtggcagcc tagtcgcagg gctctgagcg ccgcgacggc aggatgtgag cttccttaca 11760
tagaagaggc ggatgaaggc gaggaggaag agggcgagta cttggaagac tgatggcaca 11820
acccgtgttt tttgctagat ggaacagcaa gcaccggatc ccgcaatgcg ggcggcgctg 11880
cagagccagc cgtccggcat taactcctcg gacgattgga cccaggccat gcaacgtatc 11940
atggcgttga cgactcgcaa ccccgaagcc tttagacagc aaccccaggc caaccgtcta 12000
tcggccatca tggaagctgt agtgccttcc cgctctaatc ccactcatga gaaggtcctg 12060
gccatcgtga acgcgttggt ggagaacaaa gctattcgtc cagatgaggc cggactggta 12120
tacaacgctc tcttagaacg cgtggctcgc tacaacagta gcaatgtgca aaccaatttg 12180
gaccgtatga taacagatgt acgcgaagcc gtgtctcagc gcgaaaggtt ccagcgtgat 12240
gccaacctgg gttcgctggt ggcgttaaat gctttcttga gtactcagcc tgctaatgtg 12300
ccgcgtggtc aacaggatta tactaacttt ttaagcgctt tgagactgat ggtatcagaa 12360
gtacctcaga gcgaagtgta tcagtccggt cctgattact tctttcagac tagcagacag 12420
ggcttgcaga cggtaaatct gagccaagct tttaaaaacc ttaaaggttt gtggggagtg 12480
catgccccgg taggagaaag agcaaccgtg tctagcttgt taactccgaa ctcccgccta 12540
ttattactgt tggtagctcc tttcaccgac agcggtagca tcgaccgtaa ttcctatttg 12600
ggttacctac taaacctgta tcgcgaagcc atagggcaaa gtcaggtgga cgagcagacc 12660
tatcaagaaa ttacccaagt cagtcgcgct ttgggacagg aagacactgg cagtttggaa 12720
gccactctga acttcttgct taccaatcgg tctcaaaaga tccctcctca atatgctctt 12780
actgcggagg aggagaggat ccttagatat gtgcagcaga gcgtgggatt gtttctgatg 12840
caagaggggg caactccgac tgcagcactg gacatgacag cgcgaaatat ggagcccagc 12900
atgtatgcca gtaaccgacc tttcattaac aaactgctgg actacttgca cagagctgcc 12960
gctatgaact ctgattattt caccaatgcc atcttaaacc cgcactggct gcccccacct 13020
ggtttctaca cgggcgaata tgacatgccc gaccctaatg acggatttct gtgggacgac 13080
gtggacagcg atgttttttc acctctttct gatcatcgca cgtggaaaaa ggaaggcggc 13140
gatagaatgc attcttctgc atcgctgtcc ggggtcatgg gtgctaccgc ggctgagccc 13200
gagtctgcaa gtccttttcc tagtctaccc ttttctctac acagtgtacg tagcagcgaa 13260
gtgggtagaa taagtcgccc gagtttaatg ggcgaagagg agtatctaaa cgattccttg 13320
ctcagaccgg caagagaaaa aaatttccca aacaatggaa tagaaagttt ggtggataaa 13380
atgagtagat ggaagactta tgctcaggat cacagagacg agcctgggat catggggatt 13440
acaagtagag cgagccgtag acgccagcgc catgacagac agaggggtct tgtgtgggac 13500
gatgaggatt cggccgatga tagcagcgtg ctggacttgg gtgggagagg aaggggcaac 13560
ccgtttgctc atttgcgccc tcgcttgggt ggtatgttgt aaaaaaaaat aaaaaaaaaa 13620
ctcaccaagg ccatggcgac gagcgtacgt tcgttcttct ttattatctg tgtctagtat 13680
aatgaggcga gtcgtgctag gcggagcggt ggtgtatccg gagggtcctc ctccttcgta 13740
cgagagcgtg atgcagcagc agcaggcgac ggcggtgatg caatccccac tggaggctcc 13800
ctttgtgcct ccgcgatacc tggcacctac ggagggcaga aacagcattc gttattcgga 13860
actggcacct cagtacgata ccaccaggtt gtatctggtg gacaacaagt cggcggacat 13920
tgcttctctg aactatcaga atgaccacag caacttcttg accacggtgg tgcaaaacaa 13980
tgactttacc cctacggaag ccagcaccca gaccattaac tttgatgaac gatcgcggtg 14040
gggcggtcag ctaaagacca tcatgcatac taacatgcca aacgtgaacg agtatatgtt 14100
tagtaacaag ttcaaagcgc gtgtgatggt gtccagaaaa cctcccgacg gtgctgcagt 14160
tggggatact tatgatcaca agcaggatat tttgaaatat gagtggttcg agtttacttt 14220
gccagaaggc aacttttcag ttactatgac tattgatttg atgaacaatg ccatcataga 14280
taattacttg aaagtgggta gacagaatgg agtgcttgaa agtgacattg gtgttaagtt 14340
cgacaccagg aacttcaagc tgggatggga tcccgaaacc aagttgatca tgcctggagt 14400
gtatacgtat gaagccttcc atcctgacat tgtcttactg cctggctgcg gagtggattt 14460
taccgagagt cgtttgagca accttcttgg tatcagaaaa aaacagccat ttcaagaggg 14520
ttttaagatt ttgtatgaag atttagaagg tggtaatatt ccggccctct tggatgtaga 14580
tgcctatgag aacagtaaga aagaacaaaa agccaaaata gaagctgcta cagctgctgc 14640
agaagctaag gcaaacatag ttgccagcga ctctacaagg gttgctaacg ctggagaggt 14700
cagaggagac aattttgcgc caacacctgt tccgactgca gaatcattat tggccgatgt 14760
gtctgaagga acggacgtga aactcactat tcaacctgta gaaaaagata gtaagaatag 14820
aagctataat gtgttggaag acaaaatcaa cacagcctat cgcagttggt atctttcgta 14880
caattatggc gatcccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt 14940
cacctgcgga gcagagcagg tctactggtc gcttccagac atgatgaagg atcctgtcac 15000
tttccgctcc actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt 15060
cttctcaaag agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac 15120
ctcgcttacg cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc 15180
gcccaccatt accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc 15240
gttgcgcagc agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac 15300
ctgtccctac gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac 15360
tttctaaaaa aaaaaaaaat gtccattctt atctcgccca gtaataacac cggttggggt 15420
ctgcgcgctc caagcaagat gtacggaggc gcacgcaaac gttctaccca acatcctgtc 15480
cgtgttcgcg gacattttcg cgctccatgg ggcgccctca agggccgcac tcgcgttcga 15540
accaccgtcg atgatgtaat cgatcaggtg gttgccgacg cccgtaatta tactcctact 15600
gcgcctacat ctactgtgga tgcagttatt gacagtgtag tggctgacgc tcgcaactat 15660
gctcgacgta agagccggcg aaggcgcatt gccagacgcc accgagctac cactgccatg 15720
cgagccgcaa gagctctgct acgaagagct agacgcgtgg ggcgaagagc catgcttagg 15780
gcggccagac gtgcagcttc gggcgccagc gccggcaggt cccgcaggca agcagccgct 15840
gtcgcagcgg cgactattgc cgacatggcc caatcgcgaa gaggcaatgt atactgggtg 15900
cgtgacgctg ccaccggtca acgtgtaccc gtgcgcaccc gtccccctcg cacttagaag 15960
atactgagca gtctccgatg ttgtgtccca gcggcgagga tgtccaagcg caaatacaag 16020
gaagaaatgc tgcaggttat cgcacctgaa gtctacggcc aaccgttgaa ggatgaaaaa 16080
aaaccccgca aaatcaagcg ggttaaaaag gacaaaaaag aagaggaaga tggcgatgat 16140
gggctggcgg agtttgtgcg cgagtttgcc ccacggcgac gcgtgcaatg gcgtgggcgc 16200
aaagttcgac atgtgttgag acctggaact tcggtggtct ttacacccgg cgagcgttca 16260
agcgctactt ttaagcgttc ctatgatgag gtgtacgggg atgatgatat tcttgagcag 16320
gcggctgacc gattaggcga gtttgcttat ggcaagcgta gtagaataac ttccaaggat 16380
gagacagtgt cgataccctt ggatcatgga aatcccaccc ctagtcttaa accggtcact 16440
ttgcagcaag tgttacccgt aactccgcga acaggtgtta aacgcgaagg tgaagatttg 16500
tatcccacta tgcaactgat ggtacccaaa cgccagaagt tggaggacgt tttggagaaa 16560
gtaaaagtgg atccagatat tcaacctgag gttaaagtga gacccattaa gcaggtagcg 16620
cctggtctgg gggtacaaac tgtagacatt aagattccca ctgaaagtat ggaagtgcaa 16680
actgaacccg caaagcctac tgccacctcc actgaagtgc aaacggatcc atggatgccc 16740
atgcctatta caactgacgc cgccggtccc actcgaagat cccgacgaaa gtacggtcca 16800
gcaagtctgt tgatgcccaa ttatgttgta cacccatcta ttattcctac tcctggttac 16860
cgaggcactc gctactatcg cagccgaaac agtacctccc gccgtcgccg caagacacct 16920
gcaaatcgca gtcgtcgccg tagacgcaca agcaaaccga ctcccggcgc cctggtgcgg 16980
caagtgtacc gcaatggtag tgcggaacct ttgacactgc cgcgtgcgcg ttaccatccg 17040
agtatcatca cttaatcaat gttgccgctg cctccttgca gatatggccc tcacttgtcg 17100
ccttcgcgtt cccatcactg gttaccgagg aagaaactcg cgccgtagaa gagggatgtt 17160
gggacgcgga atgcgacgct acaggcgacg gcgtgctatc cgcaagcaat tgcggggtgg 17220
ttttttacca gccttaattc caattatcgc tgctgcaatt ggcgcgatac caggcatagc 17280
ttccgtggcg gttcaggcct cgcaacgaca ttgacattgg aaaaaaacgt ataaataaaa 17340
aaaaaaaaat acaatggact ctgacactcc tggtcctgtg actatgtttt cttagagatg 17400
gaagacatca atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc 17460
tggagcgaca tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg 17520
agcgggctta aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc 17580
agtacaggac aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc 17640
gatgggatag cttccggcat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa 17700
aagataaaca gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa 17760
gaaattcctc cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg 17820
ctggtgacgc gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc 17880
accactagac cgatagcccc aatggccacc ggggtgatga aaccttctca gttgcatcga 17940
cccgtcacct tggatttgcc ccctccccct gctgctactg ctgtacccgc ttctaagcct 18000
gtcgctgccc cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca 18060
aatgcgcact ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa 18120
cgccgtcgct gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg 18180
tgtcattaca cgccgtcaca gcagcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg 18240
agttactttc aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc 18300
cggacaggat gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga 18360
cacctacttc aatctgggaa ataagtttag aaatcccacc gtagcgccga cccacgatgt 18420
gaccaccgac cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa 18480
tacatactct tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat 18540
ggccagcacg ttctttgaca ttaggggtgt gttggacaga ggtcccagtt tcaaacccta 18600
ttctggtacg gcttacaact ccctggctcc taaaggcgct ccaaatacat ctcagtggat 18660
tgcagaaggt gtaaaaaata caactggtga ggaacacgta acagaagagg aaaccaatac 18720
tactacttac acttttggca atgctcctgt aaaagctgaa gctgaaatta caaaagaagg 18780
actcccagta ggtttggaag tttcagatga agaaagtaaa ccgatttatg ctgataaaac 18840
atatcagcca gaacctcagc tgggagatga aacttggact gaccttgatg gaaaaaccga 18900
aaagtatgga ggcagggctc tcaaacccga tactaagatg aaaccatgct acgggtcctt 18960
tgccaaacct actaatgtga aaggcggtca ggcaaaacaa aaaacaacgg agcagccaaa 19020
tcagaaagtc gaatatgata tcgacatgga gttttttgat gcggcatcgc agaaaacaaa 19080
cttaagtcct aaaattgtca tgtatgcaga aaatgtaaat ttggaaactc cagacactca 19140
tgtagtgtac aaacctggaa cagaagacac aagttccgaa gctaatttgg gacaacaatc 19200
tatgcccaac agacccaact acattggctt cagagataac tttattggac ttatgtacta 19260
taacagtact ggtaacatgg gggtgctggc tggtcaagcg tctcagttaa atgcagtggt 19320
tgacttgcag gacagaaaca cagaactttc ttaccaactc ttgcttgact ctctgggcga 19380
cagaaccaga tactttagca tgtggaatca ggctgtggac agttatgatc ctgatgtacg 19440
tgttattgaa aatcatggtg tggaagatga acttcccaac tactgttttc cactggacgg 19500
cataggtgtt ccaacaacca gttacaaatc aatagttcca aatggagaca atgcgcctaa 19560
ttggaaggaa cctgaagtaa atggaacaag tgagatcgga cagggtaatt tgtttgccat 19620
ggaaattaac cttcaagcca atctatggcg aagtttcctt tattccaatg tggctctata 19680
tctcccagac tcgtacaaat acaccccgtc caatgtcact cttccagaaa acaaaaacac 19740
ctacgactac atgaacgggc gggtggtgcc gccatctcta gtagacacct atgtgaacat 19800
tggtgccagg tggtctctgg atgccatgga caatgtcaac ccattcaacc accaccgtaa 19860
cgctggcttg cgttaccgat ccatgcttct gggtaacgga cgttatgtgc ctttccacat 19920
acaagtgcct caaaaattct tcgctgttaa aaacctgctg cttctcccag gctcctacac 19980
ttatgagtgg aactttagga aggatgtgaa catggttcta cagagttccc tcggtaacga 20040
cctgcgggta gatggcgcca gcatcagttt cacgagcatc aacctctatg ctactttttt 20100
ccccatggct cacaacaccg cttccaccct tgaagccatg ctgcggaatg acaccaatga 20160
tcagtcattc aacgactacc tatctgcagc taacatgctc taccccattc ctgccaatgc 20220
aaccaatatt cccatttcca ttccttctcg caactgggcg gctttcagag gctggtcatt 20280
taccagactg aaaaccaaag aaactccctc tttggggtct ggatttgacc cctactttgt 20340
ctattctggt tctattccct acctggatgg taccttctac ctgaaccaca cttttaagaa 20400
ggtttccatc atgtttgact cttcagtgag ctggcctgga aatgacaggt tactatctcc 20460
taacgaattt gaaataaagc gcactgtgga tggcgaaggc tacaacgtag cccaatgcaa 20520
catgaccaaa gactggttct tggtacagat gctcgccaac tacaacatcg gctatcaggg 20580
cttctacatt ccagaaggat acaaagatcg catgtattca tttttcagaa acttccagcc 20640
catgagcagg caggtggttg atgaggtcaa ttacaaagac ttcaaggccg tcgccatacc 20700
ctaccaacac aacaactctg gctttgtggg ttacatggct ccgaccatgc gccaaggtca 20760
accctatccc gctaactatc cctatccact cattggaaca actgccgtaa atagtgttac 20820
gcagaaaaag ttcttgtgtg acagaaccat gtggcgcata ccgttctcga gcaacttcat 20880
gtctatgggg gcccttacag acttgggaca gaatatgctc tatgccaact cagctcatgc 20940
tctggacatg acctttgagg tggatcccat ggatgagccc accctgcttt atcttctctt 21000
cgaagttttc gacgtggtca gagtgcatca gccacaccgc ggcatcatcg aggcagtcta 21060
cctgcgtaca ccgttctcgg ccggtaacgc taccacgtaa gaagcttctt gcttcttgca 21120
aatagcagct gcaaccatgg cctgcggatc ccaaaacggc tccagcgagc aagagctcag 21180
agccattgtc caagacctgg gttgcggacc ctattttttg ggaacctacg ataagcgctt 21240
cccggggttc atggcccccg ataagctcgc ctgtgccatt gtaaatacgg ccggacgtga 21300
gacgggggga gagcactggt tggctttcgg ttggaaccca cgttctaaca cctgctacct 21360
ttttgatcct tttggattct cggatgatcg tctcaaacag atttaccagt ttgaatatga 21420
gggtctcctg cgccgcagcg ctcttgctac caaggaccgc tgtattacgc tggaaaaatc 21480
tacccagacc gtgcagggtc cccgttctgc cgcctgcgga cttttctgct gcatgttcct 21540
tcacgccttt gtgcactggc ctgaccgtcc catggacgga aaccccacca tgaaattgct 21600
aactggagtg ccaaacaaca tgcttcattc tcctaaagtc cagcccaccc tgtgtgacaa 21660
tcaaaaagca ctctaccatt ttcttaatac ccattcgcct tattttcgct cccatcgtac 21720
acacatcgaa agggccactg cgttcgaccg tatggatgtt caataatgac tcatgtaaac 21780
aacgtgttca ataaacatca ctttattttt ttacatgtat caaggctctg cattacttat 21840
ttatttacaa gtcgaatggg ttctgacgag aatcagaatg acccgcaggc agtgatacgt 21900
tgcggaactg atacttgggt tgccacttga attcgggaat caccaacttg ggaaccggta 21960
tatcgggcag gatgtcactc cacagctttc tggtcagctg caaagctcca agcaggtcag 22020
gagccgaaat cttgaaatca caattaggac cagtgctttg agcgcgagag ttgcggtaca 22080
ccggattgca gcactgaaac accatcagcg acggatgtct cacgcttgcc agcacggtgg 22140
gatctgcaat catgcccaca tccagatctt cagcattggc aatgctgaac ggggtcatct 22200
tgcaggtctg cctacccatg gcgggcaccc aattaggctt gtggttgcaa tcgcagtgca 22260
gggggatcag tatcatcttg gcctgatcct gtctgattcc tggatacacg gctctcatga 22320
aagcatcata ttgcttgaaa gcctgctggg ctttactacc ctcggtataa aacatcccgc 22380
aggacctgct cgaaaactgg ttagctgcac agccggcatc attcacacag cagcgggcgt 22440
cattgttagc tatttgcacc acacttctgc cccagcggtt ttgggtgatt ttggttcgct 22500
cgggattctc ctttaaggct cgttgtccgt tctcgctggc cacatccatc tcgataatct 22560
gctccttctg aatcataata ttgccatgca ggcacttcag cttgccctca taatcattgc 22620
agccatgagg ccacaacgca cagcctgtac attcccaatt atggtgggcg atctgagaaa 22680
aagaatgtat cattccctgc agaaatcttc ccatcatcgt gctcagtgtc ttgtgactag 22740
tgaaagttaa ctggatgcct cggtgctcct cgtttacgta ctggtgacag atgcgcttgt 22800
attgttcgtg ttgctcaggc attagtttaa aagaggttct aagttcgtta tccagcctgt 22860
acttctccat cagcagacac atcacttcca tgcctttctc ccaagcagac accaggggca 22920
agctaatcgg attcttaaca gtgcaggcag cagctccttt agccagaggg tcatctttag 22980
cgatcttctc aatgcttctt ttgccatcct tctcaacgat gcgcacgggc gggtagctga 23040
aacccactgc tacaagttgc gcctcttctc tttcttcttc gctgtcttga ctgatgtctt 23100
gcatggggat atgtttggtc ttccttggct tctttttggg gggtatcgga ggaggaggac 23160
tgtcgctccg ttccggagac agggaggatt gtgacgtttc gctcaccatt accaactgac 23220
tgtcggtaga agaacctgac cccacacggc gacaggtgtt tctcttcggg ggcagaggtg 23280
gaggcgattg cgaagggctg cggtccgacc tggaaggcgg atgactggca gaaccccttc 23340
cgcgttcggg ggtgtgctcc ctgtggcggt cgcttaactg atttccttcg cggctggcca 23400
ttgtgttctc ctaggcagag aaacaacaga catggaaact cagccattgc tgtcaacatc 23460
gccacgagtg ccatcacatc tcgtcctcag cgacgaggaa aaggagcaga gcttaagcat 23520
tccaccgccc agtcctgcca ccacctctac cctagaagat aaggaggtcg acgcatctca 23580
tgacatgcag aataaaaaag cgaaagagtc tgagacagac atcgagcaag acccgggcta 23640
tgtgacaccg gtggaacacg aggaagagtt gaaacgcttt ctagagagag aggatgaaaa 23700
ctgcccaaaa caacgagcag ataactatca ccaagatgct ggaaataggg atcagaacac 23760
cgactacctc atagggcttg acggggaaga cgcgctcctt aaacatctag caagacagtc 23820
gctcatagtc aaggatgcat tattggacag aactgaagtg cccatcagtg tggaagagct 23880
cagccgcgcc tacgagctta acctcttttc acctcgtact ccccccaaac gtcagccaaa 23940
cggcacctgc gagccaaatc ctcgcttaaa cttttatcca gcttttgctg tgccagaagt 24000
actggctacc tatcacatct tttttaaaaa tcaaaaaatt ccagtctcct gccgcgctaa 24060
tcgcacccgc gccgatgccc tactcaatct gggacctggt tcacgcttac ctgatatagc 24120
ttccttggaa gaggttccaa agatcttcga gggtctgggc aataatgaga ctcgggccgc 24180
aaatgctctg caaaagggag aaaatggcat ggatgagcat cacagcgttc tggtggaatt 24240
ggaaggcgat aatgccagac tcgcagtact caagcgaagc atcgaggtca cacacttcgc 24300
atatcccgct gtcaacctgc cccctaaagt catgacggcg gtcatggacc agttactcat 24360
taagcgcgca agtccccttt cagaagacat gcatgaccca gatgcctgtg atgagggtaa 24420
accagtggtc agtgatgagc agctaacccg atggctgggc accgactctc ccagggattt 24480
ggaagagcgt cgcaagctta tgatggccgt ggtgctggtt accgtagaac tagagtgtct 24540
ccgacgtttc tttaccgatt cagaaacctt gcgcaaactc gaagagaatc tgcactacac 24600
ttttagacac ggctttgtgc ggcaggcatg caagatatct aacgtggaac tcaccaacct 24660
ggtttcctac atgggtattc tgcatgagaa tcgcctagga caaagcgtgc tgcacagcac 24720
cctgaagggg gaagcccgcc gtgattacat ccgcgattgt gtctatctgt acctgtgcca 24780
cacgtggcaa accggcatgg gtgtatggca gcaatgttta gaagaacaga acttgaaaga 24840
gcttgacaag ctcttacaga aatctcttaa ggttctgtgg acagggttcg acgagcgcac 24900
cgtcgcttcc gacctggcag acctcatctt cccagagcgt ctcagggtta ctttgcgaaa 24960
cggattgcct gactttatga gccagagcat gcttaacaat tttcgctctt tcatcctgga 25020
acgctccggt atcctgcccg ccacctgctg cgcactgccc tccgactttg tgcctctcac 25080
ctaccgcgag tgccccccgc cgctatggag tcactgctac ctgttccgtc tggccaacta 25140
tctctcctac cactcggatg tgatcgagga tgtgagcgga gacggcttgc tggagtgtca 25200
ctgccgctgc aatctgtgca cgccccaccg gtccctagct tgcaaccccc agttgatgag 25260
cgaaacccag ataataggca cctttgaatt gcaaggcccc agcagccaag gcgatgggtc 25320
ttctcctggg caaagtttaa aactgacccc gggactgtgg acctccgcct acttgcgcaa 25380
gtttgctccg gaagattacc acccctatga aatcaagttc tatgaggacc aatcacagcc 25440
tccaaaggcc gaactttcgg cctgcgtcat cacccagggg gcaattctgg cccaattgca 25500
agccatccaa aaatcccgcc aagaatttct actgaaaaag ggtaaggggg tctaccttga 25560
cccccagacc ggcgaggaac tcaacacaag gttccctcag gatgtcccaa cgacgagaaa 25620
acaagaagtt gaaggtgcag ccgccgcccc cagaagatat ggaggaagat tgggacagtc 25680
aggcagagga ggcggaggag gacagtctgg aggacagtct ggaggaagac agtttggagg 25740
aggaaaacga ggaggcagag gaggtggaag aagtaaccgc cgacaaacag ttatcctcgg 25800
ctgcggagac aagcaacagc gctaccatct ccgctccgag tcgaggaacc cggcggcgtc 25860
ccagcagtag atgggacgag accggacgct tcccgaaccc aaccagcgct tccaagaccg 25920
gtaagaagga tcggcaggga tacaagtcct ggcgggggca taagaatgcc atcatctcct 25980
gcttgcatga gtgcgggggc aacatatcct tcacgcggcg ctacttgcta ttccaccatg 26040
gggtgaactt tccgcgcaat gttttgcatt actaccgtca cctccacagc ccctactata 26100
gccagcaaat cccggcagtc tcgacagata aagacagcgg cggcgacctc caacagaaaa 26160
ccagcagcgg cagttagaaa atacacaaca agtgcagcaa caggaggatt aaagattaca 26220
gccaacgagc cagcgcaaac ccgagagtta agaaatcgga tctttccaac cctgtatgcc 26280
atcttccagc agagtcgggg tcaagagcag gaactgaaaa taaaaaaccg atctctgcgt 26340
tcgctcacca gaagttgttt gtatcacaag agcgaagatc aacttcagcg cactctcgag 26400
gacgccgagg ctctcttcaa caagtactgc gcgctgactc ttaaagagta ggcagcgacc 26460
gcgcttattc aaaaaaggcg ggaattacat catcctcgac atgagtaaag aaattcccac 26520
gccttacatg tggagttatc aaccccaaat gggattggcg gcaggcgcct cccaggacta 26580
ctccacccgc atgaattggc tcagcgccgg gccttctatg atttctcgag ttaatgatat 26640
acgcgcctac cgaaaccaaa tacttttgga acagtcagct cttaccacca cgccccgcca 26700
acaccttaat cccagaaatt ggcccgccgc cctagtgtac caggaaagtc ccgctcccac 26760
cactgtatta cttcctcgag acgcccaggc cgaagtccaa atgactaatg caggtgcgca 26820
gttagctggc ggctccaccc tatgtcgtca caggcctcgg cataatataa aacgcctgat 26880
gatcagaggc cgaggtatcc agctcaacga cgagtcggtg agctctccgc ttggtctacg 26940
accagacgga atctttcaga ttgccggctg cgggagatct tccttcaccc ctcgtcaggc 27000
tgttctgact ttggaaagtt cgtcttcgca accccgctcg ggcggaatcg ggaccgttca 27060
atttgtggag gagtttactc cctctgtcta cttcaacccc ttctccggat ctcctgggca 27120
ttacccggac gagttcatac cgaacttcga cgcgattagc gagtcagtgg acggctacga 27180
ttgatgtctg gtgacgcggc tgagctatct cggctgcgac atctagacca ctgccgccgc 27240
tttcgctgct ttgcccggga actcattgag ttcatctact tcgaactccc caaggatcac 27300
cctcaaggtc cggcccacgg agtgcggatt tctatcgaag gcaaaataga ctctcgcctg 27360
caacgaattt tctcccagcg gcccgtgctg atcgagcgag accagggaaa caccacggtt 27420
tccatctact gcatttgtaa tcaccccgga ttgcatgaaa gcctttgctg tcttatgtgt 27480
actgagttta ataaaaactg aattaagact ctcctacgga ctgccgcttc ttcaacccgg 27540
attttacaac cagaagaacg aaacttttcc tgtcgtccag gactctgtta acttcacctt 27600
tcctactcac aaactagaag ctcaacgact acaccgcttt tccagaagca ttttccctac 27660
taatactact ttcaaaaccg gaggtgagct ccaaggtctt cctacagaaa acccttgggt 27720
ggaagcgggc cttgtagtgc taggaattct tgcgggtggg cttgtgatta ttctttgcta 27780
cctatacaca ccttgcttca ctttcttagt ggtgttgtgg tattggttta aaaaatgggg 27840
cccatactag tcttgcttgt tttactttcg cttttggaac cgggttctgc caattacgat 27900
ccatgtctag acttcgaccc agaaaactgc acacttactt ttgcacccga cacaagccgc 27960
atctgtggag ttcttattaa gtgcggatgg gaatgcaggt ccgttgaaat tacacacaat 28020
aacaaaacct ggaacaatac cttatccacc acatgggagc caggagttcc cgagtggtac 28080
actgtctctg tccgaggtcc tgacggttcc atccgcatta gtaacaacac tttcattttt 28140
tctgaaatgt gcgatctggc catgttcatg agcaaacagt attctctatg gcctcctagc 28200
aaggacaaca tcgtaacgtt ctccattgct tattgcttgt gcgcttgcct tcttactgct 28260
ttactgtgcg tatgcataca cctgcttgta accactcgca tcaaaaacgc caataacaaa 28320
gaaaaaatgc cttaacctct ttctgtttac agacatggct tctcttacat ctctcatatt 28380
tgtcagcatt gtcactgccg ctcatggaca aacagtcgtc tctatccctc taggacataa 28440
ttacactctc ataggacccc caatcacttc agaggtcatc tggaccaaac tgggaagcgt 28500
tgattacttt gatataatct gcaacaaaac aaaaccaata atagtaactt gcaacataca 28560
aaatcttaca ttgattaatg ttagcaaagt ttacagcggt tactattatg gttatgacag 28620
atacagtagt caatatagaa attacttggt tcgtgttacc cagttgaaaa ccacgaaaat 28680
gccaaatatg gcaaagattc gatccgatga caattctcta gaaactttta catctcccac 28740
cacacccgac gaaaaaaaca tcccagattc aatgattgca attgttgcag cggtggcagt 28800
ggtgatggca ctaataataa tatgcatgct tttatatgct tgtcgctaca aaaagtttca 28860
tcctaaaaaa caagatctcc tactaaggct taacatttaa tttcttttta tacagccatg 28920
gtttccacta ccacattcct tatgcttact agtctcgcaa ctctgacttc tgctcgctca 28980
cacctcactg taactatagg ctcaaactgc acactaaaag gacctcaagg tggtcatgtc 29040
ttttggtgga gaatatatga caatggatgg tttacaaaac catgtgacca acctggtaga 29100
tttttctgca acggcagaga cctaaccatt atcaacgtga cagcaaatga caaaggcttc 29160
tattatggaa ccgactataa aagtagttta gattataaca ttattgtact gccatctacc 29220
actccagcac cccgcacaac tactttctct agcagcagtg tcgctaacaa tacaatttcc 29280
aatccaacct ttgccgcgct tttaaaacgc actgtgaata attctacaac ttcacataca 29340
acaatttcca cttcaacaat cagcattatc gctgcagtga caattggaat atctattctt 29400
gtttttacca taacctacta cgcctgctgc tatagaaaag acaaacataa aggtgatcca 29460
ttacttagat ttgatattta atttgttctt ttttttttta tttacagtat ggtgaacacc 29520
aatcatggta cctagaaatt tcttcttcac catactcatt tgtgcattta atgtttgcgc 29580
tactttcaca gcagtagcca cagcaacccc agactgtata ggagcatttg cttcctatgc 29640
actttttgct tttgttactt gcatctgcgt atgtagcata gtctgcctgg ttattaattt 29700
tttccaactt atagactgga tccttgtgcg aattgcctac ctgcgccacc atcccgaata 29760
ccgcaaccaa aatatcgcgg cacttcttag actcatctaa aaccatgcag gctatactac 29820
caatattttt gcttctattg cttccctacg ctgtctcaac cccagctgcc tatagtactc 29880
caccagaaca ccttagaaaa tgcaaattcc aacaaccgtg gtcatttctt gcttgctatc 29940
gagaaaaatc agaaattccc ccaaatttaa taatgattgc tggaataatt aatataatct 30000
gttgcaccat aatttcattt ttgatatacc ccctatttga ttttggctgg aatgctccca 30060
atgcacatga tcatccacaa gacccagagg aacacattcc cctacaaaac atgcaacatc 30120
caatagcgct aatagattac gaaagtgaac cacaaccccc actactccct gctattagtt 30180
acttcaacct aaccggcgga gatgactgaa acactcacca cctccaattc cgccgaggat 30240
ctgctcgata tggacggccg cgtctcagaa cagcgactcg cccaactacg catccgccag 30300
cagcaggaac gcgcggccaa agagctcaga gatgtcatcc aaattcacca atgcaaaaaa 30360
ggcatattct gtttggtaaa acaagccaag atatcctacg agatcaccgc tactgaccat 30420
cgcctctctt acgaacttgg cccccaacga caaaaattta cctgcatggt gggaatcaac 30480
cccatagtta tcacccagca aagtggagat actaagggtt gcattcactg ctcctgcgat 30540
tccatcgagt gcacctacac cctgctgaag accctatacg gcctaagaga cctgctacca 30600
atgaattaaa aaatgattaa taaaaaatca cttacttgaa atcagcaata aggtctctgt 30660
tgaaattttc tcccagcagc acctcacttc cctcttccca actctggtat tctaaacccc 30720
gttcagcggc atactttctc catactttaa aggggatgtc aaattttagc tcctctcctg 30780
tacccacaat cttcatgtct ttcttcccag atgaccaaga gagtccggct cagtgactcc 30840
ttcaaccctg tctaccccta tgaagatgaa agcacctccc aacacccctt tataaaccca 30900
gggtttattt ccccaaatgg cttcacacaa agcccaaacg gagttcttac tttaaaatgt 30960
ttaaccccac taacaaccac aggcggatct ctacagctaa aagtgggagg gggacttaca 31020
gtggatgaca ccaacggttt tttgaaagaa aacataagtg ccaccacacc actcgttaag 31080
actggtcact ctataggttt accactagga gccggattgg gaacgaatga aaataaactt 31140
tgtatcaaat taggacaagg acttacattc aattcaaaca acatttgcat tgatgacaat 31200
attaacacct tatggacagg agtcaacccc accgaagcca actgtcaaat catgaactcc 31260
agtgaatcta atgattgcaa attaattcta acactagtta aaactggagc actagtcact 31320
gcatttgttt atgttatagg agtatctaac aattttaata tgctaactac acacagaaat 31380
ataaatttta ctgcagagct gtttttcgat tctactggta atttactaac tagactctca 31440
tccctcaaaa ctccacttaa tcataaatca ggacaaaaca tggctactgg tgccattact 31500
aatgctaaag gtttcatgcc cagcacgact gcctatcctt tcaatgataa ttctagagaa 31560
aaagaaaact acatttacgg aacttgttac tacacagcta gtgatcgcac tgcttttccc 31620
attgacatat ctgtcatgct taaccgaaga gcaataaatg acgagacatc atattgtatt 31680
cgtataactt ggtcctggaa cacaggagat gccccagagg tgcaaacctc tgctacaacc 31740
ctagtcacct ccccatttac cttttactac atcagagaag acgactgaca aataaagttt 31800
aacttgttta tttgaaaatc aattcacaaa atccgagtag ttattttgcc tcccccttcc 31860
catttaacag aatacaccaa tctctcccca cgcacagctt taaacatttg gataccatta 31920
gatatagaca tggttttaga ttccacattc caaacagttt cagagcgagc caatctgggg 31980
tcagtgatag ataaaaatcc atcgggatag tcttttaaag cgctttcaca gtccaactgc 32040
tgcggatgcg actccggagt ctggatcacg gtcatctgga agaagaacga tgggaatcat 32100
aatccgaaaa cggtatcgga cgattgtgtc tcatcaaacc cacaagcagc cgctgtctgc 32160
gtcgctccgt gcgactgctg tttatgggat cagggtccac agtgtcctga agcatgattt 32220
taatagccct taacatcaac tttctggtgc gatgcgcgca gcaacgcatt ctgatttcac 32280
tcaaatcttt gcagtaggta caacacatta ttacaatatt gtttaataaa ccataattaa 32340
aagcgctcca gccaaaactc atatctgata taatcgcccc tgcatgacca tcataccaaa 32400
gtttaatata aattaaatga cgttccctca aaaacacact acccacatac atgatctctt 32460
ttggcatgtg catattaaca atctgtctgt accatggaca acgttggtta atcatgcaac 32520
ccaatataac cttccggaac cacactgcca acaccgctcc cccagccatg cattgaagtg 32580
aaccctgctg attacaatga caatgaagaa cccaattctc tcgaccgtga atcacttgag 32640
aatgaaaaat atctatagtg gcacaacata gacataaatg catgcatctt ctcataattt 32700
ttaactcctc aggatttaga aacatatccc agggaatagg aagctcttgc agaacagtaa 32760
agctggcaga acaaggaaga ccacgaacac aacttacact atgcatagtc atagtatcac 32820
aatctggcaa cagcgggtgg tcttcagtca tagaagctcg ggtttcattt tcctcacaac 32880
gtggtaactg ggctctggtg taagggtgat gtctggcgca tgatgtcgag cgtgcgcgca 32940
accttgtcat aatggagttg cttcctgaca ttctcgtatt ttgtatagca aaacgcggcc 33000
ctggcagaac acactcttct tcgccttcta tcctgccgct tagcgtgttc cgtgtgatag 33060
ttcaagtaca accacactct taagttggtc aaaagaatgc tggcttcagt tgtaatcaaa 33120
actccatcgc atctaatcgt tctgaggaaa tcatccacgg tagcatatgc aaatcccaac 33180
caagcaatgc aactggattg tgtttcaagc aggagaggag agggaagaga cggaagaacc 33240
atgttaattt ttattccaaa cgatctcgca gtacttcaaa ttgtagatcg cgcagatggc 33300
atctctcgcc cccactgtgt tggtgaaaaa gcacagctag atcaaaagaa atgcgatttt 33360
caaggtgctc aacggtggct tccagcaaag cctccacgcg cacatccaag aacaaaagaa 33420
taccaaaaga aggagcattt tctaactcct caatcatcat attacattcc tgcaccattc 33480
ccagataatt ttcagctttc cagccttgaa ttattcgtgt cagttcttgt ggtaaatcca 33540
atccacacat tacaaacagg tcccggaggg cgccctccac caccattctt aaacacaccc 33600
tcataatgac aaaatatctt gctcctgtgt cacctgtagc gaattgagaa tggcaacatc 33660
aattgacatg cccttggctc taagttcttc tttaagttct agttgtaaaa actctctcat 33720
attatcacca aactgcttag ccagaagccc cccgggaaca agagcagggg acgctacagt 33780
gcagtacaag cgcagacctc cccaattggc tccagcaaaa acaagattgg aataagcata 33840
ttgggaaccg ccagtaatat catcgaagtt gctggaaata taataaggca gagtttcttg 33900
taaaaattga ataaaagaaa aatttgccaa aaaaacattc aaaacctctg ggatgcaaat 33960
gcaataggtt accgcgctgc gctccaacat tgttagtttt gaattagtct gcaaaaataa 34020
aaaaaaaaac aagcgtcata tcatagtagc ctgacgaaca gatggataaa tcagtctttc 34080
catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt catcatgatt 34140
aaacaacagc accgaaagtt cctcgcggtg accagcatga ataattcttg atgaagcata 34200
caatccagac atgttagcat cagttaacga gaaaaaacag ccaacatagc ctttgggtat 34260
aattatgctt aatcgtaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34320
aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgtcg cccccggtcc 34380
ctctaaatac acatacaaag cctcatcagc catggcttac cagacaaagt acagcgggca 34440
cacaaagcac aagctctaaa gtgactctcc aacctctcca caatatatat atacacaagc 34500
cctaaactga cgtaatggga gtaaagtgta aaaaatcccg ccaaacccaa cacacacccc 34560
gaaactgcgt caccagggaa aagtacagtt tcacttccgc aatcccaaca ggcgtaactt 34620
cctctttctc acggtacgtg atatcccact aacttgcaac gtcattttcc cacggtcgca 34680
ccgccccttt tagccgttaa ccccacagcc aatcaccaca cgatccacac tttttaaaat 34740
cacctcattt acatattggc accattccat ctataaggta tattattgat gatg 34794
<210> 142
<211> 34125
<212> DNA
<213> 人腺病毒A（Human adenovirus A）
<400> 142
cctatctaat aatatacctt atactggact agtgccaata ttaaaatgaa gtgggcgtag 60
tgtgtaattt gattgggtgg aggtgtggct ttggcgtgct tgtaagtttg ggcggatgag 120
gaagtggggc gcggcgtggg agccgggcgc gccggatgtg acgttttaga cgccatttta 180
cacggaaatg atgttttttg ggcgttgttt gtgcaaattt tgtgttttag gcgcgaaaac 240
tgaaatgcgg aagtgaaaat tgatgacggc aattttatta taggcgcgga atatttaccg 300
agggcagagt gaactctgag cctctacgtg tgggtttcga tacgtgagcg acggggaaac 360
tccacgttgg cgctcaaagg gcgcgtttat tgttctgtca gctgatcgtt tgggtattta 420
atgccgccgt gttcgtcaag aggccactct tgagtgccag cgagaagagt tttctctgcc 480
agctcatttt cacggcgcca ttatgagaac tgaaatgact cccttggtcc tgtcgtatca 540
ggaagctgac gacatattgg agcatttggt ggacaacttt tttaacgagg tacccagtga 600
tgatgatctt tatgttccgt ctctttacga actgtatgat cttgatgtgg agtctgccgg 660
tgaagataat aatgaacagg cggtgaatga gttttttccc gaatcgctta ttttagctgc 720
cagtgagggg ttgtttttac cggagcctcc tgtactttct cctgtctgtg agcctattgg 780
gggcgaatgt atgccacaac tgcaccctga agatatggat ttattgtgct acgagatggg 840
ctttccctgt agcgattcgg aagacgagca agacgagaac ggaatggcgc atgtttctgc 900
atccgcagct gctgctgccg ctgataggga acgtgaggag tttcagttag accatccaga 960
gttgcccgga cacaattgta agtcctgtga gcaccaccgg aatagtactg gaaatactga 1020
cttaatgtgc tctttgtgct atctgcgagc ctacaacatg ttcatttaca gtaagtgtgc 1080
tatgggaggt gggaggtgat ttttttttct taagcagtga aaaataatat tttgttgttt 1140
ttaggtcctg tttccgataa tgagcctgaa cctaatagca ctttggatgg cgatgagcga 1200
ccctcacccc cgaaactagg aagtgcggtt ccagaaggag taataaaacc tgtgcctcag 1260
cgggtgactg ggaggcgtag atgtgctgtg gaaagcattt tggatttgat tcaagaggaa 1320
gaaagagaac aaacagtgcc tgttgatctg tcagtgaaac gccctagatg taattaatgg 1380
actttgagca cctgggcaat aaaatagggg taatgtggtt tttgtgagtc atgtataata 1440
aaactggttt cggttgaagt gtcttgttaa tgtttgtttg ggcgtggtta aacagggata 1500
taaagctggg ttggtgttgc tttgaatagt tcatcttagt aatggagttg gaaactgtgc 1560
tgcaaagttt tcagagcgtt cgccagctct tgcagtatac ctctaaaaac acttcaggtt 1620
tttggaggta tctgtttggc tctaccttaa gcaaggtggt aaatagggtg aaagaagact 1680
atagagagga atttgaaaac atattggccg actgtccagg gcttttggct tcactagacc 1740
tttgttacca cttggtgttt caggaaaaag tggtcagatc cttagatttt tcatctgtgg 1800
gacgaacggt tgcttctatt gcttttttgg caaccatatt ggataaatgg agcgagaaat 1860
cccacctgag ttgggattac atgctggatt acatgtcaat gcagctgtgg agggcatggc 1920
tgaagaggag ggtttgcatt tactcgctgg cgcggccttt gaccatgccg ccgctgccga 1980
cgttgcaaga ggagaaggag gaggagcgga accctgcggt ggtggagaag taaacatgga 2040
acaacaggtg caagaaggcc atgtacttga ctctggcgaa gggcctagtt gcgcagatga 2100
tagagataag caggaaaaaa aagaaagttt aaaggaagct gctgttctta gtaggctaac 2160
tgttaatctg atgtcccgcc cgcgtttgga aactgtatat tggcaggagt tgcaggatga 2220
atttcagcgg ggtgatatgc atttacagta caaatacagt tttgaacaat taaaaaccca 2280
ctggttagag ccatgggagg atatggagtg tgctattaaa gcttttgcta aattggcctt 2340
acgtcctgat tgtagctaca gaattactaa aacagtaacc attacttcat gcgcctatat 2400
tataggtaac ggggcaatag ttgaggtaga tacaagcgac agagttgctt ttagatgtcg 2460
aatgcagggt atgggcccag gggtggtggg tttggatgga attacattta taaatgttag 2520
gtttgctgga gataagttta aaggcattat gttcgaagct aatacctgtc ttgtcttgca 2580
tggtgtttac tttcttaact ttagtaacat ttgtgtagag tcttggaata aggtttctgc 2640
taggggctgt actttttatg gatgttggaa gggtttggtg ggtagaccaa aaagtaaact 2700
gtctgtaaaa aagtgtttgt ttgaaaaatg tgtacttgct ttaattgtag agggggatgc 2760
acatattagg cataatgcag cttcagaaaa tgcctgtttt gtattattga agggaatggc 2820
tattttaaag cataatatgg tttgtggggt gtctgatcaa actatgcgac gttttgttac 2880
ctgtgctgat ggaaattgtc ataccttaaa aactgttcat attgtgagcc acagtagaca 2940
ttgttggcct gtatgtgatc ataacatgtt tatgcgctgt accatacatt taggcttaag 3000
gcggggtatg tttagacctt cccaatgtaa cttcagccac tcaaacatta tgctggaacc 3060
tgaagtgttt tctagagtgt gtttaaatgg ggtatttgat ttatctgtgg aattatgtaa 3120
ggttataaga tataatgatg atactcgaca tcgttgccga cagtgtgagt gtggtagcag 3180
tcatctagaa cttcgtccca ttgtgctaaa tgtaactgag gagctgagaa gtgaccacct 3240
taccctgtct tgcctgcgga ctgactatga gtcaagtgat gaagacgaca actgaggtaa 3300
gtgggtggag ctaggtggga ttataaaagg ctggaagtca actaaaaatt gtttttgttc 3360
ttttaacagc acgatgaacg gaactactca gaacaacgct gcgctttttg atggaggggt 3420
ttttagccct tatttgactt ccaggttacc atattgggcc ggagtacgtc agaatgtggt 3480
aggatctaca gtggacggtc gacctgtggc acctgcaaat tcatcaacat taacctatgc 3540
aactattgga ccctcgcctt tggataccgc cgccgccgct gcagcttccg cggccgcttc 3600
tacggctcgc agtatggcag ctgatttcag cttctacaat cacttggctt cgaatgctgt 3660
gacacgcacc gcagttcgag aggacattct gactgttatg cttgccaagc ttgaaactct 3720
aactgctcag ctggaagagc tatcgcaaaa ggttgaggaa ttagctgatg ctactaccca 3780
taccccagcc caacctgtaa cccaataaag aaaaaactta aattgagatg gtgttatgaa 3840
tctttattga tacttgtttt ttctgacatg gtaagctctt gaccaccgtt ccctatcatt 3900
aagaacacgg tgaatgtgtt ccagtatttt gtaaagatga gcctgtatat taaggtacat 3960
tggcattagg ccatctttgg gatgaaggta ggaccattga agggcttcat gttccgggtt 4020
agtgttgtag ataatccagt catagcaaca acgctgggca tggtgattaa atatatcttt 4080
taacaacaag ctaattgcta atggaagacc tttagtatag gtattgataa aacggttaag 4140
ctgggtggga tgcatccgag gtgacatgat atgaagtttt gattgtattt tgagattggc 4200
aatgttacct gccaaatctc ttcttggatt catattgtgg agaaccacga aaacggtgta 4260
gccagtacac ttgggaaatt tgtcatggag tttagaagga aaggcatgga aaaacttgga 4320
aacgcctttg tgacttccca aattttccat acactcatcc attattatgg caattggacc 4380
gcgagcagcg gcttgagcaa aaatgttttc tggatcagaa acatcatagt tgtggtctag 4440
agttaggtca tcgtaggaca acttaacaaa tttaggacac agcgttccag attgtggaat 4500
aatagttccc tctggtcctg ggacataatt tccctcacaa atttgcattt cccaagattt 4560
aatttcagat gggggaatca tgtccacttg cggaacaata aaaaaaacag tttctggagc 4620
aggtgtaacc agctgggcag aaagcaaatt acgcaacaac tgagacttcc cacagccagt 4680
gggtccataa attaccccaa ttacaggttg caagtgatag tttaacgagg tgcagctgcc 4740
gtcttcgtgg agaagcggag ccacttcatt catcatttgt cggacgcgga tgttttgctt 4800
ggccagttcc cctaacagac gctctccgcc taaggaaagt aactcttgta aagatttgaa 4860
atttttaagt ggctttaggc catcggccat aggcatgtgg tccagggttt gcttcagcag 4920
ttgcaagcga tcccatagct cagttatatt ttctatgcca tctcgatcca gcaaacttcc 4980
tcgttgcggg ggtttggctg gctgttgctg taaggaacga ggcggtgagc atccaaatgg 5040
acgagggttt tgtccttcca gggacgtaat gtgcgcgtca gggttgtttc ggtcacggtg 5100
aatggatgcg ctcctggttg agcgctggcc agtgtgcgct ttaaactgag gcggctggtg 5160
ctgaagcgcg tgtcttctcc ctgtgcttcg gcaaggtagc attttaacat aagatcataa 5220
gacaaagcct ctgtagcgtg gcctttagcc cgtatttttc ctttggaggt gctcccgcag 5280
tgaggacact gaaggcattt aagggcgtac agttttggag ccaaaaaaac agattctgga 5340
gaataagcat ctgcgccaca ataactacaa acagtttcac attcaactga ccaggtcagc 5400
tcaggacatg atggatcaaa aacaagtttc cctccgtact ttttgatgcg tttcttacct 5460
tgcgactcca taaggcggcg tcctttctct gtgacaaaaa gactgtcagt gtctccgtat 5520
acagatttaa ggggtctatc cttcagtggt attccgcggt cctcctcgta caggaattct 5580
gaccactctg acacaaaagc tctagtccaa gcaagtacaa aggaagccac atgggaaggg 5640
taccgatcgt tgttaattaa agggttagaa ctttctaagg tgtgtaaaca catgtctcct 5700
tcttcagcgt ccatgaatgt gattggtttg taggtgtaag tcacgtgttc acaattttct 5760
ggtggtgggc tataaaaagg ggcgggtcct tggtcttcat cgctttcttc tgcttcgctg 5820
tttacgagcg ccaactggtt gggtgagtac acgcgctcaa aggcaggcat tacctctgta 5880
ctcaacgtgt cagtttctat aaacgatgag gatttgatgt ttaatcgccc cgctgcaatt 5940
tctttcatta ggctttcttc catttgatca gaaaaaacta tttttttgtt atctagtttg 6000
gtagcaaaag atccgtacaa ggcattggaa agcagcttgg ctatagatct tagggtttga 6060
tttttgtccc tatcggcccg ttcttttgcg gcaatattga gttgcacata ttcgcgtgcc 6120
aggcatttcc aggtggggaa aatggtggtg cgctcgtcag atagcaagcg taagcgccac 6180
ccgcgattat gcagtgtaac cagatctacg ctggtaacta cttcaccgcg caagctttca 6240
ttggtccagg ctaaacgacc gccttttcta gaacaaaaag gaggaagaac atccaactga 6300
ttttcatctg gggggtcggc atctatagta aaaatgccag gacaaagatt tttgtcaaaa 6360
taatcaattt tgcaagtgta attttccagc gccacctgcc attgccgcac ggccaatgcc 6420
cgctcatagg ggttaagggg aggaccccaa ggcatggggt gtgtgagggc cgatgcatac 6480
atgccgcaaa tatcatatac atatatgggc tcttttagta ctcctatgta agtaggatag 6540
cacctgccgc cacgaatgct ggcgcgaacg tagtcatata gctcatgtga aggcgccagg 6600
atgttgggcc caagatgtgt gcgctgtggt ttttcggcgc ggtacaaaat ttgtctgaaa 6660
attgcatgag agttagagga aatggtagga cgctgaaaca cattaaaatg tgccgcgtca 6720
agacccactg cgtcagtaac aaactgggcg tatgagctac gcagtttttc taccaatgag 6780
gcagtcacaa gtacatccag ggcacaatag tttaatgttt ccccgataag attgtaattt 6840
ttttctcctt tttttttcca tagttcttga tttaggaggt attcctcctt atccttccag 6900
tactcctcca ggggaaaccc atttgcatct gcacggtaag aaccaagcat ataaaactga 6960
tttaccgcct tgtacggaca acatcctttt tctacaggca gggcatacgc ttgtgcagcc 7020
tttcttaaag atgtatgagt aagagcaaag gtatctctga ccattacttt taaatactgg 7080
tatttaaaat cttggtcgtc acaccctccg tgttcccaca gtaggaagtt agttcgcttt 7140
ttgtagtggg gattgggaag ggcaaaagta atatcattaa ataatatttt gccagctctt 7200
ggaataaaat ttctagaaat tttaaagggt ccagggacgt ccaagcggtt attgattacc 7260
tgagcggcaa gaacaatttc atcaaatcca ttaatattgt gtcctactat atacaactct 7320
acaaatcttg gctcaccctt aattgcaggg gctcttttaa gatcttcgta ggaaagatct 7380
tcaagcgcga ctagtccgtt ttcttcttga gcccattgag acaagtgtgg atttttttgt 7440
aaaaaagtca tccaaagatc agtagctaag gaggtttgta agcggtttct ataggtacga 7500
aactgttgac cgaccttcat tttttctggg gttaagcagt agaaagtagt agagtctttt 7560
tcccattggt cccatccaag ttctaatgca agttgtaagg catgtttgac aagattgtca 7620
tccccagaca gtttcatcac cagcataaat gggacaagtt gctttccaaa tgcccccatc 7680
caggtgtagg tttctacatc ataggtaata aaaaggcgct cagtgcgagg atgcgaaccg 7740
attgggaaaa agtggatctc ctgccaccag ttggaagaat ggctgttgat gtgatgaaag 7800
tagaaatctc gtcggcggac agagcattca tgctgatgtt tgtaaaagcg tgcgcagtgt 7860
tcgcatcgtt gcacgggctg tatctgttga atgaggtgta cctggcggcc tcgcaccaga 7920
aagcagatgg gaaaatcaat accacttggc agctgccgtt cgtcctcttc ctcttctgct 7980
gcattgccac taccgtttgg atcctcgaaa gcgagaacgg agagggtgac ggtgcccctc 8040
gacctgcatg tccagatttc agcacgagag gggcggaaac gggaaatcag ggcgtacagc 8100
ctggagctgt ccatggtatc agtcagagag aaaagcatgt ccgcggggac agcgcgcaag 8160
ttgacttcgc acaggcgggt aagagcaggc tggaggtgca ggtaatactt aatttctaga 8220
ggcgtgccgt tggcagagtc tattgcgtga agtattccat gagcccgggg actaaccacg 8280
gttccacggt gcacttttcc aatgcgcctg cttaaaatcg gcggcgcgga cgagctcccg 8340
gaggaagcgg cggttcgggt cctgcgggaa gcgggggaag cggtatgtcg gcctgacgct 8400
ctggcagggg aaggtgttga gcccgaagtt gactggcatg ggcgactacc cggcgattga 8460
tatcttgaat ctgtcggcgt tgtgtaaaca ctaccggccc tgttgttttg aacctgaaag 8520
aaagttcaac agaatcaatc tcagtgtcat ttactgcagc ctgtcttaaa atctcctgaa 8580
cgtcgcctga gttatcttgg taggcaattt ctgccattaa ttgatcaatt tcttcctcct 8640
ggaggtctcc atgtcccgca cgttcaatag tggctgcaag gtcattagat atccgactca 8700
taagctgtga aaatgcgttt agtccaattt cgttccagac tcggctgtat actacccctc 8760
cttcgctgtc ccgagcgcgc ataaccactt gcgccaagtt gagttccacg agccgtgcga 8820
acacgccgta gttgcgcaag cgctgaaaca ggtagtttaa ggtggtggca acgtgttctg 8880
agacgaagaa atacagaatc caccgacgaa gcgtcagctc gttgatgtca cctaaggctt 8940
caagacgttc catggcttcg taaaagtcta ctgcaaaatt gaaaaactgg gagttgcgag 9000
ctgccaccgt caattcttct tccaacagac gaataagctc ggccaccgtc tcgcgcactt 9060
cttgctgaaa tgcgcccgga actatttctt gttcttcctc ttctacctcc attatttctt 9120
cctcgaccac aggtggtggg ggttgtcttc ttcgacgccg gcgaacgggc agcctgtcta 9180
caaatctttc aatcatttcg ccgcgacggc ggcgcatagt ttcggttact gctcgaccgt 9240
tttcacgtgg tcgtaactca aaaactccac ctctaagttc tgtttcatgt aaaatgggaa 9300
atgaggcgtt gcgaggggcg ttaggtaggg atacagcgct gattatgcat tttattattt 9360
gctgcgtagg aactccgcgc aaggagctaa gcgtctgcat atccaccggg tcggagaacc 9420
tttcaagaaa ggcatctagc cagtcacagt cacaaggtag gctaagtttt gtttcttcta 9480
aagtaccagg aagctgagca atgctactaa taatgtaatt gaagtaagct gttttaagcc 9540
cacgaatggt tttaagaagc accacatctt tgggtccggc ttgttgaatt cgcaggcggt 9600
ctgccattcc ccacacgtca ctttgacatc gtccaagatc tttgtagtag tcttgcatta 9660
acctttccac ctctacctcg cggtttccgc gatcagccat gtgcgtgctt ccgtagcctt 9720
gcagcggttg taataaagct aaatctgcca ctacccgttc cgcaagcact gcctgttgaa 9780
tttgggtaag ggtggttgca aagtcatcca catctacaaa gcggtgataa gctcctgcat 9840
taatggtgta gctgcagttt gtcattactg accaattaac agtttgcgtg cctggctgta 9900
cagtttctgt gtatcgcaag cgtgagtaag cccgagagtc aaaaacatag tcattgcagg 9960
tgcgcactag gtattgatag cccacaagga aatgaggagg aggttcgcga tacaacggcc 10020
agccaagcgt agccgcagca cctggagcga gatcttccaa catgaggcgg tggtattcat 10080
atatgtatct ggacatccat gtgatgccgg cagcggtagt tgttgctcgc ataaattcgc 10140
gggctcggtt ccaaatattg cgcaggggta aaaagcgttc aatagttgcc acgctttgac 10200
cggtcaggcg tgcgcagtct tgaatgctct ggacatggaa aaaatgaaag ttggtaagcg 10260
actcccttcc gtggtttggt ggaaaagtca caagggtacc atagcgagga accccggttc 10320
gaaaccggca ggatccgcta tgagcacaag tgaggcgctt gcgcgttgaa cccggccaag 10380
gacccccaga cacggagagg agtctttttt tatttatttt ttcttagatg catcctgtcc 10440
tgcgacaaat gcgacctcag cccagggcaa ccacggcctc agcagcggtg gcgctttcgg 10500
gctctggcga acaggaagag cctcaatgtc ctacattgga gttggaagaa ggagaaggca 10560
tagcccgatt gggcgcccac tctcctgagc gtcacccaag ggtgcagctc gcccgggaca 10620
gtcgcgtggc atttgtgcct cgtcagaaca tgtttcgcga caacagcggg gaggaagctg 10680
aggaaatgcg agactgcagg tttagggccg gtcgcgagct gcgccgcgga tttaatcgcg 10740
agcgactgct gcgtgaggag gactttgagc cagatgaaca ttcggggatt agttctgcac 10800
gggcccatgt atcagcagcc aacttagtaa cagcatatga acaaacggtt acagaggaac 10860
gtaactttca aaaaagcttt aataaccatg tgcgcacact aatagcgcga gaagaagtag 10920
ccattggttt aatgcatctt tgggactttg tagaagctta tgtacataat ccagcaagta 10980
aacccctaac tgcccagctg ttcttaatag ttcaacatag tagagacaat gaaactttta 11040
gggatgcaat gcttaacata gctgaacccc agggtcggtg gttactcgat ttaattaaca 11100
ttctgcagag cattgtggtt caggaacgca gtcttagttt ggcagacaag gtggccgcca 11160
ttaattactc catgttaagt ttgggaaagt tttatgctcg taaaatctac aaaagtccgt 11220
atgttcccat tgacaaggaa gtgaagatag acagctttta tatgcgcatg gctttaaagg 11280
tactaacatt aagcgacgat cttggagtgt accgcaatga ccgaatccac aaagcagtaa 11340
gcgccagtcg ccgcagagag ctaagcgaca aagagcttat gcatagctta caaagggcgc 11400
tgacgggagc aggaacagag gacgagtcgt tctttgatat gggcgcagac ctacggtggc 11460
agccaagcgc tcgcgctttg gaggcagctg gagtggcgtc tgctgacgtc actggcgatg 11520
acgatgacga agaccagtac gaggactgat cggccgtacc ttttgttaga tgcagcgacc 11580
ggcgatcatc gcggagaggg ctcctaacct ggatcccgcg gttttggcgg ccatgcaaag 11640
ccagccttct ggcgttacag cttcagatga ctggacagcg gccatggatc gtattatggc 11700
tttaacggcg cgcagtcctg atgcttttcg ccagcagccc caagctaacc gcttttcggc 11760
cattttggaa gcagtagtgc cgtctcgtac taaccctact cacgagaaag tgttaaccat 11820
tgtaaatgct ttgttggata gcaaagccat ccgcaaagat gaggctggtt taatatacaa 11880
cgctttgctt gagcgcgtgg cacgctataa cagtaccaat gtgcaggcta acttagaccg 11940
gatgggtaca gatgtaaagg aggcgctggc tcaacgagag cgctttcatc gcgatggtaa 12000
tcttggttcg ctagtagcat taaacgcttt tttgagtact cagccggcta atgttccgcg 12060
tggtcaggaa gattatacaa acttcatcag cgccttgcga ctaatggtta ctgaagtgcc 12120
tcaaagtgaa gtgtatcagt ctggacccga ttactttttt caaacgtcca ggcagggttt 12180
gcaaaccgta aacttaactc aggcttttaa aaatttgcaa ggtttgtggg gggttcgtgc 12240
tccagtaggc gatcgttcaa ctttgtccag tttactaaca ccaaactcgc gcctattact 12300
gttgctaatt gcccccttta ccaacaccaa cagtttaagt cgagattcat acctgggtca 12360
cttagttact ttgtaccgcg aagccattgg tcaagcgcag gtagacgaac aaacttatca 12420
agaaataacc agtgttagtc gcgcactggg ccaggaggac actggcagtt tagaggccac 12480
acttaacttt ttactaacta accgtcgcca gcaagtgcct cctcagtaca ctttaaatgc 12540
ggaagaagaa cgcatattgc gctatgtaca gcaatctgta agtttgtatc ttatgcgtga 12600
gggtgccacc cccagtgccg ccttagacat gacagcgcgc aatatggagc cgtccttcta 12660
cgcttccaat cgagctttca ttaatcgctt gatggattac cttcaccgcg ctgcggccat 12720
gaacggggaa tactttacaa atgcaattct aaatccgcat tggttgcccc ctcctggatt 12780
ttacactggt gaatttgatt tgccggaagg aaatgatggc tttttgtggg atgatgttac 12840
ggacagtctg tttagtcctg cagttattgg acaccatggt aaaaaggaag caggtgatga 12900
aggtcccttg cttgactctc gggcgagttc tccattcccc agtttaacta gtttacccgc 12960
cagtgttaac agcggtcgta ccaccagacc ccgactaaca ggtgaaagtg aatacttaaa 13020
tgaccccatc ttgtttccag tgcgcgacaa aaattttccc aacaatggca tagaaagttt 13080
ggtagataaa atgtctcgct ggaaaacata tgcacaagag cggcgagaat gggaggaaag 13140
acagccaaga ccagttcgcc ctcctaggca acgttggcag cgacgcaaaa aaggggcaca 13200
tgcgggggat gaaggaagcg atgactcagc tgacgacagt agtgtattag atttaggagg 13260
gtcaggaaac ccatttgctc atttgcgccc acagggttgc atagggtcat tgtattaaat 13320
tgaataaaag catacttacc aaagccatgg cgaccagtgt tcgtcttatt ttccttcttc 13380
cgttagctgt gaaatgaggc gcgcggtgga actgcagaca gtggcttttc ctgagacacc 13440
acctccctct tacgaaaccg tgatggcagc ggcgccaccc tacgtgcctc cccgctattt 13500
gggtcctacg gagggaagaa acagtatccg ttactcggaa ttgtcaccgt tgtacgatac 13560
cactcgagtg tacttggtgg acaacaagtc ttctgacatt gcttcattga attaccagaa 13620
tgatcacagc aactttttaa ccactgtagt gcaaaataat gactattccc ctatagaggc 13680
tggcacgcaa actattaact ttgatgaaag gtctagatgg ggtggagatt taaaaaccat 13740
cttacatacc aacatgccaa acgtgaacga ttttatgttt accaccaaat ttaaggccag 13800
ggtaatggtg gctaggaaaa caaacaacga aggccaaacc attttagaat atgagtgggc 13860
agaatttgtg ctacccgagg gtaactattc ggaaaccatg actattgact taatgaacaa 13920
tgctattatt gagcattatt tgcgagtagg aagacagcat ggagtgctgg aaagtgacat 13980
tggagttaag tttgacacca gaaactttcg tctgggttgg gaccccgaaa cccaattagt 14040
aactccggga gtgtacacta atgaggcttt tcatccagat atagtactgc ttccaggttg 14100
cggggttgat tttacagaga gcagattaag caacatacta ggtataagaa agaggcagcc 14160
gtttcaggaa ggatttgtga ttatgtatga acacttagag ggaggcaata ttccagctct 14220
tttggatgta aaaaaatacg aaaacagtct gcaggatcaa aacactgtaa gaggagacaa 14280
ctttattgcc ttaaataagg ctgctaggat tgaaccggtt gaaacagacc ccaaaggacg 14340
cagttacaac ttgcttccag acaaaaaaaa tactaaatat cgcagctggt atttggcata 14400
caactacgga gacccagaaa aaggagttcg gtcatggact ctactaacaa ctccagatgt 14460
aacaggcggc tccgaacagg tgtactggtc cctacccgat atgatgcaag atccggtgac 14520
ttttcgctcc tcgcgtcaag ttagcaacta tcctgtagtt gcagcagaat tactgccagt 14580
tcatgctaaa agcttctaca acgagcaagc cgtctactca cagcttattc gccagtcaac 14640
cgcgcttacg cgcgtgttta atcgctttcc cgagaaccag atactggtgc gtccaccagc 14700
cgctaccatc actaccgtca gtgaaaacgt tcccgccctt acagatcacg ggaccctgcc 14760
gctgcgtagc agtatcagtg gagttcagcg agtcaccatc actgacgccc gccgccggac 14820
ctgtccctac gtttacaaag cactgggcat agtttctcca cgagtgcttt ctagtcgcac 14880
tttttaaaaa agtgtggtaa catgtccatt ttggtttcgc caagtaacaa cacgggctgg 14940
ggactgggtg ccgcccgcat gtatggagga gctaaaacaa ggtctagcca acatccagtg 15000
cgcgtacgcg gacattaccg agctccatgg ggcgcgcata cccgaggacg cactggtcgc 15060
accactgtag acgatgttat tgactcggta gtggccgatg ctcgcaagta ccgcgcgccc 15120
gctgaaacag cagggtctac tgttgatgca gtaattgatg aggtagtggc aaacgcgcgg 15180
gcttatgcaa ggcgccgcag acggctgcgt cgccggcgta gaccaaccac cgccatgcgc 15240
gcggccagag cgttggttcg acgggccagg cgcattgggc ggcgagctat gatgcgggca 15300
gccaggcggg ctgcaacgcc tgccggtcga gcgcggagac gggccgcagc tgcggccgca 15360
acagctattg caaacctagc tgctccgcga cgaggaaatg tatactgggt gcgcgactca 15420
gtgaccggga cgcgtgtgcc agttcgtacg cgtccacctc acccttagaa gacaaagagt 15480
gactcaatgt ctgttatgta tgcccagcat gaccaaacgc aagttcaaag aagagctgct 15540
gcaggcctta gcgcctgaaa tatatggccc atcggataac cttaccaagc gcgatatcaa 15600
gcatgttaaa aaacgggaaa aaaaagagga agaagtcgcc gcggcgtcag cagacggcgt 15660
cgagtttgtg cgctcatttg cgcccagacg tagggtacag tggaagggac ggcaagtaaa 15720
acgcattttg cgaccgggca ccacagtggt tttttctccc ggagagcgaa cgattatgcg 15780
tcccctaaag cgcgagtacg acgaagtgta cgcagacgat gacattttgg agcaagcggc 15840
acaacagact ggggaatttg catatggaaa aaaagggcgt tacggagaca aaattgctat 15900
tcctttggac gagggaaatc caacacccag tttaaaggct gtcactttgc aacaagtgtt 15960
gcccgtcctt gggccttcgg aagaaaagcg tggaattaaa agggaagcca tggatgaatt 16020
gcagcctaca atgcaactga tggtgcctaa gcggcaaaag ttagaggacg tactagagca 16080
catgaaggtg gatcctagcg tacagccaga tgtaaaagta cgtccgataa aaaaggtagc 16140
tccaggattg ggagttcaaa cagtggacat tcaaattcct gtgcaaactg cattgggtga 16200
aactatggaa atccaaactt cgccaataaa aacaacggtg aacgcaagcg tgcaaacaga 16260
cccttggtac ccgccagtgc tttcaacaaa aaaaaagcgt cactacagac aaacaagttc 16320
gcttttgcca gactacgttt tacatccttc cattgtgccc acgcctgggt accgtgggac 16380
aacttttcag cgccgagcca cagcccctag ccgtagacga ggtccatcac gccgtagacg 16440
tcgacgcaaa gccactttag ccccagcggc agtacgtcgc gttgtacaaa gggggcgcac 16500
actaatactt ccatccgtgc gttaccaccc tagcattctc taacaagctg cgctgccgtt 16560
ttttcagatg gctcttactt gccgaatgcg catacccatt ccaggataca gaggacgacc 16620
ccgccggagg aaagggctga ccgggaacgg tcgatttcgg cggcgtagta tgcgcagacg 16680
catgaagggt ggggtgctgc ccttcctaat tccacttatt gctgcggcca ttggagccgt 16740
tcccggaatt gcctcagtag ccttgcaggc ttctcgaaaa aattaaaata aaataaaact 16800
tccaacttat tactggtact atgactgttt tatgcagact aaatggaaga catcaatttt 16860
tcgtcgctgg ccccgcgaca cggcacgcgg ccgtacatgg gcacctggaa cgagatcggc 16920
acgagccagc tgaacggggg cgccttcaat tggaacagta tctggagcgg tcttaaaaat 16980
tttggttcca cgattaagac atatggcacc aaggcgtgga acagccaaac cggccagatg 17040
ctaagggaca agttaaaaga ccaaaatttt caacagaaag ttgtagatgg tctggcttcg 17100
ggaattaatg gagttgtaga catagccaat caggctgtac agaaaaaaat tgccaaccgt 17160
ttagagccgc ggcccgacga ggtaatggta gaggaaaagc tgccacctct agaaactgtg 17220
cccggatccg ttccaaccaa aggagaaaag cggccacggc cggatgcaga ggaaacctta 17280
gtaacgcaca caacagaacc gccgtcctat gaggaagcaa taaaacaagg agccgctctg 17340
tcacctacca cctatcccat gaccaagcct attttaccca tggctactag agtgtatgga 17400
aaaaacgaaa atgtgcctat gacccttgag ctgcctcctt tgccagaacc cactatcgcg 17460
gatcccgtag gttccgttcc tgttgcatct gttccagttg catcgacagt gagccgtcca 17520
gcagtgcggc ctgttgccgt ggctagcttg cgaaacccac gatccagtaa ttggcaaagt 17580
accctaaaca gtattgtggg actgggagta aagtctctca aacgccgacg ctgctactaa 17640
cattaaaaga cgagtgttaa ttcccatctg tgtatacgcc tcctatgtta gcgccagagg 17700
accaacgcgt gaatcgcagt caccaccagc gctttcaaga tggccactcc ctcgatgatg 17760
ccgcagtggt cttacatgca catcgccggt caggatgcct cggagtacct gagtcccggt 17820
ctggtgcaat tcgcccgcgc cacggacacc tacttcaccc tgggaaacaa gtttagaaac 17880
cccaccgtgg ctcccaccca tgatgttacc accgatcgct cgcagcgtct gacgctgcgt 17940
tttgtgcccg tggatcggga agatactacc tactcctaca aggctcgctt tacgctggct 18000
gtgggtgaca accgcgtgtt agacatggct agttcttact ttgacattcg aggggtactg 18060
gatcgtggtc ccagttttaa gccctattcc ggaaccgcct acaattcttt ggcaccaaaa 18120
ggcgctccta atgcttcaca atggtcagat aacgctaagc ttaatacctt tgctcaggcg 18180
ccgtatctta gcgacactat caccgccgcc gatggtatta aagttggaac agacaccgcc 18240
caggcaggcg cggcggtgta tgccaacaaa acttatcagc cagagccgca agtaggacca 18300
agtgaatgga acaccagcat tgaaaacgtt aaagctggcg ggagggcatt aaagcaaacc 18360
actgcaatgc agccgtgcta tggctcctac gctcgtccaa ccaacgaaca cggaggacaa 18420
tccaaggatg acaacattga acttaagttc tttgattcag ctaacaatgc agcaaacact 18480
gctcaagttg tgttctatac cgaagacgta aaccttgaaa tgccagacac gcatcttgtg 18540
tttaagccta ctgttaccaa tggaacaatt gcttctgagt cgctgttggg acagcaagca 18600
gcgccaaata gagcaaacta cattgcattc agagataatt ttattggcct gatgtattac 18660
aacagtacag gcaacatggg tgtattggcc gggcaagctt cccaacttaa cgcagtagta 18720
gacctgcaag acagaaatac agagctgtca taccagttaa tgctggatgc tttgggagac 18780
agaacacggt acttttcctt gtggaattcc gcagtggaca gttacgaccc tgacgttcgc 18840
gttattgaga atcacggggt agaggatgaa ctaccaaatt attgctttcc tcttagcgca 18900
gtaggtgaaa taaaaaatta caaaggcatt aagccagata acggaggagg aggtggctgg 18960
actgccgaca acactgtcag tgaagcaaac cacataggca ttgggaatat agccgccatg 19020
gaaattaatt tgcaggctaa tttgtggaga agcttcttgt actcaaatgt gggcttatac 19080
ctaccagacg acttaaaata cactccagga aacataaaac tacctgataa caagaacacc 19140
tacgagtaca tgaacgggcg tgtgactgcc ccggggttgg tggataccta tgtcaatatc 19200
ggcgctcgct ggtccccaga tgtgatggat aatgtaaacc cttttaacca ccaccgaaac 19260
gcagggttgc gctacagatc catgttgcta ggcaatggga gatttgttcc ttttcacatt 19320
caggtgccgc aaaaattttt tgccatcaga aatttgttgc tgttgcccgg ttcctacact 19380
tacgaatgga actttagaaa ggatgtaaac atgattcttc agagcacact gggaaatgat 19440
cttcgggtgg acggagccag cgttcgcttt gacaacattg ccctgtatgc taactttttt 19500
cccatggcac ataacacagc ttctacttta gaagccatgt taagaaatga caccaacgac 19560
cagtctttta acgattattt gtgtgctgca aacatgctgt atcccatccc agctaacgcc 19620
accagcgtgc ccatttcaat accttcgcga aattgggcgg catttagagg ctggagcttt 19680
actcgcctaa aaactaaaga aactccttcc ctgggttcag ggtttgaccc ctactttgta 19740
tactctggaa ccattcccta tttagacggc accttttacc taaaccacac ttttaagaag 19800
gtgtcaatca tgtttgactc ctccgtgagt tggcctggaa atgaccgttt gctaacccca 19860
aatgaatttg aaataaagcg ttctgtggat ggggagggat acaatgtggc ccaatgcaat 19920
atgactaagg attggttcct aatacaaatg cttagtcatt acaacattgg ataccaaggt 19980
ttttacattc cagagagcta caaggaccgc atgtattctt tctttagaaa ctttcagccc 20040
atgagtaggc aagttgtgga taccacagaa tataagaact acaaaaaagt aaccgtagag 20100
tttcaacata acaactcagg attcgtggga tacctgggcc ccactatgcg ggagggacaa 20160
gcttaccccg ccaactatcc ctaccctctt ataggccaaa cagctgtgga aagcatcaca 20220
cagaaaaagt ttctatgcga tcgtgttatg tggcgcatcc cattttctag taacttcatg 20280
tctatggggg cgctaacgga tcttgggcaa aatatgctgt acgcaaactc agcccatgct 20340
ctagacatga catttgaggt ggatccaatg gatgagccta cccttcttta tgttttattt 20400
gaagttttcg acgtggtacg cattcaccag ccacaccgcg gcgtcattga agcggtctac 20460
ctgcgcacgc ccttctcggc gggtaacgct accacctaag aaggcaccct cccagactgc 20520
tgtaatgggt tcaagcgaac aggagctgac ggccattgtt cgagatctag gctgtggacc 20580
ctattttttg ggaacctttg acaaacgttt tccgggtttt gtgtctcgcg accgcttatc 20640
atgtgctatt gttaacactg ccggtcgcga aactgggggc gtacactggc tggcttttgg 20700
atggaacccc aaatcgcaca cttgctattt attcgatcca tttggatttt ctgatcaacg 20760
actaaaacaa atctatcagt ttgagtacga aagtctgttg cgccgtagtg cgctagcggc 20820
cactaaagac cgatgcgtta ccctagaaaa gtcaacccaa actgtacaag gaccgttttc 20880
tgcagcgtgc ggcctgtttt gttgtatgtt cttacacgct tttactcact ggcctgacca 20940
tccaatggat aaaaatccca ctatggacct acttactggg gtgcctaatt gtatgctaca 21000
aagtcctcag gtagtgggca cattgcaacg caatcagaat gaattgtata aattcttaaa 21060
caatctgtcc ccttactttc gtcacaaccg cgagcgcata gaaaaagcta catcttttac 21120
taaaatgcaa aatggactca aataaacgtg tacacaatgc attaataata aaaccatttt 21180
attagctcat tggagtacaa gcttgactgt tttattaaaa atcaaatggc tcttcgcgac 21240
agtcgccgtg gttggtgggc agggatatgt ttctgtactg caaacgctga tgccacttga 21300
attctggaat aacaagccta gggggggagc cgtcaaaatt ttctccccac agctggcgca 21360
caagttgcag ggcgcccata acatcaggag cagaaatctt gaagtcgcaa ttagggccag 21420
cattgccgcg cgcattgcga taaactggat ttgcgcactg aaaaaccaac aaacacggat 21480
acttaatact ggctaacgct ccagggtcgg ttacttcgtt gatatcaatg ttatccacat 21540
tgctgaggtt aaaaggagtg attttacaca gttgacgccc catccgtggc aggccatctt 21600
gcttgtttaa acattcgcag cgcactggca taaggagacg tttttgccca tgtcgcatgt 21660
gagggtagtc ggccagcata aaagcttcaa tttgcctaaa agctatttga gccttcattc 21720
cttcagaata aaacaagccg caggactttc cggagaaaga attattcccg cagccaacat 21780
catgaaaaca gcagcgggca tcgtcgtttt taatttgaac tacattacgc ccccagcggt 21840
tttgcgccac cttggctttc gaggggttct ctttcaacgc tcgttgccca ctttcgctgg 21900
ttacatccat ttccaccaaa tgctctttgc gcaccatctc cattccatgc aggcatctaa 21960
gctccccttc gcgctcggta cacttatgct cccacacgca gcaaccggtg ggttcccagg 22020
aattctgttg gacaccggca taagcttgca tatatccttg caaaaagcgt cccatgagct 22080
cctgaaaggt tttttgggat gaaaaagtca gctgcaaacc gcgcttttct tcgttgagcc 22140
atgttgtgca tattttcttg tacacgctgc cctgatccgg caaaaaacga aaggtggcgc 22200
gctcgtcgtg atccacatgg tacttttcca ttagcatagc catggcttcc atgccttttt 22260
cccaagctga aactaggggc tggcttgccg gattgcgaac aacaacaaca ttcttttcat 22320
tttcgtcgct gttttgagcg gaagccttca aaacgtgtac ctgcctggtt tccatttttt 22380
gaaaagactg agaaccgtct gcatgatgca taatgcggac gggcggcatg ctgaaaccca 22440
ttactcctaa aactgctctt ggtggttctg cctcttcttc ttctgcactc tctggggaaa 22500
gaggtatcgc agccatagat ttcttgactt ttttctttgg aggtaaaggc acagcttcca 22560
gttcttcttc gctttcggaa tccagaaagt atctgcccat ttttggcggc ggcggctgag 22620
cgctgcggtc tggggtgcgc tccctctgtg agtgctgatt gctggccatt atttaatcct 22680
aggcaaagaa acacatgatg gatctggagc cacaggaaag cttaaccgcc cccaccgctc 22740
ccgccattgg cgctacggct gtcatggaga aggacaaaag tctactcata ccccaagacg 22800
caccggttga gcagaacttg ggctacgaga ctccccccga ggaatttgaa ggctttcttc 22860
aaatccaaaa gcaaccaaat gagcaaaacg ctgggctcga ggaccatgac tacctaaacg 22920
agggagatgt cctgtttaaa catctacagc gacaaagcac tatcgttcgc gacgccatat 22980
ctgatcgctc ttcaatacca gtttcaattg cagaactatc ttgcatctac gaacgcaacc 23040
tgttctcccc acgtgtgccc cctaaacggc aagccaacgg cacatgcgag ccaaatcctc 23100
gccttaactt ctacccagtt tttgcagtgc cagaagcact ggcaacatac catattttct 23160
ttaaaaatca caaaataccc ctatcctgtc gagctaaccg cagccgcgca gatgagcttc 23220
ttgctttaag ggctggcgct tccatacctg ggattgtgtc cttggaagag gtgcctaaaa 23280
tttttgaagg tttaggtcgg gatgaaaaac gagcagcaaa tgccctgcaa aaagaaaatg 23340
aacaaaatca ccatgggaat agtgctctaa tagaactgga aggtgacaat gcccgcctgg 23400
cagttttaaa gcgcaatatt gaggttactc actttgccta cccggcagta aatcttccgc 23460
caaaggtaat gagcgcagtg atgaatcagc tactaattaa gcgagcccaa cccattgaca 23520
aagatgcaaa cttgcaagac ccggaggcaa cagatgatgg aaagccggtt gtaagcgacg 23580
agcaattaac taagtggttg ggaacagaca attccaacga actacaacag cggcgtaaac 23640
tcatgatggc cgccgtactt gtaactgtgg aactcgagtg catgcatcgt tttttctccg 23700
acatcaccac attgcgcaaa attgaggaat gtcttcacta cactttccgc catggctacg 23760
tgcgccaagc ctgtaaaatt tctaatgtgg agctgagcaa tctagtttct tacatgggca 23820
tcttgcatga aaaccgattg ggacagaacg tgctacactc aacactacgc gatgaagcac 23880
gcagagatta cgtgcgagac tgcatttacc ttttcctgtt acatacctgg caaactggga 23940
tgggtgtttg gcagcaatgc ttggaagaaa aaaaccttcg agaactaaac aaactgttag 24000
acagagcact aaaatcccta tggaccggtt ttgacgaacg gacagtagct gcagagctag 24060
ctgacataat tttcccagaa aggttaatga taaccttgca aaacggcttg cctgacttta 24120
tgagtcaaag tatgctgcac aattatcgct cttttatatt agagcgttct gggatgcttc 24180
ctagcatgtg ttgtgcactt ccttcagatt ttgtgcctat atattttaga gagtgccccc 24240
ctcccctgtg gagccactgc tacttactac gacttgctaa ctacctagct taccactcag 24300
accttatgac agattcaagc ggcgaaggcc taatggagtg tcactgccgc tgcaatcttt 24360
gcacccccca ccgttctttg gtttgcaata ctgaactatt aagtgaaagt caagtcattg 24420
gtaccttcga aatgcaggga ccgcagtctg acagcaattt cacgacgaac ctaagactta 24480
cccctgggct ttggacttct gcctacctgc gcaaatttga accccaagat taccacgccc 24540
acagtatcaa tttttacgaa gaccaatcca aacccccaaa agcgccacta acggcttgcg 24600
tcattacgca gggaaaaatt ctagcccaat tgcatgctat taagcaagcg cgcgaagagt 24660
ttttacttaa aaaaggacac ggagtgtacc ttgatcccca aaccggcgag gaactaaacc 24720
ttccatcacc tttgtgtgct actgcgtctc cccattcgca gcatgtcccc gaaagccgca 24780
aaacaggcta ttgcgcagca acgctcaaag aaacagcagc aacggcagga aatctgggag 24840
gaagaatctt gggagagtca ggcagaggac gaggtcgagg acttggaaga atgggaggag 24900
gaggaggcgg acagcctaga cgaggatcca gaggaggagg aggaaggttc caaggacgga 24960
gcgaccgccg ccaaaccgtc gctttcaacc aagccctctc caatgaaacc cgctgtgagc 25020
aaatctcaga aagccaaccg tagatgggac accattgaaa ccagcgccgc aaacttgggt 25080
aagaatcgca agcaggcgcg tcggggctac tgctcatggc gggctcacca aagtaatatt 25140
gtagcctgct ttcagcactg cggggggaat atctcatttg caaggcggta tttgctatac 25200
catgatggag tggcgattcc aaggaatgtc ctccattact accgtcatct ctacagcccc 25260
tttgaagagc tcgacaagga accgacctgc aacagccaag cggcccacta gaatcggcaa 25320
cagcagcaac aaggaaagtc ctgaggcgcg cgagttaaga aaacgcattt ttcccacttt 25380
atatgctatt tttcagcaga gtcgaggtca agaacacgaa ctgaaaataa aaaaccgttc 25440
cctgcgttca cttacccgca gctgtctcta cctcaaaagc gaagatcagt tgcaacgcac 25500
cttgcaggac gcagaagctc tgttcaataa atactgctcc ctctcgctta aagagtaaaa 25560
aaagcccgcg cgcggacttt caacaggcgg gaaaagtgac gtcacaacaa gatgagtaaa 25620
gatattccca cgccttacat gtggagcttt caaccccaaa tgggactggc ggccggcgcg 25680
gctcaagact attctagcaa aatgaattgg ttaagcgccg gaccccacat gatttccagg 25740
gtgaatgggg tacgagcccg gcgtaaccaa atactgctag aacaagccgc tctcaccgct 25800
acaccacgta atcaacttaa ccctccctct tggccagctg ccctgatata tcaggaaaat 25860
ccccctccta ccactgtact tttgcctcgc gacgcccagg ccgaagtcca tatgactaac 25920
gctggggcac agcttgcggg cggtgcacgt cacagtttca ggtataaagg tcgcactgag 25980
ccctatccgt ctccagctat aaaaagagta ctcatcagag ggaaaggtat tcagctgaac 26040
gacgaagtca catcgccatt gggagtcaga cccgacggag tgtttcagct cggagggtcc 26100
ggacgttcct cctttaccgc tcgtcaagcc tacctgacac tacagagctc atcctcagct 26160
ccgagatctg gtggtattgg aactctccaa tttgtggagg aatttactcc atctgtttac 26220
ttcaatcctt tttcgggctc gcctggacac tatcctgacg ccttcatacc caactttgac 26280
gcagtgagtg aatctgtgga tggctatgat taatgtctaa tggagcggct gacagagcgc 26340
ggctgcgaca tttagaccac tgtcgccaac ctcactgctt tgctcgagac atctgtgtct 26400
ttacctactt tgagcttcca gaggagcacc cccaggggcc agctcacggt gtcagaataa 26460
cagttgaaaa aggaattgat acacacctca ttaaattttt caccaaacgc ccgctattgg 26520
tggaaaaaga tcaaggaaat actatattaa ctttatattg catttgtcct gttcccggat 26580
tacatgaaga tttctgctgt catttgtgtg ctgaatttaa tcatctgtag tggcgctgta 26640
ccgcctgaag aagaacctaa ctgtcatccg catttaagca acattaaaat caacctttcg 26700
atccctcata tcactcttcg ctgcagtttt ttttccacac atctcacctg gacctttaac 26760
ggaaaacacg ttaccaatac agatataaag tttaaactac acaaagaaaa catcactcta 26820
tttcaaccta ttaacctggg atactaccgc tgctcagctc caccctgtac gcaagcattt 26880
tttgttgctc cagttattga caaacgccct gctccgacaa cagctgctgt cactgagcac 26940
atcaccgagg cagtttctcc ttctaaaggt acagaggaaa ttgtgtactt ttcaaacttt 27000
acaaaccact tagttttaaa ttgttcctgt tctaactcct taatttcatg gtttgctaac 27060
agctctctgt gcaaaacttt ctaccaagga aaacttttgt attctgctaa actcacattg 27120
tgtaaccaga gcaccccttc ccaccttact ctattgccac cttttgttgc cggtcgttac 27180
ttttgcatag gagctgcacg tactagcccc tgtcaacagc attggaattt aacttactgt 27240
cccccaccag tgtcgccctt tgtgatcaat actgaatatt tagactataa tcccttgctt 27300
gcttacggcg gtctcgcagc tcttatttta ttcctgattt ctaacttgtt tctagtgcaa 27360
catttgtatt catactaaca atgctttcca tttttctttt atttctcttt tctttacctt 27420
ctggcttgta tgctcaaaca gccgaaagac cactaaaagt cgtggtggaa gctggccata 27480
atgtaaccct tccccacctt tctggttcac accaaactgg ccatgttact tggctagtag 27540
agacatcaga ttatggttca gcttctccag acaacttcat tttcagtgga caaaaactat 27600
gccagtttac tgacagaacc atggtgtggc cttattacaa tttacatttt aactgtgaaa 27660
attatgacct taatctgttt tggcttaagg tggaaaattc ggctatttac aacgttaaaa 27720
atacagtcaa tgcttctgaa acaaatattt actatgattt aagagtagta caaatttttc 27780
cacctaaatg catcattact tcaaagtacc ttacaaacga ttattgtcac attacaatta 27840
actgcactaa ctctgattac cccaataagg ttgtgtttaa taatgtcagt cgatggtact 27900
acggatacgg taagggcagc ccaacccttc ccaactactt tataactaac tttaatgttt 27960
caggtattac taaaagcttt aatcacactt acccttttaa tgagctctgt gattatccca 28020
catcccaatc tcaacacagt ttaacacata cagtaagcac agtaatcttt ttaggaataa 28080
ttggcttcag cattttgatt attatagcag cctttattta tctgtgctgg catagaaaat 28140
ctttgtgtgt ttctaaaaca gaacctctta tgccgattcc ttactagttt tcttttttct 28200
tacagtatgg tgacggttct tctcatcttt ttatgcctgc cagtcatttt ttcttcttcg 28260
acttttgccg cagtcagtga ccttgatccc gagtgtttag ccccctttgc ggtgtacctg 28320
attttcacat ttgtgactgc tacctgcgtc tgcagtatta ttactctgct aatcacctcg 28380
ctccaatttt ttgattacta ctacgtgaga attgtttacc gcagacacca cccccgttac 28440
caaaaccctc aaattgcggc tcttttgcag ctccaaccat gaaaacagca ttagttcttt 28500
tctttatgtt aatcccagtt tgggctagtt cttgtcaact acataaacca tggaattttt 28560
tagattgtta tactaaagaa acaaactaca taggctgggt ttatggaatt atgtctggct 28620
tagtatttgt ctcctctgta gtttctttac aactgtatgc gcgccttaat tttagttgga 28680
ataagtatac tgatgatctt cccgaatatc caaaccccca ggatgattta cccctaaata 28740
ttgtatttcc agagcccccg cgtcctcctt ctgttgttag ctattttaag ttcaccggtg 28800
aagatgattg aacctgatct agaaattgat ggaagaatca ccgaacagag gctcctcact 28860
gatcgcgcta ggcgacgcca acaggatcaa aaaaataaag agttaattga tttacaaacc 28920
gtgcatcagt gtaaaaaagg acttttttgc ctggtaaaac aagctaccct tcgctatgaa 28980
tctttaccag gcaaagaaca tcaactgtgc tacacgctgc ccactcagcg acaaaccttt 29040
actgcaatgg tgggctcggt acctattaaa gtgtcccaac aagcaggaga acaagaaggc 29100
tctattcggt gcctatgtga taaccctgaa tgtttgtaca ctttaataaa aacactgtgc 29160
ggtttaagaa atcttttacc aatgaattaa ataaattact taccggaaat ctgaaaatac 29220
atcatggtct ccgtgtactc ttataaaatt tccctcttcc caactgtcaa acctgacaga 29280
cttgcaaaca gcaaactttc tccaaatctt aaatggaagg tcagattctt cttcccaatc 29340
cctacccacc atcttcatct tttctagatg aagcgcagca gaacccagta tgctgaagaa 29400
acagaagaaa atgatgactt caaccccgtt tacccttttg acccatttga cacatcagac 29460
gtaccctttg ttacaccccc ttttacttct tccaatggtc ttcaagaaaa accaccaggt 29520
gtattagcac ttaattacaa agaccccatt gtaactgaaa atggaaccct tacactcaag 29580
ctaggggacg gaataaaact taatgcccaa ggtcaactta cagctagtaa taatatcaat 29640
gttttggagc cccttaccaa cacctcacaa ggtcttaaac tttcttggag cgccccccta 29700
gcagtaaagg ctagtgccct cacacttaac acaagagcgc ccttaaccac aacggatgaa 29760
agcttagcct taataaccgc ccctcccatt acagtagagt cttcgcgttt gggcttggcc 29820
accatagccc ctctaagctt agatggaggt ggaaacctag gtttaaatct ttctgctccc 29880
ctggacgtta gtaacaacaa tttgcatctc accactgaaa ctcccttagt tgtaaattct 29940
agcggtgccc tatctgttgc tactgcagac cccataagtg ttcgcaacaa cgctcttacc 30000
ctacctacgg cagatccgtt aatggtgagc tccgatgggt tgggaataag tgtcactagt 30060
cccattacag taataaacgg ttccttagcc ttgtctacaa ctgctcccct caacagcaca 30120
ggatccactt taagtctgtc tgttgccaat cctctgacta tttcacaaga cacattgact 30180
gtttccactg gtaacggtct tcaagtgtcg gggtctcaat tagtaacaag aataggggat 30240
ggtttaacat tcgataatgg ggtcatgaaa gtaaacgttg ccgggggaat gagaacttct 30300
ggcggtagaa taattttaga tgttaattat ccctttgatg cgagcaataa cctgtcctta 30360
agacggggat tgggactaat ttataaccaa tctacaaact ggaacttaac aactgatatt 30420
agtaccgaaa aaggtttaat gtttagtggc aatcaaatag ctcttaatgc aggtcagggg 30480
cttacattta ataatggcca acttagggtt aagttgggag ctggacttat ttttgattca 30540
aacaataaca ttgccttagg cagcagcagc aacactccat acgaccctct gacactgtgg 30600
acaactcctg acccaccacc aaactgcagc ctcatacaag agctagatgc aaaactcacc 30660
ctgtgcttaa caaaaaacgg atctattgtt aatggcattg taagtttagt gggtgttaag 30720
ggtaatctcc taaatatcca aagtactact accactgtag gagtgcattt agtgtttgat 30780
gaacagggaa gattaatcac atcaacccct actgccctgg ttccccaagc ttcgtgggga 30840
tatagacaag gccaatcagt gtctaccaat actgttacca atggtctagg ttttatgcct 30900
aatgtgagtg cttaccctag accaaatgcc agtgaggcta aaagccaaat ggtaagtctc 30960
acgtacttac agggagatac atctaaacct ataacaatga aagttgcatt taatggcatt 31020
acgtcgctaa atggatactc tttaacattc atgtggtcag gtctatcaaa ctatataaat 31080
cagcctttct ctacaccatc ctgctccttt tcttacatta cccaagaata aaaacacaca 31140
caaaacacaa attgcgtact tattgtttat tttttttttt ttttacacta tacgcgtggt 31200
taaactgcct ccttcccatt ttaccttgta tacctccctt tccccctttg tagctgaaaa 31260
caactgcact tgaatatttc gacttaggtt ttttggcgtt agcgtccaca cagtttcttt 31320
acgggcaaag cgagggtcgg tgatggaaac gaatccctcg cccgcacagt cactcaagcg 31380
gcattcccca tccaaaacca ggtccatgat tttatcctac aaaaagtaac aacagtcagt 31440
gtccatcagc cgcccaagga ttctctcgtt gattataatc tccaaataaa attgctcgat 31500
gatgcataat taaacccttt agcagttgct gacgataacg ttcatgccga ctatgtttta 31560
gagggcgaac agtgttttca gcaattactt gaacaacttt taacattagc agtctggtac 31620
gacgagcgca acagcgcatg cgtatctcac ttaagtcttt acaataatca caacacagca 31680
ctaacatgtt atttaaaatt ccataattaa aggcgctcca tccaaaacta actttttcta 31740
acgctaacca ggcatggcca tcatacataa ttttaaagta aattaaatgg cgacctctaa 31800
caaaggtgct tcccacatac atcacctctt taggcattaa atggttaaca acctcccgat 31860
accaaaaaca ccttttgtta attaaggcgc catatacggc cattttgaac cagcgtccca 31920
aaagcatccc agctgacata cactgtagtg aacccggacg ctggcaatga caatgaataa 31980
gccaccgctc atgaccatgt aataattgag taacttcaac atttatagtg gcacaacaca 32040
tacatacact catgtatttt ttcaaaataa acatctcata atcagttaga atcatatccc 32100
acggtattgg ccattcctgc agcactgtaa aacctacaca tgaaggaatg cctcttacct 32160
cacttacatt atgtaaagtc agactattac actcaggcca taaagaattt tccgaagtac 32220
tcaacgtagc ttttgactgt tcctcacagg gcggtagttg gtacttgttg tatggtgcca 32280
atctgtagcg ataccgtctg tcgcgctgca tcgtaaacaa cagacttgcg agcgtcttcg 32340
tacttaaaaa aacaaaacca cgtacgacca ctggttatcg cacctcgtcc tttttgtttg 32400
cagcgttggc gttccgtcaa aaaagcaaag tacaaccact ctcgcaggct tgctaaaatg 32460
tattcagctt caggtgttat cttcaaatca tgatgtttaa taaagcgcag agtatccaca 32520
caggatgcat gggctaaacc aagccatgct atgcaggcag ccgtgtcccg acttacagga 32580
ggaggaggaa tacaaggtag aggcataaaa acttaatcaa gacggtcagc aaggatttga 32640
atgcgtaaat ctcgcaggtg gcagcgatcg cctccgctgt gctggtgaaa gatcacagcc 32700
agatcaaatt gtaagcgatt ttccaaatgt tcaacaacag cttctaaaag agccacagct 32760
ctgatttcga taaacaaaag caaagcaaat gcattatcat gaaactcttc tatcatcaaa 32820
ctgcctgact gaaccattcc caggtaattt tcattcttcc actgttgtat tatttgaaca 32880
cactgatttt gcaggtttaa accgtgaata ttaaaaagct ctgtaagggc gccctccacc 32940
gccatccgca ggcagtactt catatttgct gaaaaaagtc tggatcttca aacacctgca 33000
gtaaattcag tagatttaca ttaggctcca caccttggtc tcgcagctga catcttaatg 33060
ccagttgtat aaaatcatac aaatcagaag ccagcagcaa agaaagttca cctccaggta 33120
caagttccgg agttcccaca gaacatacaa cttgcacaaa tggacccata ttagtaagcg 33180
tggcgccaac gtagacatcg cgcataggag gagttaaata atgcattacc agcagccaaa 33240
actcaggtag cacgtcttta agaaacgtca ccacctcaaa atctaagcca tgcaaatagt 33300
tccgtaaaga ctccggaaac aacacggagt aatgaacaag cgacctctga aacatgcttt 33360
aggttagcct gaaaaataaa aatatgttaa attaaagatg cctggcaaac gggtggaaaa 33420
acaactctac ttaaaagcaa gcgcgcgact ggctgctttg cgcgaacatc gcaaaacacg 33480
tcggaatgat taaacaacaa aacactgagc tccattcttg agcctggata aagcgtttca 33540
gcgccaacaa aaacccctct ggcgttcatg tcgcataatg aaaacaatgt tcccaaatat 33600
ccaggaggaa tatcaactgc tatgtgcaaa tataaaagca caactccatg tggaggtata 33660
acaaaattcg caggagaaaa taacacataa gcattagagt cgccctcttg tttaggcaac 33720
atagccccag gtcccgtaaa atacacataa agagtctcaa aagcagccat aatgccttac 33780
cagaaaaaca gtacaaagcc aggcacagca gacacaatct gccgcaagtg cgcaccttta 33840
atactgaaaa atagtgacgt aaatggccaa agttcgccta cacaacacaa aaaaaacccc 33900
aaaagcccgc gaaaaaaatc acttccgcat atgactcggc ataatacggt gttctcacga 33960
cacgtcacat ccggcgcgcc cggctcccac gccgcgcccc acttcctcat ccgcccaaac 34020
ttacaagcac gccaaagcca cacctccacc caatcaaatt acacactacg cccacttcat 34080
tttaatattg gcactagtcc agtataaggt atattattag atagg 34125
<210> 143
<211> 34775
<212> DNA
<213> 人34型腺病毒（Human adenovirus type 34）
<400> 143
catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60
aaaattgtgg ggtgtgtggt gattggctgt ggggttaacg gctaaacggg gcggcgcggc 120
cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180
acgcataaaa aggctttttt tctcacggaa ctactgactt ttcccacggt atttaacagg 240
aaatgaggta gttttgaccg gatgcaagtg aaaattgctg atttgcgcgc gaaaactgaa 300
tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg 360
ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt 420
ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctacggtatt 480
tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc 540
tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat 600
aatttctgct gagactggaa atgaaatact ggagcttgtg gtgcacgccc tgatgggaga 660
cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt 720
agaggtagag ggatcggagg attctaatga ggaagctgtg aatggctttt ttaccgattc 780
tatgctttta gctgctaatg aaggattaga attagatccg cctttggaca ctttcgatac 840
tccaggggtg attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgggttccgt 900
ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga 960
aaaggagcag tctatgcaga ctgcagcggg tgagggagtg aaggctgcca gtgttggttt 1020
tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa 1080
aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagagcgc actgccactt 1140
tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat 1200
attgagtggg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgagtcacc 1260
atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg 1320
caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga 1380
cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacggc caagacaata 1440
agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaga gtgcaatgta 1500
ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata 1560
taagtagaag cagacctgta tggttagctc ataggagctg gctttcatcc atggaggttt 1620
gggccatttt ggaagacctt agaaagacta ggcaactgtt agaggacgct tcggacggag 1680
tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa 1740
aacaggacta taaagaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag 1800
ctcttaattt gggccatcaa gttcacttta aagaaaaagt tttatcagtt ttagactttt 1860
caaccccagg tagaactgcc gctgctgtgg cttttcttac ttttatatta gataaatgga 1920
tcccgcagac tcatttcagc aggggatacg ttttggattt cgtagccaca gcattgtgga 1980
gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg 2040
gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc 2100
aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt 2160
gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt 2220
taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat 2280
gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtc cagaaagagg gaagggatga 2340
agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc 2400
tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa 2460
acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg 2520
ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat 2580
gtggcctgga gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga 2640
tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt 2700
ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag 2760
tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa 2820
atgcatattc caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca 2880
ctgcgcttct acagatactg gatgttttat tttaattaag ggcaatgcca gcgtaaagca 2940
taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgccggtgg 3000
gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt 3060
ttttgatcac aatgtgttga ccaagtgtac catgcatgca ggtgggcgta gaggaatgtt 3120
tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc 3180
cagaatgagc ctaacaggaa tctttgacat gaacatgcaa atctggaaga tcctgaggta 3240
tgatgatacg agatcgaggg tgcgcgcatg cgaatgcgga ggcaagcatg ccaggttcca 3300
gccggtgtgt gtagatgtga ctgaagatct gagaccggat catttggtta ttgcccgcac 3360
tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt 3420
ggggtggggt tttcagatgg acagattgag taaaaatttg ttttttctgt ctttcagctg 3480
tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540
tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600
tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660
cagctgcagc cgccgccgcc gcctctgttg ccgctaacac tgtgcttgga atgggttact 3720
atggaagtat cgtggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780
agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttatc 3840
agcaggtggc cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900
aaaaaaaaat tccacaatca atgaataaat aaacgagctt gttgttgatt taaaatcaag 3960
tgtttttatt tcatttttcg cgcacggtat gccctagacc accgatctcg atcattgaga 4020
acacggtgga ttttttccag aatcctatag aggtgggatt gaatgtttag atacatgggc 4080
attaggccat ctttggggtg gagatagctc cattgaaggg attcatgctc cggggtagtg 4140
ttgtaaatca cccagtcata acaaggtcgc agtgcatggt gttgcacaat atcttttaga 4200
agtaggctga ttgccacaga taagcccttg gtgtaggtgt ttacaaaccg gttgagctgg 4260
gaggggtgca ttcggggtga aattatgtgc attttggatt ggatttttaa gttggcaata 4320
ttgccgccaa gatctcgtct tgggttcatg ttatgaagga ccaccaagac ggtgtatccg 4380
gtacatttag gaaatttatc gtgtagcttg gatggaaaag cgtggaaaaa tttggagaca 4440
cccttgtgtc ctccgagatt ttccatgcac tcatccatga taatagcaat ggggccgtgg 4500
gcagcagcgc gggcaaacac gttccgtggg tctgacacat catagttatg ttcctgagtt 4560
aaatcatcat aagccatttt aatgaatttg gggcggagag tacccgattg gggtatgaat 4620
gttccttcgg gccccggagc atagttcccc tcacagattt gcatttccca agctttcagt 4680
tccgatggtg gaatcatgtc cacctggggg gctatgaaga acaccgtttc tggggcgggg 4740
gtgattagtt gggatgatag caagtttctg agcaattgag atttgccaca tccggtgggg 4800
ccataaatga ttccgattac aggttgcagg tggtagttta gggaacggca actgccgtct 4860
tctcgaagca agggggccac ctcgttcatc atttccctta catgcatatt ttcccgcacc 4920
aaatccatta ggaggcgctc tcctcctagt gatagaagtt cttgtagtga ggaaaagttt 4980
ttcagcggtt ttagaccgtc agccatgggc attttggaga gagtttgctg caaaagttct 5040
agtctgttcc acagttcagt gatgtgttct atggcatctc gatccagcag acctcctcgt 5100
ttcgcgggtt tggacggctc ctggagtagg gtatgagacg atgggcgtcc agcgctgcca 5160
gggttcggtc cttccagggt ctcagtgttc gagtcagggt tgtttccgtc acagtgaagg 5220
ggtgtgcgcc tgcttgggcg cttgccaggg tgcgcttcag actcattctg ctggtggaga 5280
acttctgtcg cttggcgccc tgtatgtcgg ccaagtagca gtttaccatg agttcgtagt 5340
tgagcgcctc ggctgcgtgg cctttggcgc ggagcttacc tttggaagtt ttcttgcata 5400
ccgggcagta taggcatttc agcgcataca gcttgggcgc aaggaaaatg gattctgggg 5460
agtatgcatc tgcgccgcag gaggcgcaaa cagtttcaca ttccaccagc caggttaaat 5520
ccggttcatt ggggtcaaaa acaagttttc cgccatattt tttgatgcgt ttcttacctt 5580
tggtctccat gagttcgtgt cctcgttgag tgacaaacag gctgtccgta tccccgtaga 5640
ctgattttac aggcctcttc tccagtggag tgcctcggtc ttcttcgtac aggaactctg 5700
accactctga tacaaaggcg cgcgtccagg ccagcacaaa ggaggctatg tgggaggggt 5760
agcgatcgtt gtcaaccagg gggtccacct tttccaaagt atgcaaacac atgtcaccct 5820
cttcaacatc caggaatgtg attggcttgt aggtgtattt cacgtgacct ggggtccccg 5880
ctgggggggt ataaaagggg gcggttcttt gctcttcctc actgtcttcc ggatcgctgt 5940
ccaggaacgt cagctgttgg ggtaggtatt ccctctcgaa ggcgggcatg acctctgcac 6000
tcaggttgtc agtttctaag aacgaggagg atttgatatt gacagtgccg gttgagatgc 6060
ctttcatgag gttttcgtcc atttggtcag aaaacacaat ttttttattg tcaagtttgg 6120
tggcaaatga tccatacagg gcgttggata aaagtttggc aatggatcgc atggtttggt 6180
tcttttcctt gtccgcgcgc tctttggcag cgatgttgag ttggacatac tcgcgtgcta 6240
ggcacttcca ttcggggaag atagttgtca attcatctgg cacgattctc acttgccacc 6300
ctcgattatg caaggtaatt aaatccacac tggtggccac ctcgcctcga aggggttcgt 6360
tggtccaaca gagcctacct cctttcctag aacagaaagg gggaagtggg tctagcataa 6420
gttcatcggg agggtctgca tccatggtaa agattcccgg aagtaaatcc ttatcaaaat 6480
agctgatggg agtggggtca tctaaggcca tttgccattc tcgagctgcc agtgcacgct 6540
catatgggtt aaggggactg ccccagggca tgggatgggt gagtgcagag gcatacatgc 6600
cacagatgtc atagacgtag atgggatcct caaagatgcc tatataggtt ggatagcatc 6660
gcccccctct gatacttgct cgcacatagt catatagttc atgtgatggc gctagcaacc 6720
ccggacccaa gttggtgcga ttgggttttt ctgttctgta gacaatctgg cgaaagatgg 6780
cgtgagaatt ggaagagatg gtgggtcttt gaaaaatgtt gaaatgggca tgaggtagac 6840
ctacagagtc tctgacaaag tgggcataag attcttgaag cttggttacc agttcggcgg 6900
tgacaagtac gtctagggcg cagtagtcaa gtgtttcttg aatgatgtca taacctggtt 6960
ggtttttctt ttcccacagt tcgcggttga gaaggtattc ttcgcgatcc ttccagtact 7020
cttctagcgg aaacccgtct ttgtctgcac ggtaagatcc tagcatgtag aactgattaa 7080
ctgccttgta agggcagcag cccttctcta cgggtagaga gtatgcttga gcagcttttc 7140
gcagcgaagc gtgagtaagg gcgaaggtgt ctctgaccat gactttgaga aattggtatt 7200
tgaagtccat gtcgtcacag gctccctgtt cccagagttg gaagtctacc cgtttcttgt 7260
aggcggggtt gggcaaagcg aaagtaacat cgttgaagag aatcttaccg gctctgggca 7320
taaaattgcg agtgatgcgg aaaggctgtg gtacttccgc tcgattgttg atcacctggg 7380
cagctaggac gatctcgtcg aaaccgttga tgttgtgtcc tacgatgtat aattctatga 7440
aacgcggcgt gcctttgacg tgaggtagct tattgagctc atcaaaggtt aggtctgtag 7500
ggtcagataa ggcgtagtgt tcgagagccc attcgtgcag gtgaggattt gcatgtagga 7560
atgatgacca aagatccacc gccagtgctg tttgtaactg gtcccgatac tgacgaaaat 7620
gctggccaat tgccattttt tctggagtga cacagtagaa ggttctgggg tcttgttgcc 7680
atcgatccca ctttagttta atggctagat cgtgggccat gttgacgaga cgctcttctc 7740
ctgagagttt catgaccagc atgaaaggaa ctagttgttt gccaaaggac cccatccagg 7800
tgtaagtttc cacatcgtag gtcaggaaga gtctttctgt gcgaggatga gagccgatcg 7860
ggaagaactg gatttcctgc caccagttgg aggattggct gttgatgtga tggaagtaga 7920
agtttctgcg gcgcgccgag cattcgtgtt tgtgcttgta cagacggccg cagtagtcgc 7980
agcgttgcac gggttgtatc tcgtgaatga gctgtacctg gcttcccttg acgagaaatt 8040
tcagtgggaa gccgaggcct ggcgattgta tctcgtgctc ttctatattc gctgtatcgg 8100
cctgttcatc ttctgtttcg gtggtggtca tgctgacgag cccccgcggg aggcaagtcc 8160
agacctcggc gcgggagggg cggagctgaa ggaccagagc gcgcaggctg gagctgtcca 8220
gagtcctgag acgctgcgga ctcaggttag taggtaggga cagaagatta acttgcatga 8280
tcttttccag ggcgtgcggg aggttcagat ggtacttgat ttccacaggt tcgtttgtag 8340
agatgtcaat ggcttgcagg gttccgtgtc ctttgggcgc cactaccgta cctttgtttt 8400
ttcttttgat cggtggtggc tctcttgctt cttgcatgct cagaagcgat gacggggacg 8460
cgcgccgggc ggaagcggtt gttccggacc cggaggcatg gctggtagtg gcacgtcggc 8520
gccgcgcacg ggcaggttct ggtactgcgc tctgagaaga cttgcgtgcg ccaccacgcg 8580
tcgattgacg tcttgtatct gacgtctctg ggtgaaagct accggccccg tgagcttgaa 8640
cctgaaagag agttcaacag aatcaatttc ggtatcgtta acggcagctt gtctcagtat 8700
ttcttgtacg tcaccagagt tgtcctggta ggcgatctcc gccatgaact gctcgatttc 8760
ttcctcctga agatctccgc gacccgctct ctcgacggtg gccgcgaggt cattggagat 8820
acggcccatg agttgggaga atgcagtcat gcccgcctcg ttccagacgc ggctgtaaac 8880
cacggccccc tcggagtctc ttgcgcgcat caccacctga gcgaggttaa gctccacgtg 8940
tctggtgaag accgcatagt tgcataggcg ctgaaaaagg tagttgagtg tggtggcaat 9000
gtgttcggcg acgaagaaat acatgatcca tcgtctcagc ggcatttcgc tgacatcgcc 9060
cagagcttcc aagcgctcca tggcctcgta gaagtccacg gcaaaattaa aaaactggga 9120
gtttcgcgcg gacacggtca attcctcctc gagaagacgg atgagttcgg ctatggtggc 9180
ccgtacttcg cgttcgaagg ctcccgggat ctcttcttcc tcttctatct cttcttccac 9240
taacatctct tcttcgtctt caggcggggg cggagggggc acacggcgac gtcgacggcg 9300
cacgggcaaa cggtcgatga atcgttcaat gacctctccg cggcggcggc gcatggtttc 9360
agtgacggcg cggccgttct cgcgcggtcg cagagtaaaa acaccgccgc gcatctcctt 9420
aaagtggtga ctgggaggtt ctccgtttgg gagggagagg gcgctgatta tacattttat 9480
taattggccc gtagggactg cgcgcagaga tctgatcgtg tcaagatcca cgggatctga 9540
aaacctttcg acgaaagcgt ctaaccagtc acagtcacaa ggtaggctga gtacggcttc 9600
ttgtgggcgg gggtggttat gtgttcggtc tgggtcttct gtttcttctt catctcggga 9660
aggtgagacg atgctgctgg tgatgaaatt aaagtaggca gttctaagac ggcggatggt 9720
ggcgaggagc accaggtctt tgggtccggc ttgctggata cgcaggcgat tggccattcc 9780
ccaagcatta tcctgacatc tagcaagatc tttgtagtag tcttgcatga gccgttctac 9840
gggcacttct tcctcacccg ttctgccatg catacgtgtg agtccaaacc cgcgcattgg 9900
ttgtaccagt gccaagtcag ctacgactct ttcggcgagg atggcttgct gtacttgggt 9960
gagggtggct tgaaagtcat caaaatccac aaagcggtgg taagccccgg tattaatggt 10020
gtaagcacag ttggccatga ctgaccagtt aactgtctgg tgaccagggc gcacgagctc 10080
ggtgtattta aggcgcgaat aggcgcgggt gtcaaagatg taatcgttgc aggtgcgcac 10140
cagatactgg taacctataa gaaaatgcgg cggtggttgg cggtagagag gccatcgttc 10200
tgtagctgga gcgccggggg cgaggtcttc caacataagg cggtgatagc cgtagatgta 10260
cctggacatc caggtgattc ctgcggcggt agtagaagcc cgaggaaact cgcgtacgcg 10320
gttccaaatg ttgcgtagcg gcatgaagta gttcattgta ggcacggttt gaccagtgag 10380
gcgcgcgcag tcattgatgc tctatagaca cggagaaaat gaaagcgttc agcgactcga 10440
ctccgtagcc tggaggaacg tgaacgggtt gggtcgcggt gtaccccggt tcgagacttg 10500
tactcgagcc ggccggagcc gcggctaacg tggtattggc actcccgtct cgacccagcc 10560
tacaaaaatc caggatacgg aatcgagtcg ttttgctggt tgccgaatgg cagggaagtg 10620
agtcctattt tttttttttg ccgctcagat gcatcccgtg ctgcgacaga tgcgtcccca 10680
acaacagccc ccctcgcagc agcagcaacc acaaaaggct gtccctgcaa ctactgcaac 10740
tgccgctgtg agcggtgcgg gacagcccgc ctatgatctg gacttggaag agggcgaagg 10800
actggcacgt ctaggtgcgc cttcgcccga gcggcatccg cgagttcaac tgaaaaaaga 10860
ttctcgcgag gcgtatgtgc cccaacagaa cctatttaga gacagaagcg gcgaggagcc 10920
ggaggagatg cgagcttccc gctttaacgc gggtcgtgag ctgcgtcacg gtttggacag 10980
aagacgagtg ttgcgggacg aggatttcga agttgatgaa gtgacaggga tcagtcctgc 11040
cagggcacac gtggctgcag ccaaccttgt atcggcttac gaacagacag taaaggaaga 11100
gcgtaatttc caaaagtctt ttaataatca tgtgcgaacc ctcattgccc gcgaagaagt 11160
cacccttggt ttgatgcatt tgtgggattt gatggaagct atcattcaga accctactag 11220
caaacctctg accgcacagc tgtttctggt ggtgcaacac agcagagaca atgaggcttt 11280
cagagaggcg ctgctcaaca tcaccgaacc cgaggggaga tggttgtatg atcttatcaa 11340
cattctacag agtatcatag tgcaggagcg gagcctgggc ctggccgaga aggtggctgc 11400
catcaattac tcggttttga gcttgggaaa gtattacgct cgcaagatct acaagactcc 11460
atacgttccc atagacaagg aggtgaagat agatgggttc tacatgcgca tgacgctgaa 11520
ggtgttgacc ctgagcgatg atcttggggt gtaccgcaat gacagaatgc atcgcgcggt 11580
gagcgccagc aggaggcgcg agttaagcga cagggaactg atgcacagtt tgcaaagagc 11640
tctaactgga gctggaaccg agggtgagaa ttactttgat atgggagctg acttgcagtg 11700
gcagcctagt cgcagggctc tgaacgccgc gacggcagga tgtgagcttc cttacataga 11760
agaggcggat gaaggcgagg aggaagaggg cgagtacttg gaagactgat ggcacaaccc 11820
gtgttttttg ctagatggaa cagcaagcac cggatcccgc aatgcgggcg gcgctgcaga 11880
gccagccgtc cggcattaac tcctcggacg attggaccca ggccatgcaa cgtatcatgg 11940
cgttgacgac tcgcaacccc gaagccttta gacagcaacc ccaggccaac cgtctatcgg 12000
ccatcatgga agctgtagtg ccttcccgct ctaatcccac tcatgagaag gtcctggcca 12060
tcgtgaacgc gttggtggag aacaaagcta ttcgtccaga tgaggccgga ctggtataca 12120
acgctctctt agaacgcgtg gctcgctaca acagtagcaa tgtgcaaacc aatttggacc 12180
gtatgataac agatgtacgc gaagccgtgt ctcagcgcga aaggttccag cgcgatgcca 12240
acctgggttc gctggtggcg ttaaatgctt tcttgagtac tcagcctgct aatgtgccgc 12300
gtggtcaaca ggattatact aactttttaa gtgctttgag actgatggta tcagaagtac 12360
ctcagagcga agtatatcag tccggtcctg attacttctt tcagactagc agacagggct 12420
tgcagacggt aaatctgagc caagctttta aaaaccttaa aggtttgtgg ggagtgcatg 12480
ccccggtagg agaaagagca accgtgtcta gcttgttaac tccgaactcc cgcctattat 12540
tactgttggt agctcctttc accgacagcg gtagcatcga ccgtaattcc tatttgggtt 12600
acctactaaa cctgtatcgc gaagccatag ggcaaagtca ggtggacgag cagacctatc 12660
aagaaattac ccaagtcagt cgcgctttgg gacaggaaga cactggcagt ttggaagcca 12720
ctctgaactt cttgcttacc aatcggtctc aaaagatccc tcctcaatat gctcttactg 12780
cggaggagga gaggatcctt agatatgtgc agcagagcgt gggattgttt ctgatgcaag 12840
agggggcaac tccgactgca gcactggaca tgacagcgcg aaatatggag cccagcatgt 12900
atgccagtaa ccgacctttc attaacaaac tgctggacta cttgcacaga gctgccgcta 12960
tgaactctga ttatttcacc aatgccatct taaacccgca ctggctgccc ccacctggtt 13020
tctacacggg cgaatatgac atgcccgacc ctaatgacgg atttctgtgg gacgacgtgg 13080
acagcgatgt tttttcacct ctttctgatc atcgcacgtg gaaaaaggaa ggcggcgata 13140
gaatgcattc ttctgcatcg ctgtccgggg tcattggtgc taccgcggct gagcccgagt 13200
ctgcaagtcc ttttcctagt ctaccctttt ctctacacag tgtacgtagc agcgaagtgg 13260
gtagaataag tcgcccgagt ttaatgggcg aagaggagta cctaaacgat tccttgctca 13320
gaccggcaag agaaaaaaat ttcccaaaca atggaataga aagtttggtg gataaaatga 13380
gtagatggaa gacttatgct caggatcaca gagacgagcc tgggatcatg gggactacaa 13440
gtagagcgag ccgtagacgc cagcgccatg acagacagag gggtcttgtg tgggacgatg 13500
aggattcggc cgatgatagc agcgtattgg acttgggtgg gagaggaagg ggcaacccgt 13560
ttgctcattt gcgccctcgc ttgggtggta tgttgtaaaa aaaaataaaa aagaaaaaac 13620
tcaccaaggc catggcgacg agcgtacgtt cgttcttctt tattatctgt gtctagtata 13680
atgaggcgag tcgtgctagg cggagcggtg gtgtatccgg agggtcctcc tccttcgtac 13740
gagagcgtga tgcagcagca gcaggcgacg gcggtgatgc aatccccact ggaggctccc 13800
tttgtgcctc cgcgatacct ggcacctacg gagggcagaa acagcattcg ttactcggaa 13860
ctggcacctc agtacgatac caccaggttg tatctggtgg acaacaagtc ggcggacatt 13920
gcttctctga actatcagaa tgaccacagc aacttcttga ccacggtggt gcaaaacaat 13980
gactttaccc ctacggaagc cagcacccag accattaact ttgatgaacg atcgcggtgg 14040
ggcggtcagc taaaaaccat catgcatact aacatgccca acgtgaacga gtatatgttt 14100
agtaacaagt tcaaagcgcg tgtgatggtg tccagaaaac ctcctgaggg tgttagagta 14160
gacgataatt atgatcataa gcaagatatt ctaaaatacg agtggttcga gtttactttg 14220
ccagaaggca acttttcggt cactatgact atcgacttga tgaacaatgc catcatagac 14280
aattacttga aagtgggcag acagaatgga gtgttggaaa gtgacattgg tgttaagttc 14340
gacactagga acttcaagtt gggatgggat ccagaaacta agttgatcat gcctggggtt 14400
tacacctatg aggccttcca tcctgacatc gtattgctgc ctggctgcgg agtggacttt 14460
accgaaagcc gtctgagcaa ccttcttggc attagaaaga aacacccatt ccaagagggt 14520
tttaagatct tgtatgagga tttagaagga ggaaatattc cagccctttt ggatgtagat 14580
gcttatgaga acagcaagaa agatcaaaaa gccaaaatag aagctgctgc agaagctaaa 14640
gcaaacatag ttgccaacga tccggtaagg gtggctaacg ctagtgaaat caggggagac 14700
agttttgccg caacatccgt tccgactaaa gaatcattat tggatgatgt gtctcaaaac 14760
atagagttaa aactcactat taagcctgtg gaaaaagatg gcaaaaacag aagttacaat 14820
gtgttggaag ataaaatcaa cacggcctat cgcagttggt acctttcgta caattatggc 14880
gaccccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt cacctgcgga 14940
gcggagcagg tctactggtc gcttccagac atgatgcagg atcctgtcac tttccgctcc 15000
actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt cttttcaaag 15060
agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac ctcgcttacg 15120
cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc gcccacaatt 15180
accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc gttgcgcagc 15240
agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac ctgtccctac 15300
gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac tttctaaaaa 15360
aaaaaaaaaa atgtccgttc ttatctcgcc cagtaataac accggttggg gtctgcgcgc 15420
tcccagcaag atgtacggag gcgcacgcaa acgttctacc caacatcccg tgcgtgttcg 15480
cgggcatttt cgcgctccat ggggtgccct caagggccgc actcgcgttc gaaccaccgt 15540
cgatgatgta atcgatcagg tggttgccga cgcccgtaat tatactccta ctgcgcctac 15600
atctactgtg gacgcagtta ttgacagtgt agtggctgac gctcgcaact atgctcgacg 15660
taagagccgg cgaaggcgca ttgccagacg tcaccgagct accactgcca tgcgagcagc 15720
aagagctctg ctacgaagag ctagacgcgt ggggcgaaga gccatgctta gggcggccag 15780
acgtgcagct tcgggcgcca gcgccggcag gtcccgcagg caagcagccg ctgtcgcagc 15840
ggcgactatt gccgacatgg cccaatcgcg aagaggcaat gtatactggg tgcgtgacgc 15900
tgccaccggt caacgtgtac ccgtgcgcac ccgtccccct cgcacttaga agatactgag 15960
cagtctccga tgttgtgtcc cagcggcgag gatgtccaag cgcaaataca aggaagaaat 16020
gctgcaggtt atcgcacctg aagtctacgg ccaaccgttg aaggatgaaa aaaaaccccg 16080
caaaatcaag cgggtaaaaa aggacaaaaa agaagaggaa gatggcgatg atgggctggc 16140
ggagtttgtg cgcgagtttg ccccacggcg acgcgtgcaa tggcgtgggc gcaaagttcg 16200
acatgtgttg agacctggaa cttcggtggt ctttacaccc ggcgagcgtt caagcgctac 16260
ttttaagcgt tcctatgatg aggtgtacgg ggatgatgat attcttgagc aggcagctga 16320
ccgattaggc gagtttgctt atggcaagcg tagtagaata aatcccaagg atgaaacagt 16380
gtccataccc ttggatcatg gaaatcccac ccctagtctt aaaccggtca ctttgcagca 16440
agtgttaccc gtaactccgc gaacaggtgt taaacgcgaa ggtgaagatt tgtatcccac 16500
tatgcaactg atggtgccca aacgccagaa gttggaggac gttttggaga aagtaaaagt 16560
ggatccagat attcaacctg aggttaaagt gagacccatt aagcaggtag cgcctggtct 16620
gggagtacaa actgtagaca ttaaaattcc cactgaaagt atggaagtgc aaactgaacc 16680
cgcaaagcct actgccacct ccactgaagt gcaaacggac ccatggatgc ccatgcctat 16740
tacaactgac gccgtcggtc ccactcgaag atcccgacga aagtacggtc cagcaagtct 16800
gttgatgccc aactatgtcg tacacccatc tattattcct actcctggtt accgaggcac 16860
tcgctactat cgcagccgaa acagtacttc ccgccgtcgc cgcaagacac ctgcaaatcg 16920
cagtcgtcgc cgtagacgca caagcaaacc gattcccggc gccctggtgc ggcaagtgta 16980
ccgcaatggt agtgcggaac ctttgacact gccgcgtgcg cgttaccatc ctagtatcat 17040
cacttaatca atgttgccgc tgcctccttg cagatatggc cctcacttgt cgccttcgcg 17100
ttcccatcac tggttaccga ggaagaaact cgcgccgtag aagagggatg ttggggcgcg 17160
gaatgcgacg ctacaggcga cggcgtgcta tccgcaagca attgcggggt ggttttttgc 17220
cagccttaat tccaattatc gctgctgcga ttggcgcaat accaggcata gcttccgtgg 17280
cggttcaggc ctcgcaacga cattgacatt ggaaaaaaaa aaaacgtata aataaaaaat 17340
acaatggact ctgacactcc tggtactgtg actatgtttt cttagagatg gaagacatca 17400
atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc tggagcgaca 17460
tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg agcgggctta 17520
aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc agtacaggac 17580
aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc gatgggatag 17640
cttccggtat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa aagataaaca 17700
gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa gaaattcctc 17760
cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg ctggtgacgc 17820
gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc accactagac 17880
cgatagcccc tatggccacc ggggtgatga aaccttctca gttgcatcga cccgtcacct 17940
tggatttgcc ccctcctcct gctgctactg ctgtacccgc ttctaagcct gtcgctgccc 18000
cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca aatgcacact 18060
ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa cgccgtcgct 18120
gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg tgtcattaca 18180
cgccgtcaca gcatcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg agttactttc 18240
aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc cggacaggat 18300
gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga cacctacttc 18360
aatctgggaa ataagtttag aaatcctacc gtagcgccga cccacgatgt gaccaccgat 18420
cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa tacatactct 18480
tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat ggccagcacg 18540
ttctttgaca ttaggggcgt gttggacaga ggtcccagtt ttaaacccta ttctggtacg 18600
gcttacaact ccctggctcc taaaggcgct ccaaatgcat ctcagtggtt ggataaggga 18660
gttacaagca ctggcctagt ggacgacggc aatactgatg atggggaaga agccaaaaaa 18720
gcaacataca cttttggtaa tgctccagta aaagccgagg ctgaaatcac aaaagacgga 18780
ttgccggtgg gcttggaagt ttcaactgaa ggtcctaaac caatctatgc tgataagctt 18840
tatcagccag aacctcaagt gggagacgaa acttggactg acctagacgg aaaaaccgaa 18900
gagtatggag ggagggttct taaacctgaa actaaaatga aaccctgcta cggatctttt 18960
gctaaaccta ctaatattaa aggaggtcag gcaaaggtaa aaccaaaaga agacgatggc 19020
actaacaaca tcgagtatga cattgacatg aacttctttg acttaagatc acaaagatca 19080
gaactcaaac ctaaaattgt aatgtatgca gaaaatgtgg acctggaatg tccagatact 19140
catgttgtgt acaaacctgg agtttcagat gctagttctg agaccaatct tggacaacag 19200
tctatgccca acagacccaa ctacattggc ttcagagata acttcatcgg acttatgtac 19260
tataacagta ctggcaacat gggggtactg gctggccaag cgtctcagtt gaatgcagtg 19320
gttgacttgc aggacagaaa cacagaactg tcttaccaac tcttgcttga ctctctgggc 19380
gacagaacca gatactttag catgtggaat caggctgtgg acagttatga tcctgatgta 19440
cgtgttattg aaaatcatgg tgtggaagat gaacttccca actattgttt tccgttggat 19500
ggtgtcggtc cgcgaacaga tagttacaag gagattaagc caaatggaga ccaatctact 19560
tggacaaatg tagacccaac tggcagcagt gaacttgcta agggaaatcc atttgccatg 19620
gaaattaacc ttcaagccaa tctatggcga agtttccttt attccaatgt ggctctatat 19680
ctcccagact cgtacaaata caccccgtcc aatgtcactc ttccagaaaa caaaaacacc 19740
tacgactaca tgaacgggcg ggtggtgccg ccatctctag tagacaccta tgtgaacatt 19800
ggtgccaggt ggtctctgga tgccatggac aatgtcaacc cattcaacca ccaccgtaac 19860
gctggcttgc gttaccgatc catgcttctg ggtaacggac gttatgtgcc tttccacata 19920
caagtgcctc aaaaattctt cgctgttaaa aacctgctgc ttctcccagg ctcctacact 19980
tatgagtgga actttaggaa ggatgtaaac atggttctac agagttccct cggtaacgac 20040
ctacgggtag atggcgccag catcagtttt acgagcatca acctctatgc tacttttttc 20100
cccatggctc acaacaccgc ttccaccctt gaagccatgc tgcggaatga caccaatgat 20160
cagtcattca acgactacct atctgcagct aacatgctct accccattcc tgccaatgca 20220
accaatattc ccatttccat tccttctcgc aactgggcgg ctttcagagg ctggtcattt 20280
accagactga aaaccaaaga aactccctct ttggggtctg gatttgaccc ctacttcgtc 20340
tattctggtt ctattcccta cctggatggt accttctacc tgaaccacac ttttaagaag 20400
gtttccatca tgtttgactc ttcagtgagc tggcctggaa atgacaggtt actatctcct 20460
aacgaatttg aaataaagcg cactgtggat ggcgaaggct acaacgtagc ccaatgcaac 20520
atgaccaaag actggttctt ggtacagatg ctcgccaact acaacatcgg ctatcagggc 20580
ttctacattc cagaaggata caaagatcgc atgtattcat ttttcagaaa cttccagccc 20640
atgagcaggc aggtggttga tgaggtcaat tacaaagact tcaaggccgt cgccataccc 20700
taccaacaca acaactctgg ctttgtgggt tacatggctc cgaccatgcg tcaaggtcaa 20760
ccctatcccg ctaactatcc ctatccactc attggaacaa ctgccgtaaa tagtgttacg 20820
cagaaaaagt tcttgtgtga cagaaccatg tggcgcatac cgttctcaag caacttcatg 20880
tctatgggag cccttacaga cttgggacag aacatgctct atgccaactc agctcatgct 20940
ctggacatga cctttgaggt ggatcccatg gatgagccca ccctgcttta tcttctcttc 21000
gaagttttcg acgtggtcag agtgcatcag ccacaccgcg gcatcatcga ggcagtctac 21060
ctgcgtacac cgttctcggc cggtaacgct accacgtaag aagcttcttg cttcttgcaa 21120
acagcagctg caaccatggc ctgcggatcc caaaacggct ccagcgagca agagctcaga 21180
gccattgtcc aagacctggg ttgcggacca tattttttgg gaacctttga taagcgcttc 21240
ccggggttca tggcccccga taagctcgcc tgtgccattg taaatacggc cggacgtgag 21300
acggggggag agcactggtt ggctttcggt tggaacccac gttctaacac ctgctacctt 21360
tttgatcctt ttggattctc ggatgatcgt ctcaaacaga tttaccagtt tgaatatgag 21420
ggtctcctgc gccgcagcgc tcttgctacc aaggaccggt gtattacgct ggaaaaatct 21480
acccagaccg tgcagggccc ccgttctgcc gcctgcggac ttttctgctg catgttcctt 21540
catgcctttg tgcactggcc tgaccgtccc atggacggaa accccaccat gaaattgcta 21600
actggagtgc caaacaacat gcttcattct cctaaagtcc agcccaccct gtgtgacaat 21660
caaaaagcac tctaccattt tctcaatacc cattcgcctt attttcgctc tcatcgtaca 21720
cacatcgaaa gggccactgc gttcgaccgt atggatgtgc aataatgatt catgtaaaca 21780
acgtgttcaa taaacagcac tttatttttt acatgtatcg aggctctgga ttacttattt 21840
atttacaagt cgaatgggtt ctgacgagaa tcagaatgac ccgcaggcag tgatacgttg 21900
cggaactgat acttgggttg ccacttgaat tcgggaatca ccaacttggg aaccggtata 21960
tcgggcagga tgtcactcca cagctttctg gtcagctgca aagctcccag caggtcagga 22020
gccgaaatct tgaaatcaca attaggacca gtgctctgag cgcgagagtt gcggtacacc 22080
ggattgcagc actgaaacac catcagcgac ggatgtctta cgcttgccag cacggtggga 22140
tctgcaatca tgcccacatc cagatcttca gcattggcaa tgctgaacgg ggtcatcttg 22200
caggtctgcc tacccatggc gggcacccaa ttaggcttgt ggttacaatc gcagtgcagg 22260
gggatcagta tcatcttggc ctgatcctgt ctgattcctg gatacacggc tctcatgaaa 22320
gcatcatatt gcttgaaagc ctgctgggct ttactaccct cggtataaaa catcccgcag 22380
gacctgctcg aaaactggtt agctgcgcag ccggcatcat tcacacagca gcgggcgtca 22440
ttgttggcta tttgcaccac acttctgccc cagcggtttt gggtgatttt ggttcgctcg 22500
ggattctcct tcaaggctcg ttgtccgttc tcgctggcca catccatctc gataatctgc 22560
tccttctgaa tcataatatt gccatgcaag cacttcagct tgccctcata atcattgcag 22620
ccatgaggcc acaacgcaca gcctgtacat tcccaattat ggtgggcgat ctgagaaaaa 22680
gaatgtatca ttccctgcag aaatcttccc atcatcgtgc tcagtgtctt gtgactagtg 22740
aaagttaact ggatgcctcg gtgctcctcg ttcacgtact ggtgacagat gcgcttgtat 22800
tgttcgtgct gctcaggcat tagtttaaaa gaggttctaa gttcgttatc cagcctgtac 22860
ttctccatca gcagacacat cacttccatg cctttctccc aagcagacac caggggcaag 22920
ctaatcggat tcttaacagt gcaggcagca gctcctttag ccagagggtc atctttggcg 22980
atcttctcaa tgcttctttt gccatccttc tcaacgatgc gcacgggcgg gtagctgaaa 23040
cccactgcta caagttgcgc ctcttctctt tcttcttcgc tgtcttgact gatgtcttgc 23100
atggggacat gtttggtctt ccttggcttc tttttcgggg gtatcggagg aggaggactg 23160
tcgctccgtt ccggagacag ggaggattgt gacgtttcgc tcaccattac caactgactg 23220
tcggtagaag aacctgaccc cacacggcga caggtgtttc tcttcggggg cagaggtgga 23280
ggcgattgcg aagggctgcg gtccgacctg gaaggcggat gactggcaga accccttccg 23340
cgttcggggg tgtgctccct gtggcggtcg cttaactgat ttccttcgcg gctggccatt 23400
gtgttctcct aggcagagaa acaacagaca tggaaactca gccattgctg tcaacatcgc 23460
cacgagtgcc atcacatctc gtcctcagcg acgaggaaaa ggagcagagc ttaagcattc 23520
caccgcccag tcctgccacc acctctaccc tagaagataa ggaggtcgac gcatctcatg 23580
acatgcagaa taaaaaagcg aaagagtctg agccagacat cgaacaagac ccgggctatg 23640
tgacaccggt ggaacacgag gaagagttga aacgctttct agagagagag gatgaaaact 23700
gcccaaaaca gcaagcggat aactatcacc aagatgctgg aaatagggat cagaacaccg 23760
actacctcat agggcttgac ggggaagacg cgctccttaa acatctagca agacagtcac 23820
tcatagtcaa ggatgcatta ttggacagaa ctgaagtgcc catcagtgtc gaagagctca 23880
gccgcgccta cgagcttaac ctattttcac ctcgtactcc ccccaaacgt cagccaaacg 23940
gcacctgcga gccaaatcct cgcttaaact tttatccagc ttttgctgtg ccagaagtac 24000
tggctaccta tcacatcttt tttaaaaatc aaaaaattcc agtctcctgc cgcgctaatc 24060
gcacccgcgc cgatgcccta ctcaatctgg gacctggttc acgcttacct gatatagctt 24120
ccttggaaga ggttccaaag atcttcgagg gtctgggcaa taatgagact cgggccgcaa 24180
atgctctgca aaagggagaa aatggcatgg atgagcatca cagcgttctg gtggaattgg 24240
aaggcgataa tgccagactc gcagtactca agcgaagcgt cgaggtcaca cactttgcat 24300
accccgctgt caacctgccc cctaaagtca tgacggccgt catggaccag ttactcatta 24360
agcgcgcaag tcccctttca gaagacatgc atgacccaga tgcctgtgat gagggtaaac 24420
cagtggtcag tgatgagcag ctaacccgat ggctgggcac cgactctccc cgggatttgg 24480
aagagcgtcg caagcttatg atggccgtgg tgctggttac cgtagaacta gagtgtcttc 24540
ggcgtttctt taccgattca gaaaccttgc gcaaactcga agagaatctg cactacactt 24600
ttagacacgg ctttgtgcgg caggcatgca agatatctaa cgtggaactc accaacctgg 24660
tttcctacat gggtattctg catgagaatc gcctaggaca aagcgtgctg cacagcaccc 24720
ttaaggggga agcccgccgt gattacatcc gcgattgtgt ttatctctac ctgtgccaca 24780
cgtggcaaac cggcatgggt gtatggcagc aatgtttaga agaacagaac ctgaaagagc 24840
taaacaagct cttacagaaa tctcttaagg ttctgtggac agggttcgac gagcgcaccg 24900
tcgcttccga cctggcagac ctcatcttcc cagagcgtct cagggttact ttgcgaaacg 24960
gactgcctga ctttatgagc cagagcatgc ttaacaattt tcgctctttc atcctggaac 25020
gctccggtat cctgcccgcc acctgctgcg cactgccctc cgactttgtg cctctcacct 25080
accgcgaatg ccccccgccg ctatggagtc actgctacct gttccgtctg gccaactacc 25140
tctcctacca ctcggatgtg atcgaggatg tgagcggaga cggcttgctg gagtgtcact 25200
gccgctgcaa tctgtgcacg ccccaccggt ccctagcttg caacccccag ttgatgagcg 25260
aaacccagat aataggcacc tttgaattgc aaggccccag cagccaaggc gatgggtctt 25320
ctcctgggca aagtttaaaa ctgaccccgg gactgtggac ctccgcctac ttgcgcaagt 25380
ttgccccgga agattaccac ccctatgaaa tcaagttcta tgaggaccaa tcacagcctc 25440
cgaaagccga actttcggcc tgcgtcatca cccagggggc aattctggcc caattgcaag 25500
ccatccaaaa atcccgccaa gaatttctac tgaaaaaggg taagggggtc taccttgacc 25560
cccagaccgg cgaggaactc aacacaaggt tccctcagga tgtcccaacg acgagaaagc 25620
aagaagttga aggtgcagcc gccgccccca gaagatatgg aggaagattg ggacagtcag 25680
gcagaggaag cggaggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag 25740
gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg 25800
gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt 25860
cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc 25920
ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc 25980
tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat 26040
ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat 26100
agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa 26160
accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac 26220
agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc 26280
catcttccag cagagtcggg gccaagagca ggaactgaaa ataaaaaacc gatctctgcg 26340
ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga 26400
ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac 26460
cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca 26520
cgccttacat gtggagttat cagccccaaa tgggattggc ggcaggcgcc tcccaggact 26580
actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata 26640
tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc 26700
aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca 26760
ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc 26820
agttagcggg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga 26880
tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac 26940
gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg 27000
ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc 27060
aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc 27120
actacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg 27180
attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg 27240
ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca 27300
ccctcaaggt ccggcccacg gagtgcggat tactatcgaa ggcaaaatac actctcgcct 27360
gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt 27420
ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg 27480
tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg 27540
gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct 27600
ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta 27660
ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg 27720
tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct 27780
acctatacac accttgcttc actttcctag tggtgttgtg gtattggttt aaaaaatggg 27840
gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga 27900
tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg 27960
catctgtgga gttcttatta agtgcggatg ggaatgcagg tccgttgaaa ttacacacaa 28020
taacaaaacc tggaacaata ccttatccac cacatgggag ccaggagttc ccgagtggta 28080
cactgtctct gtccgaggtc ctgacggttc catccgcatt agtaacaaca ctttcatttt 28140
ttctgaaatg tgcgatctgg ccatgttcat gagcaaacag tattctctat ggcctcctag 28200
caaggacaac atcgtaacgt tctccattgc ttattgcttg tgcgcttgcc ttcttactgc 28260
tttactgtgc gtatgcatac acctgcttgt aaccactcgc atcaaaaacg ccaataacaa 28320
agaaaaaatg ccttaacctc tttctgttta cagacatggc ttctcttaca tctctcatat 28380
ttgtcagcat tgtcactgcc gctcacggac aaacagtcgt ctctatccct ctaggacata 28440
attacactct cataggaccc ccaatcactt cagaggtcat ctggaccaaa ctgggaagcg 28500
ttgattactt tgatataatc tgcaacaaaa caaaaccaat aatagtaact tgcaacatac 28560
aaaatcttac attgattaat gttagcaaag tttacagcgg ttactattat ggttatgaca 28620
gatacagtag tcaatataga aattacttgg ttcgtgttac ccagttaaaa accacgaaaa 28680
tgccaaatat ggcaaagatt cgatccgatg acaattctct agaaactttt acatctccca 28740
ccacacccga cgaaaaaaac atcccagatt caatgattgc aattgttgca gcggtggcag 28800
tggtgatggc actaataata atatgcatgc ttttatatgc ttgtcgctac aaaaagtttc 28860
atcctaaaaa acaagatctc ctactaaggc ttaacattta atttcttttt atacagccat 28920
ggtttccact accacattcc ttatgcttac tagtcttgca actctgactt ctgctcgctc 28980
acacctcact gtaactatag gctcaaactg cacactaaaa ggacctcaag gtggtcatgt 29040
cttttggtgg agaatatatg acaatggatg gtttacaaaa ccatgtgacc aacctggtag 29100
atttttctgc aacggcagag acctaaccat tatcaacgtg acagcaaatg acaaaggctt 29160
ctattatgga accgactata aaagtagttt agattataac attattgtac tgccatctac 29220
cactccagca ccccgcacaa ctactttctc tagcagcagt gtcgctaaca atacaatttc 29280
caatccaacc tttgccgcgc ttttaaaacg cactgtgaat aattctacaa cttcacatac 29340
aacaatttcc acttcaacaa tcagcattat cgctgcagtg acaattggaa tatctattct 29400
tgtttttacc ataacctact acgcctgctg ctatagaaaa gacaaacata aaggtgatcc 29460
attacttaga tttgatattt aatttgttct tttttttttt atttacagta tggtgaacac 29520
caatcatggt acctagaaat ttcttcttca ccatactcat ttgtgcattt aatgtttgcg 29580
ctactttcac agcagtagcc acagcaaccc cagactgtat aggagcattt gcttcctatg 29640
cactttttgc ttttgttact tgcatctgcg tatgtagcat agtctgcctg gttattaatt 29700
ttttccaact tctagactgg atccttgtgc gaattgccta cctgcgccac catcccgaat 29760
accgcaacca aaatatcgcg gcacttctta gactcatcta aaaccatgca ggctatacta 29820
ccaatatttt tgcttctatt gcttccctac gctgtctcaa ccccagctgc ctatagtact 29880
ccaccagaac accttagaaa atgcaaattc caacaaccgt ggtcatttct tgcttgctat 29940
cgagaaaaat cagaaattcc cccaaattta ataatgattg ctggaataat taatataatc 30000
tgttgcacca taatttcatt tttgatatac cccctatttg attttggctg gaatgctccc 30060
aatgcacatg atcatccaca agacccagag gaacacattc ccctacaaaa catgcaacat 30120
ccaatagcgc taatagatta cgaaagtgaa ccacaacccc cactactccc tgctattagt 30180
tacttcaacc taaccggcgg agatgactga aacactcacc acctccaatt ccgccgagga 30240
tctgctcgat atggacggcc gcgtctcaga acagcgactt gcccaactac gcatccgcca 30300
gcagcaggaa cgcgcggcca aagagctcag agatgtcatc caaattcacc aatgcaaaaa 30360
aggcatattc tgtttggtaa aacaagccaa gatatcctac gagatcaccg ctactgacca 30420
tcgcctctct tacgaacttg gcccccaacg acaaaaattt acctgcatgg tgggaatcaa 30480
ccccatagtt atcacccagc aaagtggaga tactaagggt tgcattcact gctcctgcga 30540
ttccatcgag tgcacctaca ccctgctgaa gaccctatgc ggcctaagag acctgctacc 30600
aatgaattaa aaaatgatta ataaaaaatc acttacttga aatcagcaat aaggtctctg 30660
ttgaaatttt ctcccagcag cacctcactt ccctcttccc aactctggta ttctaaaccc 30720
cgttcagcgg catactttct ccatacttta aaggggatgt caaattttag ctcctctcct 30780
gtacccacaa tcttcatgtc tttcttccca gatgaccaag agagtccggc tcagtgactc 30840
cttcaaccct gtctacccct atgaagatga aagcacctcc caacacccct ttataaaccc 30900
agggtttatt tccccaaatg gcttcacaca aagcccagac ggagttctta ctttaaaatg 30960
tttaacccca ctaacaacca caggcggatc tctacagcta aaagtgggag ggggacttac 31020
agtggatgac actgatggta ccttacaaga aaacatacgt gctacagcac ccattactaa 31080
aaataatcac tctgtagaac tatccattgg aaatggatta gaaactcaaa acaataaact 31140
atgtgccaaa ttgggaaatg ggttaaaatt taacaacggt gacatttgta taaaggatag 31200
tattaacacc ttatggactg gaataaaccc tccacctaac tgtcaaattg tggaaaacac 31260
taatacaaat gatggcaaac ttactttagt attagtaaaa aacggagggc ttgttaatgg 31320
ctacgtgtct ctagttggtg tatcagacac tgtgaaccaa atgttcacac aaaagacagc 31380
aaacatccaa ttaagattat attttgactc ttctggaaat ctattaactg atgaatcaga 31440
cttaaaaatt ccacttaaaa ataaatcttc tacagcgacc agtgaaactg tagccagcag 31500
caaagccttt atgccaagta ctacagctta tcccttcaac accactacta gggatagtga 31560
aaactacatt catggaatat gttactacat gactagttat gatagaagtc tatttccctt 31620
gaacatttct ataatgctaa acagccgtat gatttcttcc aatgttgcct atgccataca 31680
atttgaatgg aatctaaatg caagtgaatc tccagaaagc aacatagcta cgctgaccac 31740
atcccccttt ttcttttctt acattacaga agacgacaac taaaataaag tttaagtgtt 31800
tttatttaaa atcacaaaat tcgagtagtt attttgcctc caccttccca tttgacagaa 31860
tacaccaatc tctccccacg cacagcttta aacatttgga taccattaga gatagacatt 31920
gttttagatt ccacattcca aacagtttca gagcgagcca atctggggtc agtgatagat 31980
aaaaatccat cgcgatagtc ttttaaagcg ctttcacagt ccaactgctg cggatgcgaa 32040
tccggagtct ggatcacggt catctggaag aagaacgatg ggaatcataa tccgaaaacg 32100
gtatcggacg attgtgtctc atcaaaccca caagcagccg ctgtctgcgt cgctccgtgc 32160
aactgctgtt tatgggatca gggtccacag tgtcctgaag catgatttta atagccctta 32220
acatcaactt tctggtgcga tgcgcgcagc aacgcattct gatttcactc aaatctttgc 32280
agtaggtaca acacattatt acaatattgt ttaataaacc ataattaaaa gcgctccagc 32340
caaaactcat atctgatata atcgcccctg catgaccatc ataccaaagt ttaatataaa 32400
ttaaatgacg ttccctcaaa aacacactac ccacatacat gatctctttt ggcatgtgca 32460
tattaacaat ctgtctgtac catggacaac gttggttaat catgcaaccc aatataacct 32520
tccggaacca cactgccaac accgctcccc cagccatgca ttgaagtgaa ccctgctgat 32580
tacaatgaca atgaagaacc caattctctc gaccgtgaat cacttgagaa tgaaaaatat 32640
ctatagtggc acaacataga cataaatgca tgcatcttct cataattttt aactcctcag 32700
gatttagaaa catatcccag ggaataggaa gctcttgcag aacagtaaag ctggcagaac 32760
aaggaagacc acgaacacaa cttacactat gcatagtcat agtatcacaa tctggcaaca 32820
gcgggtggtc ttcagtcata gaagctcggg tttcattttc ctcacaacgt ggtaactggg 32880
ctctggtgta agggtgatgt ctggcgcatg atgtcgagcg tgcgcgcaac cttgtcataa 32940
tggagttgct tcctgacatt ctcgtatttt gtatagcaaa acgcggccct ggcagaacac 33000
actcttcttc gccttctatc ctgccgctta gcgtgttccg tgtgatagtt caagtacagc 33060
cacactctta agttggtcaa aagaatgctg gcttcagttg taatcaaaac tccatcgcat 33120
ctaattgttc tgaggaaatc atccacggta gcatatgcaa atcccaacca agcaatgcaa 33180
ctggattgcg tttcaagcag gagaggagag ggaagagacg gaagaaccat gttaattttt 33240
attccaaacg atctcgcagt acttcaaatt gtagatcgcg cagatggcat ctctcgcccc 33300
cactgtgttg gtgaaaaagc acagctaaat caaaagaaat gcgattttca aggtgctcaa 33360
cggtggcttc caacaaagcc tccacgcgca catccaagaa caaaagaata ccaaaagaag 33420
gagcattttc taactcctca atcatcatat tacattcctg caccattccc agataatttt 33480
cagctttcca gccttgaatt attcgtgtca gttcttgtgg taaatccaat ccacacatta 33540
caaacaggtc ccggagggcg ccctccacca ccattcttaa acacaccctc ataatgacaa 33600
aatatcttgc tcctgtgtca cctgtagcga attgagaatg gcaacatcaa ttgacatgcc 33660
cttggctcta agttcttctt taagttctag ttgtaaaaac tctctcatat tatcaccaaa 33720
ctgcttagcc agaagccccc cgggaacaag agcaggggac gctacagtgc agtacaagcg 33780
cagacctccc caattggctc cagcaaaaac aagattggaa taagcatatt gggaaccgcc 33840
agtaatatca tcgaagttgc tggaaatata atcaggcaga gtttcttgta aaaattgaat 33900
aaaagaaaaa tttgccaaaa aaacattcaa aacctctggg atgcaaatgc aataggttac 33960
cgcgctgcgc tccaacattg ttagttttga attagtctgc aaaaataaaa aaaaaaacaa 34020
gcgtcatatc atagtagcct gacgaacagg tggataaatc agtctttcca tcacaagaca 34080
agccacaggg tctccagctc gaccctcgta aaacctgtca tggtgattaa acaacagcac 34140
cgaaagttcc tcgcggtgac cagcatgaat aattcttgat gaagcataca atccagacat 34200
gttagcatca gttaacgaga aaaaacagcc aacatagcct ttgggtataa ttatgcttaa 34260
tcgtaagtat agcaaagcca cccctcgcgg atacaaagta aaaggcacag gagaataaaa 34320
aatataatta tttctctgct gctgttcagg caacgtcgcc cccggtccct ctaaatacac 34380
atacaaagcc tcatcagcca tggcttacca gacaaagtac agcgggcacg cacaagctct 34440
aaagtcactc tccaacctct ccacaatata tatacacaag ccctaaactg acgtaatggg 34500
agtaaagtgt aaaaaatccc gccaaaccca acacacaccc cgaaactgcg tcaccaggga 34560
aaagtacagt ttcacttccg caatcccaac aagcgtcact tcctctttct cacggtacgt 34620
cacatcccat taacttgcaa cgtcattttc ccacggccgc gccgccccgt ttagccgtta 34680
accccacagc caatcaccac acaccccaca atttttaaaa tcacctcatt tacatattgg 34740
caccattcca tctataaggt atattattga tgatg 34775

Claims (16)

1.一种制备重组腺病毒的方法，包括：
通过不依赖序列和连接反应的克隆法(SLIC)合并可杂交腺病毒目标载体骨架与一个或多个可杂交腺病毒基因模块来组装腺病毒基因组，其中所述的一个或多个可杂交腺病毒基因模块包含E2-L2模块、L3-L4模块、E2-L4模块、E1模块、E3模块、E4模块，或其组合。
2.权利要求1的方法，其中所述的可杂交腺病毒目标载体骨架为腺病毒核心模块目标载体以及一个或多个可杂交腺病毒基因模块，其中所述的腺病毒核心模块目标载体包含E2-L2模块、L3-L4模块、E2-L2模块和L3-L4模块两者、或E2-L4；其中所述的一个或多个可重组的腺病毒基因模块包含E1模块，E3模块，E4模块，或其任意组合。
3.权利要求1或2的方法，其中所述的可杂交目标载体骨架包含p15A复制原点。
4.权利要求1-3任一项的方法，其中所述的可杂交目标载体骨架包含I-SceI哺乳动物表达盒。
5.权利要求2-4任一项的方法，其中所述的核心模块至少长12kb。
6.权利要求2-4任一项的方法，其中所述的核心模块至少长14kb。
7.权利要求2-6任一项的方法，其中所述的核心目标模块包含E2-L2模块和L3-L4模块。
8.权利要求2-6任一项的方法，其中所述的核心模块包含E2-L4模块。
9.权利要求1-8任一项的方法，其中所述的可杂交目标载体骨架和一个或多个可杂交腺病毒基因模块包含长约20至约25碱基对的单链核酸突出。
10.权利要求9的方法，其中所述的可杂交目标载体骨架和一个或多个可杂交腺病毒基因模块在各个末端包含单链核酸突出。
11.权利要求1-10任一项的方法，其中一个或多个可杂交腺病毒基因模块的形成是通过：
将环形的或包含在环形质粒中的腺病毒基因模块与内切核酸酶接触以形成线性的腺病毒基因模块；和
将线性的腺病毒基因模块与外切核酸酶接触以形成一个或多个可杂交的腺病毒基因模块。
12.权利要求1-11任一项的方法，其中所述可杂交目标载体骨架的形成是通过：
将环形目标载体骨架与内切核酸酶接触以形成线性目标载体骨架；和
将线性的目标载体骨架与外切核酸酶接触以形成可杂交目标载体骨架。
13.权利要求1-12任一项的方法，进一步包含转染腺病毒基因组到细胞中。
14.权利要求1-13任一项的方法，其中所述的腺病毒基因组当表达于细胞中时能够形成重组腺病毒。
15.权利要求1-14任一项的方法，其中所述的腺病毒基因组为部分腺病毒基因组构建体，当其表达于感受态细胞系中或表达于具有辅助病毒的细胞中时能够形成重组腺病毒。
16.权利要求1-15任一项的方法，其中相对于基因模块来源的野生型腺病毒，一个或多个可杂交的腺病毒基因模块中的至少一个包含一个或多个修饰。
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