KR20170036118A - 아데노바이러스 조립 방법 - Google Patents

Abstract

본원에서 변형된 아데노바이러스를 조립하는 방법, 아데노바이러스 유전자 모듈로 이루어진 라이브러리 및 그의 조성물을 제공한다.

Description

아데노바이러스 조립 방법{ADENOVIRAL ASSEMBLY METHOD}

관련 출원에 대한 상호 참조

본 출원은 2010년 8월 16일에 출원된 미국 가출원 제61/374,198호의 이점을 주장하며, 이 가출원은 그 전문이 모든 목적을 위해 본원에 참고로 포함된다.

상이한 인간 조직을 감염시키는 인간 아데노바이러스로 52종이 존재하며, 범위가 어류에서부터 영장류까지에 이르는 다른 종을 감염시키는 아데노바이러스로는 수백 종이 존재한다. 이러한 바이러스는 감염 후 1시간 이내에 그의 게놈 페이로드를 핵으로 전달하는 고도로 효율적인 나노기기이다. DNA 바이러스인 상기 바이러스는 숙주 DNA로 통합되지 않기 때문에, 확립된 GMP 프로토콜을 사용하여 고역가로 생산될 수 있고, 이소성 유전자의 발현에 대한 연구 및 인간 유전자 요법 적용에서 안전한 것으로 입증되었다. 그러나, 현재까지는 한 변종, Ad5 또는 Ad2/5 키메라가 거의 전용적으로 사용되고 있다는 점, 및 다중 유전적 변형을 빠르고 체계적으로 조작하고 조합할 수 없는 무능력으로 인해 그의 잠재적인 적용은 이루어지지 못했다. 따라서, Ad2/5 이외의 레퍼토리 아데노바이러스 벡터를 확장시키고, 구성 성분부로부터 신규의 아데노바이러스 게놈을 신속하게 새로 조립하는 것을 촉진시킬 수 있는 기술적 플랫폼을 개발함으로써 다중 변형 및 이종성 요소가 체계적으로 혼입될 수 있도록 하는 것이 크게 요구되고 있다. 그러한 시스템은 36개의 유전자(스플라이스 변이체 포함하지 않음)를 전달하고 발현시키는 것, 둘 모두를 수행하는 데 있어 고도로 효율적인 천연 바이러스 구조를 이용할 것이다. 상기 시스템은 상이한 종양에서 탈조절된 경로 활성의 다중 정량적 측정을 도입한 강력한 진단제 및 치료제를 제공할 수 있다.

여러 적용에 있어 아데노바이러스 벡터의 잠재능은 36 kb의 바이러스 게놈을 빠르고 체계적으로 조작할 수 있는 능력으로 인해 저지된다. 추가로, 기본 연구, 동물 모델, 유전자 요법 및 종양살상형 요법에서 사용되는 아데노바이러스 벡터는 아데노바이러스(Ad: Adenovirus) 혈청형 2 및 5로 제한된다. Ad2 및 Ad5가 그중 발견된 최초의 것이며, 따라서, 특히 E1 영역에서 그의 게놈을 조작할 수 있게 만드는 벡터/도구의 유산이 존재한다. Ad2/5 섬유 단백질은 수용체, CAR에 결합함으로써 상피 세포를 감염시킨다. 불행하게도, CAR은 모든 세포 유형에서 발현되지 않고, 많은 전이에서는 하향조절된다. 추가로, 인간 집단 중 대략 80%는 Ad2/5에 대한 기존 중화 항체를 가지고 있는데, 이는 오프 타겟(off-target) 간 흡수 및 염증과 함께 전신 적용을 제한한다. 따라서, 유전자 전달 및 요법을 위해 Ad2/5 벡터를 사용하는 것만이 반드시 최적의 선택이 되는 것은 아니며, 그와는 정반대로, 대개는 역사적 우연이다.

본 발명자들의 궁극적인 목적은 종양 선택적 용해 복제가 진행될 뿐만 아니라, 치료 회차를 반복하여 전신으로 수행될 수 있고, 간 독성을 회피하고, 구불구불한 종양 혈관구조를 효율적으로 표적화하고 통과하고, 비대응 수용체를 통해 세포를 감염시키고, 종양내 프로드럭 활성화 효소/독소를 국소적으로 발현시킴으로써 종양 방관자 효과를 발생시키고, 유익한 숙주 항종양 면역 반응을 다시 불러 일으키는, 효능이 있는 바이러스 암 요법을 조작하고자 하는 것이다. 이는 마우스에서는 복제가 불가능한 인간 아데노바이러스의 무능력에 의해 추가로 복합화되는 중요한 도전 과제이다. 이는 이종이식 모델에서 많은 이점을 가지고 있는, 면역 수행 능력이 있는, 암을 앓는 유전공학처리된 마우스 모델(GEMM: genetically enginecred mouse model)에서 인간 종양살상형 바이러스 평가를 불가능하게 만든다.

52종의 인간 아데노바이러스가 존재하는데, 이는 상이한 숙주 조직 환경에서 감염 및 복제될 수 있도록 고도로 분화적으로 적합화되어 있다는 것을 시사하는 것이다. 상기 바이러스 다수가 상이한 조직을 감염시키고, CAR 이외의 세포 수용체에 결합하는 섬유 단백질 뿐만 아니라, 상이한 'E3' 면역 조정 유전자 코호트를 가진다. 그의 게놈을 변형을 시키는 데 필요한 도구가 부족하기 때문에 그에 관한 독특한 특성은 광범위하게 연구되지도 사용되지도 못하였다. 유사하게, 다른 종을 감염시키는 아데노바이러스 또한 존재하는데, 그 예로 마우스 아데노바이러스(MAV-1: mouse adenovirus)를 포함한다.

본원에서는 상기와 같은 문제 및 당업계의 다른 문제들에 관한 해결안을 제공한다.

본 발명의 간단한 요약

한 측면에서, 재조합 아데노바이러스를 제조하는 방법(본원에서는 "Ad셈블리(Adsembly)"로도 지칭된다)을 제공한다. 본 방법은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈, 또는 아데노바이러스 마크로모듈(하기 기술되는 바와 같은, 그의 돌연변이체)로부터 선택되는 2개 이상의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다.

또 다른 측면에서, 복수개의 아데노바이러스 유전자 모듈을 포함하는 라이브러리를 제공한다.

또 다른 측면에서, 본원에서 제공하는 방법을 실행하기 위한 키트를 제공한다.

도 1은 현존 아데노바이러스 벡터 방법과 Ad셈블리를 비교한 비교 차트이다. 현 시스템에 존재하는 수개의 한계는 Ad셈블리를 통해 극복될 수 있다.
도 2는 아데노바이러스를 치료제로서 추가로 개발하기 위해서는 극복하여야 하는 도전 과제를 나타내는 것이다. 본 분야에서 극복되어야 할 필요가 있는 주된 문제들 중 일부를 간략하게 도시한 다이어그램이다.
도 3은 4가지의 상이한 아데노바이러스 속을 열거하고 있는 계통수이다. 공지되어 있는 아데노바이러스 모두가 열거되어 있는 것은 아니다. 이는 아데노바이러스과의 종의 다양성을 입증한다.
도 4는 52종의 공지된 인간 아데노바이러스에 대한 수용체 및 향성(tropism)을 나타낸 것이다. 수용체 및 향성은 혈청형과 서브군 사이에 차이가 있으며, 따라서, 이는 특정 바이러스를 재표적화하는 데 사용될 수 있다.
도 5는 아데노바이러스 속 간의 "코어" 게놈 영역의 보존에 관한 것이다. 최상단의 도면은 인간 Ad5 게놈(서열 번호: 137)에 대한 간략화된 지도이며, 코어 영역은 점선 박스로 강조하여 표시되어 있다. 상기 코어 영역은 하단 도면에서 유전자 주변이 흰색 박스로 표시되어 있는 바와 같이, 모든 아데노바이러스 속에 걸쳐 보존된다. 모든 속은 상기 코어 영역을 공유하며, 코어 오픈 리딩 프레임 거의 모두가 IVa2(좌측 말단)에서부터 pVIII(우측 말단)까지 존재한다. 게놈의 변이성은 게놈의 말단에 존재한다. 모듈의 함량이 종간에 다소 차이가 있을 수 있기는 하지만, 그의 코어에 대한 상대적인 위치에는 차이가 없기 때문에, 출원인들은 본 발명자들의 모듈 명칭을 E1 모듈(이는 또한 본원에서 E1 유사 모듈로도 지칭된다)(이들 모두는 코어의 좌측에 위치, 막대로 표시되어 있다), 코어 모듈(막대로 표시되어 있다), 및 E3 모듈(이는 또한 본원에서 E3 유사 모듈로도 지칭된다)(이들 모두는 코어의 우측에 위치, 막대로 표시되어 있다)로 나누었다. 일부 경우에, 섬유 단백질은 코어 바로 옆에 위치하지만, 다른 경우에는 (인간 Ad), 코어 바깥쪽에 위치한다.
도 6은 아데노바이러스 종 간에는 전사 단위가 보존된다는 것을 보여주는 다양한 아데노바이러스 속으로부터의 전사 지도를 나타내는 것이다. 1 또는 2개의 속에서 발견되는 유전자인 코어 유전자가 제시되어 있다. 상기 도는 속 간의 게놈 말단의 변이성을 보여주는 도면을 제공한다. 여기서 인용된 ["Davison, Benko, Harrach"]은 문헌 [Benkoe M et al., (2005) Family Adenoviridae. Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (eds): Virus Taxonomy. VIIIth Report of the International Committee on Taxonomy of Viruses. E1sevier, New York pp 213-228]을 나타내는 것이다.
도 7a-7c는 서열 번호: 32에 기재되어 있는 인간 Ad5 폴리머라제 단백질의 아미노산 966-1103(하단, 컨센서스 바로 위)과, 비인간 아데노바이러스로부터의 수개의 폴리머라제 단백질 중의 상응하는 영역을 함께 정렬해 놓은 것이다. 비인간 Ad 서열 중 임의의 것은 Ad5 폴리머라제 서열과 개별적으로 비교하였을 때, 상기 영역내에서의 동일성이 45% 이상이다. 좌측의 표지는 진뱅크(GenBank) 수탁 번호를 나타내고, 이는 각각 위에서부터 아래로 서열 번호: 1-32에 상응한다.
도 7d-7g는 서열 번호: 73에 기재되어 있는 인간 Ad5 헥손 단백질의 아미노산 501-747(하단, 컨센서스 바로 위)과, 비인간 아데노바이러스로부터의 수개의 헥손 단백질 중의 상응하는 영역을 함께 정렬해 놓은 것이다. 비인간 Ad 서열 중 임의의 것은 Ad5 헥손 서열과 개별적으로 비교하였을 때, 상기 영역내에서의 동일성이 45% 이상이다. 황색으로 강조 표시된 잔기는 종 간에 100% 보존되는 것이다. 좌측의 표지는 진뱅크 수탁 번호를 나타내고, 이는 각각 위에서부터 아래로 서열 번호: 33-73에 상응한다.
도 7h-7i는 서열 번호: 103에 기재되어 있는 인간 Ad5 DNA 결합 단백질의 아미노산 408-475(DBP: DNA-binding protein, 하단, 컨센서스 바로 위)과, 비인간 아데노바이러스로부터의 수개의 DBP 중의 상응하는 영역을 함께 정렬해 놓은 것이다. 비인간 Ad 서열 중 임의의 것은 Ad5 DBP 서열과 개별적으로 비교하였을 때, 상기 영역내에서의 동일성이 35% 이상이다. 황색으로 강조 표시된 잔기는 종 간에 100% 보존되는 것이다. 좌측의 표지는 진뱅크 수탁 번호를 나타내고, 이는 각각 위에서부터 아래로 서열 번호: 74-103에 상응한다.
도 7j는 서열 번호: 135에 기재되어 있는 인간 Ad5 pVIII 단백질의 아미노산 6-43(하단, 컨센서스 바로 위)과, 비인간 아데노바이러스로부터의 수개의 pVIII 단백질 중의 상응하는 영역을 함께 정렬해 놓은 것이다. 비인간 Ad 서열 중 임의의 것은 Ad5 pVIII 서열과 개별적으로 비교하였을 때, 상기 영역내에서의 동일성이 35% 이상이다. 좌측의 표지는 진뱅크 수탁 번호를 나타내고, 이는 각각 위에서부터 아래로 서열 번호: 104-135에 상응한다.
도 8은 아데노바이러스 게놈 조작에 관한 초기 개념을 개략적으로 설명한 것이다.
도 9는 4개의 DNA 단편을 사용한 다중 부위 게이트웨이에 관한 예를 나타낸 간략형 다이어그램이다. 다중 부위 게이트웨이는 게놈 재조립을 위해 본 발명자들이 제안한 시스템이었다. 제안된 시스템은 좌측에 있다.
도 10a는 게이트웨이 att 재조합 부위의 명칭 및 조직을 상세하게 설명해주는 다이어그램이다. 게이트웨이 클로닝으로부터 생성된 4개의 상이한 att 재조합 부위가 존재한다. 4개 모두 실제 재조합이 이루어지는 위치인, 21 bp의 중앙 attB 영역을 함유한다. 특이 효소 믹스(BP)를 사용하여 attP 부위는 attB 부위와 함께 재조합된다. 생성 반응을 통해 attL 및 attR 부위가 형성된다. 상기 반응은 또 다른 효소 믹스(LR)를 통해 가역화될 수 있는데, 여기서는, attL 및 attR의 조합으로 attP 및 attB가 형성된다.
도 10b는 6개의 상이한 att 부위 사이의 서열 차이를 나타내는 것이다. 각 부위는 특이적으로 그의 매치와 재조합된다. attB1 부위는 오직 attP1 부위와만 재조합하게 될 것이며, attB2는 오직 attP2와만 재조합하게 될 것이고, 그 외의 재조합이 이루어질 것이다.
도 11은 A) 재조립을 위해 인간 Ad5 게놈(서열 번호: 137)을 모듈로 나누는 것에 관한 예를 나타낸 것이다. B)는 다중 부위 게이트웨이 기술을 사용하여 제안된 모듈의 재조립 후의 attB 부위 삽입 위치를 나타낸 것이다.
도 12는 인간 Ad5 게놈(서열 번호: 137) 내의 잠재적인 attB 삽입 부위에 관한 예를 나타낸 것이다. 표적화된 영역 내의 다양한 아데노바이러스 서열을 정렬하고, 비보전 서열 주변의 위치를 선택함으로써 삽입 부위가 결정될 수 있다. 화살표 표시가 Ad5에 대해 선택된 부위를 나타낸다. A) E1과 E2 모듈 사이의 attB4 삽입. B) E2와 L3 모듈 사이의 attB6 삽입 부위. C) L3과 E3 모듈 사이의 attB5 삽입. D) E3과 E4 모듈 사이의 attB3 삽입 부위. 이러한 특정한 삽입을 위해, 섬유 폴리A/종결과 E4 폴리A 사이의 Ad5 서열을 중복시킴으로써 재조합 부위를 버퍼링시키기로 결정하였다. 따라서, attB 삽입과 함께 상기 두 요소 사이에 위치하는 27 bp에 대한 중복이 이루어진다.
도 13은 PCR에 의해 5개의 Ad5 모듈을 수득하기 위해 시도하는 것에 관한 도전과제 및 결과를 나타낸 것이다. 하단의 표에는 PCR에 의해 수득된 각 단편의 서열 분석 결과 및 공개된 Ad5 서열과의 차이가 열거되어 있다. 모든 오류의 재현성이 100%이기 때문에, 이는 본 발명자가 사용한 주형이 공개된 Ad5 서열과는 상이하며, PCR 정확도가 높다는 것을 제안한다.
도 14는 Ad5 아데노바이러스 유전자 모듈이 정제된 바이러스로부터 직접 수득된 DNA로부터 PCR에 의해 수득될 수 있다는 것을 보여주는 것이다. Ad5 게놈 DNA를 정제된 바이러스로부터 직접 단리시키고, Ad5 모듈 PCR을 위한 주형으로서 사용하였다. 5개의 PCR 모두 성공적이었다. 좌측 패널: 4중으로 E2 및 L3 모듈 PCR. 우측 패널: 2중으로 E1, E3, 및 E4 모듈 PCR. 적색 화살표 표시는 원하는 PCR 생성물을 나타낸다. 우측에서는 원하는 생성물이 매우 뚜렷이 나타났는 바, 화살표 표시를 생략하였다.
도 15는 게이트웨이 BP 반응에서의 Ad5 아데노바이러스 유전자 모듈의 효율을 나타낸 것이다. E1, E2, 및 L3 모듈은 표준 반응에서는 효율적이지 못한 반면, E3 및 E4 모듈은 효율적인 것으로 나타났다.
도 16은 서열 및 결찰 독립 클로닝(SLIC: sequence and ligation independent cloning)에 관한 다이어그램을 나타낸 것이다. 좌측은 단일 단편 SLIC에 대한 것인 반면, 우측은 다중 (9개의) 단편 SLIC의 예를 나타낸 것이다.
도 17은 SLIC를 사용하여 게이트웨이 클로닝 효소를 사용하지 않고 게이트웨이 엔트리 벡터를 생성하는 것에 관해 나타낸 것이다.
도 18은 Ad5 E1 영역이 박테리아에 대하여 중간 정도의 독성을 띤다는 것을 나타내는 것이다. SLIC를 사용하여 Ad5 E1 영역 또는 대조군(lacZ)을 게이트웨이 DONR 벡터 내로 삽입하였다. lacZ 대조군 상의 콜로니들 모두 "정상" 크기였고, lacZ 삽입에 대하여 양성을 띠었다. E1 플레이트 상에서는 "정상" 크기를 가진 콜로니 단 2개만이 출현하였고, 그 둘 모두 E1에 대하여 음성을 띠었다. 그러나, 그보다 작은 수개의 콜로니들도 존재하였는데(화살표 표시), 그들 모두 E1에 대하여 양성을 띠었다. 따라서, Ad5 E1 영역은 박테리아의 성장을 저속화시킨다. 이는 본 발명자들이 게이트웨이 재조합 반응을 이용하여 E1을 삽입하는 데 있어서 문제를 겪게 되는 이유를 설명한다.
도 19는 5개의 모듈 엔트리 벡터로부터 Ad5 게놈을 재조립하기 위한 초기 다중 부위 게이트웨이 전략법을 나타낸 것이다. 먼저, 5개의 엔트리 벡터 중 3개를 스터퍼 벡터와 함께 조합하였다. 이어서, 스터퍼를 제거하여 역선택 카세트를 삽입하였다. 이어서, 최종 2개의 엔트리 벡터를 조합하여 완전한 게놈을 형성하였다. 이러한 특정의 전략법은 E1 모듈 및 크기가 큰 E2 및 L3 모듈과 관련된 독성을 보여주었다.
도 20은 인간 Ad5 Ad셈블리 이중 DEST 벡터 형성에 관한 것이다. E2 및 L3 모듈을 그의 각각의 엔트리 벡터로부터 PCR에 의해 수득하고, SLIC를 사용하여 벡터 골격과 함께 조합한다. 이어서, 모듈 말단에서 공학처리된 독특한 제한 부위로 벡터를 분해시킨 후, SLIC에 의해 모듈 측면 위치에 게이트웨이 역선택 카세트를 삽입한다.
도 21은 인간 Ad5에 대한 Ad셈블리 과정을 나타낸 것이다. 게이트웨이 LR 반응에서 코어 모듈 이중 DEST 벡터를 남은 3개의 엔트리 벡터 각각 하나씩과 함께 조합하여 완전한 바이러스 게놈를 재조립한다.
도 22는 Ad셈블리 방법으로 시도된 수개의 역선택 마커의 효율을 나타낸 것이다. PheS+ccdB를 사용하였고, 콜로니의 블라인드 스크린에 의해, 또는 먼저 콜로니 PCR을 사용하여 삽입을 확인한 후, 표준 제한 분해 스크리닝에 의해 수행하였을 때 효율적인 것으로 나타났다.
도 23은 Ad셈블리 벡터 골격이 본 방법의 실시양태에 대한 2가지 독특한 특징을 포함한다는 것을 보여주는 것이다. 벡터 골격은 p15A 복제 기점을 사용하는데, 이는 플라스미드의 카피수를 낮춰주며, 이로써, Ad5 E1 모듈에 의해 매개되는 독성은 감소하게 된다. 추가로, 벡터는 포유동물 I-SceI 발현 카세트를 함유하는데, 이를 통해 형질감염시 바이러스 게놈을 벡터 골격으로부터 자가 절제시킬 수 있다.
도 24는 Ad셈블리 반응의 효율을 보여주는 것이다. A) 20 fmol의 코어 이중 DEST 벡터 및 각각의 E1 모듈, E3 모듈, 및 E4 모듈 엔트리 벡터 10 fmol씩을 사용하여 Ad5에 대한 Ad셈블리 반응을 수행하였다. 상기 반응을 실온에서 밤새도록 수행하고, 그 다음날 NEB10-β 세포로 형질전환시켰다. EcoRV 분해에 의한 스크리닝을 위해 16개의 클론을 성장시키고, 제조하였다. 16개의 클론 중 2개가 정확한 제한 분해 패턴(별표 표시, 클론 4 및 8)을 보였다. "L"은 DNA 래더이다. "(-)"는 자체적으로 분해된 코어 이중 DEST 벡터인 음성 대조군이다. "(+)"는 분해된 완전한 Ad5 게놈인 양성 대조군이다. B) E1 엔트리 벡터 양 증가가 Ad셈블리 효율을 개선시킨다는 것을 보여주는 것이다. 20 fmol의 코어 이중 DEST 벡터, 50 fmol의 E1 모듈 엔트리 벡터 및 각각의 E3, 및 E4 모듈 엔트리 벡터 10 fmol씩을 사용하여 Ad5에 대한 Ad셈블리 반응을 수행하였다. 상기 반응을 실온에서 밤새도록 수행하고, 그 다음날 NEB10-β 세포로 형질전환시켰다. EcoRV 분해에 의한 스크리닝을 위해 10개의 클론을 성장시키고, 제조하였다. 10개의 클론 중 7개가 정확한 제한 분해 패턴(적색 별표 표시)을 보였다. "L"은 DNA 래더이다. "(-)"는 분해된 Ad5 E2-E4 벡터인 음성 대조군이다. "(+)"는 분해된 완전한 Ad5 게놈인 양성 대조군이다.
도 25는 인간 Ad5에 대한 AdSlicR 방법을 보여주는 것이다. 우선, Ad셈블리를 위해 생성된 E2-L3 코어 모듈을 시작으로 하여, SwaI 분해에 의해 벡터를 선형화시킨다. 이어서, SLIC를 사용하여 E3 및 E4 모듈을 상기 벡터 내로 삽입한다. 후속 벡터를 PacI로 선형화시킨 후, SLIC에 의해 E1 모듈을 삽입함으로써 완전한 게놈을 형성한다.
도 26은 인간 Ad5 AdSlicR 방법의 효율을 나타낸 것이다. 콜로니 PCR을 제1선 스크리닝으로서 사용한 후, 이어서, PCR 양성 클론의 제한 분해를 수행하였다.
도 27은 Ad셈블링된 바이러스가 조직 배양물 중에서 성장하였다는 것을 보여주는 것이다. A) Ad셈블리에 의해 조립된 복제 아데노바이러스에 의해 생성된 플라크. Ad셈블링된 게놈을 293 세포에 형질감염시키고, 7일째까지 뚜렷한 플라크가 나타났다. B) Ad셈블링된 Ad5를 계대접종하고, 계속 성장시켰다. Ad셈블링된 Ad5의 형질감염으로부터 전체 바이러스를 수집하고, 새로운 293 세포에 다시 플레이팅하였다. 3일째까지 전체 플레이트 전역에 걸쳐 뚜렷한 세포 변성 효과가 시각적으로 나타났다.
도 28은 293 세포에서 성장시켰을 때 Ad셈블링된 Ad5의 역가는 단지 약간 감소하였다는 것을 보여주는 것이다. 293 세포를 야생형 Ad5, Ad셈블링된 Ad5, 또는 attB 삽입을 함유하지 않거나, 또는 4개의 attB 삽입들 각각을 개별적으로 함유하는 AdSLIC Ad5를 이용하여 MOI=10으로 감염시켰다. 48시간 경과 후 전체 바이러스를 수집하고, ELISA에 의해 역가를 측정하였다. 임의의 결함을 보이는 유일의 바이러스는 Ad셈블링된 바이러스 및 attB3 삽입만을 함유하는 AdSLIC 바이러스였다. 상기 둘은 모두 야생형 수준과 비교하였을 때 중간 정도의 2배 감소를 나타내었다. 상기 데이터는 또한 AdSLIC를 사용하여 생성된 바이러스는 293 세포에서 어떤 복제 결함도 가지고 있지 않음을 입증한다. 모든 바이러스에 대한 입력 수준을 적정하였고, 이는 대략 1e7 IU/mL(제시하지 않음)에 가까웠다.
도 29. 도 29A에는 본원에 기술된 Ad셈블리 엔트리 벡터 라이브러리 중의 벡터가 기술되어 있다. 모듈이 유래된 Ad 혈청형이 먼저 열거되어 있고, 이어서, 벡터에 대한 임의의 변이가 열거되어 있다. 어떤 변이도 없다면, 엔트리는 "야생형"으로 언급된다. 도 29B에는 본원에 기술된 Ad셈블리 및 AdSLIC에 대한 마크로모듈 벡터가 기술되어 있다. 마크로모듈이 유래된 Ad 혈청형이 먼저 열거되어 있고, 이어서, 마크로모듈을 포함하는 모듈, 이어서, 벡터에 대한 임의의 변이가 열거되어 있다. 어떤 변이도 없다면, 이는 "야생형"으로 언급된다. 도 29C에는 본원에 기술된 Ad셈블리 또는 AdSLIC를 사용하여 조립된 아데노바이러스 게놈이 기술되어 있다. 게놈의 기초가 되는 Ad 혈청형이 먼저 열거되어 있고, 이어서, 벡터에 대한 임의의 변이가 열거되어 있다. 어떤 변이도 없다면, 이는 "야생형"으로 언급된다.
도 30은 SLIC를 사용하여 전체 게놈을 플라스미드로 삽입하는 것에 관해 나타낸 것이다. A)는 방법을 개략적으로 나타낸 것으로서, 상기 방법을 통해 삽입시키고자 하는 바이러스 게놈의 말단에 대해 상동성인 단쇄부(~20 bp)를 함유하는 플라스미드 벡터를 PCR에 의해 수득하였다. 이어서, 게놈 및 벡터 둘 모두를 T4 DNA 폴리머라제로 처리하고, 일반 방식으로 SLIC에 사용하였다. B)는 전체 Ad5 게놈을 플라스미드 골격 내로 삽입하는 것에 관한 일례를 나타낸 것이다. 스크리닝된 6개의 클론 모두 전체 게놈을 함유하였다. 게놈은 정방향 또는 역방향으로 삽입될 수 있기 때문에, 이러한 경우, 4개는 한 방향으로(클론 1, 4, 5, 및 6), 2개는 다른 방향으로(클론 2 및 3) 위치하였다.
도 31-33은 아데노바이러스 게놈 변형 방법을 도시한 것이다.
도 34의 상단 패널은 AdSLICr 시스템을 사용한 비인간 아데노바이러스인 마우스 아데노바이러스 1형(서열 번호: 104)의 게놈 조립에 관한 예이다. (SwaI 또는 PmeI로) 선형화된 코어 벡터로 서열 및 결찰 독립 클로닝(SLIC)하는 데 필요한 정확한 오버행이 남게 하는 제한 효소로 절제될 수 있도록 E1, E3-섬유, 및 E4 모듈 플라스미드를 디자인하였다. SLIC하는 데 필요한 선형 단편을 수득하기 위해서는 PCR을 수행할 필요가 없으며, 이에 오류가 도입될 잠재성은 삭제된다. 또한 어떤 외래 서열도 최종 게놈 구성체 내로 삽입되지 못하도록 디자인한다. 전형적인 방법은 E3-섬유 및 E4 모듈을 절제하고, PmeI로 선형화된 코어 벡터와 조합하는 것을 포함한다. 이를 통해 E2-E4 마크로모듈이 생성되고, 이어서, 이를 SwaI로 절단하고, 절제된 E1 모듈과 함께 조합함으로써 완전한 게놈이 생성될 수 있다. 하단 패널: 상기 전략법을 사용하여 야생형 마우스 아데노바이러스 1형을 조립하고, 마우스 3T6 세포 형질감염 후, 감염성 바이러스 형성 플라크를 수득하였다.
도 35는 성장을 방해하는 삽입 부위를 확인하기 위해 수행된, 단일 attB 재조합 부위 삽입을 함유하는 바이러스에 관한 성장 분석을 나타내는 것이다. Ad셈블리를 사용하여 생성된 바이러스는 야생형 바이러스와 비교하였을 때, 약간의 성장 결함을 보유하였는 바(도 28), Ad셈블리를 사용하여 생성된 바이러스에 존재하는 각각의 attB 삽입 중 단 하나씩만을 함유하도록 AdSLIC를 사용하여 바이러스를 생성하였다. 293 세포(상단의 그래프)를 MOI=10으로 감염시켰다. U20S 세포(하단의 그래프)는 MOI=50으로 감염시켰다. 48시간 경과 후 전체 바이러스를 수집하고, 역가를 측정하였다. U20S 세포에서의 야생형 바이러스와 비교하였을 때, 모듈 [L3]과 [E3] 사이의 attB5 삽입은 성장을 방해하지 않은 반면, 다른 나머지 3개의 접합부에서의 attB 삽입은 야생형과 비교하였을 때, 성장을 억제시키는 것으로 나타났다.
도 36은 E1과 E2-L2 모듈 사이의 초기 attB4 삽입 부위가 성장 결함을 일으키는 바(도 35), 대체 배치 옵션을 디자인하였다는 것을 보여준다. 염기쌍 위치는 서열 번호: 137에 기재된 위치를 나타낸다.
도 37은 E3과 E4 모듈 사이의 초기 attB4 삽입 부위가 성장 결함을 일으키는 바(도 35), 대체 배치를 디자인하였다는 것을 보여준다. 염기쌍 위치는 서열 번호: 137에 기재된 위치를 나타낸다.
도 38은 U20S 세포를 바이러스를 이용하여 MOI=50으로 감염시키고, 48시간 경과 후 전체 바이러스를 수집하고, 역가를 측정하여 얻은 결과를 나타낸 것이다. Ad셈블리를 사용하여 생성된 3가지 바이러스를 야생형 바이러스와 비교하였다. 대체 attB 부위 삽입(검은색 다이아몬드 표시 및 삼각형 표시)을 함유하는 바이러스는 원래의 attB 부위 배치(검은색 X 표시)와 비교하였을 때, 성장을 개선시켰다. 상기의 모든 바이러스는 L2와 L3 모듈 사이에 위치하는 attB 부위를 포함하지 않고, 성장에 영향을 미치지 않는 L3과 E3 모듈 사이에 attB 삽입을 함유한다.
도 39은 Ad셈블리를 사용하여 트랜스진이 E1 모듈로부터 발현되는 바이러스를 생성할 수 있다는 것을 보여주는 것이다. 이러한 경우, Ad5의 E1A 및 E1B 유전자는 E1 모듈 중 GFP 발현 카세트로 치환되었다. Ad셈블리를 사용하여 바이러스를 조립하고, 생존가능한 GFP 발현 바이러스를 수득하였다.
도 40은 Ad셈블리를 사용하여 트랜스진이 천연 바이러스 전사 구조를 사용하여 E3 모듈로부터 발현되는 바이러스를 생성할 수 있다는 것을 보여주는 것이다. E3 모듈을 변형시켜 11.6 K 단백질(Ad5 뉴클레오티드 29491-29772)을 결실시키고, 그 위치에 mCherry를 배치시켰다. 이어서, E3 전사체는 천연적으로 mCherry 유전자로 스플라이싱되고, 단백질이 발현된다. Ad셈블리를 사용하여 바이러스를 생성하고, U20S 세포의 형질도입을 제시한다. 이는 1) E3 모듈로부터의 트랜스진 발현, 및 2) 천연 바이러스 전사 구조를 사용하여 외래 유전자를 발현시키는 것에 관한 예이다.
도 41은 천연 바이러스 전사 구조를 사용하여 E4 모듈로부터 다중 트랜스진을 발현하는 것을 보여주는 것이다. 천연 E4 프로모터를 CMV 프로모터로 치환하고, 3개의 천연 E4 유전자를 트랜스진으로 치환하였다. 이어서, Ad셈블리를 사용하여 바이러스를 생성하였다. 염기쌍 위치는 서열 번호: 137에 기재된 위치를 나타낸다.
도 42는 Ad셈블리를 사용하여 다중 트랜스진이 천연 바이러스 전사 구조를 사용하여 E4 모듈로부터 발현되는 바이러스를 생성할 수 있다는 것을 보여주는 것이다. 도 41에서 생성된 바이러스를 24 hr 동안 U20S 세포로 형질도입시키고, 전체 RNA를 수집하고, 무작위 프라이밍을 사용하여 RNA로부터 cDNA를 합성하고, PCR을 수행하여 mCherry 유전자에 대한 스플라이싱에 대해 테스트하였다. 검은색 화살표 표시는 GFP를 발현하게 되는 스플라이싱되지 않은 전사체를 나타낸다. 흰색 화살표 표시는 mCherry를 발현하게 되는 스플라이싱된 전사체를 나타낸다. 이는 다중 외래 유전자가 단일 모듈로부터 발현될 수 있다는 것을 입증한다. 레인 1 및 2는 각각 형질도입되지 않은 세포의 음성 대조군 또는 야생형 Ad5로 감염된 세포이다.
도 43은 Ad셈블리를 사용하여 이루어진 단일 게놈 조립체 중 다중 모듈 간의 다중 유형의 변이 도입을 나타낸 것이다. Ad5 게놈의 5개의 모듈을 나타내는 다이어그램으로, 여기서, 수직 화살표 표시는 전체 게놈 조립 이전에 각 모듈에 대해 이루어진 변이를 나타내는 것이다. E1 모듈을 루시퍼라제-GFP 융합 단백질에 대한 트랜스진 발현 카세트로 전환시켰다. L3 모듈 중 헥손 단백질을 점 돌연변이에 의해 Glu 451에서 Gln으로 변경시켰다. E3 모듈 중 천연 Ad5 섬유 부분은 다른 인간 아데노바이러스 혈청형으로부터의 수개의 섬유 부분 중 하나로 치환하였다. Ad셈블리를 사용하여, 각각이 대체 섬유 단백질을 포함하는 것인 6개의 바이러스를 생성하였다. Ad5에 대해 열거된 염기쌍 위치는 서열 번호: 137에 기재된 위치를 나타낸다. 수탁 번호 DQ086466, AJ854486, BK001453, NC_001460, 및 AY_737797은 각각 서열 번호: 139-143에 상응한다.
도 44는 Ad셈블리를 사용하여 생성된 섬유 키메라 바이러스를 통해 인간 배아 줄기 세포(hESC: human embryonic stem cell)에서의 형질도입 능력이 일반 Ad5 섬유와 비교하였을 때 개선되었다는 것을 나타내는 것이다. 24 또는 48시간 동안 인간 ESC를 다양한 MOI로 형질도입시키고, GFP 발현에 대해 현미경으로 측정하였다. 상단 패널은 바이러스를 포함하지 않는 음성 대조군이다. 두번째 패널은 "Ad5 CMV-GFP"로서, 이는 CMV 프로모터하에 GFP를 발현하는 것이다. 테스트된 바이러스 섬유 키메라는 좌측에 명시되어 있다(즉, Ad5/3은 Ad3 섬유 놉을 포함하는 Ad5이다). 모든 영상은 5X 확대 배율로 촬영된 것이다.
도 45는 아데노바이러스 혈청형 간의 코어 모듈 교환을 통해 생존가능한 바이러스가 생산된다는 것을 보여주는 것이다. Ad11로부터의 코어 모듈을 생성하였다. 각각 Ad11 pIX 및 U 엑손-섬유를 보유하도록 Ad5 E1 및 E3 모듈을 변형시켰다. AdSLIC를 사용하여 전체 바이러스를 조립하고, 293 세포 상에서 바이러스를 재구성하였다. "최종 바이러스" 목록에 기록되어 있는 염기쌍 위치는 서열 번호: 137(Ad5) 및 서열 번호: 141(Ad11)에 기재되어 있는 것으로부터의 것이다.
도 46은 바이러스 감염과 관련하여 바이러스의 작용 연구를 위해 바이러스 유전자를 돌연변이시키기 위해 AdSLIC를 사용하는 것을 보여주는 것이다. E1 모듈에서, E1B-55K 유전자를 His 260 위치에서 Ala로 돌연변이시켰다. 다른 모듈 모두는 야생형이었다. AdSLIC를 사용하여 상기 바이러스를 조립하였다. 인간 소기도 상피 세포를 복제 결함이 있는 Ad5(레인 1), 야생형 Ad5(레인 2), 또는 Ad5 H260A(레인 3)를 이용하여 MOI=10으로 감염시켰다. 감염 후 36시간 경과하였을 때, 전체 단백질을 수집하고, p53(상단 패널), mdm2, Ad5 후기 단백질, 및 액틴에 대한 웨스턴 블롯에 의해 분석하였다. 야생형 Ad5와 달리, Ad5-H260A 바이러스는 p53을 분해하지 못했고, 후기 단백질 생산에 있어서도 결함이 있었다.

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정의

"핵산"이란 단일 또는 이중 가닥 형태의 데옥시리보뉴클레오티드 또는 리보뉴클레오티드 및 그의 중합체, 및 그의 보체를 의미한다. 상기 용어는 참조 핵산과 유사한 결합 특성을 가지고, 참조 뉴클레오티드와 유사한 방식으로 대사 작용하는 것인, 합성, 천연적으로 발생된, 및 비천연적으로 발생된, 공지의 뉴클레오티드 유사체 또는 변형된 골격 잔기 또는 결합을 함유하는 핵산을 포함한다. 그러한 유사체의 예로는 제한없이, 포스포로티오에이트, 포스포라미데이트, 메틸 포스포네이트, 키랄 메틸 포스포네이트, 2-O-메틸 리보뉴클레오티드, 펩티드 핵산(PNA: peptide-nucleic acid)을 포함한다.

달리 명시되지 않는 한, 특정 핵산 서열은 또한 암묵적으로는, 명확하게 명시된 서열 뿐만 아니라, 그의 보존적으로 변형된 변이체(예컨대, 축퇴성 코돈 치환) 및 상보적인 서열을 포함한다. 구체적으로, 축퇴성 코돈 치환은 하나 이상의 선택된(또는 모든) 코돈의 세번째 위치의 것이 혼합형 염기 및/또는 데옥시이노신 잔기로 치환되는 서열을 생성함으로써 달성될 수 있다(문헌 ([Batzer et al., Nucleic Acid Res. 19:5081 (1991)]; [Ohtsuka et al., J. Biol . Chem . 260:2605-2608 (1985)]; [Rossolini et al., Mol . Cell. Probes 8:91-98 (1994))])). 핵산이라는 용어는 유전자, cDNA, mRNA, 올리고뉴클레오티드, 및 폴리뉴클레오티드와 상호교환적으로 사용된다.

특정 핵산 서열은 또한 암묵적으로는 "스플라이스 변이체"를 포함한다. 유사하게, 핵산에 의해 코딩된 특정 단백질은 암묵적으로는 상기 핵산의 스플라이스 변이체에 의해 코딩된 임의의 단백질을 포함한다. "스플라이스 변이체"란 그 명칭이 제안하는 바와 같이, 유전자의 선택적 스플라이싱의 생성물이다. 전사 후, 초기 핵산 전사체는 상이한(대체) 핵산 스플라이스 생성물이 상이한 폴리펩티드를 코딩할 수 있도록 스플라이싱될 수 있다. 스플라이스 변이체를 제조하는 기전은 다양하지만, 엑손의 선택적 스플라이싱을 포함한다. 연속 판독 전사에 의해 동일의 핵산으로부터 유도된 대체 폴리펩티드 또한 상기 정의에 포함된다. 재조합 형태의 스플라이스 생성물을 비롯한, 스플라이싱 반응의 임의의 생성물이 상기 정의에 포함된다. 칼륨 채널 스플라이스 변이체의 예는 문헌 [Leicher, et al., J. Biol . Chem . 273(52):35095-35101 (1998)]에서 논의된 바 있다.

*원하는 치료학적 유전자 코딩 및 제어 서열을 함유하는 적합한 벡터 구성은 당업계에서 잘 이해되고 있는 표준 결찰 및 제한 기법을 사용할 수 있다(문헌 [Maniatis et al., in Molecular Cloning: A Laboratory Manual., Cold Spring Harbor Laboratory, New York (1982)] 참조). 단리된 플라스미드, DNA 서열, 또는 합성된 올리고뉴클레오티드는 원하는 형태로 절단, 테일러링(tailor), 및 재결찰될 수 있다.

핵산이 또 다른 핵산 서열과 작용상 관련이 있도록 배치될 때, 이는 "작동가능하게 연결된다." 예를 들어, 전서열 또는 분비 리더에 대한 DNA는 폴리펩티드의 분비에 참여하는 전단백질로서 발현될 경우, 폴리펩티드에 대한 DNA에 작동가능하게 연결되거나; 프로모터 또는 인핸서는 코딩 서열의 전사에 영향에 미칠 경우, 상기 서열에 작동가능하게 연결되거나; 또는 리보솜 결합 부위는 번역이 원활하게 일어날 수 있도록 하기 위해 배치될 경우, 코딩 서열에 작동가능하게 연결된다. 일반적으로, "작동가능하게 연결"이라는 것은 연결되는 DNA 서열이 서로 가깝게 위치하고, 분비 리더의 경우에는 인접하여 위치하며, 판독 단계에 있다는 것을 의미한다. 그러나, 인핸서는 인접하여 위치할 필요는 없다. 연결은 편리한 제한 부위에서의 결찰에 의해 달성된다. 상기 부위가 존재하지 않을 경우, 종래 수행 방법에 따라 합성 올리고뉴클레오티드 어댑터 또는 링커가 사용된다.

2종 이상의 핵산 또는 폴리펩티드 서열과 관련하여 "동일한" 또는 "동일성(%)"이라는 용어는 하기 기술되는 디폴트 파라미터와 함께 BLAST 또는 BLAST 2.0 서열 비교 알고리즘을 사용함으로써, 또는 수동 정렬 및 시각적 검사(예컨대, NCBI 웹사이트 등 참조)에 의해 측정된 바, 동일하거나, 동일한 아미노산 잔기 또는 뉴클레오티드를 명시된 비율(%)로 포함하는 것인(즉, 비교창 또는 지정된 영역에 걸쳐 최대한 상응하도록 정렬되고, 그를 비교하였을 때, 명시된 영역에 대해 약 60%의 동일성, 바람직하게 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 이상의 동일성을 가지는) 2개 이상의 서열 또는 서브서열을 의미한다. 이어서, 상기 서열은 "실질적으로 동일하다"라고 언급될 수 있다. 상기 정의는 또한 테스트 서열의 보체를 의미하거나, 그에 대해 적용될 수 있다. 상기 정의는 또한 치환을 가지는 서열 뿐만 아니라, 결실 및/또는 부가를 가지는 서열도 포함한다. 하기 기술하는 바와 같이, 바람직한 알고리즘은 갭 등을 설명할 수 있다. 바람직하게, 동일성은 길이가 약 25개 이상의 아미노산 또는 뉴클레오티드인 영역에 대해, 또는 더욱 바람직하게는 길이가 50-100개의 아미노산 또는 뉴클레오티드인 영역에 대해 존재한다.

서열 비교를 위해, 전형적으로는 한 서열이 테스트 서열과 비교되는 참조 서열로서의 역할을 한다. 서열 비교 알고리즘을 사용할 경우, 테스트 서열 및 참조 서열을 컴퓨터에 입력하고, 필요할 경우, 서브서열 좌표를 지정하고, 서열 알고리즘 프로그램 파라미터를 지정한다. 바람직하게, 디폴트 프로그램 파라미터를 사용할 수 있거나, 또는 대체 파라미터를 지정할 수 있다. 이어서, 서열 비교 알고리즘은 프로그램 파라미터에 기초하여 참조 서열과의 비교로 테스트 서열에 대한 서열 동일성(%)을 계산한다.

본원에서 사용되는 바, "비교창"은 두 서열이 최적으로 정렬된 후, 서열이 같은 개수의 인접한 위치로 이루어진 참조 서열과 비교될 수 있는 것인, 20 내지 600개, 일반적으로는 약 50 내지 약 200개, 더욱 일반적으로 약 100 내지 약 150개로 이루어진 군으로부터 선택되는 인접한 위치의 개수 중 어느 하나로 이루어진 세그먼트를 언급하는 것을 포함한다. 비교를 위한 서열 정렬 방법은 당업계에 주지되어 있다. 비교를 위한 서열의 최적의 정렬은 예컨대, 문헌 [Smith & Waterman, Adv . Appl. Math. 2:482 (1981)]의 국소적 상동성 알고리즘에 의해, 문헌 [Needleman & Wunsch, J. Mol . Biol . 48:443 (1970)]의 상동성 정렬 알고리즘에 의해, 문헌 [Pearson & Lipman, Proc. Nat'l. Acad . Sci . USA 85:2444 (1988)]의 유사성 방법에 대한 탐색에 의해, 이들 알고리즘(위스콘신 제네틱스 소프트웨어 패키지(Wisconsin Genetics Software Package, 미국 위스콘신주 매디슨 사이언스 드라이브 575 제네틱스 컴퓨터 그룹)에서 GAP, BESTFIT, FASTA 및 TFASTA)의 컴퓨터화된 이행에 의해, 또는 수동 정렬 및 시각적 검사(예컨대, 문헌 [Current Protocols in Molecular Biology (Ausubel et al., eds. 1995 supplement)] 참조)에 의해 수행될 수 있다.

서열 동일성(%) 및 서열 유사성(%)을 측정하는 데 적합한 알고리즘에 관한 바람직한 예로는 BLAST 및 BLAST 2.0 알고리즘이 있으며, 이는 각각 문헌 ([Altschul et al., Nuc . Acids Res. 25:3389-3402 (1977)] 및 [Altschul et al., J. Mol . Biol . 215:403-410 (1990)])에 기술되어 있다. 본 발명의 핵산 및 단백질에 대한 서열 동일성(%)을 측정하는 데 본원에 기술된 파라미터와 함께 BLAST 및 BLAST 2.0이 사용된다. BLAST 분석 실행용 소프트웨어는 당업계에 공지되어 있는 바와 같이, 미국 국가 생물 공학 센터(National Center for Biotechnology Information)를 통해 공개적으로 이용할 수 있다. 이 알고리즘은 우선 데이터베이스 서열에서 동일한 길이의 워드와 함께 정렬되었을 때, 어느 정도의 양의 값의 역치 점수 T에 매치되거나, 그를 충족시키는 의문 서열에서 길이 W의 짧은 워드를 확인함으로써 고 점수화 서열 쌍(HSP: high scoring sequence pair)을 확인하는 것을 포함한다. T는 근접 워드 점수 역치(문헌 [Altschul et al., 상기 문헌 동일]) 를 나타낸다. 이들 초기 근접 워드 히트는 이들을 함유하는 더 긴 HSP를 찾기 위한 탐색 개시용 시드로서 작용한다. 워드 히트는 누적 정렬 점수가 증가될 수 있는 한, 각각의 서열을 따라서 양 방향으로 연장된다. 누적 점수는 뉴클레오타이드 서열의 경우, 파라미터 M(매칭되는 잔기의 쌍에 대한 보상 점수; 항상 >0) 및 N(미스매칭되는 잔기에 대한 패널티 점수; 항상 <0)을 사용하여 계산된다. 아미노산 서열의 경우, 점수화 매트릭스를 사용하여 누적 점수를 계산한다. 각각의 방향에서 워드 히트의 연장은 누적 정렬 점수가 달성된 그의 최대값으로부터 양 X 만큼 떨어지거나; 누적 점수가 하나 이상의 음의 점수화 잔기 정렬의 누적으로 인하여 0 이하가 되거나; 또는 어느 한 서열의 말단에 도달한 경우에는 중지된다. BLAST 알고리즘 파라미터 W, T 및 X가 정렬의 감도 및 속도를 결정한다. BLASTN 프로그램(뉴클레오타이드 서열의 경우)은 디폴트로서 워드길이(W)=11, 기대치(E)=10, M=5, N=-4 및 두 가닥 모두의 비교를 사용한다. 아미노산 서열의 경우에 BLASTP 프로그램은 디폴트로서 워드길이=3, 및 기대치(E)=10, 및 BLOSUM62 점수화 매트릭스(문헌 [Henikoff & Henikoff, Proc . Natl . Acad . Sci . USA 89: 10915 (1989)]) 정렬(B)=50, 기대치(E)=10, M=5, N=-4 및 두 가닥 모두의 비교를 사용한다.

"폴리펩티드" "펩티드" 및 "단백질"이라는 용어는 본원에서 상호교환적으로 사용되며, 이는 아미노산 잔기의 중합체를 의미한다. 상기 용어는 천연적으로 발생된 아미노산 중합체 및 비천연적으로 발생된 아미노산 중합체 뿐만 아니라, 하나 이상의 아미노산 잔기가 상응하는 천연적으로 발생된 아미노산의 인공 화학적 모방체인 것인 아미노산 중합체에도 적용된다.

"아미노산"이라는 용어는 천연적으로 발생된 및 합성 아미노산 뿐만 아니라, 천연적으로 발생된 아미노산과 유사한 방식으로 작용하는 아미노산 유사체 및 아미노산 모방체도 의미한다. 천연적으로 발생된 아미노산은 유전자 코드에 의해 코딩된 것 뿐만 아니라, 추후에 변형되는 아미노산, 예컨대, 하이드록시프롤린, γ- 카복시글루타메이트, 및 O-포스포세린이다. 아미노산 유사체란 천연적으로 발생된 아미노산과 동일한 기본 화학적 구조를 가지는, 즉, 수소에 결합된 탄소, 카복실기, 아미노기, 및 R 기를 가지는 화합물을 의미하며, 그 예로는 호모세린, 노르류신, 메티오닌 술폭시드, 메티오닌 메틸 술포늄이 있다. 상기와 같은 유사체는 변형된 R 기(예컨대, 노르류신) 또는 변형된 펩티드 골격를 가지지만, 천연적으로 발생된 아미노산과 동일한 기본 화학적 구조를 보유한다. 아미노산 모방체란 아미노산의 일반 화학 구조와는 상이한 구조를 가지지만, 천연적으로 발생된 아미노산과 유사한 방식으로 작용하는 화학 화합물을 의미한다.

본원에서 아미노산은 아미노산에 관해 보편적으로 알려져 있는 3문자 기호로 또는 IUPAC-IUB 생화학 명명법 위원회(IUPAC-IUB Biochemical Nomenclature Commission)에 의해 권고되는 1문자 기호로 나타낼 수 있다. 유사하게, 뉴클레오티드도 뉴클레오티드에 관해 보편적으로 허용되는 1문자 코드로 나타낼 수 있다.

"보존적으로 변형된 변이체"는 아미노산 및 핵산 서열, 둘 모두에 적용된다. 특정 핵산 서열과 관련하여, 보존적으로 변형된 변이체란 동일하거나, 또는 본질적으로 동일한 아미노산 서열을 코딩하는 핵산, 또는 핵산이 아미노산 서열을 코딩하지 않을 경우, 본질적으로 동일한 서열을 의미한다. 유전자 코드의 축퇴성에 기인하여, 다수의 작용성 동일한 핵산이 임의의 주어진 단백질을 코딩한다. 예를 들어, 코돈 GCA, GCC, GCG 및 GCU, 모두가 아미노산 알라닌을 코딩한다. 따라서, 코돈에 의해 알라닌으로 명시되는 모든 위치에서 코돈은 코딩되는 폴리펩티드는 변경시키지 않으면서, 기술된 상응하는 코돈 중 임의의 것으로 변경될 수 있다. 그러한 핵산 변이가 "침묵 변이"인데, 이는 보존적으로 변형된 변이 중의 한 종류이다. 폴리펩티드를 코딩하는 본원의 모든 핵산 서열 또한 핵산의 모든 가능한 침묵 변이를 설명한다. 핵산 중의 각 코돈(단, 보통 메티오닌에 대한 유일의 코돈인 AUG, 및 보통 트립토판에 대한 유일의 코돈인 TGG 제외)을 변형시킴으로써 작용상 동일한 분자를 수득할 수 있다는 것을 당업자는 이해할 것이다. 따라서, 폴리펩티드를 코딩하는 핵산의 각 침묵 변이는 실제 프로브 서열과는 상관없이, 발현 생성물과 관련하여 각 기술된 서열에 내재되어 있다.

아미노산 서열과 관련하여 코딩된 서열에서 단일 아미노산 또는 작은 비율의 아미노산을 변경, 부가, 또는 결실시키는, 핵산, 펩티드, 폴리펩티드, 또는 단백질 서열에 대한 개별 치환, 결실 또는 부가는, 변경으로 인해 아미노산이 화학적으로 유사한 아미노산으로 치환되는 "보존적으로 변형된 변이체"라는 것을 당업자는 이해할 것이다. 작용상 유사한 아미노산을 제공하는 보존적 치환 표는 당업계에 주지되어 있다. 그러한 보존적으로 변형된 변이체는 추가로 본 발명의 다형태 변이체, 종간 상동체, 및 대립유전자를 포함하며, 배제시키지 않는다.

하기 8개의 군은 각각 서로 보존적 치환을 하는 아미노산을 포함한다: 1) 알라닌(A), 글리신(G); 2) 아스파르트산(D), 글루탐산(E); 3) 아스파라긴(N), 글루타민(Q); 4) 아르기닌(R), 리신(K); 5) 이소류신(I), 류신(L), 메티오닌(M), 발린(V); 6) 페닐알라닌(F), 티로신(Y), 트립토판(W); 7) 세린(S), 트레오닌(T); 및 8) 시스테인(C), 메티오닌(M)(예컨대, 문헌 [Creighton, Proteins (1984)] 참조).

예컨대, 세포, 바이러스, 핵산, 단백질, 또는 벡터와 관련하여 사용될 때, "재조합"이라는 용어는 세포, 바이러스, 핵산, 단백질 또는 벡터가 이종성 핵산 또는 단백질의 도입에 의해, 또는 천연 핵산 또는 단백질의 변경에 의해 변형되었거나, 또는 세포가 그렇게 변형된 세포로부터 유래된 것이라는 것을 의미하는 것이다. 따라서, 예를 들어, 재조합 세포는 천연(비재조합) 형태의 세포내에서는 발견되지 않는 유전자를 발현하거나, 또는 발현시에 다르게 비정상적으로 발현되거나, 전혀 발현되지 않는 천연 유전자를 발현한다.

"엄격한 하이브리드화 조건"이라는 어구는 프로브가 전형적으로는 핵산의 복합 혼합물 중에서 다른 서열에는 하이브리드화하지 않지만, 그의 표적 서브서열에는 하이브리드화하게 되는 상태의 조건을 의미한다. 엄격한 조건은 서열에 의존하며, 이는 다른 환경하에서는 달라지게 될 것이다. 보다 장쇄인 서열은 보다 고온인 온도에서 특이적으로 하이브리드화한다. 핵산의 하이브리드화에 관한 광범위한 가이드는 [Tijssen, Techniques in Biochemistry and Molecular Biology- Hybridization with Nucleic Probes, "Overview of principles of hybridization and the 전략법 of nucleic acid assays" (1993)]에서 살펴볼 수 있다. 일반적으로, 엄격한 조건은 정의된 이온 강도, pH에서 특정 서열에 대한 열적 융점(T_m: thermal melting point)보다 약 5-10℃ 정도 낮은 온도가 되도록 선택된다. T_m은 (표적 서열은 과량으로 존재하는 바, T_m에서 프로브의 50%가 평형 상태로 점유되기 때문에) 표적에 상보적인 프로브 중 50%가 평형 상태로 표적 서열에 하이브리드화하게 되는 (정의된 이온 강도, pH 및 핵산 농도하의) 온도이다. 엄격한 조건은 또한, 탈안정화제, 예컨대, 포름아미드를 첨가함으로써 달성될 수 있다. 선택적 또는 특이적 하이브리드화를 위해, 양의 신호는 배경의 2배 이상, 바람직하게는 배경 하이브리드화의 10배인 것이다. 예시적인 엄격한 하이브리드화 조건은 하기와 같다:50%> 포름아미드, 5x SSC, 및 1% SDS, 42℃에서 인큐베이션, 또는 5x SSC, 1% SDS, 65℃에서 인큐베이션, 0.2x SSC 중에서, 및 65℃에서 0.1% SDS 중에서 세척.

엄격한 조건하에서 서로 하이브리드화하지 않는 핵산은, 그들이 코딩하는 폴리펩티드가 실질적으로는 동일할 경우, 이는 여전히 실질적으로는 동일한 것이다. 이같은 것은 예를 들어, 유전자 코드에 의해 허용되는 최대의 코돈 축퇴성을 사용하여 핵산 카피가 생성되었을 경우에 발생한다. 상기 경우에 핵산은 전형적으로는 중간 정도의 엄격한 하이브리드화 조건하에서 하이브리드화하게 된다. 예시적인 "중간 정도의 엄격한 하이브리드화 조건"은 37℃에서 40% 포름아미드의 버퍼, 1 M NaCl, 1% SDS 중에서의 하이브리드화, 및 45℃에서 1X SSC 중에서 세척을 포함한다. 양의 하이브리드화는 배경의 2배 이상인 것이다. 대체 하이브리드화 및 세척 조건을 사용하여 유사의 엄격한 조건을 제공할 수 있다는 것을 당업계의 숙련가는 쉽게 이해할 수 있을 것이다. 하이브리드화 파라미터를 결정짓는 추가의 가이드라인은 예컨대, 문헌 [Current Protocols in Molecular Biology, ed. Ausubel, et al., John Wiley & Sons]과 같은, 많은 참고 문헌에 제공되어 있다.

PCR을 위해서는, 비록 어닐링 온도는 프라이머의 길이에 따라 약 32℃ 내지 48℃로 달라질 수 있지만, 낮은 엄격도의 증폭을 위해서는 약 36℃인 온도가 전형적인 온도이다. 높은 엄격도의 PCR 증폭을 위해서는, 비록 높은 엄격도의 어닐링 온도는 프라이머의 길이 및 특이성에 따라 약 50℃ 내지 약 65℃로 달라질 수 있지만, 약 62℃인 온도가 전형적인 온도이다. 높은 엄격도 및 낮은 엄격도의 증폭, 둘 모두를 위해 전형적인 사이클 조건으로는 90℃-95℃에서 30초-2분. 동안의 변성 단계, 30초-2분. 동안 지속되는 어닐링 단계, 및 약 72℃에서 1-2분. 동안의 신장 단계를 포함한다. 낮은 엄격도 및 높은 엄격도의 증포 반응을 위한 프로토콜 및 가이드라인은 예컨대, 문헌 [Innis et al. (1990) PCR Protocols, A Guide to Methods and Applications, Academic Press, Inc. N.Y.)]에 제공되어 있다.

본원에서 사용되는 바, "암"이라는 용어는 백혈병, 암종 및 육종을 비롯한, 포유동물에서 발견되는 모든 유형의 암, 신생물, 또는 악성 종양을 의미한다. 암의 예로는 뇌암, 유방암, 자궁경부암, 결장암, 두부경부암, 간암, 신장암, 폐암, 비소세포 폐암, 흑색종, 중피종, 난소암, 육종, 위암, 자궁암 및 수모세포종을 포함한다. 추가의 예로는 호지킨병, 비호지킨 림프종, 다발골수종, 신경아세포종, 난소암, 횡문근육종, 원발성 혈소판증가증, 원발성 마크로글로불린혈증, 원발성 뇌 종양, 암, 악성 췌장 인슐린종, 악성 카르시노이드, 방광암, 전암성 피부 병소, 고환암, 림프종, 갑상샘암, 신경아세포종, 식도암, 비뇨생식관암, 악성 고칼슘혈증, 자궁내막암, 부신피질암, 내분비 및 외분비 췌장의 신생물, 및 전립샘암을 포함한다.

"백혈병"이라는 용어는 광범위하게는 혈액 형성 기관의 진행성 악성 질환을 의미하는 것으로, 이는 일반적으로 혈액 및 골수 중 백혈구 및 그의 전구체의 기형적 증식 및 발생을 특징으로 한다. 백혈병은 일반적으로는 임상적으로 (1) 질환의 지속 기간 및 특징-급성 또는 만성; (2) 관여하는 세포 유형; 골수(골수성), 림프계(림프성), 또는 단핵구성; 및 (3) 혈액 중 비정상적인 세포의 개수 증가 또는 비증가-백혈성 또는 무백혈성(아백혈성)을 기초로 분류된다. P₃₈₈ 백혈병 모델은 생체내 항백혈병 활성을 예측하는 것으로 광범위하게 허용되고 있다. P₃₈₈ 검정에서 양성인 것으로 테스트된 화합물이 일반적으로는 치료하고자 하는 백혈병 유형과는 상관없이 생체내에서 어느 정도 수준의 항백혈병 활성을 보이는 것으로 여겨진다. 따라서, 본 발명은 백혈병을 치료하는 방법, 및 바람직하게는, 급성 비림프구성 백혈병, 무백혈성성 림프구성 백혈병, 급성 과립구성 백혈병, 무백혈성성 과립구성 백혈병, 급성 전골수구성 백혈병, 성인 T-세포 백혈병, 무백혈성 백혈병, 백혈구 증가 백혈병, 호염기구성 백혈병, 아세포 백혈병, 소 백혈병, 무백혈성성 골수구성 백혈병, 피부 백혈병, 배아성 백혈병, 호산구성 백혈병, 그로스(Gross) 백혈병, 모세포 백혈병, 혈아세포 백혈병, 혈구아세포 백혈병, 조직구성 백혈병, 줄기 세포 백혈병, 급성 단핵구성 백혈병, 백혈구감소 백혈병, 림프성 백혈병, 림프아구성 백혈병, 림프구성 백혈병, 림프성 백혈병, 림프계 백혈병, 림프육종 세포 백혈병, 비만 세포 백혈병, 거핵구 백혈병, 소골수아구성 백혈병, 단핵구성 백혈병, 골수아구성 백혈병, 골수구성 백혈병, 골수 과립구성 백혈병, 골수단핵구성 백혈병, 네겔리(Naegeli) 백혈병, 형질 세포 백혈병, 다중 골수종, 형질 세포성 백혈병, 전골수구성 백혈병, 라이더(Rieder) 세포 백혈병, 쉴링(Schilling's) 백혈병, 줄기 세포 백혈병, 아백혈성 백혈병, 및 미분화성 세포 백혈병을 치료하는 방법을 포함한다.

"육종"이라는 용어는 일반적으로 배아 결합 조직과 같은 물질로 구성되고, 일반적드로는 섬유원성 또는 균질 물질에 포매되어 있는 빽빽하게 밀집되어 있는 세포로 이루어진 종양을 의미한다. 항신생물성 티올 결합 미토콘드리아 산화제 및 암제의 조합물로 치료될 수 있는 육종으로는 연골육종, 섬유육종, 림프육종, 흑색육종, 점액육종, 골육종, 아베메티(Abemethy's) 육종, 지방성 육종, 지방육종, 포상연부 육종, 법랑아 육종, 포도형 육종, 녹색종 육종, 육모 암종, 배아성 육종, 윌름즈(Wilms') 종양 육종, 자궁내막 육종, 간질 육종, 유잉 육종, 근막 육종, 섬유아세포 육종, 거대 세포 육종, 과립구성 육종, 호지킨 육종, 특발성 다중 색소침착성 출혈 육종, B 세포의 면역아세포 육종, 림프종, T 세포의 면역아세포 육종, 엔센(Jensen's) 육종, 카포시 육종, 쿠퍼(Kupffer) 세포 육종, 혈관육종, 백혈육종, 악성 중간엽종 육종, 방골성 육종, 망상적혈구 육종, 라우스 육종, 장액낭종 육종, 활액 육종, 및 모세혈관확장 육종을 포함한다.

"흑색종"이라는 용어는 피부 및 다른 기관의 멜라닌세포계로부터 유발된 종양을 의미한다. 항신생물성 티올 결합 미토콘드리아 산화제 및 암제의 조합물로 치료될 수 있는 흑색종으로는 예를 들어, 말단흑자 흑색종, 무멜라닌 흑색종, 양성 연소성 흑색종, 클라우드맨즈(Cloudman's) 흑색종, S91 흑색종, 하딩-패세이(Harding-Passey) 흑색종, 연소성 흑색종, 악성 흑점자 흑색종, 악성 흑색종, 결절성 흑색종, 조갑하 흑색종, 및 표재성 확산 흑색종을 포함한다.

"암종"이라는 용어는 주변 조직으로 침윤되고, 전이를 일으키는 경향을 지닌 상피 세포로 구성된 악성 신생 성장을 의미한다. 항신생물성 티올 결합 미토콘드리아 산화제 및 암제의 조합물로 치료될 수 있는 암종의 예로는 예를 들어, 세엽 세포 암종, 선방상 암종, 선낭 암종, 선양 낭성 암종, 선 암종, 부신 피질 암종, 폐포 암종, 폐포 세포 암종, 기저 세포 암종, 기저 세포성 암종, 기저양 암종, 기저 편평 세포 암종, 기관지폐포 암종, 세기관지 암종, 기관지원성 암종, 대뇌양 암종, 담관세포 암종, 융모막 암종, 콜로이드 암종, 면포 암종, 자궁체부 암종, 사상 암종, 갑옷암종, 피부 암종, 원주상 암종, 원주상 세포 암종, 관암종, 경성 암종, 배아성 암종, 뇌질양 암종, 표피양 암종, 상피 선양 암종, 외성장 암종, 궤양성 암종, 섬유성, 젤라틴모양 암종, 젤라틴 암종, 거대 세포 암종, 거대 세포성 암종, 선암종, 과립막 세포 암종, 모기질 암종, 헤마토이드 암종, 간세포 암종, 휘르틀레(Hurthle) 세포 암종, 유리질 암종, 유부신종, 영아 배아성 암종, 계내 암종, 표피내 암종, 상피내 암종, 크롬페셔즈(Krompecher's) 암종, 쿨치스키(Kulchitzky) 세포 암종, 대세포 암종, 수정체 암종, 수정체양 암종, 지방종성 암종, 림프상피 암종, 속질 암종, 수질성 암종, 멜라닌성 암종, 연성 암종, 점액 암종, 점액분비성 암종, 점액세포성 암종, 점막표피양 암종, 점액 암종, 점액성 암종, 점액종성 암종, 코인두 암종, 귀리 세포 암종, 골화 암종, 유골 암종, 유두상 암종, 문맥주위 암종, 침습전 암종, 가시 세포 암종, 풀 모양 암종, 신장의 신장 세포 암종, 예비 세포 암종, 육종성 암종, 시나이더 암종, 경화성 암종, 음낭암종, 반지 세포 암종, 단순 암종, 소세포 암종, 솔라노이드 암종, 구형 세포 암종, 방추 세포 암종, 해면 암종, 편평 암종, 편평 세포 암종, 선상 암종, 모세혈관확장 암종, 모세혈관확장성 암종, 이행 세포 암종, 결절성 암종, 결절 암종, 사마귀 모양 암종, 및 유모 암종을 포함한다.

본원에서 "치료학상 유효 용량 또는 유효량"이란 효과를 일으킬 수 있는 투여 용량을 의미한다. 정확한 용량 및 제제는 치료 목적에 따라 달라질 것이며, 공지된 기법을 사용함으로써 당업자에 의해 확인될 것이다(문헌, ([Lieberman, Pharmaceutical Dosage Forms (vols. 1-3, 1992)]; [Lloyd, The Art, Science and Technology of Pharmaceutical Compounding (1999)]; [Remington: The Science and Practice of Pharmacy, 20th Edition, Gennaro, Editor (2003)], 및 [Pickar, Dosage Calculations (1999)]) 참조).

"약학적으로 허용가능한 염" 또는 "약학적으로 허용가능한 담체"라는 용어는 본원에 기술된 화합물 상에서 발견되는 특정 치환기에 따라, 상대적으로 비독성인 산 또는 염기를 사용하여 제조된 활성 화합물의 염을 포함한다는 것을 의미한다. 본 발명의 화합물이 상대적으로 산성을 띠는 관능기를 함유할 경우, 순수한 상태 그대로(neat) 또는 적합한 불활성 용매 중에서 충분량의 원하는 염기와 중성 형태의 상기 화합물을 접촉시킴으로써 염기 부가 염을 수득할 수 있다. 약학적으로 허용가능한 염기 부가 염의 예로는 나트륨, 칼륨, 칼슘, 암모늄, 유기 아미노, 또는 마그네슘 염, 또는 유사한 염을 포함한다. 본 발명의 화합물이 상대적으로 염기성을 띠는 관능기를 함유할 경우, 순수한 상태 그대로 또는 적합한 불활성 용매 중에서 충분량의 원하는 산과 중성 형태의 상기 화합물을 접촉시킴으로써 산 부가 염을 수득할 수 있다. 약학적으로 허용가능한 산 부가 염의 예로는 무기산, 예로서, 염산, 브롬화수소산, 질산, 탄산, 모노하이드로겐탄산, 인산, 모노하이드로겐인산, 디하이드로겐인산, 황산, 모노하이드로겐황산, 요오드화수소산, 또는 아인산 등으로부터 유도된 염 뿐만 아니라, 상대적으로 비독성인 유기산, 예로서, 아세트산, 프로피온산, 이소부티르산, 말레산, 말론산, 벤조산, 숙신산, 수베르산, 푸마르산, 락트산, 만델산, 프탈산, 벤조술폰산, p-톨릴술폰산, 시트르산, 타르타르산, 메탄술폰산 등으로부터 유도된 염을 포함한다. 아미노산, 예로서, 알기네이트 등의 염, 유기산, 예로서, 글루쿠론산 또는 갈락투론산 등의 염 또한 포함한다(예컨대, 문헌 [Berge et al., Journal of Pharmaceutical Science 66: 1-19 (1977)] 참조). 본 발명의 특정의 구체적인 화합물은 화합물이 염기 또는 산 부가 염으로 전환될 수 있도록 허용하는 염기성 및 산성 관능기, 둘 모두를 포함한다. 당업자에게 공지된 다른 약학적으로 허용가능한 담체도 본 발명에 적합하다.

상세한 실시양태

I. Ad셈블리 방법

한 측면에서, 재조합 아데노바이러스를 제조하는 방법(본원에서는 "Ad셈블리(Adsembly)"로도 지칭된다)을 제공한다. 본 방법은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈, 또는 아데노바이러스 마크로모듈(하기 기술되는 바와 같은, 그의 돌연변이체)로부터 선택되는 2개 이상의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다. 일부 실시양태에서, 본 방법은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 또는 아데노바이러스 마크로모듈로부터 선택되는 3, 4, 또는 5개의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다. 핵산은 아데노바이러스 게놈 구성체일 수 있다. 아데노바이러스 게놈 구성체는 (예컨대, 포유동물 세포로 도입되었을 때) 발현시, 재조합 아데노바이러스를 형성할 수 있는 핵산이다. 핵산은 또한 (예컨대, 포유동물 세포로 도입되었을 때) 발현시, 추가 바이러스(예컨대, 헬퍼 바이러스)와 함께 재조합 아데노바이러스를 형성할 수 있는 부분 아데노바이러스 게놈 구성체일 수 있다. 그렇게 형성된 아데노바이러스는 복제 및 패킹될 수 있고, 이로써 자손 바이러스를 생산할 수 있다. 따라서, 본원에서 제공하는 방법은 포유동물 세포로 형질감염되었을 때, 단독으로 보충 세포주에서, 또는 헬퍼 바이러스와 함께 복제 및 패킹되어 자손 바이러스를 생산하는 아데노바이러스 게놈를 2개 이상의 게놈 모듈 또는 이종성 요소로부터 시험관내에서 조립하는 단계를 포함할 수 있다. 게놈 모듈은 진화상 보존되는 서열, 전사, 또는 작용 단위에 기초하여 선택될 수 있다. 일부 실시양태에서, 본 방법은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 및 E4 모듈로부터 선택되는 3개 이상의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다. 조립 후, 생성된 핵산(이는 또한 본원에서 "조립된 핵산"으로도 지칭된다)은 발현됨으로써(예컨대, 복제, 전사, 번역 및 패킹됨으로써) 재조합 아데노바이러스가 형성될 수 있다. 핵산의 발현은 시험관내, 계내, 세포에서(예컨대, 핵산의 세포내로의 형질감염에 의해), 또는 생체내에서 실행될 수 있다. 특정 실시양태에서, 발현은 세포에서 실행될 수 있고, 이로써 바이러스가 생산될 수 있다.

본원에서 사용되는 바, "아데노바이러스 유전자 모듈"이라는 용어는 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 또는 그의 마크로모듈을 의미한다. 따라서, 아데노바이러스 유전자 모듈은 핵산(예컨대, DNA)이다. 본원에서 사용되는 바, "개별 아데노바이러스 유전자 모듈"은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 또는 E4 모듈을 의미한다. 일부 실시양태에서, 개별 아데노바이러스 유전자 모듈 중 하나 이상의 것이 핵산을 조립하기 이전에 보다 작은 서브모듈로부터 조립될 수 있다. 아데노바이러스 마크로모듈은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 중 2, 3, 또는 4개로 이루어진 조합물이다. 그러므로, 마크로모듈은 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 중 2, 3, 또는 4개를 포함하는 선형 가닥의 핵산(예컨대, DNA)이다. 본원에서 사용되는 바, "아데노바이러스 마크로모듈"이라는 용어는

E1-L2 마크로모듈(즉, E1 모듈 및 E2-L2 모듈이 조합된 것을 포함하는 핵산);

E1-L4 마크로모듈(즉, E1 모듈, E2-L2 모듈 및 L3-L4 모듈이 조합된 것을 포함하는 핵산);

E1-E3 마크로모듈(즉, E1 모듈, E2-L2 모듈, L3-L4 모듈 및 E3 모듈이 조합된 것을 포함하는 핵산);

E2-L4 마크로모듈(즉, E2-L2 모듈 및 L3-L4 모듈을 포함하는 핵산, 이는 또한 본원에서 "코어 마크로모듈"로서도 지칭된다);

E2-E3 마크로모듈(즉, E2-L2 모듈, L3-L4 모듈 및 E3 모듈이 조합된 것을 포함하는 핵산);

E2-E4 마크로모듈(즉, E2-L2 모듈, L3-L4 모듈, E3 모듈 및 E4 모듈이 조합된 것을 포함하는 핵산);

L3-E3 마크로모듈(즉, L3-L4 모듈, 및 E3 모듈이 조합된 것을 포함하는 핵산);

L3-E4 마크로모듈(즉, L3-L4 모듈, E3 모듈 및 E4 모듈이 조합된 것을 포함하는 핵산); 및

E3-E4 마크로모듈(즉, E3 모듈 및 E4 모듈이 조합된 것을 포함하는 핵산)을 의미한다.

일부 실시양태에서, 아데노바이러스 마크로모듈은 E2-L4 마크로모듈(즉, 코어 마크로모듈) 또는 E3-E4 마크로모듈이다. 아데노바이러스 마크로모듈이 핵산 조립을 위한 2개 이상의 선택된 아데노바이러스 모듈 중의 하나로서 사용되는 경우, 다른 나머지의 것인 선택된 아데노바이러스 모듈(들)은 상기 아데노바이러스 마크로모듈 내에 포함되어 있는 개별 아데노바이러스 마크로모듈이 아니다. 다시 말하면, 각 개별 아데노바이러스 유전자 모듈은 따로따로든 또는 마크로모듈 내에든 간에 조립된 핵산 중에는 단 한번만 존재한다. 예를 들어, 핵산 조립을 위한 2개 이상의 선택된 아데노바이러스 유전자 모듈 중 하나가 코어 마크로모듈인 경우, 조립된 핵산 중에 포함시키고자 하는 또 다른 모듈로서는 E2-L2도 L3-L4 모듈도 선택되지 않는다. 유사하게, 3개 이상의 아데노바이러스 유전자 모듈이 선택되는 경우, 아데노바이러스 마크로모듈은 E1-E3 마크로모듈도 E2-E4 마크로모듈도 아니다.

일부 실시양태에서, 본 방법은 (i) E1 모듈, (ii) 코어 마크로모듈, 및 (iii) E3 모듈, E4 모듈 또는 E3-E4 마크로모듈로부터 선택되는 3개의 아데노바이러스 유전자 모듈로 핵산을 조립하는 단계를 포함한다. 본 방법은 또한 E1 모듈, 코어 마크로모듈, E3 모듈, 및 E4 모듈로부터 선택되는 4개의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다.

일부 실시양태에서, 핵산 조립 이전에 하나 이상의 아데노바이러스 유전자 모듈을 조합함으로써 마크로모듈을 형성할 수 있다. 마크로모듈을 형성하는 경우, 본 방법은 마크로모듈 및 마크로모듈 내에 포함되어 있지 않은 하나 이상의 개별 아데노바이러스 유전자 모듈(즉, E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 및/또는 E4 모듈)로부터 핵산을 조립하는 단계를 포함한다. 일부 실시양태에서, 마크로모듈은 코어 마크로모듈이다. 따라서, 일부 실시양태에서, 본 방법은 코어 마크로모듈, 및 E1 모듈, E3 모듈, 또는 E4 모듈로부터 선택되는 하나 이상의 아데노바이러스 유전자 모듈을 사용하여 핵산을 조립하는 단계를 포함한다.

아데노바이러스는 핵에서 복제되는 외피 비보유의 20면체 바이러스이다. 본원에서 제공하는 아데노바이러스 유전자 모듈은 예를 들어, 문헌 [Davison et al., Journal of General Virology, (2003), 84, 28695-2938]에 기술되어 있는 바와 같이, 아데노바이러스 게놈 중의 특정 위치를 언급한다. 일부 실시양태에서, 아데노바이러스 유전자 모듈은 인간 아데노바이러스로부터 유래된 것이다. 도 5는 본원에서 제공하는 아데노바이러스 유전자 모듈 뿐만 아니라, 그의 대략적인 크기를 킬로베이스 (kb)로 나타낸 간략화된 지도이다. 각 모듈은 다중 유전자 생성물 및 선택적 유전자 스플라이싱 정렬을 코딩할 수 있다.

*본원에서 사용되는 바, "E1 모듈"은 아데노바이러스 역위 말단 반복부(ITR: inverted terminal repeat)를 포함하는 핵산이다. E1 모듈은 조립된 핵산의 단백질 코딩 영역에 작동가능하게 연결될 수 있는 프로모터를 추가로 포함할 수 있다. E1 모듈은 전형적으로 아데노바이러스 E1A 및/또는 E1B 영역으로부터 유래된 것이다. ITR 영역 이외에도, E1 모듈은 또한 아데노바이러스 게놈의 E1 말단에서부터 바이러스 폴리머라제 코딩 영역(하기 논의된다)까지에서 발견되는 임의의 바이러스 유전자를 포함할 수 있다. 예를 들어, E1 모듈은 (예컨대, pRB 패밀리의 불활성 인자를 코딩하는) 주요 전사 활성 인자 E1A에 대한 코딩 영역, (예컨대, 아포프토시스 차단제를 포함하는) E1B-19K에 대한 코딩 영역, E1B-55K(예컨대, p53 결합, mre 결합 및 바이러스 mRNA 외수송 인자)에 대한 코딩 영역 및/또는 (예컨대, 마이너 구조 단백질 및 바이러스 캡시드 상의 헥손과 상호작용하는 단백질을 코딩하는) pIX에 대한 코딩 영역을 추가로 포함할 수 있다. E1 모듈의 길이는 대략 4 kb, 3 kb, 2 kb 또는 1 kb일 수 있다. 일부 실시양태에서, E1 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 E1A 및 E1B 영역과 같은 크기이다(예컨대, 도 5 참조).

본원에서 사용되는 바, "E2-L2" 모듈은 바이러스 DNA 폴리머라제 코딩 영역 및 헥손 단백질 코딩 영역 중 1 이상을 포함하는 핵산이다. 일부 실시양태에서, E2-L2 모듈은 또한 바이러스 DNA 결합 단백질 코딩 영역을 포함한다. E2-L2 모듈은 전형적으로는 아데노바이러스 E2B, L1 및/또는 L2 영역으로부터 유래된 것이다. E2-L2 모듈은 (예컨대, 후기 전사 활성 인자 및 바이러스 DNA의 바이러스 캡시드 내로의 패키징을 돕는 단백질을 코딩하는) E2B IVa2에 대한 코딩 영역, (예컨대, 바이러스 DNA 폴리머라제를 코딩하는) E2B Pol에 대한 코딩 영역, (예컨대, 바이러스 게놈의 말단에 부착되고, 바이러스 복제 및 패키징에 필요한 말단 단백질을 코딩하는) E2B pTP에 대한 코딩 영역, (예컨대, 바이러스 DNA의 캡시드 내로의 패키징에 필요한 단백질을 코딩하는) L1 52K에 대한 코딩 영역, (예컨대, 캡시드를 안정화시키는 데 도움을 주는 마이너 구조 단백질을 코딩하는) L1 IIIa에 대한 코딩 영역, (예컨대, 섬유가 돌출되어 있는 캡시드의 두정을 형성하는 메이저 구조 단백질을 코딩하는) L2 III(펜톤)에 대한 코딩 영역, (예컨대, 히스톤 H3과 상동성을 가지고 있고, 캡시드 중에서 바이러스 DNA와 회합하는 코어 구조 단백질을 코딩하는) L2 pVII에 대한 코딩 영역, (예컨대, DNA와 바이러스 캡시드 사이의 회합을 형성하는 코어 구조 단백질을 코딩하는) L2 V에 대한 코딩 영역, 및 (예컨대, 바이러스 게놈에 결합하여, 응축시키는 코어 구조 단백질을 코딩하는) L2 pX에 대한 코딩 영역을 추가로 포함할 수 있다. 일부 실시양태에서, E2-L2 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 E2B, L1 및 L2 영역과 같은 크기이다(예컨대, 도 5 참조).

본원에서 사용되는 바, "L3-L4" 모듈은 바이러스 DNA 폴리머라제 코딩 영역 및 헥손 단백질 코딩 영역 중 1 이상을 포함하는 핵산이다. 일부 실시양태에서, L3-L4 모듈은 또한 바이러스 DNA 결합 단백질 코딩 영역을 포함할 수 있다. 일부 실시양태에서, E2-L2 모듈이 바이러스 DNA 폴리머라제 코딩 영역을 포함할 경우, L3-L4는 바이러스 DN코딩 영역을 포함하지 않고, 그 반대의 경우도 해당된다. 유사하게, E2-L2 모듈이 헥손 단백질 코딩 영역을 포함할 경우, L3-L4는 헥손 단백질 코딩 영역을 포함하지 않을 수 있고, 그 반대의 경우도 해당된다. 유사하게, E2-L2 모듈이 바이러스 DNA 결합 단백질 코딩 영역을 포함할 경우, L3-L4는 바이러스 DNA 결합 단백질 코딩 영역을 포함하지 않을 수 있고, 그 반대의 경우도 해당된다. 다시 말하면, 바이러스 DNA 폴리머라제 코딩 영역, 헥손 단백질 코딩 영역, 및 바이러스 DNA 결합 단백질 코딩 영역은 전형적으로는 조립된 핵산 중에 단 한번만 출현한다. L3-L4 모듈은 또한 (예컨대, 두정에서 캡시드와 바이러스 게놈 DNA 사이의 회합을 형성하는 마이너 구조 단백질을 코딩하는) L3 pVI에 대한 코딩 영역, (예컨대, 캡시드의 삼각형을 형성하는 마이너 구조 단백질을 코딩하는) L3 II(헥손)에 대한 코딩 영역, (예컨대, 바이러스 단백질을 완전한 캡시드 조립체로 프로세싱하는 바이러스 프로테아제를 코딩하는) L3 23K에 대한 코딩 영역, (예컨대, 바이러스 DNA에 결합하여 복제를 촉진시키는 DNA 결합 단백질을 코딩하는) E2A DBP에 대한 코딩 영역, (예컨대, 세포 단백질 합성을 억제시키고, 바이러스 후기 단백질의 번역을 촉진시키는 단백질을 코딩하는) L4 100K에 대한 코딩 영역, (예컨대, 후기 바이러스 유전자의 스플라이싱을 촉진시키는 단백질을 코딩하는) L4 33K에 대한 코딩 영역, 하나 이상의 섬유 단백질에 대한 코딩 영역, 및 (예컨대, 후기 바이러스 유전자 발현을 촉진시키고, 바이러스 DNA 패키징을 돕는 단백질을 코딩하는) L4 22K에 대한 코딩 영역을 포함할 수 있다. 일부 실시양태에서, L3-L4 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 L3, E2A 및 L4 영역 또는 자연 상태에서 발견되는 아데노바이러스의 L3, E2A, L4 및 L5 영역과 같은 크기이다(예컨대, 도 5 참조).

본원에서 사용되는 바, "코어 마크로모듈"(이는 또한 본원에서 "E2-L4 마크로모듈"로도 지칭된다)은 바이러스 DNA 폴리머라제 코딩 영역 및 헥손 단백질 코딩 영역 중 1 이상을 포함하는 핵산을 의미한다. 일부 실시양태에서, 코어 마크로모듈은 또한 바이러스 DNA 결합 단백질 코딩 영역을 포함할 수 있다. 일부 실시양태에서, 코어 마크로모듈은 바이러스 구조 단백질 대부분과, 그 뿐만 아니라, DNA 복제 및 패키징에 필요한 것들을 포함한다. 일부 실시양태에서, 코어 마크로모듈은 바이러스 DNA 폴리머라제 코딩 영역, 헥손 단백질 코딩 영역 및 바이러스 DNA 폴리머라제 코딩 영역을 포함한다. 다른 실시양태에서, 코어는 또한 (예컨대, 두정에서 캡시드와 바이러스 게놈 DNA 사이의 회합을 형성하는 마이너 구조 단백질을 코딩하는) L3 pVI에 대한 코딩 영역, (예컨대, 캡시드의 삼각형을 형성하는 메이저 구조 단백질을 코딩하는) L3 II(헥손)에 대한 코딩 영역, (예컨대, 바이러스 단백질을 완전한 캡시드 조립체로 프로세싱하는 바이러스 프로테아제를 코딩하는) L3 23K에 대한 코딩 영역, (예컨대, 바이러스 DNA에 결합하여 복제를 촉진시키는 DNA 결합 단백질을 코딩하는) E2A DBP에 대한 코딩 영역, (예컨대, 세포 단백질 합성을 억제시키고, 바이러스 후기 단백질의 번역을 촉진시키는 단백질을 코딩하는) L4 100K에 대한 코딩 영역, (예컨대, 후기 바이러스 유전자의 스플라이싱을 촉진시키는 단백질을 코딩하는) L4 33K에 대한 코딩 영역, 및 (예컨대, 후기 바이러스 유전자 발현을 촉진시키고, 바이러스 DNA 패키징을 돕는 단백질을 코딩하는) L4 22K에 대한 코딩 영역, (예컨대, 후기 전사 활성 인자 및 바이러스 DNA의 바이러스 캡시드 내로의 패키징을 돕는 단백질을 코딩하는) E2B IVa2에 대한 코딩 영역, (예컨대, 바이러스 DNA 폴리머라제를 코딩하는) E2B Pol에 대한 코딩 영역, (예컨대, 바이러스 게놈의 말단에 부착되고, 바이러스 복제 및 패키징에 필요한 말단 단백질을 코딩하는) E2B pTP에 대한 코딩 영역, (예컨대, 바이러스 DNA의 캡시드 내로의 패키징에 필요한 단백질을 코딩하는) L1 52K에 대한 코딩 영역, (예컨대, 캡시드를 안정화시키는 데 도움을 주는 마이너 구조 단백질을 코딩하는) L1 IIIa에 대한 코딩 영역, (예컨대, 섬유가 돌출되어 있는 캡시드의 두정을 형성하는 메이저 구조 단백질을 코딩하는) L2 III(펜톤)에 대한 코딩 영역, (예컨대, 히스톤 H3과 상동성을 가지고 있고, 캡시드 중에서 바이러스 DNA와 회합하는 코어 구조 단백질을 코딩하는) L2 pVII에 대한 코딩 영역, (예컨대, DNA와 바이러스 캡시드 사이의 회합을 형성하는 코어 구조 단백질을 코딩하는) L2 V에 대한 코딩 영역, 하나 이상의 섬유 단백질에 대한 코딩 영역 및 (예컨대, 바이러스 게놈에 결합하여, 응축시키는 코어 구조 단백질을 코딩하는) L2 pX에 대한 코딩 영역을 포함할 수 있다. 일부 실시양태에서, L3-L4 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 E2B, L1, L2, L3, E2A 및 L4 영역 또는 자연 상태에서 발견되는 아데노바이러스의 E2B, L1, L2, L3, E2A, L4 및 L5 영역과 같은 크기이다(예컨대, 도 5 참조).

바이러스 DNA 폴리머라제 유전자에 의해 코딩되는 단백질은 서열 번호: 32(도 7a-c)에 기재된 인간 Ad5 DNA 폴리머라제 또는 또 다른 종으로부터 유래된 그의 상동체의 아미노산 996-1103 중 50개 이상의 인접한 아미노산(예컨대, 상기 아미노산 모두)와 45% 이상(예컨대, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 100%)의 동일성을 공유하는 서열을 포함한다. 헥손 유전자에 의해 코딩되는 단백질은 서열 번호: 73(도 7d-g)에 기재된 인간 Ad5 헥손 또는 또 다른 종으로부터 유래된 그의 상동체의 아미노산 501-747 중 50개 이상의 인접한 아미노산(예컨대, 상기 아미노산 모두)와 45% 이상(예컨대, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 100%)의 동일성을 공유하는 서열을 포함한다. 바이러스 DNA 결합 단백질 유전자에 의해 코딩되는 단백질은 서열 번호: 103(도 7h-i)에 기재된 인간 Ad5 DNA 결합 단백질 또는 또 다른 종으로부터 유래된 그의 상동체의 아미노산 408-475 중 50개 이상의 인접한 아미노산(예컨대, 상기 아미노산 모두)와 35% 이상(예컨대, 45%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 100%)의 동일성을 공유하는 서열을 포함한다.

본원에서 사용되는 바, "E4 모듈"은 아데노바이러스 역위 말단 반복부(ITR)을 포함하는 핵산이다. 일부 실시양태에서, E4는 하나 이상의 섬유 단백질에 대한 코딩 영역을 추가로 포함한다. E4 모듈은 (예컨대, 바이러스 전사의 E2F 전사활성화를 매개하는 단백질을 코딩하는) E4 orf 6/7에 대한 코딩 영역, (예컨대, 바이러스 DNA 합성을 촉진시키고, 바이러스 후기 mRNA를 안정화시키고, 외수송하고, 스플라이싱을 촉진시키는 단백질을 코딩하는) E4 orf 6에 대한 코딩 영역, (예컨대, 바이러스 전사 및 스플라이싱을 조절하고, PP2A를 조정하는 단백질을 코딩하는) E4 orf4에 대한 코딩 영역, (예컨대, p53 매개 전사를 차단하고, MRN DNA 수복 복합체를 파괴시키고, 콘카테머화를 막는 단백질을 코딩하는) E4 orf3에 대한 코딩 영역, E4 orf2에 대한 코딩 영역, 및 (예컨대, PI3 키나제를 통한 신호 전달을 촉진시킴으로써 단백질 합성 및 세포 생존을 유도하는 단백질을 코딩하는) E4 orf1에 대한 코딩 영역을 추가로 포함할 수 있다. 일부 실시양태에서, E4 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 E4 영역, 또는 자연 상태에서 발견되는 아데노바이러스의 E4 및 L5 영역과 같은 크기이다(예컨대, 도 5 참조).

본원에서 사용되는 바, "E3 모듈"은 하나 이상의 섬유 단백질에 대한 코딩 영역 및/또는 아데노바이러스 역위 말단 반복부(ITR)를 포함하는 핵산이다. 일부 실시양태에서, E3 모듈은 (도 5에 제시된 바와 같이) pVIII의 단백질 코딩 영역의 말단에서부터 게놈의 우측 말단에 위치하는 ITR까지의 임의의 공지된 아데노바이러스 서열을 포함한다. pVIII 코딩 영역은 135(도 7j)에 기재된 인간 Ad5 pVIII 단백질의 아미노산 6-43 중 50개 이상의 인접한 아미노산(예컨대, 상기 아미노산 모두)와 35% 이상(예컨대, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% 또는 100%)의 동일성을 공유하는 서열을 포함하는 단백질을 코딩하는 임의의 유전자이다. E3 모듈은 (예컨대, 마이너 구조 단백질을 코딩하는) L4 pVIII에 대한 코딩 영역, E3 12.5K에 대한 코딩 영역, (예컨대, 아포프토시스를 차단하는 단백질을 코딩하는) E3 CR1α에 대한 코딩 영역, (예컨대, MHC-I 항원 제시를 억제하는 면역조절성 단백질을 코딩하는) E3 gp19K에 대한 코딩 영역, (예컨대, 바이러스 방출을 위해 세포를 효율적으로 용해시키는 작용을 하는 단백질을 코딩하는) E3 ADP에 대한 코딩 영역, (예컨대, 세포 표면으로부터 아포프토시스 촉진성 FasL 및 TRAIL을 제거하는 면역조절성 단백질을 코딩하는) E3 RIDα에 대한 코딩 영역, (예컨대, 세포 표면으로부터 아포프토시스 촉진성 FasL 및 TRAIL을 제거하는 면역조절성 단백질을 코딩하는) E3 RIDβ-에 대한 코딩 영역, (예컨대, 아포프토시스를 차단하는 단백질을 코딩하는) E3 14.7K에 대한 코딩 영역, 및 (예컨대, 펜톤 염기로부터 연장되고, 수용체 결합을 담당하는 메이저 구조 단백질을 코딩하는) L5 IV(섬유)에 대한 코딩 영역을 추가로 포함할 수 있다. 일부 실시양태에서, E3 모듈의 길이는 대략적으로는 자연 상태에서 발견되는 아데노바이러스의 E3 영역, 또는 자연 상태에서 발견되는 아데노바이러스의 E3 및 L5 영역과 같은 크기이다(예컨대, 도 5 참조).

본원에서 사용되는 바, "E3-E4 마크로모듈"은 아데노바이러스 역위 말단 반복부(ITR)를 포함하는 핵산이다. E-3-E4 마크로모듈은 (도 5에 제시된 바와 같이) pVIII의 단백질 코딩 영역의 말단에서부터 게놈의 우측 말단에 위치하는 ITR까지의 임의의 공지된 아데노바이러스 서열을 추가로 포함할 수 있다. E3-E4 마크로모듈은 (예컨대, 바이러스 전사의 E2F 전사활성화를 매개하는 단백질을 코딩하는) E4 orf 6/7에 대한 코딩 영역, (예컨대, 바이러스 DNA 합성을 촉진시키고, 바이러스 후기 mRNA를 안정화시키고, 외수송하고, 스플라이싱을 촉진시키는 단백질을 코딩하는) E4 orf 6에 대한 코딩 영역, (예컨대, 바이러스 전사 및 스플라이싱을 조절하고, PP2A를 조정하는 단백질을 코딩하는) E4 orf4에 대한 코딩 영역, (예컨대, p53 매개 전사를 차단하고, MRN DNA 수복 복합체를 파괴시키고, 콘카테머화를 막는 단백질을 코딩하는) E4 orf3에 대한 코딩 영역, E4 orf2에 대한 코딩 영역, (예컨대, PI3 키나제를 통한 신호 전달을 촉진시킴으로써 단백질 합성 및 세포 생존을 유도하는 단백질을 코딩하는) E4 orf1에 대한 코딩 영역, (예컨대, 마이너 구조 단백질을 코딩하는) L4 pVIII에 대한 코딩 영역, E3 12.5K에 대한 코딩 영역, (예컨대, 아포프토시스를 차단하는 단백질을 코딩하는) E3 CR1α에 대한 코딩 영역, (예컨대, MHC-I 항원 제시를 억제하는 면역조절성 단백질을 코딩하는) E3 gp19K에 대한 코딩 영역, (예컨대, 바이러스 방출을 위해 세포를 효율적으로 용해시키는 작용을 하는 단백질을 코딩하는) E3 ADP에 대한 코딩 영역, (예컨대, 세포 표면으로부터 아포프토시스 촉진성 FasL 및 TRAIL을 제거하는 면역조절성 단백질을 코딩하는) E3 RIDα에 대한 코딩 영역, (예컨대, 세포 표면으로부터 아포프토시스 촉진성 FasL 및 TRAIL을 제거하는 면역조절성 단백질을 코딩하는) E3 RIDβ-에 대한 코딩 영역, (예컨대, 아포프토시스를 차단하는 단백질을 코딩하는) E3 14.7K에 대한 코딩 영역, 및 (예컨대, 펜톤 염기로부터 연장되고, 수용체 결합을 담당하는 메이저 구조 단백질을 코딩하는) L5 IV(섬유)에 대한 코딩 영역을 추가로 포함할 수 있다.

일부 실시양태에서, 하나 이상의 아데노바이러스 유전자 모듈은 아데노바이러스 유전자 모듈이 유래된 천연(예컨대, 야생형) 아데노바이러스에서 발견되는 모듈 서열과 비교하여 하나 이상의 돌연변이(예컨대, 핵산의 치환, 부가 또는 결실)을 포함한다. 예를 들어, 본원에서 제공하는 핵산은 특정 세포 조건하에서의 핵산의 세포로의 형질감염을 통해 복제 수행 능력이 있는(복제 적격)(replication competent) 아데노바이러스가 형성될 수 있도록 하기 위해 충분한 개수의 아데노바이러스 유전자 모듈을 코딩할 수 있다. 하나 이상의 아데노바이러스 유전자 모듈 중의 돌연변이를 통해 생성된 아데노바이러스는 일부 세포(예컨대, 이환 세포, 예로서, 암 세포)에서는 복제가 가능할 수 있지만, 다른 세포(예컨대, 비이환 세포, 예로서, 건강한 세포)에서는 복제가 불가능할 수 있다. 돌연변이는 또한 하나 이상의 단백질 코딩 영역의 부가(예컨대, 하나 이상의 외인성 또는 이종성 단백질 코딩 영역, 예로서, 비바이러스 단백질 코딩 영역의 부가)를 포함할 수 있다. 하나 이상의 단백질의 부가가 추가의 바이러스 기능성을 제공할 수 있거나, 바이러스 기능성(예컨대, 복제)을 상실시킬 수 있거나, 바이러스 검출 방법(예컨대, 형광성 마커)을 제공할 수 있거나, 바이러스 정제 방법(예컨대, His 태깅된 캡시드 단백질)을 제공할 수 있거나, 또는 추가 사용을 위해 후속하여 단리되고/거나 정제되는, 관심의 대상이 되는 단백질을 생산할 수 있는 바이러스를 제공할 수 있다. 따라서, 돌연변이는 바이러스의 작용을 추가할 수 있거나, 바이러스의 작용을 감축시킬 수 있다. 따라서, 본원에서 제공하는 재조합 아데노바이러스는 외인성(예컨대, 이종성) 핵산의 도입에 의해, 또는 천연 핵산 서열의 변경에 의해 변형된 아데노바이러스를 포함한다. 변경은 상기 기술된 하나 이상의 아데노바이러스 유전자 모듈에서의 돌연변이화를 통해, 또는 천연 아데노바이러스 게놈에 존재하는 하나 이상의 아데노바이러스 유전자 모듈의 절제에 의해 이루어질 수 있다.

따라서, 일부 실시양태에서, 핵산은 돌연변이된 아데노바이러스 핵산 서열을 포함한다. 아데노바이러스 핵산 서열은 천연 상태의 또는 천연 아데노바이러스(예컨대, 야생형)에서 발견되는 서열이다. 돌연변이된 아데노바이러스 핵산 서열은 상기 기술된 하나 이상의 아데노바이러스 유전자 모듈에서의 돌연변이화로부터, 또는 천연 아데노바이러스 게놈에 존재하는 하나 이상의 아데노바이러스 유전자 모듈의 절제에 의해 생성될 수 있다. 특정 실시양태에서, 핵산은 결실된 아데노바이러스 핵산 서열, 이소성 아데노바이러스 핵산 서열, 또는 (예컨대, 비아데노바이러스 유전자 생성물을 코딩하는) 외인성(예컨대, 이종성) 핵산 서열을 포함한다. 돌연변이된 아데노바이러스 핵산 서열은 변경된 기능성을 부여하는 돌연변이된 E4-ORF3 유전자 생성물, 돌연변이된 E1B-55k 유전자 생성물, 돌연변이된 아데노바이러스 섬유 유전자 생성물, 돌연변이된 바이러스 코트 단백질, 프로드럭 전환 효소, 리포터 단백질, 돌연변이된 헥손 단백질, pIX에 융합된 단백질, 특정 세포에 독성을 띠는 단백질, 핵산이 수득된 유형 이외의 다른 아데노바이러스로부터 유래된 완전한 또는 부분 섬유 유전자, 및/또는 표적화 단백질(예컨대, 종양 표적화 단백질 또는 혈관구조(vasculature) 표적화 단백질)을 포함할 수 있다.

일부 실시양태에서, 핵산은 E1 모듈을 포함한다. 핵산은 또한 E1 모듈 및 E4 모듈, 둘 모두를 포함할 수 있다. 특정 실시양태에서, 핵산은 E1 모듈 및 E2-L2 모듈을 포함한다. 핵산은 또한 E1 모듈 및 L3-L4 모듈을 포함할 수 있다. 핵산은 또한 E1 모듈, E2-L2 모듈 및 L3-L4 모듈을 포함할 수 있다.

일부 실시양태에서, 본 방법은 E1 모듈, 코어 모듈, E3 모듈 및/또는 그의 유도체 또는 구성 성분으로부터 선택되는 3가지 이상의 아데노바이러스 유전자 모듈로부터 핵산을 조립하는 단계를 포함한다. 관련된 실시양태에서, 인간 Ad5의 일례에서, 본 발명은 E1 모듈, E2- L2 모듈, L3-L4 모듈, E3 모듈, 및 E4 모듈로부터 핵산을 조립하는 단계를 포함한다. 특정 실시양태에서, 형성된 핵산의 길이는 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 또는 50 kb 이상이다. 일부 실시양태에서, 형성된 핵산의 길이는 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 kb 이상이다. 일부 실시양태에서, 형성된 핵산의 길이는 10, 11, 12, 13, 14, 15 kb 이상이다. 일부 실시양태에서, 형성된 핵산의 길이는 10, 11, 12 kb 이상이다. 일부 실시양태에서, 형성된 핵산의 길이는 12 kb 이상이다.

본원에서 제공하는 방법에 의해 형성된 핵산은 임의의 발현이 가능한 핵산일 수 있다. 핵산은 발현됨으로써 아데노바이러스를 생산할 수 있다. 아데노바이러스는 감염성일 수 있고/거나, 자가 복제가 가능한(예컨대, 복제 수행 능력이 있는) 것일 수 있다. 일부 실시양태에서, 핵산은 플라스미드이다.

일부 실시양태에서, 조립 단계는 아데노바이러스 유전자 모듈(또는 마크로모듈)을 함께 조립하여 핵산을 형성하는 단계를 포함하는데, 여기서, 아데노바이러스 모듈 또는 마크로모듈이 배향은 세포 내로의 도입시(예컨대, 세포에서의 바이러사의 발현 또는 형성시) 복제가능한 아데노바이러스를 형성하는 데 도움이 된다. 따라서, 일부 실시양태에서, 아데노바이러스 유전자 모듈(예컨대, 마크로모듈)은 배향 특이 방식으로 조립된다. 예를 들어, 소위 "게이트웨이"라는 기술 및/또는 서열 및 결찰 독립 클로닝 기술("SLIC")을 비롯한, 임의의 적용가능한 클로닝 기법이 사용될 수 있다. 게이트웨이 기술 또는 유사한 기술은 부위 특이 재조합을 사용하여 핵산(예컨대, DNA) 단편을 한 조각의 핵산으로부터 또 다른 것으로 교환한다. 최종 결과는 핵산 서열의 목적 벡터 또는 플라스미드 내로의 삽입이다. 본원에서 이러한 기술 및 방법을 총칭하여 "부위 특이 재조합 방법" 또는 "SSR(site specific recombination) 방법"이라고 지칭한다. SSR 방법의 상기와 같은 적용에 있어서, DNA 단편을 엔트리 벡터로부터 목적 벡터로 이동시키면, 그 결과, 목적 벡터는 증식될 수 있(도 9). 엔트리 벡터 및 목적 벡터는 전형적으로 재조합 부위를 포함한다. 일부 실시양태에서, 엔트리 벡터는 재조합 수행 능력이 있는 것이다. 다른 실시양태에서, 엔트리 벡터는 하이브리드화 수행 능력이 있는 것이다. 하이브리드화 수행 능력이 있는 엔트리 벡터는 하나 이상의 아데노바이러스 유전자 모듈을 포함할 수 있는데, 이는 효소적 제한에 의해 엔트리 벡터로부터 유리될 수 있고, 이로써, 아데노바이러스 유전자 모듈이 유리될 수 있다. 본원에서는 아데노바이러스 유전자 모듈을 목적 벡터 내로 삽입하여 핵산(예컨대, 핵산 플라스미드)을 형성하는, 게이트웨이 기술을 적합화시킨 SSR 방법을 제공한다. 게이트웨이 기술의 일반 사용 방법은 예를 들어, 문헌 ([Sone et. al., J Biotechnol. (2008) Sep 10; 136(3- 4): 113-21]; [Hartley, et al., Genome Res. (2000), 10, 1788-1795]; 및 [Sasaki, et al., J. Biotechnol. (2004), 107, 233-243])에 기술되어 있다.

예를 들어, SSR 방법을 사용할 경우, 조립 단계는 재조합 수행 능력이 있는 목적 벡터(예컨대, 재조합 부위 핵산 서열을 포함하는 목적 벡터) 및 하나 이상의 아데노바이러스 유전자 모듈을 인터그라제(예컨대, 람다 파지 인터그라제, 람다 파지 엑시지오나제, 또는 박테리아 숙주 통합 인자)와 접촉시켜 아데노바이러스 유전자 모듈 벡터를 형성하는 것을 포함한다. 하나 이상의 아데노바이러스 유전자 모듈은 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈(예컨대, 재조합 부위 핵산 서열을 포함하는 아데노바이러스 유전자 모듈)이다. 일부 실시양태에서, 하나 이상의 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈은 재조합 부위 핵산 서열을 아데노바이러스 유전자 모듈에 첨가하여 하나 이상의 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈을 형성함으로써 형성이 된다. 다른 실시양태에서, 하나 이상의 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈은 재조합 수행 능력이 있는 엔트리 벡터의 일부이다. 일부 실시양태에서, 하나 이상의 아데노바이러스 유전자 모듈을 포함하는 재조합 수행 능력이 있는 엔트리 벡터는 하나 이상의 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈 및 재조합 수행 능력이 있는 도너 벡터를 인터그라제와 접촉시켜 하나 이상의 아데노바이러스 유전자 모듈을 포함하는 재조합 수행 능력이 있는 엔트리 벡터를 형성함으로써 형성이 된다. 따라서, 일부 실시양태에서, 재조합 수행 능력이 있는 목적 벡터 및 하나 이상의 아데노바이러스 유전자 모듈을 포함하는 하나 이상의 재조합 수행 능력이 있는 엔트리 벡터를 인터그라제 활성과 접촉시켜 아데노바이러스 유전자 모듈 벡터를 형성한다.

도 20-21은 인간 Ad5에 대해 개발된, 본원에서 제공하는 본 발명의 실시양태를 다이어그램으로 나타낸 것이다. 조립 단계는 각각 아데노바이러스 유전자 모듈을 포함하는 것인 목적 벡터 및 하나 이상의 엔트리 벡터를 람다 파지 인터그라제, 람다 파지 엑시지오나제, 또는 박테리아 숙주 통합 인자 중 하나 이상과 조합하여 아데노바이러스 유전자 모듈 벡터를 형성하는 것을 포함한다. 일부 실시양태에서, 엔트리 벡터는 재조합 부위를 아데노바이러스 유전자 모듈에 첨가한 후, 도너(donor) 벡터, 및 람다 파지 인터그라제, 람다 파지 엑시지오나제, 또는 박테리아 숙주 통합 인자 중 하나 이상과 조합하여 아데노바이러스 유전자 모듈 엔트리 벡터를 형성함으로써 형성이 된다.

목적 벡터는 아데노바이러스 유전자 모듈을 그에 연결시키고자 하는 것인 핵산, 예컨대, 플라스미드이다. 연결은 목적 벡터 내에 포함시키고자 하는 (예컨대, 삽입시키고자 하는) 아데노바이러스 유전자 모듈을 포함하는 하나 이상의 엔트리 벡터의 교환에 의해 이루어질 수 있다. 목적 벡터는 재조합 수행 능력이 있는 목적 벡터 및 하나 이상의 아데노바이러스 유전자 모듈을 인터그라제(예컨대, 인터그라제, 엑시지오나제, 및/또는 숙주 통합 인자)와 접촉(예컨대, 조합)시키기 전에 존재하고 있는 하나 이상의 아데노바이러스 유전자 모듈을 가질 수 있다.

본원에서는 "att" 부위로도 지칭되는 재조합 부위 핵산 서열은 두 핵산 사이의 시험관내 부위 특이 재조합을 촉진시키는 핵산 서열이다. 일부 실시양태에서, 재조합 부위 핵산 서열의 길이는 대략 21 bp이다. 예를 들어, 재조합 부위 핵산 서열은 게이트웨이 재조합 신호, 예컨대, 도 10에 제시되어 있는 것 및/또는 문헌 ([Sone et. al., J Biotechnol . (2008) Sep 10;136(3-4): 113-21]; [Hartley, et al., Genome Res. (2000), 10, 1788- 1795]; 및 [Sasaki, et al., J. Biotechnol. (2004), 107, 233-243])에 기재되어 있는 것(예컨대, attB 부위, attL 부위, attR 부위, attP 부위, attBr 부위, attPr 부위 등)일 수 있다.

일부 실시양태에서, 하나 이상의 재조합 수행 능력이 있는 아데노바이러스 유전자 모듈은 도너 벡터의 일부를 형성한다(또는 도너 벡터 내에 존재한다). 도너 벡터는 게이트웨이 기술 또는 유사한 유형의 클로닝 기술과 화합성이 플라스미드일 수 있다.

일부 실시양태에서, DEST 벡터는 상이한 역선택 카세트를 포함한다. 역선택 카세트는 특정 조건하에서는 박테리아 세포의 성장을 방해하는 임의의 DNA 단편이다. 도 22에는 본원에서 제공하는 본 발명에서 사용된 다양한 역선택 카세트의 효능이 기술되어 있다.

도 19는 다중 부위 게이트웨이 전략법을 사용하여 Ad5 아데노바이러스 유전자 모듈을 재조립하기 위한 원래의 제안을 상세하게 설명해 놓은 것이다. 이러한 특별한 전략법은 4개의 엔트리 벡터를 조합하는 것을 포함하는데, 상기 2개의 엔트리 벡터 중 3개는 아데노바이러스 유전자 모듈이었고, 4번째 것은 비관련 스터퍼 모듈이었다. 일단 상기 4개의 모듈을 조합하고 나면, 게이트웨이 반응에 의해 스터퍼 모듈을 제거함으로써 새로운 목적 벡터를 형성한다. 마지막으로, 남은 두 아데노바이러스 유전자 모듈을 게이트웨이 반응에 의해 삽입하여 바이러스 게놈을 완성한다. 이러한 원래의 제안은 게이트웨이 반응에서 보다 큰 아데노바이러스 유전자 모듈을 사용할 경우에는 비효율적이었고, 이와 함께 Ad5 E1 모듈로부터 독성에 관한 문제도 있었다. 조합 방법(예컨대, SLIC 및 SSR 방법)을 통해 더욱 용이하게 모듈로부터 게놈을 조립할 수 있었다(예컨대, 수행 단계는 감소시키고, 각 단계별 효율은 증가시켰다).

SLIC 기술은 두 핵산(예컨대, DNA 단편) 중의 엑소뉴클레아제에 의해 생성된 단일 가닥 핵산(예컨대, DNA) 오버행에 의존하여 단일 가닥 상동성 서열을 어닐링시키는 것을 사용한다(도 16). 따라서, SLIC 기술은 삽입된 핵산(예컨대, DNA) 및 목적 벡터 중의 엑소뉴클레아제에 의해 생성된 단일 가닥 핵산(예컨대, DNA) 오버행에 의존하는 상동성 재조합 및 단일 가닥 어닐링(예컨대, 하이브리드화)을 사용한다. 본원에서는 아데노바이러스 유전자 모듈을 목적 벡터로 삽입시켜 핵산(예컨대, 핵산 플라스미드)을 형성하는, SLIC 기술을 적합화시킨 방법을 제공한다. 본원에서 상기 과정은 또한 AdSlic 또는 AdSlicR로도 지칭될 수 있다. SLIC 기술의 일반 사용 방법은 예를 들어, 문헌 [Li et al., Nature Methods (2007), 4, 251-256]에 기술되어 있다. 도 25는 인간 Ad5에 대해 확립되어 있는 AdSlicR의 일례를 다이어그램으로 나타낸 것이다. 도 26은 AdSlicR 방법에서 상기 반응의 효율을 상세하게 설명해 놓은 것이다.

예를 들어, SLIC 기술(또는 유사한 클로닝 기술)이 사용될 경우, 조립 단계는 (예컨대, 각 말단 상에) 단일 가닥 핵산(예컨대, DNA) 오버행을 가지는 하이브리드화 수행 능력이 있는 목적 벡터(예컨대, 목적 벡터(예컨대, 선형 벡터))를 하나 이상의 아데노바이러스 유전자 모듈에 하이브리드화(예컨대, 어닐링)시킴으로써 아데노바이러스 유전자 모듈 벡터를 형성하는 것을 포함한다. 하이브리드화 수행 능력이 있는 목적 벡터는 또한 본원에서 SLIC 수행 능력이 있는 벡터로서도 지칭될 수 있다. 하나 이상의 아데노바이러스 유전자 모듈은 (예컨대, 엄격한 조건하에서의) 하이브리드화를 촉진시킬 수 있을 만큼 목적 벡터의 단일 가닥 핵산(예컨대, DNA) 오버행에 대해 충분한 상보성을 지닌, (예컨대, 각 말단 상에) 1 이상의 단일 가닥 핵산(예컨대, DNA) 오버행을 가지는 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈(예컨대, 아데노바이러스 유전자 모듈(예컨대, 선형 아데노바이러스 유전자 모듈))일 수 있다. 일부 실시양태에서, 목적 벡터 오버행 및 아데노바이러스 유전자 모듈 오버행의 길이는 각각 약 20 내지 25 bp이다. 하이브리드화 수행 능력이 있는 목적 벡터는 임의의 적절한 방법을 사용함으로써 형성될 수 있다.

예를 들어, 일부 실시양태에서, 목적 벡터가 환형일 경우(예컨대, 플라스미드), 목적 벡터는 (예컨대, 엔도뉴클레아제로) 절단되고, 이로써 선형 목적 벡터가 형성된다. 이어서, 선형 목적 벡터를 엑소뉴클레아제(즉, 엑소뉴클레아제 활성을 가진 효소, 예컨대, T4 DNA 폴리머라제)와 접촉시킴으로써 하이브리드화 수행 능력이 있는 목적 벡터를 형성한다. 유사하게, 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈은 아데노바이러스 유전자 모듈을 엑소뉴클레아제와 접촉시켜(예컨대, 처리하여) 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈을 형성함으로써 형성이 될 수 있다. 일부 실시양태에서, 하이브리드화 수행 능력이 있는 목적 벡터를 하나 이상의 아데노바이러스 유전자 모듈에 하이브리드화시키는 것은 하이브리드화 수행 능력이 있는 목적 벡터 및 아데노바이러스 유전자 모듈(들)을 DNA 폴리머라제와 조합시키는 것을 포함할 수 있다. 일부 실시양태에서, 아데노바이러스 유전자 모듈이 환형이거나, 또는 환형 플라스미드 내에 포함되어 있는 경우, 아데노바이러스 유전자 모듈은 엑소뉴클레아제 처리 이전에 엔도뉴클레아제로 처리함으로써 선형화된다. 따라서, 일부 실시양태에서, 하나 이상의 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈은 하나 이상의 엔트리 벡터 아데노바이러스 유전자 모듈을 포함하는 엔트리 벡터를 엔도뉴클레아제와 접촉시켜 하나 이상의 유리된(released) 엔트리 벡터 아데노바이러스 유전자 모듈을 형성함으로써 형성이 된다. 하나 이상의 유리된 엔트리 벡터 아데노바이러스 유전자 모듈을 엑소뉴클레아제와 접촉시켜 하나 이상의 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈을 형성할 수 있다. 본원에서 지칭되는 바와 같이 엔트리 벡터 아데노바이러스 유전자 모듈은 엔트리 벡터의 일부인 아데노바이러스 유전자 모듈이다. 본원에서 지칭되는 바와 같이 유리된 엔트리 벡터 아데노바이러스 유전자 모듈은 예를 들어, 제한 효소에 의해 엔트리 벡터로부터 유리된 아데노바이러스 유전자 모듈이다. 일부 실시양태에서, 아데노바이러스 유전자 모듈은 환형이 아니고(예컨대, PCR 또는 유전자 합성에 의해 수득된 것이고), 엑소뉴클레아제 처리에 앞서 선형화될 필요가 없다. 일부 실시양태에서, SLIC 수행 능력이 있는 벡터를 하나 이상의 아데노바이러스 유전자 모듈에 어닐링시키는 것은 LIC 수행 능력이 있는 벡터 및 아데노바이러스 유전자 모듈(들)을 DNA 폴리머라제와 조합시키는 것을 포함할 수 있다.

일부 실시양태에서, SLIC 수행 능력이 있는 벡터는 SLIC 수행 능력이 있는 아데노바이러스 유전자 모듈과의 어닐링 이전에 하나 이상의 아데노바이러스 유전자 모듈을 포함한다. 따라서, 일부 실시양태에서, 다중 SLIC 반응은 다중 아데노바이러스 유전자 모듈을 삽입하기 위해 순차적으로 수행된다.

일부 실시양태에서, 주형으로서 사용하고자 하는 플라스미드 중의 아데노바이러스 게놈을 수득하여 아데노바이러스 유전자 모듈을 생성하기 위해, SLIC를 사용하여 전체 아데노바이러스 게놈을 플라스미드 골격 내로 삽입할 수 있다. 일부 실시양태에서, SLIC 수행 능력이 있는 아데노바이러스 게놈은 정제된 바이러스 스톡으로부터 수득된다. 도 30은 상기 과정에 관한 실시양태를 다이어그램으로 나타낸 것으로서, 인간 Ad에 대한 일례를 제공한다.

아데노바이러스 유전자 모듈 벡터는 1 이상의 아데노바이러스 유전자 모듈을 가지는 핵산이다. 적절한 클로닝 기술을 사용하여, 원하는 개수의 아데노바이러스 유전자 모듈을 목적 벡터에 첨가함으로써 아데노바이러스 유전자 모듈 벡터를 형성한다. 예를 들어, 일단 형성되고 나면, 아데노바이러스 유전자 모듈(예컨대, 아데노바이러스 유전자 모듈 벡터)을 적절한 클로닝 기술(예컨대, 게이트웨이 클로닝 기술 및/또는 SLIC 클로닝 기술)을 사용하여 추가로 변형시킴으로써 아데노바이러스 유전자 모듈을 추가로 첨가하여 핵산을 형성할 수 있으며, 이 핵산은 (예컨대, 세포에서) 발현됨으로써 아데노바이러스(예컨대, 복제가능한 아데노바이러스)가 형성될 수 있다. 따라서, 일부 실시양태에서, 적절한 클로닝 기법을 사용하여 제1 아데노바이러스 유전자 모듈을 추가로 변형시켜 제2, 제3, 및/또는 제4의 아데노바이러스 유전자 모듈이 각각 벡터에 첨가되어 있는 것인 제2, 제3, 및/또는 제4의 아데노바이러스 모듈을 형성할 수 있고, 이로써 핵산을 형성할 수 있으며, 이 핵산은 발현되어 아데노바이러스(예컨대, 복제가능한 아데노바이러스)를 형성할 수 있다. 따라서, 일부 실시양태에서, 핵산은 아데노바이러스 유전자 모듈 벡터이다.

실제로, 상이한 클로닝 기술을 사용하여 핵산 또는 아데노바이러스 유전자 모듈 벡터를 조립할 수 있다. 일부 실시양태에서, 조립 단계는 하이브리드화 수행 능력이 있는 목적 벡터를 제1 아데노바이러스 유전자 모듈에 하이브리드화시켜((예컨대, 어닐링시켜) 제1 아데노바이러스 유전자 모듈 벡터를 형성하는 것을 포함한다. 제1 아데노바이러스 유전자 모듈은 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈일 수 있다. 제1 아데노바이러스 유전자 모듈 벡터 및 제2 아데노바이러스 유전자 모듈 엔트리 벡터를 인터그라제(예컨대, 인터그라제, 엑시지오나제, 또는 통합 숙주 인자)와 접촉시켜(예컨대, 조합하여) 제2 아데노바이러스 유전자 모듈 벡터를 형성할 수 있다. 제2 아데노바이러스 유전자 모듈 벡터는 재조합 수행 능력이 있는 제2 아데노바이러스 유전자 모듈 벡터(예컨대, 목적 벡터)일 수 있고, 제2 아데노바이러스 유전자 모듈은 재조합 수행 능력이 있는 제2 아데노바이러스 유전자 모듈일 수 있다. 일부 실시양태에서, 제1 아데노바이러스 유전자 모듈은 E2-L2 모듈, L3-L4 모듈, 또는 E2-L4 마크로모듈이다. 제2 아데노바이러스 유전자 모듈은 E1 모듈, E3 모듈, 또는 E4 모듈일 수 있다. 클로닝 방법을 조합하여 아데노바이러스 유전자 모듈을 조립하는 것에 관한 예는 SLIC를 게이트웨이와 조합한 것을 나타낸 도 20-21에 제공되어 있다.

다른 실시양태에서, 조립 단계는 재조합 수행 능력이 있는 목적 벡터 및 제1 아데노바이러스 유전자 모듈을 인터그라제(예컨대, 인터그라제, 엑시지오나제, 또는 통합 숙주 인자)와 함께(예컨대, 그의 존재하에서) 접촉시켜(예컨대, 조합하여) 제1 아데노바이러스 유전자 모듈 벡터를 형성하는 것을 포함한다. 제1 아데노바이러스 유전자 모듈은 재조합 수행 능력이 있는 제1 아데노바이러스 유전자 모듈(예컨대, 엔트리 벡터)이다. 제1 아데노바이러스 유전자 모듈 벡터를 제2 아데노바이러스 유전자 모듈에 하이브리드화시켜 제2 아데노바이러스 유전자 모듈 벡터를 형성한다. 제1 아데노바이러스 유전자 모듈 벡터는 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈 벡터(예컨대, 목적 벡터)이다. 제2 아데노바이러스 유전자 모듈은 하이브리드화 수행 능력이 있는 아데노바이러스 유전자 모듈(예컨대, 엔트리 벡터)이다. 일부 실시양태에서, 제2 아데노바이러스 유전자 모듈은 E2-L2 모듈, L3-L4 모듈, 또는 E2-L4 마크로모듈이다. 제1 아데노바이러스 유전자 모듈은 E1 모듈, E3 모듈, 또는 E4 모듈일 수 있다.

일부 실시양태에서(예컨대, 인간 Ad5의 일례에서), E2-L2 모듈 및 L3-L4 모듈은 각각 대략 14 kb 및 10 kb이다. 본원에서 제공하는 발견 내용 중 하나는 일부 실시양태에서, E2-L2 및 L3-L4 모듈의 크기가 너무 크기 때문에 표준 또는 게이트웨이(예컨대, 다중 부위 게이트웨이) 클로닝 기술을 사용하여 핵산으로 효율적으로 조립할 수 없다는 것이다. 일례는 도 15에 제공되어 있다. 따라서, 일부 실시양태에서, SLIC 클로닝 기술(또는 유사한 클로닝 기술)을 사용하여 상기 모듈을 목적 벡터(예컨대, 엔트리 벡터) 내로 삽입한다. 다른 아데노바이러스 유전자 모듈은 예를 들어, 게이트웨이 클로닝 기술의 사용으로 첨가될 수 있다. 따라서, 일부 실시양태에서, E2-L2 모듈 및 L3-L4 모듈이 핵산으로 조립될 경우, 조합된 SLIC 및 게이트웨이(예컨대, 다중 부위 게이트웨이) 클로닝 전략법을 사용하여 핵산을 조립하는 것이 바람직할 수 있다. 조합된 SLIC 및 게이트웨이(예컨대, 다중 부위 게이트웨이) 클로닝 전략법에 관한 특정 실시양태는 도 20-21에 기술되어 있다.

본원에서 제공하는 본 발명의 특정의 실시양태는 신속하고 효율적인 아데노바이러스 게놈 구성체 조리법을 제공한다. 일부 경우에, 아데노바이러스 게놈 구성체를 10, 9, 8, 7, 6, 5, 4, 3, 2, 또는 1시간(들) 미만의 시간에 조립된다. 본원에서 제공하는 본 방법을 통해 추가로 아데노바이러스 단편을 벡터 내로 삽입시킬 수 있고, 개별 벡터내에서 용이하게 독립적으로 돌연변이시킬 수 있고/거나, 다중 부위 특이 시험관내 조립을 수행할 수 있다.

일부 실시양태에서, 아데노바이러스 유전자 모듈 중 하나 또는 그 모두는 하기 기술하는 바와 같이, 재조합 아데노바이러스 유전자 모듈로 이루어진 라이브러리로부터 선택될 수 있다. 따라서, Ad셈블리 공정의 특정 실시양태를 통해 아데노바이러스 유전자 모듈의 최적의 조합에 기초하여 맞춤형 아데노바이러스 기능성을 신속하게 최적화시킴으로써 매우 다양한 재조합 아데노바이러스를 신속하고 효율적으로 구성할 수 있다. 따라서, 본 방법은 다양한 아데노바이러스 혈청형으로부터의 일부를 혼합하고 매치시킴으로써 신규한 아데노바이러스 혈청형 키메라를 형성할 수 있는 능력을 제공한다. 이를 통해 각 혈청형의 독특한 특성을 부여할 수 있도록 조합시킬 수 있을 뿐만 아니라, 혈청형의 다양한 향성을 사용할 수 있고, 우세한 혈청형에 대한 기존의 면역을 잠재적으로 회피할 수 있도록 그를 사용할 수 있다.

본원에서 제공하는 본 발명의 특정 실시양태를 통해 제한된 제한 효소 부위 클로닝 기술에 대해 의존할 필요가 없게 된다. 본 방법을 통해서는 또한 아데노바이러스 혈청형 5에 대한 배타적인 의존을 피할 수 있다. 실제로는, 인간 Ad5의 일례에서, E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 및 E4 모듈, 5개 모두가 사용될 경우, 돌연변이체 옵션은 이전 공지 방법에 비해 실질적으로 증가한다. 특정 실시양태에서, 본원에서 제공하는 본 방법을 통해 게놈을 동시에 복합적으로 변이시킬 수 있다.

본 방법을 통해서는 또한, 대개는 수개월이 소요될 수 있는, 분화된 박테리아 균주에서, 또는 포유동물 세포 배양물(예컨대, MAGIC)에서의 비효율적 상동성 재조합에 배타적으로 의존하는 것인 이전 공지된 게놈 조립법을 회피할 수 있다. 또한, 본원에서 제공하는 본 발명의 특정 실시양태는 분화된 박테리아를 사용할 필요없이 상업적으로 이용가능한 시약(예컨대, ccdB-내성)을 사용하는 간단한 프로토콜을 제공한다.

본원에서 제공하는 본 방법 및 라이브러리의 유용성은 예를 들어, 하기를 포함한다:

(1) 유전자 작용 분석을 위한 아데노바이러스 유전자의 돌연변이유발.

(2) 아데노바이러스 유전자 작용의 상실로 인해 정상 세포에서는 복제가 불가능하지만, 그의 작용이 보완되는 종양 세포에서는 선택적 용해 복제가 이루어지는 아데노바이러스 돌연변이체.

(3) 복제 결함이 있는 벡터 또는 복제 수행 능력이 있는 바이러스로서의 표적화된 유전자 발현.

(4) 본 방법은 유전자 발현용의 신규한 복제 결함이 있는 아데노바이러스를 제공할 수 있다. 본원의 방법을 사용하여 조립된 아데노바이러스는 상기 목적을 위해 최적화될 수 있다. 인간 Ad5의 경우, E1 모듈의 라이브러리는 예를 들어, 수개의 E1A 또는 E1B 결실 모듈을 포함할 수 있고/거나, 각각은 상이한 포유동물 프로모터를 포함함으로써 사용자가 최상의 프로모터를 선택할 수 있도록 하여 관심의 대상이 되는 유전자를 발현시킬 수 있다.

(5) 아데노바이러스 게놈의 현존 전사 구조를 사용하는 다중유전자 발현.

일부 실시양태에서, 각각의 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 및 E4 모듈이 사용될 경우, 돌연변이는 오직 E4 모듈에만 존재하지 않는다.

E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 ?? 그의 마크로모듈은 임의의 적절한 방법(예컨대, PCR 기법 또는 유전자 합성)을 사용하여 임의의 적절한 아데노바이러스로부터 유래될 수 있다. 예를 들어, 정제된 바이러스로부터 수득된 바이러스 게놈 DNA로부터의 PCR(도 14)을 사용할 수 있다. 도 13은 인간 Ad5 아데노바이러스 유전자 모듈에 대해 얻은 PCR 효율을 상세하게 나타낸 것이다. 일부 실시양태에서, E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, 및 E4 모듈의 조합, 또는 그의 마크로모듈은 완전한, 또는 실질적으로 완전한 아데노바이러스 게놈을 구성한다. 본원에서 제공하는 교시를 사용하면, 당업계의 숙련가는 모듈 사이의 절단부의 정확한 위치를 결정할 수 있다. 예를 들어, 생물정보학적 접근법을 사용함으로써 재조합 부위 핵산 서열에 대한 최적의 삽입 부위(예컨대, 게이트웨이 재조합 신호 또는 게이트웨이 재조합 부위)를 결정할 수 있다. 수개의 아데노바이러스 혈청형을 정렬할 수 있고, 아데노바이러스 유전자 모듈 사이의 게놈 영역을 보존성에 대하여 분석할 수 있다. 일부 실시양태에서, 혈청형간의 뉴클레오티드 보존성은 회피되는 반면, 축퇴성 영역은 허용되는 삽입 부위이다. 예를 들어, 인간 Ad5에서 재조합 부위 핵산 서열에 대한 삽입 부위로서 특정의 적절한 위치는 도 12, 도 35, 도 36, 도 37 및 도 38에서 화살표로 표시되어 있다.

일부 실시양태에서, 아데노바이러스 유전자 모듈 사이의 서열은 단쇄일 수 있고, 이로써 서열 복제가 필요할 수 있다. 그 예는 도 12에 제공되어 있는데, 여기서, Ad5 섬유 폴리A 및 E4 폴리A 사이의 서열량이 부족하기 때문에, Ad5 서열의 27 bp의 중복부를 attB 부위 삽입과 함께 삽입하였다.

일부 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 하나 이상의 재조합 부위 핵산 서열을 포함한다. 도 35-39에는 제한하고자 하는 것은 아니지만, 재조합 아데노바이러스 내의 재조합 부위 핵산 서열의 핵산 서열 위치가 재조합 아데노바이러스의 성장 속도에 어떻게 영향을 미치는지를 나타내는 것에 관한 일례가 개시되어 있다. 따라서, 일부 실시양태에서, 하나 이상의 재조합 부위 핵산 서열(예컨대, att 부위)을 포함하는 재조합 아데노바이러스는 하나 이상의 재조합 부위 핵산 서열을 포함하지 않는 재조합 아데노바이러스보다 더 느리게 성장할 수 있다. 다른 실시양태에서, 하나 이상의 재조합 부위 핵산 서열(예컨대, att 부위)을 포함하는 재조합 아데노바이러스는 적어도, 하나 이상의 재조합 부위 핵산 서열을 포함하지 않는 재조합 아데노바이러스 만큼 빠르게 성장할 수 있다. 다른 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 E3 모듈 및 E4 모듈 사이에 재조합 부위 핵산 서열을 포함한다. 일부 실시양태에서, E3 모듈 및 E4 모듈 사이의 재조합 부위 핵산 서열은 attB3 재조합 부위 핵산 서열이다. 일부 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 서열 번호: 137에 기술된 뉴클레오티드 32904 또는 그의 상동체 중의 등가의 뉴클레오티드 다음에 재조합 부위 핵산 서열을 포함한다. 다른 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 E1 모듈 및 E2-L2 모듈 사이에 재조합 부위 핵산 서열을 포함한다. 다른 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 서열 번호: 137에 기술된 뉴클레오티드 4035 또는 그의 상동체 중의 등가의 뉴클레오티드 다음에 재조합 부위 핵산 서열을 포함한다. 다른 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 서열 번호: 137에 기술된 뉴클레오티드 3608 또는 그의 상동체 중의 등가의 뉴클레오티드 다음에 재조합 부위 핵산 서열을 포함한다. 일부 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 L3-L4 모듈 및 E3 모듈 사이에 재조합 부위 핵산 서열을 포함한다. 일부 실시양태에서, L3-L4 모듈 및 E3 모듈 사이의 재조합 부위 핵산 서열은 attB5 재조합 부위 핵산 서열이다. 다른 실시양태에서, 핵산(예컨대, 아데노바이러스 유전자 모듈 벡터)은 E1 모듈 및 E2 모듈 사이에 제1 재조합 부위 핵산 서열을, L3-L4 모듈 및 E3 모듈 사이에 제2 재조합 부위 핵산 서열을, 및 E3 모듈 및 E4 모듈 사이에 제3 재조합 부위 핵산 서열을 포함한다. 다른 실시양태에서, 제1 재조합 부위 핵산 서열은 핵산 중 서열 번호: 137에 기술된 뉴클레오티드 4035 또는 그의 상동체 중의 등가의 뉴클레오티드 다음에 포함되어 있고, 제3 재조합 부위 핵산 서열은 핵산 중 서열 번호: 137에 기술된 뉴클레오티드 32904 또는 그의 상동체 중의 등가의 뉴클레오티드 다음에 포함되어 있다.

Ad5 게놈(서열 번호: 137) 내로의 4개의 삽입을 보여주는, 시행된 삽입 전략법의 일례가 하기에 열거되어 있다. 번호는 공개된 Ad5 게놈 서열 내의 뉴클레오티드 위치를 나타내는 것으로서, 여기서, 삽입 부위는 재조합 부위 핵산 서열의 삽입을 위해 위치하는 것이다. 하기 일례에서, attB 서열(즉, 재조합 부위 핵산 서열)은 밑줄로 표시되어 있고, 최종 삽입을 위한 Ad5 서열 중의 중복부는 굵게 표시되어 있다. 당업계의 숙련가는 유사한 콘텐츠 또는 상동성 바이러스 서열 중의 적절하고/거나 등가의 삽입 부위를 바로 이해할 수 있을 것이다.

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도 21의 조립 전략법을 17회 사용하여 감염성 인간 Ad5 바이러스를 수득하였다. 도 24에는 본원에서 제공하는 본 발명의 효율이 상세하게 설명되어 있다. 4회에 걸쳐 야생형 Ad셈블링된 아데노바이러스를 세포에 형질감염시키고, 바이러스를 생산하였다. 추가로, 상기 프로토콜을 통해 13개의 돌연변이체 아데노바이러스가 생성되었고, 그들 모두 감염성 바이러스를 생산하였다. 도 27은 단일 플라크로서 형질감염으로부터 얻은 재조립된 야생형 Ad5, 및 또한 293 세포 상에 계대접종된 것에 관한 영상을 제공한다. 도 20-21 및 도 25의 전략법으로부터 생산된 바이러스를 도 28에 제시된 바와 같이, 293 세포에서의 복제 효율에 대하여 테스트하였다.

또 다른 측면에서, 본원에 개시된 방법에 의해 제조된 아데노바이러스를 제공한다. 일부 실시양태에서, 아데노바이러스는 복제 수행 능력이 있는 것이다. 또 다른 실시양태에서, 아데노바이러스는 복제 수행 능력이 없는(replication incompetent) 것이다.

II. 아데노바이러스 유전자 모듈 및 마크로모듈 라이브러리

또 다른 측면에서, 복수개의 아데노바이러스 유전자 모듈(예컨대, 마크로모듈)을 포함하는 라이브러리를 제공한다. 일부 실시양태에서, 라이브러리는 복수개의 상이한 E1 모듈을 포함한다. 다른 실시양태에서, 라이브러리는 복수개의 상이한 E2-L2 모듈을 포함한다. 다른 실시양태에서, 라이브러리는 복수개의 상이한 L3-L4 모듈을 포함한다. 다른 실시양태에서, 라이브러리는 복수개의 상이한 E3 모듈을 포함한다. 다른 실시양태에서, 라이브러리는 복수개의 상이한 E4 모듈을 포함한다. 다른 실시양태에서, 라이브러리는 복수개의 상이한 코어 마크로모듈을 포함한다. 일부 실시양태에서, 아데노바이러스 게놈 라이브러리는 상기 기술된 방법에 따라 제조된다.

다른 실시양태에서, 라이브러리는 복수개의 상이한 E1 모듈, 복수개의 상이한 E2-L2 모듈, 복수개의 상이한 L3-L4 모듈, 복수개의 상이한 E3 모듈, 복수개의 상이한 E4 모듈, 및/또는 복수개의 상이한 코어 마크로모듈을 포함한다. 일부 실시양태에서, 라이브러리는 복수개의 상이한 마크로모듈을 포함하는데, 여기서, 마크로모듈은 복수개의 상이한 E1-L2 마크로모듈, 복수개의 상이한 E2-L4 마크로모듈(즉, 코어 마크로모듈) 및/또는 복수개의 상이한 E3-E4 마크로모듈을 포함한다.

일부 실시양태에서, 복수개의 상이한 아데노바이러스 유전자 모듈 및/또는 마크로모듈은 그들이 상이한 유형의 아데노바이러스(예컨대, 상이한 종 또는 상이한 혈청형)로부터 유래되었다는 점에서 상이한 것이다. 예를 들어, 일부 실시양태에서, 복수개의 상이한 E1 모듈, 복수개의 상이한 E2-L2 모듈, 복수개의 상이한 L3- L4 모듈, 복수개의 상이한 E3 모듈, 복수개의 상이한 E4 모듈, 및/또는 복수개의 상이한 마크로모듈(예컨대, 코어 마크로모듈)은 복수개의 아데노바이러스 유형(예컨대, 1 초과의 인간 아데노바이러스 혈청형)으로부터 유래된 아데노바이러스 유전자 모듈을 포함한다.

일부 실시양태에서, 복수개의 상이한 아데노바이러스 유전자 모듈 및/또는 마크로모듈은 그들이 상이한 돌연변이체 모듈 또는 마크로모듈(예컨대, 결실된 아데노바이러스 핵산 서열, 치환된 아데노바이러스 핵산 서열, 이소성 아데노바이러스 핵산 서열, 또는 비아데노바이러스 유전자 생성물을 코딩하는 핵산 서열)을 코딩한다는 점에서 상이한 것이다. 예를 들어, 라이브러리는 결실된 아데노바이러스 핵산 서열, 치환된 아데노바이러스 핵산 서열, 이소성 아데노바이러스 핵산 서열, 또는 비아데노바이러스 유전자 생성물을 코딩하는 핵산 서열을 비롯한, 복수개의 상이한 E1 모듈, 복수개의 상이한 E2-L2 모듈, 복수개의 상이한 L3-L4 모듈, 복수개의 상이한 E3 모듈, 복수개의 상이한 E4 모듈, 또는 복수개의 상이한 마크로모듈(예컨대, 코어 마크로모듈)을 포함할 수 있다.

일부 실시양태에서, 복수개의 상이한 아데노바이러스 유전자 모듈 및/또는 마크로모듈은 재조합 수행 능력이 있는(예컨대, 엔트리 벡터 내에 포함되어 있는) 것이다. 예를 들어, 라이브러리는 재조합 수행 능력이 있는, 복수개의 상이한 E1 모듈, 복수개의 상이한 E2-L2 모듈, 복수개의 상이한 L3-L4 모듈, 복수개의 상이한 E3 모듈, 복수개의 상이한 E4 모듈, 및/또는 복수개의 상이한 E2-L4 마크로모듈 모듈을 포함할 수 있다.

일부 실시양태에서, 복수개의 상이한 아데노바이러스 유전자 모듈 및/또는 마크로모듈은 하이브리드화 수행 능력이 있는(예컨대, SLIC 수행 능력이 있는, 예컨대, 선형화 이후에 SLIC 수행 능력이 있는) 것이다. 예를 들어, 일부 실시양태에서, 라이브러리는 하이브리드화 수행 능력이 있는, 복수개의 상이한 E1 모듈, 복수개의 상이한 E2-L2 모듈, 복수개의 상이한 L3-L4 모듈, 복수개의 상이한 E3 모듈, 복수개의 상이한 E4 모듈, 및/또는 복수개의 상이한 E2-L4 마크로모듈을 포함한다.

본원에서 제공하는 라이브러리의 일부는 다른 사용자가 생성할 수 있고, 다른 사용자 간에 공유할 수 있다. 다양한 아데노바이러스 유전자 모듈을 혼합하고, 매치시킴으로써 원하는 기능성을 가진, 또는 기능성이 없는 신규한 아데노바이러스 구성체를 구성할 수 있다. 따라서, 본원의 방법 및 라이브러리는 다양한 아데노바이러스 혈청형으로부터의 일부를 혼합하고 매치시킴으로써 신규한 아데노바이러스 혈청형 키메라를 형성할 수 있는 능력을 제공한다. 아데노바이러스 유전자 모듈의 라이브러리는 그의 이상적인 아데노바이러스 벡터 구성을 위한 다중의 옵션을 사용자에게 제공한다.

일부 실시양태에서, 아데노바이러스 유전자 모듈은 박테리아에 대해 독성을 띨 수 있다. 예를 들어, 도 18은 인간 Ad5 E1 모듈의 독성을 입증하는 것이다. 일부 실시양태에서, 보다 낮은 카피수로 유지되는 아데노바이러스 유전자 모듈(예컨대, p15A 복제 기점)은 플라스미드 내에 포함되어야 있어야 할 수도 있다.

일부 실시양태에서, SSR 방법(예컨대, 게이트웨이 반응)에서 아데노바이러스 유전자 모듈 독성, 크기, 또는 다른 인자가 그의 사용을 방해할 수 있다. 예를 들어, 도 15에는 5개의 인간 Ad5 아데노바이러스 유전자 모듈에 대한 표준 게이트웨이 BP 반응 효율이 상세하게 설명되어 있다. 일부 실시양태에서, SSR 방법(예컨대, 게이트웨이 반응)을 사용하였을 때 비효율적인 아데노바이러스 유전자 모듈은 대체 클로닝 방법(예컨대, SLIC)에 의해 조작될 수 있다. 도 17은 엔트리 벡터를 생성하기 위해 (예컨대, 게이트웨이 클로닝 효소를 사용하는) SSR 방법 대신 SLIC 를 사용하는 전략법에 관한 것을 다이어그램으로 나타낸 것이다.

III. 키트

또 다른 측면에서, E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈, 또는 아데노바이러스 마크로모듈(또는 하기 기술하는 바와 같은 그의 돌연변이체)로부터 선택되는 2개 이상의 아데노바이러스 유전자 모듈을 포함하는 핵산을 포함하는, 본원에서 제공하는 본 방법 및 라이브러리에서 사용하기 위한 키트를 제공한다. 키트의 적절한 구성 성분은 상기 섹션 I 및/또는 II에서 논의된 조성물 및 구성 성분을 포함한다.

예를 들어, 일부 실시양태에서, 키트는 E1 모듈, E2-L2 모듈, L3-L4 모듈, E3 모듈, E4 모듈 또는 아데노바이러스 마크로모듈로부터 선택되는 3, 4, 또는 5개의 아데노바이러스 유전자 모듈을 포함하는 핵산을 포함할 수 있다. 핵산은 상기 논의된 바와 같은 벡터(예컨대, 플라스미드)(예컨대, 목적 벡터 또는 도너 벡터)의 일부를 형성할 수 있다.

일부 측면에서, 본원에서 제공하는 키트는 아데노바이러스 유전자 모듈을 포함하거나, 포함하지 않는 벡터를 포함할 수 있다. 키트에서 유용한 키트는 하나 이상의 재조합 부위 핵산 서열 및/또는 단일 가닥 핵산 오버행(또는 적절한 효소와의 접촉시 단일 가닥 핵산 오버행을 형성할 수 있는 핵산 서열)을 포함할 수 있다. 일부 실시양태에서, 벡터는 상기 기술된 바와 같은 하이브리드화 수행 능력이 있는 목적 벡터, SLIC 수행 능력이 있는 벡터 또는 도너 벡터이다. 벡터는 하나 이상의 아데노바이러스 유전자 모듈을 포함할 수 있다. 일부 실시양태에서, 벡터는 역선택 카세트를 포함한다.

본원에서 제공하는 본 방법을 수행하기 키트의 추가의 구성 성분(예컨대, 엑소뉴클레아제, 인터그라제, 프로모터 서열 등)은 본 발명의 Ad셈블리 방법 및 라이브러리에 관한 설명과 관련하여 쉽게 자명해질 것이다.

IV. 실시예

하기 실시예는 청구되는 본 발명을 제한하고자 하는 것이 아니라, 설명하기 위해 제공되는 것이다.

A. 바이러스 조립 방법

1. 차세대 바이러스 벡터 및 복제 용해 암 요법 개발을 위한 화학법 '조합' 및 바이러스 게놈 '재조합'

본 발명자들은 다중 변형 및 이종성 요소가 체계적으로 조합될 수 있도록 허용하는, 구성 성분 일부로부터의 바이러스 게놈의 신속하고 새로운 조립을 위한 유용한 재조합 전략법을 개발하였다.

여러 적용에서 아데노바이러스 벡터의 잠재적 능력은 다중 유전자 변형을 빠르고 체계적으로 조작하고 조합할 수 있는 능력으로 인해 저지되었다. 주로 사용되는 주된 방법은 게놈 중 적절한 위치에서의 적합한 제한 효소 부위의 독특한 이용가능성에 따라 달라지고, 일반적으로는 체계적인 사용을 따르지 않거나, 신속한 단일 단계로 정확한 복합 변형을 일으킨다. 거대 게놈 DNA 단편의 조작 및 독특한 제한 부위의 부족으로 인해 상기 방법은 기술상 도전 과제가 되었으며, 한계에 이르게 되었다. 또 다른 방법에서는 변형시키고자 하는 게놈 영역을 포함하는 보다 작은 '셔틀' 벡터, 및 바이러스 게놈을 포함하는 '골격(backbone)' 벡터를 생성하여야 한다. 이러한 벡터의 경우 주요 속도 제한 단계는 재조합인데, 이는 포유동물 세포에서의 상동성 재조합에 의해(이는 빈도가 극도가 낮은 이벤트이며, 무작위 부위에서 발생하고, 원하는 재조합체를 단리시키기 위해서는 다회에 걸친 플라크 정제가 수행되어야 한다), 또는 특별한 박테리아 균주에서의 상동성 재조합에 의해 발생한다. 이러한 방법에는 한계가 있다.

현 기술의 한계를 극복하기 위해, 본 발명자들은 밤새도록 복합 바이러스 돌연변이체를 신속하고 체계적으로 생성할 수 있는 신규한 아데노바이러스 게놈 조립 전략법을 개발하였다. 이러한 전략법을 통해 포유동물 세포에서의 비효율적이고 부정확한 재조합, 이용가능한 BAC 또는 셔틀 벡터에 대한 필요성, 시간이 소비되고, 힘이 드는 플라크 정제는 수행할 필요가 없다. 상기 전략법은 1) 바이러스 유전자에 대한 다중 돌연변이/변형, 2) 다른 바이러스 서브유형으로부터의 유전자, 예컨대, 상이한 수용체에 결합하고, 혈청형을 교환하는 바이러스 코트 단백질, 3) 이소성 유전자, 예컨대, 강력한 종양 방관자 효과를 유도하는 프로드럭 전환 효소, 4) 생체내 영상화 및 진단을 위한 형광성 리포터 또는 태그 첨가, 및 5) 지정된 시험관내 바이러스 진화를 비롯한, 구성 성분 일부로부터 신속하게 신규의 바이러스 게놈을 시험관내에서 조립할 수 있는 능력을 제공한다. 추가로, 상기 기술은 인간 Ad5의 경우, 36개의 유전자를 코딩하는(스플라이스 변이체 미포함) 천연 바이러스 전사 구조를 이용하며, 이로써 아데노바이러스 감염을 통해 다중 단백질 복합체 및 전체 경로가 조립될 수 있고, 전달될 수 있고, 공발현될 수 있다.

Ad2/5 및 현 방법이 가진 한계를 극복하기 위해, 본 발명자들은 게놈 구성 성분 일부와 이종성 요소로부터 아데노바이러스 게놈을 시험관내에서 신속하게 새로 조립될 수 있는 Ad셈블리 방법을 개발하였다. 생물정보학적 접근법을 사용하여, 본 발명자들은 진화적으로 보존되는 서열, 전사 및 작용상 모듈에 기초하여 상이한 아데노바이러스 게놈(36-38 kb)을 5개의 유니트로 나누었다. 이들 5개의 유니트는 각각 "일부 라이브러리"을 구성하는 게놈의 화합성 부분을 포함하고, 그의 작용 및 다양성은 돌연변이 또는 이종성 요소의 공학처리를 통해 변경되고, 이질성 아데노바이러스 혈청형, 돌연변이체 및 종으로부터의 등가인 유니트를 첨가함으로써 추가로 확장된다. 독특한 특성을 가진 새로운 아데노바이러스를 생성하기 위해, 각 유니트들은 하나씩 라이브러리로부터 선택되고, 시험관내에서 Ad셈블리(예컨대, Ad-SlicR)를 사용함으로써 신속하게 완전한 게놈으로 재조립된다. Ad셈블리를 사용하여 다중-부위 특이 재조합을 통해 신규한 게놈을 조립할 수 있고, 이는 형질감염시, 플라스미드 골격으로부터 자가 절제되고, 복제됨으로써 신규한 바이러스를 생산하게 된다. Ad-SlicR은 (필요한 경우) 보다 강력한 바이러스 복제 및 임상적 용도를 위해 삽입된 재조합 서열을 삭제시키는 데 사용될 수 있는 전략법이다. 본원에 개시된 전략법은 Ad2/5에 대해 상이한 향성 및 다른 바람직한 특성을 가지거나, 변경된 기능성을 부여하도록 유전적으로 변형된 인간 및/또는 동물 아데노바이러스로부터 생성된 라이브러리 게놈 구성 블록을 사용할 수 있다.

이를 달성하기 위해, 본 발명자들은 '게이트웨이'로도 알려져 있는, 특이성 및 효능이 개선되어 있는 변형된 λ 파지 부위 특이 재조합 시스템을 사용하였다. 상이한 파지 효소에 의해 재조합되는 재조합 부위에는 attB, attP, attL, 및 attR로 불리는 4가지 부류가 존재한다. 최근, 신규한 att 부위 특이성이 확인되었고, 이를 통해 정의된 순서 및 배향으로 다중 DNA 단편을 동시에 재조합을 할 수 있게 되었다. 본원에서는 게놈 구성 성분 일부로부터 신규한 전체 바이러스 게놈을 조립할 수 있는 상기 시스템의 새로운 적용을 개시한다. 놀랍게도, 상기 기술은 아데노바이러스 벡터의 개발 및 잠재적인 적용에 있어서 일대의 혁신을 일으켰다.

(1-6번으로 번호매김된) attB 부위의 독특한 쌍을 도입하는 프라이머 세트를 사용하여 매치되는 인접한 기 중의 바이러스 게놈을 증폭시켰다. Ad5 아데노바이러스 게놈은 36 kb이고, 이는 일시적으로는 '조기'(E: early) 및 '후기'(L: late) 전사 유니트로 나뉘는데, 이는 함께 36-40개의 유전자를 코딩한다.

야생형 Ad5/2, Ad5/2의 돌연변이체 및 이질성 아데노바이러스 서브타입 또는 동물 바이러스를 DNA 주형으로서 사용하였다. PCR 단편을 '엔트리' 벡터 내로 재조합하여 아데노바이러스 게놈의 구성 요소를 가진 라이브러리를 생성하였다. 목적 벡터로의 LR 재조합은 개별 요소를 신규한 바이러스 게놈으로 다중 치환 방식으로 조립한다(도 1B). 이는 목적 벡터의 항생제 내성에 대한 양성 선택, 및 독성 유전자에 의해 제공되는, E. 콜라이에서의 비반응 목적 벡터의 음성 선택에 의해 촉진된다(문헌 [Hartley et al., 2000]). 단편의 개수 또는 크기가 재조합 효율을 제한하는 경우, 중간 목적 벡터가 생성되고, 여기서, 제2 BP/LR 반응으로 모듈의 치환 또는 완전한 조립이 이루어진다. 상기와 같이 신속하고 신규한 바이러스 DNA 조작 방법은 DNA 재조합 본래의 화학적 성질을 이용함으로써 신규한 바이러스의 조작을 변환시킨다.

예를 들어, CD46 세포 수용체에 결합하고, Ad2/5 바이러스에 대해 생산된 중화 항체를 회피하는 아데노바이러스 34 섬유와 같이, 추가 조합이 통합된다.

2. 물질 및 방법

상기 가이드라인을 사용하여 하기의 참조 구성 성분을 이용함으로써 변형된 아데노바이러스를 제조하였다. 게이트웨이 DONR 벡터를 사용하였다. 인간 Ad5의 일례에서, PCR에 의해 E1 모듈을 수득하고, SLIC를 사용하여 상기 E1 모듈을 벡터 pDONR P1P4 내로 삽입하였다. attL1 및 attL4 재조합 부위를 포함하는 pDONR P1P4 벡터 골격을 PCR을 사용하여 증폭시키고, SLIC에 의해 Ad5 E1 모듈과 함께 조합하였다. 대체 역선택 카세트를 생성하기 위해, 벡터 pDONR P1P4를 변형시켰다. attP1 및 attP4 재조합 부위를 포함하는 상기 벡터 골격을 PCR을 사용하여 증폭시키고, PheS^A294G 돌연변이 및 테트라사이클린 내성 카세트(pENTR L3-pLac-Tet-L2로부터의 pLac-Tet 카세트)와 조립함으로써 새로운 DONR 벡터를 생성하였다. 이어서, 새로운 DONR 벡터로부터 attR1-PheS^A294G-Tet(r)-attR4 단편을 PCR에 의해 증폭시키고, Ad셈블리 DEST 벡터 내로 삽입하였다. 문헌 (["MultiSite Gateway® Pro Plus", Cat# 12537-100]; 및 [Sone, T. et al. J Biotechnol. 2008 Sep 10; 136(3-4): 113-21])을 참조할 수 있다.

인간 Ad5의 일례에서, 게이트웨이 BP 반응에 의해 E3 모듈을 pDONR P5P3r 벡터 내로 삽입하였다. 게이트웨이 BP 반응에 의해 E4 모듈을 pDONR P3P2 벡터 내로 삽입하였다. pDONR P5P2 벡터로부터 attR5-ccdB-Cm(r)-attR2 단편을 PCR에 의해 증폭시키고, Ad셈블리 DEST 벡터 내로 삽입하였다. 문헌 (["MultiSite Gateway® Pro Plus", Cat# 12537-100]; 및 [Sone, T. et al. J Biotechnol. 2008 Sep 10;136(3-4): 113-21])을 참조할 수 있다.

Ad셈블리 DEST 벡터에 대한 벡터 골격은 3개의 상이한 공급원으로부터의 일부분으로 구성되어 있다. Amp(r) 카세트 및 lacZ 유전자를 플라스미드 pUC19로부터 증폭시켰다. 이를, 바이오브릭시GEM 2007(BioBricksiGEM 2007) 부품 유통의 일부인 플라스미드 pSB3K5-I52002로부터 수득된 p15A 복제 기점과 조합하였다. 보다 낮은 (10-12개) 카피수로 플라스미드를 유지시키는 p15A ori는 E1 독성을 감소시키는 데 필요하다. 마지막으로, 자가 절제 바이러스를 생성하기 위해 효소 I-SceI에 대한 포유동물 발현 카세트에 대해 플라스미드 pAdZ5-CV5-E3+로부터 PCR을 수행하였다. 상기 카세트를 벡터 골격으로 클로닝하여 p15A-SceI로 명명되는 벡터를 생성하였다. 이는 게놈 조립을 개시하는 데 사용되는 벡터이다. 인간 Ad5의 일례에서, 유전자 모듈을 모두 야생형 Ad5 바이러스로부터의 DNA 또는 플라스미드 pAd/CMV/V5/DEST(인비트로겐(Invitrogen))로부터 수득하였다.

인간 Ad5의 일례에서, DEST 벡터와 관련하여, E2 및 L3 모듈을 3-단편 SLIC에 의해 플라스미드 p15A-SceI 내로 삽입하였다. attR5 및 attR2 부위 측면에 위치하는, ccdB 및 Chlor(r)을 발현하는 역선택 마커는 플라스미드 pDONR P5P2로부터 PCR에 의해 수득하였다. 제2 역선택 마커(PheS-Tet)는 벡터 pDONR P1P4 PheS^A294G-Tet로부터 PCR에 의해 수득하였다(상기 참조). E2 및 L4 모듈의 말단에 대해 공학처리된 독특한 제한 효소를 사용하여 절단한 후, 2개의 역선택 마커를 SLIC에 의해 p15A-SceI E2-L4의 우측(ccdB/Cm) 및 좌측(PheS/Tet) 상에 삽입하여 DEST 벡터를 생성하였다.

인간 Ad5의 일례에서, 아데노바이러스 유전자 모듈을 포함하는 다중 부위 게이트웨이 엔트리 벡터와 관련하여, E1 모듈을 SLIC에 의해 pDONR P1P4 내로 삽입하였다. E3 모듈을 게이트웨이 BP 반응에 의해 pDONR P5P3R 내로 삽입하였다. E4 모듈을 게이트웨이 BP 반응에 의해 pDONR P3P2 내로 삽입하였다.

Amp(r) 카세트: 플라스미드 pUC19와 관련하여, p15A ori: 플라스미드 pSB3K5-I52002는 바이오브릭시GEM 2007 부품 유통의 일부였다. 아데노바이러스 아데노바이러스 유전자 모듈과 관련하여, 이는 Ad5 입자로부터 정제된 DNA 또는 플라스미드 pAd/CMV/V5/DEST(인비트로겐)로부터의 것이었다. DONR 벡터 pDONR P1P4, P5P2, P5P3R, P3P2를 존 체스넛(Jon Chesnut)(인비트로겐)으로부터 입수하였다. DH5 알파 박테리아 게놈 DNA으로부터 PheS 유전자를 유도시킨 후, 신속 변이에 의해 돌연변이시킴으로써 PheS^A294G 돌연변이체를 생성하였다. Tet(r) 유전자와 관련하여, 플라스미드 pENTR L3-pLac-Tet-L2를 존 체스넛(인비트로겐)으로부터 입수하였다.

Ad셈블리 방법의 실시양태와 관련하여, 전형적으로는 두 역선택 카세트 측면에 위치하는 코어 모듈을 포함하는 이중 DEST 벡터 20 fmol을 유전자 모듈을 포함하는 각각의 남은 엔트리 벡터 10 fmol과 조합하였다. Ad5의 일례에서, 이는 20 fmol의 E2-L3 이중 DEST 벡터를 10 fmol의 각 E1 모듈 엔트리 벡터, E3 모듈 엔트리 벡터, 및 E4 모듈 엔트리 벡터와 조합하는 것을 포함하였다. 일부 경우에, 하나 이상의 엔트리 벡터의 양을 증가시키면 (예컨대, Ad5에 대한 E1 모듈 엔트리 벡터 50 fmol을 사용하여) 효율을 증가시킬 수 있었다. 상기 벡터를 최종 부피 10 ㎕로 2 ㎕의 LR 클로나제(Clonase) II(인비트로겐)와 함께 조합하였다. 반응물을 25℃에서 밤새도록(12-16시간 동안) 인큐베이션시켰다. 1 ㎕의 프로테이나제 K(인비트로겐)를 첨가하고, 37℃에서 10분 동안 인큐베이션시킴으로써 반응을 종결시켰다. 이어서, 5 ㎕의 반응물을 ccdB 유전자 생성물에 대해 감수성인 고도한 수행 능력을 가진 박테리아(>1e9 cfu/㎍)로 형질전환시키고, YEG-C1 아가 플레이트(문헌 [Kast, P. Gene, 138 (1994) 109-114]에 기술되어 있는 것; PheS^A294G 역선택을 사용하는 경우), 또는 벡터에서 사용되는 역선택을 위해 적절한 다른 배지 상에 플레이팅시켰다. 이어서, 콜로니를 단리시키고, 완전한 게놈에 대해 스크리닝하였다.

PCR과 관련하여, 모든 PCR은 퓨전(Phusion) 효소(NEB)를 사용하여 수행하였다. Ad5로부터 아데노바이러스 유전자 모듈을 수득하기 위해 1x HF 버퍼, 200 μM의 각 dNTP, 0.5 μM의 각 프라이머, 및 10 ng의 주형을 이용하여 PCR을 수행하였다. E2-L2 모듈의 경우, 3% DMSO도 또한 첨가하였다. 주형은 플라스미드 pAd/PL-DEST(인비트로겐; E2-L2, L3-L4, 및 E4 모듈인 경우) 또는 Ad5 게놈 DNA(E1 및 E3 모듈인 경우)였다. PCR 조건은 하기와 같았다. E2-L2 및 L3-L4: 98℃에서 30 초 - 98℃에서 10 초, 65℃에서 30 초(매 2 사이클마다 온도를 1℃씩 강하시킴), 72℃에서 7 분인 것으로 10 사이클 - 98℃에서 10 초, 60℃에서 30 초, 72℃에서 8 분인 것으로 29 사이클 - 72℃에서 10 분 - 4℃에서 유지. E3: 98℃에서 30 초 - 98℃에서 10 초, 70℃에서 30 초(매 사이클마다 온도를 0.5℃씩 강하시킴), 72℃에서 2분 30초인 것으로 10 사이클 - 98℃에서 10 초, 68℃에서 30 초, 72℃에서 2분 30초인 것으로 25 사이클 - 72℃에서 10분 - 4℃에서 유지. E4: 98℃에서 30초 - 98℃에서 10초, 63℃에서 30초(매 사이클마다 온도를 0.5℃씩 강하시킴), 72℃에서 2분인 것으로 6 사이클 - 98℃에서 10초, 60℃에서 30초, 72℃에서 2분인 것으로 29 사이클 - 72℃에서 5분 - 4℃에서 유지.

정제된 바이러스로부터 바이러스 게놈 DNA를 수득하는 것과 관련하여, 최대 100 ㎕의 정제된 바이러스를, 10 mM 트리스(Tris)(pH 8), 5 mM EDTA, 200 mM NaCl, 및 0.2% SDS를 함유하는 300 ㎕의 용해 버퍼에 첨가하였다. 믹스를 60℃에서 5 min 동안 인큐베이션시킨 후, 5 ㎕의 프로테이나제 K 스톡(~20 mg/mL)을 첨가하고, 60℃에서 1시간 동안 추가로 인큐베이션시켰다. 이어서, 시료를 5 min 동안 얼음상에 놓은 후, 15 min 동안 15K x g로 회전시켰다. 상청액을 제거하고, 동량의 이소프로판올에 첨가하고, 잘 혼합하고, 4℃에서 15 min 동안 15K x g로 회전시켰다. 펠릿을 70% 에탄올로 세척하고, 4℃에서 15 min 동안 다시 회전시켰다. 펠릿을 건조시키고, 사용을 위해 재현탁시켰다.

SLIC와 관련하여, 선형 단편을 하기 20 ㎕의 반응물: 50 mM 트리스(pH 8), 10 mM MgCl₂, 50 ㎍/mL BSA, 200 mM 우레아, 5 mM DTT, 및 0.5 ㎕ T4 DNA 폴리머라제 중 실온에서 20분 동안 엑소뉴클레아제로 처리하였다. 1 ㎕의 0.5M EDTA를 첨가한 후, 75℃에서 20분 동안 인큐베이션시켜 반응을 종결시켰다. 이어서, T4로 처리된 동량의 DNA를 새 튜브에서 약 20 ㎕ 부피로 혼합하였다. 2개의 단편을 조합하는 SLIC의 경우, 각 반응물을 10 ㎕씩 사용하였다. 3개의 단편을 조합하는 SLIC의 경우, 각 반응물을 7 ㎕씩 사용하였다. 10 min 동안 65℃로 가열한 후, 매 5초마다 온도를 0.5℃씩 강하시켜 25℃가 될 때까지 천천히 냉각시켜 어닐링시켰다. 어닐링 후, 5 ㎕의 반응물을 형질전환시키고, 클론을 스크리닝하였다.

예를 들어, Ad5의 AdSlicR과 관련하여, 100 ng의 (PCR에 의해 선형화된) T4로 처리된 p15A-SceI, 및 E2 및 L3 모듈 각각 300 ng씩(그의 각각의 엔트리 벡터로부터 PCR에 의해 수득된 것)을 사용하여 3-단편 SLIC 반응을 수행하였다. 이를 통해 벡터 p15A-SceI E2-L4가 생성되었다. 5 ㎍의 p15A-SceI E2-L4를 SwaI로 절단하고, 퀴아젠 퀴아엑스II(Qiagen QiaexII)를 사용하여 겔 정제하였다. E3 및 E4 모듈은 그의 각각의 엔트리 벡터로부터 PCR에 의해 수득하였다. 각각의 선형화된 벡터(450 ng) 및 PCR 생성물(200 ng)을 T4 DNA 폴리머라제로 처리하고, 150-200 ng의 벡터 및 ~100 ng의 각 모듈 PCR을 사용하여 일반적인 방식으로 SLIC를 수행하였다. 양성 클론을 단리시킨 후, 5 ㎍의 새 벡터를 PacI로 절단하고, 겔 정제한 후, 새 SLIC 반응에서 E1 PCR 생성물(T4로 처리된 것, 100 ng)과 조합하였다. 이를 통해 게놈 조립은 완성되고, 플라스미드는 바이러스 재구성을 위한 형질감염시킬 준비가 되었다.

B. 변형된 아데노바이러스

*아데노바이러스는 유전자 전달 적용을 위해 빈번하게 사용된다. 예를 들어, 이는 트랜스진을 배양물 중의 세포로, 생체내에서 동물 조직으로, 또는 유전자 요법을 위해 생체내에서 인간 세포로 전달하는 데 사용된다. 이러한 방식으로 아데노바이러스를 사용하는 데 있어서 한가지 제한 인자는 유전자 발현이 일시적이라는 점이다. 아데노바이러스는 비통합성 바이러스이고, 따라서, 트랜스진 발현은 세포 분열시에 상실된다. 예컨대, 레트로바이러스 및 렌티바이러스처럼 통합성인 다른 바이러스 시스템을 유전자 전달이라는 같은 목적을 위해 사용하였다. 그러나, 이처럼 천연적으로 통합성인 바이러스는 소형인 바, 발현될 수 있는 트랜스진의 양에는 한계가 있고, 고역가로의 성장이 어려우며, 그로부터 다중 트랜스진을 발현시키기가 어렵고, 게놈 중의 무작위 위치에 통합시키는 것도 어렵다.

PhiC31 인터그라제가 ~280 bp attB 서열을 포함하는 외래의 환형 DNA를 위(pseudo) attP 부위로 알려져 있는 특이 위치에 숙주 세포 염색체 내로 통합시키는 것을 매개할 수 있다는 것이 입증되었다. 이러한 과정은 환형 플라스미드 DNA를 사용하여 입증되었지만, 예컨대, 아데노바이러스와 같은 바이러스의 사용으로는 입증된 바 없는데, 그 이유는 아데노바이러스 게놈이 선형이고, 염색체 절단을 일으키면서 통합을 수행하거나, 또는 통합을 수행하지 못하기 때문일 가능성이 높다. 이에, 본 발명자들은 형질도입시 게놈의 일부가 loxP 부위의 cre 매개 재조합을 통해 환형으로 되고, 이로써, PhiC31 인터그라제/attB를 통해 표적화된 통합이 이루어지도록 하는 방식으로 재조합 아데노바이러스 게놈이 생성되게 하는 시스템을 제공한다.

상기 기술을 위해, 아데노바이러스 게놈을 여러 방식으로 변형시켰다(도 31-33 참조). 먼저, E1 및 E3 영역을 결실시켜 다중 트랜스진이 발현되도록 하였다. E4 영역을 cre 리콤비나제 및 PhiC31 인터그라제를 발현하는 카세트로 치환하였다. tet 반응성 프로모터 또는 다른 유사한 조절가능 요소를 사용하여 상기 효소의 발현을 조절하였다. 2개의 loxP 부위를 게놈에 배치시켰는데, 하나는 트랜스진이 발현되는 E1 영역의 좌측 말단에 놓고, 나머지 하나는 섬유와 E4 영역 사이에 놓았다. 따라서, 이 두 loxP 부위 사이에 존재하는 것이 모두 세포 염색체 내로 삽입되는 것이었다. 마지막으로, PhiC31 attB 부위는, 비록 상기 짧은 서열의 특정 배치가 그가 loxP 부위 사이에 위치하는 한은 다른 위치에 존재할 수 있기는 하지만, E3 영역 내에 배치시켰다(본 실시예에서, 비록 cre 리콤비나제 및 PhiC31 인터그라제가 loxP 부위 및 트랜스진을 포함하는 동일의 아데노바이러스로부터 발현되기는 하지만, 본 발명자는 또한 별개의 바이러스로부터 상기 효소를 발현시킬 수 있었다).

아데노바이러스의 세포로의 형질도입시, cre 리콤비나제 및 PhiC31 인터그라제는 유도되고, cre는 아데노바이러스 게놈 중 loxP 부위의 재조합을 촉진시킨다. 이를 통해 loxP 부위 사이에 위치하는 DNA의 폐환화가 이루어진다. 이어서, 이로써, 인터그라제는 단편 중의 attB 부위를 사용하여 환형 단편을 세포 염색체로 재조합시킨다(도 33 참조). 최종 결과로 제한된 개수의 위치 중 한 위치에서 아데노바이러스 게놈의 선택된 일부의 숙주 세포 염색체 내로의 안정적인(비가역적인) 통합이 이루어진다. 트랜스진은 상기 통합으로부터 안정적으로 발현된다. 상기 공정으로 1) E1 영역이 결실되었고, 2) 바이러스 게놈의 말단이 결실되었기 때문에, 아데노바이러스 복제 또는 재활성화의 위험은 없었다. 상기 두 영역 모두가 바이러스 전사 및 복제에 필요한 것이었다.

현존 레트로바이러스 및 렌티바이러스 시스템에 비하여 본 시스템이 가지는 이점으로는 1) 무작위적이라기보다는 게놈 내의 제한된 개수의 위치에서 통합이 이루어진다는 점, 2) 트랜스진 발현을 위해 허용되는 크기가 증가되었다는 점, 3) 섬유 변형을 통해(도 39-42) 또는 다른 아데노바이러스 혈청형 및 종의 사용을 사용함으로써(도 45) 특이 세포 또는 조직에 아데노바이러스를 재표적화시킬 수 있는 능력이 있다는 점, 4) Ad셈블리 시스템을 사용한 조작이 용이하다는 점, 5) 바이러스를 고역가로 생산하기가 용이하다는 점, 및 6) 단일 벡터로부터 다중유전자를 발현시키기가 용이하다는 점을 포함한다.

본 시스템은 바이러스 매개 DNA 전달을 사용함으로써 ("점프-인(Jump-In)" 라인의 제품으로써 라이프 테크놀로지스(Life Technologies)에 의해 시판되는) 현 PhiC31 통합 기술을 발전시켰다. 현존 기술은 오직 플라스미드에만 기반을 둔 것이며, 따라서, 효율적으로 형질감염될 수 있거나, 전기천공될 수 있는 세포로만 제한된다. 또한, 특이 트랜스진 마우스가 생성되지 않는다면, 이는 사용될 수 없다. 생체내에서 트랜스진을 전달하는 데에는 통상 아데노바이러스가 사용되는 바, 따라서, 본 시스템을 통해 현존 기술의 수행 능력은 크게 확장되었다. 한가지 구현 방법은 변형된 아데노바이러스의 특이 조직으로의 적정가능하고 표적화된 전달을 통해 다중-유전자 발현 카세트를 사용하여 마우스 모델을 생성하는 것이 될 것이다. 또 다른 구현 방법은 표적화된 넉인(knock-in)을 위해 att 부위를 포함하는 마우스 계통에 대한 것이 될 것이다. 또 다른 구현 방법은 iPS에 대한 것이 될 것이다.

C. Ad셈블리를 사용한 완전하게 거의 야생형인 아데노바이러스 5형의 생성

Ad셈블리를 사용하여 하기 전략법을 이용함으로써 거의 야생형인 버전의 Ad5를 구성하였다. 게이트웨이 역선택 카세트 측면에 위치하는 야생형 코어 서열을 야생형 Ad5 E1 모듈, 야생형 Ad5 E3 모듈, 및 야생형 Ad5 E4 모듈과 혼합하였다(도 21). 완전하게 조립된 게놈을 포함하는 클론을 단리시키고, 293 세포로 형질감염시켰다. 7일 경과 후, 플라크가 시각적으로 관찰되었고, 바이러스를 수거하고, 추가의 293 세포 상에서 증폭시켰다. 성장 분석을 통해 거의 야생형인 바이러스(이는 실제로 야생형인 바이러스와 비교하였을 때, 3개의 attB 삽입을 포함한다)는 실제로 야생형인 바이러스처럼 단지 약간 감소된 역가로 성장한 것으로 밝혀졌다(도 28).

D. 복제 결함이 있고, GFP를 발현하며, 대체 혈청형으로부터 섬유 단백질을 포함하는 돌연변이체 Ad5의 생성

본 발명자들은 Ad셈블리를 사용하여 돌연변이체 Ad5를 생성하였다. E1A 및 E1B 영역을 결실시켜 상기의 새로운 벡터를 이용함으로써 임의의 바이러스가 복제 결함을 가지도록 Ad5 E1 모듈을 변경시켰다. E1A 및 E1B를 제거한 후, CMV IE 프로모터 및 GFP 유전자를 포함하는 포유동물 발현 카세트를 삽입하였다. Ad5 섬유 유전자가 Ad34로부터의 섬유 유전자로 치환될 수 있도록 Ad5 E3 모듈을 변경시켰다. 표준 Ad셈블리 반응에서 상기 돌연변이체 E1 및 E3-섬유 모듈을 게이트웨이 역선택 카세트 측면에 위치하는 야생형 Ad5 E4 모듈 및 야생형 Ad5 코어 모듈과 조합하였다(도 21). 완전하게 조립된 게놈인, 생성된 클론을 단리시키고, 293 세포에 형질감염시켰다. 7일 경과 후, 플라크가 시각적으로 관찰되었고, 바이러스를 수거하고, 추가의 293 세포 상에서 증폭시켰다. 상기 바이러스의 성장은 본 전략법이 1) 트랜스진 발현을 위해, 2) 형광성 유전자 발현을 위해, 3) 복제 결함이 있는 바이러스 구성을 위해, 4) 키메라 아데노바이러스 생성을 위해, 및 5) Ad5 배경에서의 대체 섬유 발현을 위해 사용될 수 있다는 것을 시사한다.

E. AdSlicR을 사용한 복제 수행 능력이 있는 Ad5의 생성

AdSlicR을 사용하여 아데노바이러스 유전자 모듈로부터 야생형 Ad5를 구성하였다. 야생형 E3 및 E4 모듈은 그의 아데노바이러스 유전자 모듈 벡터로부터 PCR에 의해 수득하였다. 이를 표준 SLIC 반응에서 SwaI로 절단된 야생형 Ad5 코어 모듈과 조합하였다(도 25). 성공적으로 E3 및 E4 모듈과 함께 코어 모듈을 포함하는 클론을 단리시키고, PacI로 절단하였다. 이어서, 이를 제2 SLIC 반응에서 아데노바이러스 유전자 모듈 벡터로부터 PCR에 의해 수득된 야생형 Ad5 E1 모듈과 조합하였다. 완전하게 조립된 게놈을 포함하는 클론을 단리시키고, 293 세포에 형질감염시켰다. 7일 경과 후, 플라크가 시각적으로 관찰되었다. 생성된 바이러스를 추가의 293 세포 상에서 증폭시켰다. 상기 바이러스에 관한 성장 분석을 통해 이는 야생형 Ad5와 동일한 역가로 성장하였다는 것이 밝혀졌다(도 28).

V. 표

하기 표 1-9에는 본원에서 제공하는 본 방법을 사용하여 제조되는 아데노바이러스 유전자 모듈 벡터, 목적 벡터 및 엔트리 벡터의 예가 개시되어 있다.

[표 1a]

[표 1b]

[표 1c]

[표 1d]

[표 1e]

[표 1f]

[표 2a]

[표 2b]

[표 2c]

[표 2d]

[표 3a]

[표 3b]

[표 4]

[표 5]

[표 6]

[표 7]

[표 8]

[표 9]

SEQUENCE LISTING <110> The Salk Institute for Biological Studies O'Shea, Clodagh Powers, Colin <120> Adenoviral Assembly Method <130> 92150-816208 <150> US 61/374,198 <151> 2010-08-16 <160> 143 <170> PatentIn version 3.5 <210> 1 <211> 1149 <212> PRT <213> Canine adenovirus 1 <400> 1 Met Ser Leu Val Gln Ser His Gly Thr Ser Gly Leu Phe Thr Glu Pro 1 5 10 15 Pro Asn Ser Ile Asn Gln Gln Glu Ser Ser Gly Pro Ser Leu Pro Ala 20 25 30 Gln Asp Ala Thr Gln Ala Ser Ala Ser Ser Ala Arg Ala Gly Ala Thr 35 40 45 Pro Ala Ile Asn Ser Thr Lys Arg Lys Tyr Arg Gly Ala Val Val Ala 50 55 60 Gln Arg Ala Thr Leu Ser Ile Ser Ala Ile Leu Asp Asn Gly Gln Cys 65 70 75 80 Val Gln Ile Lys Tyr His Ser Asn Leu Ala Ser Ala Leu Thr Asn Leu 85 90 95 Cys Asn Thr Asn Leu Tyr Asp Leu Pro Ala Cys Leu Asn Lys Pro Ile 100 105 110 Thr Val His Asn Leu Pro Thr Leu Ile Glu Glu Ala Ala Ala Ser Tyr 115 120 125 Ser Leu Ile Tyr Tyr Tyr Gln Arg Gly Thr Val Arg Lys Val Glu Phe 130 135 140 Arg Ala Glu Ile Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val Lys 145 150 155 160 His Gly Lys Val Phe Leu Ile Lys Asp Ile Ser Pro Met Gln Arg Cys 165 170 175 Glu Phe Cys Gly Ser Phe Phe Lys Val Thr His Thr Cys Thr Leu Arg 180 185 190 Arg Arg Asp Phe Tyr Phe His His Val Ala Ser His Ser Gly Asp Trp 195 200 205 Trp Glu Lys Ile Ser Phe Ser Pro Ile Gly Ala Pro Ala Asn Thr Glu 210 215 220 Arg Leu Phe Ile Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Lys 225 230 235 240 Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu Leu Gly 245 250 255 Asp Glu His Leu Val Asn Ala Ala Lys Asn Leu Ala Thr Thr Gln Asn 260 265 270 Trp Asp Thr Trp Asn Ser Asn Glu Gln Thr Ala Leu Tyr Tyr Cys Ile 275 280 285 Thr Pro Glu Lys Arg Ala Ile Gly Val Lys Phe Lys Thr Phe Arg Asp 290 295 300 Thr Leu Gln Gln His Phe Ala Asn Asn Leu Trp Ser His Val Leu Cys 305 310 315 320 Gln Asn Pro Lys Leu Met Glu Glu Ala Ala Ala Leu Gly Leu Glu Asn 325 330 335 Pro Glu Asp Ile Thr Ala Asn Gln Leu Lys Lys Phe Lys Leu Gln Gly 340 345 350 Thr Pro Arg Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Thr Gly 355 360 365 Phe Asp Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala Glu 370 375 380 Ile Pro Pro Val Phe Asp Ile Ser Arg Asn Phe Met Pro Arg Ala Gly 385 390 395 400 Arg Leu Leu Phe Asn Asp Ile Thr Tyr Ser Leu Pro Asn Pro Ser Tyr 405 410 415 Val Pro Ser Lys Asp Tyr Arg His Trp Glu Gln Gly Gln Val Leu Ala 420 425 430 Ser Asp Leu Lys Thr Gln Tyr Ile Lys Phe Met Val Arg Asp Thr Phe 435 440 445 Ser Leu Thr His Thr Ser Leu Lys Asn Ala Ala Lys Ala Tyr Ser Leu 450 455 460 Thr Val Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe Tyr 465 470 475 480 Met Leu Gly Ser Tyr Gln Gln Asp Ala Asp Gly Phe Pro Asp Leu Lys 485 490 495 Tyr Trp Lys Asp Gln Glu Glu Tyr Cys Phe Asn Lys Asp Leu Trp Lys 500 505 510 Lys Glu Lys Lys Gly Ala Tyr Asp Ile Ile Gln Gln Thr Leu Asp Tyr 515 520 525 Cys Ala Leu Asp Val Gln Val Thr Ala Gln Leu Val Asn Lys Leu Ile 530 535 540 Glu Ser Tyr Gln Ile Phe Ile Lys Asn Ser Val Asn Leu Pro Glu Thr 545 550 555 560 Tyr Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala 565 570 575 Ile Phe Lys Gln Ile Leu Tyr Arg Ala Glu Lys Pro Asn Ala Pro His 580 585 590 Leu Asn Thr Ile Ile Met Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val 595 600 605 Arg Leu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val 610 615 620 Leu Gln Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser 625 630 635 640 Ala Leu Thr His Pro Phe Pro Ala Gly Ser Pro Leu Asn Pro Tyr Glu 645 650 655 Arg Ala Val Ala Ile Lys Ala Tyr Glu His Lys Met Gln Glu His Lys 660 665 670 Thr Ile Ser Tyr Phe Asp Glu Asp Leu Leu Pro Gly Ile Phe Thr Ile 675 680 685 Asp Ala Asp Pro Pro Ala Glu Glu Phe Leu Asp Val Leu Pro Pro Phe 690 695 700 Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg 705 710 715 720 Gly Glu Val Thr Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly 725 730 735 Trp Lys Val Thr Leu Ile Pro Asp Thr Arg Thr Thr Val Phe Pro Glu 740 745 750 Trp Lys Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Asn Ala Lys 755 760 765 Glu Lys Ala Asp Lys Ser Lys Asn Gln Thr Met Arg Ser Ile Ala Lys 770 775 780 Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn 785 790 795 800 Lys Lys Thr Val Phe Ser Asp Gln Ile Glu Ser Asn Ile Ala Lys Glu 805 810 815 Ile Ala Ser Gly Ala Tyr Val Val Lys Ser Ser Ser Tyr Ile Glu Thr 820 825 830 Asp Asn Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro 835 840 845 Pro Val Asn Phe Asp Val His Arg Leu Ala Pro Pro Ser Tyr Ser Glu 850 855 860 Glu Tyr Pro Thr Glu Asn Pro His Ala Glu Gly Pro Phe Met Gln Asn 865 870 875 880 Phe Asn Met Thr Ser Tyr Arg Tyr Lys Pro Ile Met Phe Ile Asp Ala 885 890 895 Glu Asp Asp Asp Phe Cys Leu His Thr Leu Glu Lys Ser Thr Pro Leu 900 905 910 Ile Thr Asn Asn Arg Tyr Ala Ser Gln Ile Ala Ser Phe Val Leu Ala 915 920 925 Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln Phe Leu Tyr Glu Asn 930 935 940 Asp Ala Gly Ile Pro Leu Glu Lys Arg Ile Leu Lys Ser Val Tyr Gly 945 950 955 960 Asp Thr Asp Ser Leu Phe Thr Thr Met Glu Gly Tyr Arg Leu Met Glu 965 970 975 Glu Lys Gly Lys Arg Arg Leu Lys Lys Asn Gly Gly Asn Leu Val Phe 980 985 990 Asp Pro Asn Asn Pro Glu Leu Thr Trp Leu Val Glu Cys Glu Thr Lys 995 1000 1005 Cys Glu Lys Cys Gly Ala Asp Ala Tyr Ser Ser Glu Ser Val Tyr 1010 1015 1020 Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys Pro Glu 1025 1030 1035 Cys Gln Tyr Val Gly Lys Gly Lys Leu Arg Ala Lys Gly His Ala 1040 1045 1050 Thr Ser Thr Leu Ser Tyr Asp Val Leu Lys Ala Cys Tyr Tyr Ala 1055 1060 1065 Asp Leu Gln Gln Gly Ser Asp Ile Phe Lys Thr Ser Arg Met Ser 1070 1075 1080 Leu Arg Arg Thr Leu Thr Ser Val Gln Thr His Val Gln Pro Phe 1085 1090 1095 Thr Val Thr Glu Thr Thr Leu Thr Arg Lys Leu Arg Pro Trp Lys 1100 1105 1110 Asp Lys Thr Leu His Ala Leu Asp Met Asn Arg Leu Ile Pro Tyr 1115 1120 1125 Ser Arg Lys Tyr Pro Asn Pro Arg Asn Asn Glu Thr Thr Trp Met 1130 1135 1140 Glu Leu Gln Trp Met Thr 1145 <210> 2 <211> 1150 <212> PRT <213> Canine adenovirus 2 <400> 2 Met Ser Leu Val Gln Gly His Gly Thr Ser Gly Leu Phe Thr Glu Pro 1 5 10 15 Pro Asn Pro Ile Asn Gln Gln Glu Ser Ser Gly Pro Ser Leu Pro Ala 20 25 30 Gln Asp Ala Ala Gln Ala Phe Ala Ser Ser Pro Arg Ala Gly Ala Thr 35 40 45 Ser Thr Ile Val Asn Pro Pro Lys Arg Lys Tyr Lys Gly Ala Val Val 50 55 60 Val Gln Arg Ala Thr Leu Ser Ile Ser Ala Val Leu Asp Asn Gly Gln 65 70 75 80 Cys Val Glu Ile Lys Tyr His Ser Asn Leu Ala Ser Ala Leu Thr Asn 85 90 95 Leu Cys Asn Thr Asn Leu Tyr Asp Leu Pro Ala Cys Leu Asn Arg Pro 100 105 110 Ile Thr Ala His Asn Leu Pro Ala Leu Ile Glu Glu Ala Ala Ala Pro 115 120 125 Tyr Ser Leu Ile Cys Tyr Tyr Gln Arg Gly Thr Val Arg Arg Val Glu 130 135 140 Phe Gln Ala Glu Val Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val 145 150 155 160 Lys Gln Gly Lys Val Phe Leu Ile Lys Asp Ile Ser Gln Met Gln Lys 165 170 175 Cys Glu Phe Cys Gly Ser Phe Phe Lys Val Thr His Thr Cys Ala Leu 180 185 190 Arg Arg Arg Asp Phe Tyr Phe His His Val Ala Ala His Ser Ala Asp 195 200 205 Trp Trp Glu Lys Ile Ser Phe Thr Pro Ile Gly Ala Pro Pro Asn Thr 210 215 220 Glu Arg Leu Phe Ile Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly 225 230 235 240 Lys Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu Leu 245 250 255 Gly Asp Asp His Leu Val Asn Val Ala Lys Thr Leu Ala Thr Glu Gln 260 265 270 Asn Trp Glu Ile Trp Asn Gly Lys Glu Gln Asp Thr Leu Tyr Tyr Cys 275 280 285 Ile Thr Pro Glu Lys Arg Ala Ile Gly Val Lys Phe Lys Lys Phe Arg 290 295 300 Asp Thr Leu Gln Gln His Ile Ala Ala Ser Leu Trp Ser His Val Ile 305 310 315 320 Cys Gln Asn Pro Gln Leu Gln Glu Lys Ala Thr Thr Leu Gly Leu Glu 325 330 335 Ser Pro Glu Glu Leu Thr Pro Asp Gln Leu Lys Lys Phe Lys Leu Lys 340 345 350 Gly Asn Pro Arg Phe Ile Glu Val Tyr Ala Val Gly His Asn Ile Thr 355 360 365 Gly Phe Asp Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala 370 375 380 Glu Ile Pro Pro Val Phe Glu Ile Cys Arg Asn Phe Met Pro Arg Ala 385 390 395 400 Gly Arg Leu Leu Phe Asn Asp Ile Thr Tyr Ser Leu Pro Asn Pro Ser 405 410 415 Tyr Val Pro Ala Lys Ser Tyr Glu His Trp Glu Gln Gly Gln Val Leu 420 425 430 Ala Ser Asp Leu Lys Ser Gln Tyr Ile Lys Phe Met Val Arg Asp Thr 435 440 445 Phe Ser Leu Thr His Thr Ser Leu Lys Asn Ala Ala Lys Ala Tyr Ser 450 455 460 Leu Thr Val Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe 465 470 475 480 Tyr Met Leu Gly Ser Tyr Gln Gln Asp Ala Asp Gly Phe Pro Asp Leu 485 490 495 Lys Tyr Trp Lys Asp Gln Glu Glu Tyr Ser Phe Asn Lys Asp Leu Trp 500 505 510 Ile Lys Glu Lys Lys Gly Ala Tyr Asp Ile Ile Gln Gln Thr Leu Asp 515 520 525 Tyr Cys Ala Leu Asp Val Gln Val Thr Ala Gln Leu Val Asn Lys Leu 530 535 540 Ile Glu Ser Tyr Gln Ile Phe Ile Lys Asn Ser Val Asn Leu Pro Glu 545 550 555 560 Thr Ser Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His 565 570 575 Ala Ile Phe Lys Gln Ile Leu Tyr Lys Ala Glu Lys Pro Asn Thr His 580 585 590 His Leu Ser Thr Ile Leu Met Ala Pro Ser Asn Glu Met Tyr Glu Tyr 595 600 605 Val Arg Leu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly 610 615 620 Val Leu Gln Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala 625 630 635 640 Ser Ala Leu Thr His Pro Phe Pro Ala Gly Ser Pro Leu Asn Pro Tyr 645 650 655 Glu Arg Ala Leu Ala Ile Lys Ala Tyr Glu Gln Lys Met Leu Asn His 660 665 670 Lys Thr Ile Ser Tyr Phe Asp Lys Asp Leu Leu Pro Gly Ile Phe Thr 675 680 685 Ile Asp Ala Asp Pro Pro Ala Glu Glu Phe Leu Asp Val Leu Pro Pro 690 695 700 Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu 705 710 715 720 Arg Gly Glu Ile Ala Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg 725 730 735 Gly Trp Lys Val Thr Leu Ile Pro Asp Thr Arg Thr Thr Val Phe Pro 740 745 750 Glu Trp Lys Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Ser Ala 755 760 765 Lys Glu Glu Ala Asp Lys Ser Lys Asn Gln Thr Met Arg Ser Ile Ala 770 775 780 Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp 785 790 795 800 Asn Lys Lys Thr Val Phe Ser Asp Gln Ile Glu Ser Asn Ile Ala Lys 805 810 815 Glu Ile Ala Ser Gly Ala Tyr Val Val Lys Ser Ser Ser Tyr Ile Glu 820 825 830 Thr Asp Asn Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr 835 840 845 Pro Pro Val Asn Ser Asp Val Arg Gln Leu Ala Pro Pro Ser Cys Ser 850 855 860 Glu Glu Asp Pro Thr Lys Asp Pro Leu Ala Glu Ala Pro Phe Met His 865 870 875 880 Asn Phe Ser Met Thr Ser Tyr His Tyr Lys Pro Ile Met Phe Ile Asp 885 890 895 Ala Glu Asp Asp Asp Phe Cys Leu His Thr Leu Glu Lys Ser Thr Pro 900 905 910 Leu Ile Ala Asn Asn Arg Tyr Pro Ser Gln Ile Ala Ser Phe Val Leu 915 920 925 Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln Phe Leu Tyr Glu 930 935 940 Asn Asp Ala Gly Thr Pro Leu Glu Asn Arg Val Leu Lys Ser Val Tyr 945 950 955 960 Gly Asp Thr Asp Ser Leu Phe Thr Thr Met Glu Gly Tyr Lys Leu Met 965 970 975 Glu Glu Lys Gly Lys Lys Arg Leu Lys Lys Asn Gly Gly Lys Leu Val 980 985 990 Phe Asp Pro Ser Asn Pro Glu Leu Thr Trp Leu Val Glu Cys Glu Thr 995 1000 1005 Gln Cys Glu Lys Cys Gly Ser Asp Ala Tyr Ser Ser Glu Ser Val 1010 1015 1020 Tyr Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys Pro 1025 1030 1035 Lys Cys His His Val Gly Lys Gly Lys Leu Arg Ala Lys Gly His 1040 1045 1050 Ala Thr Ser Thr Leu Ser Tyr Asp Val Leu Lys Ala Cys Tyr Tyr 1055 1060 1065 Ala Asp Met Gln Gln Gly Ser Asp Val Phe Lys Thr Ser Arg Met 1070 1075 1080 Ser Leu Arg Arg Thr Leu Thr Ser Val Gln Ala His Val Gln Pro 1085 1090 1095 Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Lys Leu Arg Pro Trp 1100 1105 1110 Lys Asp Lys Thr Leu His Ala Leu Asp Met His Arg Leu Ile Pro 1115 1120 1125 Tyr Ser Arg Lys His Pro Asn Pro Arg Asn Thr Glu Thr Thr Trp 1130 1135 1140 Met Glu Leu Gln Trp Met Thr 1145 1150 <210> 3 <211> 1135 <212> PRT <213> Bat adenovirus PPV1 <400> 3 Val Gln Gly Asp Arg Thr Arg Gly Ile Leu Pro Lys Gln Thr Asp Ser 1 5 10 15 Asn Tyr Gln Pro Lys Gly Ser Ser Ala Ser Leu Ser Ala Glu Ile Gln 20 25 30 Ser Gln Thr Thr Pro Gly Thr Pro Arg Pro Ser Thr Ala Ser Ser Leu 35 40 45 Lys Thr Pro Arg Arg Lys Tyr Lys Gly Ala Val Val Ala Gln Arg Ala 50 55 60 Thr Leu Ser Ile Ser Ala Met Leu Asp Asp Gly Gln Pro Ala Glu Ile 65 70 75 80 Lys Phe His Ser Asn Leu Leu Thr Ala Leu Thr Ala Leu Cys Asn Thr 85 90 95 Asn Leu His Asp Leu Pro Glu Cys Phe Leu Ala Pro Ile Thr Ala Pro 100 105 110 Asn Leu Pro Ala Leu Ile Glu Gln Ala Ala Ala Pro Tyr Ser Leu Ile 115 120 125 Cys Tyr Tyr Asn Arg Gly Ser Val Arg Arg Val Gln Phe Gln Ala Glu 130 135 140 Ser Pro Leu Leu Ser Phe Pro Leu Lys Phe Leu Val Lys His Asn Lys 145 150 155 160 Val Phe Leu Ile Lys Asp Ile Ser Pro Val Asn Lys Cys Glu Phe Cys 165 170 175 Gly Ser Phe Phe Lys Val Thr His Thr Cys Ser Leu Arg Arg Arg Asp 180 185 190 Phe Tyr Tyr His His Val Ala Ala His Ser Ser Asp Trp Trp Glu Lys 195 200 205 Ile Ala Phe Ala Pro Ile Gly Ser Pro Ala Glu Thr Glu Arg Leu Phe 210 215 220 Ile Val Tyr Asp Ile Glu Thr Tyr Thr Trp His Gly Lys Phe Gly Lys 225 230 235 240 Gln Leu Val Pro Phe Met Leu Val Phe Gln Leu His Gly Asp Ala His 245 250 255 Leu Val Ala Ala Ala Thr Ala Leu Ala Arg Glu Leu Gly Trp Asp Arg 260 265 270 Trp Gln Asp Lys Glu Asp Val Phe Cys Ile Val Thr Pro Glu Lys Arg 275 280 285 Val Ile Gly Ile Lys Phe Lys Gln Phe Arg Asp Arg Leu Gln Gln Cys 290 295 300 Leu Ala Asn Ser Leu Trp Ser His Phe Leu Val Ala Asn Pro Gln Ile 305 310 315 320 Gln Glu Glu Ala Thr Asn Arg Gly Leu Ala Cys Pro Glu Asp Leu Phe 325 330 335 Pro Glu Asp Leu Arg Lys Ile Lys Val Lys Gly Val Pro Arg Phe Ile 340 345 350 Glu Val Tyr Ala Val Gly His Asn Ile Thr Gly Phe Asp Glu Ile Leu 355 360 365 Leu Ala Ala Gln Val Val Ser Thr Lys Ala Glu Ile Pro Ser Val Phe 370 375 380 Glu Ile Ser Arg Asn Phe Met Pro Arg Ala Gly Arg Leu Leu Phe Asn 385 390 395 400 Asp Val Thr Tyr Ser Leu Pro Asn Pro Ala Trp Val Pro Thr Lys Thr 405 410 415 Phe Glu His Trp Glu Ala Gly Gln Leu Ser Ala Cys Asp Leu Lys Asn 420 425 430 Gln Phe Leu Lys Phe Met Val Arg Asp Thr Phe Thr Leu Thr His Thr 435 440 445 Ser Leu Arg Asn Ala Ala Lys Ala Tyr Ser Leu Pro Val Ala Lys Gly 450 455 460 Cys Cys Pro Tyr Gln Ala Val Asn Asp Phe Tyr Met Leu Gly Thr Tyr 465 470 475 480 Gln Gln Asp Glu Gln Gly Phe Pro Ala Val Glu Tyr Trp Lys Asp Arg 485 490 495 Glu Glu Tyr Leu Leu Asn Lys Ala Leu Trp Leu Asp Lys Lys Thr Gly 500 505 510 Ala Tyr Asp Ile Val Gln Gln Thr Leu Asp Tyr Cys Ala Leu Asp Val 515 520 525 Gln Val Thr Ala Gln Leu Val Gln Lys Leu Ile Ala Ser Tyr Gln Glu 530 535 540 Phe Ile Ala Thr Ser Val Asn Leu Pro Ala Ala Ser Phe Asn Val Phe 545 550 555 560 Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Lys Gln Ile 565 570 575 Leu Tyr Arg Ala Glu Gln Pro Gly Gln Gly His Phe Asn Thr Ile Leu 580 585 590 Leu Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val Arg Ala Ser Ile Arg 595 600 605 Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Ala Glu Pro Val 610 615 620 Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro 625 630 635 640 Phe Pro Ala Gly Ala Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Met 645 650 655 Arg Ala Tyr Glu Leu Lys Met Gln Gln Cys Pro Gln Ile Ser Tyr Phe 660 665 670 Asp Ala Glu Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp Pro Pro 675 680 685 Glu Asp Ser His Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly 690 695 700 Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Ile Ala Thr 705 710 715 720 Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys Val Thr Leu 725 730 735 Val Pro Asp Ala Arg Ala Thr Val Phe Pro Glu Trp Lys Cys Ile Ala 740 745 750 Arg Glu Tyr Val Gln Leu Asn Ile Asn Ala Lys Glu Lys Ala Asp Lys 755 760 765 Asp Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala 770 775 780 Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Thr Val Phe 785 790 795 800 Ser Asp Gln Ile Glu His Asn Leu Ala Lys Glu Ile Ala Ala Gly Glu 805 810 815 Phe Val Val Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn Leu Cys Ala 820 825 830 Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro Pro Ala Asp Thr Pro 835 840 845 Ser Ser Glu Val Asp Ala Ser Pro Leu Ser Glu Asp Pro Glu Glu Thr 850 855 860 Pro Phe Ile Gly Asn Asp Arg Met Thr Ser Tyr Thr Tyr Lys Pro Ile 865 870 875 880 Thr Phe Leu Asp Ala Glu Asp Asp Ser Phe Cys Leu Gln Thr Leu Glu 885 890 895 Arg Ala Ser Pro Leu Ile Ala Asn Asn Arg Tyr Pro Ser Gln Ile Ala 900 905 910 Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Gln 915 920 925 Phe Leu Tyr Ala Asp Asp Val Gly Ile Pro Leu Glu Asp Arg Gln Leu 930 935 940 Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Thr Thr Leu Glu Gly 945 950 955 960 Tyr Lys Leu Met Glu Thr Lys Gly Lys His Arg Leu Lys Lys Asn Gly 965 970 975 Gly Lys Leu Val Phe Asp Pro Ser Asn Pro Glu Leu Thr Trp Leu Val 980 985 990 Glu Cys Glu Thr Gln Cys Glu Lys Cys Gly Ser Asp Ala Tyr Ser Ser 995 1000 1005 Glu Ser Val Tyr Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr 1010 1015 1020 Thr Cys Val Ser Cys Gly His Val Gly Lys Gly Lys Leu Arg Ala 1025 1030 1035 Lys Gly His Ala Thr Ser Ser Leu Ser Tyr Asp Val Leu Lys Ala 1040 1045 1050 Cys Tyr Leu Ala Asp Met Gln His Gly Ser Asp Val Phe His Thr 1055 1060 1065 Ser Arg Met Ser Leu Arg Arg Thr Leu Thr Ser Val Gln Ser His 1070 1075 1080 Val Gln Pro Phe Thr Val Thr Glu Thr Thr Leu Lys Arg Arg Leu 1085 1090 1095 Arg Pro Trp Lys Asp Lys Thr Leu His Pro Leu Asp Ala Asn Arg 1100 1105 1110 Leu Val Pro Tyr Ser Arg Arg Phe Pro Asn Pro Arg Asn Thr Glu 1115 1120 1125 Thr Thr Trp Met Glu Trp Gln 1130 1135 <210> 4 <211> 1142 <212> PRT <213> Bat adenovirus TJM <400> 4 Met Ala Leu Val Gln Asn Asp Gly Ala Arg Arg Leu Phe Pro Glu Gln 1 5 10 15 Pro Asn Ser Asp His Gln Pro Pro Gly His Ser Pro Gly Glu Pro Ala 20 25 30 Gln Ile Pro Ala Pro Ser Pro Ala Gly Ala Pro Leu Pro Gly Ala Ala 35 40 45 Ala Pro Val Lys Pro Gln Arg Arg Gln Tyr Lys Gly Ala Val Val Thr 50 55 60 Gln Arg Ala Thr Leu Ser Val Ser Ala Val Leu Asp Asp Gly Gln Phe 65 70 75 80 Val Glu Ile Lys Tyr His Ala Asp Trp Lys Ala Ala Leu Ala Ser Leu 85 90 95 Cys His Ala Asn Leu Cys Glu Val Pro Ala Cys Phe Glu Asn Pro Leu 100 105 110 Thr Pro Tyr Ser Leu Leu Thr Leu Leu Glu Gln Ala Ala Ala Ala His 115 120 125 Ser Leu Ile Cys Tyr Tyr Gln Arg Gly Lys Val Arg Arg Val Gln Met 130 135 140 Gln Ala Ala Gln Pro Leu Leu His Phe Pro Leu Gln Phe Leu Val Lys 145 150 155 160 Gln Ala Lys Phe Thr Ser Leu Lys Thr Leu Pro Pro Pro Thr Ser Ala 165 170 175 Ser Ser Val Val Leu Ser Thr Arg Ser Pro Thr Pro Ala Pro Ser Gly 180 185 190 Ala Glu Thr Phe Thr Ser Thr Thr Leu Pro Pro Thr Pro Pro Thr Gly 195 200 205 Gly Lys Arg Gln Pro Ser Pro Leu Trp Asp Leu Pro Arg Lys Pro Lys 210 215 220 Gly Cys Leu Leu Ser Met Thr Ser Arg Pro Thr Pro Gly Thr Gly Ala 225 230 235 240 Leu Ala Ser Asn Trp Tyr Pro Ser Cys Gln Ser Ser Ser Trp Trp Ala 245 250 255 Arg Pro Pro Trp Trp Pro Arg Pro Gly Ser Trp Pro Arg Pro Arg Asp 260 265 270 Gly Thr Pro Gly Thr Leu Arg Glu Met Ser Phe Thr Ala Ser Pro Leu 275 280 285 Arg Lys Lys Pro Ser Val Ser Ser Leu Arg Ser Ser Gly Thr Arg Cys 290 295 300 Ser Ser Cys Trp Pro Pro Ser Ser Gly Ser His Phe Leu Ser Gln Asn 305 310 315 320 Pro Asp Leu Glu Ala Lys Thr Arg Glu Leu Gly Leu Pro Asn Ser Glu 325 330 335 Asp Ile Ser Tyr Ala Ala Leu Lys Lys Leu Lys Leu Gln Gly Ala Pro 340 345 350 Arg Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Thr Gly Phe Asp 355 360 365 Glu Ile Leu Leu Ala Ala Gln Val Val Ser Thr Arg Ala Glu Ile Pro 370 375 380 Pro Ala Phe Gln Ile Ser Arg Asn Phe Met Pro Arg Ala Gly Arg Leu 385 390 395 400 Leu Phe Asn Asp Val Thr Tyr Ala Leu Pro Asn Pro Ala Tyr Phe Pro 405 410 415 Arg Lys Asp Tyr Thr Asp Trp Glu Lys Gly Gln Leu Leu Ala Cys Asp 420 425 430 Leu Arg Asn Gln Phe Ile Lys Phe Met Val Arg Asp Thr Phe Thr Leu 435 440 445 Thr His Thr Ser Leu Arg Asn Ala Ala Lys Ala Tyr Asn Leu Pro Val 450 455 460 Ser Lys Gly Cys Cys Pro Tyr Gln Ala Val Asn Glu Phe Tyr Met Leu 465 470 475 480 Gly Thr Tyr Arg Arg Asp Ala Asp Gly Phe Pro Ala Glu Asp Tyr Trp 485 490 495 Lys Asp Ala Glu Glu Tyr Arg Phe Asn Lys Gln Leu Trp Arg Glu Glu 500 505 510 Lys Lys Asp Ala Tyr Asp Ile Ile Gln Ser Thr Leu Asp Tyr Cys Ala 515 520 525 Gln Asp Val Lys Val Thr Thr Gln Leu Val Leu Lys Leu Thr Glu Ala 530 535 540 Tyr Gln Ala Phe Val Ala Glu Ser Val Asn Leu Pro Glu Ala Ser Phe 545 550 555 560 Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Leu Phe 565 570 575 Lys Gln Ile Leu Phe Arg Ala Glu Lys Pro Asn Gln Ser His Leu Gly 580 585 590 Thr Thr Leu Leu Ala Pro Ser Asn Glu Met Tyr Glu Tyr Val Arg Ala 595 600 605 Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Phe Ile Gly Leu Leu Asp 610 615 620 Glu Pro Val Phe Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu 625 630 635 640 Thr His Pro Phe Pro Ala Gly Pro Pro Leu Asn Pro Phe Glu Arg Ala 645 650 655 Leu Ala Val Arg Arg Tyr Glu Leu Lys Met Gln Thr Glu Ala Gln Ile 660 665 670 Ser Tyr Phe Asp Pro Glu Leu Leu Pro Ala Ile Leu Thr Ile Asp Ala 675 680 685 Asp Pro Pro Ala Asp Glu Phe Leu Asp Val Leu Pro Pro Phe Cys Ser 690 695 700 Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu 705 710 715 720 Val Ala Thr Ser Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys 725 730 735 Val Arg Phe Val Pro Asp Ala Arg Ala Thr Val Phe Pro Glu Trp Lys 740 745 750 Cys Leu Ala Arg Glu Tyr Val Gln Leu Asn Ile Gln Ala Lys Glu Gln 755 760 765 Ala Asp Lys Asn Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu 770 775 780 Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys 785 790 795 800 Thr Val Phe Ser Asp Gln Ile Asp Ala Glu Thr Ala His Asp Ile Ser 805 810 815 Thr Gly Ala Phe Val Val Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn 820 825 830 Leu Cys Ala Glu Ile Met Pro Glu Phe Val Val Ala Tyr Pro Pro Asp 835 840 845 Pro Ser Val Ala Leu Thr His Thr Ala Val Ala Asn Asp Gly Asp Pro 850 855 860 His Pro Glu Thr Pro Phe Met Ser Pro Thr Ser Val Thr Ser Tyr Thr 865 870 875 880 Tyr Lys Pro Ile Thr Phe Leu Asp Ala Glu Asp Asp Asp Phe Cys Leu 885 890 895 His Thr Leu Glu Lys Ser Thr Pro Leu Ile Ala Asn Asn Arg Tyr Pro 900 905 910 Ser Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser 915 920 925 Glu Trp Ala Gln Phe Leu Tyr Ala Asp Asp Ala Gly Ile Pro Leu Glu 930 935 940 Lys Arg Asn Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Thr 945 950 955 960 Thr Arg Glu Gly Tyr Arg Leu Met Glu Glu Lys Gly Lys Lys Arg Leu 965 970 975 Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Asp His Pro Glu Leu 980 985 990 Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys Gly Gly Asp 995 1000 1005 Ala Tyr Ser Thr Glu Ser Val Tyr Leu Ala Pro Lys Leu Tyr Ala 1010 1015 1020 Leu Lys Asn Thr Val Cys Thr Arg Cys Gly His Val Gly Lys Gly 1025 1030 1035 Lys Leu Arg Ala Lys Gly His Ala Thr Ser Glu Leu Ser Tyr Asp 1040 1045 1050 Thr Leu Lys Ala Cys Tyr Leu Ala Asp Leu Gln Gln Gly Ser Asp 1055 1060 1065 Val Phe Gln Thr Ser Arg Thr Ser Leu Arg Arg Thr Leu Ala Ser 1070 1075 1080 Val Gln Ala His Val Gln Pro Phe Thr Val Thr Glu Thr Thr Leu 1085 1090 1095 Thr Arg Lys Leu Arg Pro Trp Lys Asp Lys Thr Leu His Glu Val 1100 1105 1110 Asp Ser His Arg Leu Ile Pro Tyr Ser Arg Arg Phe Pro Asn Pro 1115 1120 1125 Arg Asn Thr Glu Thr Thr Trp Met Glu Leu Pro Trp Thr Ser 1130 1135 1140 <210> 5 <211> 1112 <212> PRT <213> Turkey adenovirus 3 <400> 5 Met Ser Lys Tyr Ile Tyr Thr Thr Gln Asn Glu Ile Pro Tyr Arg Leu 1 5 10 15 Gln Ile Cys Lys Lys Asp Ile Lys Ala Thr Ile Ile Glu Ile Ala Trp 20 25 30 Thr Tyr Asn Leu Phe Asn Cys Lys Lys Leu Ala Lys Lys Val Lys Asp 35 40 45 Ala Gln Ser Tyr Ile Leu Ile Cys Ser Lys Tyr Lys Pro Thr Asn Ser 50 55 60 Asp Ile Glu Asn Val Lys Asn Leu Pro Val Lys Ser Ile Thr Ile Trp 65 70 75 80 Lys Lys Leu Thr Gly Cys Val Met Ile Gln Asn Glu Phe Lys Thr Ser 85 90 95 His Glu Tyr Ile Glu Leu Asp Phe Ile Tyr Asp Lys Ser Lys Leu Cys 100 105 110 Trp Ile Lys Ser Trp Thr Gln Gln Gln Lys Cys Ser Ser Cys Gly Arg 115 120 125 Ile Tyr Ser Ala Ile His Thr Cys Asn Asp Leu Arg Ser Thr Tyr Tyr 130 135 140 Tyr Asn Ser Val Asp Asn Asp Thr Arg Lys Phe Trp Glu Thr Ile Pro 145 150 155 160 Phe Gln Pro Ile Gly Glu Asn Glu Asn Thr Lys Lys Leu Phe Leu Ile 165 170 175 Tyr Asp Ile Glu Thr Phe Thr Leu Ala Glu Thr Ser Gly Val Leu Leu 180 185 190 Asn Pro Leu Leu Leu Cys Phe Ser Ile Phe Gly Asp Asp Cys Leu Ile 195 200 205 Asn Ile Cys Lys Thr Glu Ile Ala Lys Ile Lys Ser Ile Gln Thr Lys 210 215 220 Asn Ser Thr Tyr Phe Trp Phe Ser Lys Val Lys Asn Phe Ile Ser Thr 225 230 235 240 Glu Phe Arg Lys Leu Arg Asn Asn Ile Leu Phe Ala Leu Thr Asp Tyr 245 250 255 Phe Thr Lys Leu Ile Leu Thr Pro Glu Asn Arg Glu Ile Leu Glu Asp 260 265 270 Phe Ala Gln Thr Gln Asn Leu Glu Ser Ile Thr Asn Ile Asn Leu Ser 275 280 285 Glu His Thr Asn Leu Ile Met Ser Leu Lys Val Lys Pro Ile Phe Ile 290 295 300 Glu Phe Tyr Ile Ile Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu 305 310 315 320 Leu Ala Thr Gln Ile Leu Gln Asp Glu Asn Leu Asp Ile Thr Pro Leu 325 330 335 Phe Thr Val Glu Arg Asn Phe Met Pro Arg Gln Gly Arg Ile Leu Phe 340 345 350 Asn Asp Ile Thr Ile Lys Phe Pro Asn Pro Asp Tyr Tyr Val Ala Lys 355 360 365 Glu Glu Lys Lys Asn Asn Lys Ser Glu Ile Leu Ser Gln Ile Lys Glu 370 375 380 Gly Ile Pro His Pro Glu Ser Ile Lys Asn Leu Tyr Ile Lys Ser Met 385 390 395 400 Val Arg Asp Thr Phe Gln Ile Thr His Thr Ser Leu Lys Glu Ala Ala 405 410 415 Lys Ala Tyr Asn Leu Lys Ile His Lys Gly Cys Cys Pro Phe Lys Ala 420 425 430 Ile Asn Glu Tyr Met Ser Thr Asn Ser Leu Ser Thr Asp Ser Asp Ser 435 440 445 Phe Pro Ser Glu Lys Tyr Trp Ser Ser Lys Glu Glu Tyr Asn Glu Gln 450 455 460 Lys Glu Ile Trp Leu Glu Lys Lys Glu Val Lys Tyr Asp Ile Val Lys 465 470 475 480 Glu Leu Ile Asp Tyr Cys Ile Lys Asp Val Lys Ile Thr Glu Glu Leu 485 490 495 Thr Lys Thr Leu Leu Asn Thr Phe Asp Thr Phe Ile Lys Glu Glu Leu 500 505 510 Asn Leu Lys Cys Asn Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser Ser 515 520 525 Asn Ser His Ala Ile Phe Arg Gln Leu His Phe Lys Gln Asn Gly Thr 530 535 540 Lys Ala Ser Thr Leu Pro Asp Ile Val Ala Pro Ser Asp Glu Met Tyr 545 550 555 560 Ser Phe Ile Arg Gln Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr His 565 570 575 Leu Gly Ile Phe Lys Glu Lys Ile Phe Val Tyr Asp Ile Cys Gly Met 580 585 590 Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Phe Pro Ile Gly 595 600 605 Glu Lys Glu Arg Asn Asn Glu Ile Thr Lys Leu Asn Glu Lys Leu Lys 610 615 620 Lys Thr Lys Thr Lys Leu Ser Tyr Phe Thr Asp Ile Lys Pro Met Val 625 630 635 640 Val Met Ile Asp Ala Ile Pro Pro Pro Pro Glu His Leu Asp Pro Leu 645 650 655 Pro Pro Leu Cys Ser Arg Gln Ser Gly Lys Leu Cys Trp Thr Asn Glu 660 665 670 Ile Leu Lys Asn Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His 675 680 685 Asn Arg Gly Trp Lys Val Asn Ile Ile Pro His Lys Leu Asn Thr Val 690 695 700 Phe Pro Thr Trp Asn Thr Cys Cys Leu Glu Tyr Val Thr Lys Asn Ile 705 710 715 720 Leu Ala Lys Glu Lys Ala Thr Val Glu Lys Asn Pro Val Lys Arg Ala 725 730 735 Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg 740 745 750 Glu Ser Asn Asp Ile Thr Ile Phe Glu Asn His Ile Gln Glu Asn Pro 755 760 765 Lys Ile Arg Asn Gln Leu Leu Asn Lys Gln Leu Thr Ile Asp Ser Ile 770 775 780 Thr Thr Leu Pro Thr Tyr Asn Leu Pro Tyr Val Ser Ile Glu Asn Leu 785 790 795 800 Thr Phe Thr Leu Lys Asn Arg Thr Asp Ser Ala Glu Arg Asn Leu Glu 805 810 815 Leu Asp Asp Glu Leu Thr Ser Pro Phe Asn Ser Leu Glu Phe Met Asp 820 825 830 Glu Ser Pro Ala Ser Gln Thr Ser Thr Ser Thr Ala His Val Gly Thr 835 840 845 Tyr Lys Pro Phe Asn Ile Leu Asp Val Thr Ser Glu Asn Leu Thr Ile 850 855 860 Tyr Met Leu Lys Ser Thr Asn Leu His Pro Thr Asn Lys Arg Tyr Pro 865 870 875 880 Thr Gln Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser 885 890 895 Glu Trp Arg Glu Ile Leu Tyr Ser Asp Glu Asp Ser Ile Pro Val Gln 900 905 910 Phe Lys Thr Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu 915 920 925 Thr Glu Lys Gly His Gln Asn Met Leu Lys Tyr Gly Gln His Arg Ile 930 935 940 Lys Asn Lys Asn Ser Gln Leu Thr Phe Asp Pro Lys Lys Pro Ser Ile 945 950 955 960 Val Trp Ala Val Glu Cys Glu Thr Trp Cys Asn Leu Cys Asn Ser Pro 965 970 975 Ala Tyr Ser Ser Lys Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu 980 985 990 Lys Glu Ile Thr Cys Thr Thr Cys Lys Asn Ser Lys Thr Gly Lys Leu 995 1000 1005 Arg Ala Lys Gly His Cys Thr Ala Asp Ile Thr Phe Glu Ile Leu 1010 1015 1020 Glu Glu Cys Phe Asn Tyr His Thr Ser Glu Leu Lys Ser Gly Glu 1025 1030 1035 Ile Phe Gln Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Cys Lys 1040 1045 1050 Ser Tyr Gly Lys Phe Ser Pro Phe Ser Val His Glu Ile Gln Leu 1055 1060 1065 Ile Arg Glu Leu Arg Pro Trp Asn Asp Pro Thr Leu Tyr Phe Leu 1070 1075 1080 Lys Thr Asn Thr Leu Ile Pro Tyr Asp Leu Tyr His Pro Asn Pro 1085 1090 1095 Arg Ile Thr Asn Pro Ile Leu Leu Gln Glu Phe Glu Asp Glu 1100 1105 1110 <210> 6 <211> 1112 <212> PRT <213> turkey adenovirus A <400> 6 Met Ser Lys Tyr Ile Tyr Thr Thr Gln Asn Glu Ile Pro Tyr Arg Leu 1 5 10 15 Gln Ile Cys Lys Lys Asp Ile Lys Ala Thr Ile Ile Glu Ile Ala Trp 20 25 30 Thr Tyr Asn Leu Phe Asn Cys Lys Lys Leu Ala Lys Lys Val Lys Asp 35 40 45 Ala Gln Ser Tyr Ile Leu Ile Cys Ser Lys Tyr Lys Pro Thr Asn Ser 50 55 60 Asp Ile Glu Asn Val Lys Asn Leu Pro Val Lys Ser Ile Thr Ile Trp 65 70 75 80 Lys Lys Leu Thr Gly Cys Val Met Ile Gln Asn Glu Phe Lys Thr Ser 85 90 95 His Glu Tyr Ile Glu Leu Asp Phe Ile Tyr Asp Lys Ser Lys Leu Cys 100 105 110 Trp Ile Lys Ser Trp Thr Gln Gln Gln Lys Cys Ser Ser Cys Gly Arg 115 120 125 Ile Tyr Ser Ala Ile His Thr Cys Asn Asp Leu Arg Ser Thr Tyr Tyr 130 135 140 Tyr Asn Ser Val Asp Asn Asp Thr Arg Lys Phe Trp Glu Thr Ile Pro 145 150 155 160 Phe Gln Pro Ile Gly Glu Asn Glu Asn Thr Lys Lys Leu Phe Leu Ile 165 170 175 Tyr Asp Ile Glu Thr Phe Thr Leu Ala Glu Thr Ser Gly Val Leu Leu 180 185 190 Asn Pro Leu Leu Leu Cys Phe Ser Ile Phe Gly Asp Asp Cys Leu Ile 195 200 205 Asn Ile Cys Lys Thr Glu Ile Ala Lys Ile Lys Ser Ile Gln Thr Lys 210 215 220 Asn Ser Thr Tyr Phe Trp Phe Ser Lys Val Lys Asn Phe Ile Ser Thr 225 230 235 240 Glu Phe Arg Lys Leu Arg Asn Asn Ile Leu Phe Ala Leu Thr Asp Tyr 245 250 255 Phe Thr Lys Leu Ile Leu Thr Pro Glu Asn Arg Glu Ile Leu Glu Asp 260 265 270 Phe Ala Gln Thr Gln Asn Leu Glu Ser Ile Thr Asn Ile Asn Leu Ser 275 280 285 Glu His Thr Asn Leu Ile Met Ser Leu Lys Val Lys Pro Ile Phe Ile 290 295 300 Glu Phe Tyr Ile Ile Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu 305 310 315 320 Leu Ala Thr Gln Ile Leu Gln Asp Glu Asn Leu Asp Ile Thr Pro Leu 325 330 335 Phe Thr Val Glu Arg Asn Phe Met Pro Arg Gln Gly Arg Ile Leu Phe 340 345 350 Asn Asp Ile Thr Ile Lys Phe Pro Asn Pro Asp Tyr Tyr Val Ala Lys 355 360 365 Glu Glu Lys Lys Asn Asn Lys Ser Glu Ile Leu Ser Gln Ile Lys Glu 370 375 380 Gly Ile Pro His Pro Glu Ser Ile Lys Asn Leu Tyr Ile Lys Ser Met 385 390 395 400 Val Arg Asp Thr Phe Gln Ile Thr His Thr Ser Leu Lys Glu Ala Ala 405 410 415 Lys Ala Tyr Asn Leu Lys Ile His Lys Gly Cys Cys Pro Phe Lys Ala 420 425 430 Ile Asn Glu Tyr Met Ser Thr Asn Ser Leu Ser Thr Asp Ser Asp Ser 435 440 445 Phe Pro Ser Glu Lys Tyr Trp Ser Ser Lys Glu Glu Tyr Asn Glu Gln 450 455 460 Lys Glu Ile Trp Leu Glu Lys Lys Glu Val Lys Tyr Asp Ile Val Lys 465 470 475 480 Glu Leu Ile Asp Tyr Cys Ile Lys Asp Val Lys Ile Thr Glu Glu Leu 485 490 495 Thr Lys Thr Leu Leu Asn Thr Phe Asp Thr Phe Ile Lys Glu Glu Leu 500 505 510 Asn Leu Lys Cys Asn Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser Ser 515 520 525 Asn Ser His Ala Ile Phe Arg Gln Leu His Phe Lys Gln Asn Gly Thr 530 535 540 Lys Ala Ser Thr Leu Pro Asp Ile Val Ala Pro Ser Asp Glu Met Tyr 545 550 555 560 Ser Phe Ile Arg Gln Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr His 565 570 575 Leu Gly Ile Phe Lys Glu Lys Ile Phe Val Tyr Asp Ile Cys Gly Met 580 585 590 Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Phe Pro Ile Gly 595 600 605 Glu Lys Glu Arg Asn Asn Glu Ile Thr Lys Leu Asn Glu Lys Leu Lys 610 615 620 Lys Thr Lys Thr Lys Leu Ser Tyr Phe Thr Asp Ile Lys Pro Met Val 625 630 635 640 Val Met Ile Asp Ala Ile Pro Pro Pro Pro Glu His Leu Asp Pro Leu 645 650 655 Pro Pro Leu Cys Ser Arg Gln Ser Gly Lys Leu Cys Trp Thr Asn Glu 660 665 670 Ile Leu Lys Asn Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His 675 680 685 Asn Arg Gly Trp Lys Val Asn Ile Ile Pro His Lys Leu Asn Thr Val 690 695 700 Phe Pro Thr Trp Asn Thr Cys Cys Leu Glu Tyr Val Thr Lys Asn Ile 705 710 715 720 Leu Ala Lys Glu Lys Ala Thr Val Glu Lys Asn Pro Val Lys Arg Ala 725 730 735 Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg 740 745 750 Glu Ser Asn Asp Ile Thr Ile Phe Glu Asn His Ile Gln Glu Asn Pro 755 760 765 Lys Ile Arg Asn Gln Leu Leu Asn Lys Gln Leu Thr Ile Asp Ser Ile 770 775 780 Thr Thr Leu Pro Thr Tyr Asn Leu Pro Tyr Val Ser Ile Glu Asn Leu 785 790 795 800 Thr Phe Thr Leu Lys Asn Arg Thr Asp Ser Ala Glu Arg Asn Leu Glu 805 810 815 Leu Asp Asp Glu Leu Thr Ser Pro Phe Asn Ser Leu Glu Phe Met Asp 820 825 830 Glu Ser Pro Ala Ser Gln Thr Ser Thr Ser Thr Ala His Val Gly Thr 835 840 845 Tyr Lys Pro Phe Asn Ile Leu Asp Val Thr Ser Glu Asn Leu Thr Ile 850 855 860 Tyr Met Leu Lys Ser Thr Asn Leu His Pro Thr Asn Lys Arg Tyr Pro 865 870 875 880 Thr Gln Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser 885 890 895 Glu Trp Arg Glu Ile Leu Tyr Ser Asp Glu Asp Ser Ile Pro Val Gln 900 905 910 Phe Lys Thr Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu 915 920 925 Thr Glu Lys Gly His Gln Asn Met Leu Lys Tyr Gly Gln His Arg Ile 930 935 940 Lys Asn Lys Asn Ser Gln Leu Thr Phe Asp Pro Lys Lys Pro Ser Ile 945 950 955 960 Val Trp Ala Val Glu Cys Glu Thr Trp Cys Asn Leu Cys Asn Ser Pro 965 970 975 Ala Tyr Ser Ser Lys Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu 980 985 990 Lys Glu Ile Thr Cys Thr Thr Cys Lys Asn Ser Lys Thr Gly Lys Leu 995 1000 1005 Arg Ala Lys Gly His Cys Thr Ala Asp Ile Thr Phe Glu Ile Leu 1010 1015 1020 Glu Glu Cys Phe Asn Tyr His Thr Ser Glu Leu Lys Ser Gly Glu 1025 1030 1035 Ile Phe Gln Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Cys Lys 1040 1045 1050 Ser Tyr Gly Lys Phe Ser Pro Phe Ser Val His Glu Ile Gln Leu 1055 1060 1065 Ile Arg Glu Leu Arg Pro Trp Asn Asp Pro Thr Leu Tyr Phe Leu 1070 1075 1080 Lys Thr Asn Thr Leu Ile Pro Tyr Asp Leu Tyr His Pro Asn Pro 1085 1090 1095 Arg Ile Thr Asn Pro Ile Leu Leu Gln Glu Phe Glu Asp Glu 1100 1105 1110 <210> 7 <211> 1108 <212> PRT <213> Great tit adenovirus <400> 7 Met Ser Tyr Met Tyr Val Thr Gln Asn Glu Thr Pro Tyr Arg Leu Ser 1 5 10 15 Ile Ser Lys Lys Ser Ile Lys Glu Thr Leu Leu Glu Ile Cys Trp Asn 20 25 30 Phe Asn Phe Phe His Cys Lys Lys Ile Cys Lys Lys Leu Lys Gln Cys 35 40 45 Glu Ser Tyr Ile Leu Val Cys Cys Lys Phe Lys Glu Gln Asn Thr Ala 50 55 60 Ile Glu Asn Ile Lys Gln Leu Pro Ala Gln Lys Ile Thr Ile Trp Lys 65 70 75 80 Lys Leu Thr Gly Cys Ile Val Ile Gln Gln Glu Ile Thr Asn Ser Thr 85 90 95 Ala Ser Ser Ile Gln Leu Asp Phe Val Gln Thr Lys Asp Gly Leu Lys 100 105 110 Trp Ile Lys Thr Trp Thr Lys Gln Gln Lys Cys Thr Ser Cys Gly Arg 115 120 125 Ile Tyr Val Thr Ser His Thr Cys Asp Tyr Asn Arg Ser Ser Phe Tyr 130 135 140 Tyr Asn Gln Ile Ala Ser Ser Lys Lys Tyr Trp Glu Ser Ile Gln Phe 145 150 155 160 Gln Pro Ile Gly Glu Thr Glu Asn Thr Phe Lys Leu Phe Leu Val Tyr 165 170 175 Asp Ile Glu Thr Tyr Thr Leu Ala Glu Ser Glu Gly Ile Asn Leu Gln 180 185 190 Pro Cys Leu Leu Cys Phe Thr Ile Phe Gly Glu Gln Glu Leu Thr Lys 195 200 205 Ile Ala Met Glu Glu Ile Asn Arg Asp Arg Thr Ile Thr His Ser Asn 210 215 220 Asp Asn Ile Phe Tyr Trp His Ser Lys Thr Lys Asn Phe Ile Ser Gln 225 230 235 240 Gln Phe Arg Leu Leu Arg Glu Asn Ile Leu Asn Arg Met Ile Gln Val 245 250 255 Leu Thr Thr His Ile Leu Ser Lys Glu Asn Lys Glu Val Leu Asp Asp 260 265 270 Phe Ile Lys Leu Lys Lys Leu Gln Thr Tyr Lys Asp Ile Asp Ile Ser 275 280 285 Lys Glu Lys Asn Leu Leu Leu Ser Leu Thr Ile Lys Pro Ile Phe Leu 290 295 300 Glu Phe Tyr Val Val Gly His Asn Ile Gln Ser Phe Asp Glu Ile Leu 305 310 315 320 Leu Ala Thr Gln Ile Leu Gln Pro Asn Lys Phe Gln Tyr Glu Pro Phe 325 330 335 Leu Thr Ile Ser Arg Asn Phe Met Pro Arg Gln Gly Lys Ile Leu Phe 340 345 350 Asn Asp Ile Thr Ile Thr Phe Pro Asn Pro Glu Tyr His Ile Ala Asp 355 360 365 Glu Gly Lys Glu Asn Lys Thr Ala Glu Ile Ile Ala Asp Ala Arg Glu 370 375 380 Gly Lys Pro Asn Val Lys Asn Ile Lys His Leu Tyr Val Lys Ser Met 385 390 395 400 Val Arg Asp Thr Phe Gln Ile Thr His Ser Ser Leu Lys Thr Ala Ala 405 410 415 Glu Ala Tyr Asn Leu Pro Thr Ser Lys Gly Cys Cys Pro Phe Lys Ala 420 425 430 Ile Asn Asp Phe Tyr Ser Leu Gly Ser Tyr Arg Gly Glu Ser Glu Thr 435 440 445 Asn Phe Pro Val Val Thr Tyr Trp Ser Cys Glu Asp Glu Tyr Lys Glu 450 455 460 Gln Leu Glu Ile Trp Lys Gln Lys Gln Glu Lys Asn Tyr Asp Ile Val 465 470 475 480 Lys Glu Leu Ile Glu Tyr Cys Cys Arg Asp Val Leu Val Thr Val Ser 485 490 495 Leu Thr Lys Cys Leu Leu Glu Thr Phe Asn Ser Phe Val Thr His Glu 500 505 510 Phe Asn Leu Asn Cys Thr Phe Asn Ile Phe Lys Arg Pro Thr Ile Ser 515 520 525 Ser Asn Ser His Ala Ile Phe Arg Gln Ile His Tyr Lys Glu Tyr Gly 530 535 540 Asn Lys Leu Asn Gln Leu Pro Asp Ile Tyr Ala Pro Ser Glu Glu Met 545 550 555 560 Tyr Glu Phe Ile Arg Lys Ser Val Arg Gly Gly Arg Cys Tyr Pro Thr 565 570 575 Phe Leu Gly Arg Phe Ala Glu Lys Leu Tyr Val Tyr Asp Ile Cys Gly 580 585 590 Met Tyr Ala Ser Ala Leu Thr His Pro Leu Pro Tyr Gly Thr Pro Val 595 600 605 Gly Lys Glu Glu Arg Asp His Glu Ile Lys Lys Phe Asn Gln Leu Leu 610 615 620 Ser Ser Lys Asp Glu Ile Ser Tyr Phe Ala Asp Ile Lys Pro Met Ile 625 630 635 640 Val Cys Ile Asn Ala Phe Pro Pro Pro Pro Glu Leu Leu Asp Pro Leu 645 650 655 Pro Pro Leu Cys Ser Lys Ala Ser Gly Lys Leu Cys Trp Thr Asn Glu 660 665 670 Pro Leu His Lys Glu Ile Val Thr Ser Ile Asp Ile Ile Thr Leu His 675 680 685 Asn Arg Arg Trp Ser Val Ser Ile Leu Gln His Pro Leu Asn Thr Val 690 695 700 Phe Ser Ser Trp Lys Thr Cys Cys Ser Asn Tyr Val Lys Ala Asn Ile 705 710 715 720 Gln Ala Lys Glu Lys Ala Ser Lys Glu Lys Asn Pro Val Lys Arg Ala 725 730 735 Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys 740 745 750 Glu Asp Asn Asp Met Val Ile Phe Glu Gln Ser Leu Thr Asp Lys Ile 755 760 765 Lys His Gln Ile Ser Gln Asn Glu Leu Gln Ile Thr Asn Ile Thr Ser 770 775 780 Ile Pro Thr Glu Gln Leu Pro Ser Thr Cys Tyr Thr Asn Ile Gln Tyr 785 790 795 800 Phe Leu Lys Ser Lys Leu Pro Asp His Arg Ala Asn Gln Gln Ala Asp 805 810 815 Asp Glu Leu Thr Ser Pro Phe Glu Ala Val Pro Glu Glu Gln Pro Glu 820 825 830 Pro Ser Phe Cys Ser Thr Gln Thr His Met Thr Thr Tyr Lys Pro Phe 835 840 845 Asn Ile Leu Asp Val Thr Ser Asp Asn Leu Thr Ile Tyr Met Leu Lys 850 855 860 Ser Thr Lys Pro His Pro Thr Asn Lys Arg Tyr Pro Thr Gln Leu Ala 865 870 875 880 Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Ile Ser Glu Trp Ala Glu 885 890 895 Ile Leu Tyr His Asp Glu Asn Asn Ile Pro Ile Glu Asn Lys Ser Leu 900 905 910 Lys Ala Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Ala Gly 915 920 925 His Arg Leu Met Leu Ser Lys Gly Asn Tyr Arg Leu Lys Ser Asp Lys 930 935 940 Thr Pro Leu Ile Phe Asn Pro Glu Ala Pro Lys Leu Thr Trp Ala Val 945 950 955 960 Glu Cys Glu Thr Glu Cys Asn Val Cys Lys Lys Pro Gly Phe Cys Pro 965 970 975 Asp Ser Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Lys Ile Phe 980 985 990 Cys Pro Ser Cys Asn Thr Glu Phe Gly Gly Lys Leu Arg Ala Lys Gly 995 1000 1005 His Ala Thr Thr His Leu Thr Phe Glu Ile Leu Leu Glu Cys Phe 1010 1015 1020 Asn Cys His Lys Thr Cys Ser Gly Pro Ala Arg Lys Phe Thr Thr 1025 1030 1035 Glu Arg Arg Ala Leu Lys Arg Thr Ile His Lys Pro Tyr Gly Gln 1040 1045 1050 Phe Ser Pro Phe Thr Ile His Glu Ile Asn Leu Ile Arg Glu Leu 1055 1060 1065 Arg Pro Trp His Asp Pro Thr Leu Val Phe Ile Thr Asp Lys Val 1070 1075 1080 Leu Ile Pro Tyr Asp Leu Gln His Arg Asn Pro Arg Val Thr Ala 1085 1090 1095 Pro Ile Leu Ile Glu Glu Phe Glu Asp Glu 1100 1105 <210> 8 <211> 1108 <212> PRT <213> frog adenovirus 1 <400> 8 Met Ser Ala Phe Gly Ser Ile Glu Asn Asp His Phe Arg Leu Lys Leu 1 5 10 15 Asn Ser Lys Pro Ala Lys Leu Ala Ile Leu Asp Ile Cys Trp Gln Phe 20 25 30 Asn Leu Phe Asn Cys Lys Lys Phe Lys His Lys Lys His Ile Ala Ser 35 40 45 Leu Ile Tyr Ser Gln Cys Ser Tyr Asn Ser Asn Lys Ser Leu Tyr Glu 50 55 60 Leu Cys Lys Thr Leu Pro Ile Lys Thr Leu Gln Leu Trp Lys Ile Gln 65 70 75 80 Lys Gly Ser Ile Ile Arg Thr Gln Lys Leu Asp Leu Asp Gln Gly Glu 85 90 95 Ile Ile Ile Asp Leu Leu Ser Pro Lys His Leu Trp Ile Val Glu Trp 100 105 110 Phe Glu Gln Asn Lys Cys Lys Asn Cys Gly Arg Phe Phe Ser Tyr Asn 115 120 125 His Val Cys Asn Thr Asn Arg Ala Ser Tyr Tyr Tyr His Lys Ile Ala 130 135 140 Asn Thr Lys Thr Gln Trp Glu Thr Ile Asn Phe Ser Pro Ile Gly Glu 145 150 155 160 Pro Lys Gly Thr Lys Lys Leu Phe Leu Val Tyr Asp Ile Glu Thr Tyr 165 170 175 Thr Lys Ala Cys Pro Val Gly Tyr Lys Leu Cys Pro Val Leu Leu Cys 180 185 190 Phe Thr Ile Phe Gly Asp Glu Thr Leu Asn Lys Glu Val His Glu Leu 195 200 205 Ile Ser Ser Asn Ser Asn Ile Leu Glu Leu Asn Asn Leu Gly Glu Cys 210 215 220 Phe Tyr Trp Leu Ser Lys Glu Thr Asn Tyr Ile Ser Ser Lys Phe Arg 225 230 235 240 Lys Thr Arg Leu Leu Ile Gln Asn Phe Leu Ile Glu Lys Met Ile Lys 245 250 255 Asn Phe Leu Thr Glu Glu Asn Lys Glu Ile Leu Thr Asp Tyr Ala Lys 260 265 270 Ala His Asn Tyr Glu Ser Ile Tyr Glu Ile Asp Leu Leu Lys Asp Lys 275 280 285 Asn Leu Ile Leu Thr Leu Gln Ala Pro Phe Ile Asn Leu Glu Phe Tyr 290 295 300 Val Ile Gly His Asn Ile Ser Ser Phe Asp Glu Ile Leu Leu Ala His 305 310 315 320 Gln Ile Leu Gln Lys Asp Thr Thr Thr Ile Pro Gln Pro Phe Ile Gln 325 330 335 Ile Lys Arg Asn Phe Leu Pro Arg Gln Gly Lys Ile Leu Phe Asn Asp 340 345 350 Ile Thr Phe Ser Leu Pro Tyr Pro Glu Tyr Tyr Val His Glu Glu Glu 355 360 365 Asn Thr Leu Thr Lys Lys Glu Ala Ile Glu Ile Glu Lys Thr Gly Glu 370 375 380 Pro Ser Leu Phe Arg Thr Lys Glu Ile Cys Val Lys Thr Met Val Arg 385 390 395 400 Asp Thr Tyr Gln Leu Thr His Cys Ser Leu Arg Leu Ala Ala Glu Ala 405 410 415 Tyr Gly Leu Lys Thr Thr Lys Gly Asn Cys Pro Phe Lys Ala Val Thr 420 425 430 Glu Phe Tyr Ser Val Asn Ser Phe Asp Lys Asp Lys Phe Gly Phe Pro 435 440 445 Ala Pro Lys Tyr Trp Thr Asp Asn Glu Glu Tyr Met Thr Gln Leu Lys 450 455 460 Ile Trp Gln Gln Asn Asp Glu Pro Tyr Asp Leu Gln Lys Glu Leu Ile 465 470 475 480 Lys Tyr Cys Ala Gln Asp Val Asn Val Thr Lys Asn Leu Thr Ile Ser 485 490 495 Ile Leu Asn Ser Tyr Asn Glu Phe Ile Lys Glu Asn Phe Lys Leu Thr 500 505 510 Cys Asn Tyr Asn Val Phe Lys Arg Pro Thr Ile Pro Ser Asn Ser Gln 515 520 525 Ala Ile Phe Lys Gln Leu Leu Tyr Lys Lys His Gly Lys Lys Phe Gly 530 535 540 Lys Met Pro Asp Ile Met Ala Pro Ser Ala Glu Met Tyr Glu Phe Val 545 550 555 560 Arg Glu Ser Val Arg Gly Gly Arg Cys Tyr Pro Ser Leu Leu Gly Glu 565 570 575 Ile Lys Glu Pro Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser 580 585 590 Ala Leu Thr His Pro Met Pro Phe Gly Val Pro Leu Ser Gln Lys Glu 595 600 605 Lys Asn Gln Glu Ile His Ile Leu Gln Ser Lys Leu Gln Asn Glu Lys 610 615 620 Thr Leu Asn Tyr Phe Asp Pro Glu Ile Lys Pro Met Ile Ile Ser Ile 625 630 635 640 Ser Ala Phe Pro Pro Pro Val Glu Tyr Leu Thr Asn Ile Pro Pro Ile 645 650 655 Cys Ser Arg Lys Ser Gly Arg Leu Cys Trp Thr Asn Glu Ala Leu Tyr 660 665 670 Asp Glu Thr Val Thr Ile Val Asp Val Ile Thr Leu His Asn Cys Gly 675 680 685 Trp Lys Val Lys Ile Glu Asp His Pro Leu Asn Thr Val Phe Pro Asn 690 695 700 Trp Asn Thr Cys Cys Lys Glu Tyr Val Glu Val Asn Ile Ala Ala Lys 705 710 715 720 Glu Lys Ala Asp Lys Asp Lys Asn Gln Ile Met Arg Ser Ile Ser Lys 725 730 735 Leu Leu Ser Asn Ser Leu Tyr Gly Ser Phe Ala Thr Lys Glu Asp Asn 740 745 750 Ser Met Ile Val Phe Glu His Met Leu Lys Ser Asn His Ile Lys Thr 755 760 765 Lys Leu Glu Gln Asn Glu Ile Lys Ile Asp Ala Val Phe Gly Ile Pro 770 775 780 Thr Asn Gly Ile Glu His Thr Thr Ile Asp Asn Lys Leu Phe Tyr Leu 785 790 795 800 Ser Asn Thr Asn Thr Leu Asn Asp Ser Asn Ala Pro Pro Ile Asp Asp 805 810 815 Glu Leu Leu Thr Pro Phe Ser Glu Glu Ala Tyr Ala Glu Glu Glu Val 820 825 830 Glu Gln Leu Ala Pro Glu Asn Ser Asn Cys His Val Arg Thr Tyr Gln 835 840 845 Pro Phe Thr Leu Ile Asp Val Asp Thr Glu Asp Leu Thr Leu Tyr Ser 850 855 860 Leu Lys Ser Asn Lys Lys Phe Thr Glu Asn Lys Arg Tyr Pro Thr Gln 865 870 875 880 Leu Ala Ser Phe Val Leu Ser Trp Thr Arg Ala Phe Met Ala Asp Trp 885 890 895 Asn Ala Ile Leu Tyr Glu Lys Asp Ser Lys Ser Ile Leu Val Lys Glu 900 905 910 Leu Asn Ala Ile Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Lys 915 920 925 Gly His Lys Arg Met Ile Asp His Gly Gln His Arg Leu Lys Glu Asn 930 935 940 Val Lys Ser Leu Val Phe Gln Glu Cys Cys Pro Asp Ile Thr Trp Ala 945 950 955 960 Val Glu Cys Glu Thr Lys Cys Pro Asn Cys Lys Ser Ser Ala Phe Ser 965 970 975 Asn Arg Thr Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Arg Ile 980 985 990 Val Cys Asn Ser Cys Asn Thr Glu Thr Glu Gly Lys Leu Arg Ala Lys 995 1000 1005 Gly His Ala Lys Asn Asp Met Thr Phe Glu Leu Leu Cys Thr Cys 1010 1015 1020 Phe Glu Tyr His Lys Asn Cys His Thr Lys Gly Lys Arg Phe Ser 1025 1030 1035 Thr Glu Arg Thr Ala Leu Lys Arg Thr Leu Tyr Lys Pro Tyr Gly 1040 1045 1050 Lys Phe Glu Pro Phe Thr Ile His Gln Val Arg Leu Ile Arg Glu 1055 1060 1065 Leu Arg Pro Trp His Asp Pro Thr Met Leu Glu Arg Asp Asp Gly 1070 1075 1080 Phe Leu Ile Pro Tyr Tyr Val Gly His Pro Asn Pro Arg Asp Lys 1085 1090 1095 Arg Val Lys Tyr Leu Glu Asp Ile Asp Gly 1100 1105 <210> 9 <211> 1255 <212> PRT <213> fowl adenovirus 1 <400> 9 Met Glu Ala Asp Ala Gly Pro Pro Leu Thr Asp Ser Val Leu Gly Pro 1 5 10 15 Asp Ser His Val Ile Arg Thr Ile Ser Ala Lys Arg Leu Glu Glu Thr 20 25 30 Arg Lys Tyr Phe Lys Ser Phe Arg Gly Asn Pro Leu Arg Thr Asn Val 35 40 45 Tyr Tyr Ile Glu Glu Gln Pro Phe Arg Phe Gln Pro Thr Val Phe Pro 50 55 60 Ile Gly Leu Lys Lys Phe Leu Arg Thr His Arg Phe Leu Leu Ser Lys 65 70 75 80 Arg Ala Arg Gly Tyr Asp Arg Ile Asp Tyr Leu His Tyr Ala Arg Asp 85 90 95 Pro Glu Arg Ser Leu Pro Asp Phe Lys Pro Ala Gln Val Thr Val Ile 100 105 110 Asp Phe Lys Gly Lys Thr Ala Arg Leu Arg Thr Val His Ile Ser Glu 115 120 125 His Pro Ala Leu Pro Pro Met Leu Ile Ala Lys Asn Val Thr Gly Glu 130 135 140 Trp Val Trp Ile Thr Ser Arg Thr Pro Val Gln Gln Cys Pro Thr Cys 145 150 155 160 Gly Arg His Trp Val Arg Arg His Ser Cys Asn Glu Arg Arg Ser Ala 165 170 175 Phe Tyr Tyr His Ala Val Gln Gly Ser Gly Ser Asp Leu Trp Gln His 180 185 190 Val His Phe Ser Cys Pro Ala Gln His Pro His Ile Arg Gln Leu Tyr 195 200 205 Ile Thr Tyr Asp Ile Glu Thr Tyr Thr Val Phe Glu Lys Lys Gly Lys 210 215 220 Arg Met His Pro Phe Met Leu Cys Phe Met Leu Ser Gly Asp Pro Gln 225 230 235 240 Leu Val Ser Arg Ala Glu Arg Leu Ala Arg Gln Asp Asp Arg Leu Lys 245 250 255 Ala Leu Asp Glu Gly Phe Tyr Trp Leu Asp Ser His Pro Gly Glu Val 260 265 270 Ala Arg Arg Phe Arg Asn Phe Arg Ser Arg Leu Gln Ile Glu Phe Ala 275 280 285 Gln Asn Leu Val Asp Arg Tyr Ala Ala Ala Asn Arg Asp Tyr Cys Asp 290 295 300 Gln Leu Val Lys Asp Gly Lys Tyr Gly Ser Val His Lys Ile Pro Tyr 305 310 315 320 Glu Leu Phe Glu Lys Pro Thr Ser Pro Leu Ser Leu Pro Asp Asn Phe 325 330 335 Tyr Ser Val Asp Ile Val Val Leu Gly His Asn Ile Cys Lys Phe Asp 340 345 350 Glu Leu Leu Leu Ala Thr Glu Leu Val Glu Arg Arg Asp Leu Phe Pro 355 360 365 Glu Ala Cys Lys Cys Asp Arg Ser Phe Met Pro Arg Val Gly Arg Leu 370 375 380 Leu Phe Asn Asp Ile Ile Phe Arg Met Pro Asn Pro Asn Tyr Val Lys 385 390 395 400 Lys Asp Ala Ser Arg Val Glu Arg Trp Ser Arg Gly Ile Val Ser Gln 405 410 415 Gln Asp Ala Arg Ser Val Phe Val Arg Phe Met Val Arg Asp Thr Leu 420 425 430 Gln Leu Thr Ser Gly Ala Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala 435 440 445 Leu Asp Leu Cys Lys Gly Gln Cys Pro Tyr Glu Ala Ile Asn Glu Phe 450 455 460 Ile Ser Thr Gly Arg Phe His Ala Asp Ala Asp Gly Phe Pro Val Glu 465 470 475 480 Arg Tyr Trp Glu Asp Pro Ser Val Ile Ala Glu Gln Lys Asn Leu Trp 485 490 495 Gln Lys Glu His Pro Gly Gln Gln Tyr Asp Ile Val Gln Ala Cys Leu 500 505 510 Glu Tyr Cys Met Gln Asp Val Arg Val Thr Gln Lys Leu Ala His Thr 515 520 525 Leu His Asp Ser Tyr Asp Ala Tyr Phe Gln Arg Glu Leu Gly Met Glu 530 535 540 Gly His Phe Asn Ile Phe Val Arg Pro Thr Ile Pro Ser Asn Thr His 545 550 555 560 Ala Phe Trp Lys Gln Leu Thr Phe Ser Asn Tyr Val Arg Glu Gln Arg 565 570 575 Ala Thr Cys Pro Pro Ser Val Pro Glu Pro His Lys Lys Lys Gly Arg 580 585 590 Thr Lys Lys Lys Lys Gln Pro Ser Pro Asp Tyr Val Ala Glu Val Tyr 595 600 605 Ala Pro His Arg Pro Met Phe Lys Tyr Ile Arg Gln Ala Leu Arg Gly 610 615 620 Gly Arg Cys Tyr Pro Asn Val Leu Gly Pro Tyr Leu Lys Pro Val Tyr 625 630 635 640 Val Phe Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met 645 650 655 Pro His Gly Met Pro Leu Asp Pro Lys Phe Thr Ala Gln His Val Gly 660 665 670 Glu Leu Asn Arg Leu Leu Thr Asn Glu Ser His Leu Ser Tyr Phe Asp 675 680 685 Ala Arg Ile Lys Pro Ser Ile Leu Lys Ile Glu Ala Tyr Pro Pro Pro 690 695 700 Pro Glu Met Leu Asp Pro Leu Pro Pro Ile Cys Ser Arg Arg Gly Gly 705 710 715 720 Arg Leu Val Trp Thr Asn Glu Ala Leu Tyr Asp Glu Val Val Thr Val 725 730 735 Ile Asp Ile Leu Thr Leu His Asn Arg Gly Trp Arg Val Gln Val Leu 740 745 750 His Asp Glu Met Asn Ile Val Phe Pro Glu Trp Lys Thr Leu Cys Ala 755 760 765 Asp Tyr Val Thr Lys Asn Ile Leu Ala Lys Glu Lys Ala Asp Arg Glu 770 775 780 Lys Asn Glu Val Ile Arg Ser Ile Ser Lys Met Leu Ser Asn Ala Leu 785 790 795 800 Tyr Gly Ala Phe Ala Thr Asn Met Asp Thr Thr Arg Ile Ile Phe Glu 805 810 815 Gln Asp Leu Ser Glu Ala Asp Lys Lys Asn Ile Tyr Glu Gly Thr Glu 820 825 830 Ile Val Lys His Val Thr Leu Leu Asn Asp Asp Ser Phe Asn Gly Thr 835 840 845 Glu Val Thr Leu Glu Ser Ala Pro Asn Pro Phe Ser Glu Glu Ser Leu 850 855 860 Arg Gln Gln Phe Arg Tyr Ala Asp Asp Pro Glu Gln Glu Glu Pro Glu 865 870 875 880 Ala Glu Glu Asp Glu Glu Glu Glu Gly Asp Asp Ser Asp Arg Glu Ser 885 890 895 Ala Arg Lys Pro Lys Asn Ala Leu Thr Glu Asp Asp Pro Leu Val Ala 900 905 910 Val Asp Leu Glu Val Glu Ala Thr Leu Ala Thr Gly Pro Tyr Ile Pro 915 920 925 Glu Gly Glu Leu Ser Ser Ala His Tyr Ala Arg Ala Asn Glu Thr Arg 930 935 940 Phe Lys Pro Met Arg Leu Leu Glu Ala Thr Pro Glu Ala Leu Thr Val 945 950 955 960 Leu His Leu Glu Asn Leu Asp Lys Gln Val Ala Asn Lys Arg Tyr Ala 965 970 975 Thr Gln Ile Ala Cys Phe Val Leu Gly Trp Ser Arg Ala Phe Phe Ser 980 985 990 Glu Trp Cys Asp Ile Leu Tyr Gly Pro Asp Arg Gly Val His Ile Leu 995 1000 1005 Arg Arg Glu Glu Pro Arg Ser Leu Tyr Gly Asp Thr Asp Ser Leu 1010 1015 1020 Phe Val Thr Glu Thr Gly Tyr His Arg Met Lys Ser Arg Gly Ala 1025 1030 1035 His Arg Ile Lys Thr Glu Ser Thr Arg Leu Thr Phe Asp Pro Glu 1040 1045 1050 Asn Pro Gly Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys Lys 1055 1060 1065 Ala Cys Gly Ser Asp Thr Tyr Ser Ser Glu Thr Ile Phe Leu Ala 1070 1075 1080 Pro Lys Leu Tyr Gly Leu Lys Asn Ser Ile Cys Val Asn Glu Gln 1085 1090 1095 Cys Arg Thr Val Gly Pro Gly Lys Ile Arg Ser Lys Gly His Arg 1100 1105 1110 Gln Ser Glu Leu Ile Tyr Asp Thr Leu Leu Arg Cys Trp Arg Arg 1115 1120 1125 His Glu Asp Val Gln Phe Gly Ala Gln Ser Asn Ile Pro Glu Leu 1130 1135 1140 His Thr Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val 1145 1150 1155 Ser Arg Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg 1160 1165 1170 Val Leu Arg Pro Trp Lys Asp Leu Thr Leu Tyr Glu His Gly Asp 1175 1180 1185 Tyr Leu Tyr Pro Tyr Asp Asn Glu His Pro Asn Pro Arg Thr Ala 1190 1195 1200 Gly Asp Val Arg Pro Val Pro Ile Val Gly His Glu Asp Pro Leu 1205 1210 1215 Ala Pro Leu Arg Trp Glu Pro Tyr Ala Phe Leu Ser Glu Glu Glu 1220 1225 1230 Cys Gly Gln Val His Asp Leu Leu Phe Ala Asp Asp Ser Ser Gln 1235 1240 1245 Glu Ala Glu Ser Leu Gly Val 1250 1255 <210> 10 <211> 1121 <212> PRT <213> Fowl adenovirus A <400> 10 Met Leu Ile Ala Lys Asn Val Thr Gly Glu Trp Val Trp Ile Thr Ser 1 5 10 15 Arg Thr Pro Val Gln Gln Cys Pro Thr Cys Gly Arg His Trp Val Arg 20 25 30 Arg His Ser Cys Asn Glu Arg Arg Ser Ala Phe Tyr Tyr His Ala Val 35 40 45 Gln Gly Ser Gly Ser Asp Leu Trp Gln His Val His Phe Ser Cys Pro 50 55 60 Ala Gln His Pro His Ile Arg Gln Leu Tyr Ile Thr Tyr Asp Ile Glu 65 70 75 80 Thr Tyr Thr Val Phe Glu Lys Lys Gly Lys Arg Met His Pro Phe Met 85 90 95 Leu Cys Phe Met Leu Ser Gly Asp Pro Gln Leu Val Ser Arg Ala Glu 100 105 110 Arg Leu Ala Arg Gln Asp Asp Arg Leu Lys Ala Leu Asp Glu Gly Phe 115 120 125 Tyr Trp Leu Asp Ser His Pro Gly Glu Val Ala Arg Arg Phe Arg Asn 130 135 140 Phe Arg Ser Arg Leu Gln Ile Glu Phe Ala Gln Asn Leu Val Asp Arg 145 150 155 160 Tyr Ala Ala Ala Asn Arg Asp Tyr Cys Asp Gln Leu Val Lys Asp Gly 165 170 175 Lys Tyr Gly Ser Val His Lys Ile Pro Tyr Glu Leu Phe Glu Lys Pro 180 185 190 Thr Ser Pro Leu Ser Leu Pro Asp Asn Phe Tyr Ser Val Asp Ile Val 195 200 205 Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr 210 215 220 Glu Leu Val Glu Arg Arg Asp Leu Phe Pro Glu Ala Cys Lys Cys Asp 225 230 235 240 Arg Ser Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Ile Ile 245 250 255 Phe Arg Met Pro Asn Pro Asn Tyr Val Lys Lys Asp Ala Ser Arg Val 260 265 270 Glu Arg Trp Ser Arg Gly Ile Val Ser His Gln Asp Ala Arg Ser Val 275 280 285 Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Leu Thr Ser Gly Ala 290 295 300 Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Asp Leu Cys Lys Gly 305 310 315 320 His Cys Pro Tyr Glu Ala Ile Asn Glu Phe Ile Ser Thr Gly Arg Phe 325 330 335 His Ala Asp Ala Asp Gly Phe Pro Val Glu Arg Tyr Trp Glu Asp Pro 340 345 350 Ser Val Ile Ala Glu Gln Lys Asn Leu Trp Gln Lys Glu His Pro Gly 355 360 365 Gln Gln Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp 370 375 380 Val Arg Val Thr Gln Lys Leu Ala His Thr Leu His Asp Ser Tyr Asp 385 390 395 400 Ala Tyr Phe Gln Arg Glu Leu Gly Met Glu Gly His Phe Asn Ile Phe 405 410 415 Val Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu 420 425 430 Thr Phe Ser Asn Tyr Val Arg Glu Gln Arg Ala Thr Cys Pro Pro Ser 435 440 445 Val Pro Glu Pro Pro Lys Lys Lys Gly Arg Thr Lys Lys Lys Lys Gln 450 455 460 Pro Ser Pro Asp Tyr Val Ala Glu Val Tyr Ala Pro His Arg Pro Met 465 470 475 480 Phe Lys Tyr Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Asn 485 490 495 Val Leu Gly Pro Tyr Leu Lys Pro Val Tyr Val Phe Asp Ile Cys Gly 500 505 510 Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu 515 520 525 Asp Pro Lys Phe Thr Ala Gln His Val Glu Glu Leu Asn Arg Leu Leu 530 535 540 Thr Asn Glu Ser His Leu Ser Tyr Phe Asp Ala Arg Ile Lys Pro Ser 545 550 555 560 Ile Leu Lys Ile Glu Ala Tyr Pro Pro Pro Pro Glu Met Leu Asp Pro 565 570 575 Leu Pro Pro Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn 580 585 590 Glu Ala Leu Tyr Asp Glu Val Val Thr Val Ile Asp Ile Leu Thr Leu 595 600 605 His Asn Arg Gly Trp Arg Val Gln Val Leu His Asp Glu Met Asn Ile 610 615 620 Val Phe Pro Glu Trp Lys Thr Leu Cys Ala Asp Tyr Val Thr Lys Asn 625 630 635 640 Ile Leu Ala Lys Glu Lys Ala Asp Arg Glu Lys Asn Glu Val Ile Arg 645 650 655 Ser Ile Ser Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr 660 665 670 Asn Met Asp Thr Thr Arg Ile Ile Phe Glu Gln Asp Leu Ser Glu Ala 675 680 685 Asp Lys Lys Asn Ile Tyr Glu Gly Thr Glu Ile Val Lys His Val Thr 690 695 700 Leu Leu Asn Asp Asp Ser Phe Asn Gly Thr Glu Val Thr Leu Glu Asn 705 710 715 720 Ala Pro Asn Pro Phe Ser Glu Glu Ser Leu Arg Gln Gln Phe Arg Tyr 725 730 735 Ala Asp Asp Pro Glu Gln Glu Glu Pro Glu Ala Glu Glu Asp Gly Glu 740 745 750 Glu Glu Gly Asp Asp Ser Asp Arg Glu Ser Ala Arg Lys Pro Lys Asn 755 760 765 Ala Leu Thr Glu Asp Asp Pro Leu Val Ala Val Asp Leu Glu Val Glu 770 775 780 Ala Thr Leu Ala Thr Gly Pro Tyr Ile Pro Glu Gly Glu Leu Ser Ser 785 790 795 800 Ala His Tyr Ala Arg Ala Asn Glu Thr Arg Phe Lys Pro Met Arg Leu 805 810 815 Leu Glu Ala Thr Pro Glu Ala Leu Thr Val Leu His Leu Glu Ser Leu 820 825 830 Asp Lys Gln Val Ala Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe 835 840 845 Val Leu Gly Trp Ser Arg Ala Phe Phe Ser Glu Trp Cys Asp Ile Leu 850 855 860 Tyr Gly Pro Asp Arg Gly Val His Ile Leu Arg Arg Glu Glu Pro Arg 865 870 875 880 Ser Leu Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Thr Gly Tyr 885 890 895 His Arg Met Lys Ser Arg Gly Ala His Arg Ile Lys Thr Glu Ser Thr 900 905 910 Arg Leu Thr Phe Asp Pro Glu Asn Pro Gly Leu Tyr Trp Ala Cys Asp 915 920 925 Cys Asp Ile Lys Cys Lys Ala Cys Gly Ser Asp Thr Tyr Ser Ser Glu 930 935 940 Thr Ile Phe Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ser Ile Cys 945 950 955 960 Val Asn Glu Gln Cys Arg Thr Val Gly Pro Gly Lys Ile Arg Ser Lys 965 970 975 Gly His Arg Gln Ser Glu Leu Ile Tyr Asp Thr Leu Leu Arg Cys Trp 980 985 990 Arg Arg His Glu Asp Val Gln Phe Gly Ala Gln Ser Asn Ile Pro Glu 995 1000 1005 Leu His Thr Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys 1010 1015 1020 Val Ser Arg Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr 1025 1030 1035 Arg Val Leu Arg Pro Trp Lys Asp Leu Thr Leu Tyr Glu His Gly 1040 1045 1050 Asp Tyr Leu Tyr Pro Tyr Asp Asn Glu His Pro Asn Pro Arg Thr 1055 1060 1065 Thr Gly Asp Val Arg Pro Val Pro Ile Val Gly His Glu Asp Pro 1070 1075 1080 Leu Ala Pro Leu Arg Trp Glu Pro Tyr Ala Phe Leu Ser Glu Glu 1085 1090 1095 Glu Cys Gly Gln Val His Asp Leu Leu Phe Ala Asp Asp Ser Ser 1100 1105 1110 Gln Glu Ala Glu Ser Leu Gly Val 1115 1120 <210> 11 <211> 1159 <212> PRT <213> Fowl adenovirus 9 <400> 11 Met Leu Val Thr Gln Asp Gln Asn Gly Asp Trp Val Trp Ile Leu Ser 1 5 10 15 Arg Thr Ala Val Gln Thr Cys Pro Ala Cys Gly Arg His Trp Val Arg 20 25 30 Asn His Thr Cys Asn Glu Arg Arg Ser Ala Phe Phe Tyr His Thr Val 35 40 45 Gln Lys Phe Gly Cys Asp Leu Trp Gln His Val Arg Phe Ala Cys Pro 50 55 60 Ala Gln Gln Pro His Cys Lys Gln Leu Phe Leu Thr Tyr Asp Ile Glu 65 70 75 80 Thr Tyr Thr Val Phe Glu Asn Lys Gly Lys Arg Met His Pro Phe Met 85 90 95 Leu Cys Phe Met Leu Thr Gly Asp Pro Asp Val Val Arg Ala Ala Thr 100 105 110 Asp Leu Ala Leu Val Asp Pro Glu Val Lys Thr Leu Gln Glu Gly Phe 115 120 125 Tyr Trp Leu Asp Thr Arg Pro Gly Phe Val Ala Arg Arg Phe Arg Ala 130 135 140 Tyr Arg Ser Arg Leu Gln Gln His Phe Ala Arg Asp Leu Val Asp Arg 145 150 155 160 Tyr Cys Arg Ala Asn Gly Asp Tyr Val Ser Lys Leu Met Ser Glu Gly 165 170 175 Lys Tyr Leu Ser Arg Tyr Asp Ile Pro Tyr Glu Leu Phe Asp Lys Pro 180 185 190 Thr Glu Pro Leu Lys Leu Pro Asp Asp Phe Asn Asn Val His Ile Val 195 200 205 Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr 210 215 220 Glu Leu Val Glu Arg Arg Asp Val Phe Pro Gln Ala Cys Arg Cys Asp 225 230 235 240 Arg Phe Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Val Leu 245 250 255 Phe His Leu Pro Asn Pro Asn Tyr Asp Lys Lys Asp Pro Thr Arg Leu 260 265 270 His Arg Trp Ala Arg Gly Val Val Ala Pro Ser Asp Ser Arg Thr Val 275 280 285 Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Phe Thr Ser Gly Ala 290 295 300 Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Glu Leu Ser Lys Gly 305 310 315 320 Gln Cys Pro Tyr Glu Ala Val Asn Glu His Val Ser Ile Gly Gly Tyr 325 330 335 Glu Gln Asp Ser Asp Gly Phe Pro Val Ala Arg Tyr Trp Glu Asp Pro 340 345 350 Ser Val Ile Ala Glu Gln Lys Ala Leu Trp Arg Gln Glu His Pro Gly 355 360 365 Arg Pro Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp 370 375 380 Val Arg Val Thr Gln Lys Leu Ala Leu Thr Leu Tyr Asp Ser Tyr Asp 385 390 395 400 Lys Tyr Phe Lys Asp Glu Leu Gly Met His Gly Asp Phe Asn Ile Phe 405 410 415 Leu Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu 420 425 430 Thr Phe Thr Ala Tyr Val Glu Glu Gln Glu Arg Ala Ser Thr Val Glu 435 440 445 Arg Pro Pro Ser Lys Tyr Lys Arg Lys Val Ala Leu Lys Lys Asn Asp 450 455 460 Ile Lys Gly Asn Pro His Asp Ala Asp Val His Asp Val Glu Arg Ala 465 470 475 480 Ser Ala Asn Lys Asn Thr Lys Lys Arg Lys Lys Arg Leu Pro Ser Pro 485 490 495 Glu Tyr Val Ala Glu Ile Tyr Ala Pro His Arg Pro Met Phe Lys Tyr 500 505 510 Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Ser Val Leu Gly 515 520 525 Pro Tyr Arg His Pro Val Tyr Val Phe Asp Ile Cys Gly Met Tyr Ala 530 535 540 Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu Asp Pro Lys 545 550 555 560 Phe Thr Ala Lys His Val Asp Glu Leu Asn Glu Leu Met Ser Ser Glu 565 570 575 Arg Pro Ile Ser Tyr Phe Asp His Arg Ile Lys Pro Cys Ile Leu Lys 580 585 590 Val Glu Ala Tyr Pro Pro Pro Ala Glu His Leu Asp Thr Leu Pro Pro 595 600 605 Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn Glu Ala Leu 610 615 620 Tyr Asp Glu Val Ile Thr Val Ile Asp Ile Leu Thr Leu His Asn Arg 625 630 635 640 Gly Trp Ala Val Thr Ala Leu His Asp Asp Met Asn Ile Val Phe Pro 645 650 655 Ala Trp Lys Thr Val Cys Ala Glu Tyr Val Ser Lys Asn Ile Ala Ala 660 665 670 Lys Glu Lys Ala Asp Arg Asp Lys Asn Glu Val Met Arg Ser Ile Ser 675 680 685 Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr Asn Met Asp 690 695 700 Thr Thr Arg Ile Leu Phe Glu Gln Asp Leu Thr Glu Asp Asp Arg Arg 705 710 715 720 Gly Ile Tyr Glu Gly Thr Gln Ile Val Arg His Val Thr Leu Leu Asn 725 730 735 His Asp Ser Leu Ala Gly Thr Val Val Cys Pro Glu Ser Thr Pro Asp 740 745 750 Ala Phe Arg His His Gln Leu Arg Gln Tyr Phe Asp Arg Lys Pro Pro 755 760 765 Thr Arg Thr Ala Glu Glu Glu Asn Glu Glu Gln Glu Glu Glu Glu Thr 770 775 780 Glu Glu Ser Glu Gly Glu Ser Thr Ser Lys Leu Glu Asn Ala Leu Thr 785 790 795 800 Ala Arg Glu Ala Ser Leu Ala Glu Val Asp His Gln Leu Gln Glu Ala 805 810 815 Leu Asp Ala Pro Pro Tyr Ile Ala Glu Asp Asp His Ala His Tyr Ala 820 825 830 Thr Ala Asn Glu Thr Val Phe Lys Pro Met Arg Leu Leu Asp Ala Pro 835 840 845 Pro Glu Ala Leu Thr Val Leu His Leu Glu Asn Leu Asp Lys Met Val 850 855 860 Glu Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe Val Leu Gly Trp 865 870 875 880 Ser Arg Ala Phe Phe Ser Glu Trp Cys Glu Ile Leu His Gly Pro Asp 885 890 895 Arg Gly Thr His Leu Leu Gln Arg Asp Pro Gln Thr Leu Tyr Gly Asp 900 905 910 Thr Asp Ser Leu Phe Val Thr Glu Ser Gly Tyr Arg Arg Met Lys Glu 915 920 925 Arg Gly Ala His Arg Ile Lys Gly Pro His Thr Arg Leu Thr Phe Asp 930 935 940 Pro Glu Asn Pro Ala Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys 945 950 955 960 Lys Arg Cys Gly Gly Asp Thr Tyr Ser Ser Glu Ala Ile Phe Leu Ala 965 970 975 Pro Lys Leu Tyr Gly Leu Lys Asp Ala Val Cys Leu Asp Pro Glu Cys 980 985 990 Gly His Val Gly Ser Gly Lys Ile Arg Ser Lys Gly His Arg Gln Ala 995 1000 1005 Glu Leu Ile Tyr Asp Thr Leu Glu Arg Cys Trp Gln Arg His Glu 1010 1015 1020 Asp Gln Ser Tyr Gly Ala Val Ser Ala Ile Pro Glu Leu His Thr 1025 1030 1035 Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val Ser Arg 1040 1045 1050 Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg Val Leu 1055 1060 1065 Arg Pro Trp Lys Asp Leu Thr Gln Tyr Arg His Gly Asp Phe Leu 1070 1075 1080 Tyr Pro Tyr Asp Thr Glu His Pro Asn Pro Arg Thr Ala Asp Glu 1085 1090 1095 Val Arg Arg Val Pro Pro Val Gly His Glu Glu Pro Leu Ala Pro 1100 1105 1110 Leu Arg Leu Leu Ala Ala Ala Ala Ala Ala Arg Ile Ala Pro Glu 1115 1120 1125 Asp Asp Gly Glu Asp Ser Asp Glu Phe Asp Val Pro Asp Arg Ser 1130 1135 1140 Leu Ser Ile Glu Asp Cys Asp Glu Ile Leu Asp Leu Leu Gly Asp 1145 1150 1155 Pro <210> 12 <211> 1159 <212> PRT <213> Fowl adenovirus D <400> 12 Met Leu Val Thr Gln Asp Gln Asn Gly Asp Trp Val Trp Ile Leu Ser 1 5 10 15 Arg Thr Ala Val Gln Thr Cys Pro Ala Cys Gly Arg His Trp Val Arg 20 25 30 Asn His Thr Cys Asn Glu Arg Arg Ser Ala Phe Phe Tyr His Thr Val 35 40 45 Gln Lys Phe Gly Cys Asp Leu Trp Gln His Val Arg Phe Ala Cys Pro 50 55 60 Ala Gln Gln Pro His Cys Lys Gln Leu Phe Leu Thr Tyr Asp Ile Glu 65 70 75 80 Thr Tyr Thr Val Phe Glu Asn Lys Gly Lys Arg Met His Pro Phe Met 85 90 95 Leu Cys Phe Met Leu Thr Gly Asp Pro Asp Val Val Arg Ala Ala Thr 100 105 110 Asp Leu Ala Leu Val Asp Pro Glu Val Lys Thr Leu Gln Glu Gly Phe 115 120 125 Tyr Trp Leu Asp Thr Arg Pro Gly Phe Val Ala Arg Arg Phe Arg Ala 130 135 140 Tyr Arg Ser Arg Leu Gln Gln His Phe Ala Arg Asp Leu Val Asp Arg 145 150 155 160 Tyr Cys Arg Ala Asn Gly Asp Tyr Val Ser Lys Leu Met Ser Glu Gly 165 170 175 Lys Tyr Leu Ser Arg Tyr Asp Ile Pro Tyr Glu Leu Phe Asp Lys Pro 180 185 190 Thr Glu Pro Leu Lys Leu Pro Asp Asp Phe Asn Asn Val His Ile Val 195 200 205 Val Leu Gly His Asn Ile Cys Lys Phe Asp Glu Leu Leu Leu Ala Thr 210 215 220 Glu Leu Val Glu Arg Arg Asp Val Phe Pro Gln Ala Cys Arg Cys Asp 225 230 235 240 Arg Phe Phe Met Pro Arg Val Gly Arg Leu Leu Phe Asn Asp Val Leu 245 250 255 Phe His Leu Pro Asn Pro Asn Tyr Asp Lys Lys Asp Pro Thr Arg Leu 260 265 270 His Arg Trp Ala Arg Gly Val Val Ala Pro Ser Asp Ser Arg Thr Val 275 280 285 Phe Val Arg Phe Met Val Arg Asp Thr Leu Gln Phe Thr Ser Gly Ala 290 295 300 Lys Leu Ser Lys Ala Ala Ala Ala Tyr Ala Leu Glu Leu Ser Lys Gly 305 310 315 320 Gln Cys Pro Tyr Glu Ala Val Asn Glu His Val Ser Ile Gly Gly Tyr 325 330 335 Glu Gln Asp Ser Asp Gly Phe Pro Val Ala Arg Tyr Trp Glu Asp Pro 340 345 350 Ser Val Ile Ala Glu Gln Lys Ala Leu Trp Arg Gln Glu His Pro Gly 355 360 365 Arg Pro Tyr Asp Ile Val Gln Ala Cys Leu Glu Tyr Cys Met Gln Asp 370 375 380 Val Arg Val Thr Gln Lys Leu Ala Leu Thr Leu Tyr Asp Ser Tyr Asp 385 390 395 400 Lys Tyr Phe Lys Asp Glu Leu Gly Met His Gly Asp Phe Asn Ile Phe 405 410 415 Leu Arg Pro Thr Ile Pro Ser Asn Thr His Ala Phe Trp Lys Gln Leu 420 425 430 Thr Phe Thr Ala Tyr Val Glu Glu Gln Glu Arg Ala Ser Thr Val Glu 435 440 445 Arg Pro Pro Ser Lys Tyr Lys Arg Lys Val Ala Leu Lys Lys Asn Asp 450 455 460 Ile Lys Gly Asn Pro His Asp Ala Asp Val His Asp Val Glu Arg Ala 465 470 475 480 Ser Ala Asn Lys Asn Thr Lys Lys Arg Lys Lys Arg Leu Pro Ser Pro 485 490 495 Glu Tyr Val Ala Glu Ile Tyr Ala Pro His Arg Pro Met Phe Lys Tyr 500 505 510 Ile Arg Gln Ala Leu Arg Gly Gly Arg Cys Tyr Pro Ser Val Leu Gly 515 520 525 Pro Tyr Arg His Pro Val Tyr Val Phe Asp Ile Cys Gly Met Tyr Ala 530 535 540 Ser Ala Leu Thr His Pro Met Pro His Gly Met Pro Leu Asp Pro Lys 545 550 555 560 Phe Thr Ala Lys His Val Asp Glu Leu Asn Glu Leu Met Ser Ser Glu 565 570 575 Arg Pro Ile Ser Tyr Phe Asp His Arg Ile Lys Pro Cys Ile Leu Lys 580 585 590 Val Glu Ala Tyr Pro Pro Pro Ala Glu His Leu Asp Thr Leu Pro Pro 595 600 605 Ile Cys Ser Arg Arg Gly Gly Arg Leu Val Trp Thr Asn Glu Ala Leu 610 615 620 Tyr Asp Glu Val Ile Thr Val Ile Asp Ile Leu Thr Leu His Asn Arg 625 630 635 640 Gly Trp Ala Val Thr Ala Leu His Asp Asp Met Asn Ile Val Phe Pro 645 650 655 Ala Trp Lys Thr Val Cys Ala Glu Tyr Val Ser Lys Asn Ile Ala Ala 660 665 670 Lys Glu Lys Ala Asp Arg Asp Lys Asn Glu Val Met Arg Ser Ile Ser 675 680 685 Lys Met Leu Ser Asn Ala Leu Tyr Gly Ala Phe Ala Thr Asn Met Asp 690 695 700 Thr Thr Arg Ile Leu Phe Glu Gln Asp Leu Thr Glu Asp Asp Arg Arg 705 710 715 720 Gly Ile Tyr Glu Gly Thr Gln Ile Val Arg His Val Thr Leu Leu Asn 725 730 735 His Asp Ser Leu Ala Gly Thr Val Val Cys Pro Glu Ser Thr Pro Asp 740 745 750 Ala Phe Arg His His Gln Leu Arg Gln Tyr Phe Asp Arg Lys Pro Pro 755 760 765 Thr Arg Thr Ala Glu Glu Glu Asn Glu Glu Gln Glu Glu Glu Glu Thr 770 775 780 Glu Glu Ser Glu Gly Glu Ser Thr Ser Lys Leu Glu Asn Ala Leu Thr 785 790 795 800 Ala Arg Glu Ala Ser Leu Ala Glu Val Asp His Gln Leu Gln Glu Ala 805 810 815 Leu Asp Ala Pro Pro Tyr Ile Ala Glu Asp Asp His Ala His Tyr Ala 820 825 830 Thr Ala Asn Glu Thr Val Phe Lys Pro Met Arg Leu Leu Asp Ala Pro 835 840 845 Pro Glu Ala Leu Thr Val Leu His Leu Glu Asn Leu Asp Lys Met Val 850 855 860 Glu Asn Lys Arg Tyr Ala Thr Gln Ile Ala Cys Phe Val Leu Gly Trp 865 870 875 880 Ser Arg Ala Phe Phe Ser Glu Trp Cys Glu Ile Leu His Gly Pro Asp 885 890 895 Arg Gly Thr His Leu Leu Gln Arg Asp Pro Gln Thr Leu Tyr Gly Asp 900 905 910 Thr Asp Ser Leu Phe Val Thr Glu Ser Gly Tyr Arg Arg Met Lys Glu 915 920 925 Arg Gly Ala His Arg Ile Lys Gly Pro His Thr Arg Leu Thr Phe Asp 930 935 940 Pro Glu Asn Pro Ala Leu Tyr Trp Ala Cys Asp Cys Asp Ile Lys Cys 945 950 955 960 Lys Arg Cys Gly Gly Asp Thr Tyr Ser Ser Glu Ala Ile Phe Leu Ala 965 970 975 Pro Lys Leu Tyr Gly Leu Lys Asp Ala Val Cys Leu Asp Pro Glu Cys 980 985 990 Gly His Val Gly Ser Gly Lys Ile Arg Ser Lys Gly His Arg Gln Ala 995 1000 1005 Glu Leu Ile Tyr Asp Thr Leu Glu Arg Cys Trp Gln Arg His Glu 1010 1015 1020 Asp Gln Ser Tyr Gly Ala Val Ser Ala Ile Pro Glu Leu His Thr 1025 1030 1035 Arg Arg Thr Ile Phe Lys Thr Thr Leu Leu Asn Lys Val Ser Arg 1040 1045 1050 Tyr Asp Pro Phe Thr Ile His Asn Glu Gln Leu Thr Arg Val Leu 1055 1060 1065 Arg Pro Trp Lys Asp Leu Thr Gln Tyr Arg His Gly Asp Phe Leu 1070 1075 1080 Tyr Pro Tyr Asp Thr Glu His Pro Asn Pro Arg Thr Ala Asp Glu 1085 1090 1095 Val Arg Arg Val Pro Pro Val Gly His Glu Glu Pro Leu Ala Pro 1100 1105 1110 Leu Arg Leu Leu Ala Ala Ala Ala Ala Ala Arg Ile Ala Pro Glu 1115 1120 1125 Asp Asp Gly Glu Asp Ser Asp Glu Phe Asp Val Pro Asp Arg Ser 1130 1135 1140 Leu Ser Ile Glu Asp Cys Asp Glu Ile Leu Asp Leu Leu Gly Asp 1145 1150 1155 Pro <210> 13 <211> 1085 <212> PRT <213> Snake adenovirus 1 <400> 13 Met Glu Ala Ser Thr Thr Thr Val Lys Ala Arg Ser Thr His Tyr Ile 1 5 10 15 Cys Gly His Ala Gly Asp Ser Phe Val Lys Ile Ile Tyr Tyr Lys Asp 20 25 30 Lys Val Lys Ala Val Val Ser Tyr Leu Asn Met Asn Asp Tyr Leu Asn 35 40 45 Thr Tyr Ala Leu Lys Cys Val Ile Pro Glu Lys Ile Thr Lys Asp Phe 50 55 60 Phe Ser Ser Cys Pro Asp Asp Leu Leu Tyr Ser Thr Leu Ala Ser Ile 65 70 75 80 Gln Arg Gly Tyr Ser Pro Lys Lys Lys Glu Glu Leu Gly Gly Lys Trp 85 90 95 Glu Pro Leu Leu Leu Leu Tyr His Arg Gly Glu Glu Tyr Ile Ile Arg 100 105 110 Ala Val Val Pro Gln Arg Arg Cys Glu Asp Cys Gly Lys Gln Phe Val 115 120 125 Ser Ser His Gln Cys Asn Val Arg Arg Arg Glu Phe Tyr His His Ala 130 135 140 Val Leu Pro Asp Thr Lys Thr Trp Trp Lys Pro Ile Lys Phe Ser Pro 145 150 155 160 Ile Gly Ala Leu Ser Asn Ala Lys Arg Leu Phe Ile Ile Tyr Asp Ile 165 170 175 Glu Thr Tyr Thr Phe His Ser Gly Tyr Gly Lys Gln Leu Val Pro Tyr 180 185 190 Leu Leu Val Met Gln Phe Lys Gly Asp Ser Arg Leu Arg Cys Glu Ala 195 200 205 Glu Lys Ile Ala Leu Glu Cys Gly Phe Gln Pro Tyr Arg Gln Cys Phe 210 215 220 Met Met Leu Asn Lys Ala Arg Asp Val Ile Gly His Lys Phe Lys Asp 225 230 235 240 Met Arg Val Gln Leu Gln Lys Arg Ala Ala Ser Asp Ile Trp Ser Arg 245 250 255 Tyr Arg Glu Lys His Asp Ile Leu Ser Glu Glu Gly Val Ser Tyr Ala 260 265 270 Gln Leu Glu Ala Met Ala Lys Asp Asn Leu Leu Lys Thr Asp Ala Glu 275 280 285 Pro Glu Phe Thr Glu Ile Ile Val Val Gly His Asn Ile Thr Gly Phe 290 295 300 Asp Glu Ile Val Leu Ala Ser His Val Leu Glu Gly Leu Pro Lys Asp 305 310 315 320 Glu Glu Leu Gln Met Phe Lys Ile Thr Arg Asn Phe Met Pro Arg Ala 325 330 335 Gly Lys Leu Leu Phe Asn Asp Val Ile Met Ala Leu Pro Asn Ala Ala 340 345 350 Phe Gln Lys Pro Lys Gln Ser Thr Phe Gln Arg Trp Lys Thr Gly Asp 355 360 365 Leu Arg Pro Glu Asp Leu Lys Trp Glu Gly Val Arg Phe Met Val Arg 370 375 380 Asp Thr Val Leu Leu Thr His Ser Ser Leu Arg Asn Ala Ala Gln Ala 385 390 395 400 Tyr Gln Leu Glu Val Ser Lys Gly His Cys Pro Tyr Asp Ala Leu Asn 405 410 415 Gln Tyr Phe Met Val Gly Thr Tyr Leu Cys Asp Glu Asn Met Tyr Pro 420 425 430 Ala Arg Glu Tyr Trp Ser Ser Asp Glu Glu Tyr Leu Glu Asn Lys Pro 435 440 445 Pro Asp Gly Glu Lys Tyr Asp Leu Val Gln Lys Ala Val Asp Tyr Cys 450 455 460 Val Asn Asp Val Lys Val Thr Val Ala Leu Val Lys Lys Leu Cys Ser 465 470 475 480 Gly Tyr Gln Gln Phe Cys Asp Glu Val Leu Lys Leu Asp Cys Thr Phe 485 490 495 Asn Val Phe Gln Arg Pro Thr Ile Ser Ser Thr Thr His Ala Met Phe 500 505 510 Lys Gln Met Phe Tyr Lys Ser Glu Pro Ser Ala Val Gly Lys Phe Leu 515 520 525 Pro Asn Leu Glu Ala Pro Ser Glu Val Met Tyr Glu His Ile Arg Lys 530 535 540 Ser Val Arg Gly Gly Arg Cys Tyr Pro Ser Phe Leu Gly Val Phe Thr 545 550 555 560 Glu Pro His Leu Cys Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu 565 570 575 Ser His Pro Met Pro Tyr Gly Pro Thr Leu Ser Pro Phe Asp Ser Ala 580 585 590 Val Ala Ile Ala Glu Phe Gln Arg Lys Leu Asp Gly Gln Ser Glu Leu 595 600 605 Ser Tyr Phe Asp Pro Asp Ile Phe Pro Met Ile Val Val Ala Asp Ala 610 615 620 Phe Pro Pro Ser Leu His Cys Leu Asp Val Leu Pro Pro Leu Cys Ser 625 630 635 640 Lys Arg Ser Gly Lys Leu Cys Trp Thr Asn Glu Pro Leu Leu Gly Glu 645 650 655 Val Leu Thr Thr Val Asp Leu Ile Met Leu Lys Asn Arg Gly Trp Arg 660 665 670 Val Lys Leu Ile Gln Asn Ala Glu Cys Tyr Ala Val Trp Arg Glu Trp 675 680 685 Arg Pro Leu Cys Arg Glu Tyr Val Ser Ile Asn Ile Ala Ala Lys Glu 690 695 700 Lys Ala Asp Arg Glu Lys Asn Gln Thr Gln Arg Ser Ile Ser Lys Leu 705 710 715 720 Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg Leu Asp Asn Lys 725 730 735 Gln Val Val Phe Met Asp Asp Met Ser Ser Thr Thr Gln Ser Glu Leu 740 745 750 Arg Ser Gly Lys Ala Ser Ile Val Ser Met Thr Ser Val Cys Ser Arg 755 760 765 Ser Leu Pro Gln Lys Asp Thr Ser Phe Trp Glu Arg Tyr Phe Asn Leu 770 775 780 Pro Gln Val Glu Asp Ser Ile Ser Ala Glu Leu Asn Asp Glu Pro Glu 785 790 795 800 Thr Glu Pro Phe Ile Gly Gly Glu Arg Ser His Val Ile Tyr Lys Pro 805 810 815 Ile Thr Phe Leu Ser Ala Glu Cys Asp Asn Leu Leu Leu Ala Thr Val 820 825 830 Gln Ser Asn Ser Asp Trp Val Lys Asn Asp Arg Tyr Ala Thr Gln Val 835 840 845 Ala Ser Phe Val Leu Ala Trp Ser Arg Ala Phe Met Ser Glu Trp Ala 850 855 860 Thr Ile Leu Tyr Gly Glu Asp Ile Gly Val Pro Tyr Glu Gln Arg Lys 865 870 875 880 Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gly Glu 885 890 895 Gly His Arg Leu Met Ile Thr Lys Gly Arg His Lys Leu Lys Ser Ser 900 905 910 Gly Asn Ser Leu Val Tyr Arg Asp Asp Gly Asn Leu Ala Trp Leu Val 915 920 925 Glu Cys Glu Thr Ser Cys Pro Ser Cys Lys Ser Asp Ser Phe Ser Ser 930 935 940 Glu Ser Cys Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr 945 950 955 960 Cys Pro Ser Cys Gly Leu Val Ser Gly Gly Lys Leu Arg Ala Lys Gly 965 970 975 His Ala Lys Ser Cys Ile Thr Tyr Asp Val Leu Lys Ser Cys Phe Leu 980 985 990 Asp His Tyr Leu Leu Glu Arg Pro Thr Glu Gln Tyr Gln Ser Glu Arg 995 1000 1005 Thr Pro Ile Lys Arg Thr Leu Ala Asn Gly Ser Ala Asn Ser Ala 1010 1015 1020 Pro Phe Thr Val Val Glu Lys Gln Leu Ala Arg Val Ile Arg Pro 1025 1030 1035 Trp Asn Asp Pro Thr Met Ala Arg Gly Thr Asp Leu Ser Gln Gly 1040 1045 1050 Phe Leu Leu Phe Pro Tyr Asp Gln Lys Arg Pro Asn Pro Arg Pro 1055 1060 1065 Gln Glu Pro Leu Leu Glu Asn Pro Phe Trp Asp Asp Ser Ser Gln 1070 1075 1080 Thr Ala 1085 <210> 14 <211> 1073 <212> PRT <213> Bovine adenovirus 4 <400> 14 Met Ala Ser Lys Thr Ile Val Lys His Arg Thr Thr His Tyr Ile Thr 1 5 10 15 Gly Tyr Phe Glu Asp Thr Pro Ile Lys Ile Ile Tyr Tyr Lys Asp Phe 20 25 30 Lys Lys Ser Phe Phe Asn Phe Leu Gln Leu Gln Gly Leu Gln Pro Lys 35 40 45 Ala Gln Tyr Lys Ser Phe Leu Lys Pro Glu Asp Ile Leu Gln Tyr Phe 50 55 60 Ser Glu Asp Glu Tyr Pro Ser Val Ile Lys Ile Trp Lys Leu Asn Lys 65 70 75 80 Lys Phe Leu Tyr Tyr Asp Glu Cys Lys Thr Asp Gly Lys Thr Met Ala 85 90 95 Val Glu Leu Val Gln Tyr Lys Asn Ala Trp Phe Leu Val Lys Asp Ile 100 105 110 Lys Lys Gln Gln Lys Cys Glu Asn Cys Gly Val Thr Phe Asn Ser Ile 115 120 125 His Thr Cys Asn Val Lys Arg Arg Asp Phe Tyr Tyr His Phe Ile Asn 130 135 140 His Glu Thr Lys His Trp Trp Glu Gln Ile Lys Phe Asn Pro Val Gly 145 150 155 160 Ala Leu Glu Ser Thr Lys Arg Leu Phe Ile Val Tyr Asp Ile Glu Thr 165 170 175 Tyr Thr Tyr His Ser Thr Tyr Gly Lys Gln Leu Leu Pro Tyr Leu Ile 180 185 190 Val Phe Glu Leu Ile Gly Ser Lys Thr Leu Gln Lys Ile Ala Ala Gln 195 200 205 Ile Ala Tyr Asp Cys Gly Phe Met Met Glu Arg Gly Cys Phe Phe Met 210 215 220 Leu Asn His Arg His Asp Val Ile Gly Asn Ala Phe Lys Lys Phe Arg 225 230 235 240 Ile Met Ile Gln Lys Thr Val Ala Lys Asn Ile Trp Leu Arg Phe Ser 245 250 255 Lys Glu Gln Glu Ile Glu Thr Leu Leu Asn Tyr Asp Glu Ile Leu Lys 260 265 270 Leu Asn Lys Glu Lys Lys Leu Lys Leu Ala Tyr Pro Gln Tyr Val Glu 275 280 285 Ile Phe Val Ile Gly His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu 290 295 300 Ala Ser His Val Leu Glu Gly Ile Arg Asp Gln Glu Asn Leu Ala Met 305 310 315 320 Phe Asn Phe Ser Arg Ser Phe Met Pro Arg Ala Gly Lys Leu Leu Phe 325 330 335 Asn Asp Val Thr Leu Ser Leu Pro Asn Pro Cys Tyr Lys Lys Pro Asp 340 345 350 Lys Thr Thr Phe Glu Arg Trp Lys Lys Gly Ile Leu Leu Pro Glu Asp 355 360 365 Leu Pro Trp Gln Gly Leu Lys Phe Met Val Arg Asp Thr Phe Leu Leu 370 375 380 Thr His Cys Ser Leu Arg Asn Ala Ala Ala Ala Tyr Gln Leu Asn Val 385 390 395 400 Ser Lys Gly His Cys Pro Tyr Asp Ala Ile Asn Asp Tyr Phe Met Leu 405 410 415 Gly Asp Tyr Glu Lys Asp Lys Asn Gly Tyr Pro Val Glu Lys Tyr Trp 420 425 430 Lys Asp Lys Ala Glu Tyr Glu Gln Asn Lys Pro Asn Gly Gln Tyr Asn 435 440 445 Ile Ile Glu Glu Ala Lys Lys Tyr Cys Ile Asp Asp Val Lys Val Thr 450 455 460 Ala Gln Leu Val Ser Lys Leu Ile Asp Gly Tyr Gln Glu Phe Cys Asn 465 470 475 480 Ser Thr Leu Lys Leu Pro Cys Leu Phe Asn Ile Phe Gln Arg Pro Thr 485 490 495 Ile Ser Ser Asn Thr Gln Met Leu Phe Lys Gln Leu His Tyr Arg Glu 500 505 510 Glu Asn Ile Asn Ser Glu Tyr Leu Asn Asn Leu Glu Ala Pro Ser Glu 515 520 525 Lys Met Tyr Ser Phe Val Arg Ala Ser Val Arg Gly Gly Arg Cys Tyr 530 535 540 Pro Thr Phe Leu Gly Ile Tyr Thr Glu Pro Val Tyr Val Tyr Asp Ile 545 550 555 560 Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Tyr Gly Arg 565 570 575 Thr Leu Asn Pro Phe Glu Ala Asn Thr Ser Ile Asp Glu Met Gln Asn 580 585 590 Met Leu Asp Ser Ser Glu Val Leu Ser Tyr Phe Asp Pro Arg Ile Lys 595 600 605 Ala Met Ile Val Val Ala Asp Cys Glu Pro Pro Thr Leu Glu Tyr Leu 610 615 620 Asp Val Leu Pro Pro Leu Cys Ser Lys Lys Ser Gly Lys Leu Cys Trp 625 630 635 640 Thr Asn Glu Pro Leu Ile Asn Glu Thr Val Thr Ser Ile Asp Leu Ile 645 650 655 Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Met Lys Asn Glu Leu 660 665 670 Tyr Ala Val Trp Pro Asn Trp Lys Thr Leu Cys Lys Gln Tyr Val Glu 675 680 685 Ile Asn Ile Ala Ala Lys Glu Arg Ala Asp Lys Glu Lys Asn Lys Thr 690 695 700 Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe 705 710 715 720 Ala Thr Lys Ile Asp Lys Lys Lys Val Ile Phe Ala Glu Asp Ile Glu 725 730 735 Glu Lys Asp Lys Lys Leu Leu Arg Glu Gly Lys Ser Glu Ile Thr Ser 740 745 750 Tyr Thr Thr Val Ile Ser Ser Ser Leu Pro Lys Ser Thr Asp Tyr Asp 755 760 765 Trp Asn Lys Tyr Phe Leu Asn Leu Pro Glu Val Cys Ser Thr Thr Asn 770 775 780 Lys Asn Leu Asn Glu Lys Ser Gly Lys Thr Ala Phe Ile Glu Lys Asn 785 790 795 800 Asp His Val Ile Phe Lys Pro Ile Thr Phe Leu Ser Ala Glu Cys Asn 805 810 815 Asp Leu Val Leu Thr Thr Ile Glu Asp Lys Ala Glu Trp Ile Lys Asn 820 825 830 Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg 835 840 845 Ala Phe Met Ser Glu Trp Ala Asp Ile Leu Tyr Gly Glu Asp Arg Gly 850 855 860 Lys Ser Tyr Ser Glu Arg Asp Leu Lys Ser Leu Tyr Gly Asp Thr Asp 865 870 875 880 Ser Leu Phe Leu Ser Gln Lys Gly His Glu Leu Met Cys Ser Lys Gly 885 890 895 Ala His Arg Leu Lys His Asn Asn Gly Lys Leu Val Phe Asp Glu Asn 900 905 910 Glu Pro Gln Leu Gln Trp Leu Val Glu Cys Glu Thr Val Cys Glu Glu 915 920 925 Cys His Ser Val Ala Phe Ala Thr Glu Ser Cys Phe Leu Ala Pro Lys 930 935 940 Leu Tyr Gly Leu Lys Glu Ile Lys Cys Thr Lys Cys Asn His Ile Gly 945 950 955 960 Ser Gly Lys Leu Arg Ala Lys Gly His Ala Lys Glu Cys Leu Ser Tyr 965 970 975 Asp Val Leu Lys Arg Cys Phe Asn Asp Tyr Tyr Leu Leu Glu Asn Pro 980 985 990 Lys Glu Asn Phe Met Thr Lys Arg Lys Ser Leu Lys Arg Thr Leu Gln 995 1000 1005 Thr Gly Asn Glu Ile Ser Lys Pro Phe Thr Val Val Glu Lys Gln 1010 1015 1020 Leu Leu Arg Ile Leu Arg Pro Trp Lys Asp Met Thr Leu Arg Lys 1025 1030 1035 Gly Ile Gln Leu Ser Glu Gly Tyr Leu Leu Tyr Pro Tyr Asp Lys 1040 1045 1050 Arg His Pro Asn Pro Arg Pro Gln Glu Cys Leu Thr Glu Asn Pro 1055 1060 1065 Phe Trp Asp Asp Thr 1070 <210> 15 <211> 1071 <212> PRT <213> Ovine adenovirus 7 <400> 15 Met Ala Ser Lys Thr Ile Ile Lys Gln Arg Thr Thr Thr Tyr Ile Thr 1 5 10 15 Gly Ile Tyr Glu Asp Thr Tyr Ile Lys Ile Ile Tyr Tyr Lys Asn Phe 20 25 30 Glu Lys Ser Phe Tyr Asn Tyr Phe Ala Ile Gln Gly Leu Lys Leu Asn 35 40 45 Ser Phe Lys Lys Val Glu Asn Val Leu Asp Val Leu Lys Leu Cys Asp 50 55 60 Ser Asn Thr Pro Val Ser Leu Lys Ile Trp Lys Phe Asn Lys Arg Phe 65 70 75 80 Phe Lys Met Thr Glu Glu Ile Leu Asn Gly Asn Leu Leu Pro Ile Glu 85 90 95 Leu Leu Ile Leu Lys Gly Glu Ile Tyr Leu Ile Lys Thr Val Lys Gln 100 105 110 Gln Asn Lys Cys Glu Phe Cys Gly Thr Ile Tyr Ser Asn Ile His Asn 115 120 125 Cys Ser Ser Arg Arg Arg Asp Phe Tyr Tyr His Asn Ile His His Glu 130 135 140 Thr Lys Leu Trp Trp Glu Lys Ile Lys Phe Asn Pro Val Gly Ala Ile 145 150 155 160 Lys Ala Lys Arg Leu Phe Ile Val Tyr Asp Ile Glu Thr Tyr Thr Tyr 165 170 175 His Ser Leu Tyr Gly Lys Gln Leu Thr Pro Tyr Leu Leu Val Phe Lys 180 185 190 Leu Ile Gly Cys Lys Ser Leu Ile Lys Ile Ala Ser Lys Ile Ala Thr 195 200 205 Asp Ile Gly Tyr Glu Val Asn Arg Glu Cys Phe Val Met Leu Asn Lys 210 215 220 Lys Glu Asp Glu Ile Gly Ile Ala Phe Lys Lys Phe Arg Thr Glu Leu 225 230 235 240 Gln Ile Ser Val Ala Lys Lys Tyr Trp Ser Thr Phe Cys Glu Asn His 245 250 255 Gly Leu Glu Ser Asn Leu Ser Tyr Glu Asp Ile Met Val Leu Asn Lys 260 265 270 Glu Lys Lys Leu Lys Gln Cys Glu Pro Arg Tyr Ile Glu Leu Tyr Val 275 280 285 Val Gly His Asn Ile Cys Gly Phe Asp Glu Ile Ile Leu Ala Ser His 290 295 300 Val Leu Glu Gly Ile Asp Ser Glu Glu Leu Ser Met Phe Lys Leu Thr 305 310 315 320 Arg Ser Phe Met Pro Arg Ala Gly Lys Leu Leu Phe Asn Asp Ile Thr 325 330 335 Leu Ser Leu Pro Asn Pro Cys Phe Lys Lys Pro Ser His Thr Thr Tyr 340 345 350 Glu Arg Trp Lys Asn Gly Ile Ile Asn Phe Glu Asp Met Lys Trp Gln 355 360 365 Gly Ile Lys Phe Met Val Arg Asp Thr Phe Leu Leu Thr His Ser Ser 370 375 380 Leu Arg Asp Ala Ala Thr Ala Tyr Gln Leu Ser Val Ser Lys Gly Tyr 385 390 395 400 Cys Pro Tyr Arg Ala Ile Asn Asp Phe Phe Met Leu Gly Glu Tyr Glu 405 410 415 Lys Glu Asn Asn Gly Tyr Pro Val Gln Lys Tyr Trp Asn Ser Phe Glu 420 425 430 Glu Tyr Leu Gln Asn Lys Pro Lys His Asn Gln Lys Tyr Asn Leu Leu 435 440 445 Glu Glu Ala Lys Glu Tyr Cys Ile Asp Asp Val Ile Val Thr Ala Gln 450 455 460 Leu Val Glu Lys Leu Ile Glu Gly Tyr Gln Glu Phe Cys Thr Thr Ser 465 470 475 480 Leu Lys Leu Glu Cys Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser 485 490 495 Ser Asn Thr Gln Ala Leu Phe Lys Gln Ile Phe Tyr Asn Glu Glu Asp 500 505 510 His Pro Ser Glu Phe Leu Arg Asn Leu Glu Ala Pro Ser Glu Lys Met 515 520 525 Tyr Asp Phe Val Arg Met Ser Leu Arg Gly Gly Arg Cys Tyr Pro Ser 530 535 540 Phe Leu Gly Ile Phe Glu Glu Ala Ile Tyr Val Tyr Asp Ile Cys Gly 545 550 555 560 Met Tyr Ala Ser Ala Leu Thr His Pro Leu Pro Tyr Gly Lys Thr Leu 565 570 575 Asn Ala Phe Glu Ala Asn Ala Gln Ile Asp Tyr Phe Gln Glu Leu Leu 580 585 590 Gln Arg Lys Glu Lys Ile Asp Tyr Phe Asp Asn Ser Ile Lys Pro Met 595 600 605 Ile Val Val Ala Asp Cys Glu Pro Pro Ser Leu Asp Tyr Leu Asp Val 610 615 620 Leu Pro Pro Leu Cys Ser Lys Lys Ser Gly Lys Leu Cys Trp Ser Asn 625 630 635 640 Glu Thr Leu Ile Asn Glu Val Leu Thr Ser Ile Asp Leu Ile Thr Leu 645 650 655 His Asn Arg Gly Trp Lys Cys Lys Ile Ile Lys Ser Ser Glu Met Tyr 660 665 670 Ala Val Trp Ser Asp Trp Lys Pro Leu Cys Gln Lys Tyr Val Lys Val 675 680 685 Asn Ile Met Ala Lys Glu Lys Ala Ser Lys Ser Asn Asn Lys Ile Gln 690 695 700 Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala 705 710 715 720 Thr Arg Ile Asp Lys Lys Lys Val Val Phe Ala Glu Asn Ile Glu Glu 725 730 735 Lys Asp Lys Lys Arg Leu Glu Asn Gly Ser Ala Glu Ile Thr Ser Tyr 740 745 750 Thr Thr Val Ile Ser Lys Ser Leu Pro Lys Arg Ser Phe Glu Trp Asn 755 760 765 Gln Tyr Phe Ser Asn Leu Pro Glu Met Pro Pro Lys Asp Ser Lys Asp 770 775 780 Thr Asn Glu Asn Phe Asn Phe Pro Leu Phe Ile Gly Asn Gln Asp His 785 790 795 800 Val Thr Phe Lys Pro Ile Thr Phe Leu Ser Ala Asp Cys Asn Asp Leu 805 810 815 Ile Leu Thr Thr Ile Glu Asp Lys Glu Glu Trp Ile Lys Asn Asn Arg 820 825 830 Tyr Pro Thr Gln Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe 835 840 845 Met Ser Glu Trp Ala Glu Ile Leu Tyr Gly Glu Asp Met Gly Lys Pro 850 855 860 Tyr Ile Glu Arg Glu Ile Lys Ser Ile Tyr Gly Asp Thr Asp Ser Leu 865 870 875 880 Phe Leu Thr Glu Lys Gly His Gln Leu Met Leu Ser Lys Gly Leu His 885 890 895 Arg Leu Lys Lys Tyr Asn Ser Asn Leu Ile Phe Asp Glu Lys His Pro 900 905 910 Cys Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Asn Arg Cys Gly 915 920 925 Ala Glu Ala Phe Ser Ser Glu Thr Cys Ile Leu Ala Pro Lys Leu Tyr 930 935 940 Ala Leu Lys Asp Ile Thr Cys Lys Asn Cys Lys Phe Ile Gly Glu Gly 945 950 955 960 Lys Leu Arg Ala Lys Gly His Ala Lys Asn Cys Leu Asn Tyr Glu Ile 965 970 975 Leu Lys His Cys Phe Thr Asp Tyr Asn Leu Leu Glu Gln Pro Gln Lys 980 985 990 Glu Phe Gln Thr Ser Arg Lys Ser Leu Lys Lys Thr Leu Gln Thr Ala 995 1000 1005 Ser Gly Thr Asp Val Pro Phe Thr Val Val Glu Lys Gln Leu Thr 1010 1015 1020 Arg Ile Leu Arg Pro Trp Lys Asp Gln Thr Met Arg Lys Gly Ile 1025 1030 1035 Gln Trp Lys Lys Gly Tyr Leu Leu Tyr Pro Tyr Asp Lys Arg His 1040 1045 1050 Pro Asn Pro Arg Pro Gln Glu Pro Leu Thr Glu Asn Pro Phe Trp 1055 1060 1065 Glu Asn Phe 1070 <210> 16 <211> 1079 <212> PRT <213> Duck adenovirus A <400> 16 Met Ala Gln Ser Ser Thr Val Ser Arg Leu Arg Ser Thr Lys Tyr Ile 1 5 10 15 Cys Gly Ser Leu Asn Gly Glu Asn Val Lys Ile Thr Tyr Phe Thr Asp 20 25 30 Ile Cys Lys Ala Leu Asn Asn Ile Leu Ala Leu Asn Arg Ile Glu Lys 35 40 45 Lys Ile Phe Thr Ala Pro Asn Leu Gly Asn Ile Ile Lys Ile Phe Pro 50 55 60 Gln Asn Lys Gln Pro Thr His Ile Thr Leu Tyr Lys Leu Glu Lys Gly 65 70 75 80 Leu Ile Lys Thr Glu Glu Ile Phe Ser Gly Gly Asp Ile Glu Pro Leu 85 90 95 Leu Ile Leu Asn His Lys Ser Glu Leu Phe Ile Ile Lys Thr Tyr Val 100 105 110 Thr Gln Glu Lys Cys Gln Thr Cys Gly Thr Leu Tyr Ser Thr Asn His 115 120 125 Asn Cys Asn Val Arg Lys Thr Ala Tyr Phe His His Ile Val Asn Lys 130 135 140 Asp Thr Arg Thr Trp Trp Gln Pro Ile Lys Phe His Pro Val Gly Cys 145 150 155 160 Val Glu Thr Lys Arg Leu Tyr Val Val Tyr Asp Ile Glu Thr Tyr Thr 165 170 175 Tyr His Ser Lys Tyr Gly Lys Gln Leu Val Pro Tyr Leu Leu Val Phe 180 185 190 Gln Leu Phe Gly Glu Glu Thr Leu Ile Asp Leu Ala Lys Ala Glu Ala 195 200 205 Glu Met Val Gly Tyr Thr Ala Tyr Asp Gly Cys Phe Tyr Ile Leu Asn 210 215 220 Lys Asp Pro Glu Val Val Gly Gln Ser Phe Lys Leu Phe Arg Ser Asn 225 230 235 240 Leu Gln Asp Lys Val Thr Asn Leu Ala Trp Glu Arg Phe Cys Glu Asp 245 250 255 Asn Ala Leu Asp Pro Tyr Ser Arg Ile Thr Ala Lys Gln Leu Gln Lys 260 265 270 Leu Asn Lys Ser Gln Lys Leu Asn Lys Thr Ala Glu Pro Gln Phe Tyr 275 280 285 Glu Ile Ile Ile Val Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val 290 295 300 Leu Ala Ser His Ile Leu Asp Asn Val Lys Asp Lys Asp Tyr Phe Val 305 310 315 320 Met Phe Asn Ile Thr Arg Asn Phe Leu Pro Arg Ala Gly Lys Leu Leu 325 330 335 Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Gln Tyr Lys Lys Pro 340 345 350 Ser Arg Gly Thr Phe Asp Arg Trp Gln Asn Gly Met Leu Asp Lys Gln 355 360 365 Asp Leu Lys Trp Gln Gly Val Lys Phe Met Val Arg Asp Thr Tyr Leu 370 375 380 Leu Thr His Thr Ser Leu Arg Asn Ala Ala Thr Ala Tyr Gln Leu Pro 385 390 395 400 Ile Ser Lys Gly Cys Cys Pro Tyr Glu Ala Val Asn Glu Tyr Leu Met 405 410 415 Thr Gly Asn Tyr Glu Gln Glu Thr Asn Gly Tyr Pro Thr Leu Lys Tyr 420 425 430 Trp Asn Asn Ala Asp Glu Tyr His Gln Asn Lys Ile Lys Gly Pro Tyr 435 440 445 Asp Ile Leu Lys Glu Ala Leu Ile Tyr Cys Ile Ala Asp Val Lys Val 450 455 460 Thr Ser Gln Leu Thr Arg Lys Leu Ile Glu Gly Tyr Gln Ser Phe Cys 465 470 475 480 Asn Asp Gln Ile Lys Leu Thr Cys Gln Phe His Ile Phe Gln Arg Pro 485 490 495 Thr Ile Ser Ser Asn Thr His Ala Leu Phe Lys Gln Ile Leu Tyr Arg 500 505 510 Ala Glu Lys Gly Gln Thr Glu His Leu Pro Gly Leu Gln Ala Pro Ser 515 520 525 Glu Lys Met Tyr Asp His Ile Arg Lys Ser Val Arg Gly Gly Arg Cys 530 535 540 Tyr Pro Ser Tyr Leu Gly Val Tyr Glu Gly Pro Ile Tyr Val Tyr Asp 545 550 555 560 Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Phe Gly 565 570 575 Arg Thr Glu Asp Pro Leu Thr Ala Ser Ile Ser Ile Lys Thr Phe Gln 580 585 590 Asp Lys Leu Asp Ser Pro Ala Lys Leu Ser Tyr Phe Gly Glu Ser Ile 595 600 605 Lys Pro Met Ile Val Tyr Ala Asp Cys Tyr Pro Pro Pro Leu Glu His 610 615 620 Val Asp Val Leu Pro Pro Leu Cys Ser Arg Lys Ser Gly Arg Leu Cys 625 630 635 640 Trp Thr Asn Glu Pro Leu Leu Gly Glu Val Val Thr Thr Ile Asp Leu 645 650 655 Ile Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Leu Thr Ser Glu 660 665 670 Gln Leu Tyr Ala Val Trp Pro Glu Trp Lys Cys Ile Thr Lys Glu Tyr 675 680 685 Val Ser Ile Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Asp Lys Asn 690 695 700 Met Thr Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly 705 710 715 720 Ser Phe Ala Thr Arg Leu Asp Asn Lys Lys Val Val Phe Ala Asn Ser 725 730 735 Met Glu Lys Gly Asp Met Glu Arg Ile Ala Asn Gly Lys Ala Thr Ile 740 745 750 Thr Ala Gln Thr Thr Val Ile Asn Thr Cys Leu Pro Lys Lys Asp Thr 755 760 765 Thr Ser Trp Glu Arg Phe Phe Ser Asn Leu Pro Gln Thr Thr Ala Leu 770 775 780 Pro Val Ala Pro Ser Thr Glu Asn Glu Gly Asn Asp Ile Asn Pro Lys 785 790 795 800 Ser Phe Ile Glu Gly Ala Gly His Val Thr Phe Lys Pro Ile Thr His 805 810 815 Leu Thr Ala Ala Cys Asp Asp Leu Ile Leu Ser Ile Ile Glu Glu Arg 820 825 830 Ser Glu Trp Ile Glu Asn Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe 835 840 845 Val Leu Ala Trp Thr Arg Ala Phe Thr Ser Glu Trp Ala Ser Phe Leu 850 855 860 Phe Glu Asp Asp Trp Gly Ser Asn Ile Glu Asn Arg Ser Leu Lys Val 865 870 875 880 Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gln His Gly His Glu 885 890 895 Leu Met Ile Thr Lys Gly Lys His Arg Ile Lys Gly Tyr Gly Thr Ala 900 905 910 Leu Thr Phe Asp Pro His Asn Pro Asn Leu Thr Trp Leu Val Glu Cys 915 920 925 Glu Thr Val Cys Pro Leu Cys Lys Lys Ile Ala Tyr Ser Thr Glu Ser 930 935 940 Val Tyr Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ile Tyr Cys Glu 945 950 955 960 His Cys Asp Val Tyr Ser Ala Gly Lys Leu Arg Ala Lys Gly His Ala 965 970 975 Lys Asp Cys Ile Asn Tyr Glu Thr Leu Lys Lys Cys Phe Ile Asp His 980 985 990 Asp Leu Leu Thr Gly Arg Asp Leu Gln Tyr Lys Thr Gln Arg Lys Met 995 1000 1005 Leu Lys Arg Thr Leu Thr Ala Gly Asn Thr Thr Asn Arg Pro Phe 1010 1015 1020 Thr Val Val Glu Lys Gln Leu Thr Arg Thr Leu Arg Pro Trp Ala 1025 1030 1035 Asp Met Thr Met Trp Ala Val Thr Gln Ser Asn Asn Gly Tyr Leu 1040 1045 1050 Leu Phe Pro Tyr Asp Lys Lys His Pro Asn Pro Arg Gln Gln Glu 1055 1060 1065 Leu Leu Thr Glu Asn Pro Phe Trp Glu Ser Thr 1070 1075 <210> 17 <211> 1079 <212> PRT <213> Duck adenovirus 1 <400> 17 Met Ala Gln Ser Ser Thr Val Ser Arg Leu Arg Ser Thr Lys Tyr Ile 1 5 10 15 Cys Gly Ser Leu Asn Gly Glu Asn Val Lys Ile Thr Tyr Phe Thr Asp 20 25 30 Ile Cys Lys Ala Leu Asn Asn Ile Leu Ala Leu Asn Arg Ile Glu Lys 35 40 45 Lys Ile Phe Thr Ala Pro Asn Leu Gly Asn Ile Ile Lys Ile Phe Pro 50 55 60 Gln Asn Lys Gln Pro Thr His Ile Thr Leu Tyr Lys Leu Glu Lys Gly 65 70 75 80 Leu Ile Lys Thr Glu Glu Ile Phe Ser Gly Gly Asp Ile Glu Pro Leu 85 90 95 Leu Ile Leu Asn His Lys Ser Glu Leu Phe Ile Ile Lys Thr Tyr Val 100 105 110 Thr Gln Glu Lys Cys Gln Thr Cys Gly Thr Leu Tyr Ser Thr Asn His 115 120 125 Asn Cys Asn Val Arg Lys Thr Ala Tyr Phe His His Ile Val Asn Lys 130 135 140 Asp Thr Arg Thr Trp Trp Gln Pro Ile Lys Phe His Pro Val Gly Cys 145 150 155 160 Val Glu Thr Lys Arg Leu Tyr Val Val Tyr Asp Ile Glu Thr Tyr Thr 165 170 175 Tyr His Ser Lys Tyr Gly Lys Gln Leu Val Pro Tyr Leu Leu Val Phe 180 185 190 Gln Leu Phe Gly Glu Glu Thr Leu Ile Asp Leu Ala Lys Ala Glu Ala 195 200 205 Glu Met Val Gly Tyr Thr Ala Tyr Asp Gly Cys Phe Tyr Ile Leu Asn 210 215 220 Lys Asp Pro Glu Val Val Gly Gln Ser Phe Lys Leu Phe Arg Ser Asn 225 230 235 240 Leu Gln Asp Lys Val Thr Asn Leu Ala Trp Glu Arg Phe Cys Glu Asp 245 250 255 Asn Ala Leu Asp Pro Tyr Ser Arg Ile Thr Ala Lys Gln Leu Gln Lys 260 265 270 Leu Asn Lys Ser Gln Lys Leu Asn Lys Thr Ala Glu Pro Gln Phe Tyr 275 280 285 Glu Ile Ile Ile Val Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val 290 295 300 Leu Ala Ser His Ile Leu Asp Asn Val Lys Asp Lys Asp Tyr Phe Val 305 310 315 320 Met Phe Asn Ile Thr Arg Asn Phe Leu Pro Arg Ala Gly Lys Leu Leu 325 330 335 Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Gln Tyr Lys Lys Pro 340 345 350 Ser Arg Gly Thr Phe Asp Arg Trp Gln Asn Gly Met Leu Asp Lys Gln 355 360 365 Asp Leu Lys Trp Gln Gly Val Lys Phe Met Val Arg Asp Thr Tyr Leu 370 375 380 Leu Thr His Thr Ser Leu Arg Asn Ala Ala Thr Ala Tyr Gln Leu Pro 385 390 395 400 Ile Ser Lys Gly Cys Cys Pro Tyr Glu Ala Val Asn Glu Tyr Leu Met 405 410 415 Thr Gly Asn Tyr Glu Gln Glu Thr Asn Gly Tyr Pro Thr Leu Lys Tyr 420 425 430 Trp Asn Asn Ala Asp Glu Tyr His Gln Asn Lys Ile Lys Gly Pro Tyr 435 440 445 Asp Ile Leu Lys Glu Ala Leu Ile Tyr Cys Ile Ala Asp Val Lys Val 450 455 460 Thr Ser Gln Leu Thr Arg Lys Leu Ile Glu Gly Tyr Gln Ser Phe Cys 465 470 475 480 Asn Asp Gln Ile Lys Leu Thr Cys Gln Phe His Ile Phe Gln Arg Pro 485 490 495 Thr Ile Ser Ser Asn Thr His Ala Leu Phe Lys Gln Ile Leu Tyr Arg 500 505 510 Ala Glu Lys Gly Gln Thr Glu His Leu Pro Gly Leu Gln Ala Pro Ser 515 520 525 Glu Lys Met Tyr Asp His Ile Arg Lys Ser Val Arg Gly Gly Arg Cys 530 535 540 Tyr Pro Ser Tyr Leu Gly Val Tyr Glu Gly Pro Ile Tyr Val Tyr Asp 545 550 555 560 Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Phe Gly 565 570 575 Arg Thr Glu Asp Pro Leu Thr Ala Ser Ile Ser Ile Lys Thr Phe Gln 580 585 590 Asp Lys Leu Asp Ser Pro Ala Lys Leu Ser Tyr Phe Gly Glu Ser Ile 595 600 605 Lys Pro Met Ile Val Tyr Ala Asp Cys Tyr Pro Pro Pro Leu Glu His 610 615 620 Val Asp Val Leu Pro Pro Leu Cys Ser Arg Lys Ser Gly Arg Leu Cys 625 630 635 640 Trp Thr Asn Glu Pro Leu Leu Gly Glu Val Val Thr Thr Ile Asp Leu 645 650 655 Ile Thr Leu His Asn Arg Gly Trp Lys Cys Lys Ile Leu Thr Ser Glu 660 665 670 Gln Leu Tyr Ala Val Trp Pro Glu Trp Lys Cys Ile Thr Lys Glu Tyr 675 680 685 Val Ser Ile Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Asp Lys Asn 690 695 700 Met Thr Gln Arg Ser Ile Ser Lys Leu Leu Ser Asn Ala Leu Tyr Gly 705 710 715 720 Ser Phe Ala Thr Arg Leu Asp Asn Lys Lys Val Val Phe Ala Asn Ser 725 730 735 Met Glu Lys Gly Asp Met Glu Arg Ile Ala Asn Gly Lys Ala Thr Ile 740 745 750 Thr Ala Gln Thr Thr Val Ile Asn Thr Cys Leu Pro Lys Lys Asp Thr 755 760 765 Thr Ser Trp Glu Arg Phe Phe Ser Asn Leu Pro Gln Thr Thr Ala Leu 770 775 780 Pro Val Ala Pro Ser Thr Glu Asn Glu Gly Asn Asp Ile Asn Pro Lys 785 790 795 800 Ser Phe Ile Glu Gly Ala Gly His Val Thr Phe Lys Pro Ile Thr His 805 810 815 Leu Thr Ala Ala Cys Asp Asp Leu Ile Leu Ser Ile Ile Glu Glu Arg 820 825 830 Ser Glu Trp Ile Glu Asn Asn Arg Tyr Pro Thr Gln Ile Ala Ser Phe 835 840 845 Val Leu Ala Trp Thr Arg Ala Phe Thr Ser Glu Trp Ala Ser Phe Leu 850 855 860 Phe Glu Asp Asp Trp Gly Ser Asn Ile Glu Asn Arg Ser Leu Lys Val 865 870 875 880 Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Gln His Gly His Glu 885 890 895 Leu Met Ile Thr Lys Gly Lys His Arg Ile Lys Gly Tyr Gly Thr Ala 900 905 910 Leu Thr Phe Asp Pro His Asn Pro Asn Leu Thr Trp Leu Val Glu Cys 915 920 925 Glu Thr Val Cys Pro Leu Cys Lys Lys Ile Ala Tyr Ser Thr Glu Ser 930 935 940 Val Tyr Leu Ala Pro Lys Leu Tyr Gly Leu Lys Asn Ile Tyr Cys Glu 945 950 955 960 His Cys Asp Val Tyr Ser Ala Gly Lys Leu Arg Ala Lys Gly His Ala 965 970 975 Lys Asp Cys Ile Asn Tyr Glu Thr Leu Lys Lys Cys Phe Ile Asp His 980 985 990 Asp Leu Leu Thr Gly Arg Asp Leu Gln Tyr Lys Thr Gln Arg Lys Met 995 1000 1005 Leu Lys Arg Thr Leu Thr Ala Gly Asn Thr Thr Asn Arg Pro Phe 1010 1015 1020 Thr Val Val Glu Lys Gln Leu Thr Arg Thr Leu Arg Pro Trp Ala 1025 1030 1035 Asp Met Thr Met Trp Ala Val Thr Gln Ser Asn Asn Gly Tyr Leu 1040 1045 1050 Leu Phe Pro Tyr Asp Lys Lys His Pro Asn Pro Arg Gln Gln Glu 1055 1060 1065 Leu Leu Thr Glu Asn Pro Phe Trp Glu Ser Thr 1070 1075 <210> 18 <211> 1202 <212> PRT <213> Murine adenovirus 3 <400> 18 Met Ala Gln Ile Ile Ser Ser Val Gly Thr Ser Ser Leu His Pro Glu 1 5 10 15 Ser Thr Asn Thr Asn Leu Asp Ser Ser Ser Leu Thr Gly Ser Asn Gln 20 25 30 Ile Ala Ala Gly Thr Pro Ser Asn Ala Glu Ser Gln Pro Ser Ser Arg 35 40 45 Thr Pro Ser Arg Gly Arg Pro Arg Lys Ala Thr Val Ser Pro Leu Lys 50 55 60 Lys Arg Lys Ser Lys Val Ile Ala Lys Ser His Lys Thr Leu Lys Ala 65 70 75 80 Pro Cys Pro Asn Gly Gln Tyr Met Ala Val Gly Tyr Phe Thr Ser Phe 85 90 95 Leu Gln Pro Phe Thr Asn Leu Leu Cys Leu Gln Asp Gly Glu Ser Phe 100 105 110 Pro His Pro Asn Leu Cys Asp Leu Phe Lys Thr Ser Asp Ala Ser His 115 120 125 Lys Lys Pro Thr Val Arg Gln Leu Thr Asn Ala Leu Gln Lys Glu Glu 130 135 140 Trp Pro Ala Pro Val Thr His Val Trp Phe Asp Gly Lys Tyr Leu Arg 145 150 155 160 Lys Ser Asn Trp Pro Asn Leu Lys Ser Pro Ala Gly Cys Tyr Pro Ser 165 170 175 Glu Pro Lys Gln Gly Ser Leu Glu Glu Lys Arg Trp Ser Trp Gln Lys 180 185 190 Thr Arg Pro His Leu Thr Phe Leu Glu Ile Gln Lys Gly Thr Gly Arg 195 200 205 Gly Pro Glu Asn His Gln Met Gly Leu Tyr Leu Val Asp Tyr Ile Tyr 210 215 220 Pro Cys Glu Arg Cys Glu Asp Cys Gly Thr Ile Phe Arg Phe Lys His 225 230 235 240 Thr Cys Asn Ala Arg Arg Arg Ser Tyr Phe Phe His Asn Leu Gln Pro 245 250 255 Leu Ser Arg Arg Trp Trp Ser Lys Ile Ser Phe Ser Pro Leu Gly Ser 260 265 270 Ile Pro Ser Thr Gln Arg Leu Phe Ile Ile Tyr Asp Leu Glu Thr Tyr 275 280 285 Cys Trp His Gly Ser Cys Gly Lys Gln Leu Val Pro Phe Met Ile Val 290 295 300 Met Gln Phe Trp Gly Glu Ser Thr Leu Cys Ser Thr Ala Tyr Lys Val 305 310 315 320 Ala Lys Asn Thr Gly Tyr Ile Asn Tyr Gly Ser Asp Pro Tyr Leu Phe 325 330 335 Tyr Ala Ile Asn Pro Gln Lys Gln Ala Ile Gly Arg Gln Phe Arg Asn 340 345 350 Phe Arg Asp Arg Leu Gln Glu Thr Phe Ala Arg Glu Phe Trp Glu Arg 355 360 365 Asn Met Thr Pro Glu Met Lys Lys Tyr Ile Ala Ser Leu Pro Leu Gly 370 375 380 Leu Leu Asp Leu Thr Pro Gln Lys Leu Pro Glu Ala Pro Gln Leu Thr 385 390 395 400 Pro Lys Pro Gln Phe Ile Glu Val Tyr Val Val Gly His Asn Ile Asn 405 410 415 Gly Phe Asp Glu Ile Val Val Ala Ala Gln Val Leu Asn Asn Arg Ile 420 425 430 Asn Phe Pro Pro Pro Ile Glu Val His Arg His Phe Met Pro Arg Asn 435 440 445 Gly Arg Ile Leu Phe Asn Asp Ile Thr Phe Ser Leu Pro Asn Pro Leu 450 455 460 Tyr Glu Ala Arg Glu Asp Phe Gly Ser Trp Glu Glu Gly Arg Leu Ser 465 470 475 480 Ile Ser Asp Ser Lys Ile Gln Tyr Val Lys Phe Met Val Arg Asp Thr 485 490 495 Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala Glu Ala Tyr Ala 500 505 510 Leu Pro Val Glu Lys Gly Leu Cys Pro Tyr Ala Ala Ile Asn Asp Phe 515 520 525 Tyr Met Thr Gly Lys Tyr Glu Ser Asp Ser Ser Asp Gly Phe Pro Ser 530 535 540 Arg Lys Tyr Trp Ser Ser Asp Glu Glu Phe Asn Glu Ala Phe Ala Gln 545 550 555 560 Trp Arg Thr Glu Gln Met His Asp Arg Thr Ser Phe Glu Pro Leu Gln 565 570 575 Tyr Asn Leu Ile Glu Gln Thr Leu Lys Tyr Cys Ile Lys Asp Val Gln 580 585 590 Val Thr Thr Lys Leu Val Cys Lys Leu Phe Ser Ser Tyr Lys Lys Phe 595 600 605 Ile Gln Thr Glu Val Gln Leu Pro Lys Cys Ser Phe Asn Ile Phe Gln 610 615 620 Arg Pro Thr Ile Ser Ala Asn Ser His Ala Ile Phe Lys Gln Thr Leu 625 630 635 640 Tyr Thr Glu Gln Arg Pro Gly Lys Pro Asn Phe His Asn Cys Leu Leu 645 650 655 Ala Pro Ser Arg Glu Met Tyr Asp Phe Val Arg Gln Ser Ile Arg Gly 660 665 670 Gly Arg Cys Tyr Pro Thr Tyr Leu Gly Glu Val Thr Glu Pro Ile Tyr 675 680 685 Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met 690 695 700 Pro Thr Gly Trp Pro Leu Asp Pro Lys Ala Arg Ala Glu Ala Leu Glu 705 710 715 720 Asn Trp Gln Ile Lys Leu Ser Gln Arg Glu Lys Leu Ser Tyr Phe Asp 725 730 735 Ser His Leu Leu His Gly Ile Val Leu Ile Asp Ala Asp Pro Pro Ser 740 745 750 Glu Lys Asp Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly 755 760 765 Arg Leu Cys Trp Thr Asn Glu Thr Leu Arg Gly Glu Val Ala Thr Thr 770 775 780 Ile Asp Val Ile Thr Leu His Asn Arg Gly Trp Lys Val Lys Ile Leu 785 790 795 800 Pro Glu Asp Arg Thr Thr Leu Phe Pro Gln Met Lys Cys Leu Val Arg 805 810 815 Thr Tyr Val Thr Ile Asn Ile Ala Ala Lys Glu Arg Ala Asp Lys Gln 820 825 830 Lys Asn Met Val Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu 835 840 845 Tyr Gly Ser Phe Ala Thr Arg Gln Asp Asn Lys Cys Thr Leu Phe Thr 850 855 860 Ser Gln Leu Gln Ala Gly Val Ile Lys Asp Ile Cys Glu Gly Glu Gln 865 870 875 880 Lys Val Lys Ala Ile His Val Val Glu Thr Asp Asn Leu Ser Ala Glu 885 890 895 Ile Leu Thr Pro Phe Lys Ala Leu Tyr Gln Pro Ala His Lys Gln Ala 900 905 910 Arg Gln Lys Glu Pro Ser Thr Pro Met Met Ala Glu Gly Arg Pro Ser 915 920 925 Ser Phe Tyr Ser His Glu Lys Thr Leu Asn His Ala Leu Ser Asn Tyr 930 935 940 Lys Pro Ile Thr Phe Leu Glu Ala Glu Ala Asp Asp Leu Thr Leu Val 945 950 955 960 Thr Leu Glu Arg Ser Ser Pro Leu Val Gly Asn Asp Arg Tyr Ala Ser 965 970 975 His Leu Ala Ser Phe Val Leu Ala Trp Thr Arg Gly Phe Met Ser Glu 980 985 990 Trp Ser Glu Ile Leu Tyr Glu Ser Asp Arg Gly Ile Ala Leu Glu Arg 995 1000 1005 Arg Leu Asn Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val 1010 1015 1020 Thr Glu His Gly Arg Ile Leu Met Glu Thr Arg Gly Gln His Arg 1025 1030 1035 Leu Lys Lys Asn Gly Gly Lys Leu Val Phe Asn Pro Asn Ser Pro 1040 1045 1050 Gln Leu Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Lys Arg Cys 1055 1060 1065 Asn Ser Asp Ala Phe Ser Pro Arg Thr Ile Phe Leu Ala Pro Lys 1070 1075 1080 Leu Tyr Ala Leu Gln Lys Leu Ile Cys Gln Asn Cys Gly Glu Glu 1085 1090 1095 Gly Pro Gly Lys Leu Arg Ala Lys Gly His Ala Val Thr Ser Leu 1100 1105 1110 Ser Tyr Asp Met Leu His Ala Cys Phe Glu Ala Tyr Arg Leu Lys 1115 1120 1125 Asp Asn Glu Pro Asn Phe Tyr Thr Ser Arg Gln Ser Leu Arg Arg 1130 1135 1140 Thr Leu Ile Ser Met Asn Gln Gln Glu Ser Ala Phe Thr Val Thr 1145 1150 1155 Glu Thr Thr Leu Thr Arg Ser Leu Arg Pro Trp Gln Ser Pro Thr 1160 1165 1170 Leu Ala Ser Leu Gly Asp Gly Arg Leu Val Pro Tyr Ser Ser Ala 1175 1180 1185 Arg Pro Asn Pro Arg Asn Arg Glu Thr Thr Trp Ile Ala Ile 1190 1195 1200 <210> 19 <211> 1214 <212> PRT <213> Murine adenovirus A <400> 19 Met Ala Gln Ile Val Pro Ala Phe Gly Ser Ser Gly Ile His Arg Lys 1 5 10 15 Ser Thr Asp Thr Asn Leu Asn Pro Ser Ser Ile Thr Gly Gly Asp Ser 20 25 30 Ser Ser Ser Thr Thr Thr Pro Asp Ala Asp Ala Gln Ser Ser Ser Arg 35 40 45 Thr Pro Ala Arg Gly Arg Pro Arg Lys Lys Ala Thr Val Ser Ser Pro 50 55 60 Lys Gln Lys Gln Gln Ser Lys Val Leu Gln Lys Ala His Lys Thr Leu 65 70 75 80 Arg Ala Ala Cys Pro Arg Gly Asp His Met Val Ile Gly Tyr Phe Thr 85 90 95 Ser Tyr Val Val Pro Phe Thr Asn Leu Leu Cys Leu Gln Arg Cys Gly 100 105 110 Pro Phe Pro His Pro Phe Leu Leu Asp Ala Phe Lys Ala Ala Asp Ile 115 120 125 Gly His Lys Ser Ile Ser Val Thr Ser Leu Thr Arg Leu Leu Gln Lys 130 135 140 Glu Glu Trp Pro Ala Pro Val Asn Tyr Val Trp Tyr Asp Gly Leu Tyr 145 150 155 160 Ile Arg Gln Ser Lys Trp Pro Gly Leu Lys Gly His Ala Gly Arg Tyr 165 170 175 Pro Gln Val Asp Lys Asp Ala Ser Tyr Glu Glu Lys Arg Trp Cys Trp 180 185 190 Gln Asn Tyr Arg Pro Glu Leu Thr Phe Leu His Ile Gln Lys Gly Leu 195 200 205 Gly Thr Lys Gly Ser Asn Tyr His Lys Ile Gly Leu Tyr Leu Val Asp 210 215 220 Thr Met His Pro Cys Gln Arg Cys Glu Asp Cys Gly Ser Phe Phe Arg 225 230 235 240 Phe Lys His Thr Cys Asn Ala Arg Arg Arg Ser Phe Phe Phe His Asn 245 250 255 Leu Lys Pro Leu Ser Arg Gln Trp Trp Thr Lys Ile Ser Phe Thr Pro 260 265 270 Leu Gly Ser Ile Pro Thr Thr Lys Arg Leu Phe Ile Ile Tyr Asp Leu 275 280 285 Glu Thr Tyr Cys Trp His Gly Ser Cys Gly Lys Gln Leu Val Pro Phe 290 295 300 Met Leu Val Met Glu Leu Tyr Gly Asp Met Phe Leu Cys Ala Lys Ala 305 310 315 320 His Ser Ile Ala Lys Gln Met Gly Tyr Ser Glu His His Leu Arg Pro 325 330 335 Tyr Ile Leu Trp Ser Ile Asn Pro Gln Lys Glu Ala Ile Gly Arg Gln 340 345 350 Phe Arg Arg Phe Arg Asp Arg Leu Gln Glu Ala Phe Ala Glu Glu Leu 355 360 365 Trp Gln Asn Asn Ile Tyr Pro Glu Leu Gln Thr Tyr Ile Asp Ser Leu 370 375 380 Pro Leu Gly Leu Leu Asp Leu Thr Pro Glu Arg Leu Glu Gln Glu Ala 385 390 395 400 Pro Pro Leu Lys Asn Thr Pro Lys Phe Ile Glu Val Tyr Val Val Gly 405 410 415 His Asn Ile Asn Gly Phe Asp Glu Ile Val Val Ala Ala Gln Val Leu 420 425 430 Asn Asn Arg Val Asn Phe Pro Pro Pro Leu Arg Val His Arg His Phe 435 440 445 Met Pro Arg Asn Gly Arg Ile Leu Phe Asn Asp Ile Thr Phe Ser Leu 450 455 460 Pro Asn Pro Arg Tyr Lys Lys Arg Thr Asp Phe Glu Gln Trp Glu Gln 465 470 475 480 Gly Cys Leu Thr Thr Ser Asp Ser Lys Ile Gln Tyr Val Lys Phe Met 485 490 495 Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala 500 505 510 Glu Ala Tyr Ser Leu Pro Leu Glu Lys Gly Val Cys Pro Tyr Ala Ala 515 520 525 Val Asn Asp Phe Tyr Met Thr Gly Arg Tyr Asp Thr Ile Asn Ile Phe 530 535 540 Asp Gly Phe Pro His Arg Lys Tyr Trp Asn Ser Glu Ala Glu Tyr Glu 545 550 555 560 Glu Gly Leu Gln Glu Trp Lys Lys Glu Lys Glu Glu Leu Arg Lys Arg 565 570 575 Cys Pro Asp Arg Val Cys Pro Ile Lys Tyr Asn Leu Ile Glu His Thr 580 585 590 Leu Lys Tyr Cys Ile Gln Asp Val Thr Val Thr Thr Lys Leu Val Cys 595 600 605 Lys Leu Leu Asp Ser Tyr His His Phe Ile Gln Asn Ala Val Gly Leu 610 615 620 Pro Lys Cys Leu Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser Ala Asn 625 630 635 640 Ser His Ala Ile Phe Lys Gln Thr Leu Tyr Ser Glu Leu Arg Pro Glu 645 650 655 Lys Pro Asn Phe Asp Asp Val Leu Leu Ala Pro Ser Arg Glu Met Tyr 660 665 670 Asp Phe Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Val 675 680 685 Leu Gly Glu Leu Lys Glu Pro Ile Tyr Val Tyr Asp Ile Cys Gly Met 690 695 700 Tyr Ala Ser Ala Leu Thr His Pro Met Pro Ser Gly Trp Pro Leu Glu 705 710 715 720 Pro Lys Ala Arg Ala Glu Ala Leu Ala Asp Trp Thr Lys His Leu Ser 725 730 735 Asn Ser Ala Pro Ile Ser Tyr Phe Asn Thr Cys Leu Leu His Gly Ile 740 745 750 Val Leu Ile Asp Ala Asp Pro Pro Cys Glu Thr Gln Leu Asp Val Leu 755 760 765 Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu 770 775 780 Pro Leu Arg Gly Glu Ile Thr Thr Thr Ile Asp Val Ile Thr Leu His 785 790 795 800 Asn Arg Gly Trp Lys Val Asn Ile Leu Pro Glu Ala Leu Thr Thr Leu 805 810 815 Phe Pro His Met Lys Cys Leu Val Arg Lys Tyr Val Thr Ile Asn Ile 820 825 830 Thr Ala Lys Glu Lys Ala Asp Arg Gln Lys Asn Met Val Met Arg Ser 835 840 845 Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Arg 850 855 860 Gln Asp Asn Lys Ser Thr Val Phe Ala Ser Gln Leu Tyr Pro Gly Thr 865 870 875 880 Ile Lys Glu Ile Cys Thr Gly Arg Gln Lys Ile Lys Ala Leu His Val 885 890 895 Val Glu Thr Asp Asn Leu Cys Ala Glu Ile Leu Thr Glu Phe Lys Thr 900 905 910 Ile Tyr Gln Pro Ser Cys Glu Asn Thr Arg Pro Pro His Val Ala Asp 915 920 925 Ser Ala Glu Leu Ser Pro Arg Gly Ser His Pro Ala Pro Phe Tyr Arg 930 935 940 Glu Gln Gln Val Val Asp His Ala Leu Phe Asn Phe Lys Pro Ile Lys 945 950 955 960 Phe Leu Asp Ala Glu Ala Asp Asp Leu Thr Leu Val Thr Leu Glu His 965 970 975 Ser Asn Pro Leu Val Asp Asn Asp Arg Tyr Ala Ser His Leu Ala Ser 980 985 990 Phe Val Leu Ala Trp Thr Arg Gly Phe Met Ser Glu Trp Ser Asp Ile 995 1000 1005 Leu Tyr Glu Ser Asp Arg Gly Leu Gln Leu Glu Lys Arg Leu Ile 1010 1015 1020 Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala 1025 1030 1035 Gly Arg Asn Leu Met Glu Ser Arg Gly Lys His Arg Leu Lys Lys 1040 1045 1050 Asn Gly Gly Lys Leu Val Phe Asn Pro Glu Lys Pro Ser Leu Thr 1055 1060 1065 Trp Leu Val Glu Cys Glu Thr Gln Cys Lys Tyr Cys Gly Ser Asp 1070 1075 1080 Ala Phe Ser Pro Arg Thr Val Phe Leu Ala Pro Lys Leu Tyr Ala 1085 1090 1095 Leu Gln Lys Leu Val Cys Pro Thr Cys Gly Gln Glu Gly Ala Gly 1100 1105 1110 Lys Leu Arg Ala Lys Gly His Ala Val Ala Ser Leu Ser Tyr Asp 1115 1120 1125 Ile Leu Leu Ala Cys Tyr Glu Ala Tyr Arg Leu Asn Glu Ser Asp 1130 1135 1140 Pro Asn Phe Tyr Thr Ser Arg Gln Ser Leu Lys Arg Thr Leu Val 1145 1150 1155 Asn Met Asn Lys Gln Glu Ser Ala Phe Thr Val Thr Glu Thr Val 1160 1165 1170 Leu Thr Arg Ser Leu Arg Pro Trp Gln Asn Pro Thr Leu Ala Leu 1175 1180 1185 Leu Glu Asp Gly Arg Leu Ile Pro Tyr Ser Thr Ala His Pro Asn 1190 1195 1200 Pro Arg Asn Arg Glu Thr Thr Trp Ile Ala Leu 1205 1210 <210> 20 <211> 1023 <212> PRT <213> Bovine adenovirus 3 <400> 20 Met Cys Val Tyr Lys Thr Tyr Lys Gly Lys Leu Lys Ile Thr Ser Ile 1 5 10 15 Pro Ala Arg Ala Asp Arg Pro Arg Leu Pro Phe Pro Leu Asn Phe Leu 20 25 30 Ile His Lys Arg Lys Leu Tyr Leu Ile Asp Thr Ile Ala Glu Val Gln 35 40 45 Arg Cys Ala Asp Cys Gly Ser Tyr Phe Lys Gln Thr His Thr Cys Ser 50 55 60 Thr Arg Arg Arg Asp Phe Tyr Phe His His Ile Asn Thr Gln Ser Ser 65 70 75 80 Asp Trp Trp Glu Glu Ile Lys Phe Phe Pro Trp Ala Ala His Pro Asp 85 90 95 Thr Arg Arg Leu Phe Val Val Tyr Asp Val Glu Thr Tyr Thr Trp His 100 105 110 Gly Ser Phe Gly Lys Gln Leu Met Pro Phe Met Leu Val Phe Thr Leu 115 120 125 Phe Gly Asp Ala Gln Leu Cys Glu Gln Ala Val Asn Ile Ala Lys Lys 130 135 140 Gln Lys Trp Ser Ser Trp Pro Lys Gln Ala Asn Thr Phe Tyr Tyr Leu 145 150 155 160 Asn Pro Gln Arg Asn Lys Val Gly Ser Leu Phe Lys Gln Tyr Arg Asp 165 170 175 Ala Leu Gln Glu Ala Ala Ser Thr Leu Leu Trp Arg Gln Phe Leu Ala 180 185 190 Asp Asn Pro Cys Leu Glu Asn Leu Cys Leu Lys Leu Gly Tyr Val His 195 200 205 Ala Ser Asp Ile Pro Phe Glu Glu Leu Cys Thr Leu Glu Leu Lys Gly 210 215 220 Gln Pro Thr Phe Leu Glu Val Tyr Val Val Gly His Asn Ile Asn Gly 225 230 235 240 Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile Asn Asn Lys Gln Gly 245 250 255 Ile Pro Ala Ala Phe Lys Val Ser Arg Asn Phe Met Pro Arg Cys Gly 260 265 270 Lys Ile Leu Phe Asn Asp Leu Thr Phe Ala Leu Pro Asn Pro Thr His 275 280 285 Ala Ala Arg Lys Asp Phe Lys Asp Trp Glu Glu Gly Thr Pro Thr Ser 290 295 300 Ala Asp Tyr Lys Phe Gln Phe Val Lys Phe Met Val Arg Asp Thr Phe 305 310 315 320 Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala Ala Ala Tyr Ala Leu 325 330 335 Pro Val Glu Lys Gly Cys Cys Pro Tyr Lys Ala Val Asn Glu Phe Tyr 340 345 350 Met Leu Gly Thr Tyr Arg Thr Asp Ala Asp Ser Phe Pro Gln Arg Asp 355 360 365 Tyr Trp Ser Ser Asp Glu Glu Tyr Leu Leu Asn Lys Ser Leu Trp Leu 370 375 380 Gln Glu Asn Ser Gly Ala Tyr Asp Ile Val Gln Arg Thr Leu Asp Tyr 385 390 395 400 Cys Ala Met Asp Val Leu Val Thr Ala Glu Leu Val Lys Lys Leu Gln 405 410 415 Ala Ser Tyr Leu Asp Phe Val His Thr Ser Val Gly Leu Pro His Cys 420 425 430 Asn Phe Asn Val Leu Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala 435 440 445 Ile Phe Arg Gln Val Val Tyr Arg Ser Gln Arg Pro Asn Arg Ser Ser 450 455 460 Leu Gly Asn Phe Leu Leu Ala Pro Ser Asn Glu Met Tyr Asp Tyr Val 465 470 475 480 Arg Glu Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val 485 490 495 Leu Thr Glu Ala Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser 500 505 510 Ala Leu Thr His Pro Phe Pro Ala Gly Lys Pro Leu Asn Pro Phe Asp 515 520 525 Arg Ala Leu Ala Ile Lys Asn Trp Gln Asp Arg Leu Thr Gln Leu His 530 535 540 Arg Pro Ile Asp Tyr Phe Asp Arg Thr Leu Leu Pro Ala Ile Phe Thr 545 550 555 560 Ile Asp Ala Asp Pro Pro Pro Glu Ala Phe Leu Asp Val Ile Pro Pro 565 570 575 Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Thr Leu 580 585 590 Arg Gly Glu Val Val Thr Cys Leu Asp Ala Ile Thr Leu His Asn Arg 595 600 605 Gly Trp Arg Val Gln Ile Leu Asn Asp Pro Arg Thr Thr Val Phe Pro 610 615 620 Gln Trp Glu Cys Leu Ala Arg Asp Tyr Val Gln Leu Asn Ile Ala Pro 625 630 635 640 Lys Glu Arg Ala Asp Lys Glu Lys Asn Gln Thr Leu Arg Ser Ile Ala 645 650 655 Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp 660 665 670 Asn Arg Val Thr Val Phe Ser Asp Gln Met Glu Asp Lys Tyr Val Arg 675 680 685 Gly Ile Ser Asp Gly Thr Tyr Asp Ile Lys Ser Thr Ala Phe Val Glu 690 695 700 Thr Asp Asn Leu Ser Ser Ser Val Met Ala Glu Leu Lys Ile Thr Tyr 705 710 715 720 Ser Pro Val Lys Gln Gln Thr Asp Ala Thr Arg Lys His Arg Gln Cys 725 730 735 Thr Pro Thr Ser Asn Ser Ser Ser Asp Glu Asp Ala Pro Phe Tyr Thr 740 745 750 Leu Gly Asp Pro Gln Asn His His Val Thr Tyr Thr Tyr Lys Pro Ile 755 760 765 Thr Phe Leu Glu Ala Asp Asp Ser Ala Leu Cys Leu His Thr Leu Gln 770 775 780 Lys Lys Ser Ser Leu Ile Phe Asn Asn Arg Tyr Pro Ser His Ile Ala 785 790 795 800 Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Asp 805 810 815 Ile Leu Tyr Leu Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Ile Leu 820 825 830 Lys Phe Val Tyr Gly Asp Thr Asp Ser Met Phe Leu Thr Gln Arg Gly 835 840 845 Lys Glu Leu Met Asp Thr Arg Gly Lys His Arg Leu Lys Gly Asn Asn 850 855 860 Arg Pro Leu Val Phe Asp Pro Thr Asn Pro Gln Leu Thr Trp Leu Val 865 870 875 880 Glu Cys Glu Thr Gln Cys Pro Arg Cys His Gly Asp Ala His Ser Gln 885 890 895 Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asn Ile Tyr 900 905 910 Cys Pro Ser Cys Arg Arg Arg Glu Phe Trp Gln Thr Ser Ser Lys Gly 915 920 925 His Ala Thr Ser Gln Leu Ser Tyr Asp Leu Leu Val Thr Cys Tyr Tyr 930 935 940 Ser Thr Glu Gln Leu Gly Asp Glu Lys Phe Gly Thr Ser Arg Leu Ser 945 950 955 960 Leu Arg Arg Ser Leu Val Ser Arg Gln Thr His Gln Gln Pro Phe Thr 965 970 975 Val Thr Glu Thr Thr Leu Ala Arg Thr Leu Arg Pro Trp Lys Asp Arg 980 985 990 Thr Leu Arg Ala Ile Asp Arg His Arg Leu Ala Pro Tyr Ser Asn Ser 995 1000 1005 His Pro Asn Pro Arg Asn Lys Glu Leu Cys Trp Met Glu Met Tyr 1010 1015 1020 <210> 21 <211> 1163 <212> PRT <213> Bovine adenovirus B <400> 21 Met Ala Leu Val Gln Ser Asp Gly Ala Ser Ser Ile His Pro Thr Pro 1 5 10 15 Gly Asp Ser Glu Asn Gln Pro Gln Ser Arg Ala Ala Arg Ile Arg Pro 20 25 30 Ala Pro Thr Ala Ala Thr His Ala Arg Thr Gln Arg Ser Gly Pro Ala 35 40 45 Thr Ala Pro Gln Ala Arg Lys Ala Lys Ala Ala Pro Arg Pro Ser Thr 50 55 60 Ser Pro Leu Lys Lys Ala Pro Arg Gly Pro Leu Val Ala Lys Arg Ser 65 70 75 80 Thr Leu Arg Leu His Gly Gln Thr Glu Asp Gly Thr Thr Leu Glu Val 85 90 95 Lys Tyr His Ala Asp Val Ser Ser Ser Leu Arg Asn Leu Phe Glu Leu 100 105 110 His Leu Glu His Cys Pro Phe Asp Leu Lys Pro Glu Asn Ile Leu Ser 115 120 125 Phe Gln Asp Thr Leu Val Arg Phe Cys Asn Ala Asn Met Cys Val Tyr 130 135 140 Lys Thr Tyr Lys Gly Lys Leu Lys Ile Thr Ser Ile Pro Ala Arg Ala 145 150 155 160 Asp Arg Pro Arg Leu Pro Phe Pro Leu Asn Phe Leu Ile His Lys Arg 165 170 175 Lys Leu Tyr Leu Ile Asp Thr Ile Ala Glu Val Gln Arg Cys Ala Asp 180 185 190 Cys Gly Ser Tyr Phe Lys Gln Thr His Thr Cys Ser Thr Arg Arg Arg 195 200 205 Asp Phe Tyr Phe His His Ile Asn Thr Gln Ser Ser Asp Trp Trp Glu 210 215 220 Glu Ile Lys Phe Phe Pro Trp Ala Ala His Pro Asp Thr Arg Arg Leu 225 230 235 240 Phe Val Val Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Ser Phe Gly 245 250 255 Lys Gln Leu Met Pro Phe Met Leu Val Phe Thr Leu Phe Gly Asp Ala 260 265 270 Gln Leu Cys Glu Gln Ala Val Asn Ile Ala Lys Lys Gln Lys Trp Ser 275 280 285 Ser Trp Pro Lys Gln Ala Asn Thr Phe Tyr Tyr Leu Asn Pro Gln Arg 290 295 300 Asn Lys Val Gly Ser Leu Phe Lys Gln Tyr Arg Asp Ala Leu Gln Glu 305 310 315 320 Ala Ala Ser Thr Leu Leu Trp Arg Gln Phe Leu Ala Asp Asn Pro Cys 325 330 335 Leu Glu Asn Leu Cys Leu Lys Leu Gly Tyr Val His Ala Ser Asp Ile 340 345 350 Pro Phe Glu Glu Leu Cys Thr Leu Glu Leu Lys Gly Gln Pro Thr Phe 355 360 365 Leu Glu Val Tyr Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile 370 375 380 Val Leu Ala Ala Gln Val Ile Asn Asn Lys Gln Gly Ile Pro Ala Ala 385 390 395 400 Phe Lys Val Ser Arg Asn Phe Met Pro Arg Cys Gly Lys Ile Leu Phe 405 410 415 Asn Asp Leu Thr Phe Ala Leu Pro Asn Pro Thr His Ala Ala Arg Lys 420 425 430 Asp Phe Lys Asp Trp Glu Glu Gly Thr Pro Thr Ser Ala Asp Tyr Lys 435 440 445 Phe Gln Phe Val Lys Phe Met Val Arg Asp Thr Phe Ala Leu Thr His 450 455 460 Thr Ser Leu Arg Asn Ala Ala Ala Ala Tyr Ala Leu Pro Val Glu Lys 465 470 475 480 Gly Cys Cys Pro Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Thr 485 490 495 Tyr Arg Thr Asp Ala Asp Ser Phe Pro Gln Arg Asp Tyr Trp Ser Ser 500 505 510 Asp Glu Glu Tyr Leu Leu Asn Lys Ser Leu Trp Leu Gln Glu Asn Ser 515 520 525 Gly Ala Tyr Asp Ile Val Gln Arg Thr Leu Asp Tyr Cys Ala Met Asp 530 535 540 Val Leu Val Thr Ala Glu Leu Val Lys Lys Leu Gln Ala Ser Tyr Leu 545 550 555 560 Asp Phe Val His Thr Ser Val Gly Leu Pro His Cys Asn Phe Asn Val 565 570 575 Leu Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln 580 585 590 Val Val Tyr Arg Ser Gln Arg Pro Asn Arg Ser Ser Leu Gly Asn Phe 595 600 605 Leu Leu Ala Pro Ser Asn Glu Met Tyr Asp Tyr Val Arg Glu Ser Ile 610 615 620 Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Thr Glu Ala 625 630 635 640 Ile Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His 645 650 655 Pro Phe Pro Ala Gly Lys Pro Leu Asn Pro Phe Asp Arg Ala Leu Ala 660 665 670 Ile Lys Asn Trp Gln Asp Arg Leu Thr Gln Leu His Arg Pro Ile Asp 675 680 685 Tyr Phe Asp Arg Thr Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp 690 695 700 Pro Pro Pro Glu Ala Phe Leu Asp Val Ile Pro Pro Phe Cys Ser Arg 705 710 715 720 Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Thr Leu Arg Gly Glu Val 725 730 735 Val Thr Cys Leu Asp Ala Ile Thr Leu His Asn Arg Gly Trp Arg Val 740 745 750 Gln Ile Leu Asn Asp Pro Arg Thr Thr Val Phe Pro Gln Trp Glu Cys 755 760 765 Leu Ala Arg Asp Tyr Val Gln Leu Asn Ile Ala Pro Lys Glu Arg Ala 770 775 780 Asp Lys Glu Lys Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser 785 790 795 800 Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Arg Val Thr 805 810 815 Val Phe Ser Asp Gln Met Glu Asp Lys Tyr Val Arg Gly Ile Ser Asp 820 825 830 Gly Thr Tyr Asp Ile Lys Ser Thr Ala Phe Val Glu Thr Asp Asn Leu 835 840 845 Ser Ser Ser Val Met Ala Glu Leu Lys Ile Thr Tyr Ser Pro Val Lys 850 855 860 Gln Gln Thr Asp Ala Thr Arg Lys His Arg Gln Cys Thr Pro Thr Ser 865 870 875 880 Asn Ser Ser Ser Asp Glu Asp Ala Pro Phe Tyr Thr Leu Gly Asp Pro 885 890 895 Gln Asn His His Val Thr Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Glu 900 905 910 Ala Asp Asp Ser Ala Leu Cys Leu His Thr Leu Gln Lys Lys Ser Ser 915 920 925 Leu Ile Phe Asn Asn Arg Tyr Pro Ser His Ile Ala Ser Phe Val Leu 930 935 940 Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Asp Ile Leu Tyr Leu 945 950 955 960 Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Ile Leu Lys Phe Val Tyr 965 970 975 Gly Asp Thr Asp Ser Met Phe Leu Thr Gln Arg Gly Lys Glu Leu Met 980 985 990 Asp Thr Arg Gly Lys His Arg Leu Lys Gly Asn Asn Arg Pro Leu Val 995 1000 1005 Phe Asp Pro Thr Asn Pro Gln Leu Thr Trp Leu Val Glu Cys Glu 1010 1015 1020 Thr Gln Cys Pro Arg Cys His Gly Asp Ala His Ser Gln Glu Ser 1025 1030 1035 Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asn Ile Tyr Cys 1040 1045 1050 Pro Ser Cys Arg Arg Arg Glu Phe Trp Gln Thr Ser Ser Lys Gly 1055 1060 1065 His Ala Thr Ser Gln Leu Ser Tyr Asp Leu Leu Val Thr Cys Tyr 1070 1075 1080 Tyr Ser Thr Glu Gln Leu Gly Asp Glu Lys Phe Gly Thr Ser Arg 1085 1090 1095 Leu Ser Leu Arg Arg Ser Leu Val Ser Arg Gln Thr His Gln Gln 1100 1105 1110 Pro Phe Thr Val Thr Glu Thr Thr Leu Ala Arg Thr Leu Arg Pro 1115 1120 1125 Trp Lys Asp Arg Thr Leu Arg Ala Ile Asp Arg His Arg Leu Ala 1130 1135 1140 Pro Tyr Ser Asn Ser His Pro Asn Pro Arg Asn Lys Glu Leu Cys 1145 1150 1155 Trp Met Glu Met Tyr 1160 <210> 22 <211> 1192 <212> PRT <213> Simian adenovirus 22 <400> 22 Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala 1 5 10 15 Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser 20 25 30 Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro 35 40 45 Ala Ala Pro Ala Ser Gly Pro Arg Ala Ala Pro Ala Ala Arg Arg Ala 50 55 60 Ser Ser Pro Pro Leu Leu Ser Met Glu Pro Pro Pro Pro Ala Pro Lys 65 70 75 80 Lys Lys Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln 85 90 95 Ala Val Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu 100 105 110 Asp Leu Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro 115 120 125 Pro Leu Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser 130 135 140 Ser Gly Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu 145 150 155 160 Val Trp Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu 165 170 175 Ala Asp Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Gln Met 180 185 190 Gln Pro Pro Ala Leu His Cys Pro Leu Lys Phe Leu Val Lys Gly Thr 195 200 205 Gln Val Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His 210 215 220 Cys Gly Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg 225 230 235 240 His Phe Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln 245 250 255 Glu Ile Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu 260 265 270 Phe Leu Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly 275 280 285 Lys Gln Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro 290 295 300 Pro Leu Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp 305 310 315 320 Arg Trp His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys 325 330 335 Met Ala Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr 340 345 350 Ala Leu Ala Val Asp Leu Trp Thr Ser Phe Leu Gly Ala Asn Pro His 355 360 365 Leu Ala Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu 370 375 380 Leu Thr Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro 385 390 395 400 Arg Phe Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp 405 410 415 Glu Ile Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro 420 425 430 Gln Pro Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile 435 440 445 Leu Phe Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys 450 455 460 Arg Thr Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp 465 470 475 480 Phe Lys His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu 485 490 495 Thr His Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val 500 505 510 Glu Lys Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val 515 520 525 Gly Ser Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp 530 535 540 Lys Asp Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys 545 550 555 560 Gly Gln Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala 565 570 575 Leu Asp Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser 580 585 590 Tyr Ala His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe 595 600 605 Asn Ile Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe 610 615 620 Arg Gln Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly 625 630 635 640 Thr Gly Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala 645 650 655 Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu 660 665 670 Glu Pro Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu 675 680 685 Thr His Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala 690 695 700 Leu Ala Val Arg Asp Trp Gln Ala Ala Leu Asp Asp Leu Gly Thr Cys 705 710 715 720 Ile Ser Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp 725 730 735 Ala Asp Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys 740 745 750 Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly 755 760 765 Glu Val Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp 770 775 780 Arg Val Arg Ile Val Pro Asp Lys Leu Thr Thr Val Phe Pro Glu Trp 785 790 795 800 Lys Cys Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu 805 810 815 Arg Ala Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu 820 825 830 Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys 835 840 845 Lys Ile Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val 850 855 860 Ser Asn Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp 865 870 875 880 Asn Leu Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro 885 890 895 Gln Gln Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu 900 905 910 Gln Gly Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His 915 920 925 Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly 930 935 940 Asp Met Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn 945 950 955 960 Asp Arg Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg 965 970 975 Ala Phe Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly 980 985 990 Thr Pro Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp 995 1000 1005 Ser Leu Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg 1010 1015 1020 Gly Lys Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp 1025 1030 1035 Pro Asp Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val 1040 1045 1050 Cys Ala Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe 1055 1060 1065 Leu Ala Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val 1070 1075 1080 Cys Gly His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala 1085 1090 1095 Ala Glu Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala 1100 1105 1110 Asp Ala Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met 1115 1120 1125 Ser Leu Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro 1130 1135 1140 Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp 1145 1150 1155 Lys Asp Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro 1160 1165 1170 Tyr Ser Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp 1175 1180 1185 Ile Glu Met Pro 1190 <210> 23 <211> 1190 <212> PRT <213> Simian adenovirus 23 <400> 23 Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala 1 5 10 15 Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser 20 25 30 Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro 35 40 45 Ala Ala Pro Ala Ser Gly Pro Arg Ala Ala Pro Ala Ala Arg Arg Ala 50 55 60 Ser Ser Pro Pro Leu Leu Thr Asp Met Glu Ala Ala Pro Lys Lys Lys 65 70 75 80 Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln Ala Val 85 90 95 Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu Asp Leu 100 105 110 Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro Pro Leu 115 120 125 Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser Ser Gly 130 135 140 Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu Val Trp 145 150 155 160 Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu Ala Asp 165 170 175 Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Glu Met Gln Pro 180 185 190 Pro Ala Leu His Cys Pro Leu Lys Phe Leu Ala Lys Gly Thr Gln Val 195 200 205 Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His Cys Gly 210 215 220 Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg His Phe 225 230 235 240 Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln Glu Ile 245 250 255 Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu 260 265 270 Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln 275 280 285 Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro Pro Leu 290 295 300 Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp Arg Trp 305 310 315 320 His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys Met Ala 325 330 335 Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr Ala Leu 340 345 350 Ala Val Asp Leu Trp Thr Ser Phe Leu Ser Ala Asn Pro His Val Ala 355 360 365 Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu Leu Thr 370 375 380 Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro Arg Phe 385 390 395 400 Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile 405 410 415 Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro Gln Pro 420 425 430 Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe 435 440 445 Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys Arg Thr 450 455 460 Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp Phe Lys 465 470 475 480 His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His 485 490 495 Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys 500 505 510 Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val Gly Ser 515 520 525 Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp Lys Asp 530 535 540 Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys Gly Gln 545 550 555 560 Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala Leu Asp 565 570 575 Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser Tyr Ala 580 585 590 His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe Asn Ile 595 600 605 Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln 610 615 620 Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly Thr Gly 625 630 635 640 Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile 645 650 655 Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu Glu Pro 660 665 670 Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His 675 680 685 Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala 690 695 700 Val Arg Asp Trp Gln Ala Ala Leu Asp Asn Leu Gly Thr Cys Ile Ser 705 710 715 720 Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp Ala Asp 725 730 735 Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg 740 745 750 Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val 755 760 765 Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val 770 775 780 Arg Ile Val Pro Asp Glu Leu Thr Thr Val Phe Pro Glu Trp Lys Cys 785 790 795 800 Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala 805 810 815 Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser 820 825 830 Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile 835 840 845 Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val Ser Asn 850 855 860 Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp Asn Leu 865 870 875 880 Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro Gln Gln 885 890 895 Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu Gln Gly 900 905 910 Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His Val Ala 915 920 925 Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly Asp Met 930 935 940 Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn Asp Arg 945 950 955 960 Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe 965 970 975 Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly Thr Pro 980 985 990 Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu 995 1000 1005 Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg Gly Lys 1010 1015 1020 Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp Pro Asn 1025 1030 1035 Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Ala 1040 1045 1050 Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe Leu Ala 1055 1060 1065 Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val Cys Gly 1070 1075 1080 His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala Ala Glu 1085 1090 1095 Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala Asp Ala 1100 1105 1110 Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met Ser Leu 1115 1120 1125 Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro Phe Thr 1130 1135 1140 Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp 1145 1150 1155 Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro Tyr Ser 1160 1165 1170 Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp Ile Glu 1175 1180 1185 Met Pro 1190 <210> 24 <211> 1190 <212> PRT <213> Simian adenovirus 24 <400> 24 Met Ala Leu Val Gln Thr His Gly Ser Arg Gly Leu His Pro Glu Ala 1 5 10 15 Ser Asp Pro Gly Arg Gln Pro Ser Arg Arg Arg Ser Arg Gln Ser Ser 20 25 30 Pro Gly Ala Val Pro Glu Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro 35 40 45 Ala Ala Pro Ala Ser Gly Ser Arg Ala Ala Pro Ala Ala Arg Arg Ala 50 55 60 Ser Ser Pro Pro Leu Leu Thr Gly Met Glu Ala Ala Pro Lys Lys Lys 65 70 75 80 Arg Gly Thr Val Val Ala Pro Gln Gly His Gly Thr Leu Gln Ala Val 85 90 95 Asp Val Ala Thr Asn Gly Ala Val Glu Ile Lys Tyr His Leu Asp Leu 100 105 110 Pro Arg Ala Leu Glu Lys Leu Leu Gln Val Asn Arg Ala Pro Pro Leu 115 120 125 Pro Thr Asp Leu Thr Pro Gln Arg Leu Arg Thr Leu Asp Ser Ser Gly 130 135 140 Leu Arg Ala Leu Val Leu Ala Leu Arg Pro Val Arg Ala Glu Val Trp 145 150 155 160 Thr Cys Leu Pro Arg Gly Leu Val Ser Met Thr Thr Ile Glu Ala Asp 165 170 175 Asp Gly His Ala Asp Gly Gln Asp Val Val Gln His Gln Met Gln Pro 180 185 190 Pro Ala Leu His Cys Pro Leu Lys Phe Leu Val Lys Gly Thr Gln Val 195 200 205 Gln Leu Val Gln His Val His Pro Val Gln Arg Cys Glu His Cys Gly 210 215 220 Arg Leu Tyr Lys His Lys His Glu Cys Ser Ala Arg Arg Arg His Phe 225 230 235 240 Tyr Phe His His Ile Asn Ser His Ser Ser Asn Trp Trp Gln Glu Ile 245 250 255 Gln Phe Phe Pro Ile Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu 260 265 270 Thr Tyr Asp Val Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln 275 280 285 Leu Val Pro Phe Met Leu Val Met Lys Leu Ser Gly Asp Pro Pro Leu 290 295 300 Val Glu Leu Ala His Asp Leu Ala Leu Gln Leu Lys Trp Asp Arg Trp 305 310 315 320 His Gly Asp Pro Arg Thr Phe Tyr Cys Val Thr Pro Glu Lys Met Ala 325 330 335 Val Gly Gln Gln Phe Arg Gln Tyr Arg Asp Arg Leu Gln Thr Ala Leu 340 345 350 Ala Val Asp Leu Trp Thr Ser Phe Leu Ser Ala Asn Pro His Val Ala 355 360 365 Asp Trp Ala Leu Glu Gln His Gly Leu Ser Asp Pro Ala Glu Leu Thr 370 375 380 Tyr Asp Glu Leu Lys Lys Leu Pro His Val Lys Gly Arg Pro Arg Phe 385 390 395 400 Val Glu Leu Tyr Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile 405 410 415 Val Leu Ala Ala Gln Val Ile Asn Asn Arg Ala Glu Val Pro Gln Pro 420 425 430 Phe Arg Ile Thr Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe 435 440 445 Asn Asp Val Thr Phe Ala Leu Pro Asn Pro Ala Tyr Lys Lys Arg Thr 450 455 460 Asp Phe Gln Leu Trp Glu Gln Gly Gly Cys Asp Asp Leu Asp Phe Lys 465 470 475 480 His Gln Phe Leu Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His 485 490 495 Thr Ser Leu Arg Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys 500 505 510 Gly Cys Cys Ala Tyr Lys Ala Val Asn Gln Phe Tyr Met Val Gly Ser 515 520 525 Tyr Arg Ala Asp Gln Asp Gly Phe Pro Leu Glu Glu Tyr Trp Lys Asp 530 535 540 Arg Glu Glu Phe Leu Leu Asn Arg Glu Leu Trp Lys Gln Lys Gly Gln 545 550 555 560 Leu Lys Tyr Asp Ile Ile Gln Glu Thr Leu Asp Tyr Cys Ala Leu Asp 565 570 575 Val Leu Val Thr Ala Glu Leu Val Ala Lys Leu Gln Asp Ser Tyr Ala 580 585 590 His Phe Ile Arg Asp Ser Val Gly Leu Pro His Ala His Phe Asn Ile 595 600 605 Phe Gln Arg Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln 610 615 620 Ile Val Tyr Arg Ala Glu Lys Pro Gln Arg Ser Asn Leu Gly Thr Gly 625 630 635 640 Leu Leu Ala Pro Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile 645 650 655 Arg Gly Gly Arg Cys Tyr Pro Thr Tyr Ile Gly Val Leu Glu Glu Pro 660 665 670 Leu Tyr Val Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His 675 680 685 Pro Met Pro Trp Gly Thr Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala 690 695 700 Val Arg Asp Trp Gln Ala Ala Leu Asp Asp Leu Asp Thr Cys Ile Ser 705 710 715 720 Tyr Phe Asp Pro Glu Leu Leu Pro Gly Ile Phe Thr Val Asp Ala Asp 725 730 735 Pro Pro Asp Glu Leu Met Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg 740 745 750 Lys Gly Gly Arg Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val 755 760 765 Ala Thr Ser Val Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val 770 775 780 Arg Ile Val Pro Asp Glu Leu Thr Thr Val Phe Pro Glu Trp Lys Cys 785 790 795 800 Val Ala Arg Glu Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala 805 810 815 Asp Lys Glu Lys Asn Gln Thr Met Arg Ser Ile Ala Lys Leu Leu Ser 820 825 830 Asn Ala Leu Tyr Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile 835 840 845 Val Phe Ser Asp Gln Met Asp Glu Gly Leu Met Lys Gly Val Ser Asn 850 855 860 Gly Thr Val Asn Ile Lys Ser Ser Ser Phe Leu Glu Thr Asp Asn Leu 865 870 875 880 Ser Ala Glu Val Met Pro Ala Phe Glu Arg Glu Tyr Leu Pro Gln Gln 885 890 895 Leu Ala Leu Leu Asp Ser Asp Pro Glu Asp Ser Glu Asp Glu Gln Gly 900 905 910 Pro Ala Pro Phe Tyr Thr Pro Pro Ala Gly Thr Pro Gly His Val Ala 915 920 925 Tyr Thr Tyr Lys Pro Ile Thr Phe Leu Asp Val Asp Glu Gly Asp Met 930 935 940 Cys Leu His Thr Leu Glu Lys Val Asp Pro Leu Val Asp Asn Asp Arg 945 950 955 960 Tyr Pro Ser His Val Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe 965 970 975 Val Ser Glu Trp Ala Gly Phe Leu Tyr Asp Glu Asp Arg Gly Thr Pro 980 985 990 Leu Glu Asp Arg Pro Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu 995 1000 1005 Phe Val Thr Gln Arg Gly His Glu Leu Met Glu Thr Arg Gly Lys 1010 1015 1020 Lys Arg Ile Lys Lys His Gly Gly Asn Leu Val Phe Asp Pro Asn 1025 1030 1035 Arg Pro Asp Leu Thr Trp Leu Val Glu Cys Glu Thr Val Cys Ala 1040 1045 1050 Ser Cys Gly Ala Asp Ala Tyr Ala Pro Glu Ser Val Phe Leu Ala 1055 1060 1065 Pro Lys Leu Tyr Ala Leu Lys Ser Leu Leu Cys Pro Val Cys Gly 1070 1075 1080 His Thr Ser Lys Gly Lys Leu Arg Ala Lys Gly His Ala Ala Glu 1085 1090 1095 Ala Leu Asn Tyr Glu Leu Met Leu Asn Cys Tyr Leu Ala Asp Ala 1100 1105 1110 Gln Gly Ala Asp Arg Glu Arg Phe Ser Thr Ser Arg Met Ser Leu 1115 1120 1125 Lys Arg Thr Leu Ala Ser Ala Gln Pro Gly Ala His Pro Phe Thr 1130 1135 1140 Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp 1145 1150 1155 Arg Thr Leu Ala Ser Leu Asp Ala His Arg Leu Val Pro Tyr Ser 1160 1165 1170 Arg Ser Arg Pro Asn Pro Arg Asn Glu Glu Val Cys Trp Ile Glu 1175 1180 1185 Met Pro 1190 <210> 25 <211> 1184 <212> PRT <213> Simian adenovirus 7 <400> 25 Met Ala Leu Val Gln Asp Pro Gly Ala Gly Gly Leu His Ala Glu Thr 1 5 10 15 Ala His Pro Gly Pro Gln Pro Pro Arg Arg Arg Pro Arg Gln Gln Ser 20 25 30 Pro Gly Ser Ser Ser Thr Ala Ala Glu Ser Ser Arg Lys Arg Ala Ser 35 40 45 Ala Ser Ala Ala Pro Arg Arg Arg Ala Ala Ser Thr Pro Arg Arg Ser 50 55 60 Pro Ser Thr Ser Glu Ile Lys Pro Pro Arg Gly Thr Val Val Ala Pro 65 70 75 80 Arg Gly His Gly Leu Leu Tyr Ala Val Asp Ala Ser Ser Asn Thr Pro 85 90 95 Leu Glu Ile Lys Tyr His Leu His Leu Ala His Ala Leu Thr Gly Leu 100 105 110 Leu Lys Val Asn Leu Gln Thr Leu Pro Ala Asp Leu Ser Ala Thr Ser 115 120 125 Leu Asp Ser Leu Asp Ser Gly Gln Leu Arg Pro Leu Leu Gln Arg Leu 130 135 140 His Pro Ser Val Ala Glu Ile Trp Thr Cys Gly Thr Arg Gly Val Val 145 150 155 160 Val Pro Thr Val Val His Pro Glu Lys Glu Asp Ala Asp Ala Asp Ser 165 170 175 His Arg Gln Gly Glu Gly Asp Val Ala Pro Pro Ala Pro Arg Leu Asn 180 185 190 Phe Pro Leu Arg Phe Leu Val Arg Gly Arg Lys Ala His Leu Val Gln 195 200 205 Glu Ile Gln Ser Val Gln Arg Cys Asp Tyr Cys Gly Arg Phe Tyr Lys 210 215 220 His Gln His Glu Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His His 225 230 235 240 Ile Asn Thr His Ser Ser Ser Trp Trp Gln Glu Ile Ser Phe Phe Pro 245 250 255 Ile Gly Ser His Ala Arg Thr Gln Arg Leu Phe Val Thr Tyr Asp Val 260 265 270 Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln Leu Val Pro Phe 275 280 285 Met Leu Val Met His Val Ser Gly Glu Glu Thr Leu Val Arg Gln Ala 290 295 300 Cys Glu Leu Ala Leu Glu Leu Arg Trp Asp Val Trp Asn Asn Arg Pro 305 310 315 320 Asn Thr Phe Tyr Val Val Thr Pro Glu Lys Met Ala Val Gly Lys Lys 325 330 335 Phe Arg Glu Phe Arg Asp Arg Leu Gln Thr Leu Leu Ala Leu Asp Leu 340 345 350 Trp Ser Ser Phe Leu Ala Ala Asn Pro Gln Leu Ser Asp Trp Ala Arg 355 360 365 Ala Glu Leu Gly Leu Ser Ser Pro Asp Cys Leu Thr Tyr Glu Glu Leu 370 375 380 Lys Lys Ala Pro Ala Leu Lys Gly Gln Pro Arg Phe Ile Glu Leu Tyr 385 390 395 400 Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala 405 410 415 Gln Val Ile Asn Asn Arg Ser Asp Val Pro Gly Pro Phe Arg Ile Ser 420 425 430 Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr 435 440 445 Phe Ala Leu Pro Asn Pro Arg Gln Lys Lys Arg Thr Asp Phe Thr Leu 450 455 460 Trp Glu Gln Gly Ala Cys Asp Asp Thr Asp Phe Lys His Gln Tyr Leu 465 470 475 480 Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg 485 490 495 Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Pro 500 505 510 Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Ser Tyr Arg Ala Asp 515 520 525 Glu Lys Gly Phe Pro Ala Glu Glu Tyr Trp Lys Asp Arg Glu Glu Tyr 530 535 540 Leu Leu Asn Arg Glu Leu Trp Glu Lys Lys Gln Glu Thr Ala Tyr Asn 545 550 555 560 Leu Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr 565 570 575 Ala Ala Leu Val Asp Lys Leu Arg Glu Ser Tyr Ala Gln Phe Ile Gln 580 585 590 Asp Ser Val Gly Leu Pro Gly Ala Asn Phe Asn Val Phe Gln Arg Pro 595 600 605 Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Tyr Arg 610 615 620 Ala Glu Lys Pro His Lys Thr His Leu Gly Asp Gly Leu Met Ala Pro 625 630 635 640 Ser Arg Glu Met Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg 645 650 655 Cys Tyr Pro Thr Tyr Ile Gly Val Leu Arg Glu Pro Leu Tyr Val Tyr 660 665 670 Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp 675 680 685 Gly Pro Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Val Lys Lys Trp 690 695 700 Glu Asp Ala Leu Gln Asp Thr Asp Thr Glu Ile Asp Tyr Phe Asn Lys 705 710 715 720 Ile Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Pro Ala 725 730 735 Asn Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg 740 745 750 Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val 755 760 765 Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Ile Leu Pro 770 775 780 Asp Glu Arg Thr Ala Val Phe Pro Glu Trp Arg Cys Ala Ala Arg Glu 785 790 795 800 Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Glu Lys 805 810 815 Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr 820 825 830 Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp 835 840 845 Gln Met Asp Pro Ser Thr Ile Lys Ser Ile Ala Ala Gly His Val Asn 850 855 860 Ile Lys Ser Thr Ser Phe Val Glu Thr Asp Asn Leu Ser Ala Glu Ile 865 870 875 880 Met Pro Ala Phe Glu Arg Ala Tyr Ser Pro Glu Gln Leu Ala Leu Val 885 890 895 His Ser Asp Ala Glu Glu Ser Asp Gly Glu Gly Gly His Ala Pro Phe 900 905 910 Tyr Thr Pro Leu Gly Gly Ala Asp His Val Thr Tyr Thr Tyr Lys Pro 915 920 925 Ile Thr Phe Val Asp Ala Glu Glu Asp Asp Leu Cys Leu His Thr Leu 930 935 940 Glu Lys Val Asp Pro Leu Ile Glu Asn Asp Arg Tyr Pro Ser Gln Ile 945 950 955 960 Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser 965 970 975 Gln Phe Leu Tyr Ala Glu Asp Leu Gly Thr Pro Leu Glu Asp Arg Pro 980 985 990 Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala 995 1000 1005 Gly His Lys Leu Met Glu Thr Gln Gly Lys Lys Arg Ile Lys Lys 1010 1015 1020 Asn Gly Gly Asn Leu Val Phe Asp Pro Ala Lys Pro Glu Leu Thr 1025 1030 1035 Trp Leu Val Glu Cys Glu Thr Val Cys Ala Gln Cys Gly Ala Asp 1040 1045 1050 Ala Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala 1055 1060 1065 Leu Gln Cys Leu His Cys Thr Lys Cys Gln His Val Ser Lys Gly 1070 1075 1080 Lys Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Ser Tyr Asp 1085 1090 1095 Leu Met Leu Arg Cys Tyr Leu Ala Asp Ser Gln Gly Asp Asp Val 1100 1105 1110 Arg Phe Ser Thr Ser Arg Met Ser Leu Lys Arg Thr Leu Ala Ser 1115 1120 1125 Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu 1130 1135 1140 Thr Arg Thr Leu Arg Pro Trp Lys Asp Arg Thr Leu Ala Ala Leu 1145 1150 1155 Asp Ala His Arg Leu Val Pro Tyr Ser Glu Ser Arg Pro Asn Pro 1160 1165 1170 Arg Asn Gln Glu Val Cys Trp Ile Glu Ile Pro 1175 1180 <210> 26 <211> 1184 <212> PRT <213> Simian adenovirus 1 <400> 26 Met Ala Leu Val Gln Asp Pro Gly Ala Gly Gly Leu His Ala Glu Thr 1 5 10 15 Ala His Pro Gly Pro Gln Pro Pro Arg Arg Arg Pro Arg Gln Gln Ser 20 25 30 Pro Gly Ser Ser Ser Thr Ala Ala Glu Ser Ser Arg Lys Arg Ala Thr 35 40 45 Ala Ser Ala Ala Pro Arg Arg Arg Ala Ala Ser Thr Pro Arg Arg Ser 50 55 60 Pro Ser Thr Ser Glu Ile Lys Pro Pro Arg Gly Thr Val Val Ala Pro 65 70 75 80 Arg Gly His Gly Leu Leu Tyr Ala Val Asp Ala Ser Ser Asn Thr Pro 85 90 95 Leu Glu Ile Lys Tyr His Val His Leu Ala His Ala Leu Thr Gly Leu 100 105 110 Leu Lys Val Asn Leu Gln Thr Leu Pro Ala Asp Leu Ser Ala Ala Ala 115 120 125 Leu Asp Ser Leu Asp Ser Gly Gln Leu Arg Pro Leu Leu Gln Arg Leu 130 135 140 Arg Pro Ser Val Ala Glu Ile Trp Thr Cys Gly Thr Arg Gly Val Val 145 150 155 160 Val Pro Thr Val Val His Pro Glu Lys Glu Gly Ala Asp Ala Asp Ser 165 170 175 His Arg Gln Gly Glu Gly Asp Ala Ala Pro Pro Ser Pro Arg Leu Asn 180 185 190 Phe Pro Leu Arg Phe Leu Val Arg Gly Arg Lys Ala His Leu Ile Gln 195 200 205 Glu Ile Gln Ser Val Gln Arg Cys Asp Tyr Cys Gly Arg Phe Tyr Lys 210 215 220 His Gln His Glu Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His His 225 230 235 240 Ile Asn Thr His Ser Ser Asn Trp Trp Gln Glu Ile Ser Phe Phe Pro 245 250 255 Ile Gly Ser His Ala Arg Thr Gln Arg Leu Phe Val Thr Tyr Asp Val 260 265 270 Glu Thr Tyr Thr Trp Met Gly Ser Phe Gly Lys Gln Leu Val Pro Phe 275 280 285 Met Leu Val Met His Val Ser Gly Glu Glu Thr Leu Val Arg Gln Ala 290 295 300 Cys Glu Leu Ala Leu Glu Leu Arg Trp Asp Val Trp Asn Asp Arg Pro 305 310 315 320 Cys Thr Phe Tyr Val Val Thr Pro Glu Lys Met Ala Val Gly Lys Lys 325 330 335 Phe Arg Glu Phe Arg Asp Arg Leu Gln Thr Leu Leu Ala Leu Asp Leu 340 345 350 Trp Ser Ser Phe Leu Ala Ala Asn Pro Gln Leu Ser Asp Trp Ala Arg 355 360 365 Ala Glu Leu Gly Leu Ser Ser Pro Asp Cys Leu Thr Tyr Glu Glu Leu 370 375 380 Lys Lys Ala Pro Ala Leu Lys Gly Gln Pro Arg Phe Ile Glu Leu Tyr 385 390 395 400 Ile Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala 405 410 415 Gln Val Ile Asn Asn Arg Ser Asp Val Pro Gly Pro Phe Arg Ile Ser 420 425 430 Arg Asn Phe Met Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr 435 440 445 Phe Ala Leu Pro Asn Pro Arg Gln Lys Lys Arg Thr Asp Phe Thr Leu 450 455 460 Trp Glu Gln Gly Ala Cys Asp Asp Thr Asp Phe Lys His Gln Tyr Leu 465 470 475 480 Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg 485 490 495 Lys Ala Ala Gln Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Pro 500 505 510 Tyr Lys Ala Val Asn Glu Phe Tyr Met Leu Gly Ser Tyr Arg Ala Asp 515 520 525 Glu Lys Gly Phe Pro Ala Glu Glu Tyr Trp Lys Asp Arg Glu Glu Tyr 530 535 540 Leu Leu Asn Arg Glu Leu Trp Glu Lys Lys Gln Glu Thr Ala Tyr Asn 545 550 555 560 Leu Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr 565 570 575 Ala Ala Leu Val Asp Lys Leu Arg Glu Ser Tyr Ala Gln Phe Ile Gln 580 585 590 Asp Ser Val Gly Leu Pro Gly Ala Asn Phe Asn Val Phe Gln Arg Pro 595 600 605 Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Tyr Arg 610 615 620 Ala Glu Lys Pro His Lys Thr His Leu Gly Asp Gly Leu Met Ala Pro 625 630 635 640 Ser His Glu Met Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg 645 650 655 Cys Tyr Pro Thr Tyr Ile Gly Val Leu Arg Glu Pro Leu Tyr Val Tyr 660 665 670 Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp 675 680 685 Gly Pro Pro Leu Asn Pro Tyr Glu Arg Ala Leu Ala Val Lys Lys Trp 690 695 700 Glu Asp Ala Leu Gln Asp Thr Asp Thr Glu Ile Asp Tyr Phe Asn Lys 705 710 715 720 Ile Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Pro Ala 725 730 735 Asn Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg 740 745 750 Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val 755 760 765 Asp Leu Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Ile Leu Pro 770 775 780 Asp Glu Arg Thr Ala Val Phe Pro Glu Trp Arg Cys Val Ala Arg Glu 785 790 795 800 Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Glu Lys 805 810 815 Asn Gln Thr Leu Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr 820 825 830 Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp 835 840 845 Gln Met Asp Pro Ser Thr Ile Lys Ser Ile Ala Ala Gly His Val Asn 850 855 860 Ile Lys Ser Thr Ser Phe Val Glu Thr Asp Asn Leu Ser Ala Glu Ile 865 870 875 880 Met Pro Ala Phe Glu Arg Ala Tyr Ser Pro Glu Gln Leu Ala Leu Val 885 890 895 His Ser Asp Ala Glu Glu Ser Asp Gly Glu Ser Gly His Ala Pro Phe 900 905 910 Tyr Thr Pro Trp Gly Gly Ala Gly His Val Thr Tyr Thr Tyr Lys Pro 915 920 925 Ile Thr Phe Val Asp Ala Glu Glu Asp Asp Leu Cys Leu His Thr Leu 930 935 940 Glu Lys Val Asp Pro Leu Ile Glu Asn Asp Arg Tyr Pro Ser Gln Ile 945 950 955 960 Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser 965 970 975 Gln Phe Leu Tyr Ala Glu Asp Leu Gly Thr Pro Leu Glu Asp Arg Pro 980 985 990 Leu Lys Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Ala 995 1000 1005 Gly His Arg Leu Met Glu Thr Gln Gly Lys Lys Arg Ile Lys Lys 1010 1015 1020 Asn Gly Gly Asn Leu Val Phe Asp Pro Ala Lys Pro Glu Leu Thr 1025 1030 1035 Trp Leu Val Glu Cys Glu Thr Val Cys Ala Gln Cys Gly Ala Asp 1040 1045 1050 Ala Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala 1055 1060 1065 Leu Lys Cys Leu His Cys Thr Lys Cys Gln His Val Ser Lys Gly 1070 1075 1080 Lys Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Ser Tyr Asp 1085 1090 1095 Leu Met Leu Arg Cys Tyr Leu Ala Asp Ser Gln Gly Asp Asp Ala 1100 1105 1110 Arg Phe Ser Thr Ser Arg Met Ser Leu Lys Arg Thr Leu Ala Ser 1115 1120 1125 Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu 1130 1135 1140 Thr Arg Thr Leu Arg Pro Trp Lys Asp Arg Thr Leu Ala Ala Leu 1145 1150 1155 Asp Ala His Arg Leu Val Pro Tyr Ser Glu Ser Arg Pro Asn Pro 1160 1165 1170 Arg Asn Gln Glu Val Cys Trp Ile Glu Ile Pro 1175 1180 <210> 27 <211> 1169 <212> PRT <213> Simian adenovirus 3 <400> 27 Met Ala Leu Val Gln Asp His Gly Ser Gly Gly Leu His Ala Thr Pro 1 5 10 15 Pro Asp Pro Gly Arg Gln Ser Pro Gly Asp Ser Leu Cys Gln Ser Ala 20 25 30 Pro Arg Ala Ala Pro Ala Pro Ala Arg Ala Pro Arg Arg Arg Ala Ala 35 40 45 Ala Arg Leu Ala Arg Gly Ser Arg Ala Ala Ala Ala Ala Gly Ser Pro 50 55 60 Ser Pro Pro Pro Ile Lys Thr Pro Arg Gly Thr Leu Val Ala Pro Arg 65 70 75 80 Pro His Gly His Leu Phe Ala Leu Asp Ala Arg Asp Arg His Pro Trp 85 90 95 Glu Ile Lys Tyr His Leu His Leu Leu Pro Ala Leu Thr His Leu Leu 100 105 110 Glu Val His Arg Leu Pro Pro Leu Pro Asp Asn Phe Arg Val His Asp 115 120 125 Ser Pro Ser Asp Glu Thr Leu Arg Glu Leu Val Gln Glu Leu Lys Pro 130 135 140 Gln Leu Ala Glu Val Trp Ser Val Arg Gly Arg Gly Thr Val Glu Pro 145 150 155 160 Ser Ser Ile Leu Pro Ala Asp Ala Glu Val Ala Ala Arg Ser Phe Pro 165 170 175 Leu Arg Phe Leu Ala Leu Gly Pro Pro Gln Arg Arg Lys Ile His Leu 180 185 190 Ile His Ser Leu His Ser Val Ser Arg Cys Asp His Cys Gly Arg Phe 195 200 205 Tyr Lys Asn Gln His Glu Cys Ser Thr Arg Arg Arg Asp Phe Tyr Phe 210 215 220 His His Ile His Ala Gln Ser Ser Gln Trp Trp Gln Pro Ile Lys Phe 225 230 235 240 Phe Pro Leu Gly Ser His Pro Arg Thr Glu Arg Leu Phe Leu Thr Tyr 245 250 255 Asp Val Glu Thr Tyr Thr Trp Met Gly Ala Phe Gly Lys Gln Leu Val 260 265 270 Pro Phe Leu Leu Val Met Lys Ile Thr Gly Glu Pro Ser Leu Val Arg 275 280 285 Leu Ala Leu Asn Leu Ala Arg Glu Leu Gly Trp Asp Ala Trp Arg Glu 290 295 300 His Ala Asp Thr Phe Phe Cys Leu Asn Pro Gln Lys Gln Ala Ile Gly 305 310 315 320 Arg Lys Phe Arg Glu Phe Arg Asp Arg Leu Gln Leu Leu Leu Val Asp 325 330 335 His Ile Trp Gln Asp Phe Val Glu Arg Asn Pro Val Glu Asp Trp Ser 340 345 350 Arg Thr Glu His Gly Val Glu Pro Arg Glu Leu Thr Phe Gln Gln Leu 355 360 365 Glu Lys Cys Pro Leu Leu Arg Gly Ala Pro Arg Phe Ile Glu Phe Tyr 370 375 380 Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Leu Leu Ala Ala 385 390 395 400 Gln Val Ile Asn Asn Arg Ser Glu Val Pro Gly Pro Phe Arg Ile Ser 405 410 415 Arg Asn Phe Met Pro Arg Cys Gly Lys Ile Leu Phe Asn Asp Val Thr 420 425 430 Tyr Ser Leu Pro Asn Pro Lys His Lys Lys Arg Thr Asp Tyr Ser Asp 435 440 445 Trp Glu Arg Gly Met Cys Asp Asp Arg Asp Phe Lys Tyr Gln Phe Val 450 455 460 Lys Val Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg 465 470 475 480 Lys Ala Ala Leu Ala Tyr Ser Leu Pro Val Glu Lys Gly Cys Cys Pro 485 490 495 Tyr Gln Ala Val Asn Gln Phe Tyr Met Leu Gly Ser Tyr Arg Gly Asp 500 505 510 Glu Asp Gly Phe Pro Leu Gln Glu Tyr Trp Lys Asp Arg Glu Glu Tyr 515 520 525 Leu Phe Asn Arg Asp Leu Trp Lys Glu Lys Lys Glu Glu His Tyr Asp 530 535 540 Ile Val Arg Glu Thr Leu Asp Tyr Cys Ala Leu Asp Val Leu Val Thr 545 550 555 560 Ala Ser Leu Val Glu Lys Leu Gln Glu Ser Tyr Ala His Phe Ile Gly 565 570 575 Glu Ala Val Gly Leu Pro Asp Ala Arg Phe Asn Ile Phe Gln Arg Pro 580 585 590 Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Leu Phe Arg 595 600 605 Asp Glu Lys Pro Gln Arg Ala His Leu Ser Arg His Leu Leu Ala Pro 610 615 620 Ser His Glu Leu Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg 625 630 635 640 Cys Tyr Pro Thr Tyr Leu Gly Val Leu Glu Glu Pro Leu Tyr Val Tyr 645 650 655 Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp 660 665 670 Gly Ala Pro Leu Ser Pro Tyr Glu Arg Ala Leu Ala Val Arg Asp Trp 675 680 685 Glu Thr Ala Leu Arg Arg Pro Gly His Gln Ile Asp Tyr Phe Asp Lys 690 695 700 His Leu Leu Pro Ala Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu 705 710 715 720 Arg Leu Leu Asp Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg 725 730 735 Leu Cys Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile 740 745 750 Asp Val Ile Thr Leu His Asn Arg Gly Trp Ser Val Arg Leu Val Pro 755 760 765 Asp Glu Arg Thr Ala Val Phe Pro Gly Trp Lys Cys Val Ala Arg Glu 770 775 780 Tyr Val Gln Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Arg Glu Lys 785 790 795 800 Asn Gln Thr Gln Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr 805 810 815 Gly Ser Phe Ala Thr Lys Leu Asp Asn Arg Gln Ile Val Phe Ser Asp 820 825 830 Gln Met Gly Pro Glu His Leu Lys Gly Ile Ser Thr Gly Ala Leu Ala 835 840 845 Ile Lys Ser Ser Ser Tyr Ile Glu Thr Asp Asn Leu Ser Ala Gln Val 850 855 860 Met Pro Ala Phe Thr Arg Val Tyr Val Pro Gln Gln Leu Ala Phe Gly 865 870 875 880 Asp Ser Glu Pro Glu Glu Ser Asp Glu Glu Gly Gly Asn Ala Pro Phe 885 890 895 Tyr Thr Pro Ala Glu Gly Gln Asp His Val Thr Tyr Thr Tyr Lys Pro 900 905 910 Ile Thr Phe Leu Glu Ala Asp Glu Gly Asp Met Cys Leu His Thr Leu 915 920 925 Glu Lys Thr Asp Pro Leu Ile Asp Asn Asp Arg Tyr Pro Ser His Ile 930 935 940 Ala Ser Phe Val Leu Ala Trp Thr Arg Ala Phe Met Ser Glu Trp Cys 945 950 955 960 Glu Phe Leu Tyr Ala Glu Asp Arg Gly Thr Pro Leu Glu Glu Arg Ala 965 970 975 Leu Thr Ser Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Arg 980 985 990 Gly His Arg Leu Met Glu Thr Arg Gly Arg Lys Arg Ile Lys Lys Asn 995 1000 1005 Gly Gly Arg Leu Val Phe Asp Pro Lys Asp Pro Gln Leu Thr Trp 1010 1015 1020 Leu Val Glu Cys Glu Thr Val Cys Ser Asn Cys Gly Gly Asp Ala 1025 1030 1035 Tyr Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu 1040 1045 1050 Lys Cys Leu Leu Cys Ser Asn Cys Gly His Val Ser Lys Gly Lys 1055 1060 1065 Leu Arg Ala Lys Gly His Ala Ala Glu Ser Leu Asp Tyr Glu Leu 1070 1075 1080 Met Val Arg Cys Tyr Leu Ala Asp Leu Gln Gly Asp Glu Lys Gln 1085 1090 1095 Arg Phe Ala Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Ser 1100 1105 1110 Ala Gln Pro Gly Ala His Pro Phe Thr Val Thr Glu Thr Thr Leu 1115 1120 1125 Lys Arg Thr Leu Arg Pro Trp Arg Asp Arg Thr Met Ala Gln Leu 1130 1135 1140 Asp Ala His Arg Leu Ile Pro Tyr Ser Gln Ser Arg Pro Asn Pro 1145 1150 1155 Arg Asn Glu Glu Val Cys Trp Ile Glu Met Pro 1160 1165 <210> 28 <211> 1017 <212> PRT <213> Bovine adenovirus 2 <400> 28 Met Leu Glu Ala Leu Lys Pro Ala Glu Gly Ala Thr Phe Thr Tyr Ile 1 5 10 15 Lys Gly Arg Leu Ile Lys Gln Gln Ala Ala Val Glu Asn Pro Ile Leu 20 25 30 Pro Phe Pro Ile Phe Phe Leu Ile Lys Gln Asn Lys Val Phe Leu Ile 35 40 45 Lys Ser Phe Gln Ser Ser Gln Lys Cys Glu Phe Cys Gly Asp Phe Phe 50 55 60 Ala Asn Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His 65 70 75 80 His Ile Asn Phe Lys Ser Ser Glu Trp Trp Ser Gln Ile Ser Phe Gln 85 90 95 Pro Ile Gly Ser Cys Asp Asp Thr Lys Arg Phe Phe Leu Thr Tyr Asp 100 105 110 Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro 115 120 125 Phe Met Leu Val Phe His Leu Ser Gly Glu Leu Glu Leu Val Ser Leu 130 135 140 Ser Ala Asn Ile Ala Glu Gln Gln Arg Trp Leu Ala Trp Asp Thr Pro 145 150 155 160 His Thr Tyr Tyr Tyr Val Ser Pro Ile Lys Gly Glu Ile Gly Lys Ala 165 170 175 Phe Lys Asp Leu Arg Tyr Glu Ile Gln Lys Gln Val Thr Arg Leu Leu 180 185 190 Trp Asp Asn Phe Val Gly Glu Asn Pro Glu Leu Ala Glu Ile Gln Glu 195 200 205 Arg His His Val Asn His Ile Asp Asp Ile Thr Ala Glu Met His Lys 210 215 220 Ile Lys Thr Lys Gly Ser Pro Gln Phe Ile Glu Ile Tyr Val Ile Gly 225 230 235 240 His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile 245 250 255 His Asn Arg Thr Asp Val Leu Pro Ala Phe Lys Ile Asn Arg Asn Phe 260 265 270 Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Ser Phe Cys Leu 275 280 285 Pro Asn Pro Lys Tyr Glu Lys Arg Lys Asp Phe Ala Asp Trp Glu Cys 290 295 300 Gly Lys Leu Thr Ala Ala Asp His Lys Tyr Gln Phe Val Lys Phe Met 305 310 315 320 Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala 325 330 335 Gly Ala Tyr Glu Leu Pro Val Glu Lys Gly Ser Cys Pro Tyr Glu Ala 340 345 350 Val Asn Glu Phe Tyr Arg Ile Gly Ser Tyr Gln Gln Asp Glu Asp Gly 355 360 365 Phe Pro Ser Leu Arg Tyr Trp Lys Ser Ser Glu Glu Tyr Gln Leu Asn 370 375 380 Lys Ala Leu Trp Arg Glu Lys Asn Val Gly Ala Tyr Asp Ile Ile Gln 385 390 395 400 Gln Thr Leu His Tyr Cys Val Gln Asp Val Leu Val Thr Ser Ala Leu 405 410 415 Val Asn Lys Leu Gln Glu Ser Tyr Lys Asn Phe Ile Ala Ser Gln Val 420 425 430 Asn Leu Pro Asp Ala Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser 435 440 445 Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Glu Val Arg 450 455 460 Pro Asn Lys Ala Asn Leu Asp Asn Val Leu Leu Ala Pro Ser His Glu 465 470 475 480 Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro 485 490 495 Thr Tyr Ile Gly Ile Met Glu Gln Pro Ile Tyr Val Tyr Asp Ile Cys 500 505 510 Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro Ser Gly Gln Pro 515 520 525 Leu Asn Pro Tyr Glu Arg Ala Leu Ala Ala Thr Glu Trp Ile Arg Lys 530 535 540 Leu Glu Asn Leu Glu Gln Lys Ile Asp Tyr Phe Asp Glu Cys Leu Leu 545 550 555 560 Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Leu Phe Leu 565 570 575 Asp Glu Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp 580 585 590 Ala Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile Asp Leu Ile 595 600 605 Thr Leu His Asn Arg Gly Trp Ala Val Arg Ile Leu Pro Asp Glu Arg 610 615 620 Thr Thr Ile Phe Pro Glu Trp Lys Cys Val Ala Lys Glu Tyr Val Gln 625 630 635 640 Leu Asn Ile Gly Ala Lys Glu Lys Ala Asp Lys Glu Lys Asn Gln Thr 645 650 655 Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe 660 665 670 Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu Glu 675 680 685 Ala Ser Ala Ser Lys Thr Ile Ala Arg Gly Asn Phe Ser Ile Lys Ser 690 695 700 Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Glu Ile Met Pro Glu 705 710 715 720 Phe Val Val Thr Tyr Pro Pro Ala Pro Ser Ala Glu Leu Asp Glu Ser 725 730 735 Asp Glu Asn Glu Glu His Thr Leu Phe Ile Pro Lys Asp Ser His Val 740 745 750 Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Glu Thr Glu Asp Asp Asp 755 760 765 Ile Cys Leu His Thr Leu Glu Asn Asn Ser Pro Leu Ile Glu Asn Asn 770 775 780 Arg Tyr Ala Ser His Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Val 785 790 795 800 Phe Val Ser Glu Trp Ala Glu Phe Leu Tyr Ala Glu Asp Arg Gly Lys 805 810 815 Pro Leu His Gln Arg Thr Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser 820 825 830 Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Glu Gln Arg Gly Lys 835 840 845 His Arg Ile Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Lys Asn 850 855 860 Pro Ser Ile Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys 865 870 875 880 Lys Ser Asp Ala Phe Ser Ser Glu Ser Val Phe Leu Ala Pro Lys Leu 885 890 895 Tyr Ala Leu Lys Asn Thr Val Cys Thr Cys Cys Gly His Val Gly Lys 900 905 910 Gly Lys Leu Arg Ala Lys Gly His Ala Thr Thr Glu Leu Cys Tyr Asp 915 920 925 Thr Leu Ala Lys Cys Tyr Leu Ser Asp Ala Gln Gln Gly Ser Gln Arg 930 935 940 Phe His Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Thr Asn Gln 945 950 955 960 Ser Asn Ala Ala Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr 965 970 975 Val Arg Pro Trp Lys Asp Lys Thr Leu Val Asp Ile Asp Gly His Arg 980 985 990 Leu Met Pro Tyr Ser Lys Ser Asn Pro Asn Pro Arg Asn Asn Asp Val 995 1000 1005 Cys Trp Met Thr Leu Pro Trp Asn Met 1010 1015 <210> 29 <211> 1017 <212> PRT <213> Ovine adenovirus A <400> 29 Met Leu Glu Ala Leu Lys Pro Ala Glu Gly Ala Thr Phe Thr Tyr Ile 1 5 10 15 Lys Gly Arg Leu Ile Lys Gln Gln Ala Ala Val Glu Asn Pro Ile Leu 20 25 30 Pro Phe Pro Ile Phe Phe Leu Ile Lys Gln Asn Lys Val Phe Leu Ile 35 40 45 Lys Ser Phe Gln Ser Ser Gln Lys Cys Glu Phe Cys Gly Asp Phe Phe 50 55 60 Ala Asn Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His 65 70 75 80 His Ile Asn Phe Lys Ser Ser Glu Trp Trp Ser Gln Ile Ser Phe Gln 85 90 95 Pro Ile Gly Ser Cys Asp Asp Thr Lys Arg Phe Phe Leu Thr Tyr Asp 100 105 110 Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro 115 120 125 Phe Met Leu Val Phe His Leu Ser Gly Glu Leu Glu Leu Val Ser Leu 130 135 140 Ser Ala Asn Ile Ala Glu Gln Gln Arg Trp Leu Ala Trp Asp Thr Pro 145 150 155 160 His Thr Tyr Tyr Tyr Val Ser Pro Ile Lys Gly Glu Ile Gly Lys Ala 165 170 175 Phe Lys Asp Leu Arg Tyr Glu Ile Gln Lys Gln Val Thr Arg Leu Leu 180 185 190 Trp Asp Asn Phe Val Gly Glu Asn Pro Glu Leu Ala Glu Ile Gln Glu 195 200 205 Arg His His Val Asn His Ile Asp Asp Ile Thr Ala Glu Met His Lys 210 215 220 Ile Lys Thr Lys Gly Ser Pro Gln Phe Ile Glu Ile Tyr Val Ile Gly 225 230 235 240 His Asn Ile Cys Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile 245 250 255 His Asn Arg Thr Asp Val Leu Pro Ala Phe Lys Ile Asn Arg Asn Phe 260 265 270 Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Ser Phe Cys Leu 275 280 285 Pro Asn Pro Lys Tyr Glu Lys Arg Lys Asp Phe Ala Asp Trp Glu Cys 290 295 300 Gly Lys Leu Thr Ala Ala Asp His Lys Tyr Gln Phe Val Lys Phe Met 305 310 315 320 Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Asn Ala Ala 325 330 335 Gly Ala Tyr Glu Leu Pro Val Glu Lys Gly Ser Cys Pro Tyr Glu Ala 340 345 350 Val Asn Glu Phe Tyr Arg Ile Gly Ser Tyr Gln Gln Asp Glu Asp Gly 355 360 365 Phe Pro Ser Leu Arg Tyr Trp Lys Ser Ser Glu Glu Tyr Gln Leu Asn 370 375 380 Lys Ala Leu Trp Arg Glu Lys Asn Val Gly Ala Tyr Asp Ile Ile Gln 385 390 395 400 Gln Thr Leu His Tyr Cys Val Gln Asp Val Leu Val Thr Ser Ala Leu 405 410 415 Val Asn Lys Leu Gln Glu Ser Tyr Lys Asn Phe Ile Ala Ser Gln Val 420 425 430 Asn Leu Pro Asp Ala Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile Ser 435 440 445 Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Glu Val Arg 450 455 460 Pro Asn Lys Ala Asn Leu Asp Asn Val Leu Leu Ala Pro Ser His Glu 465 470 475 480 Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr Pro 485 490 495 Thr Tyr Ile Gly Ile Met Glu Gln Pro Ile Tyr Val Tyr Asp Ile Cys 500 505 510 Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro Ser Gly Gln Pro 515 520 525 Leu Asn Pro Tyr Glu Arg Ala Leu Ala Ala Thr Glu Trp Ile Arg Lys 530 535 540 Leu Glu Asn Leu Glu Gln Lys Ile Asp Tyr Phe Asp Glu Cys Leu Leu 545 550 555 560 Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Leu Phe Leu 565 570 575 Asp Glu Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp 580 585 590 Ala Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Ile Asp Leu Ile 595 600 605 Thr Leu His Asn Arg Gly Trp Ala Val Arg Ile Leu Pro Asp Glu Arg 610 615 620 Thr Thr Ile Phe Pro Glu Trp Lys Cys Val Ala Lys Glu Tyr Val Gln 625 630 635 640 Leu Asn Ile Gly Ala Lys Glu Lys Ala Asp Lys Glu Lys Asn Gln Thr 645 650 655 Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe 660 665 670 Ala Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu Glu 675 680 685 Ala Ser Ala Ser Lys Thr Ile Ala Arg Gly Asn Phe Ser Ile Lys Ser 690 695 700 Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Glu Ile Met Pro Glu 705 710 715 720 Phe Val Val Thr Tyr Pro Pro Ala Pro Ser Ala Glu Leu Asp Glu Ser 725 730 735 Asp Glu Asn Glu Glu His Thr Leu Phe Ile Pro Lys Asp Ser His Val 740 745 750 Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Glu Thr Glu Asp Asp Asp 755 760 765 Ile Cys Leu His Thr Leu Glu Asn Asn Ser Pro Leu Ile Glu Asn Asn 770 775 780 Arg Tyr Ala Ser His Ile Ala Ser Phe Val Leu Ala Trp Thr Arg Val 785 790 795 800 Phe Val Ser Glu Trp Ala Glu Phe Leu Tyr Ala Glu Asp Arg Gly Lys 805 810 815 Pro Leu His Gln Arg Thr Ile Lys Ser Val Tyr Gly Asp Thr Asp Ser 820 825 830 Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Glu Gln Arg Gly Lys 835 840 845 His Arg Ile Lys Lys Asn Gly Gly Lys Leu Val Phe Asp Pro Lys Asn 850 855 860 Pro Ser Ile Thr Trp Leu Val Glu Cys Glu Thr Gln Cys Glu Lys Cys 865 870 875 880 Lys Ser Asp Ala Phe Ser Ser Glu Ser Val Phe Leu Ala Pro Lys Leu 885 890 895 Tyr Ala Leu Lys Asn Thr Val Cys Thr Cys Cys Gly His Val Gly Lys 900 905 910 Gly Lys Leu Arg Ala Lys Gly His Ala Thr Thr Glu Leu Cys Tyr Asp 915 920 925 Thr Leu Ala Lys Cys Tyr Leu Ser Asp Ala Gln Gln Gly Ser Gln Arg 930 935 940 Phe His Thr Ser Arg Leu Ser Leu Lys Arg Thr Leu Ala Thr Asn Gln 945 950 955 960 Ser Asn Ala Ala Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr 965 970 975 Val Arg Pro Trp Lys Asp Lys Thr Leu Val Asp Ile Asp Gly His Arg 980 985 990 Leu Met Pro Tyr Ser Lys Ser Asn Pro Asn Pro Arg Asn Asn Asp Val 995 1000 1005 Cys Trp Met Thr Leu Pro Trp Asn Met 1010 1015 <210> 30 <211> 1130 <212> PRT <213> Porcine adenovirus C <400> 30 Met Ser Val Val Pro Ser Asp Gly Ser Gly Arg Leu Leu Gly Ala Glu 1 5 10 15 Gly His Pro Lys His Gln Gln Lys Gly Arg Gly His Gly Asp Glu Ala 20 25 30 Glu Thr Gly Arg Gln Thr Tyr Ala Gly Thr Ala Arg Gly Arg Pro Ala 35 40 45 Arg Ser Gly Pro Val Arg Gly Asn Leu Val Ala Lys Arg Ala Thr Leu 50 55 60 Ser Ala Ser Gly Thr Leu Glu Asp Gly Thr His Val Asp Ile Lys Phe 65 70 75 80 His Ser Lys Thr Leu Glu Ala Leu Glu Asn Leu Phe His Leu His Leu 85 90 95 Leu Gln Leu Pro Pro Leu Pro Pro Ile Ser Thr Ser Asn Val Ser Asp 100 105 110 Val Leu Gln Leu Leu Ala Pro Arg Glu Gly Ser Val Val Val Tyr Asn 115 120 125 Arg Gly Arg Val Ser Val Lys Gln Val Glu Ile Arg Glu Pro Lys Ala 130 135 140 His Phe Asp Ile Gln Phe Leu Leu Lys Gln Gly Lys Val Tyr Leu Ile 145 150 155 160 Lys Glu Ile Gln Asp Thr Gln Lys Cys Glu Tyr Cys Gly Asp Phe Phe 165 170 175 Lys Thr Ser His Thr Cys Ser Val Arg Arg Arg Asp Phe Tyr Phe His 180 185 190 His Val His His Lys Ser Ser Asp Trp Trp Glu Asn Ile Pro Phe Gln 195 200 205 Pro Leu Gly Ser Tyr Arg Glu Thr Glu Arg Leu Tyr Ile Thr Tyr Asp 210 215 220 Val Glu Thr Tyr Thr Trp His Gly Lys His Gly Lys Gln Leu Val Pro 225 230 235 240 Phe Leu Leu Val Phe His Ile Ser Gly Glu Pro His Leu Val Lys Val 245 250 255 Ala Glu Ser Val Ala Gln Asp Leu Asn Trp Cys Pro Trp Thr Glu Lys 260 265 270 His Thr Phe Tyr Tyr Leu Asn Pro Gln Lys Ser Ala Val Gly Arg Met 275 280 285 Phe Lys Ser Phe Arg Asp Glu Leu Gln Asn Arg Val Thr Gln Asp Leu 290 295 300 Trp Lys Thr Phe Leu Ser Gln Asn Pro His Leu Val Glu Thr Ala Ala 305 310 315 320 Arg Leu Asn Leu Gly Ser Val Asp Asp Ile Thr Pro Glu Val Leu Lys 325 330 335 Lys Glu Lys Ile Cys Gly Glu Pro Arg Phe Ile Glu Val Tyr Val Ile 340 345 350 Gly His Asn Ile Ser Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val 355 360 365 Ile Cys His Gln Ser Lys Thr Ile Lys Ala Phe Lys Ile Ser Arg Asn 370 375 380 Phe Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile Thr Phe Gly 385 390 395 400 Leu Pro Asn Pro Leu Phe Glu Lys Arg Lys Glu Phe Gln Glu Trp Glu 405 410 415 Arg Gly Ser Met Ala Val Gln Asp Met Lys Gln Gln Phe Val Lys Leu 420 425 430 Met Val Arg Asp Thr Leu Met Leu Thr His Thr Ser Leu Arg Asn Ala 435 440 445 Ala Lys Ala Tyr Asp Leu Pro Val Glu Lys Gly Cys Cys Pro Tyr Glu 450 455 460 Ala Val Asn Glu Phe Tyr Arg Thr Gly Thr Tyr Gln Lys Asp Glu Asp 465 470 475 480 Gly Phe Pro Ser Leu Arg Tyr Trp Lys Asp Gln Glu Glu Tyr Ala Leu 485 490 495 Asn Lys Glu Leu Trp Arg Glu Lys Lys Cys Gly Ala Tyr Asp Leu Ile 500 505 510 Ser Ser Thr Leu Thr Tyr Cys Ala Gln Asp Val Leu Val Thr Ser Ser 515 520 525 Leu Val Arg Lys Leu Gln Glu Ser Tyr Gln Ser Phe Ile Ala Asn Glu 530 535 540 Val Asn Leu Pro Asp Ser Ser Phe Asn Ile Phe Gln Arg Pro Thr Ile 545 550 555 560 Ser Ser Asn Ser His Ala Ile Phe Lys Gln Ile Leu Tyr Arg Ala Glu 565 570 575 Lys Pro Glu Arg Gln His Leu Gly Glu Val Leu Leu Ala Pro Ser Asn 580 585 590 Glu Met Tyr Asp Tyr Val Arg Gln Ser Ile Arg Gly Gly Arg Cys Tyr 595 600 605 Pro Thr Tyr Ile Gly Ile Leu His Glu Pro Ile Tyr Val Tyr Asp Ile 610 615 620 Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Ser Gly Ser 625 630 635 640 Pro Leu Asn Pro Phe Glu Arg Ala Leu Ala Val Ala Val Trp Glu Asp 645 650 655 Gln Leu Lys Ser Val Gly Gln Lys Met Asp Tyr Phe Asp Glu Lys Leu 660 665 670 Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Asp Glu Ser Phe 675 680 685 Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys 690 695 700 Trp Thr Asn Glu Pro Leu Arg Gly Glu Val Ala Thr Ser Val Asp Val 705 710 715 720 Ile Thr Leu His Asn Arg Gly Trp Arg Val Arg Leu Val Pro Asp Glu 725 730 735 Arg Thr Thr Ile Phe Pro Glu Trp Lys Cys Leu Ala Lys Glu Tyr Val 740 745 750 Gln Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Arg Glu Lys Asn Gln 755 760 765 Thr Met Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser 770 775 780 Phe Ala Thr Arg Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Leu 785 790 795 800 Glu Glu Glu Ser Ser Lys Asn Ile Ser Arg Gly Lys Tyr Ser Val Lys 805 810 815 Ser Ser Ser Phe Ile Glu Thr Asp Asn Phe Ser Ala Asp Ile Met Pro 820 825 830 Glu Phe Val Val Ala Tyr Pro Pro Val Ala Asp Val Ser Asn Glu Asp 835 840 845 Asn Glu Ala Ala Glu Glu Ala Thr Pro Phe Ile Gly Lys Ser Asp His 850 855 860 Val Thr Tyr Lys Tyr Lys Pro Ile Thr Phe Leu Asp Val Glu Asp Asp 865 870 875 880 Asp Val Cys Leu His Thr Leu Glu Ser Ser Ser Ser Leu Val Leu Asn 885 890 895 Asn Arg Tyr Ala Ser His Leu Ala Ser Phe Val Leu Ala Trp Ala Arg 900 905 910 Val Phe Val Ser Glu Trp Ser Glu Phe Leu Tyr Glu Asn Asp Arg Gly 915 920 925 Val Pro Met Glu Glu Arg Gln Ile Lys Ser Val Tyr Gly Asp Thr Asp 930 935 940 Ser Leu Phe Val Thr Glu Glu Gly His Arg Leu Met Lys Glu Lys Gly 945 950 955 960 Lys His Arg Ile Lys Lys Asn Gly Gly Ser Leu Val Phe Asp Pro Gln 965 970 975 His Pro Gln Val Thr Trp Leu Val Glu Cys Glu Thr Arg Cys Asp Lys 980 985 990 Cys Gly Glu Asp Ala Tyr Ser Pro Thr Ser Val Phe Leu Ala Pro Lys 995 1000 1005 Leu Tyr Ala Leu Lys Ser Thr Val Cys Ser Val Cys Gly Tyr Val 1010 1015 1020 Gly Lys Gly Lys Leu Arg Ala Lys Gly His Ala Thr Ser Glu Leu 1025 1030 1035 Ser Phe Asp Val Leu Gln Arg Cys Tyr Leu Glu Asp Leu Gln Leu 1040 1045 1050 Gly Ser Glu Lys Phe Lys Thr Ser Arg Leu Ser Leu Lys Arg Thr 1055 1060 1065 Leu Ala Ser Cys Gln Ser Asn Ala Ala Pro Phe Thr Val Thr Glu 1070 1075 1080 Ala Thr Leu Thr Arg Thr Leu Arg Pro Trp Lys Asp Lys Thr Leu 1085 1090 1095 Thr Gln Ile Asp Gln Asn Arg Leu Ile Pro Tyr Ser Thr Ser Arg 1100 1105 1110 Pro Asn Pro Arg Asn Thr Asp Leu Cys Trp Met Thr Leu Pro Trp 1115 1120 1125 Asp Ser 1130 <210> 31 <211> 1136 <212> PRT <213> Tree shrew adenovirus <400> 31 Met Ala Leu Val Gln Ser Asp Arg Pro Arg Ser Leu Gln Pro Glu Ser 1 5 10 15 Gly Asn Ser Lys His Gln Pro Glu Ser Arg Arg Leu Arg Val Ser Ser 20 25 30 Glu Ala Ala Thr Pro Ala Ser Ser Gly Pro Gln Pro Ser Arg Ser Ser 35 40 45 Ala Pro Ala Leu Thr Arg Tyr Lys Gly Thr Val Val Ala Lys Arg Ala 50 55 60 Thr Cys Val Ile Asn Ala Thr Asp Glu Glu Gly Cys Phe Val Glu Ile 65 70 75 80 Lys Tyr His Val Asp Thr Asp Lys Ser Leu Gln Ala Leu Phe Asp Val 85 90 95 His Leu Ser Glu Arg Pro Glu Glu Ala Gly Asn Phe Thr Ala His Asn 100 105 110 Val Val Ala Lys Leu Glu Ala Ile Arg Pro Ser Gln Ala Ser Ile Val 115 120 125 Lys Tyr Phe Arg Gly Lys Ile Lys Thr Thr His Val Ala Ile Glu Asn 130 135 140 Pro Arg Phe Ser Phe Pro Ile Arg Phe Leu Ile Lys Asn His Gln Leu 145 150 155 160 Phe Leu Ile Lys Glu Ile Cys Thr Thr Met Lys Cys Glu His Cys Gly 165 170 175 Arg Tyr Phe Lys Gly Thr His Thr Cys Ser Ala Arg Arg Arg Asp Phe 180 185 190 Tyr Phe His His Ile Asn Ala Gln Ser Ser Ser Trp Trp Glu Pro Ile 195 200 205 Ser Phe Phe Pro Leu Gly Ala Pro Pro Glu Thr Lys Arg Leu Tyr Ile 210 215 220 Thr Tyr Asp Val Glu Thr Tyr Thr Trp His Gly Lys Phe Gly Lys Gln 225 230 235 240 Leu Val Pro Phe Met Leu Val Leu His Leu Ser Gly Asp Asp Glu Leu 245 250 255 Leu Ala Asp Ala Ile Thr Leu Ile Arg Gln Thr Ser Tyr Ile Pro Trp 260 265 270 Pro Lys His Asp Asn Thr Phe Tyr Tyr Leu Asn Pro Thr Lys Lys Thr 275 280 285 Val Gly Gln Leu Phe Lys Ser Leu Arg Asn Thr Leu Gln Thr His Phe 290 295 300 Ala Lys Lys Leu Trp Gln Leu Phe Leu Asp Gln Asn Pro Lys Ile Thr 305 310 315 320 Glu Tyr Cys Gln Leu Lys Gln Leu Asp Pro Asp Gln Leu Thr Ala Asp 325 330 335 Glu Leu Lys Asn Met Lys Ile Val Gly Thr Pro Ser Phe Trp Glu Val 340 345 350 Tyr Val Val Gly His Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala 355 360 365 Ala Gln Ile Ile Ser Asn Lys Ser Asp Val Pro Ala Ser Phe His Ile 370 375 380 Thr Arg Asn Phe Met Pro Arg Asn Gly Lys Ile Leu Phe Asn Asp Ile 385 390 395 400 Thr Phe Gly Leu Pro Asn Pro Ala Ser Lys Lys Arg Gln Asp Phe Thr 405 410 415 Leu Trp Glu Gln Gly Gly Cys Glu Ala Ser Asp Phe Lys Trp Gln Tyr 420 425 430 Val Lys Phe Met Val Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu 435 440 445 Arg Lys Ala Ala Ala Ala Tyr Ala Leu Asp Val Glu Lys Gly Ser Cys 450 455 460 Pro Tyr Lys Ala Val Asn Glu Phe Tyr Met Phe Gly Ser Tyr Gln Val 465 470 475 480 Asp Glu Val Gly Phe Pro Asp Glu His Tyr Trp Ser Ser Arg Glu Glu 485 490 495 Tyr Leu Phe Asn Arg Glu Glu Trp Leu Lys Lys Lys Glu His Ala Tyr 500 505 510 Asp Ile Ile Thr Gln Thr Leu Glu Tyr Cys Val Met Asp Val Val Val 515 520 525 Thr Ala Lys Leu Val Gln Lys Leu Gln Thr Ser Tyr Ala Ala Phe Val 530 535 540 Gln Glu Ser Val Asn Leu Pro Glu Ser Ser Phe Asn Val Phe Gln Arg 545 550 555 560 Pro Thr Ile Ser Ser Asn Ser His Ala Ile Phe Arg Gln Ile Val Tyr 565 570 575 Arg Ala Glu Lys Pro Gln Lys Thr His Leu Gly Gln Cys Leu Leu Ala 580 585 590 Pro Ser Asn Glu Met Tyr Asp Tyr Val Arg Ser Ser Ile Arg Gly Gly 595 600 605 Arg Cys Tyr Pro Ser Tyr Ile Gly Leu Leu Ser Glu Pro Ile Tyr Val 610 615 620 Tyr Asp Ile Cys Gly Met Tyr Ala Ser Ala Leu Thr His Pro Phe Pro 625 630 635 640 Ser Gly Arg Pro Leu Asn Pro Phe Asp Arg Ala Leu Ala Val Lys Asn 645 650 655 Trp Glu Met Arg Leu Lys Asn Ser Gln Thr Ile Asp Tyr Phe Thr Pro 660 665 670 His Leu Leu Pro Gly Ile Phe Thr Ile Asp Ala Asp Pro Pro Ser Glu 675 680 685 Thr Tyr Leu Asp Val Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg 690 695 700 Leu Cys Trp Thr Asn Glu Ser Leu Arg Gly Glu Val Ala Thr Ser Val 705 710 715 720 Asp Ile Ile Thr Leu His Asn Arg Gly Trp Lys Val Arg Ile Val Thr 725 730 735 Asp Glu Arg Thr Thr Val Phe Pro Glu Trp Lys Cys Ile Ala Gln Glu 740 745 750 Tyr Val Lys Leu Asn Ile Ala Ala Lys Glu Lys Ala Asp Lys Glu Lys 755 760 765 Asn Gln Thr Ile Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr 770 775 780 Gly Ser Phe Ala Thr Lys Leu Asp Asn Lys Lys Thr Val Phe Ala Asp 785 790 795 800 Gln Leu Asp Ser Ser Thr Ala Lys Gly Ile Ala Asn Gly Glu Phe Ser 805 810 815 Val Lys Ser Ser Ser Phe Ile Glu Thr Asp Cys Leu Ser Ala Glu Ile 820 825 830 Met Ser Glu Leu Val Val Ala Tyr Ser Pro Asp Thr Leu Leu His Pro 835 840 845 Gln Gln Glu Gly Ala Thr Glu Ala Asn Thr Gln Glu Thr Pro Thr Phe 850 855 860 Ile Gly Pro Thr Asp His Val Thr Tyr Thr Tyr Lys Pro Ile Thr Phe 865 870 875 880 Leu Glu Ala Glu Glu Asp Glu Ile Cys Leu Gln Thr Ile Glu Lys Asn 885 890 895 Ser Pro Leu Ile Pro Asn Asp Arg Tyr Pro Ser His Ile Ala Ser Phe 900 905 910 Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ala Ser Phe Leu 915 920 925 Tyr Ser Glu Asp Leu Gly Thr Pro Met Glu Arg Arg Cys Leu Lys Ser 930 935 940 Val Tyr Gly Asp Thr Asp Ser Leu Phe Leu Thr Glu Glu Gly Arg Arg 945 950 955 960 Leu Met Glu Thr Lys Gly Lys His Arg Ile Lys Lys Asn Gly Gly Lys 965 970 975 Leu Val Phe Asp Pro Ala Asn Pro Asp Leu Thr Trp Leu Val Glu Cys 980 985 990 Glu Thr Gln Cys Glu Lys Cys Gly Ala Asp Ala Phe Ser Ser Gln Ser 995 1000 1005 Ile Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys Asp Thr Thr Cys 1010 1015 1020 Pro Val Cys Lys His Val Gly Lys Gly Lys Leu Arg Ala Lys Gly 1025 1030 1035 His Ala Thr Asp Gly Leu Ser Phe Glu Ile Met Ser Lys Cys Tyr 1040 1045 1050 Phe Ala Asp Ser Gln Leu Gly Ser Asp Lys Phe Gln Thr Ser Arg 1055 1060 1065 Met Ser Ile Lys Arg Thr Leu Ala Ser Gly Gln Ser His Val Gln 1070 1075 1080 Pro Phe Thr Val Thr Glu Thr Thr Leu Thr Arg Thr Leu Arg Pro 1085 1090 1095 Trp Lys Asp Lys Thr Met Thr Ala Leu Asp Gln His Arg Leu Ile 1100 1105 1110 Pro Tyr Ser Asn Ser Cys Pro Asn Pro Arg Asn Asn Glu Val Cys 1115 1120 1125 Trp Ile Glu Met Ser Glu Thr Met 1130 1135 <210> 32 <211> 1198 <212> PRT <213> Human adenovirus 5 <400> 32 Met Ala Leu Val Gln Ala His Arg Ala Arg Arg Leu His Ala Glu Ala 1 5 10 15 Pro Asp Ser Gly Asp Gln Pro Pro Arg Arg Arg Val Arg Gln Gln Pro 20 25 30 Thr Arg Ala Ala Pro Ala Pro Ala Arg Ala Arg Arg Arg Arg Ala Pro 35 40 45 Ala Pro Ser Pro Gly Gly Ser Gly Ala Pro Pro Thr Ser Gly Gly Ser 50 55 60 Pro Ala Ser Pro Leu Leu Asp Ala Ser Ser Lys Asp Thr Pro Ala Ala 65 70 75 80 His Arg Pro Pro Arg Gly Thr Val Val Ala Pro Arg Gly Cys Gly Leu 85 90 95 Leu Gln Ala Ile Asp Ala Ala Thr Asn Gln Pro Leu Glu Ile Arg Tyr 100 105 110 His Leu Asp Leu Ala Arg Ala Leu Thr Arg Leu Cys Glu Val Asn Leu 115 120 125 Gln Glu Leu Pro Pro Asp Leu Thr Pro Arg Glu Leu Gln Thr Met Asp 130 135 140 Ser Ser His Leu Arg Asp Val Val Ile Lys Leu Arg Pro Pro Arg Ala 145 150 155 160 Asp Ile Trp Thr Leu Gly Ser Arg Gly Val Val Val Arg Ser Thr Val 165 170 175 Thr Pro Leu Glu Gln Pro Asp Gly Gln Gly Gln Ala Ala Glu Val Glu 180 185 190 Asp His Gln Pro Asn Pro Pro Gly Glu Gly Leu Lys Phe Pro Leu Cys 195 200 205 Phe Leu Val Arg Gly Arg Gln Val Asn Leu Val Gln Asp Val Gln Pro 210 215 220 Val His Arg Cys Gln Tyr Cys Ala Arg Phe Tyr Lys Ser Gln His Glu 225 230 235 240 Cys Ser Ala Arg Arg Arg Asp Phe Tyr Phe His His Ile Asn Ser His 245 250 255 Ser Ser Asn Trp Trp Arg Glu Ile Gln Phe Phe Pro Ile Gly Ser His 260 265 270 Pro Arg Thr Glu Arg Leu Phe Val Thr Tyr Asp Val Glu Thr Tyr Thr 275 280 285 Trp Met Gly Ala Phe Gly Lys Gln Leu Val Pro Phe Met Leu Val Met 290 295 300 Lys Phe Gly Gly Asp Glu Pro Leu Val Thr Ala Ala Arg Asp Leu Ala 305 310 315 320 Ala Asn Leu Gly Trp Asp Arg Trp Glu Gln Asp Pro Leu Thr Phe Tyr 325 330 335 Cys Ile Thr Pro Glu Lys Met Ala Ile Gly Arg Gln Phe Arg Thr Phe 340 345 350 Arg Asp His Leu Gln Met Leu Met Ala Arg Asp Leu Trp Ser Ser Phe 355 360 365 Val Ala Ser Asn Pro His Leu Ala Asp Trp Ala Leu Ser Glu His Gly 370 375 380 Leu Ser Ser Pro Glu Glu Leu Thr Tyr Glu Glu Leu Lys Lys Leu Pro 385 390 395 400 Ser Ile Lys Gly Ile Pro Arg Phe Leu Glu Leu Tyr Ile Val Gly His 405 410 415 Asn Ile Asn Gly Phe Asp Glu Ile Val Leu Ala Ala Gln Val Ile Asn 420 425 430 Asn Arg Ser Glu Val Pro Gly Pro Phe Arg Ile Thr Arg Asn Phe Met 435 440 445 Pro Arg Ala Gly Lys Ile Leu Phe Asn Asp Val Thr Phe Ala Leu Pro 450 455 460 Asn Pro Arg Ser Lys Lys Arg Thr Asp Phe Leu Leu Trp Glu Gln Gly 465 470 475 480 Gly Cys Asp Asp Thr Asp Phe Lys Tyr Gln Tyr Leu Lys Val Met Val 485 490 495 Arg Asp Thr Phe Ala Leu Thr His Thr Ser Leu Arg Lys Ala Ala Gln 500 505 510 Ala Tyr Ala Leu Pro Val Glu Lys Gly Cys Cys Ala Tyr Gln Ala Val 515 520 525 Asn Gln Phe Tyr Met Leu Gly Ser Tyr Arg Ser Glu Ala Asp Gly Phe 530 535 540 Pro Ile Gln Glu Tyr Trp Lys Asp Arg Glu Glu Phe Val Leu Asn Arg 545 550 555 560 Glu Leu Trp Lys Lys Lys Gly Gln Asp Lys Tyr Asp Ile Ile Lys Glu 565 570 575 Thr Leu Asp Tyr Cys Ala Leu Asp Val Gln Val Thr Ala Glu Leu Val 580 585 590 Asn Lys Leu Arg Asp Ser Tyr Ala Ser Phe Val Arg Asp Ala Val Gly 595 600 605 Leu Thr Asp Ala Ser Phe Asn Val Phe Gln Arg Pro Thr Ile Ser Ser 610 615 620 Asn Ser His Ala Ile Phe Arg Gln Ile Val Phe Arg Ala Glu Gln Pro 625 630 635 640 Ala Arg Ser Asn Leu Gly Pro Asp Leu Leu Ala Pro Ser His Glu Leu 645 650 655 Tyr Asp Tyr Val Arg Ala Ser Ile Arg Gly Gly Arg Cys Tyr Pro Thr 660 665 670 Tyr Leu Gly Ile Leu Arg Glu Pro Leu Tyr Val Tyr Asp Ile Cys Gly 675 680 685 Met Tyr Ala Ser Ala Leu Thr His Pro Met Pro Trp Gly Pro Pro Leu 690 695 700 Asn Pro Tyr Glu Arg Ala Leu Ala Ala Arg Ala Trp Gln Gln Ala Leu 705 710 715 720 Asp Leu Gln Gly Cys Lys Ile Asp Tyr Phe Asp Ala Arg Leu Leu Pro 725 730 735 Gly Val Phe Thr Val Asp Ala Asp Pro Pro Asp Glu Thr Gln Leu Asp 740 745 750 Pro Leu Pro Pro Phe Cys Ser Arg Lys Gly Gly Arg Leu Cys Trp Thr 755 760 765 Asn Glu Arg Leu Arg Gly Glu Val Ala Thr Ser Val Asp Leu Val Thr 770 775 780 Leu His Asn Arg Gly Trp Arg Val His Leu Val Pro Asp Glu Arg Thr 785 790 795 800 Thr Val Phe Pro Glu Trp Arg Cys Val Ala Arg Glu Tyr Val Gln Leu 805 810 815 Asn Ile Ala Ala Lys Glu Arg Ala Asp Arg Asp Lys Asn Gln Thr Leu 820 825 830 Arg Ser Ile Ala Lys Leu Leu Ser Asn Ala Leu Tyr Gly Ser Phe Ala 835 840 845 Thr Lys Leu Asp Asn Lys Lys Ile Val Phe Ser Asp Gln Met Asp Ala 850 855 860 Ala Thr Leu Lys Gly Ile Thr Ala Gly Gln Val Asn Ile Lys Ser Ser 865 870 875 880 Ser Phe Leu Glu Thr Asp Asn Leu Ser Ala Glu Val Met Pro Ala Phe 885 890 895 Gln Arg Glu Tyr Ser Pro Gln Gln Leu Ala Leu Ala Asp Ser Asp Ala 900 905 910 Glu Glu Ser Glu Asp Glu Arg Ala Pro Thr Pro Phe Tyr Ser Pro Pro 915 920 925 Ser Gly Thr Pro Gly His Val Ala Tyr Thr Tyr Lys Pro Ile Thr Phe 930 935 940 Leu Asp Ala Glu Glu Gly Asp Met Cys Leu His Thr Leu Glu Arg Val 945 950 955 960 Asp Pro Leu Val Asp Asn Asp Arg Tyr Pro Ser His Leu Ala Ser Phe 965 970 975 Val Leu Ala Trp Thr Arg Ala Phe Val Ser Glu Trp Ser Glu Phe Leu 980 985 990 Tyr Glu Glu Asp Arg Gly Thr Pro Leu Glu Asp Arg Pro Leu Lys Ser 995 1000 1005 Val Tyr Gly Asp Thr Asp Ser Leu Phe Val Thr Glu Arg Gly His 1010 1015 1020 Arg Leu Met Glu Thr Arg Gly Lys Lys Arg Ile Lys Lys His Gly 1025 1030 1035 Gly Asn Leu Val Phe Asp Pro Glu Arg Pro Glu Leu Thr Trp Leu 1040 1045 1050 Val Glu Cys Glu Thr Val Cys Gly Ala Cys Gly Ala Asp Ala Tyr 1055 1060 1065 Ser Pro Glu Ser Val Phe Leu Ala Pro Lys Leu Tyr Ala Leu Lys 1070 1075 1080 Ser Leu His Cys Pro Ser Cys Gly Ala Ser Ser Lys Gly Lys Leu 1085 1090 1095 Arg Ala Lys Gly His Ala Ala Glu Gly Leu Asp Tyr Asp Thr Met 1100 1105 1110 Val Lys Cys Tyr Leu Ala Asp Ala Gln Gly Glu Asp Arg Gln Arg 1115 1120 1125 Phe Ser Thr Ser Arg Thr Ser Leu Lys Arg Thr Leu Ala Ser Ala 1130 1135 1140 Gln Pro Gly Ala His Pro Phe Thr Val Thr Gln Thr Thr Leu Thr 1145 1150 1155 Arg Thr Leu Arg Pro Trp Lys Asp Met Thr Leu Ala Arg Leu Asp 1160 1165 1170 Glu His Arg Leu Leu Pro Tyr Ser Glu Ser Arg Pro Asn Pro Arg 1175 1180 1185 Asn Glu Glu Ile Cys Trp Ile Glu Met Pro 1190 1195 <210> 33 <211> 911 <212> PRT <213> Bovine adenovirus 3 <400> 33 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Ser Tyr Phe Asn Ile Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Ala Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Phe Ala Pro Lys Ser 115 120 125 Ala Pro Asn Asn Thr Gln Phe Arg Gln Ala Asn Asn Gly His Pro Ala 130 135 140 Gln Thr Ile Ala Gln Ala Ser Tyr Val Ala Thr Ile Gly Gly Ala Asn 145 150 155 160 Asn Asp Leu Gln Met Gly Val Asp Glu Arg Gln Leu Pro Val Tyr Ala 165 170 175 Asn Thr Thr Tyr Gln Pro Glu Pro Gln Leu Gly Ile Glu Gly Trp Thr 180 185 190 Ala Gly Ser Met Ala Val Ile Asp Gln Ala Gly Gly Arg Val Leu Arg 195 200 205 Asn Pro Thr Gln Thr Pro Cys Tyr Gly Ser Tyr Ala Lys Pro Thr Asn 210 215 220 Glu His Gly Gly Ile Thr Lys Ala Asn Thr Gln Val Glu Lys Lys Tyr 225 230 235 240 Tyr Arg Thr Gly Asp Asn Gly Asn Pro Glu Thr Val Phe Tyr Thr Glu 245 250 255 Glu Ala Asp Val Leu Thr Pro Asp Thr His Leu Val His Ala Val Pro 260 265 270 Ala Ala Asp Arg Ala Lys Val Glu Gly Leu Ser Gln His Ala Ala Pro 275 280 285 Asn Arg Pro Asn Phe Ile Gly Phe Arg Asp Cys Phe Val Gly Leu Met 290 295 300 Tyr Tyr Asn Ser Gly Gly Asn Leu Gly Val Leu Ala Gly Gln Ser Ser 305 310 315 320 Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser 325 330 335 Tyr Gln Met Leu Leu Ala Asn Thr Thr Asp Arg Ser Arg Tyr Phe Ser 340 345 350 Met Trp Asn Gln Ala Met Asp Ser Tyr Asp Pro Glu Val Arg Val Ile 355 360 365 Asp Asn Val Gly Val Glu Asp Glu Met Pro Asn Tyr Cys Phe Pro Leu 370 375 380 Ser Gly Val Gln Ile Gly Asn Arg Ser His Glu Val Gln Arg Asn Gln 385 390 395 400 Gln Gln Trp Gln Asn Val Ala Asn Ser Asp Asn Asn Tyr Ile Gly Lys 405 410 415 Gly Asn Leu Pro Ala Met Glu Ile Asn Leu Ala Ala Asn Leu Trp Arg 420 425 430 Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Asn Leu Lys 435 440 445 Phe Thr Pro His Asn Ile Gln Leu Pro Pro Asn Thr Asn Thr Tyr Glu 450 455 460 Tyr Met Asn Gly Arg Ile Pro Val Ser Gly Leu Ile Asp Thr Tyr Val 465 470 475 480 Asn Ile Gly Thr Arg Trp Ser Pro Asp Val Met Asp Asn Val Asn Pro 485 490 495 Phe Asn His His Arg Asn Ser Gly Leu Arg Tyr Arg Ser Gln Leu Leu 500 505 510 Gly Asn Gly Arg Phe Cys Asp Phe His Ile Gln Val Pro Gln Lys Phe 515 520 525 Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu 530 535 540 Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly 545 550 555 560 Asn Asp Leu Arg Val Asp Gly Ala Thr Val Asn Ile Thr Ser Val Asn 565 570 575 Leu Tyr Ala Ser Phe Phe Pro Met Ser His Asn Thr Ala Ser Thr Leu 580 585 590 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr 595 600 605 Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro Asn Ala Thr Gln 610 615 620 Leu Pro Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Leu 625 630 635 640 Thr Arg Leu Lys Gln Arg Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp 645 650 655 Pro Tyr Phe Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe 660 665 670 Tyr Leu Ser His Thr Phe Arg Lys Val Ala Ile Gln Phe Asp Ser Ser 675 680 685 Val Thr Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu 690 695 700 Ile Lys Ile Ser Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn 705 710 715 720 Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile 725 730 735 Gly Tyr Gln Gly Tyr His Leu Pro Pro Asp Tyr Lys Asp Arg Thr Phe 740 745 750 Ser Phe Leu His Asn Phe Ile Pro Met Cys Arg Gln Val Pro Asn Pro 755 760 765 Ala Thr Glu Gly Tyr Phe Gly Leu Gly Ile Val Asn His Arg Thr Thr 770 775 780 Pro Ala Tyr Trp Phe Arg Phe Cys Arg Ala Pro Arg Glu Gly His Pro 785 790 795 800 Tyr Pro Gln Leu Ala Leu Pro Pro His Trp Asp Pro Arg His Ala Leu 805 810 815 Arg Asp Pro Glu Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile 820 825 830 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly 835 840 845 Gln Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe 850 855 860 Glu Met Asp Pro Ile Asn Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu 865 870 875 880 Val Phe Asp Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu 885 890 895 Val Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 910 <210> 34 <211> 917 <212> PRT <213> Ovine adenovirus 6 <400> 34 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Ser Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Ser His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr 65 70 75 80 Lys Thr Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Ile Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ser 115 120 125 Cys Pro Asn Asn Thr Gln Phe Ala Pro Ala Gln Asn Gly Tyr Pro His 130 135 140 Arg Val Ile Ala Gln Ala Ser Tyr Ala Gly Ala Ile Glu Gly Gln Asn 145 150 155 160 Asp Glu Leu Arg Val Gly Ala Asn Glu Arg Gly Gln Pro Val Tyr Ala 165 170 175 Asp Ala Arg Tyr Gln Pro Glu Pro Gln Ile Gly Val Glu Gly Trp Thr 180 185 190 Ala Gly Thr Leu Ala Thr Ile Asn Gln Ala Gly Ala Arg Val Leu Arg 195 200 205 Asn Thr Pro Ala Arg Pro Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn 210 215 220 Pro Glu Gly Gly Gln Ala Arg Val Gly Thr Gln Val Gln Lys Asp Tyr 225 230 235 240 Tyr Arg Val Asp Ala Asn Gly Asn Gly Asn Pro Asn Ala Val Leu Tyr 245 250 255 Ser Glu Glu Val Asp Leu Lys Thr Pro Asp Thr His Leu Leu His Ala 260 265 270 Thr Glu Val Pro Ala Asn Gly Ala Val Thr Val Asp Ala Leu Ser Gln 275 280 285 Leu Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Cys Phe 290 295 300 Ile Gly Leu Met Tyr Tyr Asn Ser Gly Gly Asn Leu Gly Val Leu Ala 305 310 315 320 Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn 325 330 335 Thr Glu Leu Ser Tyr Gln Met Leu Leu Ala Asn Thr Thr Asp Arg Ser 340 345 350 Arg Tyr Phe Ser Met Trp Asn Gln Ala Met Asp Thr Tyr Asp Pro Glu 355 360 365 Val Arg Val Ile Asp Asn Ile Gly Val Glu Asp Glu Met Pro Asn Tyr 370 375 380 Cys Phe Pro Met Ser Gly Val Ala Phe Gly Ala Pro Met Thr Lys Val 385 390 395 400 Gln Lys Asn Gln Asn Ala Trp Gln Ala Val Ala Asn Gly Gly Asn Met 405 410 415 Tyr Val Ser Arg Gly Asn Leu Gly Ala Met Glu Ile Asn Leu Ser Ala 420 425 430 Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro 435 440 445 Asp Asp Gln Lys Tyr Thr Pro Thr Asn Val Arg Leu Pro Ala Asn Thr 450 455 460 Asn Thr Tyr Glu Tyr Met Asn Gly Arg Lys Pro Leu Gln Gly Phe Leu 465 470 475 480 Asp Ser Tyr Val Asn Ile Gly Thr Arg Trp Ser Pro Asp Ala Met Asp 485 490 495 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg 500 505 510 Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Asp Phe His Ile Gln Val 515 520 525 Pro Gln Lys Phe Phe Ala Val Arg Asn Leu Leu Leu Leu Pro Gly Thr 530 535 540 Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln 545 550 555 560 Ser Thr Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Asn Ile 565 570 575 Thr Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ser His Asn Thr 580 585 590 Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser 595 600 605 Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro 610 615 620 Asn Ala Thr Gln Leu Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 625 630 635 640 Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Gln Arg Glu Thr Pro Ala 645 650 655 Leu Gly Ser Ala Phe Asp Pro Tyr Phe Thr Tyr Ser Gly Thr Ile Pro 660 665 670 Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Arg Arg Val Ala 675 680 685 Ile Gln Phe Asp Ser Ser Val Thr Trp Pro Gly Asn Asp Arg Leu Leu 690 695 700 Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr 705 710 715 720 Thr Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 725 730 735 Leu Ala His Tyr Asn Met Gly Phe Gln Gly Tyr Gln Leu Pro Pro Asp 740 745 750 Tyr Lys Asp Arg Thr Phe Ser Phe Leu His Asn Phe Thr Pro Met Cys 755 760 765 Arg Gln Val Pro Asn Pro Ala Asn Glu Gly His Gln Gln Leu Arg Ile 770 775 780 Thr Arg Leu His Asn Asn Ser Gly Phe Ile Gly Phe Asp Thr Gly Ala 785 790 795 800 Gly Ser Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro Tyr Pro Leu 805 810 815 Ile Gly Pro Asp Ala Val Pro Ser Val Thr Gln Arg Lys Phe Leu Cys 820 825 830 Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met 835 840 845 Gly Ser Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ala Ala 850 855 860 His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Ile Asn Glu Pro Thr 865 870 875 880 Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg Val His Gln 885 890 895 Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr Pro Phe Ser 900 905 910 Ala Gly Asn Ala Thr 915 <210> 35 <211> 911 <212> PRT <213> Tree shrew adenovirus <400> 35 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Phe Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Ser Tyr Phe Asn Ile Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser 115 120 125 Ala Thr Asn Asn Ala Gln Tyr Thr Ser Gly Gly Lys Thr Ala Thr Tyr 130 135 140 Ala Gln Ala Ser Phe Ile Ser Glu Ile Val Glu Val Gly Gly Gln Tyr 145 150 155 160 Gly Ile Lys Val Gly Glu Asp Asn Thr Gly Ala Asp Ile Leu Ala Asp 165 170 175 Pro Asn Tyr Gln Pro Glu Pro Thr Val Gly Gly Glu Gly Trp Thr Val 180 185 190 Glu Leu Gly Thr Ile Asp Ser Ala Gly Gly Arg Val Leu Ser Ala Thr 195 200 205 Thr Pro Lys Ala Pro Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn Asn 210 215 220 Asn Gly Gly Gln Thr Thr Gly Gln Val Asn Val Lys Phe Phe Lys Glu 225 230 235 240 Gly Gln Gly Ala Gly Asn Pro Thr Val Ala Leu Tyr Ser Glu Thr Val 245 250 255 Asp Met Gln Ser Pro Asp Thr His Leu Val Tyr Ala Thr Glu Pro Gly 260 265 270 Ala Leu Pro Asp Gly Leu Gly Gln Gln Ser Ala Pro Asn Arg Pro Asn 275 280 285 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser 290 295 300 Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala 305 310 315 320 Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met 325 330 335 Leu Asp Ser Leu Val Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln 340 345 350 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Val Leu Glu Asn Asn Gly 355 360 365 Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Ser Gly Val Gly 370 375 380 Leu Thr Glu Leu Tyr Thr Gly Val Ala Arg Asn Gly Gly Asn Trp Ala 385 390 395 400 Ala Asp Asn Asp Ala Ala Ala Ser Gln Ile Ala Val Gly Asn Val His 405 410 415 Ala Met Glu Ile Asn Ile Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr 420 425 430 Ser Asn Val Ala Leu Tyr Leu Pro Asp Glu Tyr Lys Tyr Thr Pro Ile 435 440 445 Asn Val Thr Leu Pro Glu Asn Thr Asn Thr Tyr Ala Tyr Met Asn Gly 450 455 460 Arg Val Pro Ala Asn Asn Leu Val Asp Ser Phe Val Asn Val Gly Ala 465 470 475 480 Arg Trp Ser Pro Asp Val Met Asp Asn Val Asn Pro Phe Asn His His 485 490 495 Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg 500 505 510 Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 515 520 525 Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg 530 535 540 Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg 545 550 555 560 Val Asp Gly Ala Ser Ile Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser 565 570 575 Phe Phe Pro Met Ser His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu 580 585 590 Arg Asn Asp Thr Asn Asp Gln Cys Phe Thr Asp Tyr Leu Ser Ala Ala 595 600 605 Asn Met Leu Tyr Pro Ile Ala Ala Asn Ala Thr Asn Val Pro Ile Ser 610 615 620 Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg 625 630 635 640 Leu Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr 645 650 655 Phe Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu 660 665 670 Asn His Thr Phe Arg Arg Val Ala Ile Gln Phe Asp Ser Ser Val Ser 675 680 685 Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys 690 695 700 Arg Ala Val Asp Gly Glu Gly Tyr Ser Thr Ala Gln Ser Thr Ile Thr 705 710 715 720 Lys Asp Trp Phe Leu Thr Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr 725 730 735 Gln Gly Tyr Tyr Leu Pro Asp Gly Tyr Lys Asp Arg Leu Tyr Ser Phe 740 745 750 Leu Arg Asn Phe Gln Pro Met Cys Arg Gln Val Val Asp Glu Ala Asn 755 760 765 Tyr Ala Asn Tyr Lys Ala Val Ser Ile Thr His Gln His Asn Asn Ser 770 775 780 Gly Phe Thr Gly Phe Ala Ser Ala Ala Val Pro Arg Glu Gly His Pro 785 790 795 800 Tyr Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Asp Thr Ala Val Pro 805 810 815 Ser Val Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile 820 825 830 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Thr Leu Ser Asp Leu Gly 835 840 845 Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Ile Phe 850 855 860 Glu Val Asp Pro Met Pro Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu 865 870 875 880 Val Phe Asp Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu 885 890 895 Val Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 910 <210> 36 <211> 905 <212> PRT <213> Canine adenovirus 2 <400> 36 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Ala 115 120 125 Gly Ala Asn Asn Cys Leu Phe Asn Gly Gln Gly Ala Asn Ile Asn Thr 130 135 140 Leu Ala Gln Val Pro Ser Ala Gly Ala Ile Thr Val Asn Gly Gln Ala 145 150 155 160 Ala Val Thr Asn Asn Thr Tyr Gln Pro Glu Pro Gln Leu Gly Pro Glu 165 170 175 Ser Trp Val Asp Gly Ser Leu Ala Glu Leu Gly Asp Ala Ser Gly Arg 180 185 190 Ala Leu Lys Ala Ser Thr Pro Arg Met Pro Cys Tyr Gly Ser Tyr Ala 195 200 205 Pro Pro Thr Asn Glu Asn Gly Gly Gln Ala Thr Gly Pro Val Glu Ser 210 215 220 Arg Phe Tyr Lys Val Thr Thr Asn Asn Asn Asn Glu Ala Asp Ala Met 225 230 235 240 Leu Tyr Thr Glu Asp Val Asn Leu Gln Ala Pro Asp Thr His Leu Val 245 250 255 His Gln Val Pro Glu Gly Gln Val Thr Gly Val Gln Gly Leu Gly Gln 260 265 270 Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 275 280 285 Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala 290 295 300 Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn 305 310 315 320 Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg Ser 325 330 335 Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Gln Asp 340 345 350 Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn Tyr 355 360 365 Cys Tyr Pro Leu Ser Gly Met Gly Pro Leu Thr Asn Met Thr Thr Met 370 375 380 Lys Val Asn Asn Gln Asn Phe Gln Ala Glu Asn Thr Asn Val Gly Pro 385 390 395 400 Ile Gln Lys Ile Gly Phe Gly Asn Val Glu Ala Met Glu Ile Asn Leu 405 410 415 Asn Ala Asn Leu Phe Lys Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr 420 425 430 Leu Pro Asp Ala Phe Lys Tyr Thr Pro Glu Asn Ile Val Ala Pro Ala 435 440 445 Asn Val Asn Thr Tyr Ala Tyr Met Asn Val Arg Leu Pro Ala Ala Asn 450 455 460 Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val 465 470 475 480 Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 485 490 495 Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile 500 505 510 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 515 520 525 Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile 530 535 540 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Thr Ile 545 550 555 560 Asn Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His 565 570 575 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Val Asn Asp 580 585 590 Gln Ser Phe Ala Asp Tyr Leu Ser Ser Ala Asn Met Leu Tyr Pro Ile 595 600 605 Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala Arg Asn Trp 610 615 620 Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Arg Glu Thr 625 630 635 640 Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Ser 645 650 655 Ile Pro Tyr Leu Asp Ala Thr Phe Tyr Leu Ser His Thr Phe Arg Arg 660 665 670 Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 675 680 685 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Tyr Val Asp Gly Glu 690 695 700 Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Met Val 705 710 715 720 Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro 725 730 735 Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn Phe Glu Pro 740 745 750 Met Cys Arg Gln Leu Val Asp Val Ala Asn Tyr Ala Ala Tyr Gln Pro 755 760 765 Val Thr Val Gly His Gln His Asn Asn Ser Gly Tyr Ala Ser Ala Leu 770 775 780 Ser Ala Phe Asn Pro Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro 785 790 795 800 Tyr Pro Leu Ile Gly Ala Asn Ala Val Pro Thr Val Thr Gln Lys Lys 805 810 815 Phe Leu Cys Asp Arg Ser Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe 820 825 830 Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ser 835 840 845 Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met Asn 850 855 860 Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg 865 870 875 880 Val His Gln Pro His Arg Gly Val Ile Glu Val Gly Tyr Leu Arg Thr 885 890 895 Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 <210> 37 <211> 905 <212> PRT <213> Canine adenovirus 1 <400> 37 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Arg Ala 115 120 125 Gly Ala Asn Asn Cys Leu Phe Asn Gly Ser Gly Ala Asn Ile Asn Thr 130 135 140 Leu Ala Gln Val Pro Phe Ala Gly Ala Ile Thr Val Asn Gly Gln Ala 145 150 155 160 Ala Val Thr Asp Asn Thr Tyr Gln Pro Glu Pro Gln Leu Gly Pro Glu 165 170 175 Ser Trp Val Asp Gly Thr Leu Ala Asp Leu Gly Asp Ala Ser Gly Arg 180 185 190 Ala Leu Lys Ala Ser Thr Pro Arg Met Pro Cys Tyr Gly Ser Tyr Ala 195 200 205 Pro Pro Thr Asn Glu Asn Gly Gly Gln Ala Thr Gly Ala Val Glu Arg 210 215 220 Arg Phe Tyr Lys Val Thr Thr Asn Asn Asn Asn Glu Ala Asp Ala Leu 225 230 235 240 Leu Tyr Thr Glu Asp Val Asn Leu Gln Thr Pro Asp Thr His Leu Val 245 250 255 His Gln Val Ser Asp Asp Gln Val Thr Gly Val Gln Gly Leu Gly Gln 260 265 270 Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 275 280 285 Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala 290 295 300 Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn 305 310 315 320 Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg Ser 325 330 335 Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Gln Asp 340 345 350 Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn Tyr 355 360 365 Cys Phe Pro Leu Ser Gly Met Gly Pro Leu Thr Asn Met Thr Ala Met 370 375 380 Lys Val Asn Asn Gln Asn Phe Gln Thr Asp Asn Thr Asn Val Gly Pro 385 390 395 400 Ile Gln Lys Ile Gly Phe Gly Asn Val Glu Ala Met Glu Ile Asn Leu 405 410 415 Asn Ala Asn Leu Phe Lys Gly Phe Leu Tyr Ser Asn Val Ala Leu Tyr 420 425 430 Leu Pro Asp Ala Tyr Lys Tyr Thr Pro Asp Asn Ile Val Ala Pro Ala 435 440 445 Asn Ala Asn Thr Tyr Ala Tyr Met Asn Val Arg Leu Pro Ala Ala Asn 450 455 460 Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val 465 470 475 480 Met Asp Ser Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 485 490 495 Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile 500 505 510 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 515 520 525 Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile 530 535 540 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile 545 550 555 560 Asn Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His 565 570 575 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Val Asn Asp 580 585 590 Gln Ser Phe Ala Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile 595 600 605 Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala Arg Asn Trp 610 615 620 Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Arg Glu Thr 625 630 635 640 Pro Ala Leu Gly Ser Pro Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Ser 645 650 655 Ile Pro Tyr Leu Asp Ser Thr Phe Tyr Leu Ser His Thr Phe Arg Arg 660 665 670 Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 675 680 685 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Tyr Val Asp Gly Glu 690 695 700 Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val 705 710 715 720 Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro 725 730 735 Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn Phe Glu Pro 740 745 750 Met Cys Arg Gln Leu Val Asp Val Thr Asn Tyr Ala Thr Tyr Gln Ser 755 760 765 Val Thr Val Gly His Gln His Asn Asn Ser Gly Tyr Ala Ser Ala Leu 770 775 780 Ser Thr Phe Asn Pro Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro 785 790 795 800 Tyr Pro Leu Ile Gly Val Asn Ala Val Pro Thr Val Thr Gln Lys Lys 805 810 815 Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe 820 825 830 Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ser 835 840 845 Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met Asn 850 855 860 Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Ala Arg 865 870 875 880 Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr 885 890 895 Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 <210> 38 <211> 908 <212> PRT <213> Bat adenovirus TJM <400> 38 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ala Glu Tyr Leu Ser Pro Ala Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Ser Ser Tyr Phe Lys Leu Asp Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Tyr Val Pro Val Met Gln Glu Asp Gly Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ala 115 120 125 Gly Ala Asn Asn Cys Leu Phe Asn Gly Thr Gly Asn Asn Ile Asn Thr 130 135 140 Val Ala Gln Val Thr Thr Leu Gly Asn Ile Thr Val Gln Gly Leu Asn 145 150 155 160 Gly Val Thr Asn Ser Ala Tyr Glu Pro Tyr Pro Gln Gln Gly Pro Glu 165 170 175 Ser Trp Thr Ser Gly Ser Leu Glu Ala Ile Gly Asp Ala Gly Ala Arg 180 185 190 Ala Leu Lys Ala Thr Val Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala 195 200 205 Ala Pro Thr Asn Glu Asn Gly Gly Gln Ser Thr Gly Thr Ile Thr Pro 210 215 220 Ala Tyr Tyr Lys Lys Thr Thr Thr Ala Gly Ala Thr Asp Val Asp Ala 225 230 235 240 Met Leu Tyr Thr Glu Glu Val Ala Leu Gln Ala Pro Asp Thr His Leu 245 250 255 Val Tyr Lys Val Ala Glu Ala Asp Ala Lys Gly Ile Pro Gly Val Gly 260 265 270 Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn 275 280 285 Phe Val Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu 290 295 300 Ala Gly Gln Ser Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg 305 310 315 320 Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ala Leu Thr Asp Arg 325 330 335 Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp His 340 345 350 Asp Val Arg Ile Ile Asp Asn His Gly Val Glu Asp Asp Met Pro Asn 355 360 365 Tyr Cys Phe Pro Leu Ser Gly Met Gly Val Met Glu Ala Val Ser Ser 370 375 380 Met Lys Val Asn Thr Ala Asn Asn Gly Phe Glu Ala Asn Asn Thr Asn 385 390 395 400 Gln Gly Pro Val Gln Gln Ile Gly Phe Gly Asn Val Asn Ala Met Glu 405 410 415 Ile Asn Leu Asn Ala Asn Leu Phe Lys Gly Phe Leu Tyr Ser Asn Ile 420 425 430 Ala Leu Tyr Leu Pro Asp Asp Tyr Lys Tyr Thr Pro Gln Asn Val Thr 435 440 445 Glu Pro Ala Asn His Asn Thr Tyr Ala Tyr Met Asn Ile Arg Leu Pro 450 455 460 Ala Ala Asn Leu Val Asp Thr Phe Val Asn Val Gly Ala Arg Trp Ser 465 470 475 480 Pro Asp Val Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn Ala 485 490 495 Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser 500 505 510 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu 515 520 525 Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val 530 535 540 Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly 545 550 555 560 Ala Ser Ile Thr Ile Gln Ser Ile Asn Leu Tyr Ala Ser Phe Phe Pro 565 570 575 Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp 580 585 590 Val Asn Asp Gln Thr Phe Ala Asp Tyr Leu Ser Ala Ala Asn Met Leu 595 600 605 Tyr Pro Ile Pro Ala Asn Thr Thr Asn Leu Pro Ile Ser Ile Pro Ala 610 615 620 Arg Asn Trp Ala Gly Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln 625 630 635 640 Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr 645 650 655 Ser Gly Thr Met Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr 660 665 670 Phe Arg Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly 675 680 685 Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val 690 695 700 Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp 705 710 715 720 Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr 725 730 735 His Leu Pro Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Leu Arg Asn 740 745 750 Phe Glu Pro Met Cys Arg Gln Gln Val Asp Thr Gln Lys Ala Glu Asn 755 760 765 Tyr Gln Ala Val Thr Ile Asn Asn Gln His Asn Asn Ser Gly Tyr Ala 770 775 780 Ser Ala Leu Ser Ala Ser Asn Pro Arg Glu Gly His Pro Tyr Pro Ala 785 790 795 800 Asn Trp Pro Tyr Pro Leu Ile Gly Ala Thr Ala Leu Pro Ser Val Thr 805 810 815 Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser 820 825 830 Ser Asn Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu 835 840 845 Leu Tyr Ser Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp 850 855 860 Glu Met Asn Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp 865 870 875 880 Val Ala Arg Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr 885 890 895 Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 <210> 39 <211> 939 <212> PRT <213> Porcine adenovirus 3 <400> 39 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ser 20 25 30 Gln Ala Thr Glu Thr Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Phe Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ile Met Ala Pro Lys Ser 115 120 125 Ala Pro Asn Asn Cys Gln Tyr Leu Asp Pro Lys Gly Glu Thr Glu Ala 130 135 140 Gly Lys Val Asn Thr Ile Ala Gln Ala Ser Phe Val Gly Pro Ile Asp 145 150 155 160 Glu Thr Thr Gly Asp Ile Lys Ile Thr Glu Glu Glu Asp Glu Glu Thr 165 170 175 Thr Ile Asp Pro Leu Tyr Glu Pro Gln Pro Gln Leu Gly Pro Ser Ser 180 185 190 Trp Ser Asp Asn Ile Pro Ser Ala Thr Ser Gly Ala Gly Arg Val Leu 195 200 205 Lys Gln Thr Thr Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala Ser Pro 210 215 220 Thr Asn Ile His Gly Gly Gln Thr Lys Asp Asp Lys Val Thr Pro Leu 225 230 235 240 Tyr Phe Thr Asn Asn Pro Ala Thr Glu Ala Glu Ala Leu Glu Glu Asn 245 250 255 Gly Leu Lys Pro Asn Val Thr Leu Tyr Ser Glu Asp Val Asp Leu Lys 260 265 270 Ala Pro Asp Thr His Leu Val Tyr Ala Val Asn Gln Thr Gln Glu Phe 275 280 285 Ala Gln Tyr Gly Leu Gly Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr 290 295 300 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn 305 310 315 320 Gly Asn Gln Gly Met Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 325 330 335 Val Asp Leu Gln Asp Arg Asn His Arg Thr Ser Tyr Gln Leu Phe Leu 340 345 350 Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Gly 355 360 365 Ile Asp Ser Tyr Asp Lys Asp Val Arg Val Leu Gly Asn Asn Gly Val 370 375 380 Glu Asp Glu Met Pro Asn Phe Cys Phe Pro Ile Gly Ala Ile Glu Thr 385 390 395 400 Asn Met Thr Phe Thr Gln Leu Lys Lys Ser Glu Asn Gly Gly Ser Arg 405 410 415 Ala Thr Thr Trp Thr Lys Glu Asn Gly Asp Asp Gly Gly Asn Gly Ala 420 425 430 Glu His Tyr Leu Gly Ile Gly Asn Leu Asn Ala Met Glu Ile Asn Leu 435 440 445 Thr Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr 450 455 460 Leu Pro Asp Lys Tyr Lys Phe Ser Pro Pro Asn Val Pro Ile Asp Pro 465 470 475 480 Asn Thr His Ser Tyr Asp Tyr Ile Asn Lys Arg Leu Pro Leu Asn Asn 485 490 495 Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val 500 505 510 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly Leu Arg 515 520 525 Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile 530 535 540 Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Ser Leu Leu Leu Leu Pro 545 550 555 560 Gly Ala Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met 565 570 575 Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Lys 580 585 590 Ile Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala 595 600 605 His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn 610 615 620 Asn Gln Thr Phe Ile Asp Phe Leu Ser Ser Ala Asn Met Leu Tyr Pro 625 630 635 640 Ile Pro Ala Asn Val Thr Asn Leu Pro Ile Ser Ile Pro Ser Arg Asn 645 650 655 Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys His Asn Glu 660 665 670 Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr Ser Gly 675 680 685 Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Gly His Thr Phe Arg 690 695 700 Arg Ile Ser Ile Gln Phe Asp Ser Ser Val Ala Trp Pro Gly Asn Asp 705 710 715 720 Arg Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Thr Val Asp Gly 725 730 735 Glu Gly Tyr Thr Val Ala Gln Thr Asn Met Thr Lys Asp Trp Phe Leu 740 745 750 Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu 755 760 765 Pro Glu Gly Tyr Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Glu 770 775 780 Pro Met Cys Arg Gln Val Pro Asp Tyr Ala Asn His Lys Asp Glu Tyr 785 790 795 800 Leu Glu Val Pro Thr Thr Asn Gln Phe Asn Ser Ser Gly Phe Val Ser 805 810 815 Ala Ala Phe Thr Ala Gly Ile Ala Gln Gly His Pro Tyr Pro Ala Asn 820 825 830 Trp Pro Tyr Pro Leu Ile Gly Glu Asp Ala Val Gln Thr Val Thr Gln 835 840 845 Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser 850 855 860 Asn Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu 865 870 875 880 Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala 885 890 895 Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val 900 905 910 Cys Gly Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu 915 920 925 Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 <210> 40 <211> 938 <212> PRT <213> Porcine adenovirus 3 <400> 40 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ser 20 25 30 Gln Ala Thr Glu Thr Tyr Phe Asn Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Phe Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ile Met Ala Pro Lys Ser 115 120 125 Ala Pro Asn Asn Cys Gln Tyr Leu Asp Pro Lys Gly Glu Thr Glu Ala 130 135 140 Gly Lys Val Asn Thr Ile Ala Gln Ala Ser Phe Val Gly Pro Ile Asp 145 150 155 160 Glu Thr Thr Gly Asp Ile Lys Ile Thr Glu Glu Glu Asp Glu Glu Thr 165 170 175 Thr Ile Asp Pro Leu Tyr Glu Pro Gln Pro Gln Leu Gly Pro Ser Ser 180 185 190 Trp Ser Asp Asn Ile Pro Ser Ala Thr Ser Gly Ala Gly Arg Val Leu 195 200 205 Lys Gln Thr Thr Pro Arg Gln Pro Cys Tyr Gly Ser Tyr Ala Ser Pro 210 215 220 Thr Asn Ile His Gly Gly Gln Thr Lys Asp Asp Lys Val Thr Pro Leu 225 230 235 240 Tyr Phe Thr Asn Asn Pro Ala Thr Glu Ala Glu Ala Leu Glu Glu Asn 245 250 255 Gly Leu Lys Pro Asn Val Thr Leu Tyr Ser Glu Asp Val Asp Leu Lys 260 265 270 Ala Pro Asp Thr His Leu Val Tyr Ala Val Asn Gln Thr Gln Glu Phe 275 280 285 Ala Gln Tyr Gly Leu Gly Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr 290 295 300 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn 305 310 315 320 Gly Asn Gln Gly Met Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 325 330 335 Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Phe Leu 340 345 350 Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala 355 360 365 Ile Asp Ser Tyr Asp Lys Asp Val Arg Val Leu Glu Asn Asn Gly Val 370 375 380 Glu Asp Glu Met Pro Asn Phe Cys Phe Pro Ile Gly Ala Ile Glu Thr 385 390 395 400 Asn Met Thr Phe Thr Gln Leu Lys Lys Ser Glu Asn Gly Gly Ser Arg 405 410 415 Ala Thr Thr Trp Thr Lys Glu Asn Gly Asp Asp Gly Gly Asn Gly Ala 420 425 430 Glu His Tyr Leu Gly Ile Gly Asn Leu Asn Ala Met Glu Ile Asn Leu 435 440 445 Thr Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr 450 455 460 Leu Pro Asp Lys Tyr Lys Phe Ser Pro Pro Asn Val Pro Ile Asp Pro 465 470 475 480 Asn Thr His Ser Tyr Asp Tyr Ile Asn Lys Arg Leu Pro Leu Asn Asn 485 490 495 Leu Ile Asp Thr Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val 500 505 510 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly Leu Arg 515 520 525 Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile 530 535 540 Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Ser Leu Leu Leu Leu Pro 545 550 555 560 Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile 565 570 575 Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Lys Ile 580 585 590 Asn Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His 595 600 605 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asn 610 615 620 Gln Thr Phe Ile Asp Phe Leu Ser Ser Ala Asn Met Leu Tyr Pro Ile 625 630 635 640 Pro Ala Asn Val Thr Asn Leu Pro Ile Ser Ile Pro Ser Arg Asn Trp 645 650 655 Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys His Asn Glu Thr 660 665 670 Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr Tyr Ser Gly Ser 675 680 685 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Gly His Thr Phe Arg Arg 690 695 700 Ile Ser Ile Gln Phe Asp Ser Ser Val Ala Trp Pro Gly Asn Asp Arg 705 710 715 720 Leu Leu Thr Pro Asn Glu Phe Glu Val Lys Arg Thr Val Asp Gly Glu 725 730 735 Gly Tyr Thr Val Ala Gln Thr Asn Met Thr Lys Asp Trp Phe Leu Val 740 745 750 Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro 755 760 765 Glu Gly Tyr Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Glu Pro 770 775 780 Met Cys Arg Gln Val Pro Asp Tyr Ala Asn His Lys Asp Glu Tyr Leu 785 790 795 800 Glu Val Pro Thr Thr Asn Gln Phe Asn Ser Ser Gly Phe Val Ser Ala 805 810 815 Ala Phe Thr Ala Gly Met Arg Glu Gly His Pro Tyr Pro Ala Asn Trp 820 825 830 Pro Tyr Pro Leu Ile Gly Glu Asp Ala Val Gln Thr Val Thr Gln Arg 835 840 845 Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn 850 855 860 Phe Met Ser Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr 865 870 875 880 Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Met 885 890 895 Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Cys 900 905 910 Gly Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg 915 920 925 Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 <210> 41 <211> 914 <212> PRT <213> Bovine adenovirus 10 <400> 41 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Ala Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Ser Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Thr Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Val Ile Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Asn Leu Ala Pro Arg Ser 115 120 125 Ala Pro Asn Asn Cys Phe Phe Lys Asn Asp Asn Gly Gly His Pro Asp 130 135 140 Val Ala Tyr Ala Gln Leu Pro Phe Val Gly Thr Arg Glu Gln Gln Asn 145 150 155 160 Leu Met Val Leu Asn Ala Glu Gly Gln Arg Val Ala Ala Asp Pro Ile 165 170 175 Tyr Gln Pro Glu Pro Gln Tyr Gly Val Asp Ala Trp Pro Gln Asn Arg 180 185 190 Leu Gly Asp Phe Asn Ala Gly Arg Ala Leu Lys Ser Asp Val Thr His 195 200 205 Leu Pro Cys Tyr Gly Ser Tyr Ala Ser Pro Thr Asn Ile His Gly Gly 210 215 220 Gln Ser Thr Asp Asp Asp Ile Thr Lys Val Phe Phe Arg Arg Glu Asn 225 230 235 240 Ala Ala Gly Ala Pro Glu Gly Val Leu Tyr Ser Glu Thr Val Ala Leu 245 250 255 Glu Gln Pro Asp Thr His Leu Ser Phe Lys Val Thr Ala Asp Gln Thr 260 265 270 Thr Lys Leu Leu Gly Leu Ala Gln Gln Ala Cys Pro Asn Arg Pro Asn 275 280 285 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser 290 295 300 Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ser 305 310 315 320 Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met 325 330 335 Leu Asp Asn Leu Tyr Asp Arg Ser Thr Tyr Phe Ser Leu Trp Asn Gln 340 345 350 Ala Ile Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly 355 360 365 Val Glu Asp Glu Ile Pro Ala Phe Cys Phe Pro Ile Ser Ala Ile Gln 370 375 380 Thr Thr Val Phe Tyr Thr Gln Met Lys Thr Asp Asp Asn Gly Asn Asn 385 390 395 400 Trp Thr Pro Val Asp Asn Ala Thr Gln Asn Gln Tyr Val Asp Arg Gly 405 410 415 Asn Leu Gln Cys Met Glu Val Asn Ile Ser Gly Asn Leu Trp Arg Ser 420 425 430 Phe Leu Tyr Ser Asn Val Gly Leu Tyr Leu Pro Asp Arg Leu Lys Phe 435 440 445 Thr Pro Glu Asn Val Glu Glu Pro Glu Asn His Asp Thr Tyr Asp Tyr 450 455 460 Met Asn Ile Arg Ile Pro Pro Ser Gly Leu Val Glu Asn Tyr Ile Asn 465 470 475 480 Ile Gly Ala Arg Trp Ser Leu Asp Ile Met Asp Asn Val Asn Pro Phe 485 490 495 Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly 500 505 510 Asn Gly Arg Tyr Cys Glu Phe His Ile Gln Val Pro Gln Lys Phe Phe 515 520 525 Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr Glu Trp 530 535 540 Ser Phe Arg Lys Asp Val Asn Met Ile Phe Gln Ser Ser Leu Gly Asn 545 550 555 560 Asp Leu Arg Val Asp Gly Ala Lys Ile Thr Ile Glu Ser Val Asn Leu 565 570 575 Tyr Ala Ser Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu 580 585 590 Ala Met Leu Arg Asn Glu Thr Asn Asp Gln Thr Phe Asn Asp Tyr Leu 595 600 605 Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Pro Gln Thr Ser Asn Val 610 615 620 Pro Ile Thr Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser 625 630 635 640 Phe Thr Arg Leu Lys Ala Lys Glu Thr Pro Ala Leu Gly Ser Pro Tyr 645 650 655 Asp Pro Tyr Phe Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr 660 665 670 Phe Tyr Leu Asn His Thr Phe Arg Lys Val Ala Ile Gln Phe Asp Ser 675 680 685 Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Ser Pro Asn Glu Phe 690 695 700 Glu Ile Lys Arg Gln Val Asp Gly Glu Gly Tyr Asn Ile Ala Gln Ser 705 710 715 720 Asn Met Thr Lys Asp Trp Phe Leu Thr Gln Met Leu Cys His Tyr Asn 725 730 735 Ile Gly Tyr Gln Gly Tyr His Leu Pro Asp Ser Tyr Lys Asp Arg Thr 740 745 750 Tyr Ser Phe Leu Lys Asn Phe Gln Pro Met Cys Arg Gln Ile Val Thr 755 760 765 Ala Asn Thr Phe Asp Asn Tyr Lys Ala Val Thr Ile Ala Asn Gln His 770 775 780 Asn Asn Ser Gly Phe Ile Gly Phe Pro Asn Pro Val Ser Ala Arg Glu 785 790 795 800 Gly His Pro Tyr Pro Ala Asn Trp Pro Tyr Pro Ile Ile Gly Thr Thr 805 810 815 Ala His Arg Ala Glu Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu 820 825 830 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr 835 840 845 Asp Leu Gly Gln Asn Leu Leu Tyr Ser Asn Ser Ala His Ala Leu Asp 850 855 860 Met Thr Phe Glu Val Glu Pro Met Asp Glu Pro Thr Leu Leu Tyr Val 865 870 875 880 Leu Phe Glu Val Phe Asp Val Cys Arg Ile His Gln Pro His Arg Gly 885 890 895 Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ala Ala Gly Asn Ala 900 905 910 Thr Thr <210> 42 <211> 908 <212> PRT <213> Ovine adenovirus 1 <400> 42 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Ser Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ala 115 120 125 Ser Val Asn Asn Thr Phe Phe Thr Ala Ala Ala Asn Asn Asn Ala Gln 130 135 140 Ala Ile Ala Gln Ala Pro Phe Val Ala Glu Ile Val Ala Asn Thr Gly 145 150 155 160 Glu Ile Glu Ile Asp Gly Glu Pro Ile Asp Asn Thr Tyr Gln Pro Glu 165 170 175 Pro Gln Leu Gly Glu Glu Ser Trp Leu Ser Gly Thr Ile Asn Pro Ile 180 185 190 Asn Glu Ala Thr Gly Arg Ile Leu Asn Thr Asn Thr Asp Pro Leu Pro 195 200 205 Cys Tyr Gly Ser Tyr Ala Asn Pro Thr Asn Lys Asp Gly Gly Gln Ala 210 215 220 Thr Gly Asn Lys Leu Thr Val Asn Phe Lys Leu Gly Asn Gln Ala Gly 225 230 235 240 Asp Pro Asp Thr Ala Phe Ile Met Glu Asp Val Asn Leu Thr Ala Pro 245 250 255 Asp Ser His Leu Val Tyr Lys Val Pro Gln Asp Gln Ala Gly Lys Ile 260 265 270 Ala Ala Val Ala Gln Gln Ala Gly Pro Asn Arg Pro Asn Tyr Ile Gly 275 280 285 Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn 290 295 300 Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp 305 310 315 320 Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser 325 330 335 Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Ile Trp Asn Gln Ala Val Asp 340 345 350 Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp 355 360 365 Glu Met Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Phe Pro Gly Ser 370 375 380 Pro Ser Val Arg Val Thr Arg Gln Gln Asn Ala Trp Ala Lys Ala Pro 385 390 395 400 Gly Thr Glu Asp Asn Asn Tyr Ile Asn Lys Gly Asn Leu Glu Cys Met 405 410 415 Glu Ile Asn Leu Asn Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn 420 425 430 Val Ala Leu Tyr Leu Pro Asp Ala Leu Lys Phe Thr Pro Pro Asn Val 435 440 445 Thr Leu Pro Gln Asn Gln Asn Thr Tyr Ala Tyr Met Asn Gly Arg Ile 450 455 460 Pro Ala Gly Gly Leu Val Asp Thr Phe Val Asn Ile Gly Ala Arg Trp 465 470 475 480 Ser Leu Asp Val Met Asp Asn Ile Asn Pro Phe Asn His His Arg Asn 485 490 495 Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys 500 505 510 Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu 515 520 525 Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp 530 535 540 Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp 545 550 555 560 Gly Ala Ser Ile Thr Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe Phe 565 570 575 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 580 585 590 Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn Met 595 600 605 Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Leu Pro Ile Ser Ile Pro 610 615 620 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys 625 630 635 640 Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr 645 650 655 Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His 660 665 670 Thr Phe Arg Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp Pro 675 680 685 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Met 690 695 700 Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp 705 710 715 720 Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly 725 730 735 Tyr His Leu Pro Asp Ser Tyr Lys Asp Arg Thr Tyr Ser Phe Leu Arg 740 745 750 Asn Phe Glu Pro Met Ser Arg Gln Val Val Asp Ile Ala Asn Tyr Ala 755 760 765 Ala Tyr Gln Asp Val Pro Leu Thr His Gln His Asn Asn Ser Gly Phe 770 775 780 Thr Gly Phe Gly Ser Ala Ala Leu Pro Arg Glu Gly His Pro Tyr Pro 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Ile Gly Ala Asn Ala Ala Pro Thr Leu 805 810 815 Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe 820 825 830 Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn 835 840 845 Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val 850 855 860 Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe 865 870 875 880 Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val 885 890 895 Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr 900 905 <210> 43 <211> 908 <212> PRT <213> Bovine adenovirus 1 <400> 43 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr His 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ser Ile Asn Asn Thr Phe Val Ser Val Ala Gly Asn Asn Asn Ala Lys 130 135 140 Ala Phe Ala Gln Ala Pro Gln Ser Ala Thr Val Asp Gly Thr Thr Gly 145 150 155 160 Ala Ile Gln Ile Asp Gly Ala Ala Ile Asp Asn Thr Tyr Gln Pro Glu 165 170 175 Pro Gln Lys Gly Glu Glu Ser Trp Leu Ser Gly Thr Val Asn Pro Ile 180 185 190 Ala Gln Ala Thr Gly Arg Ile Leu Asn Thr Ser Thr Asp Pro Leu Pro 195 200 205 Cys Tyr Gly Ser Tyr Ala Ala Pro Thr Asn Ile Glu Gly Ala Gln Thr 210 215 220 Leu Asn Asn Asn Leu Ile Gln Val Asn Phe Val Ala Gly Gly Ala Pro 225 230 235 240 Gly Ala Pro Asp Val Gly Met Ile Met Glu Asp Val Ala Leu Gln Thr 245 250 255 Pro Asp Thr His Leu Val Tyr Lys Val Pro Ala Ala Asn Val Gly Asn 260 265 270 Thr Ala Ala Leu Ala Gln Gln Ala Ala Pro Asn Arg Ala Asn Tyr Ile 275 280 285 Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly 290 295 300 Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 305 310 315 320 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp 325 330 335 Asn Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Ile Trp Asn Gln Ala Val 340 345 350 Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu 355 360 365 Asp Glu Leu Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Val Pro Gly 370 375 380 Thr Thr Ser Thr Arg Val Thr Arg Asn Gly Gly Asn Trp Glu Ala Thr 385 390 395 400 Ala Asn Asn Asp Pro Ala Tyr Val Asn Lys Gly Asn Leu Asp Cys Met 405 410 415 Glu Ile Asn Leu Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn 420 425 430 Val Ala Leu Tyr Leu Pro Asp Asp Leu Lys Phe Thr Pro Pro Asn Val 435 440 445 Thr Leu Pro Asn Asn Thr Asn Thr Tyr Ala Tyr Met Asn Gly Arg Val 450 455 460 Pro Ala Ala Gly Leu Val Asp Thr Tyr Val Asn Ile Gly Ala Arg Trp 465 470 475 480 Ser Leu Asp Val Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 485 490 495 Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys 500 505 510 His Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu 515 520 525 Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp 530 535 540 Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp 545 550 555 560 Gly Ala Ser Ile Thr Ile Glu Ser Val Asn Leu Tyr Ala Ser Phe Phe 565 570 575 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 580 585 590 Asp Thr Asn Asp Gln Ser Phe Ile Asp Tyr Leu Ser Ser Ala Asn Met 595 600 605 Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Leu Pro Ile Ser Ile Pro 610 615 620 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys 625 630 635 640 Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe Thr 645 650 655 Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His 660 665 670 Thr Phe Arg Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp Pro 675 680 685 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Leu 690 695 700 Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp 705 710 715 720 Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly 725 730 735 Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu Arg 740 745 750 Asn Phe Gln Pro Met Thr Arg Gln Ile Val Asp Gln Thr Asn Val Pro 755 760 765 Ala Tyr Gln Asn Val Pro Ile Thr His Gln His Asn Asn Ser Gly Phe 770 775 780 Thr Gly Phe Ala Ser Pro Ala Leu Pro Arg Glu Gly His Pro Tyr Pro 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Ile Ser Ala Thr Ala Val Ala Thr Gln 805 810 815 Thr Gln Arg Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe 820 825 830 Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn 835 840 845 Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val 850 855 860 Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe 865 870 875 880 Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr Val 885 890 895 Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr 900 905 <210> 44 <211> 910 <212> PRT <213> Ovine adenovirus 2 <400> 44 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala 115 120 125 Ser Val Asn Asn Thr Leu Phe Ile Ala Thr Thr Gly Ala Lys Pro Gln 130 135 140 Ala Ile Ala Gln Ala Ser Phe Glu Ala Thr Val Asn Asp Asn Thr Gly 145 150 155 160 Ala Ile Glu Leu Asp Gly Gln Gln Ile Asn Leu Ser Tyr Gln Pro Ser 165 170 175 Pro Gln Leu Gly Glu Glu Ser Trp Leu Gly Asp Asp Phe Asn Pro Ile 180 185 190 Lys Glu Gly Thr Gly Arg Ile Leu Asp Val Asn Thr Lys Pro Leu Pro 195 200 205 Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Ile Asn Gly Gly Gln Gly 210 215 220 Leu Ala Glu Pro Thr Thr Ile Asn Phe Lys Thr Gly Asn Ala Pro Asp 225 230 235 240 Ile Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Ala Leu Gln Ala Pro 245 250 255 Asp Thr His Leu Val Tyr Lys Val Ala Asn Asp Lys Ser Gly Lys Thr 260 265 270 Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile Gly 275 280 285 Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly Asn 290 295 300 Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp 305 310 315 320 Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp Ser 325 330 335 Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile Asp 340 345 350 Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp 355 360 365 Glu Met Pro Asn Tyr Cys Phe Pro Ile Ser Gly Ile Lys Leu Glu Glu 370 375 380 Thr Ser Met Arg Val Val Arg Asn Pro Gly Asn Asn Gly Trp Ile Gly 385 390 395 400 Asp Asn Asp Ala Asn Gly Asn Asn Tyr Ile Asn Ile Gly Asn Met Asp 405 410 415 Cys Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr 420 425 430 Ser Asn Ile Ala Leu Tyr Leu Pro Asp Asp Tyr Lys Phe Thr Pro Ala 435 440 445 Asn Val Thr Leu Pro Glu Asn Thr Asn Thr Tyr Glu Tyr Leu Asn Gly 450 455 460 Arg Ile Pro Ala Gly Gly Leu Val Asp Thr Tyr Val Asn Ile Gly Ala 465 470 475 480 Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn Pro Phe Asn His His 485 490 495 Arg Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg 500 505 510 Tyr Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys 515 520 525 Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg 530 535 540 Lys Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg 545 550 555 560 Val Asp Gly Ala Ser Ile Thr Ile Asp Ser Val Asn Leu Tyr Ala Ser 565 570 575 Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu 580 585 590 Arg Asn Asp Thr Asn Asp Gln Ser Phe Ile Asp Tyr Leu Ser Ser Ala 595 600 605 Asn Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr 610 615 620 Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg 625 630 635 640 Ile Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr 645 650 655 Phe Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu 660 665 670 Ser His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln 675 680 685 Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys 690 695 700 Arg Val Val Asp Gly Glu Gly Tyr Gly Val Ala Gln Ser Asn Met Thr 705 710 715 720 Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr 725 730 735 Gln Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe 740 745 750 Leu Arg Asn Phe Gln Pro Met Cys Arg Gln Met Val Asp Ser Thr Arg 755 760 765 Tyr Gln Ala Cys Gln Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser 770 775 780 Gly Phe Thr Ala Phe Ala Asn Ala Ser Leu Pro Arg Glu Gly His Pro 785 790 795 800 Tyr Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro 805 810 815 Cys Thr Thr Gln Lys Lys Phe Leu Cys Asp Lys Thr Leu Trp Arg Ile 820 825 830 Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly 835 840 845 Gln Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe 850 855 860 Glu Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu 865 870 875 880 Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 885 890 895 Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr 900 905 910 <210> 45 <211> 909 <212> PRT <213> Ovine adenovirus 3 <400> 45 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala 115 120 125 Ser Val Asn Asn Thr Leu Ile Ile Ser Asn Asp Ala Asn Lys Pro Gln 130 135 140 Ala Ile Gly Gln Ala Ser Tyr Asp Cys Glu Ile Asn Asp Asp Thr Gly 145 150 155 160 Ala Ile Glu Ile Gly Gly Gln Asn Pro Thr Asp Leu Ala Tyr Gln Pro 165 170 175 Asn Pro Gln Ile Gly Gln Glu Thr Trp Val Phe Asp Asn Phe Gly Lys 180 185 190 Met Thr Gln Gly Ala Gly Arg Met Leu Asn Thr Asp Thr Lys Pro Leu 195 200 205 Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asn Gly Gly Gln 210 215 220 Gly Leu Ala Gln Pro Thr Thr Ile Asn Phe Ala Ser Gly Asp Gln Ala 225 230 235 240 Asp Thr Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Asn Leu Gln Ala 245 250 255 Pro Asp Thr His Leu Val Tyr Lys Val Ala Ala Asp Lys Val Gly Lys 260 265 270 Thr Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile 275 280 285 Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly 290 295 300 Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 305 310 315 320 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp 325 330 335 Ser Leu His Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile 340 345 350 Asp Ser Tyr Asp Thr Asp Val Arg Ile Met Glu Asn His Gly Val Glu 355 360 365 Asp Glu Met Pro Asn Tyr Cys Phe Pro Val Ser Gly Ile Gln Thr Leu 370 375 380 Ser Thr Ala Thr Lys Val Lys Lys Gly Ala Ala Asp Trp Glu Thr Asp 385 390 395 400 Thr Asp Ala Asn Gly Val Asn Tyr Ile Thr Leu Gly Asn Leu Asn Cys 405 410 415 Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr Ser 420 425 430 Asn Ile Ala Leu Tyr Leu Pro Asp Glu Phe Lys Phe Thr Pro Glu Asn 435 440 445 Val Asp Leu Pro Glu Asn Lys Asn Thr Tyr Ala Tyr Met Asn Gly Arg 450 455 460 Leu Pro Ala Gly Gly Leu Ile Asp Thr Tyr Val Asn Ile Gly Ala Arg 465 470 475 480 Trp Ser Pro Asp Val Met Asp Val Val Asn Pro Phe Asn His His Arg 485 490 495 Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr 500 505 510 Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Asn 515 520 525 Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys 530 535 540 Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val 545 550 555 560 Asp Gly Ala Ser Ile Asn Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe 565 570 575 Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 580 585 590 Asn Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn 595 600 605 Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr Ile 610 615 620 Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu 625 630 635 640 Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe 645 650 655 Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser 660 665 670 His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp 675 680 685 Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg 690 695 700 Ala Val Asp Gly Glu Gly Tyr Ser Val Ala Gln Ser Asn Met Thr Lys 705 710 715 720 Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln 725 730 735 Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu 740 745 750 Arg Asn Phe Gln Pro Met Cys Arg Gln Ile Val Asp Ser Thr Arg Tyr 755 760 765 Asp Ala Tyr Lys Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser Gly 770 775 780 Phe Thr Ala Phe Ala Asn Ser Ser Leu Pro Gly Glu Gly His Pro Tyr 785 790 795 800 Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro Cys 805 810 815 Thr Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro 820 825 830 Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln 835 840 845 Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu 850 855 860 Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val 865 870 875 880 Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr 885 890 895 Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr 900 905 <210> 46 <211> 910 <212> PRT <213> Bovine adenovirus 2 <400> 46 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Ser Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Thr Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Cys Leu Ala Pro Lys Ala 115 120 125 Ser Val Asn Asn Thr Leu Ile Ile Ser Asn Asp Ala Asn Lys Pro Gln 130 135 140 Ala Ile Gly Gln Ala Ser Tyr Asp Cys Ala Ile Asn Asp Asp Thr Gly 145 150 155 160 Ala Ile Glu Ile Gly Gly Pro Asn Pro Thr Asp Leu Ala Tyr Gln Pro 165 170 175 Asn Pro Gln Ile Gly Gln Glu Thr Trp Val Phe Asp Asn Phe Gly Lys 180 185 190 Met Thr Gln Gly Ala Gly Arg Met Leu Asn Thr Asp Thr Lys Pro Leu 195 200 205 Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asn Gly Gly Gln 210 215 220 Gly Leu Ala Gln Pro Thr Thr Ile Asn Phe Val Ser Gly Asp Gln Ala 225 230 235 240 Asp Thr Pro Asp Thr Gly Phe Ala Leu Glu Asn Val Asn Leu Gln Ala 245 250 255 Pro Asp Thr His Leu Val Tyr Lys Val Ala Ala Asp Lys Val Gly Lys 260 265 270 Thr Ala Ala Leu Gly Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Ile 275 280 285 Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn Gly 290 295 300 Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 305 310 315 320 Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met Leu Asp 325 330 335 Ser Leu His Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln Ala Ile 340 345 350 Asp Ser Tyr Asp Thr Asp Val Arg Ile Met Glu Asn His Gly Val Glu 355 360 365 Asp Glu Met Pro Asn Tyr Cys Phe Pro Val Ser Gly Ile Gln Thr Leu 370 375 380 Ser Lys Ala Thr Lys Val Lys Lys Gly Val Ala Asn Trp Glu Thr Asp 385 390 395 400 Thr Asp Ala Asn Gly Val Asn Tyr Ile Thr Leu Gly Asn Leu Asn Cys 405 410 415 Met Glu Ile Asn Leu Ser Ala Asn Leu Trp Lys Gly Phe Leu Tyr Ser 420 425 430 Asn Ile Ala Leu Tyr Leu Pro Asp Glu Phe Lys Phe Thr Pro Glu Asn 435 440 445 Val Asp Leu Pro Glu Asn Lys Asn Thr Tyr Ala Tyr Met Asn Gly Arg 450 455 460 Leu Pro Ala Gly Gly Leu Ile Asp Thr Tyr Val Asn Ile Gly Ala Arg 465 470 475 480 Trp Ser Pro Asp Val Asn Gly Arg Cys Lys Pro Ile Tyr His His Arg 485 490 495 Asn Ala Gly Leu Arg Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr 500 505 510 Cys Gln Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Leu Lys Asn 515 520 525 Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys 530 535 540 Asp Val Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val 545 550 555 560 Asp Gly Ala Ser Ile Lys Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe 565 570 575 Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 580 585 590 Asn Asp Thr Asn Asp Gln Ser Phe Ile Glu Tyr Leu Ser Ser Ala Asn 595 600 605 Met Leu Tyr Pro Ile Pro Ala Lys Ala Thr Asn Ile Pro Ile Thr Ile 610 615 620 Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu 625 630 635 640 Lys Gln Lys Glu Thr Pro Ala Leu Gly Ser Pro Phe Asp Pro Tyr Phe 645 650 655 Thr Tyr Ser Gly Thr Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser 660 665 670 His Thr Phe Lys Arg Val Ser Ile Gln Phe Asp Ser Ser Val Gln Trp 675 680 685 Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg 690 695 700 Ala Val Asp Gly Glu Gly Tyr Ser Val Ala Gln Ser Asn Met Thr Lys 705 710 715 720 Asp Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln 725 730 735 Gly Tyr His Leu Pro Asp Gly Tyr Lys Asp Arg Thr Tyr Ser Phe Leu 740 745 750 Arg Asn Phe Gln Pro Met Cys Arg Gln Ile Val Asp Ala Thr Arg Tyr 755 760 765 Asn Asp Tyr Lys Glu Val Thr Ile Ser Asn Gln His Asn Asn Ser Gly 770 775 780 Phe Thr Ala Phe Ala Asn Ala Ser Leu Pro Arg Glu Gly His Pro Tyr 785 790 795 800 Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asn Val Ala Pro Cys 805 810 815 Ala Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro 820 825 830 Phe Ser Ser Asn Phe Met Ser Met Gly Ser Phe Thr Asp Leu Gly Gln 835 840 845 Asn Leu Leu Tyr Ala Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu 850 855 860 Val Asp Ala Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val 865 870 875 880 Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Thr 885 890 895 Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 910 <210> 47 <211> 920 <212> PRT <213> Alpaca adenovirus CA/2007 <400> 47 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Gln Ala Thr Glu Thr Tyr Phe Lys Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Glu Arg Ser Gln Arg Leu 50 55 60 Gln Leu Arg Phe Val Pro Val Asp Lys Glu Asp Thr Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ala Val Gly Asp Asn Arg Leu Leu Asp Met 85 90 95 Gly Ser Ser Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser 115 120 125 Ser Val Asn Asn Cys Gly Phe Thr Ser Ala Ala Asp Leu Pro Gln Tyr 130 135 140 Ile Ala Gln Ala Ser Phe Ile Asn Asp Ile Asn Thr Asn Thr Gly Glu 145 150 155 160 Met Gln Val Gly Glu Asn Asp Gln Gly Gln Pro Val Tyr Ala Asp Lys 165 170 175 Thr Tyr Gln Pro Glu Pro Gln Ile Gly Asn Gln Ser Trp Ser Gln Gly 180 185 190 Pro Gln Asn Thr Leu Leu Ala Asp Ile Glu Gly Ala Gly Arg Ala Leu 195 200 205 Lys Pro Thr Thr Pro Arg Asn Pro Cys Tyr Gly Ser Tyr Ala Ala Pro 210 215 220 Thr Asn Glu Asn Gly Ala Gln Ala Thr Gly Glu Val Asp Leu Val Phe 225 230 235 240 Leu Thr Gln Gly Asn Thr Ala Gly Pro Pro Thr Ser Val Leu Tyr Thr 245 250 255 Glu Asp Val Ala Leu Thr Ala Pro Asp Thr His Phe Val Tyr Lys Val 260 265 270 Ala Asp Asp Asp Leu Ala Thr Ala Pro Gly Leu Gly Gln Gln Ala Ala 275 280 285 Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu 290 295 300 Met Tyr Tyr Asn Ser Asn Gly Asn Leu Gly Val Leu Ala Gly Gln Ala 305 310 315 320 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 325 330 335 Ser Tyr Gln Leu Met Leu Asp Asn Leu Tyr Asp Arg Ser Arg Tyr Phe 340 345 350 Ser Ile Trp Asn Gln Ala Ile Asp Ser Tyr Asp Gln Asp Val Arg Val 355 360 365 Leu Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 370 375 380 Leu Ser Gly Val Leu Tyr Thr Thr Pro Thr Ser Met Gln Val Val Arg 385 390 395 400 Gly Ala Asp Gln Asn Asp Gly Trp Ile Ala Asn Asn Ala Gly Ser Gly 405 410 415 Ile Asn Tyr Ile Asn Asn Gly Asn Leu Asp Cys Met Glu Ile Asn Leu 420 425 430 Ala Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Ile Ala Leu Tyr 435 440 445 Leu Pro Asp Asn Leu Lys Phe Thr Pro Asn Asn Val Ile Leu Ser Asn 450 455 460 Asn Pro Asn Thr Tyr Asn Tyr Met Asn Gly Arg Ile Pro Ala Ala Gly 465 470 475 480 Leu Val Asp Ser Phe Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Val 485 490 495 Met Asp Ser Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 500 505 510 Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Ser Phe His Ile 515 520 525 Gln Val Pro Gln Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro 530 535 540 Gly Thr Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile 545 550 555 560 Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile 565 570 575 Ile Ile Asp Ser Val Asn Leu Tyr Ala Ser Phe Phe Pro Met Ala His 580 585 590 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp 595 600 605 Gln Ser Phe Ile Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile 610 615 620 Pro Ala Gly Ala Thr Asn Ile Pro Ile Ser Ile Pro Ser Arg Asn Trp 625 630 635 640 Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Gln Lys Glu Thr 645 650 655 Pro Ala Leu Gly Ser Ala Tyr Asp Pro Tyr Phe Thr Tyr Ser Gly Thr 660 665 670 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Arg Arg 675 680 685 Leu Ala Ile Gln Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 690 695 700 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Val Val Asp Gly Glu 705 710 715 720 Gly Tyr Asn Val Ala Gln Ser Asn Met Ser Lys Asp Trp Phe Leu Ile 725 730 735 Gln Met Leu Thr Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Leu Pro 740 745 750 Glu Gly Phe Arg Asp Arg Thr Tyr Ser Phe Leu Arg Asn Phe Gln Pro 755 760 765 Met Cys Arg Gln Val Val Asp Thr Asp Asn Phe Ala Asp Tyr Lys Pro 770 775 780 Val Gln Leu Gln His Gln His Asn Asn Ser Gly Phe Thr Gly Phe Ala 785 790 795 800 Ala Ala Ser Ala Ala Arg Glu Gly His Pro Tyr Pro Ala Asn Trp Pro 805 810 815 Tyr Pro Leu Ile Gly Glu Asn Ala Val Arg Thr Thr Thr Gln Lys Lys 820 825 830 Phe Leu Cys Asp Arg Thr Leu Trp Ser Ile Pro Phe Ser Ser Asn Phe 835 840 845 Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala 850 855 860 Asn Ala Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Ala Leu Asp 865 870 875 880 Glu Ala Thr Leu Leu Tyr Val Leu Phe Gln Val Phe Asp Val Cys Arg 885 890 895 Val His Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr 900 905 910 Pro Phe Ser Ala Gly Asn Ala Thr 915 920 <210> 48 <211> 909 <212> PRT <213> Murine adenovirus 1 <400> 48 Met Thr Thr Pro Ser Met Gln Pro Gln Trp Ala Phe Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Gln Tyr Leu Ser Pro Gly Val Val Gln Phe Ala 20 25 30 Ala Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Ile Val Pro Val Asp Arg Glu Asp Ser Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ser Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ala 115 120 125 Ala Pro Asn Asn Leu Met Phe Lys Thr Gly Ala Asp Ser Lys Thr Met 130 135 140 Thr Ile Ala Gln Ala Asn Ile Val Gly Ser Thr Ile Asp Gln Asp Gly 145 150 155 160 Leu Lys Ile Asn Asn Val Ala Leu Asn Pro Asn Ala Gly Glu Pro Ala 165 170 175 Val Gln Glu Gly Leu Glu Asn Trp Met Glu Glu Leu Gln Ile Gly Ala 180 185 190 Asp Lys Lys Phe Ala Ser Arg Val Leu Lys Ala Asp Gln Pro Val Leu 195 200 205 Pro Asn Tyr Gly Ser Tyr Ala Tyr Pro Thr Asn Ile Asn Gly Thr Gln 210 215 220 Thr Lys Asp Gly Thr Thr Val Asp Lys Val Tyr Met Cys Ser Lys Gly 225 230 235 240 Ala Asn Val Gln Asn Pro Asp Val Val Leu Tyr Ser Glu Glu Val Asn 245 250 255 Leu Gln Ala Pro Asp Thr His Leu Leu Asp Gly Pro Gly Ala Asp Asn 260 265 270 Pro Lys Asp Arg Val Ala Phe Cys Ala Ala Pro Asn Arg Pro Asn Tyr 275 280 285 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn 290 295 300 Gly Asn Gln Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 305 310 315 320 Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Phe Leu Leu 325 330 335 Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala 340 345 350 Ile Asp Ser Tyr Asp Pro Arg Val Arg Ile Ile Glu Asn Asp Gly Val 355 360 365 Glu Asp Asp Ile Thr Ser Phe Ala Phe Asp Leu Arg Gly Ile Gly Asp 370 375 380 Leu Pro Tyr Lys Gln Val Gln Thr His Asn Gly Asn Gln Gln Ser Ala 385 390 395 400 Asn Thr Thr Asp Thr Cys Tyr Ile Gly Lys Gly Asn Met Ala Ala Met 405 410 415 Glu Ile Asn Ile Pro Ala Asn Leu Trp Leu Gly Phe Leu Tyr Ala Asn 420 425 430 Val Ala Gln Tyr Met Pro Asp Asp Phe Lys Val Asp Pro Ser Asn Ile 435 440 445 Gln Met Pro Gln Asp Lys Thr Thr Tyr Ala Tyr Met Asn Gln Arg Ile 450 455 460 Ala Pro Ala Gly Leu Ile Glu Thr Tyr Val Asn Val Gly Gly Arg Trp 465 470 475 480 Ser Val Asp Phe Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn 485 490 495 Glu Gly Leu Lys Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Phe Val 500 505 510 Asp Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu 515 520 525 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp 530 535 540 Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp 545 550 555 560 Gly Ala Arg Leu Glu Ile His Ser Val Asn Leu Tyr Ala Ser Phe Phe 565 570 575 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 580 585 590 Glu Thr Asn Asp Gln Thr Phe Leu Asp Tyr Leu Ser Ser Ala Thr Met 595 600 605 Met Phe Pro Ile Pro Ala Gly Gln Thr Gln Val Pro Val Ser Ile Pro 610 615 620 Ala Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys 625 630 635 640 Gln Gln Glu Thr Pro Asn Ile Gly Ser Pro Tyr Asp Pro Tyr Phe Lys 645 650 655 Tyr Ser Gly Ser Ile Pro Phe Leu Asp Ala Thr Phe Tyr Leu Thr His 660 665 670 Thr Phe Gln Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro 675 680 685 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg His 690 695 700 Ile Asp Ala Glu Gly Leu Cys Val Gly Gln Ser Asn Met Thr Lys Asp 705 710 715 720 Trp Phe Leu Val Gln Met Leu Ser Asn Tyr Asn Ile Gly Tyr Gln Gly 725 730 735 Phe Tyr Leu Pro Glu Asn Asn Lys Asp Arg Thr Tyr Ser Phe Val Arg 740 745 750 Asn Phe Glu Pro Leu Ala Arg Gln Val Val Asp Asp Ala Ala Ala Ala 755 760 765 Asn Tyr Arg Asp Val Pro Leu Ser Lys Arg Phe Asn Asn Ser Gly Trp 770 775 780 Arg Ser Ala Gly Pro Pro Ile Phe Ala Arg Glu Gly Ala Pro Tyr Pro 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Cys Gly Glu Ala Ala Trp Ala Ala Lys 805 810 815 Thr Gln Arg Lys Phe Leu Val Asp Arg Tyr Met Tyr Arg Ile Pro Phe 820 825 830 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn 835 840 845 Leu Leu Tyr Ala Asn Ser Ala His Ser Leu Glu Met Thr Phe Asn Val 850 855 860 Asp Pro Met Gln Glu Ala Thr Phe Leu Tyr Ile Leu Phe Glu Val Phe 865 870 875 880 Asp Cys Val Arg Ile His Gln Pro His Arg Gly Ile Ile Glu Ala Val 885 890 895 Tyr Leu Arg Ser Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 <210> 49 <211> 909 <212> PRT <213> Murine adenovirus 3 <400> 49 Met Thr Thr Pro Ser Met Gln Pro Gln Trp Ala Phe Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Gln Tyr Leu Ser Pro Gly Val Met Gln Phe Ala 20 25 30 Ala Ala Thr Glu Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Ile Val Pro Val Asp Arg Glu Asp Ser Gln Tyr Thr Tyr 65 70 75 80 Lys Thr Arg Phe Gln Leu Ser Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Arg Ala 115 120 125 Ala Pro Asn Asn Leu Met Tyr Gln Val Gly Gly Asn Asn Pro Lys Thr 130 135 140 Lys Thr Ile Ala Gln Ala Asn Ile Pro Gly Thr Gln Ile Asp Ala Asn 145 150 155 160 Gly Leu Gln Val Asn Asn Gln Asn Leu Asp Ile Gln Arg Gly Glu Pro 165 170 175 Glu Val Gln Val Gly Tyr Gln Asn Trp Met Asp Glu Leu Glu Pro Gly 180 185 190 Asn Gln Pro Lys Tyr Ala Gly Arg Val Leu Lys Thr Asn Gln Pro Val 195 200 205 Leu Pro Asn Tyr Gly Ser Tyr Ala Phe Pro Thr Asn Glu Asn Gly Thr 210 215 220 Gln Thr Lys Asn Gly Thr Gln Val Asp Lys Val Phe Met Leu Pro Lys 225 230 235 240 Val Asn Ala Gln Asn Ala Asp Val Val Leu Tyr Ser Glu Glu Val Asn 245 250 255 Leu Gln Ala Pro Asp Thr His Leu Leu Glu Gly Pro Ser Ala Ala Thr 260 265 270 Ala Thr Asn Arg Val Ala Ile Gln Ala Ala Pro Asn Arg Pro Asn Tyr 275 280 285 Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Asn 290 295 300 Gly Asn Gln Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val 305 310 315 320 Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Phe Leu Leu 325 330 335 Asp Ser Leu Tyr Asp Arg Ser Arg Tyr Phe Ser Leu Trp Asn Gln Ala 340 345 350 Ile Asp Ser Tyr Asp Pro Arg Val Arg Ile Ile Glu Asn Asp Gly Val 355 360 365 Glu Asp Asp Ile Thr Ser Phe Ala Phe Asp Leu Arg Gly Val Gly Arg 370 375 380 Leu Glu Tyr Lys Gln Val Gln Thr His Gln Gly Asn Gln Gln Ala Asn 385 390 395 400 Asn Ala Asp Asp Thr Ser Tyr Ile Gly Lys Gly Asn Met Ala Ala Met 405 410 415 Glu Ile Asn Ile Pro Ala Asn Met Trp Ile Gly Phe Leu Tyr Ala Asn 420 425 430 Val Ala Gln Tyr Val Pro Asp Ala Tyr Lys Val Asp Pro Thr Asn Ile 435 440 445 Ala Met Pro Glu Asn Lys Asn Thr Tyr Ser Tyr Met Asn Gln Arg Ile 450 455 460 Ala Pro Thr Gly Leu Val Glu Thr Tyr Val Asn Met Gly Gly Arg Trp 465 470 475 480 Ser Val Asp Phe Met Asp Thr Val Asn Pro Phe Asn His His Arg Asn 485 490 495 Asp Gly Leu Lys Tyr Arg Ser Gln Val Leu Gly Asn Gly Arg Tyr Val 500 505 510 Asp Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu 515 520 525 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp 530 535 540 Val Asn Met Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp 545 550 555 560 Gly Ala Ser Leu Glu Ile His Ser Val Asn Leu Tyr Ala Ser Phe Phe 565 570 575 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 580 585 590 Glu Thr Asn Asp Gln Thr Phe Leu Glu Tyr Leu Ser Ser Ala Thr Met 595 600 605 Met Phe Pro Ile Pro Ala Gly Gln Thr Gln Ile Pro Val Ser Ile Pro 610 615 620 Ala Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys 625 630 635 640 Gln Ser Glu Thr Pro Asn Ile Gly Ser Pro Phe Asp Pro Tyr Phe Thr 645 650 655 Tyr Ser Gly Ser Ile Pro Phe Leu Asp Ala Thr Phe Tyr Leu Thr His 660 665 670 Thr Phe Gln Arg Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro 675 680 685 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Asn 690 695 700 Ile Asp Gly Glu Gly Leu Cys Val Ala Gln Ser Asn Met Thr Lys Asp 705 710 715 720 Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly 725 730 735 Tyr His Leu Pro Asp Asn Asn Lys Asp Arg Thr Tyr Ser Phe Leu Arg 740 745 750 Asn Phe Glu Pro Met Thr Arg Gln Val Val Asp Arg Gln Leu Asp Gly 755 760 765 Arg Tyr Val Asp Val Met Leu Thr Lys Arg Phe Asn Asn Ser Gly Trp 770 775 780 Lys Ser Ala Ser Ala Pro Ile Phe Pro Arg Glu Gly Ala Pro Tyr Pro 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Cys Gly Glu Met Ala Trp Ala Thr Arg 805 810 815 Thr Gln Arg Lys Phe Leu Val Asp Arg Tyr Met Tyr Arg Ile Pro Phe 820 825 830 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn 835 840 845 Leu Leu Tyr Ala Asn Ser Ala His Ser Leu Glu Met Thr Phe Glu Val 850 855 860 Asp Pro Met Thr Glu Ala Thr Tyr Leu Tyr Ile Leu Phe Glu Val Phe 865 870 875 880 Asp Cys Val Arg Ile His Gln Pro His Arg Gly Ile Ile Glu Ala Val 885 890 895 Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 900 905 <210> 50 <211> 910 <212> PRT <213> Bovine adenovirus 4 <400> 50 Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg 1 5 10 15 Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Ser 20 25 30 Phe Phe Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Thr 35 40 45 Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val 50 55 60 Pro Ile Gln Val Glu Asp Asn Glu Asn Phe Phe Lys Ala Arg Phe Thr 65 70 75 80 Leu Asn Val Gly Asp Asn Arg Ile Ala Asp Leu Gly Ser Ala Phe Phe 85 90 95 Asp Ile Glu Gly Phe Ile Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly 100 105 110 Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Leu Pro Asn Met 115 120 125 Ala Phe Lys Asn Asn Glu Glu Thr Thr Tyr Ile Ala Gln Leu Pro Gln 130 135 140 Ile Tyr Ala Ala Glu Asp Lys Gly Leu Glu Thr Ser Gln Leu Val Phe 145 150 155 160 Leu Phe Pro Ala Thr Lys Pro Asn Pro Gln Glu Gly Arg Ser Asp Glu 165 170 175 Gly Ile Ile Met Ala Leu Met Ile Leu Asp Thr Lys Lys Phe Gly Ala 180 185 190 Tyr Gly Arg Leu Ile Gly Ala Asp Ser Gln Gly Lys Ile Phe Pro Ala 195 200 205 Tyr Gly Ser Tyr Val Lys Pro Val Ser Val Glu Gly Ser Val Ser Thr 210 215 220 Ala Asp Val Gln Arg Val Tyr Leu Asn Thr Thr Asp Val Asn Asp Arg 225 230 235 240 Val Ser Gly Val Leu Ala Val Asp Thr Val Gln Arg Leu Asn Pro Asp 245 250 255 Cys His Tyr Ala Glu Tyr Thr Asn Glu Val Lys Ile Thr Ser Ser Gly 260 265 270 Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Val Gly Leu Met 275 280 285 Tyr Tyr Asn Asn Gly Ser Asn Ala Gly Thr Phe Pro Ser Gln Thr Gln 290 295 300 Gln Leu Asn Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser 305 310 315 320 Tyr Gln Tyr Leu Ile Ala Glu Ile Ser Ser Arg Tyr Lys His Phe Ala 325 330 335 Leu Trp Asn Gln Ala Val Asp Thr Tyr Asp Glu Asn Val Arg Ile Ile 340 345 350 His Asn Glu Gly Tyr Glu Glu Gly Pro Pro Val Leu Ser Phe Pro Pro 355 360 365 Phe Gly Ile Gln Asn Phe Phe Ser Asp Thr Asp Glu Gly Thr Ala Met 370 375 380 Thr Ile Gln Glu Gly Asn Gln Gln Ala Gln Lys Leu Thr Ile Gln Ser 385 390 395 400 Leu Trp Leu Trp Asn Ile Pro Thr Leu Glu Met Asn Leu Ala Ala Asn 405 410 415 Leu Gln Arg Thr Phe Leu Trp Ala Asn Val Ala Met Tyr Leu Pro Asp 420 425 430 Asn Leu Lys Arg Thr Pro Pro Asn Val Asp Leu Pro Ala Asn Lys Asn 435 440 445 Thr Tyr Gly Tyr Met Asn Gly Arg Ile Pro Tyr Pro Asn Val Ile Asp 450 455 460 Thr Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Ile Met Asp Thr 465 470 475 480 Ile Asn Pro Phe Asn His His Arg Asn Thr Gly Leu Lys Tyr Arg Ser 485 490 495 Gln Leu Leu Gly Asn Gly Arg Phe Ser Arg Phe His Ile Gln Val Pro 500 505 510 Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr 515 520 525 Asn Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Ile Phe Gln Ser 530 535 540 Ser Ile Gly Asn Asp Leu Arg Ala Asp Gly Ala Tyr Ile Asn Tyr Ser 545 550 555 560 Asn Ile Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Asp Thr Val 565 570 575 Ser Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe 580 585 590 Ala Asp Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Pro Asn 595 600 605 Thr Ser Thr Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala Phe 610 615 620 Arg Gly Trp Ser Phe Asn Arg Val Lys Ala Ser Glu Thr Pro Met Ile 625 630 635 640 Gly Ala Thr Lys Asp Pro Asn Phe Leu Tyr Ser Gly Ser Ile Pro Tyr 645 650 655 Leu Asp Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile 660 665 670 Gln Trp Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Ile 675 680 685 Pro Asn Trp Phe Glu Ile Lys Arg Asp Tyr Ser Ile Asp Ala Glu Ala 690 695 700 Thr Asn Met Ser Gln Cys Asn Ile Thr Lys Asp Trp Tyr Met Ile Gln 705 710 715 720 Met Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Leu Pro Ile 725 730 735 Ser His Lys Tyr Tyr Gly Phe Leu Glu Asn Phe Gln Pro Met Ser Arg 740 745 750 Gln Val Pro Ile Tyr Gly Gly Asp Leu Tyr Asp Leu Tyr Thr Glu Tyr 755 760 765 Ile Lys Asn Pro Asn Leu Met Gln Ile Trp Asn Asn Cys Gly Leu Gln 770 775 780 Gln Lys Thr Ser Gly Ile Pro Leu Leu Glu Asn Ser Gly His Leu Tyr 785 790 795 800 Val Ala Asn Trp Pro Tyr Pro Leu Ile Gly Lys His Ala Ile Glu Ser 805 810 815 Gln Lys Leu Gln Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro 820 825 830 Phe Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln 835 840 845 Asn Val Leu Tyr Ala Asn Ala Ser His Ser Leu Asn Met Val Phe Thr 850 855 860 Val Asp Pro Met Gln Glu Thr Thr Tyr Leu Met Leu Leu Phe Gly Val 865 870 875 880 Phe Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val 885 890 895 Ala Tyr Leu Arg Leu Pro Phe Ser Ala Gly Ser Ala Thr Thr 900 905 910 <210> 51 <211> 903 <212> PRT <213> Odocoileus adenovirus 1 <400> 51 Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg 1 5 10 15 Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Ser 20 25 30 Phe Phe Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Ser 35 40 45 Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val 50 55 60 Pro Ile Gln Thr Glu Asp Asn Glu Asn Phe Tyr Lys Ala Arg Phe Thr 65 70 75 80 Leu Asn Val Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe 85 90 95 Asp Ile Glu Gly Thr Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly 100 105 110 Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Met Pro Asn Ile 115 120 125 Thr Val Thr Lys Gly Gly Asp Thr Ile Tyr Ile Ala Gln Leu Pro Gln 130 135 140 Thr Tyr Ala Ala Asn Asp Lys Gly Val Pro Glu Ala Ile Ala Val Gln 145 150 155 160 Thr Thr Ala Ile Lys Pro Asn Pro Gln Ser Gly Gln Thr Glu Asp Phe 165 170 175 Ala Gly Val Asp Lys Val Asp Pro Thr Thr Thr Gly Gly Gln Gly Arg 180 185 190 Ile Leu Ser Ala Thr Ser Val Gly Asp Val Phe Pro Ala Tyr Gly Ser 195 200 205 Tyr Ala Pro Pro Gln Ser Val Thr Gly Asp Ile Ser Thr Glu Ala Val 210 215 220 Thr Arg Val Tyr Leu Asn Thr Thr Thr Thr Glu Asp Arg Val Ser Gly 225 230 235 240 Ile Thr Ala Val Asp Lys Ala Ile Arg Lys His Pro Asp Ala His Phe 245 250 255 Val Glu Phe Val Glu Asp Gly Lys Ala Thr Ser Ser Gly Asn Arg Pro 260 265 270 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile Met Phe Tyr Asn 275 280 285 Asn Gly Ser Asn Ala Gly Thr Leu Ser Ser Gln Thr Gln Gln Leu Asn 290 295 300 Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr 305 310 315 320 Leu Leu Ala Asp Ile Ser Asn Arg Tyr Lys Tyr Phe Ala Leu Trp Asn 325 330 335 Gln Ala Val Asp Asn Tyr Asp Glu Tyr Val Arg Ile Leu His Asn Glu 340 345 350 Gly Tyr Glu Glu Gly Pro Pro Val Leu Ser Phe Pro Pro Asn Gly Val 355 360 365 Gln Asn Tyr Phe Thr Pro Pro Ala Lys Gly Asn Ala Met Thr Val Asp 370 375 380 Thr Gly Arg Asn Thr Ala Ala Lys Thr Asp Asn Thr Lys Ala Phe Ile 385 390 395 400 Gly Tyr Gly Asn Ile Pro Ser Leu Glu Met Asn Leu Ser Ala Asn Leu 405 410 415 Gln Arg Thr Phe Leu Trp Ala Asn Val Ala Met Tyr Leu Pro Asp Lys 420 425 430 Tyr Lys Lys Thr Pro Asn Asn Val Asp Leu Pro Ala Asn Thr Asn Ser 435 440 445 Tyr Gly Tyr Ile Asn Gly Arg Ile Pro Ile Pro Asn Val Ile Asp Thr 450 455 460 Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Asn Val 465 470 475 480 Asn Pro Phe Asn His His Arg Asn Asn Gly Leu Lys Tyr Arg Ser Gln 485 490 495 Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val Pro Gln 500 505 510 Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn 515 520 525 Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Ile Val Leu Gln Ser Ser 530 535 540 Ile Gly Asn Asp Leu Arg Ala Asp Gly Ala Ile Ile Thr Tyr Thr Ser 545 550 555 560 Ile Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Glu Thr Val Ser 565 570 575 Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ala 580 585 590 Asp Phe Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala Asn Thr 595 600 605 Asn Thr Ile Val Val Asn Ile Pro Asp Arg Ser Trp Gly Ala Phe Arg 610 615 620 Gly Trp Ser Phe Asn Arg Ile Lys Ala Thr Glu Thr Pro Met Ile Gly 625 630 635 640 Ala Thr Lys Asp Pro Asn Phe Asn Tyr Ser Gly Ser Ile Pro Tyr Leu 645 650 655 Asp Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile Gln 660 665 670 Trp Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Ile Pro 675 680 685 Asn Trp Phe Glu Ile Lys Arg Glu Pro Asn Tyr Asp Pro Glu Gly Tyr 690 695 700 Asn Ile Ser Gln Ser Thr Leu Thr Lys Asp Phe Phe Met Val Gln Met 705 710 715 720 Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Leu Pro Ser Thr 725 730 735 Tyr Lys His Tyr Gly Phe Ile Glu Asn Phe Glu Pro Met Ser Arg Gln 740 745 750 Val Pro Val Tyr Gly Asp Asp Val Phe Asp Leu Tyr Asn Ala Tyr Leu 755 760 765 Gln Asp Pro Thr Asn Met Gln Ile Trp Asn Asn Cys Gly Leu Gln Gln 770 775 780 Lys Thr Thr Asn Ile Ser Leu Leu Glu Asn Ser Gly His Leu Tyr Val 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Val Gly Arg Asp Ala Val Glu Asn Gln 805 810 815 Thr Thr Glu Lys Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro 820 825 830 Phe Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln 835 840 845 Asn Val Leu Tyr Ala Asn Ser Ser His Ser Leu Asn Met Val Phe Thr 850 855 860 Val Asp Ser Met Pro Glu Asn Thr Tyr Leu Met Leu Leu Phe Gly Val 865 870 875 880 Phe Asp Gln Val Val Val Asn Gln Pro Thr Arg Ser Gly Ile Ser Val 885 890 895 Ala Tyr Leu Arg Leu Pro Phe 900 <210> 52 <211> 902 <212> PRT <213> Goat adenovirus 1 <400> 52 Pro Gln Arg Asp Phe Phe His Ile Ala Gly Arg Asn Ala Arg Glu Tyr 1 5 10 15 Leu Ser Glu Asn Leu Val Gln Phe Ile Ser Ala Thr Gln Ser Phe Phe 20 25 30 Asn Leu Gly Glu Lys Phe Arg Asp Pro Phe Val Ala Pro Ser Thr Gly 35 40 45 Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val Pro Ile 50 55 60 Gln Thr Glu Asp Asn Glu Asn Phe Tyr Lys Thr Arg Phe Thr Leu Asn 65 70 75 80 Val Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe Asp Ile 85 90 95 Glu Gly Val Ile Asp Arg Gly Pro Thr Phe Lys Pro Tyr Gly Gly Thr 100 105 110 Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Phe Pro Asn Ala Ala Phe 115 120 125 Met Asp Asn Asp Glu Ala Thr Thr Val Tyr Ile Ala Gln Leu Pro Asn 130 135 140 Ala Tyr Lys Ala Gln Asn Lys Gly Val Glu Glu Ala Ile Arg Val Glu 145 150 155 160 Ala Asn Thr Thr Thr Pro Asn Pro Gln Ser Gly Asp Tyr Ala Thr Tyr 165 170 175 Asp Thr Ala Lys Phe Asn Pro Glu Thr Thr Gly Ala Ser Gly Arg Leu 180 185 190 Leu Ser Ile Asn Ser Leu Gly Asp Leu Phe Pro Ala Tyr Gly Ser Tyr 195 200 205 Cys Arg Pro Gln Ser Ala Asp Gly Asn Ile Ser Thr Ala Pro Ile Thr 210 215 220 Lys Val Tyr Leu Asn Thr Thr Ala Thr Asp Asp Arg Val Ser Gly Val 225 230 235 240 Thr Ala Val Asp Thr Ala Thr Arg Leu His Pro Asp Ala His Tyr Ile 245 250 255 Glu Tyr Thr Asp Glu Ala Lys Ala Thr Ala Ile Gly Asn Arg Pro Asn 260 265 270 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Phe Tyr Asn Asn 275 280 285 Gly Ser Asn Ala Gly Thr Phe Ser Ser Gln Thr Gln Gln Leu Asn Val 290 295 300 Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Leu 305 310 315 320 Ile Ala Asp Leu Thr Asp Arg Tyr Arg Tyr Phe Ala Leu Trp Asn Gln 325 330 335 Ala Val Asp Ser Tyr Asp Ser His Val Arg Ile Leu His Asn Glu Gly 340 345 350 Tyr Glu Glu Gly Pro Pro Ala Leu Ser Phe Pro Ser Gln Gly Ile Gln 355 360 365 Asn Tyr Phe Met Pro Thr Ala Ala Gly Asn Ala Met Thr Val Asp Thr 370 375 380 Gly Arg Asn Thr Ala Ala Lys Thr Asp Asn Thr Lys Ala Phe Ile Gly 385 390 395 400 Tyr Gly Asn Ile Pro Ser Leu Glu Met Asn Leu Thr Ala Asn Leu Gln 405 410 415 Arg Thr Phe Leu Trp Ser Asn Val Ala Met Tyr Leu Pro Asp Arg Leu 420 425 430 Lys Thr Thr Pro Pro Asn Ile Asn Leu Pro Glu Asp Thr Asn Ser Tyr 435 440 445 Gly Tyr Met Asn Gly Arg Val Pro Leu Ala Asn Ile Ile Asp Thr Trp 450 455 460 Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn 465 470 475 480 Pro Phe Asn His His Arg Asn Ser Gly Leu Lys Tyr Arg Ser Gln Leu 485 490 495 Leu Gly Asn Gly Arg Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys 500 505 510 Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr 515 520 525 Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Val Phe Gln Ser Thr Leu 530 535 540 Gly Asn Asp Leu Arg Ala Asp Gly Ala Thr Ile Thr Tyr Thr Asn Ile 545 550 555 560 Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Glu Thr Val Ser Glu 565 570 575 Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ala Asp 580 585 590 Tyr Leu Gly Ala Val Thr Asn Leu Tyr Gln Ile Pro Ala Asn Thr Asn 595 600 605 Thr Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly 610 615 620 Trp Ser Phe Asn Arg Val Lys Ala Ser Glu Thr Pro Met Ile Gly Ala 625 630 635 640 Thr Lys Asp Pro Asn Phe Thr Tyr Ser Gly Ser Ile Pro Leu Leu Asp 645 650 655 Gly Thr Phe Tyr Leu Thr His Thr Phe Gln Arg Val Ser Ile Gln Trp 660 665 670 Asp Ser Ser Val Pro Trp Pro Gly Asp Asp Arg Leu Leu Val Pro Asn 675 680 685 Trp Phe Glu Ile Lys Arg Asp Pro Asn Met Asp Ala Glu Gly Tyr Thr 690 695 700 Met Ser Gln Ser Thr Ile Thr Lys Asp Phe Tyr Leu Val Gln Met Ala 705 710 715 720 Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Lys Met Pro Ile His Ser 725 730 735 Lys Tyr Tyr Gly Phe Leu Glu Asn Phe Gln Pro Met Ser Arg Gln Val 740 745 750 Pro Ile Tyr Gly Asn Gly Thr Tyr Asp Leu Tyr Thr Ala Tyr Val Thr 755 760 765 Asn Gln Arg Thr Met Gln Ile Trp Asn Asn Ser Gly Leu Glu Ser Lys 770 775 780 Thr Ser Asn Pro Pro Ile Leu Ser Asn Thr Gly His Leu Tyr Val Ala 785 790 795 800 Asn Trp Pro Tyr Pro Leu Ile Gly Pro Asn Ala Ile Glu Asn Gln Gln 805 810 815 Thr Glu Arg Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro Phe 820 825 830 Ser Ser Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln Ser 835 840 845 Val Leu Tyr Thr Asn Ser Ser His Ser Leu Asn Met Val Phe Thr Val 850 855 860 Asp Ser Met Pro Glu Thr Thr Tyr Leu Met Leu Leu Phe Gly Val Phe 865 870 875 880 Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala 885 890 895 Tyr Leu Arg Leu Pro Phe 900 <210> 53 <211> 907 <212> PRT <213> Possum adenovirus <400> 53 Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Arg 1 5 10 15 Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Ser Ala Thr Gln Thr 20 25 30 Phe Phe Asn Leu Gly Asp Lys Phe Arg Asp Pro Phe Val Ala Pro Ser 35 40 45 Ser Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Ile Val 50 55 60 Pro Ile Gln Thr Glu Asp Asn Glu Ser Phe Tyr Lys Ala Arg Phe Thr 65 70 75 80 Leu Asn Ile Gly Asp Asn Arg Val Ala Asp Leu Gly Ser Ala Tyr Phe 85 90 95 Asp Ile Glu Gly Ile Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly 100 105 110 Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Leu Pro Asn Thr 115 120 125 Ala Val Thr Glu Gly Thr Thr Leu Lys Tyr Tyr Ala Gln Leu Pro Gln 130 135 140 Leu Tyr Ser Ile Thr Asp Asn Gly Val Asn Ala Ser Thr Gln Gln Thr 145 150 155 160 Val Ser Ser Val Ile Pro Asp Pro Gln Leu Gly Gln Tyr Asn Tyr Asp 165 170 175 Glu Ile Asp Asp Ala Asp Tyr Thr Gln Lys Gly Gly Ile Gly Arg Val 180 185 190 Ile Gly Asn Asp Ser Thr Gly Asp Ala Tyr Thr Ala His Gly Leu Tyr 195 200 205 Ala Leu Pro Gln Ser Glu Gln Gly Asn Ile Ser Thr Ala Thr Ile Glu 210 215 220 Arg Val Tyr Val Asn Ser Arg Val Thr Asn Asn Ala Ile Ser Gly Val 225 230 235 240 Met Ala Val Asp Thr Ile Glu Arg Leu His Pro Asp Ser His Ile Val 245 250 255 Asp Tyr Gln Asp Asp Ala Gln Val Thr Thr Ala Gly Asp Arg Ile Asn 260 265 270 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Thr 275 280 285 Gly Ser Asn Thr Gly Val Phe Ser Ser Gln Thr Gln Gln Leu Asn Ile 290 295 300 Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Leu 305 310 315 320 Ile Ala Asp Ile Thr Asp Arg Tyr Arg Tyr Phe Ala Leu Trp Asn Gln 325 330 335 Ala Val Asp Ser Tyr Asp Pro Phe Val Arg Val Ile Glu Asn Asp Gly 340 345 350 Tyr Glu Glu Gly Pro Pro Cys Phe Thr Phe Pro Leu Asn Gly Met Gln 355 360 365 Asn Pro Phe Ser Ser Pro Asp Ser Ser Thr Val Val Thr Asn Thr Gly 370 375 380 Ala Thr Ala Ala Gly Thr Gly Tyr Ile Ala Tyr Gly Asn Ile Pro Ser 385 390 395 400 Met Glu Met Asn Leu Thr Ala Asn Leu Gln Arg Thr Phe Leu Trp Ala 405 410 415 Asn Val Ala Met Tyr Leu Pro Asp Arg Leu Lys Ser Ser Pro Ala Asn 420 425 430 Val Asp Leu Pro Thr Asn Thr Gln Ser Tyr Gly Tyr Ile Asn Ser Arg 435 440 445 Ile Pro Leu Pro Asn Ile Ile Asp Thr Trp Thr Asn Ile Gly Ala Lys 450 455 460 Trp Ser Leu Asp Val Met Asp Asn Ile Asn Pro Phe Asn His His Arg 465 470 475 480 Asn Met Gly Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Gly Arg Tyr 485 490 495 Cys Lys Phe Arg Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn 500 505 510 Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr Glu Trp Phe Phe Arg Lys 515 520 525 Asp Pro Asn Met Ile Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Tyr 530 535 540 Asp Gly Ala Ser Ile Thr Tyr Thr Ala Val Asn Leu Tyr Ile Ser Phe 545 550 555 560 Phe Pro Met Asn Tyr Asp Thr Val Ser Glu Leu Glu Leu Met Leu Arg 565 570 575 Asn Ser Thr Asn Asp Gln Asn Phe Ser Asp Tyr Leu Gly Ala Val Asn 580 585 590 Asn Leu Tyr Gln Ile Pro Ala Asn Thr Ser Thr Val Val Val Asn Ile 595 600 605 Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly Trp Ser Phe Asn Arg Val 610 615 620 Lys Ala Thr Glu Thr Pro Met Ile Gly Ser Thr Arg Asp Pro Asn Phe 625 630 635 640 Thr Tyr Ser Gly Thr Ile Pro Ile Leu Asp Gly Thr Phe Tyr Leu Ser 645 650 655 His Thr Phe Gln Lys Val Ser Ile Gln Trp Asp Ser Ser Val Pro Trp 660 665 670 Pro Gly Asp Asp Arg Met Leu Ile Pro Asn Trp Phe Glu Val Lys Arg 675 680 685 Asp Thr Asn Ser Asp Pro Glu Gly Tyr Cys Met Ser Gln Thr Ser Ile 690 695 700 Thr Lys Asp Trp Tyr Phe Val Gln Met Ala Ala Ser Tyr Asn Gln Gly 705 710 715 720 Tyr Gln Gly Tyr Arg Leu Pro Ser Thr Asn Arg Tyr Tyr Gly Phe Ile 725 730 735 Glu Asn Phe Gln Pro Met Ser Arg Gln Ile Pro Glu Tyr Ser Thr Thr 740 745 750 Asp Gly Leu Tyr Asp Leu Tyr Ser Tyr Tyr Val Ala Asn Pro Asp Ser 755 760 765 Leu Pro Ile Trp Asn Asn Cys Gly Leu Gln Pro Pro Thr Ala Pro Pro 770 775 780 Tyr Asn Pro Met Met Arg Asn Ala Gly His Leu Tyr Ala Thr Asn Trp 785 790 795 800 Pro Tyr Pro Leu Thr Gly Lys Asn Ala Val Ser Lys Gln Val Thr Glu 805 810 815 Lys Lys Phe Leu Cys Asp Lys Tyr Met Trp Gln Ile Pro Phe Ser Ser 820 825 830 Asn Phe Leu Asn Met Gly Asn Leu Thr Asp Leu Gly Gln Asn Val Leu 835 840 845 Tyr Ala Asn Ser Ser His Ser Leu Asn Met Ile Phe Ser Val Asp Ala 850 855 860 Met Asp Glu Pro Thr Tyr Leu Phe Leu Leu Phe Gly Val Phe Asp Gln 865 870 875 880 Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala Tyr Met 885 890 895 Arg Leu Pro Phe Ala Ala Gly Ser Ala Ala Ser 900 905 <210> 54 <211> 910 <212> PRT <213> Duck adenovirus <400> 54 Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Asn Ala Lys 1 5 10 15 Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Thr Ala Thr Gln Asn 20 25 30 Tyr Phe Asn Leu Gly Asp Lys Phe Arg Asp Pro Tyr Val Ala Pro Thr 35 40 45 Asn Gly Val Thr Thr Asp Arg Ser Gln Lys Leu His Leu Arg Ile Val 50 55 60 Pro Ile Gln Thr Glu Asp Asn Asp Ser Phe Phe Lys Ala Arg Phe Thr 65 70 75 80 Leu Asn Val Gly Asp Asn Arg Ile Val Asp Met Gly Ser Ser Tyr Phe 85 90 95 Asp Ile Gln Gly Ile Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Arg 100 105 110 Gly Thr Ala Tyr Asn Pro Leu Ala Pro Thr Ser Gly Met Pro Asn Met 115 120 125 Ala Tyr Thr His Ser Asn Asn Thr Thr Tyr Ile Gly Gln Leu Pro Gln 130 135 140 Ile Tyr Ser Val Thr Asp Lys Gly Val Thr Glu Ala Lys Gln Gln Gln 145 150 155 160 Ile Gln Ser Thr Asp Pro Asn Pro Gln Val Gly Gln Ser Tyr Gly Ala 165 170 175 Gly Gly Pro Asp Asp Val Asp Thr Glu Lys Ser Gly Gly Lys Gly Arg 180 185 190 Leu Val Val Gly Thr Ala Gly Asp Ser Gln Val Thr Gly Phe Pro Ala 195 200 205 Tyr Gly Ser Trp Cys Pro Pro Gln Ser Val Thr Gly Asp Ile Asn Thr 210 215 220 Thr Leu Asn Pro Ser Thr Val Tyr Leu Asn Thr Thr Thr Asp Thr Asp 225 230 235 240 Arg Val Thr Gly Leu Val Ala Gly Asp Thr Val Glu Trp Asn Ala Pro 245 250 255 Asp Ala His Tyr Val Asn Tyr Val Ser Asp Met Gln Cys Ser Ala Ala 260 265 270 Gly Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile 275 280 285 Met Tyr Tyr Asn Ser Gly Ser Asn Ala Gly Ser Phe Ser Ser Gln Thr 290 295 300 Gln Gln Leu Asn Val Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu 305 310 315 320 Ser Phe Gln Tyr Leu Ile Ala Glu Leu Thr Asp Arg Tyr Lys His Phe 325 330 335 Ala Leu Trp Asn Gln Ala Val Asp Ser Tyr Asp Lys Phe Val Arg Val 340 345 350 Ile Glu Asn Asp Gly Tyr Glu Glu Gly Pro Pro Ser Leu Ser Phe Pro 355 360 365 Pro His Gly Phe Met Asn Phe Phe Thr Ala Pro Asp Thr Gly Thr Ala 370 375 380 Met Thr Val Ser Asp Asp Thr Ala Thr Lys Thr Ala Asn Thr Thr Ala 385 390 395 400 Ile Phe Gly Tyr Gly Asn Leu Pro Ser Met Glu Ile Asn Leu Thr Ala 405 410 415 Asn Leu Gln Arg Thr Phe Leu Trp Ser Asn Val Ala Met Tyr Leu Pro 420 425 430 Asp Tyr Leu Lys Thr Thr Pro Pro Gly Val Thr Leu Pro Ala Asn Pro 435 440 445 Asn Ser Tyr Ala Tyr Met Asn Gly Arg Leu Pro Leu Pro Asn Ile Ile 450 455 460 Asp Thr Trp Thr Asn Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp 465 470 475 480 Glu Ile Asn Pro Phe Asn His His Arg Asn Leu Gly Leu Lys Tyr Arg 485 490 495 Ser Gln Leu Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val 500 505 510 Pro Gln Lys Phe Phe Ala Leu Arg Asn Leu Leu Leu Leu Ser Gly Thr 515 520 525 Tyr Asn Tyr Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Ile Leu Gln 530 535 540 Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Ser Val Thr Tyr 545 550 555 560 Thr Ser Ile Asn Leu Tyr Val Ala Phe Phe Pro Leu Ala Tyr Asp Thr 565 570 575 Val Ser Glu Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn 580 585 590 Phe Ser Asp Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala 595 600 605 Asn Ser Thr Ser Val Val Val Asn Val Pro Asp Arg Ser Trp Gly Ala 610 615 620 Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Ala Arg Glu Thr Pro Ala 625 630 635 640 Ile Gly Ala Thr Lys Asp Pro Asn Phe Thr Tyr Ser Gly Ser Ile Pro 645 650 655 Leu Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Arg Val Ser 660 665 670 Ile Gln Trp Asp Ser Ser Val Pro Trp Pro Gly Asn Asp Arg Leu Leu 675 680 685 Thr Pro Asn Trp Phe Glu Ile Lys Arg Asn Val Asn Ala Asp Pro Glu 690 695 700 Gly Tyr Thr Met Ser Gln Ser Ser Ile Thr Lys Asp Trp Phe Met Val 705 710 715 720 Gln Met Ala Ala Asn Tyr Asn Gln Ala Tyr Gln Gly Tyr Ser Leu Pro 725 730 735 His Thr Lys Phe Tyr Asp Phe Leu Ser Asn Phe Glu Pro Met Thr Arg 740 745 750 Gln Ile Pro Asp Tyr Ser Lys Tyr Phe Asp Leu Tyr Thr Gln Tyr Leu 755 760 765 Gln Asp Pro Lys Lys Met Pro Ile Trp Asn Asn Ser Gly Val Gln Gln 770 775 780 Met Thr Asn Ser Pro Ala Leu Leu Glu Asn Thr Gly His Leu Tyr Met 785 790 795 800 Ala Asn Trp Pro Tyr Pro Leu Ile Gly Thr Ala Ala Val Glu Ser Gln 805 810 815 Ile Thr Glu Ser Lys Phe Leu Cys Asp Arg Tyr Met Trp Met Ile Pro 820 825 830 Phe Ser Ser Asn Phe Leu Asn Met Gly Thr Leu Thr Asp Leu Gly Gln 835 840 845 Asn Val Leu Tyr Ala Asn Ser Ser His Ser Leu Asn Met Val Phe Asp 850 855 860 Val Asp Pro Met Ala Glu Thr Thr Tyr Leu Leu Leu Leu Phe Gly Val 865 870 875 880 Phe Asp Gln Val Val Ile Asn Gln Pro Thr Arg Ser Gly Ile Ser Val 885 890 895 Ala Tyr Leu Arg Leu Pro Phe Ala Ala Gly Ser Ala Ala Thr 900 905 910 <210> 55 <211> 909 <212> PRT <213> Snake adenovirus <400> 55 Met Glu Pro Gln Arg Glu Phe Phe His Ile Ala Gly Arg Ser Ala Lys 1 5 10 15 Glu Tyr Leu Ser Glu Asn Leu Val Gln Phe Ile Gln Ala Thr Gln Asn 20 25 30 Tyr Phe Asn Ile Gly Glu Lys Phe Arg Asp Pro Tyr Val Ala Pro Ser 35 40 45 Ala Gly Val Thr Thr Asp Arg Ser Gln Lys Leu Gln Leu Arg Val Val 50 55 60 Pro Met Gln Ile Glu Asp Asn Ala Asn Tyr Tyr Lys Ala Arg Phe Thr 65 70 75 80 Leu Asn Val Gly Asp Asn Arg Leu Val Asp Leu Gly Ser Ser Tyr Phe 85 90 95 Asp Ile Lys Gly Thr Leu Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly 100 105 110 Gly Thr Ala Tyr Asn Pro Leu Ala Pro Lys Ser Ala Pro Val Asn Ser 115 120 125 Pro Phe Ile Val Gly Asn Asp Thr His Val Val Ala Gln Leu Pro Gln 130 135 140 Thr Tyr Ala Ala Ala Asn Thr Gly Val Thr Glu Ala Ile Gln Gln Gln 145 150 155 160 Val Ser Asn Val Gln Pro Asn Pro Gln Asp Gly Leu Pro Asn Tyr Ser 165 170 175 Gly Pro Glu Val Val Asp Ala Thr Thr Lys Ala Gly Leu Gly Arg Val 180 185 190 Val Ala Glu Glu Ser Glu Gly Gln Gln Phe Pro Cys Leu Arg Ala Tyr 195 200 205 Ala Ala Pro Gln Thr Ala Ala Gly Asp Val Ser Thr Ala Pro Ile Glu 210 215 220 Lys Thr Tyr Val Asn Thr Thr Asn Val Ala Gly Arg Val Ser Gly Thr 225 230 235 240 Met Ala Thr Asp Val Ile Asp Trp Gln Asn Pro Asp Ala His Phe Val 245 250 255 Asp Tyr Val Asp Asp Gly Arg Ser Thr Ser Ala Gly Asn Arg Pro Asn 260 265 270 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Ile Met Tyr Tyr Asn Ser 275 280 285 Gly Ser Asn Thr Gly Ser Leu Ser Ser Gln Thr Gln Gln Leu Asn Val 290 295 300 Val Leu Asp Leu Asn Asp Arg Asn Ser Glu Leu Ser Tyr Gln Tyr Met 305 310 315 320 Leu Ala Asp Leu Thr Ser Arg Trp His Tyr Phe Ala Leu Trp Asn Gln 325 330 335 Ala Val Asp Ser Tyr Asp Arg His Val Arg Ile Ile Glu Asn Asp Gly 340 345 350 Tyr Glu Glu Gly Pro Pro Asn Leu Ser Phe Pro Ile Gln Gly Ile Gln 355 360 365 Asn Pro Phe Ser Pro Ser Ser Val Gly Thr Glu Met Thr Val Asn Thr 370 375 380 Ala Asn Gln Thr Ala Ala Ala Thr Ala Asn Thr Val Ala His Ile Gly 385 390 395 400 Tyr Gly Asn Ile Pro Ala Val Glu Met Asn Leu Pro Ala Asn Leu Arg 405 410 415 Arg Thr Phe Leu Tyr Ala Asn Val Ala Met Tyr Leu Pro Asp Thr Tyr 420 425 430 Lys Phe Thr Pro Pro Asn Ile Asp Leu Pro Ala Asn His Leu Ser Tyr 435 440 445 Gly Tyr Met Asn Gly Arg Leu Pro Leu Pro Asn Ile Ile Asp Thr Trp 450 455 460 Thr Asp Ile Gly Ala Arg Trp Ser Leu Asp Val Met Asp Thr Val Asn 465 470 475 480 Pro Phe Asn His His Arg Asn Thr Gly Leu Lys Tyr Arg Ser Gln Leu 485 490 495 Leu Gly Asn Gly Arg His Cys Asn Phe His Ile Gln Val Pro Gln Lys 500 505 510 Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Asn Tyr 515 520 525 Glu Trp Tyr Phe Arg Lys Asp Pro Asn Met Val Leu Gln Ser Thr Leu 530 535 540 Gly Asn Asp Leu Arg Glu Asp Gly Ala Gln Ile Thr Tyr Asn Gln Val 545 550 555 560 Asn Leu Tyr Val Ser Phe Phe Pro Met Asn Tyr Asp Thr Gln Ser Glu 565 570 575 Leu Glu Leu Met Leu Arg Asn Ala Thr Asn Asp Gln Asn Phe Ser Asp 580 585 590 Tyr Leu Gly Ala Val Asn Asn Leu Tyr Gln Ile Pro Ala Gly Ser Asn 595 600 605 Thr Val Val Val Asn Ile Pro Asp Arg Ser Trp Gly Ala Phe Arg Gly 610 615 620 Trp Ser Phe Thr Arg Leu Lys Val Thr Glu Thr Pro Arg Ile Gly Ala 625 630 635 640 Thr Gln Asp Pro Asn Phe Glu Tyr Ser Gly Thr Ile Pro Tyr Leu Asp 645 650 655 Gly Thr Phe Tyr Leu Ser His Thr Phe Gln Arg Cys Ser Ile Gln Trp 660 665 670 Asp Ser Ser Val Pro Trp Pro Gly Asn Asp Arg Leu Leu Val Pro Asn 675 680 685 Trp Phe Glu Ile Lys Asp Pro Pro Asn Gln Asp Pro Glu Gly Tyr Asn 690 695 700 Thr Met Gln Ser Asn Leu Thr Lys Asp Phe Phe Phe Thr Gln Met Ala 705 710 715 720 Ala Ser Tyr Asn Gln Gly Tyr Gln Gly Phe Ser Tyr Pro Ser Cys Thr 725 730 735 Lys His Tyr Gly Phe Ile Asn Asn Phe Glu Pro Met Ser Arg Gln Val 740 745 750 Pro Val Tyr Asp Ala Thr His Pro Asn Leu Met Ala Ala Tyr Leu Asn 755 760 765 Asn Pro Ala Thr Met Pro Ile Trp Asn Asn Cys Gly Phe Gln Gln Lys 770 775 780 Thr Ser Thr Asn Ala Leu Leu Glu Arg Cys Gly His Ala Tyr Val Ala 785 790 795 800 Asn Trp Pro Phe Pro Leu Thr Gly Arg Asp Ala Leu Pro Asn Gln Thr 805 810 815 Thr Glu Lys Lys Phe Leu Val Asp Asn Tyr Leu Trp Gln Ile Pro Phe 820 825 830 Ser Ser Asn Phe Leu Asn Met Gly Thr Leu Thr Asp Leu Gly Gln Asn 835 840 845 Val Met Tyr Ala Asn Ser Ser His Ser Leu Asn Met Gln Phe Thr Val 850 855 860 Asp Pro Met Asn Glu Pro Thr Tyr Leu Leu Leu Leu Phe Gly Val Phe 865 870 875 880 Asp Gln Val Val Val Asn Gln Pro Thr Arg Ser Gly Ile Ser Val Ala 885 890 895 Tyr Leu Arg Leu Pro Phe Ala Ser Gly Ser Ala Ala Thr 900 905 <210> 56 <211> 906 <212> PRT <213> Turkey adenovirus 3 <400> 56 Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala 1 5 10 15 Gly Pro Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asn Phe Ile 20 25 30 Ser Ser Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr 35 40 45 Ile Val Ala Pro Thr Lys Gly Val Thr Thr Glu Gln Ser Gln Lys Leu 50 55 60 Gln Val Lys Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe 65 70 75 80 Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Asn Ile Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser 115 120 125 Ala Gln Phe Asn Asn Ile Lys Thr Val Gly Gly Lys Thr Tyr Leu Thr 130 135 140 Ala Gln Ala Thr Lys Phe Phe Ser Thr Ser Gly Asn Gly Cys Ala Ala 145 150 155 160 Ala Asn Thr Glu Ala Ser Ser Phe Thr Asn Leu Val Pro Ser Pro Asn 165 170 175 Thr Gly Ser Ala Glu Ser Ser Phe Asp Pro Thr Thr Glu Gly Ala Ser 180 185 190 Cys Arg Ala Ile Thr Leu Gly Ser Ser Val Thr Asp Ala Thr Cys Tyr 195 200 205 Gly Ala Tyr Thr Pro Ile Gln Asn Ala Asn Gly Ser Ile Leu Pro Pro 210 215 220 Ser Val Thr Pro Asp Lys Lys Phe Ala Asp Ala Gly Lys Ser Gly Ser 225 230 235 240 Val Thr Cys Thr Ala Ala Ile Cys Cys Asp Asn Val Thr Val Gln Tyr 245 250 255 Pro Asp Thr Arg Ile Val Ala Tyr Asp Ser Thr Asp Lys Ile Ala Thr 260 265 270 Arg Met Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile 275 280 285 Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu Ala Thr 290 295 300 Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr 305 310 315 320 Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Asn His 325 330 335 Tyr Tyr Ser Gln Trp Asn Gln Pro Val Asp Asp Tyr Asp Leu Asn Val 340 345 350 Arg Val Leu Thr Asn Ile Gly Tyr Glu Glu Gly Pro Pro Gly Tyr Cys 355 360 365 Tyr Pro Ser Thr Gly Met Gly Asn Tyr Pro Asn Thr Val Met Ser Val 370 375 380 Gly Thr Leu Val Asp Asn Asn Gly Thr Thr Ala Thr Thr Thr Ser Asn 385 390 395 400 Thr Val Ala Val Met Gly Phe Gly Ser Val Pro Thr Met Glu Ile Asn 405 410 415 Val Gln Ala Tyr Leu Gln Lys Cys Trp Met Tyr Ala Asn Ile Ala Glu 420 425 430 Tyr Leu Pro Asp Lys Tyr Lys Lys Ala Ile Gln Gly Thr Ser Glu Thr 435 440 445 Asp Pro Thr Thr Tyr Ser Tyr Met Asn Ser Arg Leu Pro Asn Val Asn 450 455 460 Met Ala Asp Leu Phe Thr His Ile Gly Gly Arg Tyr Ser Leu Asp Val 465 470 475 480 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Arg Gly Leu Gln 485 490 495 Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Asn Val Arg Phe His Ile 500 505 510 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 515 520 525 Gly Thr Tyr Ser Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu Val 530 535 540 Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala Ser Ile 545 550 555 560 Gln Leu Ala Val Ile Ser Leu Tyr Ala Ser Phe Phe Pro Met Asp His 565 570 575 Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln Asn Asp 580 585 590 Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Leu Val 595 600 605 Pro Ala Asn Gln Thr Asn Val Gln Ile Glu Ile Pro Ser Arg Ala Trp 610 615 620 Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Thr Ala Glu Thr 625 630 635 640 Pro Ala Val Trp Ser Thr Tyr Asp Leu Asn Phe Lys Tyr Ser Gly Ser 645 650 655 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Ser 660 665 670 Met Ser Ile Leu Phe Asp Ser Ala Ile Thr Trp Pro Gly Asn Asp Arg 675 680 685 Met Leu Val Pro Asn Phe Phe Glu Ile Lys Arg Glu Ile Asp Thr Glu 690 695 700 Gly Tyr Thr Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Tyr Leu Ile 705 710 715 720 Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser Phe Pro 725 730 735 Ala Asp Lys Val Tyr Arg Gln Tyr Asp Phe Met Ser Asn Phe Asp Ser 740 745 750 Met Ser Val Gln Val Pro Arg Ser Gly Leu Ala Phe Leu Phe Asn Glu 755 760 765 Asn Tyr Asn Leu Ile Val Asn Asn Ser Gly Phe Leu Pro Ser Arg Thr 770 775 780 Ala Pro Ile Ala Gly Val Asn Glu Gly His Pro Tyr Pro Ala Asn Trp 785 790 795 800 Pro Ala Pro Leu Ile Gly Asn Ser Pro Asp Ser Val Val Thr Val Arg 805 810 815 Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr Ile Pro Phe Ser Ser Asn 820 825 830 Phe Met Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr 835 840 845 Thr Glu Ser Ala His Ser Leu Gln Ile Thr Phe Asn Val Asp Pro Met 850 855 860 Pro Glu Pro Thr Tyr Ile Tyr Leu Leu Tyr Ser Val Phe Asp Cys Val 865 870 875 880 Arg Val Asn Gln Pro Asn Lys Asn Tyr Leu Ser Ala Ala Tyr Phe Arg 885 890 895 Thr Pro Phe Ala Thr Gly Thr Ala Ser Val 900 905 <210> 57 <211> 906 <212> PRT <213> Turkey adenovirus A <400> 57 Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala 1 5 10 15 Gly Pro Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asn Phe Ile 20 25 30 Ser Ser Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr 35 40 45 Ile Val Ala Pro Thr Lys Gly Val Thr Thr Glu Gln Ser Gln Lys Leu 50 55 60 Gln Val Lys Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe 65 70 75 80 Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Asn Ile Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser 115 120 125 Ala Gln Phe Asn Asn Ile Lys Thr Val Gly Gly Lys Thr Tyr Leu Thr 130 135 140 Ala Gln Ala Thr Lys Phe Phe Ser Thr Ser Gly Asn Gly Cys Ala Ala 145 150 155 160 Ala Asn Thr Glu Ala Ser Ser Phe Thr Asn Leu Val Pro Ser Pro Asn 165 170 175 Thr Gly Ser Ala Glu Ser Ser Phe Asp Pro Thr Thr Glu Gly Ala Ser 180 185 190 Cys Arg Ala Ile Thr Leu Gly Ser Ser Val Thr Asp Ala Thr Cys Tyr 195 200 205 Gly Ala Tyr Thr Pro Ile Gln Asn Ala Asn Gly Ser Ile Leu Pro Pro 210 215 220 Ser Val Thr Pro Asp Lys Lys Phe Ala Asp Ala Gly Lys Ser Gly Ser 225 230 235 240 Val Thr Cys Thr Ala Ala Ile Cys Cys Asp Asn Val Thr Val Gln Tyr 245 250 255 Pro Asp Thr Arg Ile Val Ala Tyr Asp Ser Thr Asp Lys Ile Ala Thr 260 265 270 Arg Met Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile 275 280 285 Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu Ala Thr 290 295 300 Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr 305 310 315 320 Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Asn His 325 330 335 Tyr Tyr Ser Gln Trp Asn Gln Ala Val Asp Asp Tyr Asp Leu Asn Val 340 345 350 Arg Val Leu Thr Asn Ile Gly Tyr Glu Glu Gly Pro Pro Gly Tyr Cys 355 360 365 Tyr Pro Ser Thr Gly Met Gly Asn Tyr Pro Asn Thr Val Met Ser Val 370 375 380 Gly Thr Leu Val Asp Asn Asn Gly Thr Thr Ala Thr Thr Thr Ser Asn 385 390 395 400 Thr Val Ala Val Met Gly Phe Gly Ser Val Pro Thr Met Glu Ile Asn 405 410 415 Val Gln Ala Tyr Leu Gln Lys Cys Trp Met Tyr Ala Asn Ile Ala Glu 420 425 430 Tyr Leu Pro Asp Lys Tyr Lys Lys Ala Ile Gln Gly Thr Ser Glu Thr 435 440 445 Asp Pro Thr Thr Tyr Ser Tyr Met Asn Ser Arg Leu Pro Asn Val Asn 450 455 460 Met Ala Asp Leu Phe Thr His Ile Gly Gly Arg Tyr Ser Leu Asp Val 465 470 475 480 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Arg Gly Leu Gln 485 490 495 Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Asn Val Arg Phe His Ile 500 505 510 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 515 520 525 Gly Thr Tyr Ser Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu Val 530 535 540 Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala Ser Ile 545 550 555 560 Gln Phe Ser Ser Ile Ser Leu Tyr Ala Ser Phe Phe Pro Met Asp His 565 570 575 Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln Asn Asp 580 585 590 Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Leu Val 595 600 605 Pro Ala Asn Gln Thr Asn Val Gln Ile Glu Ile Pro Ser Arg Ala Trp 610 615 620 Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Thr Ala Glu Thr 625 630 635 640 Pro Ala Val Trp Ser Thr Tyr Asp Leu Asn Phe Lys Tyr Ser Gly Ser 645 650 655 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Asn Ser 660 665 670 Met Ser Ile Leu Phe Asp Ser Ala Ile Thr Trp Pro Gly Asn Asp Arg 675 680 685 Met Leu Val Pro Asn Phe Phe Glu Ile Lys Arg Glu Ile Asp Thr Glu 690 695 700 Gly Tyr Thr Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Tyr Leu Ile 705 710 715 720 Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser Phe Pro 725 730 735 Ala Asp Lys Val Tyr Arg Gln Tyr Asp Phe Met Ser Asn Phe Asp Ser 740 745 750 Met Ser Val Gln Val Pro Arg Ser Gly Leu Ala Phe Leu Phe Asn Glu 755 760 765 Asn Tyr Asn Leu Ile Val Asn Asn Ser Gly Phe Leu Pro Ser Arg Thr 770 775 780 Ala Pro Ile Ala Gly Val Asn Glu Gly His Pro Tyr Pro Ala Asn Trp 785 790 795 800 Pro Ala Pro Leu Ile Gly Asn Ser Pro Asp Ser Val Val Thr Val Arg 805 810 815 Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr Ile Pro Phe Ser Ser Asn 820 825 830 Phe Met Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr 835 840 845 Thr Glu Ser Ala His Ser Leu Gln Ile Thr Phe Asn Val Asp Pro Met 850 855 860 Pro Glu Pro Thr Tyr Ile Tyr Leu Leu Tyr Ser Val Phe Asp Cys Val 865 870 875 880 Arg Val Asn Gln Pro Asn Lys Asn Tyr Leu Ser Ala Ala Tyr Phe Arg 885 890 895 Thr Pro Phe Ala Thr Gly Thr Ala Ser Val 900 905 <210> 58 <211> 912 <212> PRT <213> Raptor adenovirus A <400> 58 Met Asp Ile Ser Asn Ala Thr Pro Lys Leu Asp Ile Phe His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asp Phe Ile 20 25 30 Thr Asn Thr Glu Thr Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr 35 40 45 Ile Val Ala Pro Thr Lys Asn Val Thr Thr Glu Gln Ser Gln Arg Leu 50 55 60 Gln Val Arg Ile Val Pro Thr Leu Thr Gln Asp Leu Glu Asn Ser Phe 65 70 75 80 Thr Ala Arg Phe Thr Ile Ala Val Gly Asp Gly Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Arg Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Cys Gly Thr Ala Tyr Asn Pro Leu Ala Pro Arg Ser 115 120 125 Ala Gln Tyr Asn Asn Ile Arg Lys Val Gly Asn Thr Thr Val Leu Thr 130 135 140 Ala Gln Ala Ser Asn Leu Tyr Thr Ile Ala Ser Ser Gln Asn Gly Ala 145 150 155 160 Ala Ala Ala Asn Thr Val Ala Asn Asp Phe Ser Asn Ile Val Pro Ser 165 170 175 Pro Asn Thr Gly Ile Thr Glu Ser Thr Val Asp Asn Thr Thr Gln Gly 180 185 190 Gly Ser Gly Arg Ala Val Ile Leu Pro Asp Glu Phe Pro Glu Thr Thr 195 200 205 Ala Tyr Gly Ala Tyr Ala Ser Pro Thr Ser Val Asp Gly Gly Gln Leu 210 215 220 Pro Ala Ser Lys Ala Ile Gln Lys Lys Tyr Ala Asp Ala Gly Lys Ser 225 230 235 240 Gly Asn Val Lys Val Thr Ser Ala Phe Ala Gly Glu Glu Leu Asn Val 245 250 255 Ile Tyr Pro Asp Thr Arg Ile Val Ala Tyr Asp Asn Thr Ala Lys Leu 260 265 270 Ala Thr Arg Met Gly Ser Arg Pro Asn Phe Ile Gly Phe Arg Asp Asn 275 280 285 Phe Ile Gly Ile Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Ser Leu 290 295 300 Ala Thr Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg 305 310 315 320 Asn Thr Glu Leu Ser Tyr Gln Trp Leu Leu Asn Asp Leu Met Ser Arg 325 330 335 Gln His Tyr Phe Thr Gln Trp Asn Gln Ala Val Asp Asp Tyr Asp Leu 340 345 350 Asn Val Arg Val Leu Cys Asn Thr Gly Tyr Glu Glu Gly Pro Pro Gly 355 360 365 Gln Val Tyr Pro Ile Thr Gly Met Gly Asn Tyr Pro Ala Asn Val Leu 370 375 380 Lys Val Gly Lys Met Val Thr Asn Thr Gly Ser Asp Ala Asn Thr Val 385 390 395 400 Ser Asn Thr Leu Ser Ile Val Gly Phe Gly Ser Val Pro Ala Trp Glu 405 410 415 Met Asn Met Gln Ala Gln Leu Gln Arg Ser Trp Leu Tyr Ser Asn Ile 420 425 430 Ala Glu Tyr Leu Pro Asp Thr Leu Lys Tyr Ser Ala Pro Leu Ala Leu 435 440 445 Asp Glu Asp Pro Thr Thr Tyr Asn Tyr Met Asn Thr Arg Leu Pro Asn 450 455 460 Val Asn Val Val Asp Leu Phe Thr Asn Ile Gly Gly Arg Tyr Ser Leu 465 470 475 480 Asp Ile Met Asp Asn Gln Asn Pro Phe Asn His His Lys Asn Arg Gly 485 490 495 Leu Gln Tyr Arg Ser Gln Ile Leu Gly Asn Gly Arg Val Cys Asp Phe 500 505 510 His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu 515 520 525 Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn 530 535 540 Leu Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Lys Asp Gly Ala 545 550 555 560 Val Ile Glu Tyr Thr Asn Ile Asn Leu Tyr Ala Ser Phe Phe Pro Met 565 570 575 Asp His Ala Thr Cys Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Gln 580 585 590 Asn Asp Gln Thr Phe Met Asp Tyr Leu Gly Ala Lys Asn Asn Leu Tyr 595 600 605 Val Val Pro Pro Asp Val Ser Asn Leu Gln Ile Glu Ile Pro Ser Arg 610 615 620 Ser Trp Thr Ala Phe Arg Gly Trp Ser Phe Asn Arg Met Lys Ala Ser 625 630 635 640 Glu Thr Pro Ala Val Trp Ser Thr Tyr Asp Val Asn Phe His Tyr Ser 645 650 655 Gly Ser Ile Pro Tyr Leu Asp Ser Thr Phe Tyr Leu Ser His Thr Phe 660 665 670 Asn Ser Leu Ala Ile Thr Phe Asp Ser Ala Val Pro Trp Pro Gly Asn 675 680 685 Asp Arg Leu Leu Leu Pro Asn Phe Phe Glu Ile Lys Arg Asn Tyr Asp 690 695 700 Ser Glu Gly Tyr Cys Thr Ser Gln Ser Asn Met Thr Lys Asp Trp Trp 705 710 715 720 Leu Ile Gln Met Ser Ala Asn Tyr Asn Gln Gly Tyr His Gly Tyr Ser 725 730 735 Tyr Pro Ala Asp Lys Thr Tyr Arg Gln Tyr Asp Phe Ile Ser Asn Phe 740 745 750 Asp Pro Met Ser Ile Gln Val Pro Ala Asn Ser Ile Asn Leu Ile Ser 755 760 765 Pro Ser Val Gln Ser Ser Ser Lys Asn Ala Ile Trp Asn Asn Ser Gly 770 775 780 Tyr Val Ala Pro Arg Asp Lys Thr Leu Ala Thr Pro Asn Gln Gly His 785 790 795 800 Pro Tyr Pro Ala Asn Trp Pro Ala Pro Leu Ile Gly Asp Tyr Asn Val 805 810 815 Ser Met Arg Thr Val Arg Lys Phe Leu Cys Asp Lys Tyr Leu Trp Thr 820 825 830 Ile Pro Phe Ser Ser Asn Phe Met Asn Met Gly Glu Leu Thr Asp Leu 835 840 845 Gly Gln Ser Leu Leu Tyr Thr Glu Ser Ala His Ser Leu Gln Ile Ser 850 855 860 Phe Asn Leu Asp Pro Met Pro Glu Thr Thr Tyr Val Tyr Met Leu Tyr 865 870 875 880 Ser Val Phe Asp Cys Val Arg Val Asn Gln Pro Asn Lys Asn Tyr Val 885 890 895 Ser Ala Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Thr Ala Ser Ala 900 905 910 <210> 59 <211> 901 <212> PRT <213> Great tit adenovirus 1 <400> 59 Met Asp Ile Ser Asn Gly Thr Pro Lys Leu Asp Ile Phe His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Val Asp Phe Ile 20 25 30 Thr Asn Thr Glu Ser Tyr Phe Pro Ile Asn Lys Lys Phe Arg Glu Thr 35 40 45 Ile Val Ala Pro Thr Lys Asn Val Thr Thr Glu Gln Ser Gln Arg Leu 50 55 60 Gln Val Arg Ile Val Pro Thr Leu Thr Gln Asp Leu Glu His Ser Tyr 65 70 75 80 Thr Ala Arg Phe Thr Val Ala Val Gly Asp Gly Arg Val Leu Asp Met 85 90 95 Gly Ser Pro Tyr Phe Asp Ile Arg Gly Thr Ile Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Gln Gly Thr Ala Phe Asn Pro Leu Ala Pro Arg Ser 115 120 125 Ala Met Phe Asn Asn Ile Arg Lys Ile Asp Asn Thr Thr Ile Leu Thr 130 135 140 Ala Gln Ala Ser His Tyr Tyr Asp Val Ser Ser Gly Asn Gly Cys Ala 145 150 155 160 Glu Ala Gln Asn Glu Ala Asn Arg Phe Ser Gly Ile Val Pro Ser Pro 165 170 175 Asn Val Gly Leu Ser Glu Ser Thr Met Asp His Arg Ser Ser Gly Ala 180 185 190 Ser Gly Arg Val Val Leu Leu Ala Asp Asn Lys Glu Ala Thr Ala Tyr 195 200 205 Gly Ala Phe Ala Pro Ala Lys Gln Leu Asn Gly Ser Gln Leu Gly Val 210 215 220 Gly Thr Ala Ile Gln Pro Arg Phe Thr Asn Ala Gly Lys Glu Gly Asn 225 230 235 240 Leu Thr Cys Thr Gly Ala Phe Ala Gly Glu Glu Ile Glu Val Tyr Tyr 245 250 255 Pro Asp Thr Arg Ile Val Met Trp Asp Asp Asp Thr Lys Ile Ala Val 260 265 270 Arg Met Gly Lys Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile 275 280 285 Gly Leu Met Tyr Tyr Asp Asn Gly Ala Leu Ser Gly Ser Leu Ala Thr 290 295 300 Glu Thr Gly Asp Ile Asn Leu Val Glu Gln Leu Gln Asp Arg Asn Thr 305 310 315 320 Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg Gln His 325 330 335 Tyr Tyr Thr Gln Trp Asn Gln Ala Val Asp Asp Tyr Glu Leu Gly Ile 340 345 350 Arg Val Leu Thr Asn Thr Gly Tyr Glu Glu Gly Pro Pro Ser Phe Ser 355 360 365 Phe Pro Ser Leu Gly Met Gly Asn Tyr Pro Tyr Leu Gly Leu Asp Gly 370 375 380 Gly Ile Met Val Glu Asn Asn Gly Ala Ala Ala Thr Asp Ile Ala Asn 385 390 395 400 Thr Ala Ala Gly Ile Gly Phe Gly Ser Val Pro Ser Met Glu Leu Asn 405 410 415 Leu His Ala Tyr Ile Gln Arg Ser Trp Met Tyr Ser Asn Ile Ala Glu 420 425 430 Tyr Leu Pro Asp Asn Leu Lys Tyr Asp Val Pro Gly Leu Pro Pro Val 435 440 445 Pro Ala Ala Asn Thr Tyr Asn Tyr Leu Asn Ala Arg Leu Pro His Val 450 455 460 Asn Val Val Asp Leu Phe Thr His Leu Gly Gly Arg Tyr Ser Leu Asp 465 470 475 480 Val Met Asp Asn Gln Asn Pro Phe Asn His His Lys Asn Arg Gly Leu 485 490 495 Gln Tyr Arg Ser Gln Ile Leu Gly Asn Ala Arg Lys Val Asp Phe His 500 505 510 Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Thr 515 520 525 Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys Asp Pro Asn Leu 530 535 540 Val Leu Gln Ser Thr Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala Ser 545 550 555 560 Val Gln Phe Thr Ser Ile Thr Leu Phe Ala Ser Phe Phe Pro Met Asp 565 570 575 His Ala Thr Ala Ser Glu Leu Ile Leu Met Leu Arg Asn Asp Thr Asn 580 585 590 Asp Gln Thr Phe Met Asp Tyr Met Gly Ala Lys Asn Asn Leu Tyr Val 595 600 605 Val Pro Pro Asn Thr Ser Asn Leu Gln Val Glu Ile Pro Ser Arg Ala 610 615 620 Trp Thr Gly Phe Arg Gly Trp Ser Phe Asn Arg Ile Lys Ala Gln Glu 625 630 635 640 Thr Pro Ala Ile Trp Ser Thr Tyr Asp Val Asn Phe Lys Tyr Ser Gly 645 650 655 Ser Ile Pro Phe Leu Asp Ser Thr Phe Tyr Leu Gly His Thr Phe Asn 660 665 670 Ser Val Ser Ile Thr Phe Asp Ser Ala Ile Pro Trp Pro Gly Asn Asp 675 680 685 Arg Leu Leu Leu Pro Asn Tyr Phe Gln Ile Gln Arg Arg Gly Pro Asp 690 695 700 Ala Glu Gly Tyr Cys Thr Cys Gln Ser Thr Met Thr Lys Asp Trp Tyr 705 710 715 720 Leu Ile Gln Met Leu Gly Asn Tyr Asn Gln Gly Phe His Gly Tyr Ser 725 730 735 Phe Pro Val Asp Lys Thr Phe Arg Gln Tyr Asp Phe Ile Ala Asn Phe 740 745 750 Asp Pro Met Cys Leu Gln Leu Pro Gln Asn Ile Leu Asp Leu Ser Pro 755 760 765 Ile Ile Val Ser Asn Pro Asp Val Val Arg Asn Asn Ser Gly Tyr Val 770 775 780 Ala Pro Arg Ser Ser Ser Ile Ala Leu Arg Asn Glu Gly His Pro Tyr 785 790 795 800 Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Glu Asp Val Gly Gly Thr 805 810 815 Ser Val Gly Thr Arg Thr Val Arg Lys Phe Leu Cys Asp Lys Tyr Leu 820 825 830 Trp Asn Ile Pro Phe Ser Ser Asn Phe Met Asn Met Gly Glu Leu Thr 835 840 845 Asp Leu Gly Gln Ser Leu Leu Tyr Thr Glu Ser Ala His Ser Leu Gln 850 855 860 Leu Ser Phe Glu Leu Glu Pro Met Ser Asp Val Thr Tyr Val Tyr Leu 865 870 875 880 Leu Phe Asn Val Phe Asp Cys Val Arg Val Asn Gln Pro Asn Lys Asn 885 890 895 Tyr Val Ser Ala Ala 900 <210> 60 <211> 920 <212> PRT <213> Frog adenovirus 1 <400> 60 Met Asp Ile Tyr Asn Gly Thr Pro Lys Leu Asp Ile Phe His Ile Ala 1 5 10 15 Gly Arg Asp Ala Ser Glu Tyr Leu Ser Glu Asn Leu Ile Asp Phe Met 20 25 30 Ser Ser Thr Glu Ser Tyr Phe Ser Ile Asn Lys Lys Phe Arg Glu Thr 35 40 45 Ile Val Ala Pro Thr Lys Gly Val Thr Ser Glu Gln Ser Gln Arg Leu 50 55 60 Gln Val Arg Ile Ile Pro Val Gln Thr Gln Asp Ala Glu Gln Thr Tyr 65 70 75 80 Thr Ala Arg Phe Thr Ile Ala Val Gly Glu Gly Arg Val Leu Asp Met 85 90 95 Gly Ser Thr Tyr Phe Asp Ile Arg Gly Ile Val Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Ser 115 120 125 Ala Val Phe Asn Asn Val Lys Thr Val Ser Ile Gly Gly Thr Asn Thr 130 135 140 Ser Val Leu Thr Ala Gln Ala Pro His Leu Tyr Ser Ile Asn Thr Gly 145 150 155 160 Asp Asn Gly Cys Thr Ala Ala Thr Thr Thr Ala Ala Thr Phe Ser Gly 165 170 175 Thr Val Pro Asn Pro Gly Gly Gly Asp Ile Glu Gln Thr Phe Ser Ser 180 185 190 Asn Glu Gly Gly Ala Gly Arg Val Val Asn Ala Gln Gln Asp Thr Gly 195 200 205 Val Tyr Gly Ala Tyr Ala Gln Pro Val Asn Glu Ala Gly Asn Gln Asn 210 215 220 Thr Ala Ala Val Thr Ser Lys Phe Thr Asn Ala Gly Lys Gly Gly Asn 225 230 235 240 Val Thr Cys Thr Ser Ala Phe Ala Val Glu Thr Val Gly Leu Thr Tyr 245 250 255 Pro Asp Thr Arg Val Val Ala Tyr Asp Asp Asp Thr Gly Asp Val Thr 260 265 270 Arg Leu Gly Asn Arg Ile Asn Tyr Ile Gly Phe Arg Asp Asn Phe Val 275 280 285 Gly Leu Met Tyr Tyr Asp Asn Gly Ala His Ser Gly Thr Leu Ala Thr 290 295 300 Glu Thr Gly Asp Ile Asn Ile Val Glu Pro Leu Gln Asp Arg Asn Thr 305 310 315 320 Glu Ile Ser Tyr Gln Tyr Met Leu Ala Asp Leu Met Ser Arg His His 325 330 335 Tyr Phe Ala Met Trp Asn Gln Ala Val Asp Asp Tyr Glu Leu Gly Val 340 345 350 Arg Val Leu Ser Asn His Gly Tyr Glu Glu Ala Met Pro Ala Leu Ser 355 360 365 Phe Asn Thr Thr Gly Met Gly Asn Tyr Gly Gly Ala Ala Leu Leu Ser 370 375 380 Gly Gln Gln Val Thr Ile Asn Ser Asn Ala Ala Thr Ala Val Ala Asn 385 390 395 400 Ser Lys Ala Leu Ile Gly Phe Gly Ala Val Pro Ser Met Glu Met Asn 405 410 415 Leu Gly Ala Gln Leu Ala Arg Ser Trp Leu Phe Ala Asn Val Ala Glu 420 425 430 Tyr Met Pro Asp Asp Leu Lys Val Ser Val Asn Val Pro Gln Arg Tyr 435 440 445 Pro Gln Pro Gly Thr Asn Thr Ser Ser Tyr Asn Tyr Lys Asn Leu Arg 450 455 460 Leu Pro Asn Val Asn Leu Ile Asp Leu Phe Thr Gln Ile Gly Gly Arg 465 470 475 480 Tyr Ser Leu Ser Phe Met Asp Asn Val Asn Pro Phe Asn His His Lys 485 490 495 Asn Arg Gly Leu Lys Tyr Arg Ser Glu Leu Leu Gly Asn Gly Arg Ile 500 505 510 Ala Lys Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Lys 515 520 525 Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Trp Phe Arg Lys 530 535 540 Asp Pro Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Leu 545 550 555 560 Asp Gly Ala Thr Ile Gln Tyr Thr Ser Ile Asn Leu Phe Ala Ser Phe 565 570 575 Phe Pro Met Asp His Ala Thr Cys Asn Asp Leu Ile Leu Met Leu Arg 580 585 590 Asn Glu Thr Asn Asp Gln Ser Phe Met Asp Tyr Met Gly Gly Lys Asn 595 600 605 Asn Leu Tyr Val Val Pro Pro Asn Thr Glu Asn Leu Gln Ile Glu Ile 610 615 620 Pro Ser Arg Thr Trp Glu Ala Phe Arg Gly Trp Ser Phe Asn Arg Leu 625 630 635 640 Lys Thr Ala Glu Thr Pro Ser Val Trp Ser Thr Tyr Asp Val Asn Phe 645 650 655 Lys Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Ser Phe Tyr Leu Ser 660 665 670 His Thr Phe Lys Asn Ile Ala Ile Asn Phe Asp Ser Ala Val Pro Trp 675 680 685 Pro Gly Asn Asp Arg Met Leu Val Pro Asn Tyr Phe Glu Ile Lys Arg 690 695 700 Thr Gly Pro Asp Ser Glu Gly Tyr Cys Val Ala Gln Ser Asn Met Thr 705 710 715 720 Lys Asp Trp Phe Leu Val Gln Met Ser Gly Asn Tyr Asn Gln Gly Tyr 725 730 735 His Gly Tyr Ser Phe Pro Val Asp Lys Thr Tyr Arg Gln Tyr Asp Phe 740 745 750 Ile Ser Asn Phe Asp Pro Met Ser Ile Gln Met Pro Asp Tyr Thr Gln 755 760 765 Gln Asn Ile Tyr Asp Leu Leu Thr Ala Ala Thr Ser Ala Thr Gly Arg 770 775 780 Asp Ile Ile Arg Asn Asn Thr Gly Phe Thr Ala Asn Arg Leu Asn Pro 785 790 795 800 Ser Val Ser Asp His Thr Gly His Pro Tyr Pro Cys Asn Trp Pro Tyr 805 810 815 Pro Leu Ile Gly Ser Gln Ala Val Ala Ser Val Thr His Arg Lys Phe 820 825 830 Leu Cys Asp Lys Tyr Leu Trp Asn Ile Pro Phe Ser Ser Asn Phe Met 835 840 845 Asn Met Gly Glu Leu Thr Asp Leu Gly Gln Ser Leu Leu Tyr Thr Asn 850 855 860 Ser Ser His Ser Ile Gln Ile Ser Ile Glu Leu Glu Pro Met Asn Glu 865 870 875 880 Thr Thr Tyr Val Tyr Met Ile Phe Gly Val Phe Asp Ala Val Arg Val 885 890 895 Asn Gln Pro Asn Lys Asn Ser Val Ser Ala Ala Tyr Phe Arg Thr Pro 900 905 910 Phe Ala Thr Gly Thr Ala Ser Ala 915 920 <210> 61 <211> 944 <212> PRT <213> White sturgeon adenovirus <400> 61 Met Asp Thr Leu Tyr Lys Met Thr Pro Val Gln Thr Met His Ile Met 1 5 10 15 Gly Pro Asp Ala Ser Gln Tyr Leu Ser Glu Gly Ser Lys Ser Leu Pro 20 25 30 Pro Tyr Gly Gln Lys Ile Phe Lys Leu Asn Asn Lys Phe Arg Asp Thr 35 40 45 Val Ala Ala Pro Leu His Val Thr Thr Ser Glu Ser Gln Arg Met Ala 50 55 60 Tyr Met Tyr Ser Pro Gln Thr Ile Asp Asn Ala Asn Gln Ala Tyr Trp 65 70 75 80 Ser Gly Arg Phe Gln Leu Pro Val Pro Asn Asn Arg Ile Leu Asp Met 85 90 95 Gly Gly Ser Phe Phe Asp Ile Glu Gly Thr Leu Asp Arg Gly Lys Ser 100 105 110 Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Cys Leu Ala Pro His Ser 115 120 125 Ser Thr Phe Asn Phe Ile Arg Gly Leu Val Leu Asn Ala Gln Ser Gly 130 135 140 Asn Ala Val Ala Gly Leu Asp Ala Pro Leu Thr Ala Ser Thr Asp Val 145 150 155 160 Gln Ala Ala Gln Thr Ala Met Leu Thr Phe Ser Gly Ser Asn Pro Ser 165 170 175 Pro Asn Val Gly Leu Asn Tyr Thr Pro Asp Pro Ser Gly Leu Leu Phe 180 185 190 Gly Gly Arg Ala Val Val Leu Ser Glu Asp Ala Thr Pro Thr Thr Pro 195 200 205 Ser Tyr Lys Asp Ala Asn Ala Tyr Gly Ala Tyr Met Thr Pro Leu Asp 210 215 220 Ile Tyr Gly Ala Val Asp Asp Asn Val Gly Lys Leu Tyr Thr Cys Arg 225 230 235 240 Ala Gly Val Thr Asp Ala Asn Asn Thr Ala Arg Lys Ile Thr Asp Leu 245 250 255 Trp Ala Cys Asp Asn Thr Gln Val Ser Phe Pro Asp Thr Arg Val Val 260 265 270 Ser Tyr Asn Pro Asp Leu Met Thr Thr Thr Arg Val Gly Asn Arg Met 275 280 285 Asn Cys Val Ala Phe Arg Asp Asn Phe Ile Asn Met Leu Tyr Tyr Asp 290 295 300 Ser Thr Asn Thr Gly Val Leu Glu Ser Phe Ala Asn Gly Asn Asn Val 305 310 315 320 Cys Leu Asp Ser Ala Gln Asp Arg Ser Thr Glu Leu Gly Tyr Gln Tyr 325 330 335 Trp Leu Ala Gly Val Ser Ser Arg Tyr His Asn Tyr Asp Ile Phe Asn 340 345 350 Gln Ser Ile Asp Ser Tyr Asp Lys Arg Val Arg Phe Phe Thr Asn Arg 355 360 365 Gly Phe Asp Asp Gly Leu Pro Ser Tyr Ala Tyr Asn Thr Asn Ala Arg 370 375 380 Ser Gly Leu Thr Thr Gly Lys Met Val Asp Asn Thr Gly Ala Glu Leu 385 390 395 400 Val Ile Gln Asn Asn Ala Ser Ile Glu Thr Gln Ala Leu Val Gly Asn 405 410 415 Gly Lys Met Thr His Tyr Glu Ile Asn Leu Lys Ser Gln Lys Phe Lys 420 425 430 Asn Trp Ile Tyr Thr Asn Ile Ser Glu Tyr Leu Pro Asp Lys Tyr Lys 435 440 445 Thr Pro Ala Ser Val Thr Gly Thr Asn Tyr Pro Pro Phe Pro Thr Pro 450 455 460 Gly Thr Asp Pro Thr Thr Tyr Ala Tyr Lys Asn Leu Met Ile Pro Ser 465 470 475 480 Gln Asn Ile Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Tyr Ser Ile 485 490 495 Pro Gln Thr Asp Asn Val Asn Pro Phe Asn His His Arg Asn Tyr Gly 500 505 510 Leu Asn His Arg Ser Met Leu Leu Gly Asn Ser Arg Ile Thr Asn Phe 515 520 525 Ala Ile Gln Val Pro Asn Lys Phe Phe Ala Ile Lys Asn Leu Ala Leu 530 535 540 Leu Pro Gly Asn Tyr Asn Tyr Glu Trp Lys Phe Arg Lys Asp Val Asn 545 550 555 560 Met Val Leu Gln Ser Thr Leu Gly Ile Asp Leu Arg Ala Asp Glu Ala 565 570 575 Thr Ile Asp Tyr Ser Arg Val Lys Leu Tyr Cys Pro Phe Phe Pro Phe 580 585 590 Asn His Lys Asp Val Ala Glu Leu Asp Met Leu Leu Arg Gln Gln Asn 595 600 605 Asn Ser Gln Thr Phe Tyr Asp Pro Leu Asn Ser Arg Ser Gln Phe Ile 610 615 620 Glu Val Pro Ala Gly Ile Thr Asn Ile Ser Val Thr Val Pro Ala Gln 625 630 635 640 Ser Trp Ser Cys Phe Arg Gly Trp Lys Phe Asn Arg Leu Lys Ala Ser 645 650 655 Glu Arg Cys Asn Lys Asn Ala Val Tyr Glu Thr Gly Leu Lys Tyr Ser 660 665 670 Gly Thr Tyr Pro His Ile Asp Gly Thr Tyr Tyr Leu Gly His Thr Phe 675 680 685 Arg Ala Leu Glu Ile Lys Trp Asp Thr Ser Val Pro Trp Pro Gly Asn 690 695 700 Asp Arg Leu Phe Ser Pro Asn Tyr Phe Glu Met Lys Arg Thr Leu Asp 705 710 715 720 Asn Gly Phe Ala Asp Asn Tyr Cys Ile Ala Gln Cys Asp Met Thr Lys 725 730 735 Asp Trp Trp Leu Val Gln Asn Ser Ala Asn Tyr Asn Gln Gly Tyr Gln 740 745 750 Gly Tyr Gln Tyr Pro Ser Ser Lys Thr Tyr Phe Glu Tyr Asp Phe Met 755 760 765 Arg Asn Phe Val Pro Met Ser Arg Gln Val Pro Asn Met Glu Pro Leu 770 775 780 Lys Met Asp Leu Gln Phe Gly Thr Ala Thr Trp Ala Leu Pro Tyr Pro 785 790 795 800 Gly Lys Ser Thr Phe Asn Asn Thr Ile Arg Asn Asn Ser Gly Phe Ile 805 810 815 Ala Pro Arg Asp Ala Met Pro Gln Thr Asp Ala Arg Gly Ala Pro Tyr 820 825 830 Pro Ala Asn Trp Pro Tyr Pro Leu Ile Ser Glu Lys Ala Leu Pro Asp 835 840 845 Gly Gln Ile Met Thr Glu Lys Lys Phe Leu Cys Asp Lys Tyr Leu Trp 850 855 860 Asn Val Pro Phe Ser Ser Asn Phe Phe Asn Met Gly Glu Leu Thr Asp 865 870 875 880 Glu Gly Gln Ser Asn Met Val Val Gln Ser Ala Ser Asn Leu Gln Met 885 890 895 Asn Phe Asn Leu Asp Pro Met Asp Glu Pro Thr Leu Ile His Ile Leu 900 905 910 Tyr Gly Val Phe Asp Cys Val Gln Val Ser Gln Pro Ala Arg Asn Val 915 920 925 Ile Ser Ala Leu Tyr Phe Arg Thr Pro Phe Asn Ile Gly Ala Asn Ala 930 935 940 <210> 62 <211> 942 <212> PRT <213> Fowl adenovirus 1 <400> 62 Met Thr Ala Leu Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln 1 5 10 15 Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp 20 25 30 Leu Gln Gln Phe Ile Ser Ala Thr Gly Ser Tyr Phe Asp Leu Lys Asn 35 40 45 Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu 50 55 60 Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Ile Gln Thr Asp Asp 65 70 75 80 Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Val Asn Val Gly Asp Ser 85 90 95 Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu 100 105 110 Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro 115 120 125 Leu Ala Pro Arg Glu Ala Ile Phe Asn Thr Trp Val Glu Ser Thr Gly 130 135 140 Pro Gln Thr Asn Val Val Gly Gln Met Thr Asn Val Tyr Thr Asn Gln 145 150 155 160 Thr Arg Asn Asp Lys Thr Ala Thr Leu Gln Gln Val Asn Ser Ile Ser 165 170 175 Gly Val Val Pro Asn Val Asn Leu Gly Pro Gly Leu Ser Gln Leu Ala 180 185 190 Ser Arg Ala Asp Val Asp Asn Ile Gly Val Val Gly Arg Phe Ala Lys 195 200 205 Val Asp Ser Ala Gly Val Lys Gln Ala Tyr Gly Ala Tyr Val Lys Pro 210 215 220 Val Lys Asp Asp Gly Ser Gln Ser Leu Asn Gln Thr Ala Tyr Trp Leu 225 230 235 240 Met Asp Asn Gly Gly Thr Asn Tyr Leu Gly Ala Leu Ala Val Glu Asp 245 250 255 Tyr Thr Gln Thr Leu Ser Tyr Pro Asp Thr Val Leu Val Thr Pro Pro 260 265 270 Thr Ala Tyr Gln Gln Val Asn Ser Gly Thr Met Arg Ala Cys Arg Pro 275 280 285 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp 290 295 300 Ser Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met Asn 305 310 315 320 Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr 325 330 335 Met Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn 340 345 350 Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp 355 360 365 Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Leu Pro Asp Gly His 370 375 380 Gly Ala Gly Glu Asp Asn Gly Pro Asp Leu Ser Asn Val Lys Ile Tyr 385 390 395 400 Thr Asn Gly Gln Gln Asp Lys Gly Asn Val Val Ala Gly Thr Val Ser 405 410 415 Thr Gln Leu Asn Phe Gly Thr Ile Pro Ser Tyr Glu Ile Asp Ile Ala 420 425 430 Ala Ala Thr Arg Arg Asn Phe Ile Met Ser Asn Ile Ala Asp Tyr Leu 435 440 445 Pro Asp Lys Tyr Lys Phe Ser Ile Arg Gly Phe Asp Pro Val Thr Asp 450 455 460 Asn Ile Asp Pro Thr Thr Tyr Phe Tyr Met Asn Arg Arg Val Pro Leu 465 470 475 480 Thr Asn Val Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Trp Ser Val 485 490 495 Asp Gln Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly 500 505 510 Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Arg Phe 515 520 525 His Ile Gln Val Pro Gln Lys Tyr Phe Ala Ile Lys Asn Leu Leu Leu 530 535 540 Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn 545 550 555 560 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala 565 570 575 Gln Ile Val Tyr Thr Glu Val Asn Leu Met Ala Asn Phe Met Pro Met 580 585 590 Asp His Asn Thr Ser Asn Gln Leu Glu Leu Met Leu Arg Asn Ala Thr 595 600 605 Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly Ala Lys Asn Ala Leu Tyr 610 615 620 Asn Val Pro Ala Gly Ser Thr Leu Leu Thr Ile Asn Ile Pro Ala Arg 625 630 635 640 Thr Trp Glu Gly Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Ser 645 650 655 Glu Thr Pro Gln Leu Gly Ala Gln Tyr Asp Val Gly Phe Lys Tyr Ser 660 665 670 Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe Tyr Leu Ser His Thr Phe 675 680 685 Arg Ser Met Ser Val Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn 690 695 700 Asp Arg Leu Leu Thr Pro Asn Leu Phe Glu Ile Lys Arg Pro Val Ala 705 710 715 720 Thr Asp Ser Glu Gly Phe Thr Met Ser Gln Cys Asp Met Thr Lys Asp 725 730 735 Trp Phe Leu Val Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly 740 745 750 Tyr Arg Phe Trp Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg 755 760 765 Asn Phe Asp Pro Met Ser Arg Gln Gly Pro Asn Phe Leu Asp Thr Thr 770 775 780 Leu Tyr Asp Leu Val Ser Ser Thr Pro Val Val Asn Asp Thr Gly Ser 785 790 795 800 Gln Pro Ser Gln Asp Asn Val Arg Asn Asn Ser Gly Phe Ile Ala Pro 805 810 815 Arg Ser Trp Pro Val Trp Thr Ala Gln Gln Gly Glu Ala Trp Pro Ala 820 825 830 Asn Trp Pro Tyr Pro Leu Ile Gly Asn Asp Ala Ile Ser Ser Asn Gln 835 840 845 Thr Val Asn Tyr Lys Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Val 850 855 860 Pro Phe Ser Ser Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Pro Met Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Phe 885 890 895 Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr Val Tyr Met Leu Tyr Gly 900 905 910 Val Phe Asp Thr Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala 915 920 925 Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Asn Ala Val 930 935 940 <210> 63 <211> 942 <212> PRT <213> Fowl adenovirus A <400> 63 Met Thr Ala Leu Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln 1 5 10 15 Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp 20 25 30 Leu Gln Gln Phe Ile Ser Ala Thr Gly Ser Tyr Phe Asp Leu Lys Asn 35 40 45 Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu 50 55 60 Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Ile Gln Thr Asp Asp 65 70 75 80 Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Val Asn Val Gly Asp Ser 85 90 95 Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu 100 105 110 Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro 115 120 125 Leu Ala Pro Arg Glu Ala Ile Phe Asn Thr Trp Val Glu Ser Thr Gly 130 135 140 Pro Gln Thr Asn Val Val Gly Gln Met Thr Asn Val Tyr Thr Asn Gln 145 150 155 160 Thr Arg Asn Asp Lys Thr Ala Thr Leu Gln Gln Val Asn Ser Ile Ser 165 170 175 Gly Val Val Pro Asn Val Asn Leu Gly Pro Gly Leu Ser Gln Leu Ala 180 185 190 Ser Arg Ala Asp Val Asp Asn Ile Gly Val Val Gly Arg Phe Ala Lys 195 200 205 Val Asp Ser Ala Gly Val Lys Gln Ala Tyr Gly Ala Tyr Val Lys Pro 210 215 220 Val Lys Asp Asp Gly Ser Gln Ser Leu Asn Gln Thr Ala Tyr Trp Leu 225 230 235 240 Met Asp Asn Gly Gly Thr Asn Tyr Leu Gly Ala Leu Ala Val Glu Asp 245 250 255 Tyr Thr Gln Thr Leu Ser Tyr Pro Asp Thr Val Leu Val Thr Pro Pro 260 265 270 Thr Ala Tyr Gln Gln Val Asn Ser Gly Thr Met Arg Ala Cys Arg Pro 275 280 285 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp 290 295 300 Ser Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met Asn 305 310 315 320 Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr 325 330 335 Met Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn 340 345 350 Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp 355 360 365 Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Leu Pro Asp Gly His 370 375 380 Gly Ala Gly Glu Asp Asn Gly Pro Asp Leu Ser Asn Val Lys Ile Tyr 385 390 395 400 Thr Asn Gly Gln Gln Asp Lys Gly Asn Val Val Ala Gly Thr Val Ser 405 410 415 Thr Gln Leu Asn Phe Gly Thr Ile Pro Ser Tyr Glu Ile Asp Ile Ala 420 425 430 Ala Ala Thr Arg Arg Asn Phe Ile Met Ser Asn Ile Ala Asp Tyr Leu 435 440 445 Pro Asp Lys Tyr Lys Phe Ser Ile Arg Gly Phe Asp Pro Val Thr Asp 450 455 460 Asn Ile Asp Pro Thr Thr Tyr Phe Tyr Met Asn Arg Arg Val Pro Leu 465 470 475 480 Thr Asn Val Val Asp Leu Phe Thr Asn Ile Gly Ala Arg Trp Ser Val 485 490 495 Asp Gln Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly 500 505 510 Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Arg Phe 515 520 525 His Ile Gln Val Pro Gln Lys Tyr Phe Ala Ile Lys Asn Leu Leu Leu 530 535 540 Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn 545 550 555 560 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Ala Asp Gly Ala 565 570 575 Gln Ile Val Tyr Thr Glu Val Asn Leu Met Ala Asn Phe Met Pro Met 580 585 590 Asp His Asn Thr Ser Asn Gln Leu Glu Leu Met Leu Arg Asn Ala Thr 595 600 605 Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly Ala Lys Asn Ala Leu Tyr 610 615 620 Asn Val Pro Ala Gly Ser Thr Leu Leu Thr Ile Asn Ile Pro Ala Arg 625 630 635 640 Thr Trp Glu Gly Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Ser 645 650 655 Glu Thr Pro Gln Leu Gly Ala Gln Tyr Asp Val Gly Phe Lys Tyr Ser 660 665 670 Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe Tyr Leu Ser His Thr Phe 675 680 685 Arg Ser Met Ser Val Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn 690 695 700 Asp Arg Leu Leu Thr Pro Asn Leu Phe Glu Ile Lys Arg Pro Val Ala 705 710 715 720 Thr Asp Ser Glu Gly Phe Thr Met Ser Gln Cys Asp Met Thr Lys Asp 725 730 735 Trp Phe Leu Val Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly 740 745 750 Tyr Arg Phe Trp Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg 755 760 765 Asn Phe Asp Pro Met Ser Arg Gln Gly Pro Asn Phe Leu Asp Thr Thr 770 775 780 Leu Tyr Asp Leu Val Ser Ser Thr Pro Val Val Asn Asp Thr Gly Ser 785 790 795 800 Gln Pro Ser Gln Asp Asn Val Arg Asn Asn Ser Gly Phe Ile Ala Pro 805 810 815 Arg Ser Trp Pro Val Trp Thr Ala Gln Gln Gly Glu Ala Trp Pro Ala 820 825 830 Asn Trp Pro Tyr Pro Leu Ile Gly Asn Asp Ala Ile Ser Ser Asn Gln 835 840 845 Thr Val Asn Tyr Lys Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Val 850 855 860 Pro Phe Ser Ser Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly 865 870 875 880 Gln Asn Pro Met Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Phe 885 890 895 Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr Val Tyr Met Leu Tyr Gly 900 905 910 Val Phe Asp Thr Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala 915 920 925 Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr Gly Asn Ala Val 930 935 940 <210> 64 <211> 948 <212> PRT <213> Fowl adenovirus D <400> 64 Met Ala Ala Phe Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln 1 5 10 15 Tyr Phe His Ile Ala Gly Pro Ser Thr Arg Glu Tyr Leu Ser Glu Asp 20 25 30 Leu Gln Gln Phe Ile Ala Ala Thr Gly Ser Tyr Phe Glu Leu Lys Asn 35 40 45 Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu 50 55 60 Lys Ala Gln Arg Leu Gln Ile Arg Phe Tyr Pro Thr Gln Thr Asp Asp 65 70 75 80 Thr Pro Asn Ser Tyr Arg Val Arg Tyr Ser Leu Asn Val Gly Asp Ser 85 90 95 Trp Val Leu Asp Met Gly Ala Thr Tyr Phe Asp Ile Lys Gly Val Leu 100 105 110 Asp Arg Gly Pro Ser Phe Lys Pro Tyr Gly Gly Thr Ala Tyr Asn Pro 115 120 125 Leu Ala Pro Arg Glu Ala Phe Phe Asn Asn Trp Leu Glu Ser Glu Pro 130 135 140 Asn Lys Thr Val Ile Thr Gly Leu Met Thr Thr Pro Tyr Arg Asn Asp 145 150 155 160 Gln Gly Asn Lys Thr Asn Thr Ala Asp Val Val Asn Ser Val Ser Gly 165 170 175 Val Tyr Pro Asn Pro Asn Leu Gly Pro Cys Ile Ser Glu Met Gly Ala 180 185 190 Leu Asp Asp Ala Thr Ala Asp Leu Val Gly Phe Ala Gly Arg Phe Ala 195 200 205 Lys Val Thr Asn Glu Asn Thr Arg Leu Ala Tyr Gly Ala Tyr Val Lys 210 215 220 Pro Leu Lys Asn Asp Gly Ser Gln Ser Leu Asn Pro Thr Pro Tyr Trp 225 230 235 240 Val Met Asp Lys Thr Asp Ala Lys Tyr Leu Gly Val Met Ala Val Glu 245 250 255 Glu Phe Ser Thr Ser Leu Thr Tyr Pro Asp Ser Leu Leu Ile Pro Pro 260 265 270 Pro Ser Asp Tyr Ser Thr Val Asn Thr Gly Ala Met Lys Ala Asn Arg 275 280 285 Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His 290 295 300 Asp Thr Gly Val Cys Ser Gly Thr Leu Asn Ser Glu Arg Ser Gly Met 305 310 315 320 Asn Val Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln 325 330 335 Tyr Met Leu Ala Asp Met Met Ser Arg His His Tyr Tyr Ala Leu Trp 340 345 350 Asn Gln Ala Val Asp Gln Tyr Asp His Asp Val Arg Val Phe Asn Asn 355 360 365 Asp Gly Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Ser Pro Glu Gly 370 375 380 Thr Gly Tyr Gly Ala Asn Pro Asn Ser Asn Leu Ser Phe Ala Asp Val 385 390 395 400 Lys Val His Gln Asn Gly Ala Gly Asp Lys Gly Asn Glu Ile Asn Thr 405 410 415 Gly Gly Ala Thr Tyr Ser Thr Tyr Leu Thr Val Gly Ser Val Pro Ser 420 425 430 Tyr Glu Ile Asp Leu Ala Ala Ser Gln Arg Arg Asn Phe Ile Val Ser 435 440 445 Asn Ile Ala Asp Tyr Leu Pro Asp Lys Tyr Lys Tyr Asn Ile Asp Gly 450 455 460 Phe Asn Pro Glu Thr Gly Asn Val Asp Pro Thr Thr Tyr Glu Tyr Met 465 470 475 480 Asn Arg Arg Val Pro Leu Thr Asn Val Val Asp Leu Phe Thr Thr Ile 485 490 495 Gly Ala Arg Trp Ser Ile Asp Gln Met Asp Asn Val Asn Pro Phe Asn 500 505 510 His His Arg Asn Trp Gly Leu Lys Tyr Arg Ser Gln Leu Leu Gly Asn 515 520 525 Ser Arg Tyr Cys Arg Phe His Ile Gln Val Pro Gln Lys Tyr Phe Ala 530 535 540 Ile Lys Asn Leu Leu Leu Leu Pro Gly Thr Tyr Thr Tyr Glu Trp Val 545 550 555 560 Leu Arg Lys Asp Pro Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp 565 570 575 Leu Arg Ala Asp Gly Ala Ser Ile Val Tyr Ser Glu Val Asn Leu Met 580 585 590 Ala Asn Phe Met Pro Met Asp His Asn Thr Ser Asn Gln Leu Glu Leu 595 600 605 Met Met Arg Asn Ala Thr Asn Asp Gln Thr Phe Ala Asp Tyr Leu Gly 610 615 620 Ala Lys Asn Ala Leu Tyr Gln Val Pro Ala Gly Ser Thr Ala Leu Thr 625 630 635 640 Ile Asn Ile Pro Ala Arg Thr Trp Glu Gly Met Arg Gly Trp Ser Phe 645 650 655 Thr Arg Val Lys Ala Ser Glu Thr Pro Gln Ile Gly Ala Gln Tyr Asp 660 665 670 Ile Asn Phe Lys Tyr Ser Gly Ser Ile Pro Tyr Ser Asp Gly Thr Phe 675 680 685 Tyr Leu Thr His Thr Phe Arg Asn Met Ser Val Leu Phe Asp Thr Ser 690 695 700 Ile Asn Trp Pro Gly Asn Asp Arg Leu Leu Ala Pro Asn Leu Phe Glu 705 710 715 720 Ile Lys Arg Asn Val Ser Ile Asn Ala Glu Gly Phe Thr Met Ser Gln 725 730 735 Cys Asn Ile Thr Lys Asp Trp Tyr Leu Ile Gln Met Ala Thr Asn Tyr 740 745 750 Asn Tyr Val Phe Asn Gly Tyr Arg Phe Trp Pro Asp Arg Gln Tyr Phe 755 760 765 His Tyr Asp Phe Leu Arg Asn Phe Asp Pro Met Thr Cys Gln Gly Pro 770 775 780 Asn Phe Gln Asp Gln Thr Leu Phe Asp Leu Met Ser Tyr Asp Pro Val 785 790 795 800 Gln Thr Pro Gly Ala Val Gln Thr Asn Gln Asp Ala Ile Arg Asn Asn 805 810 815 Ser Gly Tyr Thr Ala Pro Arg Ser Trp Pro Val Tyr Gly Ala Gln Gln 820 825 830 Gly Glu Ser Trp Pro Ala Asn Trp Pro Tyr Pro Leu Ile Gly Asp Ser 835 840 845 Ser Leu Asn Pro Thr Gln Ile Val Asn Tyr Lys Lys Phe Leu Cys Asp 850 855 860 Asn Tyr Leu Trp Thr Val Pro Phe Ser Ser Asp Phe Met Tyr Met Gly 865 870 875 880 Glu Leu Thr Asp Leu Gly Gln Asn Pro Met Tyr Thr Asn Asn Ser His 885 890 895 Ser Met Val Ile Asn Phe Glu Leu Asp Pro Met Asp Glu Asn Thr Tyr 900 905 910 Val Tyr Met Leu Tyr Gly Val Phe Asp Met Val Arg Val Asn Gln Pro 915 920 925 Glu Arg Asn Val Leu Ala Met Ala Tyr Phe Arg Thr Pro Phe Ala Thr 930 935 940 Gly Asn Ala Val 945 <210> 65 <211> 935 <212> PRT <213> Northern Aplomado falcon adenovirus <400> 65 Met Ala Ala Phe Thr Pro Asp Leu Thr Thr Ala Thr Pro Arg Leu Gln 1 5 10 15 Tyr Phe His Ile Ala Gly Pro Gly Thr Arg Glu Tyr Leu Ser Glu Asp 20 25 30 Leu Gln Gln Phe Ile Ser Ala Thr Ser Ser Tyr Phe Asp Leu Lys Asn 35 40 45 Lys Phe Arg Gln Thr Val Val Ala Pro Thr Arg Asn Val Thr Thr Glu 50 55 60 Lys Ser Gln Arg Leu Gln Ile Arg Tyr Tyr Pro Thr Gln Thr Asp Asp 65 70 75 80 Thr Thr His Gly Tyr Arg Val Arg Tyr Ser Leu Thr Val Gly Asp Ser 85 90 95 Trp Val Leu Asp Met Gly Ser Thr Tyr Phe Asp Ile Lys Gly Phe Ile 100 105 110 Asp Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Pro 115 120 125 Leu Ala Pro Arg Glu Ser Leu Phe Asn Phe Trp Gln Glu Lys Ser Gly 130 135 140 Asn Lys Tyr Val Ser Gly Gln Leu Ser Asn Val Tyr Thr Asn Asp Asn 145 150 155 160 Ser Thr Thr Asn Ala Ser Thr Trp Glu Ser Ala Lys Asp Phe Ser Gln 165 170 175 Thr Ser Pro Asn Pro Asn Val Gly Pro Phe Val Ser Asp Pro Asn Leu 180 185 190 Leu Gly Thr Leu Glu Lys Ile Gly Val Ser Gly Arg Ile Ala Lys Val 195 200 205 Gly Ser Asn Thr Val Pro Leu Thr Tyr Gly Ala Tyr Val Lys Pro Thr 210 215 220 Ser Val Thr Gly Ser Gln Thr Ala Asp Phe Thr Arg Tyr Tyr Ile Met 225 230 235 240 Asp Ser Ala Gly Thr Lys Tyr Gln Gly Ala Val Ala Val Glu Asp Val 245 250 255 Ser His Thr Leu Ser Tyr Pro Asp Thr Leu Arg Ile Ala Pro Ala Ile 260 265 270 Glu Thr Ser Gly Val Asp Ser Gly Ile Ser Lys Ser Leu Arg Pro Asn 275 280 285 Tyr Ile Ala Phe Arg Asp Asn Phe Ile Asn Leu Leu Tyr His Asp Thr 290 295 300 Gly Ala Cys Ser Gly Thr Leu Ser Ser Glu Arg Ser Gly Met Asn Val 305 310 315 320 Val Val Glu Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Tyr Met 325 330 335 Leu Ala Asp Met Met Ser Arg His His Tyr Phe Ala Leu Trp Asn Gln 340 345 350 Ala Val Asp Ser Tyr Asp His Asp Val Arg Val Phe Asn Asn Asp Gly 355 360 365 Tyr Glu Glu Gly Val Pro Thr Tyr Ala Phe Gln Pro Asn Gly Val Gly 370 375 380 Asn Tyr Glu Ala Gly Pro Asp Leu Ser Glu Ser Lys Leu Phe Thr Ile 385 390 395 400 Ser Ser Thr Asn His Asp Lys Glu Thr Asp Gln Asn Ala Thr Met Asn 405 410 415 Ile Ala Trp Gly Pro Val Val Ala Asn Glu Ile Cys Met Ser Ala Ala 420 425 430 Met Lys Arg Asn Phe Ile Met Thr Asn Ile Ala Glu Tyr Leu Pro Asp 435 440 445 Lys Tyr Lys Phe Asn Ile Pro Gly Phe Ser Ala Asp Asn Ala Asp Arg 450 455 460 Arg Ser Tyr Glu Tyr Met Asn His Arg Val Pro Leu Val Asn Val Val 465 470 475 480 Asp Leu Phe Thr Asn Leu Gly Ala Arg Trp Ser Val Asp Gln Met Asp 485 490 495 Asn Val Asn Pro Phe Asn His His Arg Asn Trp Gly Leu Lys Tyr Arg 500 505 510 Ser Gln Leu Leu Gly Asn Ser Arg Tyr Cys Gln Phe His Ile Gln Val 515 520 525 Pro Gln Lys Tyr Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Thr 530 535 540 Tyr Thr Tyr Glu Trp Val Leu Arg Lys Asp Pro Asn Met Val Leu Gln 545 550 555 560 Ser Thr Leu Gly Asn Asp Leu Arg Leu Asp Gly Ala Arg Ile Val Tyr 565 570 575 Gln Glu Val Asn Leu Met Ala Ser Phe Met Pro Met Asp His Asn Thr 580 585 590 Ser Asn Gln Leu Glu Leu Met Met Arg Asn Ala Val Asn Asp Gln Thr 595 600 605 Phe Ala Asp Tyr Leu Gly Ala Lys Ser Ala Leu Tyr Ser Val Pro Ala 610 615 620 Gln Ser Thr Val Leu Thr Ile Asn Val Pro Ala Arg Thr Trp Glu Gly 625 630 635 640 Met Arg Gly Trp Ser Phe Thr Arg Leu Lys Ala Glu Glu Thr Pro Gln 645 650 655 Gln Gly Ala Gln Tyr Asp Ile Asn Phe Arg Tyr Ser Gly Ser Ile Pro 660 665 670 Tyr Gln Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Arg Asn Met Ser 675 680 685 Ile Leu Phe Asp Thr Ser Ile Asn Trp Pro Gly Asn Asp Arg Met Leu 690 695 700 Thr Pro Asn Met Phe Glu Ile Lys Arg Ser Pro Ala Ala Asp Ala Glu 705 710 715 720 Gly Tyr Gly Met Ser Gln Ser Thr Ile Thr Lys Asp Trp Phe Leu Val 725 730 735 Gln Met Ala Thr Asn Tyr Asn Tyr Val Tyr Asn Gly Tyr Arg Phe Trp 740 745 750 Pro Asp Arg His Tyr Phe His Tyr Asp Phe Leu Arg Asn Phe Asp Pro 755 760 765 Met Ser Met Gln Gly Pro Asp Phe Asn Asn Thr Asp Thr Phe Asp Leu 770 775 780 Val Thr Tyr Thr His Gln Ser Pro Thr Arg His Thr Lys Thr Lys Gln 785 790 795 800 Asn Lys Lys Arg Asn Asn Ser Gly Met Val Ala Asp Arg Ala Gly Ala 805 810 815 Pro Phe Asn Lys Arg Gln Gly Gln Leu Trp Pro Ser Asn Trp Pro Tyr 820 825 830 Pro Leu Ile Gly Lys Glu Ser Leu Pro Val Glu Lys Ile Leu Asn Tyr 835 840 845 Arg Lys Phe Leu Cys Asp Asn Tyr Leu Trp Thr Ile Pro Phe Ser Ser 850 855 860 Asp Phe Met Tyr Met Gly Glu Leu Thr Asp Leu Gly Gln Asn Pro Met 865 870 875 880 Tyr Thr Asn Asn Ser His Ser Met Val Ile Asn Leu Glu Met Asp Pro 885 890 895 Met Asp Glu Asn Thr Leu Val Tyr Met Leu Tyr Gly Val Phe Asp Thr 900 905 910 Val Arg Val Asn Gln Pro Glu Arg Asn Val Leu Ala Met Ala Tyr Phe 915 920 925 Arg Thr Pro Phe Ala Thr Gly 930 935 <210> 66 <211> 963 <212> PRT <213> Feline adenovirus <400> 66 Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser Gly 1 5 10 15 Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg 20 25 30 Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro Thr 35 40 45 Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr 50 55 60 Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr Lys 65 70 75 80 Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala 85 90 95 Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr Phe 100 105 110 Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly Ala 115 120 125 Pro Asn Ser Cys Glu Trp Glu Gln Glu Glu Pro Thr Gln Glu Met Ala 130 135 140 Glu Glu Leu Glu Asp Glu Glu Glu Ala Glu Glu Glu Glu Ala Glu Glu 145 150 155 160 Glu Ala Glu Ala Pro Gln Ala Asp Gln Lys Val Lys Lys Thr His Val 165 170 175 Tyr Ala Gln Ala Pro Leu Ala Gly Glu Lys Ile Thr Ala Asn Gly Leu 180 185 190 Gln Ile Val Ser Asp Thr Gln Thr Glu Gly Asn Pro Val Phe Ala Asp 195 200 205 Pro Thr Tyr Gln Pro Glu Pro Gln Val Gly Glu Ser Gln Trp Asn Glu 210 215 220 Ala Glu Ala Thr Ala Ser Gly Gly Arg Val Leu Lys Lys Thr Thr Pro 225 230 235 240 Met Lys Pro Cys Tyr Gly Ser Tyr Ala Arg Pro Thr Asn Lys Asn Gly 245 250 255 Gly Gln Gly Ile Leu Val Ala Asn Asn Gln Gly Ala Leu Glu Ser Lys 260 265 270 Val Glu Met Gln Phe Phe Ala Pro Ser Gly Thr Ala Met Asn Glu Arg 275 280 285 Asn Ala Val Gln Pro Ser Ile Val Leu Tyr Ser Glu Asp Val Asn Met 290 295 300 Glu Thr Pro Asp Thr His Ile Ser Tyr Lys Pro Ser Lys Thr Asp Glu 305 310 315 320 Asn Ser Lys Ala Met Leu Gly Gln Gln Ala Met Pro Asn Arg Pro Asn 325 330 335 Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser 340 345 350 Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala 355 360 365 Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu 370 375 380 Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln 385 390 395 400 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly 405 410 415 Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Ile Gly 420 425 430 Val Thr Asp Thr Tyr Gln Gly Ile Lys Ser Asn Gly Asn Gly Asn Pro 435 440 445 Gln Asn Trp Thr Lys Asn Asp Asp Phe Ala Ala Arg Asn Glu Ile Gly 450 455 460 Val Gly Asn Asn Phe Ala Leu Glu Ile Asn Leu Asn Ala Asn Leu Trp 465 470 475 480 Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr Leu Pro Asp Lys Leu 485 490 495 Lys Tyr Thr Pro Thr Asn Val Glu Ile Ser Pro Asn Pro Asn Ser Tyr 500 505 510 Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu Val Asp Cys Tyr 515 520 525 Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met Asp Asn Val Asn 530 535 540 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 545 550 555 560 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 565 570 575 Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 580 585 590 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser Ser Leu 595 600 605 Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys Phe Asp Ser Ile 610 615 620 Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 625 630 635 640 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 645 650 655 Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 660 665 670 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 675 680 685 Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 690 695 700 Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 705 710 715 720 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ala Ile Thr Phe 725 730 735 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 740 745 750 Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val Ala 755 760 765 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala Asn 770 775 780 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu Ser Tyr Lys Asp 785 790 795 800 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val 805 810 815 Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln Val Gly Ile Leu His 820 825 830 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg 835 840 845 Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro Leu Ile Gly Lys 850 855 860 Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe Leu Cys Asp Arg Thr 865 870 875 880 Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu 885 890 895 Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His Ala Leu 900 905 910 Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr 915 920 925 Val Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg 930 935 940 Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 945 950 955 960 Ala Thr Thr <210> 67 <211> 931 <212> PRT <213> Simian adenovirus 1 <400> 67 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Ala Glu Trp Thr Asn Ser Asp Ser Lys Val Lys Val 130 135 140 Arg Ala Gln Ala Pro Phe Val Ser Ser Tyr Gly Ala Thr Ala Ile Thr 145 150 155 160 Lys Glu Gly Ile Gln Val Gly Val Thr Leu Thr Asp Ser Gly Ser Thr 165 170 175 Pro Gln Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Ile Gly Glu 180 185 190 Leu Gln Trp Asn Ser Asp Val Gly Thr Asp Asp Lys Ile Ala Gly Arg 195 200 205 Val Leu Lys Lys Thr Thr Pro Met Phe Pro Cys Tyr Gly Ser Tyr Ala 210 215 220 Arg Pro Thr Asn Glu Lys Gly Gly Gln Ala Thr Pro Ser Ala Ser Gln 225 230 235 240 Asp Val Gln Asn Pro Glu Leu Gln Phe Phe Ala Ser Thr Asn Val Ala 245 250 255 Asn Thr Pro Lys Ala Val Leu Tyr Ala Glu Asp Val Ser Ile Glu Ala 260 265 270 Pro Asp Thr His Leu Val Phe Lys Pro Thr Val Thr Glu Gly Ile Thr 275 280 285 Ser Ser Glu Ala Leu Leu Thr Gln Gln Ala Ala Pro Asn Arg Pro Asn 290 295 300 Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser 305 310 315 320 Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala 325 330 335 Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Met 340 345 350 Leu Asp Ala Leu Gly Asp Arg Ser Arg Tyr Phe Ser Met Trp Asn Gln 355 360 365 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly 370 375 380 Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Gly Gly Met Ala 385 390 395 400 Val Thr Asp Thr Tyr Ser Pro Ile Lys Val Asn Gly Gly Gly Asn Gly 405 410 415 Trp Glu Ala Asn Asn Gly Val Phe Thr Glu Arg Gly Val Glu Ile Gly 420 425 430 Ser Gly Asn Met Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp 435 440 445 Arg Ser Phe Leu Tyr Ser Asn Ile Gly Leu Tyr Leu Pro Asp Ser Leu 450 455 460 Lys Ile Thr Pro Asp Asn Ile Thr Leu Pro Glu Asn Lys Asn Thr Tyr 465 470 475 480 Gln Tyr Met Asn Gly Arg Val Thr Pro Pro Gly Leu Val Asp Thr Tyr 485 490 495 Val Asn Val Gly Ala Arg Trp Ser Pro Asp Val Met Asp Ser Ile Asn 500 505 510 Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 515 520 525 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys 530 535 540 Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr 545 550 555 560 Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu 565 570 575 Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Arg Phe Asp Ser Ile 580 585 590 Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr 595 600 605 Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp 610 615 620 Tyr Leu Cys Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 625 630 635 640 Ser Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 645 650 655 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser 660 665 670 Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 675 680 685 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Met Phe 690 695 700 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn 705 710 715 720 Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly Tyr Asn Val Ala 725 730 735 Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Ile Gln Met Leu Ser His 740 745 750 Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Asn Tyr Lys Asp 755 760 765 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Ile 770 775 780 Val Asp Ser Thr Ala Tyr Thr Asn Tyr Gln Asp Val Lys Leu Pro Tyr 785 790 795 800 Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Gly Pro Thr Met Arg 805 810 815 Glu Gly Gln Ala Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Ala 820 825 830 Thr Ala Val Pro Ser Leu Thr Gln Lys Lys Phe Leu Cys Asp Arg Val 835 840 845 Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ser Leu 850 855 860 Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 865 870 875 880 Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr 885 890 895 Val Leu Phe Glu Val Phe Asp Val Val Arg Ile His Gln Pro His Arg 900 905 910 Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 915 920 925 Ala Thr Thr 930 <210> 68 <211> 921 <212> PRT <213> Simian adenovirus 7 <400> 68 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Ser Glu Trp Thr Asp Thr Ser Asp Asn Lys Leu Lys 130 135 140 Ala Tyr Ala Gln Ala Pro Tyr Gln Ser Gln Gly Leu Thr Lys Asp Gly 145 150 155 160 Ile Gln Val Gly Leu Val Val Thr Glu Ser Gly Gln Thr Pro Gln Tyr 165 170 175 Ala Asn Lys Val Tyr Gln Pro Glu Pro Gln Ile Gly Glu Asn Gln Trp 180 185 190 Asn Leu Glu Gln Glu Asp Lys Ala Ala Gly Arg Val Leu Lys Lys Asp 195 200 205 Thr Pro Met Phe Pro Cys Tyr Gly Ser Tyr Ala Arg Pro Thr Asn Glu 210 215 220 Gln Gly Gly Gln Ala Lys Asn Gln Glu Val Asp Leu Gln Phe Phe Ala 225 230 235 240 Thr Pro Gly Asp Thr Gln Asn Thr Ala Lys Val Val Leu Tyr Ala Glu 245 250 255 Asn Val Asn Leu Glu Thr Pro Asp Thr His Leu Val Phe Lys Pro Asp 260 265 270 Asp Asp Ser Thr Ser Ser Lys Leu Leu Leu Gly Gln Gln Ala Ala Pro 275 280 285 Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met 290 295 300 Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser 305 310 315 320 Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser 325 330 335 Tyr Gln Leu Met Leu Asp Ala Leu Gly Asp Arg Ser Arg Tyr Phe Ser 340 345 350 Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile 355 360 365 Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu 370 375 380 Gly Gly Met Val Val Thr Asp Asn Tyr Asn Ser Val Thr Pro Gln Asn 385 390 395 400 Gly Gly Ser Gly Asn Thr Trp Gln Ala Asp Asn Thr Thr Phe Ser Gln 405 410 415 Arg Gly Ala Gln Ile Gly Ser Gly Asn Met Phe Ala Leu Glu Ile Asn 420 425 430 Leu Gln Ala Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Ile Gly Leu 435 440 445 Tyr Leu Pro Asp Ser Leu Lys Ile Thr Pro Asp Asn Ile Thr Leu Pro 450 455 460 Glu Asn Lys Asn Thr Tyr Gln Tyr Met Asn Gly Arg Val Thr Pro Pro 465 470 475 480 Gly Leu Ile Asp Thr Tyr Val Asn Val Gly Ala Arg Trp Ser Pro Asp 485 490 495 Val Met Asp Ser Ile Asn Pro Phe Asn His His Arg Asn Ala Gly Leu 500 505 510 Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His 515 520 525 Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu 530 535 540 Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met 545 550 555 560 Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser 565 570 575 Ile Arg Phe Asp Ser Ile Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala 580 585 590 His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn 595 600 605 Asp Gln Ser Phe Asn Asp Tyr Leu Cys Ala Ala Asn Met Leu Tyr Pro 610 615 620 Ile Pro Ala Asn Ala Thr Ser Val Pro Ile Ser Ile Pro Ser Arg Asn 625 630 635 640 Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu 645 650 655 Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly 660 665 670 Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys 675 680 685 Lys Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 690 695 700 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly 705 710 715 720 Glu Gly Tyr Asn Val Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu 725 730 735 Ile Gln Met Leu Ser His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val 740 745 750 Pro Glu Asn Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln 755 760 765 Pro Met Ser Arg Gln Val Val Asp Thr Val Thr Tyr Thr Asp Tyr Lys 770 775 780 Asp Val Lys Leu Pro Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr 785 790 795 800 Met Gly Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Tyr Pro 805 810 815 Tyr Pro Leu Ile Gly Glu Thr Ala Val Pro Ser Leu Thr Gln Lys Lys 820 825 830 Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe 835 840 845 Met Ser Met Gly Ser Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala 850 855 860 Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp 865 870 875 880 Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg 885 890 895 Ile His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr 900 905 910 Pro Phe Ser Ala Gly Asn Ala Thr Thr 915 920 <210> 69 <211> 956 <212> PRT <213> Simian adenovirus 21 <400> 69 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Met Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Phe Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Ser Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Ser Gln Trp Leu Asp Lys Gly Val Thr Thr Thr Asp 130 135 140 Asn Asn Thr Glu Asn Gly Asp Glu Glu Asp Glu Val Ala Glu Glu Gly 145 150 155 160 Glu Glu Glu Lys Gln Ala Thr Tyr Thr Phe Gly Asn Ala Pro Val Lys 165 170 175 Ala Glu Ala Glu Ile Thr Lys Glu Gly Leu Pro Ile Gly Leu Glu Val 180 185 190 Pro Ser Glu Gly Asp Pro Lys Pro Ile Tyr Ala Asp Lys Leu Tyr Gln 195 200 205 Pro Glu Pro Gln Val Gly Glu Glu Ser Trp Thr Asp Thr Asp Gly Thr 210 215 220 Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro Glu Thr Lys Met Lys 225 230 235 240 Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Val Lys Gly Gly Gln 245 250 255 Ala Lys Val Lys Lys Val Glu Glu Gly Lys Val Glu Tyr Asp Ile Asp 260 265 270 Met Asn Phe Phe Asp Leu Arg Ser Gln Lys Thr Gly Leu Lys Pro Lys 275 280 285 Ile Val Met Tyr Ala Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His 290 295 300 Val Val Tyr Lys Pro Gly Ala Ser Asp Ala Ser Ser His Ala Asn Leu 305 310 315 320 Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp 325 330 335 Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 340 345 350 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp 355 360 365 Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp 370 375 380 Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp 385 390 395 400 Pro Asp Val Arg Val Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 405 410 415 Asn Tyr Cys Phe Pro Leu Asp Gly Val Gly Pro Arg Thr Asp Ser Tyr 420 425 430 Lys Gly Ile Glu Thr Asn Gly Asp Glu Asn Thr Thr Trp Lys Asp Leu 435 440 445 Asp Pro Asn Gly Ile Ser Glu Leu Ala Lys Gly Asn Pro Phe Ala Met 450 455 460 Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn 465 470 475 480 Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Thr Asn Val 485 490 495 Thr Leu Pro Glu Asn Lys Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val 500 505 510 Val Pro Pro Ser Leu Val Asp Thr Tyr Val Asn Ile Gly Ala Arg Trp 515 520 525 Ser Leu Asp Ala Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 530 535 540 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val 545 550 555 560 Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Val Lys Asn Leu 565 570 575 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp 580 585 590 Val Asn Met Val Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp 595 600 605 Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe 610 615 620 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 625 630 635 640 Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met 645 650 655 Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro 660 665 670 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys 675 680 685 Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val 690 695 700 Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His 705 710 715 720 Thr Phe Lys Lys Val Ser Ile Met Phe Asp Ser Ser Val Ser Trp Pro 725 730 735 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr 740 745 750 Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp 755 760 765 Trp Phe Leu Val Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly 770 775 780 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg 785 790 795 800 Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Ile Asn Tyr Lys 805 810 815 Asp Tyr Lys Ala Val Ala Val Pro Tyr Gln His Asn Asn Ser Gly Phe 820 825 830 Val Gly Tyr Met Ala Pro Thr Met Arg Gln Gly Gln Ala Tyr Pro Ala 835 840 845 Asn Tyr Pro Tyr Pro Leu Ile Gly Thr Thr Ala Val Thr Ser Val Thr 850 855 860 Gln Lys Lys Phe Leu Cys Asp Arg Thr Met Trp Arg Ile Pro Phe Ser 865 870 875 880 Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu 885 890 895 Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp 900 905 910 Pro Met Asp Glu Pro Thr Leu Leu Tyr Leu Leu Phe Glu Val Phe Asp 915 920 925 Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr 930 935 940 Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 945 950 955 <210> 70 <211> 949 <212> PRT <213> Unknown <220> <223> Unidentified adenovirus <400> 70 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Asn Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Met Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ala Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Phe Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Ser Gln Trp Ile Ala Glu Gly Val Lys Lys Glu Asn 130 135 140 Gly Glu Ser Asp Glu Glu Glu Glu Lys Asn Leu Thr Thr Tyr Thr Phe 145 150 155 160 Gly Asn Ala Pro Val Lys Ala Glu Gly Gly Asp Ile Thr Lys Asp Lys 165 170 175 Gly Leu Pro Ile Gly Ser Glu Ile Thr Asp Gly Glu Ala Lys Pro Ile 180 185 190 Tyr Ala Asp Lys Leu Tyr Gln Pro Glu Pro Gln Val Gly Asp Glu Thr 195 200 205 Trp Thr Asp Thr Asp Gly Thr Ala Glu Lys Tyr Gly Gly Arg Ala Leu 210 215 220 Lys Pro Glu Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro 225 230 235 240 Thr Asn Val Lys Gly Gly Gln Ala Lys Gln Lys Thr Thr Glu Gln Leu 245 250 255 Gln Asn Gln Gln Val Glu Tyr Asp Ile Asp Met Asn Phe Phe Asp Gln 260 265 270 Ala Ser Gln Lys Ala Asn Phe Ser Pro Lys Ile Val Met Tyr Ala Glu 275 280 285 Asn Val Asp Leu Glu Thr Pro Asp Thr His Val Val Tyr Lys Pro Gly 290 295 300 Thr Ser Glu Glu Ser Ser His Ala Asn Leu Gly Gln Gln Ser Met Pro 305 310 315 320 Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met 325 330 335 Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser 340 345 350 Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser 355 360 365 Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser 370 375 380 Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile 385 390 395 400 Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu 405 410 415 Asp Gly Val Gly Val Pro Thr Thr Ser Tyr Lys Ile Ile Glu Pro Asn 420 425 430 Gly Glu Gly Ala Asp Trp Lys Glu Pro Asp Ile Asn Gly Thr Ser Glu 435 440 445 Ile Gly Gln Gly Asn Leu Ser Ala Met Glu Ile Asn Leu Gln Ala Asn 450 455 460 Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp 465 470 475 480 Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Thr Asn 485 490 495 Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Pro Pro Ser Leu Val Asp 500 505 510 Thr Tyr Val Asn Ile Gly Ala Arg Trp Ser Leu Asp Ala Met Asp Asn 515 520 525 Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser 530 535 540 Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro 545 550 555 560 Gln Lys Phe Phe Ala Val Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr 565 570 575 Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu Gln Ser 580 585 590 Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Ser Phe Thr 595 600 605 Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala 610 615 620 Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe 625 630 635 640 Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn 645 650 655 Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 660 665 670 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu 675 680 685 Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr 690 695 700 Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile 705 710 715 720 Met Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr 725 730 735 Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn 740 745 750 Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu 755 760 765 Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr 770 775 780 Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg 785 790 795 800 Gln Val Val Asp Glu Ile Asn Tyr Lys Asp Tyr Lys Ala Val Ala Val 805 810 815 Pro Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Ala Pro Thr 820 825 830 Met Arg Gln Gly Gln Ala Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile 835 840 845 Gly Thr Thr Ala Val Thr Ser Val Thr Gln Lys Lys Phe Leu Cys Asp 850 855 860 Arg Thr Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly 865 870 875 880 Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser Ala His 885 890 895 Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu 900 905 910 Leu Tyr Leu Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro 915 920 925 His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala 930 935 940 Gly Asn Ala Thr Thr 945 <210> 71 <211> 932 <212> PRT <213> Simian adenovirus 3 <400> 71 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Ile Arg Phe Val Pro Val Asp Lys Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Thr Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Ile Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Asn Cys Gln Trp Gln Ser Gly Val Gln Pro Lys Val Asn 130 135 140 Thr Tyr Gly Gln Ala Ala Phe Ile Asn Asp Phe Val Asp Asn Asn Asn 145 150 155 160 Gly His Thr Gly Ile Lys Val Gly Asp Asn Ala Glu Gly Gln Pro Ile 165 170 175 Val Ala Asp Pro Thr Phe Gln Pro Glu Pro Gln Thr Gly Gly Leu Asp 180 185 190 Thr Gln Trp Asn Thr Val Pro Asn Thr Asn Asn Leu Lys Leu Glu Ala 195 200 205 Ala Gly Arg Ala Leu Lys Tyr Thr Thr Pro Met Lys Pro Cys Tyr Gly 210 215 220 Ser Tyr Ala Arg Pro Thr Asn Glu Asn Gly Gly Gln Gly Thr Leu Gly 225 230 235 240 Asn Asn Gly Lys Thr Thr Pro Ala Glu Leu Gln Phe Phe Asp Leu Ala 245 250 255 Ser Lys Asn Asn Asp Tyr Ser Pro Ala Val Thr Met Tyr Thr Glu Asp 260 265 270 Val Tyr Leu Glu Thr Pro Asp Thr His Ile Ile Tyr Asn Pro Glu Thr 275 280 285 Val Asn Gly Asn Thr Asn Thr Gln Leu Leu Leu Gly Gln Gln Ala Ala 290 295 300 Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Phe 305 310 315 320 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 325 330 335 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 340 345 350 Ser Tyr Gln Leu Met Leu Asp Ala Leu Gly Asp Arg Thr Arg Tyr Phe 355 360 365 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 370 375 380 Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 385 390 395 400 Leu Ser Ala Val Gly Ile Val Asn Asp Tyr Lys Gly Ile Thr Lys Asn 405 410 415 Gly Gly Asn Trp Gln Val Asp Gln Thr Asp Ser Asp Arg Asn Glu Ile 420 425 430 Ala Thr Gly Asn Ile Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu 435 440 445 Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser 450 455 460 Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Glu Asn Lys Asn Thr 465 470 475 480 Tyr Gly Tyr Ile Asn Gly Arg Ile Thr Ala Pro Gly Leu Ile Asp Thr 485 490 495 Tyr Val Asn Ile Gly Ala Arg Trp Ser Pro Asp Pro Met Asp Asn Val 500 505 510 Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met 515 520 525 Leu Leu Gly Asn Gly Arg Val Val Pro Phe His Ile Gln Val Pro Gln 530 535 540 Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly Ser Tyr Thr 545 550 555 560 Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Thr 565 570 575 Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Val Arg Ile Asp Ser 580 585 590 Val Asn Leu Tyr Ala Asn Phe Phe Pro Met Ala His Asn Thr Ala Ser 595 600 605 Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn 610 615 620 Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala 625 630 635 640 Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg 645 650 655 Gly Trp Ser Phe Thr Arg Leu Lys Ala Lys Glu Thr Pro Ser Leu Gly 660 665 670 Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Thr Ile Pro Tyr Leu 675 680 685 Asp Gly Ser Phe Tyr Leu Asn His Thr Phe Lys Arg Leu Ser Ile Met 690 695 700 Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro 705 710 715 720 Asn Glu Phe Glu Ile Lys Arg Val Val Asp Gly Glu Gly Tyr Asn Val 725 730 735 Ala Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Ile Gln Met Leu Ser 740 745 750 His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys 755 760 765 Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln 770 775 780 Ile Val Asp Pro Thr Ser Tyr Thr Ala Tyr Gln Ala Val Ala Leu Pro 785 790 795 800 His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Met Gly Pro Thr Ile 805 810 815 Arg Glu Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly 820 825 830 Ala Thr Ala Val Pro Ala Ile Thr Gln Lys Lys Phe Leu Cys Asp Arg 835 840 845 Val Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala 850 855 860 Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala 865 870 875 880 Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu 885 890 895 Tyr Met Leu Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His 900 905 910 Arg Gly Ile Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly 915 920 925 Asn Ala Thr Thr 930 <210> 72 <211> 903 <212> PRT <213> Equine adenovirus 2 <400> 72 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Ile Val Gln Phe Ala 20 25 30 Gln Ala Arg Lys Pro Tyr Phe His Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Glu Arg Thr Thr Glu Arg Phe Ala Glu Ala 50 55 60 Cys Ser Cys Ala Phe Val Pro Val Asp Lys Glu Asp Thr Val Tyr Thr 65 70 75 80 Tyr Lys Thr Arg Phe Gln Leu Ala Val Gly Asn Asn Arg Val Leu Asp 85 90 95 Met Gly Arg Thr Tyr Phe Tyr Ile Arg Gly Thr Leu Asp Arg Gly Pro 100 105 110 Ser Phe Lys Pro Tyr Ser Gly Thr Gln Tyr Asn Gln Leu Ala Pro Lys 115 120 125 Gly Ala Pro Asn Pro Cys Gln Tyr Gln Lys Asn Asn Thr Thr Val Thr 130 135 140 Phe Gly Gln Ala Ala Phe Glu Gly Val Glu Ile Thr Ala Ser Gly Leu 145 150 155 160 Arg Ile Ala Val Asp Lys Tyr Cys Asp Pro Thr Tyr Gln Pro Glu Pro 165 170 175 Gln Ile Gly Ile Asp Ser Trp Glu Pro Gly Thr Thr Leu Ser Asp Asp 180 185 190 Ile Ala Ala Val Gly Gly Arg Val Leu Asn Asn Gln Gln Asn Pro Thr 195 200 205 Pro Cys Tyr Gly Ser Tyr Ala Pro Pro Thr Asn Val Asp Gly Gly Gln 210 215 220 Gly Asp Gly Asn Pro Thr Leu Lys Phe Phe Lys Thr Gly Thr Gln Ala 225 230 235 240 Ala Arg Pro Asp Ile Val Leu Tyr Ser Glu Asn Val Asn Leu Met Met 245 250 255 Pro Asp Ser His Ile Val Tyr Lys Val Gly Thr Asp Glu Glu Gln Ser 260 265 270 Arg Ala Ala Leu Ala Gln Gln Ala Ala Pro Asn Arg Pro Asn Tyr Val 275 280 285 Ala Phe Arg Asp Asn Phe Ile Gly Leu Leu Tyr Tyr Asn Ser Asn Gly 290 295 300 Asn Leu Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val 305 310 315 320 Asp Leu Gln Asn Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp 325 330 335 Ser Leu Val Asp Arg Asn Arg Tyr Phe Ala Met Trp Asn Gln Ala Val 340 345 350 Asp Ser Tyr Asp Pro Asp Val Arg Ile Val Glu Asn Val Gly Val Glu 355 360 365 Asp Glu Met Pro Asn Tyr Ala Tyr Pro Leu Ser Gly Met Asn Pro Thr 370 375 380 Ala Ala Asn Arg Asn Ser Trp Arg Ser Arg Val Pro Asn Glu Glu Gly 385 390 395 400 Trp Val Ser Lys Gly Asn Leu Asp Ala Leu Glu Leu Asn Ile Pro Ala 405 410 415 Asn Leu Trp Arg Gly Phe Leu Tyr Ser Asn Val Ala Met Tyr Leu Pro 420 425 430 Asp Lys Tyr Lys Phe Thr Pro Pro Asn Thr Thr Leu Pro Glu Asn Glu 435 440 445 Asn Thr Tyr Asp Tyr Met Asn Gly Lys Leu Pro Ala Ala Gly Leu Ile 450 455 460 Asp Ser Tyr Val Asn Val Gly Ser Arg Trp Ser Leu Asp Val Met Asp 465 470 475 480 Asn Ile Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg 485 490 495 Ser Gln Ile Leu Gly Asn Gly Arg Tyr Cys Lys Phe His Ile Gln Val 500 505 510 Pro Gln Lys Phe Phe Ala Ile Arg Asn Leu Leu Leu Leu Pro Gly Thr 515 520 525 Tyr Thr Tyr Glu Trp Ser Phe Arg Lys Asp Val Asn Met Ile Leu Gln 530 535 540 Ser Thr Leu Gly Asn Gly Leu Arg Val Asp Gly Ala Ser Ile Thr Tyr 545 550 555 560 Glu Asn Ile Thr Leu Tyr Ala Ser Phe Phe Pro Met Ala His Asn Thr 565 570 575 Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser 580 585 590 Phe Ile Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Thr Ile Pro Ala 595 600 605 Gly Ala Thr Gln Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala 610 615 620 Phe Arg Gly Trp Ser Phe Thr Arg Ile Lys Ala Lys Glu Thr Pro Ala 625 630 635 640 Leu Gly Ser Pro Phe Glu Pro Tyr Phe Asn Tyr Ser Gly Thr Ile Pro 645 650 655 Tyr Leu Asp Gly Thr Phe Tyr Leu Ser His Thr Phe Arg Arg Val Ser 660 665 670 Val Gln Phe Asp Ser Ser Ala Leu Gly Pro Glu Thr Thr Val Phe Phe 675 680 685 Thr Pro Asn Glu Phe Glu Ile Lys Arg Leu Ile Asp Gly Glu Gly Tyr 690 695 700 Asn Val Ser Gln Ser Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 705 710 715 720 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Tyr His Leu Pro Glu Ser 725 730 735 Tyr Lys Asp Arg Trp Tyr Gly Pro Leu Arg Asn Phe Gln Pro Leu Cys 740 745 750 Arg Gln Val Pro Asp Pro Leu Arg Phe Thr Asp Tyr Lys Ala Val Ser 755 760 765 Val Leu Asn Gln His Asn Asn Ser Gly Phe Thr Gly Tyr Asn Ser Ala 770 775 780 Gly Leu Met Arg Glu Gly Gln Pro Tyr Pro Ala Asn Trp Pro Tyr Pro 785 790 795 800 Leu Ile Gly Lys Asn Ala Val Ala Ser Val Thr Glu Arg Lys Phe Leu 805 810 815 Cys Asp Lys Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser 820 825 830 Met Gly Thr Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ala 835 840 845 Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Glu Glu Pro 850 855 860 Thr Leu Leu Tyr Leu Leu Phe Gln Val Phe Glu Val Ala Arg Val His 865 870 875 880 Gln Pro His Arg Gly Val Ile Glu Val Val Tyr Leu Arg Thr Pro Phe 885 890 895 Ser Ala Gly Asn Ala Thr Thr 900 <210> 73 <211> 952 <212> PRT <213> Human adenovirus 5 <400> 73 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile 130 135 140 Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln 145 150 155 160 Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly 165 170 175 Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr 180 185 190 Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu 195 200 205 Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu 210 215 220 Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro 225 230 235 240 Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly 245 250 255 Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala 260 265 270 Thr Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser 275 280 285 Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro 290 295 300 Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met 305 310 315 320 Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu 325 330 335 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 340 345 350 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 355 360 365 Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe 370 375 380 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 385 390 395 400 Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 405 410 415 Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys 420 425 430 Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp 435 440 445 Lys Asn Glu Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu 450 455 460 Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr 465 470 475 480 Leu Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp 485 490 495 Asn Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly 500 505 510 Leu Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr 515 520 525 Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 530 535 540 Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile 545 550 555 560 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro 565 570 575 Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val 580 585 590 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile 595 600 605 Lys Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His 610 615 620 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp 625 630 635 640 Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile 645 650 655 Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp 660 665 670 Ala Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr 675 680 685 Pro Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser 690 695 700 Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys 705 710 715 720 Val Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 725 730 735 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu 740 745 750 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val 755 760 765 Gln Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro 770 775 780 Glu Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 785 790 795 800 Met Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln 805 810 815 Val Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu 820 825 830 Ala Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr 835 840 845 Pro Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe 850 855 860 Leu Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met 865 870 875 880 Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn 885 890 895 Ser Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu 900 905 910 Pro Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val 915 920 925 His Arg Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro 930 935 940 Phe Ser Ala Gly Asn Ala Thr Thr 945 950 <210> 74 <211> 382 <212> PRT <213> Ovine adenovirus 7 <400> 74 Met Ser Ser Lys Lys Val Thr Lys Ser Ile Lys Lys Arg Lys Ser Thr 1 5 10 15 Thr Glu Glu Phe Gln Asn Lys Val Gln Ala Ala Leu Glu Ile Leu Ala 20 25 30 Lys Phe Gly Glu Cys Val Lys Val Asp Thr Ser Gln Met Lys Phe His 35 40 45 Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ala Gln Tyr Met Lys Lys 50 55 60 Met Lys Ile Ile Asn Leu Thr Tyr Ser Ser Ser Lys Ser Met Ala Thr 65 70 75 80 Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Asp Leu 85 90 95 Ile Pro Asn Phe Asn Ala Ser Gly Cys Tyr Leu Trp Tyr His Asp Trp 100 105 110 Glu Glu Asp Arg Pro Arg Cys Phe His Gly Asp Phe Met Phe Lys Arg 115 120 125 Val Asn Glu Ile Glu Met Pro Pro Thr Ser Glu Ala Gly Val Gln Ala 130 135 140 Leu Lys Glu Gly Arg Gly Val Leu Ser Asn Gly Arg Met Asn Lys Gln 145 150 155 160 Val Val Lys Ile Val Gln Glu His Tyr Val Leu Cys Ala Glu Asp Ala 165 170 175 His Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe 180 185 190 Ser Asp Glu Lys Lys Ala Leu Leu Ala Met Gln Asn Ala Ile Glu Thr 195 200 205 Thr Lys Ala Val Phe Pro Lys Ala Lys Val Gly Asn Met Leu Phe Ile 210 215 220 Leu Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Gln Thr Ile Gly Lys 225 230 235 240 Gln Leu Pro Lys Ile Thr Pro Phe Ser Ile Ser Gly Val Glu Gly Ile 245 250 255 Asp Val Gln Asp Val Asn Arg Val Gln Ala Ala Ala Val Thr Phe Pro 260 265 270 Ala Val Phe Val Phe Gln Cys Cys Asn Tyr Gln Tyr Asn Leu Arg Arg 275 280 285 Asn Asn Gly Lys Phe Cys Glu Met Lys Ile Ser Leu Pro Asp Met Leu 290 295 300 Gln Cys Leu Thr Leu Val Arg Lys Phe Trp Asn Glu Cys Met Gly Asn 305 310 315 320 Asn Ile Pro Ile Gln Phe Ser Gln Phe Lys Trp Asn Gln Ser Phe Gln 325 330 335 Val Lys Asn Thr Met Leu Pro Asn Ile Glu Glu Asp Ser Asp Met Asn 340 345 350 Pro Phe Gly Thr Ile Glu Glu Pro Thr Pro Ser Lys Lys Lys Lys Thr 355 360 365 Ile Leu Glu Ser Ser Ser Glu Glu Glu Asp Glu Asp Glu Asp 370 375 380 <210> 75 <211> 380 <212> PRT <213> Bovine adenovirus 4 <400> 75 Met Ser Thr Lys Lys Gly Ser Lys Leu Ala Arg Lys Gly Arg Ser Glu 1 5 10 15 Asn Glu Glu Thr Gln Gln Lys Ile Gln Ala Ala Leu Glu Ile Val Ser 20 25 30 Lys Phe Gly Glu Tyr Val Lys Val Glu Thr Ser Gln Met Lys Phe His 35 40 45 Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ser Gln Tyr Leu Lys Lys 50 55 60 His Lys Ser Ile Asn Leu Thr Tyr Ser Asn Phe Lys Ser Met Ala Ile 65 70 75 80 Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Gly Leu 85 90 95 Val Pro Asn Phe Asn Val Thr Gly Cys Tyr Leu Trp Tyr His Asp Trp 100 105 110 Asp Glu Arg Pro Arg Cys Phe His Gly Asp Phe Met Leu Lys Lys Val 115 120 125 Asn Glu Ile Glu Met Ser Pro Thr Ser Glu Met Gly Ile Gln Ala Leu 130 135 140 Lys Glu Gly Arg Gly Ile Leu Cys Asn Gly Lys Met Asn Lys Gln Val 145 150 155 160 Val Lys Val Val Gln Glu Asn Phe Met Leu Cys Ser Glu Asp Ala Gln 165 170 175 Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe Ser 180 185 190 Asp Glu Lys Lys Ala Leu Ile Ala Met Gln Asn Ala Phe Gln Thr Thr 195 200 205 Lys Ala Val Phe Pro Asn Ala Lys Ile Gly Asn Met Leu Phe Ile Leu 210 215 220 Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Leu Val Ile Gly Lys Gln 225 230 235 240 Leu Pro Lys Ile Thr Ala Tyr Thr Ile Thr Gly Val Glu Gly Ile Asp 245 250 255 Ala Gln Asp Val Ser Lys Val Gln Ala Ala Ala Val Met Tyr Pro Ala 260 265 270 Val Phe Val Phe Gln Cys Cys Asn Phe Gln Phe Thr Ser Lys Arg Asn 275 280 285 Thr Thr Lys Phe Cys Glu Met Lys Ile Ser Val Pro Asp Met Leu Gln 290 295 300 Cys Leu Thr Leu Val Arg Lys Phe Trp Phe Glu Cys Met Gly Thr Pro 305 310 315 320 Leu Pro Ile Asn Phe Pro Gln Phe Lys Trp Asn Gln Cys Phe Gln Val 325 330 335 Lys Asn Thr Val Leu Pro Ser Ile Glu Glu Asp Val Glu Ala Asn Pro 340 345 350 Phe Gly Glu Val Glu Glu Ala Pro Pro Lys Lys Lys Lys Arg Thr Val 355 360 365 Leu Glu Ser Ser Ser Glu Glu Asp Asp Glu Asp Asp 370 375 380 <210> 76 <211> 380 <212> PRT <213> Bovine adenovirus D <400> 76 Met Ser Thr Lys Lys Gly Ser Lys Leu Ala Arg Lys Gly Arg Ser Glu 1 5 10 15 Asn Glu Glu Thr Gln Gln Lys Ile Gln Ala Ala Leu Glu Ile Val Ser 20 25 30 Lys Phe Gly Glu Tyr Val Lys Val Glu Thr Ser Gln Met Lys Phe His 35 40 45 Pro Glu Glu Gly Asp Cys Glu Lys Leu Phe Ser Gln Tyr Leu Lys Lys 50 55 60 His Lys Ser Ile Asn Leu Thr Tyr Ser Asn Phe Lys Ser Met Ala Ile 65 70 75 80 Val Gly Gly Arg Met Leu Tyr Ser Ala Ile Cys Lys Gln Ile Gly Leu 85 90 95 Val Pro Asn Phe Asn Val Thr Gly Cys Tyr Leu Trp Tyr His Asp Trp 100 105 110 Asp Glu Arg Pro Arg Cys Phe His Gly Asp Phe Met Leu Lys Lys Val 115 120 125 Asn Glu Ile Glu Met Ser Pro Thr Ser Glu Met Gly Ile Gln Ala Leu 130 135 140 Lys Glu Gly Arg Gly Ile Leu Cys Asn Gly Lys Met Asn Lys Gln Val 145 150 155 160 Val Lys Val Val Gln Glu Asn Phe Met Leu Cys Ser Glu Asp Ala Gln 165 170 175 Gln Arg Phe Gly Gln Cys Ser Pro Arg Ser Cys Gly Leu Asn Phe Ser 180 185 190 Asp Glu Lys Lys Ala Leu Ile Ala Met Gln Asn Ala Phe Gln Thr Thr 195 200 205 Lys Ala Val Phe Pro Asn Ala Lys Ile Gly Asn Met Leu Phe Ile Leu 210 215 220 Gly Gln Cys Glu Cys Asn Tyr Gly Gly Lys Leu Val Ile Gly Lys Gln 225 230 235 240 Leu Pro Lys Ile Thr Ala Tyr Thr Ile Thr Gly Val Glu Gly Ile Asp 245 250 255 Ala Gln Asp Val Ser Lys Val Gln Ala Ala Ala Val Met Tyr Pro Ala 260 265 270 Val Phe Val Phe Gln Cys Cys Asn Phe Gln Phe Thr Ser Lys Arg Asn 275 280 285 Thr Thr Lys Phe Cys Glu Met Lys Ile Ser Val Pro Asp Met Leu Gln 290 295 300 Cys Leu Thr Leu Val Arg Lys Phe Trp Phe Glu Cys Met Gly Thr Pro 305 310 315 320 Leu Pro Ile Asn Phe Pro Gln Phe Lys Trp Asn Gln Cys Phe Gln Val 325 330 335 Lys Asn Thr Val Leu Pro Ser Ile Glu Glu Asp Val Glu Ala Asn Pro 340 345 350 Phe Gly Glu Val Glu Glu Ala Pro Pro Lys Lys Lys Lys Arg Thr Val 355 360 365 Leu Glu Ser Ser Ser Glu Glu Asp Asp Glu Asp Asp 370 375 380 <210> 77 <211> 387 <212> PRT <213> Duck adenovirus A <400> 77 Met Ser Ser Lys Lys Ser Thr Ala Thr Ser Ser Lys Lys Ala Lys Arg 1 5 10 15 Ser Ala Gly Leu Thr Asp Thr Glu Leu Glu Arg Gln Gln Asn Glu Ser 20 25 30 Leu Phe Gln Ala Ala Leu Glu Val Val Tyr Lys Leu Gly Glu His Leu 35 40 45 Lys Val Glu Thr Lys Asp Val Thr Phe His Pro Phe Asp Thr Gly Leu 50 55 60 Glu Lys Leu Phe Ala Gln Thr Leu Lys Lys Ala Lys Tyr Thr Pro Ile 65 70 75 80 Tyr Ser Ala Ala Lys Ser Met Asn Val Val Gly Gly Arg Leu Leu Tyr 85 90 95 Gly Ala Ile Cys Asn Tyr Val Gly Leu Ala Pro Asn Phe Asn Pro Thr 100 105 110 Gly Cys Ser Leu Trp Glu His Gly Trp Glu Glu Gly Val Arg Cys Tyr 115 120 125 His Ser Glu Lys Met Ile Leu Lys Glu Asn Ile Ile Glu Met Thr Pro 130 135 140 Thr Ser Glu Ala Ala Ile Ser Ala Leu Lys Glu Gly Arg Gly Leu Leu 145 150 155 160 Ser Ser Asn Lys Tyr Gly Lys Gln Val Val Arg Ile Val Gln Glu Asn 165 170 175 Ser Met Ile Cys Pro Glu Asp Leu Arg Gln Thr Arg Phe Gly Thr Phe 180 185 190 Ser Asn Ser Ser Cys Gly Leu Asn Phe Thr Asp Gly Glu Lys Ala Lys 195 200 205 Leu Ala Tyr Lys Asn Ala Thr Ala Tyr Ile Gln Ala Val Phe Pro Lys 210 215 220 Thr Ala Met Gln His Leu Leu Phe Ile Val Thr Ala Cys Glu Cys Asn 225 230 235 240 Tyr Gly Gly Gln Leu Ile Leu Gly Lys Gln Ile Pro Lys Met Thr Pro 245 250 255 Tyr Thr Val Ser Gly Val Glu Asn Ile Ser Val Lys Asp Leu Asp Pro 260 265 270 Val Lys Ala Val Gly Val Lys Tyr Pro Ala Val Phe Val Phe Gln Cys 275 280 285 Cys Asn Phe Gln Gly Gln Lys Arg Ala Gly Asn Ala Lys Ser Cys Glu 290 295 300 Phe Lys Ile Ser Leu Pro Asp Leu Ile His Cys Leu Ile Thr Ala Arg 305 310 315 320 Asn Leu Trp Phe Glu Val Met Gly Glu Pro Met Pro Val Gln Phe Pro 325 330 335 Leu Phe Lys Trp Ser Pro Ala Leu Gln Val Lys Asn Thr Leu Leu Pro 340 345 350 Ser Cys Asp Val Cys Thr Glu Asp Asn Pro Phe Gly Glu Ile Pro Thr 355 360 365 Lys Arg Lys Arg Val Val Glu Ile Glu Ser Asp Glu Asp Glu Glu Glu 370 375 380 Asp Glu Asp 385 <210> 78 <211> 397 <212> PRT <213> Snake adenovirus <400> 78 Met Ser Leu Ser Lys Thr Lys Asn Pro Ala Leu Leu Ala Gly Pro Gly 1 5 10 15 Asp Glu Ala Lys Glu Lys Val Gln Ala Ala Leu Glu Leu Leu His Lys 20 25 30 Phe Gly Ser Ala Phe Lys Val Asp Thr Ala Gly Phe Ser Phe His Pro 35 40 45 Glu Ser Pro Glu Cys Asp Lys Ile Phe Gly Ala Tyr Leu Lys Asn Val 50 55 60 Lys His Val Pro Thr Tyr Ser Ser Ala Lys Thr Leu Thr Ser Val Gly 65 70 75 80 Gly Arg Ile Leu Tyr Ala Ala Thr Cys Gln Tyr Val Lys Leu Thr Pro 85 90 95 Val Thr Asn Leu Thr Gly Cys Thr Leu Trp Glu His Gly Trp Gly Gln 100 105 110 Asn Leu Lys Cys Tyr His Gly Glu Gly Met Cys Arg Lys Lys Asn Glu 115 120 125 Ile Glu Met Ala Ala Thr Ser Glu Ser Gly Val Ala Ala Leu Lys Glu 130 135 140 Gly Arg Gly Ala Val Glu Ile Asn Arg Trp Gly Arg Gln Val Val Lys 145 150 155 160 Ile Thr Gln Glu Asn Tyr Val Ile Cys Met Glu Asp Leu Gln Ser Arg 165 170 175 Phe Asn Gln Pro Ser Ala Asn Ser Cys Gly Leu Ser Phe Ser Asp Ser 180 185 190 Asp Lys Ala Arg Ser Ala Met Glu Asn Ala Thr Glu Leu Thr Arg Ser 195 200 205 Ile Phe Ser Gln Ala Lys Met Asp His Leu Leu Phe Met Pro Ile Cys 210 215 220 Cys Tyr Cys Asn Tyr Gly Gly Lys Met Ile Leu Gly Arg Gln Leu Cys 225 230 235 240 Lys Leu Thr Pro Phe Ser Ile Ser Gly Thr Glu Gly Leu Arg Glu Glu 245 250 255 Asp Val Ser Pro Val Gln Ala Val Ser Val Arg His Pro Ala Val Phe 260 265 270 Val Phe Gln Cys Cys Asn Ala Thr Gly Gly Ser Lys Gly Lys Thr Ser 275 280 285 Cys Asp Phe Lys Ile Ser His Ala Asp Leu Leu Gln Val Leu Asn Leu 290 295 300 Val Arg Lys Met Trp Leu Glu Val Met Gly Tyr Pro Met Pro Ile His 305 310 315 320 Phe Pro Arg Phe Lys Trp Ser Pro Ser Leu Arg Val Lys Asn Ala Leu 325 330 335 Leu Pro Glu Gly Ser Val Asn Glu Asp Glu Asn Pro Phe Gly Leu Asp 340 345 350 Asn Ser Glu Asp Glu Glu Glu Val Val Pro Pro Ser Pro Pro Ser Pro 355 360 365 Ala Arg Lys Arg Thr Arg Thr Thr Val Ala Glu Val His His Lys Lys 370 375 380 Lys Lys Lys Ile Val Leu Glu Ser Ser Glu Glu Asp Glu 385 390 395 <210> 79 <211> 441 <212> PRT <213> Fowl adenovirus 1 <400> 79 Met Glu Arg Thr Pro Lys Arg Ala His Gly Phe Arg Ser Thr Lys Pro 1 5 10 15 Val Lys Arg Thr Ala Glu Val Met Met Glu Glu Glu Glu Glu Glu Val 20 25 30 Glu Val Val Ala Pro Gly Arg Gly Ala Thr Arg Lys Lys Val Ser Arg 35 40 45 Arg Glu Glu Ser Pro Ser Pro Val Arg Arg Val Thr Arg Arg Arg Glu 50 55 60 Thr Val Val Asp Asp Glu Glu Asn Ala Ser Asp Glu Glu Ser Pro Glu 65 70 75 80 Ala Pro Leu Ser Asp Pro Val Val Tyr Gly Ala Gln Arg Ala Met Ala 85 90 95 Thr Val Ala Ser Ile Cys Glu Ala Leu Asp Leu Gln Trp Gln Gly Ala 100 105 110 Ser Val Arg Pro Asp Asp Ser Ile Trp Thr Lys Met Gly Gly Thr Tyr 115 120 125 Val Arg Lys Lys His Pro Glu Phe Arg Leu Thr Phe Ser Ser Tyr Asp 130 135 140 Ser Phe Asn Ala Gln Val Gly Arg Phe Leu Ala Ala Val Ile Tyr Ser 145 150 155 160 Arg Ala Gly Leu Glu Pro Lys Phe Val Pro Gly Gly Ala His Val Trp 165 170 175 Arg His Gly Trp Phe Pro Ala Leu Gln Glu Pro Phe Pro Lys Cys Met 180 185 190 His Gly Val Asp Met Val Thr Lys Pro Arg Thr Val Glu Leu Asn Pro 195 200 205 Ser Ser Glu Ala Gly Lys Arg Ala Leu Ala Glu Gln Asn Gly Val Ile 210 215 220 Glu Lys Asn Arg Phe Gly Arg Gln Val Val Val Leu Arg Phe Asp Ala 225 230 235 240 Asn Ala Val Cys Tyr Lys Asp Gln Glu His Ser Gly Phe Pro His Pro 245 250 255 His Ala His Gly Ser Cys Ala Met Val Phe Ser Asp Ala Ala Lys Ala 260 265 270 Val Ser Ala Met Arg His Asp Ile Asp Trp Thr Lys Ala Leu Tyr Pro 275 280 285 Asn Ala Asp Lys Arg Arg Ala Glu Glu Cys Val Leu Ile Ser Thr Asn 290 295 300 Cys Asn Cys Asn Tyr Ala Ser Asp Arg Ala Ile Ser Gly Arg Gln Phe 305 310 315 320 Cys Lys Met Thr Pro Tyr Lys Leu Asn Gly Thr Asp Asp Ile Thr Arg 325 330 335 Asp Met Val Glu Ser Arg Pro Asp Met Lys Ala His Lys Lys Asn Pro 340 345 350 His Thr Met Val Phe Thr Cys Cys Asn Pro Gln Ala Ala Ser Gly Gly 355 360 365 Ala Gly Arg Gly Leu Lys Lys Thr Glu Lys Thr Cys Ala Trp Arg Leu 370 375 380 Ser Ala Met Asp Leu Arg Tyr Ala Tyr Val Phe Ala Thr Glu Leu Phe 385 390 395 400 Thr Ala Val Met Gly Ser Ser Glu Pro Thr His Val Pro Glu Phe Arg 405 410 415 Trp Asn Glu Ser Tyr Ala Phe Lys Thr Glu Val Leu Ala Pro Val Ser 420 425 430 Pro Ile Ala Ser Asp Asp Pro Phe Ala 435 440 <210> 80 <211> 549 <212> PRT <213> Fowl adenovirus A <400> 80 Met Ala Glu Thr Leu His Pro Glu Thr Ile Ser Ser Asp Glu Asp Val 1 5 10 15 Ala Asp Phe Val Asp Leu Glu Glu Pro Gly Pro Ser Thr Val Ile Lys 20 25 30 Ser Asn Arg Gly Arg Ser Arg Pro Leu Pro Pro Gln Arg Pro Thr Gly 35 40 45 Pro Lys Asp Pro Glu Asn Pro Leu Glu Lys Gln Lys Ser Glu Asp Leu 50 55 60 Pro Arg Ser His Pro Gly Pro Arg Lys Leu Gln Lys Thr Leu Pro Pro 65 70 75 80 Ser Pro Ala Val Val Pro Asp Ser Glu Glu Glu Gly Glu Gln Glu Leu 85 90 95 Phe Glu Thr Arg Asp Pro Val Thr Glu Ala Glu Val Met Glu Arg Thr 100 105 110 Pro Lys Arg Ala His Gly Phe Arg Ser Thr Lys Pro Val Lys Arg Thr 115 120 125 Ala Glu Val Met Met Glu Glu Glu Glu Glu Glu Val Glu Val Val Ala 130 135 140 Pro Gly Arg Gly Ala Thr Arg Lys Lys Val Ser Arg Arg Glu Glu Ser 145 150 155 160 Pro Ser Pro Val Arg Arg Val Thr Arg Arg Arg Glu Thr Val Val Asp 165 170 175 Asp Glu Glu Asn Ala Ser Asp Glu Glu Ser Pro Glu Ala Pro Leu Ser 180 185 190 Asp Pro Val Val Tyr Gly Ala Gln Arg Ala Met Ala Thr Val Ala Ser 195 200 205 Ile Cys Glu Ala Leu Asp Leu Gln Trp Gln Gly Ala Ser Val Arg Pro 210 215 220 Asp Asp Ser Ile Trp Thr Lys Met Gly Gly Thr Tyr Val Arg Lys Lys 225 230 235 240 His Pro Glu Phe Arg Leu Thr Phe Ser Ser Tyr Asp Ser Phe Asn Ala 245 250 255 Gln Val Gly Arg Phe Leu Ala Ala Val Ile Tyr Ser Arg Ala Gly Leu 260 265 270 Glu Pro Lys Phe Val Pro Gly Gly Ala His Val Trp Arg His Gly Trp 275 280 285 Phe Pro Ala Leu Gln Glu Pro Phe Pro Lys Cys Met His Gly Val Asp 290 295 300 Met Val Thr Lys Pro Arg Thr Val Glu Leu Asn Pro Ser Ser Glu Ala 305 310 315 320 Gly Lys Arg Ala Leu Ala Glu Gln Asn Gly Val Ile Glu Lys Asn Arg 325 330 335 Phe Gly Arg Gln Val Val Val Leu Arg Phe Asp Ala Asn Ala Val Cys 340 345 350 Tyr Lys Asp Gln Glu His Ser Gly Phe Pro His Pro His Ala His Gly 355 360 365 Ser Cys Ala Met Val Phe Ser Asp Ala Ala Lys Ala Val Ser Ala Met 370 375 380 Arg His Asp Ile Asp Trp Thr Lys Ala Leu Tyr Pro Asn Ala Asp Lys 385 390 395 400 Arg Arg Ala Glu Glu Cys Val Leu Ile Ser Thr Asn Cys Asn Cys Asn 405 410 415 Tyr Ala Ser Asp Arg Ala Ile Ser Gly Arg Gln Phe Cys Lys Met Thr 420 425 430 Pro Tyr Lys Leu Asn Gly Thr Asp Asp Ile Thr Arg Asp Met Val Glu 435 440 445 Ser Arg Pro Asp Met Lys Ala His Lys Lys Asn Pro His Thr Met Val 450 455 460 Phe Thr Cys Cys Asn Pro Gln Ala Ala Ser Gly Gly Ala Gly Arg Gly 465 470 475 480 Leu Lys Lys Thr Glu Lys Thr Cys Ala Trp Arg Leu Ser Ala Met Asp 485 490 495 Leu Arg Tyr Ala Tyr Val Phe Ala Thr Glu Leu Phe Thr Ala Val Met 500 505 510 Gly Ser Ser Glu Pro Thr His Val Pro Glu Phe Arg Trp Asn Glu Ser 515 520 525 Tyr Ala Phe Lys Thr Glu Val Leu Ala Pro Val Ser Pro Ile Ala Ser 530 535 540 Asp Asp Pro Phe Ala 545 <210> 81 <211> 437 <212> PRT <213> Fowl adenovirus 9 <400> 81 Met Val Lys Asp Ser Ala Pro Lys Thr Thr Ser Lys Lys Met Ala Ser 1 5 10 15 Ser Asp Asp His Glu Asn Ala Glu Pro Ala Met Val Asp Ser Lys Lys 20 25 30 Lys Arg Ser Ala Lys Ser Arg Gly Ala Ala Pro Ser Lys Lys Ala Arg 35 40 45 Lys Glu Thr Gln Glu Arg Glu Glu Val Asp Glu Lys Lys Ser Glu Leu 50 55 60 Asp Val Glu Ser Asp Glu Glu Leu Glu Arg Pro Leu Ser Asp Pro Val 65 70 75 80 Glu Tyr Gly Ala Gln Lys Ala Met Lys Ile Leu Thr Thr Ile Cys Asp 85 90 95 Arg Leu Asp Val Arg Trp Gln Gly Ser Thr Ile Arg Pro Asp Asp Ala 100 105 110 Ile Trp Thr Arg Ile Gly Gly Thr Phe Val Arg Lys Arg His Pro Glu 115 120 125 Phe Arg Leu Thr Phe Ser Ser Phe Asp Ser Phe His Asn Gln Val Gly 130 135 140 Arg Phe Leu Ala Ala Met Val Tyr Gly Met Ala Glu Leu Glu Pro Lys 145 150 155 160 Phe Val Pro Glu Gly Ala His Val Trp Arg His Gly Trp Glu Ala Thr 165 170 175 Thr Asn Thr Thr Pro Lys Cys Leu His Gly Asn Ala Met Phe Leu Lys 180 185 190 Pro Arg Thr Val Glu Leu Asn Pro Thr Ser Glu Ala Gly Lys Arg Ala 195 200 205 Ile Ala Glu Gln Asn Gly Gln Ile Glu Lys Asn Arg Phe Gly Lys Gln 210 215 220 Val Val Val Leu Arg Phe Asp Arg Asn Ala Val Cys Ser Arg Asp Ala 225 230 235 240 Asp His Ser Gly Phe Pro Tyr Pro His Val Ile Gly Ser Cys Gly Met 245 250 255 Ala Phe Ser Asp Ala Ala Lys Ala Val Ser Ala Met Arg His Asp Leu 260 265 270 Glu Trp Thr Lys Ala Leu Tyr Pro Asn Ala Glu Lys Arg Arg Ala Glu 275 280 285 Glu His Ile Leu Ile Ser Thr Asn Cys Asn Cys Asn Tyr Ala Val Gln 290 295 300 Gly Pro Ile Ser Gly Arg Gln Val Cys Arg Met Ile Pro Tyr Lys Leu 305 310 315 320 Ser Gly Thr Asp Asp Ile Ala Ser Asp Thr Ala Arg Ser Arg Pro Asp 325 330 335 Met Lys Ala His Lys Lys Tyr Pro His Thr Met Val Tyr Thr Cys Cys 340 345 350 Asn Pro Gln Ser Pro Ser Gly Thr Asp Gly Pro Thr Ser Arg Ser Gly 355 360 365 Arg Lys Thr Ser Asp Lys Thr Cys Ala Trp Arg Leu Ser Ala Met Asp 370 375 380 Leu Arg His Ala Tyr Val Phe Ala Thr Glu Leu Val Leu Asn Ala Met 385 390 395 400 Gly Val Gln Ala Pro Thr His Val Pro Glu Phe Arg Trp His Glu Arg 405 410 415 Phe Gly Phe Lys Thr Glu Val Ile Ala Pro Val Lys Pro Val Glu Thr 420 425 430 Gly Asp Pro Phe Ala 435 <210> 82 <211> 556 <212> PRT <213> Fowl adenovirus D <400> 82 Met Ala Glu Ala Ala Asp Arg Asp Leu Trp Val Val Ser Ser Asp Glu 1 5 10 15 Asp Asp Glu Glu Ile Arg Gln Val Phe Gly Ala Arg Glu Lys Thr Pro 20 25 30 Met Pro Asn Ser Asp Asp Ser Glu Ser Asp Trp Ser Gln Pro Lys Thr 35 40 45 Arg Pro Leu Gln Glu Ala Pro Leu Pro Lys Glu Thr Leu Pro Pro Ser 50 55 60 Asp Arg Arg Gly Thr Gly Ser Cys Ser Leu Pro Arg Trp His Lys Ser 65 70 75 80 His Pro Val Lys Val Gln Lys Arg Arg Leu Glu Val Glu Glu Val Phe 85 90 95 Ser Ser Ser Glu Glu Ser Ser Pro Gly Glu Asp Glu Glu Glu Glu Glu 100 105 110 Gly Glu Thr Asp Arg Ser Gly Met Val Lys Asp Ser Ala Pro Lys Thr 115 120 125 Thr Ser Lys Lys Met Ala Ser Ser Asp Asp His Glu Asn Ala Glu Pro 130 135 140 Ala Met Val Asp Ser Lys Lys Lys Arg Ser Ala Lys Ser Arg Gly Ala 145 150 155 160 Ala Pro Ser Lys Lys Ala Arg Lys Glu Thr Gln Glu Arg Glu Glu Val 165 170 175 Asp Glu Lys Lys Ser Glu Leu Asp Val Glu Ser Asp Glu Glu Leu Glu 180 185 190 Arg Pro Leu Ser Asp Pro Val Glu Tyr Gly Ala Gln Lys Ala Met Lys 195 200 205 Ile Leu Thr Thr Ile Cys Asp Arg Leu Asp Val Arg Trp Gln Gly Ser 210 215 220 Thr Ile Arg Pro Asp Asp Ala Ile Trp Thr Arg Ile Gly Gly Thr Phe 225 230 235 240 Val Arg Lys Arg His Pro Glu Phe Arg Leu Thr Phe Ser Ser Phe Asp 245 250 255 Ser Phe His Asn Gln Val Gly Arg Phe Leu Ala Ala Met Val Tyr Gly 260 265 270 Met Ala Glu Leu Glu Pro Lys Phe Val Pro Glu Gly Ala His Val Trp 275 280 285 Arg His Gly Trp Glu Ala Thr Thr Asn Thr Thr Pro Lys Cys Leu His 290 295 300 Gly Asn Ala Met Phe Leu Lys Pro Arg Thr Val Glu Leu Asn Pro Thr 305 310 315 320 Ser Glu Ala Gly Lys Arg Ala Ile Ala Glu Gln Asn Gly Gln Ile Glu 325 330 335 Lys Asn Arg Phe Gly Lys Gln Val Val Val Leu Arg Phe Asp Arg Asn 340 345 350 Ala Val Cys Ser Arg Asp Ala Asp His Ser Gly Phe Pro Tyr Pro His 355 360 365 Val Ile Gly Ser Cys Gly Met Ala Phe Ser Asp Ala Ala Lys Ala Val 370 375 380 Ser Ala Met Arg His Asp Leu Glu Trp Thr Lys Ala Leu Tyr Pro Asn 385 390 395 400 Ala Glu Lys Arg Arg Ala Glu Glu His Ile Leu Ile Ser Thr Asn Cys 405 410 415 Asn Cys Asn Tyr Ala Val Gln Gly Pro Ile Ser Gly Arg Gln Val Cys 420 425 430 Arg Met Ile Pro Tyr Lys Leu Ser Gly Thr Asp Asp Ile Ala Ser Asp 435 440 445 Thr Ala Arg Ser Arg Pro Asp Met Lys Ala His Lys Lys Tyr Pro His 450 455 460 Thr Met Val Tyr Thr Cys Cys Asn Pro Gln Ser Pro Ser Gly Thr Asp 465 470 475 480 Gly Pro Thr Ser Arg Ser Gly Arg Lys Thr Ser Asp Lys Thr Cys Ala 485 490 495 Trp Arg Leu Ser Ala Met Asp Leu Arg His Ala Tyr Val Phe Ala Thr 500 505 510 Glu Leu Val Leu Asn Ala Met Gly Val Gln Ala Pro Thr His Val Pro 515 520 525 Glu Phe Arg Trp His Glu Arg Phe Gly Phe Lys Thr Glu Val Ile Ala 530 535 540 Pro Val Lys Pro Val Glu Thr Gly Asp Pro Phe Ala 545 550 555 <210> 83 <211> 346 <212> PRT <213> Turkey adenovirus 3 <400> 83 Met Gln Tyr Ala Thr Gly Leu Gln Ala Leu Phe Ala Cys Gln Ala Glu 1 5 10 15 Ala Asn Ile Leu Pro Thr Ser Asp Tyr Trp Ala Lys Leu Val Glu Thr 20 25 30 Tyr Val Lys Lys Asn Lys Pro Asp Leu Asn Leu Thr Ile Ser Ser Ala 35 40 45 Lys Ser Phe Tyr His Phe Ala Gly Arg Ile Val Ser Ser Phe Val Tyr 50 55 60 Asn Asp Ser Gly Leu Ile Cys Asn Tyr Asn Cys Leu Gly Ala Asn Ile 65 70 75 80 Trp Val His Asn Trp Asp Glu Asp Asn Ile Arg Cys Phe His Gly Thr 85 90 95 Val Met Leu Ser Lys Pro Ile Thr Tyr Ser Leu Ser Pro Gln Ser Glu 100 105 110 Glu Gly Met Arg Ala Leu Thr Ala Gly Glu Gly Arg Leu Glu Lys Glu 115 120 125 Lys Asn Gln Lys Asp Val Ile Lys Leu Thr Asn Tyr Ser Asn Ile Val 130 135 140 Cys Pro Leu Asp Ser Asn Val Gln Trp Pro Thr Ile His Ser Pro Asp 145 150 155 160 Ser Cys Gly Met Asn Phe Gly Asn Lys Glu Lys Ala Lys Ala Ala Phe 165 170 175 Leu His Asn Ile Asp Trp Thr Ser Ala Met Phe Pro Lys Ala Lys Lys 180 185 190 Cys Glu Ile Ser Glu Lys Met Ile Ile Val Thr Lys Cys Phe Cys Asn 195 200 205 Tyr Gly His Glu Asn Ile Gln Leu Gly Arg Gln Ile Cys Lys Met Thr 210 215 220 Ala Phe Glu Ile Pro Gly Ala Asn Asp Ile Asp Pro Glu Ser Cys His 225 230 235 240 Asp Asp Met Leu Leu Ala Thr Ala Lys Tyr Lys His Thr Phe Val Phe 245 250 255 Gln Cys Cys Asn Pro Ile Arg Leu Lys Arg Asn Ala Lys Asp Lys Asp 260 265 270 Asn Gln Thr His Lys His Cys Asp Phe Lys Leu Ser Met Ile Asp Val 275 280 285 Arg Gln Ala Met Lys Ile Ser Lys Asp Ile Tyr Thr Lys Leu Lys Glu 290 295 300 Thr Ile Asp Asp Gly Ser Pro Thr Lys Ile Met Leu Pro Ala Phe Val 305 310 315 320 Phe Asn Pro Lys Lys His Ser Phe Lys Gln Ala Ile Val Ala Gln His 325 330 335 Glu Val Glu Ser Asp Asp Asp Ala Phe Cys 340 345 <210> 84 <211> 380 <212> PRT <213> Turkey adenovirus A <400> 84 Met Ser Ser Asp Gln Arg Ser Leu Val Asp Ser Glu Glu Glu Pro Cys 1 5 10 15 Leu Lys Arg Gln Arg Val Glu Asn Asp Glu Phe Glu Asn Cys His Gln 20 25 30 Lys Ala Met Gln Tyr Ala Thr Gly Leu Gln Ala Leu Phe Ala Cys Gln 35 40 45 Ala Glu Ala Asn Ile Leu Pro Thr Ser Asp Tyr Trp Ala Lys Leu Val 50 55 60 Glu Thr Tyr Val Lys Lys Asn Lys Pro Asp Leu Asn Leu Thr Ile Ser 65 70 75 80 Ser Ala Lys Ser Phe Tyr His Phe Ala Gly Arg Ile Val Ser Ser Phe 85 90 95 Val Tyr Asn Asp Ser Gly Leu Ile Cys Asn Tyr Asn Cys Leu Gly Ala 100 105 110 Asn Ile Trp Val His Asn Trp Asp Glu Asp Asn Ile Arg Cys Phe His 115 120 125 Gly Thr Val Met Leu Ser Lys Pro Ile Thr Tyr Ser Leu Ser Pro Gln 130 135 140 Ser Glu Glu Gly Met Arg Ala Leu Thr Ala Gly Glu Gly Arg Leu Glu 145 150 155 160 Lys Glu Lys Asn Gln Lys Asp Val Ile Lys Leu Thr Asn Tyr Ser Asn 165 170 175 Ile Val Cys Pro Leu Asp Ser Asn Val Gln Trp Pro Thr Ile His Ser 180 185 190 Pro Asp Ser Cys Gly Met Asn Phe Gly Asn Lys Glu Lys Ala Lys Ala 195 200 205 Ala Phe Leu His Asn Ile Asp Trp Thr Ser Ala Met Phe Pro Lys Ala 210 215 220 Lys Lys Cys Glu Ile Ser Glu Lys Met Ile Ile Val Thr Lys Cys Phe 225 230 235 240 Cys Asn Tyr Gly His Glu Asn Ile Gln Leu Gly Arg Gln Ile Cys Lys 245 250 255 Met Thr Ala Phe Glu Ile Pro Gly Ala Asn Asp Ile Asp Pro Glu Ser 260 265 270 Cys His Asp Asp Met Leu Leu Ala Thr Ala Lys Tyr Lys His Thr Phe 275 280 285 Val Phe Gln Cys Cys Asn Pro Ile Arg Leu Lys Arg Asn Ala Lys Asp 290 295 300 Lys Asp Asn Gln Thr His Lys His Cys Asp Phe Lys Leu Ser Met Ile 305 310 315 320 Asp Val Arg Gln Ala Met Lys Ile Ser Lys Asp Ile Tyr Thr Lys Leu 325 330 335 Lys Glu Thr Ile Asp Asp Gly Ser Pro Thr Lys Ile Met Leu Pro Ala 340 345 350 Phe Val Phe Asn Pro Lys Lys His Ser Phe Lys Gln Ala Ile Val Ala 355 360 365 Gln His Glu Val Glu Ser Asp Asp Asp Ala Phe Cys 370 375 380 <210> 85 <211> 378 <212> PRT <213> Frog adenovirus 1 <400> 85 Met Ser Glu Lys Arg Pro Ala Val Asp His Glu Glu Glu Pro Gln Ala 1 5 10 15 Lys Lys Gln Leu Glu Asp Asn Phe Ile Leu Cys Glu Glu Ala Ala Lys 20 25 30 Asn Tyr Ala Ser Ala Leu Ala Gly Met Ile Gly Cys Pro Thr Asp Val 35 40 45 Asn Leu Leu Pro Thr Ser Glu Phe Trp Ala Arg Ile Ser Glu Asn Tyr 50 55 60 Ile Lys Lys Phe Arg Thr Asp Phe Phe Leu Thr Asn Ser Thr Leu Lys 65 70 75 80 Ser Phe Thr His Tyr Leu Gly Arg Leu Leu Ala Ser Tyr Val His Ala 85 90 95 Thr Ala Gly Phe Glu Pro Lys Phe Asn Ile Leu Gly Ser Glu Ile Trp 100 105 110 Val His Asn Trp Glu Glu Gly Glu Asn Leu Glu Leu Arg Cys Phe His 115 120 125 Gly Glu Lys Met Met Lys Lys Thr Ile Ser Tyr Glu Leu Val Pro Thr 130 135 140 Thr Val Glu Ala Val Lys Ala Leu Ala Ser Gly Glu Gly Lys Leu Glu 145 150 155 160 Lys Gly Lys Gly Asn Lys Asp Val Val Lys Ile Val Asn Asn Lys Asn 165 170 175 Tyr Val Cys Pro Lys Asp Ile Asp Tyr Asn Gly Phe Pro Ala Ile His 180 185 190 Ala Ser Thr Ser Cys Gly Leu Asn Phe Ala Asn Gly Glu Lys Ala Lys 195 200 205 Ser Ala Phe Leu His Tyr Ala Asp Trp Thr Gln Ala Met Tyr Pro Lys 210 215 220 Ala Asn Arg Ala Ser Ile Arg Glu Lys Met Ile Ile Val Thr Arg Cys 225 230 235 240 Leu Cys Asn Phe Gly His Asp Asn Val Gln Val Gly Arg Gln Ile Ser 245 250 255 Lys Leu Thr Pro Phe Glu Ile Pro Gly Ser Asn Asp Leu Thr Gln Asp 260 265 270 Gln Met Asp Glu Cys Gly Met Met Lys Ala Thr Gly Gln His Gln Ala 275 280 285 Thr Ile Val Phe Leu Cys Cys Asn Pro Val Asn Phe Arg Ala Lys Val 290 295 300 Thr Ile Ala Lys Asn Cys Asp Phe Lys Leu Ser Met Ile Asp Leu Arg 305 310 315 320 Leu Ala Ile Lys Met Ser Lys Glu Ile Trp Ala Lys Leu Asn Asp Gln 325 330 335 Leu Glu Gly Lys Leu Ala Pro Ala Lys Leu Ala Phe Pro Val Phe Lys 340 345 350 Phe Asp Pro Lys Arg His Cys Tyr Lys Ser Ala Val Val Cys Ala Gln 355 360 365 Glu Val Glu Glu Asp Glu Asp Val Phe Cys 370 375 <210> 86 <211> 461 <212> PRT <213> Murine adenovirus 3 <400> 86 Met Ser Cys Ser Arg Pro Leu Pro Pro His Arg Val Gly Gln Gln Gln 1 5 10 15 Val Phe Gly Ser Arg Lys Gly Gly Met Lys Arg Leu Pro Pro Thr Glu 20 25 30 Ala Gly Glu Ser Ser Lys Arg Ser Arg Thr Val Ala Glu Ala Val Thr 35 40 45 Ser Thr Gly Gly Ser Gly Ser Thr Gly Gly Ile Gly Asp Arg Pro Leu 50 55 60 Gly Ala Val Cys Asp Ser Pro Thr Asn Pro Glu Pro Gln Glu Glu Val 65 70 75 80 Leu Pro Arg Arg Arg Phe Glu Ser Ser Asp Glu Glu Glu Asp Val Phe 85 90 95 Asp Asp Gly Thr Val Thr Glu Glu Glu Ala Cys Trp Gln Thr Ala Arg 100 105 110 Glu Phe Leu His Lys Met Cys Leu Pro Leu Lys Val Asp Gly Lys Gln 115 120 125 Cys Thr Phe Leu Pro Asn Ala Gln Thr Ala Glu Leu Phe Arg Lys Leu 130 135 140 Cys His Ser Trp Leu Leu Gln Gln Lys Met Val Pro Ser Leu Thr Phe 145 150 155 160 Thr Thr Leu Arg Ser Phe Thr Met Gln Met Gly Arg Phe Val Leu Ala 165 170 175 Leu Leu Leu Gln Ala Ser Gly Leu Ser Pro Thr Glu Ala Ala Ala His 180 185 190 Ser Ile Ala Asn Val Ser Gly Val Ala Ala Trp Lys His Ala Ser Asp 195 200 205 Val Thr Leu His Cys Leu His Gly Ala Val Met Ile Ala Lys Asp His 210 215 220 His Val Asp Leu Asp Val Ser Ser Glu Gly Gly Gln Arg Ala Leu Lys 225 230 235 240 Glu Gln Gly Pro Asn Ala Val Val Thr Thr Asn Arg Trp Gly Arg Ser 245 250 255 Val Val Arg Val Lys Tyr Asp Ala Phe Val Cys Pro Met Asp Ala Gly 260 265 270 Val Pro Phe Asn Gln Pro Ser Asn Lys Ser Cys Gly Phe Cys Phe Thr 275 280 285 Asp Gly Lys Lys Ala Leu Lys Gly Phe Lys Gln Ile Val Ala Phe Gln 290 295 300 Ala Ala Leu Tyr Pro Gln Ala Ala Gly Gly Gly Glu Trp Met Leu Leu 305 310 315 320 Cys Leu Arg Cys Glu Cys Asn Phe Gly Val Ala Gln Pro Ile Leu Gly 325 330 335 Arg Gln Thr Cys Arg Leu Thr Pro Tyr Gln Leu Ser Leu Ala Glu Gly 340 345 350 Leu Asp Gly Gly Asn Met Asp Ala Val Ala Lys Ala Ser Val Glu Asn 355 360 365 Pro Val Val Leu Val Ala Gln Cys Cys Asn Val Thr Phe Ser Lys Ala 370 375 380 Gly Lys Ala Gly Gly Ala Ala Ala Gly Lys Thr Cys Glu Trp Lys Ile 385 390 395 400 Ser Ser Val Asp Leu Val Thr Ala Ala Gln Leu Ala Lys Lys Met Ile 405 410 415 His Lys Met Leu Asp Leu Pro Pro Ser Leu Phe Val Pro Glu Phe Lys 420 425 430 Trp Asp Pro Val Phe Ser Phe Arg Ser Thr Val Leu Pro Gln Gly Val 435 440 445 Gly Asp Ser Asp Leu Gln Leu Phe Thr Thr Gly Gly Met 450 455 460 <210> 87 <211> 461 <212> PRT <213> Murine adenovirus A <400> 87 Met Ser Cys Ser Arg Pro Val Pro Pro Gln Arg Thr Pro Gln Gln Gln 1 5 10 15 Val Tyr Glu Thr Lys Arg Gly Gly Val Lys Arg Ser Ala Val Gly Glu 20 25 30 Ala Ser Thr Ala His Cys Gly Lys Lys Ser Arg Ala Ala Leu Gly Pro 35 40 45 Arg Ser Ser Pro Leu Ala Pro Ala Val Ser Gly Lys Phe Ala Asn Val 50 55 60 Ser Gly Gly Asp Arg Gly Ser Glu Asp Val Asn Met Glu Pro Glu Pro 65 70 75 80 Gln Thr Glu Val Pro Pro Arg Phe Glu Ser Ser Asp Glu Asp Asp Val 85 90 95 Val Phe Thr Glu Ala Gly Val Ala Glu Glu Glu Glu Ala Cys Trp Gln 100 105 110 Thr Ala Arg Glu Leu Leu His Lys Met Cys Leu Val Leu Lys Val Asp 115 120 125 Gly Lys Gln Cys Thr Phe Leu Pro Asn Ala Gln Thr Ala Glu Leu Phe 130 135 140 Arg Lys Leu Ser His Ser Trp Leu Leu Gln Gln Lys Leu Val Pro Ser 145 150 155 160 Leu Thr Phe Ser Thr Leu Arg Ser Phe Thr Met Gln Met Gly Arg Phe 165 170 175 Val Phe Ala Met Leu Leu Gln Ala Ala Gly Ile Ser Pro Val Asp Phe 180 185 190 Ala Ala His Thr Leu Gly Asn Val Thr Gly Val Ala Ala Trp Lys His 195 200 205 Asn Cys Ser Thr Thr Leu His Cys Leu His Gly Thr Ala Met Ser Pro 210 215 220 Lys Asp His Gln Val Glu Leu Asp Val Thr Thr Glu Gly Gly Gln Arg 225 230 235 240 Ala Leu Lys Glu Gln Gly Ser Ala Ala Cys Val Gln Thr Asn Arg Trp 245 250 255 Gly Arg Ser Val Val Arg Val Thr Tyr Asp Ala Val Val Cys Ala Met 260 265 270 Asp Ala Ser Val Ala Phe Asn Gln Pro Thr Asn Lys Ser Cys Gly Phe 275 280 285 Cys Phe Thr Asp Ala Lys Lys Ala Leu Lys Gly Phe Lys Gln Ala Ile 290 295 300 Ala Phe Gln Gln Ala Leu Tyr Pro Gln Ala Pro Gly Val Gly Glu Arg 305 310 315 320 Met Leu Leu Cys Leu Arg Cys Glu Cys Asn Phe Gly Leu Ala Gln Pro 325 330 335 Ile Leu Gly Arg Gln Thr Cys Arg Val Thr Pro Tyr Ala Leu Ser Leu 340 345 350 Ala Glu Gly Leu Asp Ala Thr Ala Leu Asp Pro Val Ala Arg Ala Ser 355 360 365 Val Glu Asn Pro Val Val Leu Val Tyr Gln Cys Cys Asn Val Thr Phe 370 375 380 Gly Lys Ala Gly Lys Gly Thr Val Gly Lys Ser Cys Glu Trp Lys Ile 385 390 395 400 Ser Ser Val Asp Val Val Thr Ala Ala Gln Leu Ala Lys Lys Met Ile 405 410 415 Gln Lys Leu Leu Asp Gln Pro Pro Ser Leu Phe Val Pro Glu Phe Lys 420 425 430 Trp Asp Pro Thr Leu Cys Phe His Ser Thr Val Leu Pro Gln Gly Ala 435 440 445 Gly Asp Gly Asp Val Gln Leu Phe Val Thr Ala Lys Val 450 455 460 <210> 88 <211> 513 <212> PRT <213> Simian adenovirus 22 <400> 88 Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg 1 5 10 15 Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu 20 25 30 Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg 35 40 45 Val Val Ser Asp Asp Gly Gln Glu Glu Glu Ile Val Val Val Ser Glu 50 55 60 Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Pro Leu Pro Pro Lys 65 70 75 80 Lys Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln 85 90 95 Asp Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly 100 105 110 Phe Ser Phe Pro Pro Val Arg Ile Thr Glu Lys Asp Gly Lys Arg Val 115 120 125 Phe Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr 130 135 140 Lys Met Thr Thr Ala Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser 145 150 155 160 Ala Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr 165 170 175 Arg Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln 180 185 190 Gly Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His 195 200 205 Arg Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Thr Met 210 215 220 Met Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala 225 230 235 240 His Lys Asn Trp Glu Cys Thr Gly Cys Ala Leu Trp Leu His Gly Cys 245 250 255 Thr Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile 260 265 270 Gln Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln 275 280 285 Arg Ala Leu Lys Glu Asn Pro Asp Arg Ala Lys Ile Thr Gln Asn Arg 290 295 300 Trp Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys 305 310 315 320 Val His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys 325 330 335 Gly Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln 340 345 350 Leu Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln 355 360 365 Ala Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro 370 375 380 Gly Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe 385 390 395 400 Gly Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala 405 410 415 Thr Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys 420 425 430 Cys Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn 435 440 445 Cys Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu 450 455 460 Thr Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys 465 470 475 480 Leu Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn 485 490 495 Val Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp 500 505 510 Phe <210> 89 <211> 512 <212> PRT <213> Simian adenovirus 24 <400> 89 Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg 1 5 10 15 Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu 20 25 30 Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg 35 40 45 Val Val Ser Asp Asp Gly Gln Gly Glu Glu Ile Val Val Val Ser Glu 50 55 60 Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Pro Leu Pro Pro Lys 65 70 75 80 Lys Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln 85 90 95 Asp Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly 100 105 110 Phe Ser Phe Pro Pro Val Arg Ile Thr Glu Lys Asp Gly Lys Arg Val 115 120 125 Phe Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr 130 135 140 Lys Met Thr Thr Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser Ala 145 150 155 160 Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr Arg 165 170 175 Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln Gly 180 185 190 Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His Arg 195 200 205 Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Thr Met Met 210 215 220 Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala His 225 230 235 240 Lys Asn Trp Glu Ser Thr Gly Cys Ala Leu Trp Leu His Gly Cys Thr 245 250 255 Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile Gln 260 265 270 Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln Arg 275 280 285 Ala Leu Lys Glu Asn Pro Asp Arg Ala Lys Ile Thr Gln Asn Arg Trp 290 295 300 Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys Val 305 310 315 320 His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys Gly 325 330 335 Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Leu 340 345 350 Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln Ala 355 360 365 Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro Gly 370 375 380 Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe Gly 385 390 395 400 Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala Thr 405 410 415 Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys Cys 420 425 430 Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn Cys 435 440 445 Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu Thr 450 455 460 Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys Leu 465 470 475 480 Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn Val 485 490 495 Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp Phe 500 505 510 <210> 90 <211> 512 <212> PRT <213> Simian adenovirus 23 <400> 90 Met Ala Gly Arg Gly Gly Ser Gln Ser Glu Gln Arg Arg Gln Glu Arg 1 5 10 15 Thr Pro Glu Arg Gly Arg Gly Ser Ala Ser Arg Pro Pro Asn Arg Glu 20 25 30 Ser Pro Ser Pro Pro Pro Leu Pro Gln Lys Arg His Ala Tyr Arg Arg 35 40 45 Val Val Ser Asp Asp Gly Gln Glu Glu Glu Ile Val Val Val Asn Glu 50 55 60 Asn Ser Arg Ser Pro Ser Thr Ser Pro Pro Pro Leu Pro Pro Lys Lys 65 70 75 80 Lys Pro Arg Lys Thr Lys His Val Pro Leu Gln Asp Ile Ser Gln Asp 85 90 95 Ser Glu Asp Glu Arg Gln Ala Glu Glu Glu Leu Ala Ala Val Gly Phe 100 105 110 Ser Phe Pro Pro Val Arg Ile Ile Glu Lys Asp Gly Lys Arg Val Phe 115 120 125 Glu Thr Leu Asp Glu Asn Asp Pro Leu Thr Ser Ala Ala Ala Thr Lys 130 135 140 Met Thr Met Ala Val Lys Asn Pro Leu Ser Leu Pro Ile Val Ser Ala 145 150 155 160 Trp Glu Lys Gly Met Glu Val Met Thr Leu Leu Met Asp Arg Tyr Arg 165 170 175 Val Glu Ser Asp Leu Lys Ser Ala Phe Gln Leu Met Pro Glu Gln Gly 180 185 190 Glu Val Tyr Arg Arg Ile Cys His Leu Tyr Val Asn Glu Glu His Arg 195 200 205 Gly Ile Pro Leu Thr Phe Thr Ser Asn Lys Thr Leu Thr Ala Met Met 210 215 220 Gly Arg Phe Leu Gln Gly Phe Val His Ser His Ser Gln Ile Ala His 225 230 235 240 Lys Asn Trp Glu Cys Thr Gly Cys Ala Leu Trp Leu His Gly Cys Thr 245 250 255 Glu Ala Glu Gly Lys Leu Arg Cys Leu His Gly Thr Val Met Ile Gln 260 265 270 Lys Glu His Thr Ile Glu Met Asp Val Ala Ser Glu Asn Gly Gln Arg 275 280 285 Ala Leu Lys Glu Asn Pro Asn Arg Ala Lys Ile Thr Gln Asn Arg Trp 290 295 300 Gly Arg Ser Val Val Gln Leu Ala Asn Asn Asp Ala Arg Cys Cys Val 305 310 315 320 His Asp Ala Gly Cys Ala Thr Asn Gln Phe Ser Ser Lys Ser Cys Gly 325 330 335 Val Phe Phe Thr Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Leu 340 345 350 Glu Ala Phe Met Lys Ala Met Tyr Pro Gly Met Ser Ser Glu Gln Ala 355 360 365 Gln Met Met Leu Ile Pro Leu His Cys Asp Cys Asn His Lys Pro Gly 370 375 380 Cys Val Pro Ser Met Gly Arg Gln Thr Cys Lys Met Thr Pro Phe Gly 385 390 395 400 Met Ala Asn Ala Glu Asp Leu Asp Val Glu Gly Ile Thr Asp Ala Thr 405 410 415 Val Leu Ala Ser Val Lys His Pro Ala Leu Met Val Phe Gln Cys Cys 420 425 430 Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Asn Ala Gly Pro Asn Cys 435 440 445 Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Gly Ala Leu Gln Leu Thr 450 455 460 Arg Lys Leu Trp Ser Asp Ser Phe Pro Asp Leu Pro Val Pro Lys Leu 465 470 475 480 Leu Ile Pro Glu Phe Lys Trp Leu Pro Lys Tyr Gln Phe Arg Asn Val 485 490 495 Ser Leu Pro Ala Gly His Ala Glu Ser Arg Gln Asn Pro Phe Asp Phe 500 505 510 <210> 91 <211> 462 <212> PRT <213> Simian adenovirus 1 <400> 91 Met Ala Asn Arg Gln Asn Gln Ala Gly Ser Ser Ile Thr Pro Tyr Leu 1 5 10 15 Arg Glu Met Ser Pro Glu Arg Glu Gln Glu Ala Pro Gln Leu Pro Pro 20 25 30 Lys Lys Lys Ala Arg Lys Ala Thr Pro Ala Pro Pro Pro Ser Pro Glu 35 40 45 Ile Val Ser Asp Ser Glu Gly Glu Gly Thr Val Val Glu Val Gly Phe 50 55 60 Ser Tyr Pro Pro Val Arg Arg Val Arg Arg Ala Asp Gly Ser Val Glu 65 70 75 80 Phe Gln Arg Met Thr Met Lys Asp Val Gly Ala Gly Glu Gly Pro Ser 85 90 95 Thr Ala Val Leu Val Lys Asn Pro Asp Ser Lys Pro Leu Val Thr Ala 100 105 110 Trp Glu Lys Gly Met Glu Thr Met Met Met Leu Met Glu Lys Phe His 115 120 125 Val Asp Asn Asp Ser Arg Ala Ala Phe Lys Phe Leu Pro Asp Gln Gly 130 135 140 Ala Val Tyr Arg Lys Ile Cys Gln Thr Trp Leu Asn Glu Glu His Arg 145 150 155 160 Gly Leu Pro Leu Thr Phe Thr Asn Gln Lys Thr Phe Thr Glu Leu Met 165 170 175 Gly Arg Phe Leu Met Ala Tyr Met Glu Ala Tyr Ala Gly Val Lys His 180 185 190 Lys Ser Trp Glu Pro Thr Gly Cys Ala Val Trp Glu His Arg Ser Thr 195 200 205 Gln Gln Glu Gly Val Leu Phe Cys Phe His Gly Val Glu Met Val Cys 210 215 220 Lys Glu His Val Leu Glu Met Asp Val Thr Ser Glu Asn Gly Gln Arg 225 230 235 240 Ala Leu Lys Glu His Pro Thr Arg Ala Lys Val Val Gln Asn Arg Trp 245 250 255 Gly Arg Asn Val Val Gln Leu Lys Asn Glu Asp Ala Arg Cys Cys Ala 260 265 270 Glu Asp Val Asn Cys Gly His Asn Val Phe Ser Ser Lys Ser Cys Gly 275 280 285 Leu Phe Tyr Thr Glu Gly Gly Lys Ala Gln Met Ala Phe Arg Gln Met 290 295 300 Glu Glu Phe Leu Ala Ala Ser Tyr Pro Ile Met Gln Arg Gly Gln Arg 305 310 315 320 Arg Ile Leu Ile Pro Leu Arg Cys Asp Cys Leu Asn Lys Arg Asp Leu 325 330 335 Val Pro Gln Ile Gly Arg Gln Met Cys Lys Leu Thr Pro Phe Ala Leu 340 345 350 Ser Asn Ala Glu Asp Leu Asp Ala Ser Glu Val Thr Asp Pro Thr Ala 355 360 365 Leu Ala Ser Ile His Asn Pro Gly Val Leu Val Phe Gln Cys Ala Asn 370 375 380 Pro Val Phe Arg Asn Ser Arg Gly Ser Ser Gly Pro Asn Cys Asp Phe 385 390 395 400 Lys Ile Ser Ala Pro Asp Val Met Gly Ala Leu Gln Leu Val Arg Gln 405 410 415 Phe Trp Lys Gln Asn Leu Glu Asp Val Pro Leu Pro Arg Leu Val Ile 420 425 430 Pro Glu Phe Arg Trp Ser Ala Arg Phe Gln Tyr Arg Asn Val Ser Leu 435 440 445 Pro Ser Gly His Glu Asp Pro Ser Leu Glu Pro Phe Asp Phe 450 455 460 <210> 92 <211> 462 <212> PRT <213> Simian adenovirus 7 <400> 92 Met Ala Asn Arg Gln Asn Gln Pro Gly Ser Ser Ile Thr Pro Tyr Leu 1 5 10 15 Arg Glu Met Ser Pro Glu Arg Glu Gln Glu Val Pro Pro Leu Pro Pro 20 25 30 Lys Lys Lys Ala Arg Lys Ser Ala Pro Val Pro Pro Pro Ser Pro Glu 35 40 45 Ile Val Ser Asp Ser Glu Gly Glu Ser Thr Val Met Glu Val Gly Phe 50 55 60 Ser Tyr Pro Pro Met Arg Arg Val Arg Arg Ala Asp Gly Thr Val Glu 65 70 75 80 Phe Gln Lys Met Ser Met Lys Asp Val Gly Ala Gly Glu Gly Pro Ser 85 90 95 Thr Ala Val Leu Val Lys Asn Pro Glu Ser Ala Pro Leu Val Thr Ala 100 105 110 Trp Glu Lys Gly Met Glu Val Met Thr Met Leu Met Glu Lys Phe His 115 120 125 Val Asp Asn Glu Ser Arg Thr Thr Phe Lys Phe Leu Pro Asp Gln Gly 130 135 140 Ala Val Tyr Arg Lys Ile Cys Gln Thr Trp Leu Asn Glu Glu His Arg 145 150 155 160 Gly Leu Pro Leu Thr Phe Thr Asn Gln Lys Thr Phe Thr Glu Leu Met 165 170 175 Gly Arg Phe Leu Met Ala Tyr Met Glu Ala Tyr Ala Gly Val Lys His 180 185 190 Lys Ser Trp Glu Ser Thr Gly Cys Ala Val Trp Glu His Arg Asn Thr 195 200 205 Gln Gln Glu Gly Ile Leu Phe Cys Phe His Gly Val Glu Met Val Cys 210 215 220 Lys Glu His Val Val Glu Met Asp Val Thr Ser Glu Asn Gly Gln Arg 225 230 235 240 Ala Leu Lys Glu His Pro Thr Lys Ala Lys Val Val Gln Asn Arg Trp 245 250 255 Gly Arg Asn Val Val Gln Leu Lys Asn Glu Asp Ala Arg Cys Cys Ala 260 265 270 Glu Asp Ile Asn Cys Gly Asn Asn Val Phe Ser Ser Lys Ser Cys Gly 275 280 285 Leu Phe Phe Thr Glu Gly Val Lys Ala Gln Met Ala Phe Arg Gln Ile 290 295 300 Glu Glu Phe Leu Ala Ala Ser Tyr Pro Ile Met Gln Arg Gly Gln Arg 305 310 315 320 Arg Ile Leu Ile Pro Leu Arg Cys Asp Cys Leu Asn Lys Arg Asp Leu 325 330 335 Val Pro Gln Ile Gly Arg Gln Met Cys Lys Leu Thr Pro Phe Ala Leu 340 345 350 Ser Asn Ala Glu Asp Leu Asp Ala Ser Glu Val Thr Asp Pro Thr Ala 355 360 365 Leu Ala Ser Ile His Asn Pro Ser Val Leu Val Phe Gln Cys Ala Asn 370 375 380 Pro Val Phe Arg Asn Ser Arg Gly Gly Ser Gly Pro Asn Cys Asp Phe 385 390 395 400 Lys Ile Ser Ala Pro Asp Val Met Gly Ala Leu Gln Leu Val Arg Gln 405 410 415 Phe Trp Lys Gln Asn Met Glu Asp Val Ala Leu Pro Arg Leu Val Ile 420 425 430 Pro Glu Phe Arg Trp Ser Ala Arg Phe Gln Tyr Arg Asn Val Ser Leu 435 440 445 Pro Ser Gly His Glu Asp Pro Ser Leu Glu Pro Phe Asp Phe 450 455 460 <210> 93 <211> 493 <212> PRT <213> Cynomolgus adenovirus 1 <400> 93 Met Ala Asp Arg Gln Asp Gln Arg Glu Arg Thr Pro Glu Arg Pro Arg 1 5 10 15 Pro Ala Thr Pro Ser Ile Arg Arg Tyr Leu Gln Ala Ser Pro Glu Arg 20 25 30 Ala Pro Thr Pro Ala Pro Pro Gln Lys Lys Ala Arg Lys Ser Leu Leu 35 40 45 Ala Pro Leu Ala Glu Met Pro Pro Ser Pro Glu Ile Val Leu Asp Ser 50 55 60 Asp Asp Glu Glu Asn Leu Ala Ile Ala Glu Glu Ser Gln Ala Gly Val 65 70 75 80 Val Thr Met Val Gly Phe Ser Tyr Pro Pro Val Gln Ile Thr Arg Asn 85 90 95 Pro Asp Gly Ser Arg Ala Phe Lys Lys Leu Pro Pro Pro Pro Leu Pro 100 105 110 Ala Asp Ala Glu Lys Asp Glu Glu Gln Pro Ser Thr Ser Arg Ala Ala 115 120 125 Val Val Val Arg Asn Pro Leu Ser Lys Pro Val Val Ser Ala Trp Glu 130 135 140 Lys Gly Met Ala Val Met His Val Leu Met Asp Lys Tyr Lys Ile Glu 145 150 155 160 Asp Arg Ala Ala Phe His Phe Met Pro Gln Ser Phe Glu Val Tyr Arg 165 170 175 Lys Ile Cys His Thr Trp Leu Gln Glu Asp Leu Lys Tyr Cys Pro Leu 180 185 190 Thr Phe Ser Thr Gln Lys Thr Phe Ser Ala Met Met Gly Arg Phe Leu 195 200 205 Asn Lys Tyr Val Leu Leu His Ala Gly Ile Glu Asn Pro Leu Tyr Lys 210 215 220 Ser Trp Glu Pro Thr Gly Cys Val Val Trp Glu His Arg Cys Thr Glu 225 230 235 240 Gln Glu Gly Gln Leu Met Cys Leu His Gly Leu Pro Met Ile Ala Lys 245 250 255 Asp His Val Val Glu Met Asp Val Ser Ser Glu Ala Gly Gln Arg Ala 260 265 270 Leu Lys Glu Thr Pro Gln Leu Ala Lys Val Val Gln Asn Arg Trp Gly 275 280 285 Arg Asn Val Val Gln Leu Arg His Asp Asn Ala Arg Cys Cys Met Phe 290 295 300 Asp Ala Gln Cys Gly Thr Asn Val Phe Ser Gly Lys Ser Cys Gly Met 305 310 315 320 Phe Tyr Ser Glu Gly Gly Lys Ala Gln Gln Ala Phe Arg Gln Ile Glu 325 330 335 Ala Tyr Met Gln Ala Ala Tyr Pro His Met Gln Arg Gly Gln Lys His 340 345 350 Leu Leu Met Pro Leu Arg Cys Asp Cys Asn Tyr Leu Gly Asp Ala Val 355 360 365 Pro Arg Ala Gly Arg Gln Val Cys Lys Ile Thr Pro Phe Ala Leu Pro 370 375 380 Gly Ala Glu Asp Met Lys His Asp Glu Val Thr Asp Pro Val Ala Leu 385 390 395 400 Ala Ser Leu Asn His Pro Ser Leu Leu Val Phe Gln Cys Ala Asn Pro 405 410 415 Ala Tyr Arg Asn Thr Arg Ala Thr Asn Gln Val Asn Cys Asp Phe Lys 420 425 430 Ile Ser Ala Thr Asp Val Leu Leu Ala Leu Gln Leu Val Arg Asn Leu 435 440 445 Trp His Asp His Phe Val Glu Ala Gly Leu Pro Lys Met Val Leu Pro 450 455 460 Glu Phe Lys Trp Gln Pro Arg Tyr Gln Tyr Lys Asn Leu Thr Leu Pro 465 470 475 480 Thr Ala His Leu Asp Tyr Gln Leu Asn Pro Phe Glu Phe 485 490 <210> 94 <211> 472 <212> PRT <213> Bat adenovirus TJM <400> 94 Met Ser His Val Ile Ser Ser Ser Ser Asp Glu Asp Ile Pro Val Pro 1 5 10 15 Val Arg Lys Arg Gln Arg Lys Ser Lys Glu Asp Ala Lys Ala Arg Ala 20 25 30 Lys Glu Ser Pro Arg Pro Glu Lys Glu Asp Ser Ser Leu Val Gly His 35 40 45 Gly Tyr Ala Leu Glu Met Thr Arg Arg Ala Asn Ala Ile Leu Glu Ala 50 55 60 Gln Gly Lys Pro Gly Gly Phe Tyr Ile Gln Thr Phe Cys Gly Gln Arg 65 70 75 80 Val Glu Lys Asp Ala Asn Gly Glu Ile Gln Phe Ile Lys Gln Asp Pro 85 90 95 Pro Ser Ala Pro Pro Leu Pro Met Asp Pro Ala Leu Lys Ala Gln Leu 100 105 110 Met Glu Pro Leu Ile Gln Ala Ala Val Asp Met Arg Pro Thr Lys Ala 115 120 125 Asn Glu His Gln Trp Gln Leu Gly Met Glu Met Ala Leu Lys Ile Leu 130 135 140 Thr Ala Tyr Gln Val Asp His Lys Glu Leu Thr Leu Leu Pro Asp Ser 145 150 155 160 Gly Thr Leu Glu Cys Phe Lys Lys Ala Ala Gln Ala Tyr Leu Val Asn 165 170 175 Thr Lys Thr Val Val Thr Tyr Asn Phe Thr Thr Gln Lys Ser Phe Gln 180 185 190 His Met Val Gly Arg Ile Leu Leu Asp Phe Val Ile Lys Ala Ala Gly 195 200 205 Val Ala Pro Gly Leu Asn Pro Ser Gly Cys Val Val Trp Gln His Gly 210 215 220 Cys Gln Arg Gln Leu His Cys Leu His Gly Ser Pro Met Ile Gln Lys 225 230 235 240 Glu Gln Leu Ile Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Val 245 250 255 Leu Lys Glu Asn Pro Glu Lys Thr Lys Ile Val Thr Asn Arg Trp Gly 260 265 270 Arg Asn Val Val Gln Met Lys Asn Glu Asp Ala Tyr Cys Cys Phe Met 275 280 285 Asp Val Asn Ile Ser Gly Gly Asn Phe Ser Ser Ser Ser Cys Gly Met 290 295 300 Ser Tyr Thr Asp Gly Pro Lys Ala Leu Met Ala Phe Gln Gln Ile Met 305 310 315 320 Ala Phe Gln Arg Ala Cys Tyr Pro Gln Met Ser Thr Ala Glu Ser His 325 330 335 Leu Leu Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Asn Ser Leu Pro 340 345 350 Met Leu Gly Arg Gln Thr Cys Lys Met Thr Pro Tyr Ala Leu Ser Ser 355 360 365 Thr Ala Asp Ile Asp Arg Ser Leu Val Gln Asp Ala Lys Met Leu Ala 370 375 380 Thr Leu Asp His Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val 385 390 395 400 Tyr Arg Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile 405 410 415 Ser Thr Val Asp Met Val Ala Cys Val Gln Ile Ala Lys Lys Ile Trp 420 425 430 Ser Thr Cys Ile Gly Thr Pro Pro Pro Leu Lys Phe Pro Glu Phe Lys 435 440 445 Trp Ser Gln Glu Tyr Lys Tyr Gln Thr Thr Ile Leu Pro Gln Gly Gln 450 455 460 Glu Asp Asn Asp Val Ser Leu Phe 465 470 <210> 95 <211> 454 <212> PRT <213> Canine adenovirus 1 <400> 95 Met Ser His Lys Lys Val Val Ala Ile Ser Glu Ser Ser Ser Asp Glu 1 5 10 15 Glu Val Pro Val Ala Pro Pro Thr Ala Pro Pro Lys Lys Arg Gln Arg 20 25 30 Lys Ala Val Glu Glu Pro Arg Gly His Gln Ala Met Val Glu Ile Ala 35 40 45 Arg Gln Ala Thr Ala Ala Leu Lys Ala Arg Gly Asp Pro Gly Ser Ile 50 55 60 Ile Val Gln Thr Phe Cys Asp Gln Thr Val Asp Val Asp Lys Glu Gly 65 70 75 80 Asn Val Ile Phe Thr Pro Ala Lys Gln Lys Ser Ile Cys Asn Lys Ser 85 90 95 Gly Ser Pro Leu Ala Ser Val Ala Ser Lys Ile Phe Lys Ala Ser Glu 100 105 110 His Lys Trp Gln Ser Ala Met Glu Phe Ala Leu Lys Val Leu Asn Ala 115 120 125 Tyr Gln Val Asp His Ser Lys Leu Thr Leu Leu Pro Asp Glu Gly Thr 130 135 140 Leu Glu Cys Phe Lys Lys Ala Val Gln Ala Tyr Ile Thr Thr Ser Lys 145 150 155 160 Met His Val Thr Tyr Thr Phe Thr Asn Gln Lys Thr Phe Leu His Val 165 170 175 Ala Gly Arg Leu Leu Leu Asp Phe Val Ile Lys Ala Ala Glu Leu Ala 180 185 190 Pro Gly Val Asn Pro Ser Gly Cys Val Val Trp Gln His Gly Cys Gln 195 200 205 Ser Ser Leu Met Cys Leu His Gly Ser Pro Met Ile Gln Lys Glu Gln 210 215 220 Leu Val Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Ala Leu Lys 225 230 235 240 Glu Asn Pro Glu Lys Thr Lys Ile Val Ser Asn Arg Trp Gly Arg Asn 245 250 255 Val Val Gln Phe Lys Asn Glu Asp Ala Phe Cys Cys Ser Met Asp Val 260 265 270 Asn Met Ser Gly Gly Asn Phe Ser Gly Ala Ser Cys Gly Met Phe Tyr 275 280 285 Thr Asp Gly Pro Lys Ala Ile Met Ala Phe Gln Gln Ile Met Ala Phe 290 295 300 Leu Lys Ala Cys Tyr Pro Ser Met Pro Asn Ala Glu Ser His Leu Leu 305 310 315 320 Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Ser Ser Leu Pro Leu Leu 325 330 335 Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ser Leu Ala Ser Ala Asn 340 345 350 His Ile Asp Lys Ser Glu Val Asp Asp Gln Lys Met Leu Ala Thr Leu 355 360 365 Asn Asn Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg 370 375 380 Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ser 385 390 395 400 Val Asp Leu Val Ser Cys Leu Gln Ile Ala Lys Gln Ile Trp Leu Ser 405 410 415 Thr Val Gly Glu Lys Pro Pro Val Lys Phe Pro Glu Phe His Trp Ser 420 425 430 Asp Glu His Arg Tyr Gln Thr Thr Ile Leu Pro Gln Gly Gln His Asp 435 440 445 Asp Asp Leu Val Leu Phe 450 <210> 96 <211> 454 <212> PRT <213> Canine adenovirus 2 <400> 96 Met Ser His Lys Lys Val Val Ala Ile Ser Glu Ser Ser Ser Asp Glu 1 5 10 15 Glu Val Pro Val Ala Pro Pro Thr Ala Pro Pro Lys Lys Arg Gln Arg 20 25 30 Lys Ala Val Glu Glu Pro Arg Gly His Gln Ala Met Val Glu Ile Ala 35 40 45 Arg Gln Ala Thr Ala Thr Leu Lys Ala Arg Gly Asp Pro Gly Ser Ile 50 55 60 Val Val Gln Thr Phe Cys Gly Gln Thr Val Asp Thr Asp Lys Glu Gly 65 70 75 80 Asn Val Val Phe Ile Pro Pro Lys Gln Lys Ser Val Trp Ser Lys Pro 85 90 95 Asn Ala Pro Ser Gly Leu Val Ala Ser Lys Phe Phe Lys Ala Ser Glu 100 105 110 His Lys Trp Gln Ser Ala Met Glu Leu Ala Leu Lys Val Leu Thr Ala 115 120 125 Tyr Gln Val Asp His Ser Lys Leu Thr Leu Leu Pro Asp Glu Gly Thr 130 135 140 Leu Glu Cys Phe Lys Lys Ala Val Gln Ala Tyr Ile Thr Thr Ser Lys 145 150 155 160 Thr His Val Thr Tyr Thr Phe Thr Asn Gln Lys Thr Phe Leu His Val 165 170 175 Ala Gly Arg Leu Leu Leu Asp Phe Val Ile Lys Ala Ala Glu Leu Ala 180 185 190 Pro Gly Val Asn Pro Ser Gly Cys Val Val Trp Gln His Gly Cys Gln 195 200 205 Ser Ser Leu Met Cys Leu His Gly Ser Pro Met Ile Gln Lys Glu Gln 210 215 220 Leu Val Glu Met Asp Val Asn Ser Glu Asn Ala Gln Arg Ala Leu Lys 225 230 235 240 Glu Asn Pro Glu Lys Thr Lys Ile Val Ser Asn Arg Trp Gly Arg Asn 245 250 255 Val Val Gln Phe Lys Asn Glu Asp Ala Phe Cys Cys Ser Met Asp Val 260 265 270 Asn Met Ser Gly Gly Asn Phe Ser Gly Ala Ser Cys Gly Met Phe Tyr 275 280 285 Thr Asp Gly Pro Lys Ala Ile Met Ala Phe Gln Gln Ile Met Ala Phe 290 295 300 Leu Lys Ala Cys Tyr Pro Ser Met Pro Asn Ala Glu Ser His Leu Leu 305 310 315 320 Met Pro Leu Lys Cys Glu Cys Asn Trp Asn Ser Asn Leu Pro Leu Leu 325 330 335 Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ser Leu Ala Ser Ala Ser 340 345 350 His Ile Asp Lys Ser Glu Val Asp Asp Gln Lys Met Leu Ala Thr Leu 355 360 365 Asn Asn Pro Ala Met Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg 370 375 380 Asn Ser Lys Ala Ala Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ser 385 390 395 400 Val Asp Leu Val Ser Cys Val Gln Ile Ala Lys Gln Ile Trp Thr Ser 405 410 415 Thr Val Gly Glu Arg Pro Pro Ile Lys Phe Pro Glu Phe His Trp Ser 420 425 430 Asp Glu His Arg Tyr Gln Asn Thr Ile Leu Pro Gln Gly Gln His Asp 435 440 445 Asp Asp Leu Val Leu Phe 450 <210> 97 <211> 435 <212> PRT <213> Bovine adenovirus 10 <400> 97 Met Ser Gln Glu Ser Gln Asn Asp Phe Leu Thr Asn Glu Ser Val Phe 1 5 10 15 Met Asp Glu Asn Val Ala Lys Lys Ala Arg Lys Arg Pro Leu Ser Val 20 25 30 Ile Asn Thr Glu Ala Val Glu Asp Ile Glu Glu Ile Glu Glu Met Phe 35 40 45 Ser Val Gly Phe Ser Asn Pro Pro Cys Lys Leu Gly Pro Lys Gln Ile 50 55 60 Val Lys Lys Lys Ala Gly Phe Leu Thr Gly Gly Gln Leu Ser Cys Lys 65 70 75 80 Lys Ser Lys Thr Val Glu Glu Val Asp Trp Gln Lys Ala Met Asp Leu 85 90 95 Ala Val Gln Ile Leu Gln Pro Leu Lys Val Asp Ile Lys Glu Leu Thr 100 105 110 Leu Val Pro Asp Ala Tyr Lys Phe Arg Asn Phe Arg Lys Ala Met Pro 115 120 125 Lys Leu Gly Cys Asn Asp Lys Lys Ile His Leu Asn Leu Thr Phe Ser 130 135 140 Thr Gln Lys Thr Val Thr Thr Leu Met Gly Arg Phe Ile Phe Ser Phe 145 150 155 160 Val Leu Arg Ala Gly Gly Met Ala Pro Ser Asn Trp Asn Pro Thr Gly 165 170 175 Cys Val Ile Trp Asn His Lys Cys Leu Asp Asn Leu Lys Cys Phe His 180 185 190 Gly Leu Thr Met Val Ser Lys Asp Gln Leu Val Glu Met Asp Val Thr 195 200 205 Ser Glu Asn Ala Gln Arg Ala Leu Lys Glu Thr Pro Gln Lys Ala Lys 210 215 220 Ile Thr Thr Asn Arg Trp Gly Arg Ser Ile Val Gln Leu Lys Asn Glu 225 230 235 240 Asp Ala Ala Cys Cys Phe His Asp Ala Ser Cys Asn Ala Gly Thr Phe 245 250 255 Ser Asn Lys Ser Cys Gly Leu Phe Tyr Thr Glu Gly Gln Lys Ala Leu 260 265 270 Gln Ala Phe Lys Gln Ile Met Glu Phe Gln Lys Ala Cys Tyr Pro Lys 275 280 285 Met Ala Asn Ala Met Ser His Leu Leu Leu Pro Ile Lys Cys Asp Cys 290 295 300 Asn Trp Gly Thr Gly Tyr Met Pro Leu Leu Gly Arg Gln Met Cys Lys 305 310 315 320 Val Thr Pro Phe Ser Met Ser Gly Gly Arg Leu Ile Val Glu Lys His 325 330 335 Leu Ile Asp Arg Ile Pro Lys Leu Leu Ala Tyr Leu Cys Asn Asn Pro 340 345 350 Ser Ile Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg His Ser Lys 355 360 365 Ala Asn Pro Gln Lys Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Val 370 375 380 Ile Leu Ala Leu Gln Leu Ala Lys Gln Met Trp Ser Ser Leu Ile Asn 385 390 395 400 Cys Pro Val Pro Leu Val Leu Glu Glu Phe Lys Trp Gln Thr Gln Tyr 405 410 415 Gln Tyr Gln Asn Thr Ile Leu Pro Val Ala Tyr Val Asp Thr Asp Glu 420 425 430 Ser Leu Phe 435 <210> 98 <211> 441 <212> PRT <213> Porcine adenovirus 5 <400> 98 Met Arg Phe Val Thr Phe Phe Ser Ile Leu His Leu Glu Lys Met Ser 1 5 10 15 Arg Asn His Tyr Glu Asp Val Ser Asp Ser Ser Ala Asp Asp Glu Pro 20 25 30 Arg Leu Val Ile Asp Asp Gln Pro Lys Pro Lys Lys Ile Ala Arg Arg 35 40 45 Arg Lys Ala Asp Gly Asp Lys Leu Asp Gly Ala Ala Lys Ser His Asp 50 55 60 Glu Ser Asn Lys Lys Arg Ala Arg Val Leu Ser Asp Thr Asp Glu Glu 65 70 75 80 Thr Pro Ser Thr Ser Val Lys Ser Ser Lys Leu Leu Leu Asp Arg Asn 85 90 95 Glu Val Lys Trp Gln Lys Ala Met Asp Val Ala Met Ser Leu Met Val 100 105 110 Pro Leu Lys Val Asp Thr Lys Asp Leu Thr Leu Leu Pro Asp His Ala 115 120 125 Thr Met Glu Cys Phe Lys Lys Ala Ala Gln Ala Trp Met Ser Asp Arg 130 135 140 Lys Lys Phe Ile Gln Leu Thr Phe Ser Thr Gln Lys Ser Leu Leu Thr 145 150 155 160 Val Met Ala Arg Phe Leu Phe Asp Phe Val Ile Arg Glu Ala Glu Leu 165 170 175 Asn Thr Pro Asp Trp Asn Pro Thr Gly Cys Val Val Trp Asn His Lys 180 185 190 Cys Gly Asp Arg Leu His Cys Leu His Gly Met Ala Met Ile Asn Lys 195 200 205 Glu Gln Leu Val Glu Met Asp Ile Asn Ser Glu Asn Gly Gln Arg Ala 210 215 220 Leu Lys Glu Thr Pro Glu Lys Ala Lys Ile Val Thr Asn Arg Trp Gly 225 230 235 240 Arg Ser Val Val Gln Ile Arg Asn Ser Asp Ala Met Cys Cys Val Asn 245 250 255 Asp Ala Lys Ser Pro Ile Asn Thr Phe Ser Pro Gln Ser Cys Gly Tyr 260 265 270 Phe Tyr Ser Asp Gly Pro Lys Ala Val Thr Ala Phe Arg Gln Ile Ala 275 280 285 Ala Phe Val Lys Ala Ile Tyr Pro Asn Met Ala Thr Ala Glu Ser His 290 295 300 Leu Leu Met Pro Leu Val Cys Glu Cys Asn Tyr Gly Ala Asn His Leu 305 310 315 320 Pro Leu Leu Gly Lys Gln Thr Cys Lys Val Thr Pro Phe Ala Met Ser 325 330 335 Thr Ala Gly Asn Ile Asp Arg Asn Leu Ile Asp Asp Pro Lys Val Leu 340 345 350 Ala Thr Leu Asp His Pro Ala Val Leu Val Phe Gln Cys Cys Asn Pro 355 360 365 Val Phe Arg Asn Thr Lys Ala Asn Pro Gln Lys Asn Cys Asp Phe Lys 370 375 380 Ile Ser Ser Thr Asp Val Val Ser Ala Leu Gln Leu Ala Lys Gln Met 385 390 395 400 Trp Gln Asn Ile Ile Gly Thr Lys Val Asn Leu Ser Val Pro Glu Phe 405 410 415 Arg Trp His Pro Gln Tyr Gln Val Gln Asn Thr Ile Leu Pro Thr Gly 420 425 430 Gln His Asp Asp Asp Asp Cys Leu Phe 435 440 <210> 99 <211> 442 <212> PRT <213> Ovine adenovirus A <400> 99 Met Ser Gln Asn His Tyr Glu Asp Ile Phe Asp Ser Asp Glu Glu Gly 1 5 10 15 Lys Leu Val Ile Asp Glu Thr Pro Arg Val Lys Lys Val Thr Lys Arg 20 25 30 Lys Lys Ala Thr Glu Asp Ile Thr Pro Pro Thr Thr Pro Asp Ile Val 35 40 45 Glu Pro Ala Ser Ser Lys Lys Val Arg Val Ile Glu Ser Asp Asp Glu 50 55 60 Ala Pro Ser Thr Ser Lys Gly Lys Lys Arg Ser Val Val Ser Lys Pro 65 70 75 80 Asn Val Ser Pro Ala Ala Lys Ile Ser Arg Lys Leu Leu Asp Gln Asn 85 90 95 Glu Met Lys Trp Gln Lys Ala Met Asp Val Ala Val Ser Phe Leu Val 100 105 110 Pro Leu Lys Val Asp Ile Lys Asp Leu Thr Leu Leu Pro Asp Ala Gly 115 120 125 Thr Met Glu Cys Phe Arg Lys Gly Val Gln Ser Trp Leu Asn Glu Gln 130 135 140 Lys Arg Phe Val Pro Leu Thr Phe Ser Thr Gln Lys Ser Leu Gln Thr 145 150 155 160 Ala Val Ala Arg Phe Val Phe Asp Phe Val Leu Arg Ala Ala Glu Ile 165 170 175 Cys Pro Ala Asp Trp Asn Pro Asn Gly Cys Val Val Trp Glu His Lys 180 185 190 Thr Asn Glu Glu Lys Leu Tyr Cys Leu His Gly Leu Pro Met Ile Asn 195 200 205 Lys Glu Gln Ile Val Glu Met Asp Ile Asn Ser Glu Asn Gly Gln Arg 210 215 220 Ala Leu Lys Glu Ser Pro Glu Arg Ala Lys Ile Val Thr Asn Lys Trp 225 230 235 240 Gly Arg Ser Val Val Gln Met Lys Asn Ala Asp Ala Met Cys Cys Phe 245 250 255 Tyr Asp Leu Lys Ser Ser Leu Asn Ser Phe Ser Ser Glu Ser Cys Gly 260 265 270 Tyr Phe Tyr Ser Asp Gly Asn Lys Ala Arg Gln Gly Phe Tyr Gln Ile 275 280 285 Arg Asp Phe Val Lys Ala Met Tyr Pro Gln Met Pro Lys Ala Gly Glu 290 295 300 Met Leu Leu Met Pro Leu Val Cys Glu Cys Asn Tyr Gly His His Val 305 310 315 320 Ile Pro Leu Leu Gly Lys Gln Thr Cys Lys Val Thr Pro Phe Ala Leu 325 330 335 Asn Ala Val Ser Asn Ile Asp Arg Ser Leu Val Glu Asp Ala Lys Val 340 345 350 Leu Ala Thr Leu Asn Asn Pro Val Val Leu Val Phe Gln Cys Cys Asn 355 360 365 Pro Val Phe Arg Asn Thr Lys Ala Asn Pro Gln Lys Asn Cys Asp Phe 370 375 380 Lys Ile Ser Ser Thr Asp Val Val Met Ala Leu Gln Leu Ala Lys Gln 385 390 395 400 Met Trp Ser Ser Leu Thr Gly Thr Lys Ala Ser Ile Val Val Gln Glu 405 410 415 Phe Lys Trp Gln Pro Gln Tyr Arg Val Gln Asn Thr Leu Leu Pro Thr 420 425 430 Gly Gln Asp Asp Ala Asp Glu Cys Leu Phe 435 440 <210> 100 <211> 457 <212> PRT <213> Porcine adenovirus 3 <400> 100 Met Ser Arg Arg Tyr Ser Asp Val Ser Asp Tyr Asp Ser Gly Glu Glu 1 5 10 15 Gly Val Leu Ile Val Asp Asp Ala Pro Val Ala Thr Pro Ser Arg Arg 20 25 30 Gly Gly Gly Arg Lys Arg Ala Ala Ser Pro Pro Val Gln Glu Arg Arg 35 40 45 Lys Arg Ala Arg Ala Lys Pro Leu Val Ser Glu Glu Glu Glu Asp Glu 50 55 60 Ala Glu Glu Thr Ala Ala Ala Thr Ala Arg Pro Ala Arg Arg Lys Gly 65 70 75 80 Glu Asp Gly Glu Glu Glu Glu Gly Ala Arg Pro Pro Arg Pro Val Thr 85 90 95 Pro Ser Pro Ala Val Ala Arg Pro Leu Leu Gln Leu Asp Ala Gln Glu 100 105 110 Gln Lys Trp Gln Arg Ala Met Asp Leu Ala Val Gln Met Leu Val Pro 115 120 125 Leu Lys Val Asp Val Lys Gly Leu Thr Leu Leu Pro Asp Gly Ser Thr 130 135 140 Leu Glu Cys Phe Arg Arg Gly Ala Gln Ala Trp Leu Asn Glu Arg Lys 145 150 155 160 Ile Ser Cys Gln Leu Thr Phe Ser Thr Gln Lys Ser Leu Leu Thr Val 165 170 175 Met Ala Arg Phe Leu Leu Asp Phe Val Val Lys Ala Ala Gly Leu Lys 180 185 190 Thr Pro Glu Trp Asn Pro Cys Gly Cys Val Ile Trp Gln His Arg Ser 195 200 205 Gly Ser Glu Gly Leu His Cys Leu His Gly Leu Pro Met Ile Asn Lys 210 215 220 Glu Gln Leu Val Glu Met Asp Leu Asn Ser Glu Asn Gly Gln Arg Ala 225 230 235 240 Leu Arg Glu Thr Pro Glu Arg Ala Lys Ile Thr Thr Asn Arg Trp Gly 245 250 255 Arg Asn Val Val Gln Leu Arg Asn Asp Gly Ala Met Cys Cys Ser His 260 265 270 Asp Val Gly Ser Ala Pro Asn Thr Phe Ser Ala Arg Ser Cys Gly Leu 275 280 285 Phe Tyr Ser Glu Gly Ser Lys Ala Gln Gln Ala Phe Glu Gln Leu Lys 290 295 300 Ala Phe Gln Lys Ala Cys Tyr Pro Arg Met Gly Asn Ala Glu Thr His 305 310 315 320 Leu Leu Met Pro Leu Val Cys Asp Cys Gly Trp Gly Cys Arg Gln Val 325 330 335 Pro Leu Leu Gly Arg Gln Thr Cys Lys Ile Thr Pro Phe Ala Leu Ser 340 345 350 Gly Ser Ala Ala Leu Asn Pro Gln Leu Val Glu Asp Pro Lys Ile Leu 355 360 365 Ala Ser Val Thr His Pro Ala Val Leu Val Phe Gln Cys Tyr Asn Pro 370 375 380 Val Tyr Arg Gly Ser Arg Gly Asn Pro Gln Lys Asn Cys Asp Phe Lys 385 390 395 400 Ile Ser Ala Pro Asp Val Met Leu Ala Leu Gln Leu Thr Lys Gln Met 405 410 415 Trp Ala Ala Leu Met Gln Thr Arg Pro Pro Leu Thr Val Pro Glu Phe 420 425 430 Lys Trp Gly Pro Gln Phe Gln Val Gln Asn Thr Ile Phe Pro Val Gly 435 440 445 Thr Glu Asp Asp Asp Glu Ser Leu Phe 450 455 <210> 101 <211> 432 <212> PRT <213> Bovine adenovirus B <400> 101 Met Asn Arg Ser Gly Asp Leu Thr Arg Ala Thr Ser Ser Ala Asp Ser 1 5 10 15 Ser Gly Asp Glu Asn Pro Leu Val Ile Asp Glu Thr Pro Arg Lys Lys 20 25 30 Val Ser Arg Lys Arg Arg Ala Pro Ile Ala Glu Pro Pro Ala Glu Asp 35 40 45 Val Thr Ala Val Lys Arg Ala Lys Ile Phe Lys Pro Ser Ala Pro Ala 50 55 60 Ala Glu Ala Ala Ala Pro Ala Leu Pro Ala Ala Ser Arg Ala Leu Leu 65 70 75 80 Glu Ala Asp Glu Val Ala Trp Gln Arg Ala Met Glu Leu Ala Val Gly 85 90 95 Leu Cys Val Pro Leu Lys Val Asp Ile Lys Asn Leu Thr Leu Leu Pro 100 105 110 Asp Thr Gly Thr Leu Glu Cys Phe Arg Lys Val Ala Gln Ala Trp Leu 115 120 125 Asn Glu Ser Lys Val Tyr Leu Pro Leu Thr Phe Ser Thr Gln Lys Thr 130 135 140 Val Leu Thr Ile Met Gly Arg Phe Leu Tyr Asp Phe Val Leu Lys Val 145 150 155 160 Ala Gly Leu Gly Thr Thr Ser Trp Ser Pro Thr Gly Cys Val Val Trp 165 170 175 Arg His Gln Cys Thr Glu Gly Gly Asp Gly Ala Leu His Cys Leu His 180 185 190 Gly Leu Pro Met Leu Thr Lys Asp Gln Val Ile Glu Met Asp Val Asn 195 200 205 Ser Glu Asn Gly Gln Arg Ala Leu Lys Glu Thr Pro His Lys Thr Lys 210 215 220 Ile Thr Thr Asn Arg Trp Asn Met Asn Val Val Gln Leu Lys Asn Glu 225 230 235 240 Asp Ala Ala Cys Cys His Phe Asp Ala Ala Leu Pro Ala Gly Ser Phe 245 250 255 Thr Ser Lys Ser Cys Gly Met Phe Phe Ser Glu Gly Pro Lys Ala Leu 260 265 270 Gln Ala Phe Trp Gln Ile Met Thr Phe Gln Lys Ala Cys Tyr Pro Arg 275 280 285 Met Gln Ser Ala Gly Thr His Leu Leu Met Pro Leu Lys Cys Asp Cys 290 295 300 Asn Trp Gly His Ser Gln Leu Pro Leu Leu Gly Arg Gln Val Cys Lys 305 310 315 320 Ile Thr Pro Phe Asn Ile Asn Ala Gly Ser Ala Val Asp Lys Ser Leu 325 330 335 Val Glu Asp Pro Lys Leu Leu Ala Ser Val Glu His Pro Ser Val Leu 340 345 350 Val Phe Gln Cys Cys Asn Pro Val Tyr Arg Gln Thr Arg Ala Asn Ala 355 360 365 Gln Arg Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Met Ile Ser Ala 370 375 380 Leu Gln Leu Val Lys Gln Met Trp Ser Ala Leu Val Lys Gln Ser Pro 385 390 395 400 Pro Ile Thr Ile Pro Glu Phe Arg Trp Asp Pro Gln Tyr Gln His Gln 405 410 415 Asn Val Ile Leu Pro Ile Asp Gln Tyr Asp Ala Asp Asp Ser Leu Phe 420 425 430 <210> 102 <211> 467 <212> PRT <213> Tree shrew adenovirus <400> 102 Met Ser Asp Arg His Asp Tyr Ser Ser Asp Ser Ser Ser Asp Met Ile 1 5 10 15 Ile Cys Glu Asn Glu Pro Ala Pro Lys Glu Thr Gln Gly Pro Ser Val 20 25 30 Met Arg Val Gly Phe Ser Asn Pro Pro Val Glu Ile Ile Arg Ser Gly 35 40 45 Gly Gly Lys Thr Thr His Lys Ser Leu Gly Pro Asn Trp Arg Arg Lys 50 55 60 Leu Pro Ser Leu Asp Gln Leu Met Lys Gly Glu Pro Ala Asp Glu Ser 65 70 75 80 Ser Gln Asp Ser Thr Lys Ser Ser Pro Glu Lys Arg Pro Ser Thr Ser 85 90 95 Gly Glu Pro Ala Ala Ile Lys Lys Arg Arg Lys Ala Val Val Pro Asn 100 105 110 Lys Leu Val Ser Ser Asp Glu Thr Lys Trp Gln Met Val Met Asp Met 115 120 125 Ala Val Asn Met Leu Thr Pro Leu Lys Val Asp Leu Lys Asp Leu Thr 130 135 140 Met Leu Ala Asp Gln Gly Thr Leu Glu Cys Phe Gln Lys Ala Ala Gln 145 150 155 160 Ala Trp Met Thr Glu Arg Lys Ile Tyr Thr Pro Leu Thr Tyr Ser Thr 165 170 175 Gln Lys Thr Leu Leu Ser Leu Met Gly Arg Phe Leu Phe His Phe Ile 180 185 190 Met Thr Lys Val Gly Glu Ser Asp His Gly Gly Lys Ala Trp Pro Lys 195 200 205 Asn Thr Asn Val Ser Gly Ala Val Val Trp Lys His Gln Ser Gly Ala 210 215 220 Thr Leu Ser Cys Leu His Gly Leu Thr Met Leu Asn Lys Glu Gln Ile 225 230 235 240 Val Glu Met Asp Val Ser Ser Glu Asn Gly Gln Arg Ala Leu Lys Glu 245 250 255 Thr Pro Glu Lys Thr Lys Ile Thr Thr Asn Arg Trp Gly Arg Asn Val 260 265 270 Val Gln Val Arg Asn Glu Asp Ala Met Cys Cys Gln Phe Asp Ala Pro 275 280 285 Leu Pro Ala Asn Asn Phe Ser Thr Lys Ser Cys Gly Met Phe Tyr Ser 290 295 300 Glu Gly Glu Lys Ala Lys Thr Ala Phe Lys Gln Ile Met Ala Leu Gln 305 310 315 320 Arg Ala Cys Tyr Pro Lys Met Asp Gly Glu Gln Ile Val Ile Pro Ile 325 330 335 Lys Cys Asp Cys Asn Trp Ala Ser Thr Thr Pro Leu Leu Gly Arg Gln 340 345 350 Val Cys Lys Val Thr Pro Phe Thr Ile Ser Ala Thr Glu Ser Ile Asp 355 360 365 Arg Glu Leu Val Gln Asp Pro Lys Ile Leu Ala Thr Val His Asn Pro 370 375 380 Ala Val Leu Val Phe Gln Cys Cys Asn Pro Val Tyr Arg Asn Ser Arg 385 390 395 400 Ala Asn Pro Gln Lys Asn Cys Asp Trp Lys Ile Ser Ala Pro Asp Val 405 410 415 Met Thr Ala Leu Gln Leu Ala Lys Gln Met Trp Gln His Val Phe Lys 420 425 430 Glu Pro Pro Val Val Arg Ile Pro Glu Phe Lys Trp Ser Ala Ala Tyr 435 440 445 Gln Tyr Gln Asn Thr Ile Leu Pro Thr Gly Val Asp Asp Thr Asp Asp 450 455 460 Ser Leu Phe 465 <210> 103 <211> 529 <212> PRT <213> Human adenovirus 5 <400> 103 Met Ala Ser Arg Glu Glu Glu Gln Arg Glu Thr Thr Pro Glu Arg Gly 1 5 10 15 Arg Gly Ala Ala Arg Arg Pro Pro Thr Met Glu Asp Val Ser Ser Pro 20 25 30 Ser Pro Ser Pro Pro Pro Pro Arg Ala Pro Pro Lys Lys Arg Met Arg 35 40 45 Arg Arg Ile Glu Ser Glu Asp Glu Glu Asp Ser Ser Gln Asp Ala Leu 50 55 60 Val Pro Arg Thr Pro Ser Pro Arg Pro Ser Thr Ser Ala Ala Asp Leu 65 70 75 80 Ala Ile Ala Pro Lys Lys Lys Lys Lys Arg Pro Ser Pro Lys Pro Glu 85 90 95 Arg Pro Pro Ser Pro Glu Val Ile Val Asp Ser Glu Glu Glu Arg Glu 100 105 110 Asp Val Ala Leu Gln Met Val Gly Phe Ser Asn Pro Pro Val Leu Ile 115 120 125 Lys His Gly Lys Gly Gly Lys Arg Thr Val Arg Arg Leu Asn Glu Asp 130 135 140 Asp Pro Val Ala Arg Gly Met Arg Thr Gln Glu Glu Glu Glu Glu Pro 145 150 155 160 Ser Glu Ala Glu Ser Glu Ile Thr Val Met Asn Pro Leu Ser Val Pro 165 170 175 Ile Val Ser Ala Trp Glu Lys Gly Met Glu Ala Ala Arg Ala Leu Met 180 185 190 Asp Lys Tyr His Val Asp Asn Asp Leu Lys Ala Asn Phe Lys Leu Leu 195 200 205 Pro Asp Gln Val Glu Ala Leu Ala Ala Val Cys Lys Thr Trp Leu Asn 210 215 220 Glu Glu His Arg Gly Leu Gln Leu Thr Phe Thr Ser Asn Lys Thr Phe 225 230 235 240 Val Thr Met Met Gly Arg Phe Leu Gln Ala Tyr Leu Gln Ser Phe Ala 245 250 255 Glu Val Thr Tyr Lys His His Glu Pro Thr Gly Cys Ala Leu Trp Leu 260 265 270 His Arg Cys Ala Glu Ile Glu Gly Glu Leu Lys Cys Leu His Gly Ser 275 280 285 Ile Met Ile Asn Lys Glu His Val Ile Glu Met Asp Val Thr Ser Glu 290 295 300 Asn Gly Gln Arg Ala Leu Lys Glu Gln Ser Ser Lys Ala Lys Ile Val 305 310 315 320 Lys Asn Arg Trp Gly Arg Asn Val Val Gln Ile Ser Asn Thr Asp Ala 325 330 335 Arg Cys Cys Val His Asp Ala Ala Cys Pro Ala Asn Gln Phe Ser Gly 340 345 350 Lys Ser Cys Gly Met Phe Phe Ser Glu Gly Ala Lys Ala Gln Val Ala 355 360 365 Phe Lys Gln Ile Lys Ala Phe Met Gln Ala Leu Tyr Pro Asn Ala Gln 370 375 380 Thr Gly His Gly His Leu Leu Met Pro Leu Arg Cys Glu Cys Asn Ser 385 390 395 400 Lys Pro Gly His Ala Pro Phe Leu Gly Arg Gln Leu Pro Lys Leu Thr 405 410 415 Pro Phe Ala Leu Ser Asn Ala Glu Asp Leu Asp Ala Asp Leu Ile Ser 420 425 430 Asp Lys Ser Val Leu Ala Ser Val His His Pro Ala Leu Ile Val Phe 435 440 445 Gln Cys Cys Asn Pro Val Tyr Arg Asn Ser Arg Ala Gln Gly Gly Gly 450 455 460 Pro Asn Cys Asp Phe Lys Ile Ser Ala Pro Asp Leu Leu Asn Ala Leu 465 470 475 480 Val Met Val Arg Ser Leu Trp Ser Glu Asn Phe Thr Glu Leu Pro Arg 485 490 495 Met Val Val Pro Glu Phe Lys Trp Ser Thr Lys His Gln Tyr Arg Asn 500 505 510 Val Ser Leu Pro Val Ala His Ser Asp Ala Arg Gln Asn Pro Phe Asp 515 520 525 Phe <210> 104 <211> 215 <212> PRT <213> Murine adenovirus 1 <400> 104 Met Ser Ala Pro Ser Pro Tyr Val Trp Thr Phe Gln Pro Gln Arg Gly 1 5 10 15 Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Ile Asn Trp Leu 20 25 30 Ser Ala Gly Pro Glu Leu Arg Gly Lys Val Val Gln Leu Asn Glu Ala 35 40 45 Arg Asn Ala Ile Leu Met Lys Glu Gln Glu Ser Val Pro Thr Pro Arg 50 55 60 Ala Glu Ala Asn Pro Ser Phe Trp Pro Ala Ala Leu Ile Phe Gln Pro 65 70 75 80 Arg Pro Gln Ala Ile Pro Val His Pro Ala His Pro Asp Thr Phe Asp 85 90 95 Ala Ala Leu Thr Ser Asn Gly Ala Gln Leu Ala Gly Gly Ala Trp Ile 100 105 110 Asn Tyr Lys Asn Gly Ser Val Arg Tyr Glu Ala Pro Leu Gln Leu Ala 115 120 125 Glu Glu Gln Val Gly Gly Pro Leu Asn Ala Phe Ala Ile Lys His Gln 130 135 140 Leu Gln Leu Ala Gly Gly Ala Leu Ser Ala Ser Met Ser Glu Met Ser 145 150 155 160 Gly Ala Pro Arg Ile Pro Arg Ser Gly Gly Ile Gly Ser Trp Gln Phe 165 170 175 Ser Arg Glu Phe Pro Pro Thr Val Tyr Leu Asn Pro Phe Ser Gly Ser 180 185 190 Pro Asp Thr Phe Pro His Gln Phe Leu Ser Asn Tyr Asp Ser Phe Ser 195 200 205 His Thr Val Asp Gly Tyr Asp 210 215 <210> 105 <211> 218 <212> PRT <213> Murine adenovirus 3 <400> 105 Met Ser Ala Pro Ser Pro Tyr Met Trp Thr Phe Gln Pro Gln Arg Gly 1 5 10 15 Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Leu Asn Trp Leu 20 25 30 Ser Ala Gly Pro Ser Leu Arg Gly Lys Val Ile Glu Val Asn Gln Ala 35 40 45 Arg Asn Ser Ile Leu Leu Asn Gln Gln Glu Ala Val Pro Thr Pro Arg 50 55 60 Arg Asp Ile Asn Pro Pro Ser Trp Pro Ala Ser Leu Ile Phe His Pro 65 70 75 80 Arg Pro Lys Pro Ile Ala Val Leu Pro Ala His Pro Asp Ser Phe Asp 85 90 95 Pro Asn Val Thr Leu Glu Gly Ala Gln Leu Ala Gly Gly Ala Trp Val 100 105 110 Arg Tyr Lys Ser Gly Asn Glu Val Arg Tyr Thr Ala Pro Ile Gln Leu 115 120 125 Ala Glu Glu Pro Thr Ser Arg Thr Pro Thr Ala Tyr Ala Leu Ala Gln 130 135 140 Glu Leu Gln Leu Ala Gly Gly Ala Thr Ala Thr Pro Pro Leu Met Gly 145 150 155 160 Glu Leu Ala Gly Ala Pro Arg Val Pro Arg Ser Gly Gly Ile Gly Ser 165 170 175 Trp Gln Phe Thr Gln Glu Phe Pro Pro Thr Val Tyr Leu Asn Pro Tyr 180 185 190 Ser Gly Ala Pro Asp Thr Phe Pro His Gln Phe Leu Ser Asn Tyr Asp 195 200 205 Ser Val Ser Gln Ser Val Asn Gly Tyr Asp 210 215 <210> 106 <211> 217 <212> PRT <213> Ovine adenovirus 7 <400> 106 Met Ala Gln Pro Val Thr Pro Tyr Val Trp Lys Tyr Gln Pro Glu Thr 1 5 10 15 Gly Tyr Thr Ala Gly Ala His Gln Asn Tyr Asn Thr Val Ile Asn Trp 20 25 30 Leu His Ala Asn Pro Gln Met Phe Ala Arg Ile Gln His Ile Asn Thr 35 40 45 Ala Arg Asn Val Met Asp Lys Phe Arg Ser Asp Leu Thr Arg Asp Asp 50 55 60 Ile Ala Val Asn Ile Asn Asn Trp Pro Ala Glu Asp Leu Met Gln Pro 65 70 75 80 Pro Asn Phe Pro Tyr Ile Pro Ala Thr Ser Lys Ser Ala Ser Thr Ile 85 90 95 Asn Asp Trp Leu Ala Thr Thr Gln Gly Ile Gln Leu Ser Gly Thr Ser 100 105 110 Glu Leu Asn Gly Trp Gly Ser Asn Arg Leu Thr Ser Tyr Pro Asp Ile 115 120 125 Pro Pro Ile Leu Lys Tyr Glu Arg Pro Gly Gln Gln Leu Gln Gly Gln 130 135 140 Gly Leu Phe Lys Gln Glu Asn Ile His Leu Phe Tyr Glu Ser Pro Arg 145 150 155 160 Leu Pro Arg Ser Gly Gly Leu Thr Pro Gln Gln Phe Val Lys Glu Phe 165 170 175 Pro Pro Val Val Tyr Asn Asn Pro Phe Ser Glu Ser Met Ser Val Phe 180 185 190 Pro Lys Glu Phe Ser Pro Leu Phe Asn Pro Ser Glu Ser Leu Lys Lys 195 200 205 Thr Ser Ser Gln Thr Leu Gln Tyr Lys 210 215 <210> 107 <211> 217 <212> PRT <213> Ovine adenovirus D <400> 107 Met Ala Gln Pro Val Thr Pro Tyr Val Trp Lys Tyr Gln Pro Glu Thr 1 5 10 15 Gly Tyr Thr Ala Gly Ala His Gln Asn Tyr Asn Thr Val Ile Asn Trp 20 25 30 Leu His Ala Asn Pro Gln Met Phe Ala Arg Ile Gln His Ile Asn Thr 35 40 45 Ala Arg Asn Val Met Asp Lys Phe Arg Ser Asp Leu Thr Arg Asp Asp 50 55 60 Ile Ala Val Asn Ile Asn Asn Trp Pro Ala Glu Asp Leu Met Gln Pro 65 70 75 80 Pro Asn Phe Pro Tyr Ile Pro Ala Thr Ser Lys Ser Ala Ser Thr Ile 85 90 95 Asn Asp Trp Leu Ala Thr Thr Gln Gly Ile Gln Leu Ser Gly Thr Ser 100 105 110 Glu Leu Asn Gly Trp Gly Ser Asn Arg Leu Thr Ser Tyr Pro Asp Ile 115 120 125 Pro Pro Ile Leu Lys Tyr Glu Arg Pro Gly Gln Gln Leu Gln Gly Gln 130 135 140 Gly Leu Phe Lys Gln Glu Asn Ile His Leu Phe Tyr Glu Ser Pro Arg 145 150 155 160 Leu Pro Arg Ser Gly Gly Leu Thr Pro Gln Gln Phe Val Lys Glu Phe 165 170 175 Pro Pro Val Val Tyr Asn Asn Pro Phe Ser Glu Ser Met Ser Val Phe 180 185 190 Pro Lys Glu Phe Ser Pro Leu Phe Asn Pro Ser Glu Ser Leu Lys Lys 195 200 205 Thr Ser Ser Gln Thr Leu Gln Tyr Lys 210 215 <210> 108 <211> 222 <212> PRT <213> Bovine adenovirus 4 <400> 108 Met Gln Pro Val Thr Pro Tyr Ile Trp Lys Tyr Gln Pro Glu Thr Gly 1 5 10 15 His Thr Ala Gly Ala His Gln Asp Tyr Gly Ser Val Ile Asn Trp Leu 20 25 30 Gln Ser Asn Pro Gln Met Phe Asn Arg Ile Arg Asp Ile Asn Leu Gln 35 40 45 Arg Asn Asn Ile Asp Gln Thr Gln Gly Leu Met Thr Arg Asp Asp Leu 50 55 60 His Ser Asn Ile Asn Asn Trp Pro Ala Ser Gln Val Leu Gln Arg Gln 65 70 75 80 Gly Phe Pro Tyr Val Pro Ala Lys Met Asn Leu Glu Ala Ser Lys Gln 85 90 95 Asp Phe Ile Asp Ser Ala Arg Gly Ile Gln Leu Ser Gly Pro Asn Pro 100 105 110 Val Phe Thr Gly Thr Gly Ser Asn Asn Leu Thr Ser Tyr Pro Met Leu 115 120 125 Thr Glu Asn Ile Pro Pro Leu Met Leu Tyr His Arg Pro Gly Gln Gln 130 135 140 Leu Gln Gly Met Gly Thr Ile Ser Lys Glu Asn Phe His Leu Leu Glu 145 150 155 160 Glu Val Ser Arg Val Pro Arg Ser Gly Gly Leu Thr Pro Thr Glu Phe 165 170 175 Leu Thr Gln Phe Pro Pro Ile Val Tyr Arg His Pro Phe Ser Ser Ser 180 185 190 Leu Ile Tyr Phe Pro Lys Glu Phe Asp Pro Leu Phe Ser Pro His Asn 195 200 205 Asp Pro Arg Leu Thr Ser Ser Lys Thr Leu Gln Tyr Val Pro 210 215 220 <210> 109 <211> 250 <212> PRT <213> Duck adenovirus 1 <400> 109 Met Gln Pro Val Thr Pro Tyr Leu Trp Arg Tyr Gln Pro Glu Thr Gly 1 5 10 15 Thr Ala Ala Gly Ala Arg Gln Asp Tyr Gly Ala Val Ile Asn Trp Phe 20 25 30 Asn Ser Gly Pro Asp Leu Tyr Arg Arg Ile Arg Asp Val Asn Ile Thr 35 40 45 Arg Asn Asn Val Glu Gln Thr Arg Ala Leu Ala Arg Thr Pro Leu Ser 50 55 60 Gly Asn Phe Asn Arg Trp Thr Ala Ala Gln Leu Thr His Pro Pro Gly 65 70 75 80 Thr Arg Tyr Lys Pro Tyr Phe Pro Val Asp Ser Ile Lys Gly Ala Arg 85 90 95 Asp Arg Val Ala Thr Gln Gln Gly Gln Ile Leu Ala Gly Ala Gly Tyr 100 105 110 Asp Leu His Asp Gly Arg Gln Tyr Arg Lys Ile Thr Arg Asp Ala Leu 115 120 125 Pro Phe Pro His Asn Trp Gln Val Lys Asp Gly Ser Arg Trp Val Asn 130 135 140 Leu Gly Gly Lys Gly Ala Asn Ser Leu Thr Thr Tyr Pro Val Ile Ala 145 150 155 160 Asp Ile Pro Pro Ile Met Arg Tyr Gly Arg Pro Gly Gln Gln Leu Gln 165 170 175 Gly Ser Gly Phe His Arg Pro Ser Pro Ala Leu Leu Thr Glu Glu Ala 180 185 190 Arg Val Pro Arg Ser His Gly Met Thr Val Arg Gln Phe Val His Glu 195 200 205 Phe Pro Pro Val Val Phe Asn His Pro Phe Ser Glu Asp Ile Thr Tyr 210 215 220 Phe Pro Lys Glu Phe Asn Pro Leu Phe Asn Pro Ser Glu Asp Tyr Arg 225 230 235 240 Val Ser Ser Asp Arg Thr Leu Gln Tyr Val 245 250 <210> 110 <211> 278 <212> PRT <213> Snake adenovirus <400> 110 Met Glu Ala Pro Val Thr Pro Tyr Ile Trp Gln Tyr Gln Pro Glu Thr 1 5 10 15 Gly Thr Ala Ala Gly Ala Arg Gln Asn Tyr Gly Ala Val Ile Asn Trp 20 25 30 Leu Ser Ser Asp Asn Asn Met Tyr His Arg Val Gln Glu Val Asn Arg 35 40 45 Gln Arg Asn Lys Ile Asp Asp Phe Arg Glu Gln Thr Val Arg Ala Asp 50 55 60 Met Ala His Ser Phe Asn Asp Trp Lys Pro Gln Gln Leu Ser Gln Pro 65 70 75 80 Ala Ser Thr Ala Tyr Leu Pro Ala Pro Asn Pro Ile Ala Gly Pro Arg 85 90 95 Thr Ile Pro Asp Val Ile Phe Thr Ala Glu Gly Glu Gln Leu Ala Gly 100 105 110 Ala Ser Pro Ser Leu Leu Ser Gly Gly Ala Ser Leu Pro Pro Ser Ser 115 120 125 Tyr Arg Leu Gly Asp Gly Arg Glu Tyr Arg Lys Phe Thr Arg Asp Ala 130 135 140 Met Pro Phe Pro His Asn Trp Leu Val Lys Glu Asn Gly Val Trp Val 145 150 155 160 Pro Val Glu Glu Arg Asp Pro Leu Leu Ser Glu Glu Gly Arg Asn Ala 165 170 175 Leu Ser Ser Tyr Pro Thr Leu Thr Tyr Ala Gln Pro Pro Ile Leu Arg 180 185 190 Tyr Arg Arg Leu Gly Gln Gln Leu Gln Gly Gly Gly Val Val Ala Pro 195 200 205 Ser Ser Arg Val Val Ser Leu Leu Thr Glu Gln Pro Arg Met Pro Arg 210 215 220 Thr Glu Gly Met Thr Pro Tyr Gln Phe Ser Ala Glu Phe Pro Pro Val 225 230 235 240 Val Tyr Asp His Pro Phe Ser Arg Asn Leu Thr Leu Phe Pro Lys Glu 245 250 255 Phe Ser Pro Leu Phe Asp Pro Lys Asp Gln Val Leu Ala Thr Ser Leu 260 265 270 Ala Thr Leu Gln Tyr Arg 275 <210> 111 <211> 246 <212> PRT <213> Fowl adenovirus 10 <400> 111 Met Asn Leu Leu Asn Ala Ala Pro Thr Pro Tyr Val Trp Lys Tyr Asn 1 5 10 15 Pro Val Thr Gly Lys Cys Ala Gly Ala Asn Arg Thr Thr Ala His Tyr 20 25 30 Arg Leu Val Leu Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp Glu 35 40 45 Ile Arg Arg Arg Phe Pro Glu Pro Ala Val Thr Arg Ala Ile Thr Ala 50 55 60 Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Tyr Ala Gly Pro His Glu 65 70 75 80 Thr Asn Ile Ile Thr Ala Asp Val Val Arg Ser Gly Pro Pro Pro Ser 85 90 95 Ala Val Tyr Pro Phe Asp Pro Ser Gly Val Gln Arg Val Gln Leu Ser 100 105 110 Gly Gly Met Met Gly Gly Arg Thr Glu Gly Arg Val Gln Leu Ser Gly 115 120 125 Gly Leu Thr Glu Gly Arg Met Gln Leu Ala Gly Gly Ala Ala Gly Lys 130 135 140 Leu Pro Thr Arg Ala Arg Pro Thr Leu Arg Pro Pro Arg Trp Cys Gly 145 150 155 160 Thr Thr Leu Thr Gly Asn Gly Leu Pro Ala Asp Tyr Pro Glu Met Thr 165 170 175 Pro Asp Ala Phe Lys Tyr Tyr Leu Arg Val Gln Gly Pro Ser Gln Glu 180 185 190 Val Asp Glu Pro Gly Val Met Ser Gln Arg Gln Phe Met Thr Thr Phe 195 200 205 Leu Pro Ala Met Val Pro His Pro Phe Asp Ser Glu Ser Pro Asp Ala 210 215 220 Phe Pro Ala Tyr Phe Ser Ser Val Tyr Lys Gly Thr Asn Gly Phe Glu 225 230 235 240 Pro Val Phe Trp Gln Gly 245 <210> 112 <211> 244 <212> PRT <213> Fowl adenovirus 8 <400> 112 Met Asn Leu Leu Glu Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn 1 5 10 15 Pro Leu Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr 20 25 30 Ile Asn Trp Val Val Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp 35 40 45 Glu Ile Arg Arg His Thr Leu Ser Pro Ala Ala Thr Arg Ala Ile Thr 50 55 60 Glu Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Phe Ala Asn Ala Arg 65 70 75 80 Glu Thr Ala Tyr Ile Thr Ala Asn Val Leu Asp Ser Gly Phe Pro Lys 85 90 95 Ser Ala Val Tyr Pro Val Asp Pro Ser Gly Val Gln Arg Val Gln Leu 100 105 110 Ser Gly Gly Ala Glu Gly Arg Met Gln Leu Ala Gly Gly Leu Thr Glu 115 120 125 Gly Arg Val Gln Leu Ser Gly Gly Val Leu Gly His Val Val Pro Pro 130 135 140 Gly Gly Arg Arg Arg Ala Gly Gly Arg Pro Pro Arg Trp Cys Gly Thr 145 150 155 160 Ala Leu Ala Gly Asn Gly Leu Pro Glu Asp Ala Glu Val Val Ser Asp 165 170 175 Thr Tyr Lys Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val Gln 180 185 190 Glu Pro Gly Val Tyr Ser Arg Arg Gln Phe Met Thr Thr Phe Leu Pro 195 200 205 Ala Val Val Pro Arg Pro Phe Ser Ser Pro Asn Pro Arg Asp Phe Pro 210 215 220 Ala Gln Tyr Ser Ala Ile Tyr Lys Gly Thr Asn Ala Tyr Glu Asp Val 225 230 235 240 Phe Trp Asp Trp <210> 113 <211> 241 <212> PRT <213> Fowl adenovirus 9 <400> 113 Met Asn Leu Leu Asp Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn 1 5 10 15 Pro Leu Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr 20 25 30 Ile Asn Trp Val Val Pro Gly Gly Asn Ser Phe Ala Tyr Ala Ala Asp 35 40 45 Glu Ile Arg Arg Asn Thr Leu Ser Pro Ala Val Thr Arg Ala Ile Thr 50 55 60 Ala Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Phe Ala Asn Pro Arg 65 70 75 80 Glu Thr Ala Tyr Ile Thr Ala Asn Val Leu Asp Ser Gly Phe Pro Lys 85 90 95 Ser Ala Val Tyr Pro Val Asp Pro Ser Gly Val Gln Lys Val Gln Leu 100 105 110 Ala Gly Gly Ala Glu Gly Arg Met Gln Leu Ser Gly Gly Leu Thr Glu 115 120 125 Gly Arg Val Gln Leu Ser Gly Gly Val Leu Gly His Val Pro Arg Arg 130 135 140 Ser Arg Arg Gly Ala Arg Pro Pro Arg Trp Cys Gly Thr Ala Leu Ala 145 150 155 160 Gly Asn Gly Leu Pro Glu Asp Ala Glu Met Val Ser Asp Thr Tyr Lys 165 170 175 Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val Ser Glu Pro Gly 180 185 190 Val Tyr Ser Gln Arg Gln Phe Met Thr Thr Phe Leu Pro Ala Val Val 195 200 205 Pro His Pro Phe Asp Ser Pro Asn Pro Asn Asp Phe Pro Ala Gln Tyr 210 215 220 Ser Ala Ile Tyr Lys Gly Thr Asn Ala Tyr Glu Asp Val Phe Trp Asp 225 230 235 240 Trp <210> 114 <211> 245 <212> PRT <213> Fowl adenovirus 1 <400> 114 Met Asn Leu Met Asn Ala Thr Pro Thr Glu Tyr Val Trp Lys Tyr Asn 1 5 10 15 Pro Val Ser Gly Ile Pro Ala Gly Ala Gln Gln Asn Tyr Gly Ala Thr 20 25 30 Ile Asp Trp Val Leu Pro Gly Gly Thr Gly Phe Ala Ile Ala Thr Asn 35 40 45 Asp Ile Arg Arg Gln Thr Leu Asn Pro Ala Val Thr Arg Ala Ile Thr 50 55 60 Ala Arg Phe Glu Ala Glu Ser Asp Gln Gln Pro Tyr Ala Ser Pro His 65 70 75 80 Glu Thr Asn Val Ile Ala Ala Asn Val Leu Asp Ser Gly Tyr Pro Lys 85 90 95 Ser Gly Leu Tyr Pro Leu Glu Leu Ser Gly Asn Gln Arg Val Gln Leu 100 105 110 Ala Gly Gly Leu Met Val Gly Arg Thr Glu Gly Arg Met Gln Leu Ala 115 120 125 Gly Gly Leu Thr Glu Gly Arg Val Gln Leu Ser Gly Gly Phe His Gly 130 135 140 Arg Pro Leu Val Arg Gly Arg Ser Arg Arg Pro Pro Arg Trp Cys Gly 145 150 155 160 Ala Glu Leu Thr Gly Asn Gly Leu Pro Glu Gln Ala Glu Val Thr Ser 165 170 175 Asp Thr Tyr Lys Tyr Phe Leu Arg Thr Gln Gly Pro Ser Gln Val Val 180 185 190 Glu Glu Pro Gly Val Phe Ser Gln Arg Gln Phe Met Thr Thr Phe Leu 195 200 205 Pro Ser Val Val Pro His Pro Phe Asp Ser Thr Asn Pro Gly Asp Phe 210 215 220 Pro Ala Gln Tyr Ser Ala Ile Tyr Lys Gly Arg Thr Ala Phe Glu Asp 225 230 235 240 Thr Phe Trp Asp Trp 245 <210> 115 <211> 200 <212> PRT <213> Turkey adenovirus 3 <400> 115 Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr 1 5 10 15 Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val 20 25 30 Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys 35 40 45 Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly 50 55 60 Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn 65 70 75 80 Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln 85 90 95 Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu 100 105 110 Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys 115 120 125 Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly 130 135 140 Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn 145 150 155 160 Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu 165 170 175 Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly 180 185 190 Gln Asn Pro Val Leu Asp Lys Ala 195 200 <210> 116 <211> 200 <212> PRT <213> Avirulent turkey hemorrhagic enteritis virus <400> 116 Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr 1 5 10 15 Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val 20 25 30 Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys 35 40 45 Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly 50 55 60 Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn 65 70 75 80 Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln 85 90 95 Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu 100 105 110 Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys 115 120 125 Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly 130 135 140 Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn 145 150 155 160 Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu 165 170 175 Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly 180 185 190 Gln Asn Pro Val Leu Asp Lys Ala 195 200 <210> 117 <211> 200 <212> PRT <213> Turkey adenovirus A <400> 117 Met Asp Pro Val Pro Leu Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr 1 5 10 15 Gly Arg Val Gly Gly Ala Asn Gln Asn Tyr Gly Gln Arg Ile Asn Val 20 25 30 Leu His Thr Asn Arg Tyr Leu Tyr Asn Arg Met Gln Asn Val Gln Lys 35 40 45 Lys Ser Asn Glu Arg Ala Thr Glu Arg Gly Leu Leu Ser Leu Lys Gly 50 55 60 Gly Ser Thr Leu Pro Thr Ile Ala Glu Asp Glu Pro Ala Gln Leu Asn 65 70 75 80 Ser Ala Ile Val Arg Met Ala Gly Leu Asn Asp Leu Asn Thr Val Gln 85 90 95 Ala Pro Asp Ser Ser Asn Leu Gln Asn Leu Ala Asn Ile Ala Leu Glu 100 105 110 Ala Ala Glu His Asn Lys Ala Thr Ser Ser Leu Leu Thr Thr Lys Lys 115 120 125 Phe Val Glu Glu Phe Pro Pro Val Val Tyr Glu Asn Pro Phe Ser Gly 130 135 140 Ser Asn Phe Ala Tyr Glu Phe Asn Pro Leu Tyr Ser Pro Ser Gly Asn 145 150 155 160 Glu Phe Ser Asn Pro Pro Phe Lys Phe Thr Gly Gly Ala Ile Ser Leu 165 170 175 Thr Gly Gln His Pro Val Leu Ser Gly Gly Ala Val Ile Leu Ser Gly 180 185 190 Gln Asn Pro Val Leu Asp Lys Ala 195 200 <210> 118 <211> 193 <212> PRT <213> Frog adenovirus 1 <400> 118 Met Glu Ala Glu Pro Ser Glu Tyr Ile Trp Gln Tyr Asn Pro Val Thr 1 5 10 15 Gly Arg Val Val Gly Ala Ser Gln Asn Phe Gly Ala Arg Ile Asn Thr 20 25 30 Leu His Ala Ser Pro Gln Leu Trp Ala Arg Met Gln Gln Val Gln Arg 35 40 45 Arg Arg Asn Glu Thr Val Thr Leu Ser Ala Leu Gln Gly Ser Gly Leu 50 55 60 Val Pro Ala Thr Pro Ser Ala Phe Gln Thr Thr Asp Ser Ser Asn Cys 65 70 75 80 Phe Leu Gly Gly Ser Asp Asn Trp Lys Glu Leu Leu Glu Pro Val Pro 85 90 95 Glu Ser Glu Glu Asn Pro Asn Gln Ala Leu Gln Asp Leu Leu Leu Ala 100 105 110 Ala Glu Ser Glu Lys Asp Gln Arg Asn Arg Asn Leu Thr Gln Ser Gln 115 120 125 Phe Val Ser Asp Phe Pro Pro Val Val Tyr Glu Arg Pro Phe Thr Gly 130 135 140 Ser Asp Phe Pro Leu Glu Phe Ser Pro Leu Tyr Ser Pro Asp Gly Asn 145 150 155 160 Gln Phe Thr Asn Thr Gly Trp Ile Ser Gln Ser Phe Pro Pro Asn Gln 165 170 175 Ser Phe Pro Glu Ile Ile Asn His Pro Thr Gln His Ser Ser Thr Thr 180 185 190 Ile <210> 119 <211> 221 <212> PRT <213> Porcine adenovirus 4 <400> 119 Met Pro Leu Ala Lys Glu Ile Pro Thr Pro Tyr Val Trp Ser Tyr Gln 1 5 10 15 Pro Gln Met Gly Val Pro Ala Gly Ala Ser Gln Asp Tyr Ser Thr Lys 20 25 30 Ile Asn Cys Leu Ser Ala Gly Pro Arg Met Ala Gln Thr Val Phe Ala 35 40 45 Leu Arg Asp Gln Arg Asn Arg Val Leu Thr Ala Glu Ala His Gly Gln 50 55 60 Thr Pro Arg Pro Val Val Asn Pro Ala Ser Trp Pro Ala Ala Ala Leu 65 70 75 80 Ser His Glu Pro Pro Pro Pro Thr Leu Leu Thr Leu Pro Arg Asn Glu 85 90 95 Pro Thr Glu His Ala Met Thr Asp Ala Gly Tyr Gln Ile Ala Gly Gly 100 105 110 Ala Ala Pro Trp Ser Gly Val Lys Thr Gly Ser Phe Cys Gly Arg Gly 115 120 125 Leu Gln Leu Ala Glu Pro Pro Thr Thr Ala Ile Tyr Pro Ser Gly Leu 130 135 140 Phe His Leu Gly Arg Gly Gln Arg Leu Val Leu Asp His Gln Pro Ala 145 150 155 160 Arg Thr Leu Leu Leu Glu Ser Ala Pro Ser Val Pro Arg Tyr Gly Gly 165 170 175 Ile Gly Ala Arg Gln Phe Leu Lys Glu Phe Thr Pro Ala Val Tyr Pro 180 185 190 Gln Pro Tyr Ser Gly Pro Pro Asn Thr Phe Pro Asp Tyr Phe Cys Phe 195 200 205 Asn Tyr Asp Ser Val Ser Asn Ser Val Asp Gly Tyr Ser 210 215 220 <210> 120 <211> 198 <212> PRT <213> Bovine adenovirus 10 <400> 120 Met Ser Lys Glu Ile Pro Thr Pro Tyr Val Trp Asn Tyr Gln Pro Gln 1 5 10 15 Ala Gly Thr Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Leu His 20 25 30 Trp Leu Ser Ala Gly Lys Ser Met Ile Ser Lys Val Asn Thr Ile Cys 35 40 45 Glu Asn Arg Asn Ser Ile Leu Leu Ser Lys Gly Met Gln Gln Leu Ala 50 55 60 Arg Leu Asn Ala Asn Pro Pro Phe Thr Asn Arg Ser Gln Ser Val Thr 65 70 75 80 Ala Leu Lys Leu Pro Arg Tyr Glu Ile Leu Glu Gln Arg Met Ser Asn 85 90 95 Ser Gly Met Gln Leu Ala Gly Gly Ser Leu Ser Leu Ala Glu Pro Leu 100 105 110 Cys Lys Gln Pro Leu Ala Pro Asp Gly Ser Phe Gln Leu Gly Gly Gly 115 120 125 Ala Lys Val Phe Ser Arg Gly Ala Thr Asn Tyr Ala Ile Arg Lys Thr 130 135 140 Ile Leu Leu Leu Glu Tyr Ser Gly Gly Met Gly Glu Lys Gln Phe Val 145 150 155 160 Lys Glu Phe Val Pro Ala Val Tyr Phe Asn Pro Tyr Ser Gly Leu Pro 165 170 175 Ala Ser Tyr Pro Asp Gln Phe Ile Ser Asn Tyr Asp Ala Val Thr Asp 180 185 190 Ser Val Asp Gly Tyr Ala 195 <210> 121 <211> 216 <212> PRT <213> Bovine adenovirus 3 <400> 121 Met Ser Lys Glu Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln 1 5 10 15 Met Gly Ala Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Phe Ser Ala Gly Pro Asp Met Ile His Asp Val Asn Asn Ile Arg 35 40 45 Asp Ala Gln Asn Arg Ile Leu Met Thr Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg Asn Leu Ile Asp Pro Arg Gln Trp Ala Ala His Leu Ile Lys 65 70 75 80 Gln Pro Val Val Gly Thr Thr His Val Glu Met Pro Arg Asn Glu Val 85 90 95 Leu Glu Gln His Leu Thr Ser His Gly Ala Gln Ile Ala Gly Gly Gly 100 105 110 Ala Ala Gly Asp Tyr Phe Lys Ser Pro Thr Ser Ala Arg Thr Leu Ile 115 120 125 Pro Leu Thr Ala Ser Cys Leu Arg Pro Asp Gly Val Phe Gln Leu Gly 130 135 140 Gly Gly Ser Arg Ser Ser Phe Asn Pro Leu Gln Thr Asp Phe Ala Phe 145 150 155 160 His Ala Leu Pro Ser Arg Pro Arg His Gly Gly Ile Gly Ser Arg Gln 165 170 175 Phe Val Glu Glu Phe Val Pro Ala Val Tyr Leu Asn Pro Tyr Ser Gly 180 185 190 Pro Pro Asp Ser Tyr Pro Asp Gln Phe Ile Arg His Tyr Asn Val Tyr 195 200 205 Ser Asn Ser Val Ser Gly Tyr Ser 210 215 <210> 122 <211> 227 <212> PRT <213> Tree shrew adenovirus <400> 122 Met Ser Lys Asp Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln 1 5 10 15 Met Gly Val Ala Ala Gly Ala Ser Gln Asp Tyr Gly Thr Lys Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ser Met Ile His Arg Val Asn Asn Ile Arg 35 40 45 Glu Ala Arg Asn Arg Ile Leu Leu Arg Gln Ala Ala Leu Thr Glu Thr 50 55 60 Pro Arg Ala Val Met Asn Pro Pro Asn Trp Pro Ser Thr Leu Leu Tyr 65 70 75 80 His Asp Val Ala Pro Pro Thr Ser Val Pro Leu Pro Arg Asn Glu Arg 85 90 95 Leu Glu Ile Ala Met Thr Asn His Gly Ala Gln Leu Ala Gly Gly Gly 100 105 110 His Thr Ser Leu Pro Glu Gly Leu Lys Arg Glu Leu Leu Phe Gly Ser 115 120 125 Gly Ile Gln Leu Asn Glu Gln Leu Pro Val Arg Pro Tyr Gly Ala Ala 130 135 140 Val Arg Ala Asp Gly Thr Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser 145 150 155 160 Phe Asn Pro Arg Glu Glu Leu Phe Leu Lys Leu Gln Ser Ala Pro Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Ser Trp Gln Phe Val Glu Glu Phe 180 185 190 Val Pro Ala Val Tyr Tyr Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr 195 200 205 Pro Asp Gln Phe Ile Ser Asn Tyr Asp Val Val Ser Asp Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 123 <211> 221 <212> PRT <213> Bovine adenovirus 1 <400> 123 Met Ser Lys Asp Ile Pro Thr Pro Tyr Val Trp Thr Phe Gln Pro Gln 1 5 10 15 Leu Gly Gly Cys Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn Trp 20 25 30 Leu Ser Ala Gly Pro Ser Met Ile Asn Gln Val Asn Ser Val Arg Ala 35 40 45 Asp Arg Asn Arg Ile Leu Leu Arg Gln Ala Ala Val Ser Glu Thr Pro 50 55 60 Arg Leu Val Arg Asn Pro Pro Thr Trp Pro Ala Gln Tyr Leu Phe Gln 65 70 75 80 Pro Ile Gly Ala Pro Gln Thr Phe Glu Leu Pro Arg Asn Glu Ser Leu 85 90 95 Glu Val Ala Met Ser Asn Ser Gly Met Gln Leu Ala Gly Gly Gly Arg 100 105 110 Arg Thr Lys Asp Ile Lys Pro Glu Asp Ile Val Gly Arg Gly Leu Glu 115 120 125 Leu Asn Ser Asp Ile Pro Ser Ala Ser Phe Leu Arg Pro Asp Gly Val 130 135 140 Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser Phe Asn Pro Gly Leu Ser 145 150 155 160 Thr Leu Leu Thr Val Gln Pro Ala Ser Ser Leu Pro Arg Ser Gly Gly 165 170 175 Ile Gly Glu Val Gln Phe Val His Glu Phe Val Pro Ser Val Tyr Phe 180 185 190 Gln Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Glu Phe Ile Tyr 195 200 205 Asn Tyr Asp Ile Val Ser Asp Ser Val Asp Gly Tyr Asp 210 215 220 <210> 124 <211> 223 <212> PRT <213> Ovine adenovirus A <400> 124 Met Ser Lys Glu Ile Pro Thr Pro His Met Trp Thr Phe Gln Pro Gln 1 5 10 15 Leu Gly Gln Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ser Met Ile Ser Gln Val Asp Ser Ile Arg 35 40 45 Ala Glu Arg Asn Arg Ile Leu Leu His Gln Ala Ala Val Ser Ala Thr 50 55 60 Pro Arg Ala Ile Met Asn Pro Pro Ala Trp Pro Ala Ser Arg Leu Phe 65 70 75 80 Gln Pro Val Asp Thr Val Gln Thr Leu Glu Leu Pro Arg Asn Glu Leu 85 90 95 Leu Glu Thr Ala Met Thr Asn Ser Gly Met Gln Leu Ala Gly Gly Gly 100 105 110 Val His Arg Thr Lys Asp Ile Lys Pro Glu Asp Leu Val Gly Arg Gly 115 120 125 Ile Gln Leu Asn Ser Tyr Gln Pro Pro Thr Thr Arg Leu Lys Pro Glu 130 135 140 Arg Val Phe Gln Leu Ala Gly Gly Ser Arg Ser Ser Phe Asn Pro Ser 145 150 155 160 Ile Asn Thr Leu Leu Thr Leu Gln Pro Ala Ala Ser Val Pro Arg Ser 165 170 175 Gly Gly Ile Gly Glu Val Gln Phe Val His Glu Phe Val Pro Ser Val 180 185 190 Tyr Phe Gln Pro Phe Ser Gly Pro Pro Gly Ser Tyr Pro Asp Glu Phe 195 200 205 Ile Tyr Asn Phe Asp Val Ala Thr Asp Ser Ile Asp Gly Tyr Ala 210 215 220 <210> 125 <211> 224 <212> PRT <213> Canine adenovirus 2 <400> 125 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Thr Gly His Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Gln Met Asn 20 25 30 Trp Phe Ser Ala Gly Pro Ser Met Ile Ser Gln Val Tyr Gly Ile Arg 35 40 45 Asp Leu Arg Asn Lys Val Leu Ile Thr Gln Ala Glu Ile Thr Lys Thr 50 55 60 Pro Arg Thr Ile Met Asp Pro Pro Ile Trp Pro Ala Ala Met Leu Val 65 70 75 80 Gln Glu Ala Ala Pro Pro Lys Thr Val Thr Leu Pro Arg Asn His Thr 85 90 95 Leu Glu Gln Ala Met Thr Asn Ser Gly Ala Gln Leu Ala Gly Gly Arg 100 105 110 Gln Leu Cys Pro Ser Gln Ile Gly Ile Lys Ser Pro Val Leu Ala Gly 115 120 125 Thr Gly Ile Gln Leu Ser Glu Asp Ile Pro Ser Ala Ser Trp Ile Arg 130 135 140 Pro Asp Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Ser 145 150 155 160 Pro Thr Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Thr Pro Arg 165 170 175 Ala Gly Gly Val Gly Thr Tyr Gln Phe Val Arg Glu Phe Val Pro Glu 180 185 190 Val Tyr Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln 195 200 205 Phe Ile Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp 210 215 220 <210> 126 <211> 224 <212> PRT <213> Canine adenovirus 1 <400> 126 Met Ser Lys Glu Ile Pro Thr Pro Tyr Ile Trp Ser Tyr Gln Pro Gln 1 5 10 15 Thr Gly His Ala Ala Gly Ala Ser Gln Asp Tyr Ser Thr Gln Met Asn 20 25 30 Trp Phe Ser Ala Gly Pro Ser Met Ile Ser His Val Tyr Gly Ile Arg 35 40 45 Asp Leu Arg Asn Lys Val Leu Met Thr Gln Ala Gln Ile Thr Lys Thr 50 55 60 Pro Arg Thr Ile Met Asp Pro Pro Ile Trp Pro Ala Ser Met Leu Val 65 70 75 80 Gln Lys His Ala Thr Pro Lys Thr Ile Ala Leu Pro Arg Asn His Thr 85 90 95 Leu Glu Gln Ala Met Val Asn Cys Gly Ala Gln Leu Ala Gly Gly Arg 100 105 110 Gln Pro Ser Pro Ser His Ile Asp Ile Lys Asp Thr Met Leu Ala Gly 115 120 125 Thr Gly Ile Gln Leu Gly Glu Asp Ile Pro Ser Val Ser Trp Ile Arg 130 135 140 Pro Asp Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Ser 145 150 155 160 Pro Thr Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Thr Pro Arg 165 170 175 Thr Gly Gly Val Gly Ser Tyr Gln Phe Val Arg Glu Phe Val Pro Glu 180 185 190 Val Tyr Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln 195 200 205 Phe Ile Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp 210 215 220 <210> 127 <211> 222 <212> PRT <213> Bat adenovirus TJM <400> 127 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Phe Gln Pro Gln 1 5 10 15 Ser Gly His Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Gln Met Asn 20 25 30 Trp Phe Ser Ala Gly Pro Ser Met Ile Asn Gln Val Tyr Gln Ile Arg 35 40 45 Asp Leu Arg Asn Arg Ile Leu Thr Thr Gln Ala Gln Ile Thr Glu Thr 50 55 60 Pro Arg Glu Val Met Asn Pro Pro Val Trp Pro Ala Ala Thr Ile Val 65 70 75 80 Gln Glu Ala Pro Pro Pro Thr Thr Val Ala Leu Pro Arg Asn His Ala 85 90 95 Leu Glu Thr Ala Met Thr Asn Ser Gly Ile Gln Leu Ala Gly Gly Arg 100 105 110 Cys Leu Leu Pro Ala Ala Arg Ala Ala Cys Pro Ile Lys Gly Arg Gly 115 120 125 Leu Gln Leu Ser Glu Asp Ile Pro Ser Ala Ser Trp Ile Arg Pro Asp 130 135 140 Gly Ile Phe Gln Leu Gly Gly Gly Ser Arg Ser Ser Phe Asn Pro Thr 145 150 155 160 Gln Ala Phe Leu Thr Leu Gln Gln Ala Ser Ser Gln Pro Arg Ala Gly 165 170 175 Gly Ile Gly Thr Val Gln Phe Val Arg Glu Phe Val Pro Glu Val Tyr 180 185 190 Leu Asn Pro Phe Ser Gly Pro Pro Asp Thr Phe Pro Asp Gln Phe Ile 195 200 205 Pro Asn Tyr Asp Ile Val Thr Asn Ser Val Asp Gly Tyr Asp 210 215 220 <210> 128 <211> 223 <212> PRT <213> Porcine adenovirus 1 <400> 128 Met Ser Lys Gln Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Ser Gly Arg Ala Ala Gly Ala Ser Val Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ser Met Ile Gly Gln Val Asn Asp Ile Arg 35 40 45 His Thr Arg Asn Gln Ile Leu Ile Arg Gln Ala Leu Ile Thr Glu Thr 50 55 60 Pro Arg Pro Val Gln Asn Pro Pro Ser Trp Pro Ala Arg Leu Leu Pro 65 70 75 80 Gln Met Thr Gln Pro Pro Thr His Leu His Leu Pro Arg Asn Glu Ile 85 90 95 Leu Glu Gly Arg Leu Thr Asp Ala Gly Met Gln Leu Ala Gly Gly Gly 100 105 110 Ala Leu Ala Pro Arg Asp Leu Tyr Ala Leu Thr Leu Arg Gly Arg Gly 115 120 125 Ile Gln Leu Asn Glu Asp Leu Pro Phe Ser Ala Ser Thr Leu Arg Pro 130 135 140 Asp Gly Ile Phe Gln Leu Gly Gly Gly Gly Arg Ser Ser Phe Asn Pro 145 150 155 160 Thr Asp Ala Tyr Leu Thr Leu Gln Asn Ser Ser Ser Leu Pro Arg Ser 165 170 175 Gly Gly Ile Gly Ser Asp Gln Phe Val Arg Glu Phe Val Pro Thr Val 180 185 190 Tyr Ile Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Gln Phe 195 200 205 Ile Ala Asn Tyr Asn Ile Leu Thr Asp Ser Val Ala Gly Tyr Asp 210 215 220 <210> 129 <211> 223 <212> PRT <213> Porcine adenovirus 3 <400> 129 Met Ser Lys Gln Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Ser Gly Arg Ala Ala Gly Ala Ser Val Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ser Met Ile Gly Gln Val Asn Asp Ile Arg 35 40 45 His Thr Arg Asn Gln Ile Leu Ile Arg Gln Ala Leu Ile Thr Glu Thr 50 55 60 Pro Arg Pro Val Gln Asn Pro Pro Ser Trp Pro Ala Ser Leu Leu Pro 65 70 75 80 Gln Met Thr Gln Pro Pro Thr His Leu His Leu Pro Arg Asn Glu Ile 85 90 95 Leu Glu Gly Arg Leu Thr Asp Ala Gly Met Gln Leu Ala Gly Gly Gly 100 105 110 Ala Leu Ala Pro Arg Asp Leu Tyr Ala Leu Thr Leu Arg Gly Arg Gly 115 120 125 Ile Gln Leu Asn Glu Asp Leu Pro Leu Ser Ala Ser Thr Leu Arg Pro 130 135 140 Asp Gly Ile Phe Gln Leu Gly Gly Gly Gly Arg Ser Ser Phe Asn Pro 145 150 155 160 Thr Asp Ala Tyr Leu Thr Leu Gln Asn Ser Ser Ser Leu Pro Arg Ser 165 170 175 Gly Gly Ile Gly Ser Glu Gln Phe Val Arg Glu Phe Val Pro Thr Val 180 185 190 Tyr Ile Asn Pro Phe Ser Gly Pro Pro Gly Thr Tyr Pro Asp Gln Phe 195 200 205 Ile Ala Asn Tyr Asn Ile Leu Thr Asp Ser Val Ala Gly Tyr Asp 210 215 220 <210> 130 <211> 227 <212> PRT <213> Simian adenovirus 22 <400> 130 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 131 <211> 227 <212> PRT <213> Simian adenovirus 23 <400> 131 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 132 <211> 227 <212> PRT <213> Simian adenovirus 24 <400> 132 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 133 <211> 233 <212> PRT <213> Simian adenovirus 1 <400> 133 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Ser Lys Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ala Ala Ile Thr Ala Thr 50 55 60 Pro Arg Arg Gln Leu Asn Pro Pro Ser Trp Pro Ala Ala Gln Val Tyr 65 70 75 80 Gln Glu Asn Pro Arg Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Glu 85 90 95 Ala Glu Val Leu Met Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ser 100 105 110 Arg Tyr Ala Arg Tyr Arg Gly Arg Ala Ala Pro Tyr Ser Pro Gly Ser 115 120 125 Ile Lys Arg Val Ile Ile Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu 130 135 140 Thr Val Ser Ser Ser Thr Gly Leu Arg Pro Asp Gly Val Phe Gln Leu 145 150 155 160 Gly Gly Ala Gly Arg Ser Ser Phe Thr Thr Arg Gln Ala Tyr Leu Thr 165 170 175 Leu Gln Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu 180 185 190 Gln Phe Val Glu Glu Phe Val Pro Ser Val Tyr Phe Asn Pro Phe Ser 195 200 205 Gly Ser Pro Gly Arg Tyr Pro Asp Ala Phe Ile Pro Asn Phe Asp Ala 210 215 220 Val Ser Glu Ser Val Asp Gly Tyr Asp 225 230 <210> 134 <211> 233 <212> PRT <213> Simian adenovirus 7 <400> 134 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Ser Lys Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ala Ala Ile Thr Ala Thr 50 55 60 Pro Arg Arg Gln Leu Asn Pro Pro Ser Trp Pro Ala Ala Gln Val Tyr 65 70 75 80 Gln Glu Thr Pro Arg Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Glu 85 90 95 Ala Glu Val Leu Met Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ser 100 105 110 Arg Tyr Ala Arg Tyr Arg Gly Arg Ala Ala Pro Tyr Ser Pro Gly Ser 115 120 125 Ile Lys Arg Val Ile Ile Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu 130 135 140 Ala Val Ser Ser Ser Thr Gly Leu Arg Pro Asp Gly Val Phe Gln Leu 145 150 155 160 Gly Gly Ala Gly Arg Ser Ser Phe Thr Thr Arg Gln Ala Tyr Leu Thr 165 170 175 Leu Gln Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu 180 185 190 Gln Phe Val Glu Glu Phe Val Pro Ser Val Tyr Phe Asn Pro Phe Ser 195 200 205 Gly Ser Pro Gly Arg Tyr Pro Asp Ala Phe Ile Pro Asn Phe Asp Ala 210 215 220 Val Ser Glu Ser Val Asp Gly Tyr Asp 225 230 <210> 135 <211> 227 <212> PRT <213> Human adenovirus 5 <400> 135 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Ile Asn 20 25 30 Tyr Met Ser Ala Gly Pro His Met Ile Ser Arg Val Asn Gly Ile Arg 35 40 45 Ala His Arg Asn Arg Ile Leu Leu Glu Gln Ala Ala Ile Thr Thr Thr 50 55 60 Pro Arg Asn Asn Leu Asn Pro Arg Ser Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ser Pro Ala Pro Thr Thr Val Val Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Met Thr Asn Ser Gly Ala Gln Leu Ala Gly Gly Phe 100 105 110 Arg His Arg Val Arg Ser Pro Gly Gln Gly Ile Thr His Leu Thr Ile 115 120 125 Arg Gly Arg Gly Ile Gln Leu Asn Asp Glu Ser Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Thr Phe Gln Ile Gly Gly Ala Gly Arg Pro 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Ile Leu Thr Leu Gln Thr Ser Ser Ser 165 170 175 Glu Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Ile Glu Glu Phe 180 185 190 Val Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Pro Pro Gly His Tyr 195 200 205 Pro Asp Gln Phe Ile Pro Asn Phe Asp Ala Val Lys Asp Ser Ala Asp 210 215 220 Gly Tyr Asp 225 <210> 136 <211> 951 <212> PRT <213> Human adenovirus 5 <400> 136 Met Ala Thr Pro Ser Met Met Pro Gln Trp Ser Tyr Met His Ile Ser 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Glu Thr Tyr Phe Ser Leu Asn Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Ile Pro Val Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 65 70 75 80 Lys Ala Arg Phe Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Thr 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ala Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Pro Cys Glu Trp Asp Glu Ala Ala Thr Ala Leu Glu Ile 130 135 140 Asn Leu Glu Glu Glu Asp Asp Asp Asn Glu Asp Glu Val Asp Glu Gln 145 150 155 160 Ala Glu Gln Gln Lys Thr His Val Phe Gly Gln Ala Pro Tyr Ser Gly 165 170 175 Ile Asn Ile Thr Lys Glu Gly Ile Gln Ile Gly Val Glu Gly Gln Thr 180 185 190 Pro Lys Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Ile Gly Glu 195 200 205 Ser Gln Trp Tyr Glu Thr Glu Ile Asn His Ala Ala Gly Arg Val Leu 210 215 220 Lys Lys Thr Thr Pro Met Lys Pro Cys Tyr Gly Ser Tyr Ala Lys Pro 225 230 235 240 Thr Asn Glu Asn Gly Gly Gln Gly Ile Leu Val Lys Gln Gln Asn Gly 245 250 255 Lys Leu Glu Ser Gln Val Glu Met Gln Phe Phe Ser Thr Thr Glu Ala 260 265 270 Ala Ala Gly Asn Gly Asp Asn Leu Thr Pro Lys Val Val Leu Tyr Ser 275 280 285 Glu Asp Val Asp Ile Glu Thr Pro Asp Thr His Ile Ser Tyr Met Pro 290 295 300 Thr Ile Lys Glu Gly Asn Ser Arg Glu Leu Met Gly Gln Gln Ser Met 305 310 315 320 Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp Asn Phe Ile Gly Leu 325 330 335 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 340 345 350 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 355 360 365 Ser Tyr Gln Leu Leu Leu Asp Ser Ile Gly Asp Arg Thr Arg Tyr Phe 370 375 380 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile 385 390 395 400 Ile Glu Asn His Gly Thr Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro 405 410 415 Leu Gly Gly Val Ile Asn Thr Glu Thr Leu Thr Lys Val Lys Pro Lys 420 425 430 Thr Gly Gln Glu Asn Gly Trp Glu Lys Asp Ala Thr Glu Phe Ser Asp 435 440 445 Lys Asn Glu Ile Arg Val Gly Asn Asn Phe Ala Met Glu Ile Asn Leu 450 455 460 Asn Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ser Asn Ile Ala Leu Tyr 465 470 475 480 Pro Asp Lys Leu Lys Tyr Ser Pro Ser Asn Val Lys Ile Ser Asp Asn 485 490 495 Pro Asn Thr Tyr Asp Tyr Met Asn Lys Arg Val Val Ala Pro Gly Leu 500 505 510 Val Asp Cys Tyr Ile Asn Leu Gly Ala Arg Trp Ser Leu Asp Tyr Met 515 520 525 Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr 530 535 540 Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln 545 550 555 560 Val Pro Gln Lys Phe Phe Ala Ile Lys Asn Leu Leu Leu Leu Pro Gly 565 570 575 Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Val Leu 580 585 590 Gln Ser Ser Leu Gly Asn Asp Leu Arg Val Asp Gly Ala Ser Ile Lys 595 600 605 Phe Asp Ser Ile Cys Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn 610 615 620 Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln 625 630 635 640 Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro 645 650 655 Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala 660 665 670 Ala Phe Arg Gly Trp Ala Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro 675 680 685 Ser Leu Gly Ser Gly Tyr Asp Pro Tyr Tyr Thr Tyr Ser Gly Ser Ile 690 695 700 Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val 705 710 715 720 Ala Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu 725 730 735 Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Ser Val Asp Gly Glu Gly 740 745 750 Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln 755 760 765 Met Leu Ala Asn Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Ile Pro Glu 770 775 780 Ser Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met 785 790 795 800 Ser Arg Gln Val Val Asp Asp Thr Lys Tyr Lys Asp Tyr Gln Gln Val 805 810 815 Gly Ile Leu His Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala 820 825 830 Pro Thr Met Arg Glu Gly Gln Ala Tyr Pro Ala Asn Phe Pro Tyr Pro 835 840 845 Leu Ile Gly Lys Thr Ala Val Asp Ser Ile Thr Gln Lys Lys Phe Leu 850 855 860 Cys Asp Arg Thr Leu Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser 865 870 875 880 Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Leu Leu Tyr Ala Asn Ser 885 890 895 Ala His Ala Leu Asp Met Thr Phe Glu Val Asp Pro Met Asp Glu Pro 900 905 910 Thr Leu Leu Tyr Val Leu Phe Glu Val Phe Asp Val Val Arg Val His 915 920 925 Gln Pro His Arg Gly Val Ile Glu Thr Val Tyr Leu Arg Thr Pro Phe 930 935 940 Ser Ala Gly Asn Ala Thr Thr 945 950 <210> 137 <211> 35938 <212> DNA <213> Human adenovirus 5 <400> 137 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720 ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840 actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020 atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt 4080 cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt 4140 cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat 4200 acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg 4260 gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt 4320 ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt 4380 taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt 4440 tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag 4500 tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact 4560 tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg 4620 gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt 4680 ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg 4740 gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg 4800 ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg 4860 gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc 4920 cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc 4980 tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt 5040 ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag 5100 caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa 5160 gcagttccag gcggtcccac agctcggtca cctgctctac ggcatctcga tccagcatat 5220 ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag 5280 acgggccagg gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac 5340 ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct 5400 ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt 5460 gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc 5520 gccgcacgag gggcagtgca gacttttgag ggcgtagagc ttgggcgcga gaaataccga 5580 ttccggggag taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca 5640 ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt 5700 cttacctctg gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc 5760 cccgtataca gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag 5820 aaactcggac cactctgaga caaaggctcg cgtccaggcc agcacgaagg aggctaagtg 5880 ggaggggtag cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat 5940 gtcgccctct tcggcatcaa ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg 6000 tgttcctgaa ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc 6060 atcgctgtct gcgagggcca gctgttgggg tgagtactcc ctctgaaaag cgggcatgac 6120 ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc 6180 ggtgatgcct ttgagggtgg ccgcatccat ctggtcagaa aagacaatct ttttgttgtc 6240 aagcttggtg gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag 6300 ggtttggttt ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc 6360 gcgcgcaacg caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac 6420 gcgccaaccg cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag 6480 gcgctcgttg gtccagcaga ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc 6540 tagctgcgtc tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc 6600 gtcgaagtag tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc 6660 aagcgcgcgc tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga 6720 ggcgtacatg ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt 6780 agggtagcat cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg 6840 agcgaggagg tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg 6900 cctgaagatg gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc 6960 gtctgtgaga cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac 7020 cagctcggcg gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc 7080 atacttatcc tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc 7140 tttccagtac tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta 7200 gaactggttg acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg 7260 cgcggccttc cggagcgagg tgtgggtgag cgcaaaggtg tccctgacca tgactttgag 7320 gtactggtat ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt 7380 gcgctttttg gaacgcggat ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc 7440 cgcgcgaggc ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt 7500 aattacctgg gcggcgagca cgatctcgtc aaagccgttg atgttgtggc ccacaatgta 7560 aagttccaag aagcgcggga tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt 7620 gagctcttca ggggagctga gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt 7680 ggaagcgacg aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa 7740 ggtcctaaac tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg 7800 gtcttgttcc cagcggtccc atccaaggtt cgcggctagg tctcgcgcgg cagtcactag 7860 aggctcatct ccgccgaact tcatgaccag catgaagggc acgagctgct tcccaaaggc 7920 ccccatccaa gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg 7980 cgagccgatc gggaagaact ggatctcccg ccaccaattg gaggagtggc tattgatgtg 8040 gtgaaagtag aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc 8100 gcagtactgg cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg 8160 cacaaggaag cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc 8220 tacttcggct gcttgtcctt gaccgtctgg ctgctcgagg ggagttacgg tggatcggac 8280 caccacgccg cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac 8340 aacatcgcgc agatgggagc tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg 8400 gagctcctgc aggtttacct cgcatagacg ggtcagggcg cgggctagat ccaggtgata 8460 cctaatttcc aggggctggt tggtggcggc gtcgatggct tgcaagaggc cgcatccccg 8520 cggcgcgact acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc 8580 atctaaaagc ggtgacgcgg gcgagccccc ggaggtaggg ggggctccgg acccgccggg 8640 agagggggca ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg 8700 ttgctggcga acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag 8760 acgacgggcc cggtgagctt gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg 8820 ttgacggcgg cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatc 8880 tcggccatga actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg 8940 gtggcggcga ggtcgttgga aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc 9000 tcgttccaga cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc 9060 tgcgcgagat tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag 9120 aggtagttga gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc 9180 aacgtggatt cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc 9240 acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga 9300 cggatgagct cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct 9360 tcttcttcaa tctcctcttc cataagggcc tccccttctt cttcttctgg cggcggtggg 9420 ggagggggga cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc 9480 atctccccgc ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc 9540 agttggaaga cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccatgcggc 9600 agggatacgg cgctaacgat gcatctcaac aattgttgtg taggtactcc gccgccgagg 9660 gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag 9720 tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg 9780 tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg 9840 gtcgacagaa gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg 9900 ccccaggctt cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct 9960 accggcactt cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg 10020 gcggcggagt ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc 10080 ctcatcggct gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc 10140 acctgcgtga gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg 10200 ttgatggtgt aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc 10260 gagagctcgg tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa 10320 gtccgcacca ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc 10380 cagcgtaggg tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg 10440 tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg 10500 cggacgcggt tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg 10560 ccggtcaggc gcgcgcaatc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg 10620 ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt 10680 tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc 10740 caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg 10800 gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa 10860 gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc 10920 gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc 10980 ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc 11040 ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag 11100 caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg 11160 acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg 11220 cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag 11280 cggtacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac 11340 ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca 11400 gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag 11460 cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta 11520 accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac 11580 gtgcgtacgc ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt 11640 gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata 11700 gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc 11760 gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc 11820 agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag 11880 ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc 11940 gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt 12000 tatcgcaacg agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac 12060 cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag 12120 gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg 12180 gaggcagctg gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc 12240 ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg 12300 gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc 12360 agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca 12420 tgtcgctgac tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct 12480 ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg 12540 cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct 12600 acgacgcgct gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg 12660 accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg 12720 gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc 12780 cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga 12840 caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag 12900 gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc 12960 gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt 13020 tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag 13080 gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt 13140 tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg 13200 caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa 13260 acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc 13320 gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca 13380 tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg 13440 ccgtgaaccc cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg 13500 gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca 13560 tagacgacag cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc 13620 aggcagaggc ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag 13680 gcgctgcggc cccgcggtca gatgctagta gcccatttcc aagcttgata gggtctctta 13740 ccagcactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc 13800 tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga 13860 gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcacagg gacgtgccag 13920 gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg 13980 acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg 14040 cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata 14100 aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg 14160 gcgcgcggcg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc 14220 gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc 14280 tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agttggcacc 14340 cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct 14400 gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag 14460 cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga 14520 cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa 14580 gtttaaggcg cgggtgatgg tgtcgcgctt gcctactaag gacaatcagg tggagctgaa 14640 atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga 14700 ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct 14760 ggaaagcgac atcggggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt 14820 cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt 14880 gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg 14940 caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa 15000 cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca 15060 gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa 15120 cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga 15180 cacctttgcc acacgggctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc 15240 cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct 15300 gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca 15360 gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg 15420 gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtcgttgcc 15480 agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt 15540 ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta 15600 ctcccaactc atccgccagt ttacctctct gacccacgtg ttcaatcgct ttcccgagaa 15660 ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc 15720 tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac 15780 cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc 15840 gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag 15900 caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg 15960 ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa 16020 acgcggccgc actgggcgca ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc 16080 gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt 16140 ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg 16200 ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc 16260 acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt 16320 cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc 16380 tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg 16440 cgtgcccgtg cgcacccgcc ccccgcgcaa ctagattgca agaaaaaact acttagactc 16500 gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat 16560 caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga 16620 gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga 16680 tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg 16740 gaaaggtcga cgcgtaaaac gtgttttgcg acccggcacc accgtagtct ttacgcccgg 16800 tgagcgctcc acccgcacct acaagcgcgt gtatgatgag gtgtacggcg acgaggacct 16860 gcttgagcag gccaacgagc gcctcgggga gtttgcctac ggaaagcggc ataaggacat 16920 gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca 16980 gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg 17040 tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt 17100 ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca 17160 ggtggcgccg ggactgggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac 17220 cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt 17280 ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca 17340 aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta 17400 cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc 17460 cggctatcgt ggctacacct accgccccag aagacgagca actacccgac gccgaaccac 17520 cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg 17580 cagggtggct cgcgaaggag gcaggaccct ggtgctgcca acagcgcgct accaccccag 17640 catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg 17700 tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg 17760 cctgacgggc ggcatgcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat 17820 gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc 17880 cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg 17940 gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta 18000 gaatggaaga catcaacttt gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg 18060 gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc 18120 tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga 18180 acagcagcac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg 18240 tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc 18300 aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg 18360 tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa 18420 ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caaggcctgc 18480 ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa 18540 cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg 18600 ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat 18660 cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg 18720 gggtgcaatc cctgaagcgc cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc 18780 atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa 18840 gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc 18900 ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag 18960 cctgaataac aagtttagaa accccacggt ggcgcctacg cacgacgtga ccacagaccg 19020 gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta 19080 caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg ctggacatgg cttccacgta 19140 ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc 19200 ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac 19260 tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca 19320 agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac 19380 aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt 19440 tcaacctgaa cctcaaatag gagaatctca gtggtacgaa actgaaatta atcatgcagc 19500 tgggagagtc cttaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc 19560 cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag 19620 tcaagtggaa atgcaatttt tctcaactac tgaggcgacc gcaggcaatg gtgataactt 19680 gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat 19740 ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat 19800 gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa 19860 cagcacgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga 19920 tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag 19980 aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat 20040 tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt 20100 gattaataca gagactctta ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga 20160 aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat 20220 ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta 20280 tttgcccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac 20340 ctacgactac atgaacaagc gagtggtggc tcccgggtta gtggactgct acattaacct 20400 tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa 20460 tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat 20520 ccaggtgcct cagaagttct ttgccattaa aaacctcctt ctcctgccgg gctcatacac 20580 ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga 20640 cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt 20700 ccccatggcc cacaacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga 20760 ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc 20820 taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt 20880 cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac 20940 ctactctggc tctataccct acctagatgg aaccttttac ctcaaccaca cctttaagaa 21000 ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc 21060 caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa 21120 catgaccaaa gactggttcc tggtacaaat gctagctaac tacaacattg gctaccaggg 21180 cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc 21240 catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct 21300 acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca 21360 ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac 21420 ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat 21480 gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc 21540 gctagacatg acttttgagg tggatcccat ggacgagccc acccttcttt atgttttgtt 21600 tgaagtcttt gacgtggtcc gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta 21660 cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca 21720 acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt 21780 tgtgggccat attttttggg cacctatgac aagcgctttc caggctttgt ttctccacac 21840 aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctgggggcgt acactggatg 21900 gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct 21960 gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc 22020 attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg 22080 cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg 22140 ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc 22200 atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc 22260 ttcctggagc gccactcgcc ctacttccgc agccacagtg cgcagattag gagcgccact 22320 tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc 22380 aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc 22440 gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg 22500 cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg 22560 aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat 22620 atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacagggttg 22680 cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag 22740 atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc 22800 tgccttccca aaaagggcgc gtgcccaggc tttgagttgc actcgcaccg tagtggcatc 22860 aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc 22920 tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg 22980 gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag 23040 atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc 23100 ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt caatcacgtg ctccttattt 23160 atcataatgc ttccgtgtag acacttaagc tcgccttcga tctcagcgca gcggtgcagc 23220 cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg 23280 tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc 23340 tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact 23400 tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc 23460 agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg 23520 ttcatcaccg taatttcact ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc 23580 ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg 23640 ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatcttct 23700 ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttgggagaa 23760 gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc 23820 gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg 23880 atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg 23940 gacgacacgt cctccatggt tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg 24000 gtttcgcgct gctcctcttc ccgactggcc atttccttct cctataggca gaaaaagatc 24060 atggagtcag tcgagaagaa ggacagccta accgccccct ctgagttcgc caccaccgcc 24120 tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag 24180 gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca 24240 gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc 24300 gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag 24360 catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgatgtgccc 24420 ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc 24480 cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta 24540 tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc 24600 ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct 24660 gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc 24720 gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct 24780 ggagtgttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc 24840 gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc 24900 atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa 24960 caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg 25020 cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc 25080 gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag 25140 gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac 25200 gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa 25260 aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt 25320 tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag 25380 gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa acttgaagga cctatggacg 25440 gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg 25500 cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt 25560 aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc 25620 gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt 25680 ctgcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac 25740 ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc 25800 aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg 25860 cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct 25920 taccttcgca aatttgtacc tgaggactac cacgcccacg agattaggtt ctacgaagac 25980 caatcccgcc cgccaaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt 26040 ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg 26100 gtttacttgg acccccagtc cggcgaggag ctcaacccaa tccccccgcc gccgcagccc 26160 tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct 26220 gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga 26280 cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt 26340 cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca 26400 gaaatcggca accggttcca gcatggctac aacctccgct cctcaggcgc cgccggcact 26460 gcccgttcgc cgacccaacc gtagatggga caccactgga accagggccg gtaagtccaa 26520 gcagccgccg ccgttagccc aagagcaaca acagcgccaa ggctaccgct catggcgcgg 26580 gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg 26640 ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg 26700 tcatctctac agcccatact gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca 26760 cacagaagca aaggcgaccg gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg 26820 cggcagcagc aggaggagga gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg 26880 agcttagaaa caggattttt cccactctgt atgctatatt tcaacagagc aggggccaag 26940 aacaagagct gaaaataaaa aacaggtctc tgcgatccct cacccgcagc tgcctgtatc 27000 acaaaagcga agatcagctt cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat 27060 actgcgcgct gactcttaag gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac 27120 tacgtcatct ccagcggcca cacccggcgc cagcacctgt cgtcagcgcc attatgagca 27180 aggaaattcc cacgccctac atgtggagtt accagccaca aatgggactt gcggctggag 27240 ctgcccaaga ctactcaacc cgaataaact acatgagcgc gggaccccac atgatatccc 27300 gggtcaacgg aatccgcgcc caccgaaacc gaattctctt ggaacaggcg gctattacca 27360 ccacacctcg taataacctt aatccccgta gttggcccgc tgccctggtg taccaggaaa 27420 gtcccgctcc caccactgtg gtacttccca gagacgccca ggccgaagtt cagatgacta 27480 actcaggggc gcagcttgcg ggcggctttc gtcacagggt gcggtcgccc gggcagggta 27540 taactcacct gacaatcaga gggcgaggta ttcagctcaa cgacgagtcg gtgagctcct 27600 cgcttggtct ccgtccggac gggacatttc agatcggcgg cgccggccgt ccttcattca 27660 cgcctcgtca ggcaatccta actctgcaga cctcgtcctc tgagccgcgc tctggaggca 27720 ttggaactct gcaatttatt gaggagtttg tgccatcggt ctactttaac cccttctcgg 27780 gacctcccgg ccactatccg gatcaattta ttcctaactt tgacgcggta aaggactcgg 27840 cggacggcta cgactgaatg ttaagtggag aggcagagca actgcgcctg aaacacctgg 27900 tccactgtcg ccgccacaag tgctttgccc gcgactccgg tgagttttgc tactttgaat 27960 tgcccgagga tcatatcgag ggcccggcgc acggcgtccg gcttaccgcc cagggagagc 28020 ttgcccgtag cctgattcgg gagtttaccc agcgccccct gctagttgag cgggacaggg 28080 gaccctgtgt tctcactgtg atttgcaact gtcctaacct tggattacat caagatcttt 28140 gttgccatct ctgtgctgag tataataaat acagaaatta aaatatactg gggctcctat 28200 cgccatcctg taaacgccac cgtcttcacc cgcccaagca aaccaaggcg aaccttacct 28260 ggtactttta acatctctcc ctctgtgatt tacaacagtt tcaacccaga cggagtgagt 28320 ctacgagaga acctctccga gctcagctac tccatcagaa aaaacaccac cctccttacc 28380 tgccgggaac gtacgagtgc gtcaccggcc gctgcaccac acctaccgcc tgaccgtaaa 28440 ccagactttt tccggacaga cctcaataac tctgtttacc agaacaggag gtgagcttag 28500 aaaaccctta gggtattagg ccaaaggcgc agctactgtg gggtttatga acaattcaag 28560 caactctacg ggctattcta attcaggttt ctctagaatc ggggttgggg ttattctctg 28620 tcttgtgatt ctctttattc ttatactaac gcttctctgc ctaaggctcg ccgcctgctg 28680 tgtgcacatt tgcatttatt gtcagctttt taaacgctgg ggtcgccacc caagatgatt 28740 aggtacataa tcctaggttt actcaccctt gcgtcagccc acggtaccac ccaaaaggtg 28800 gattttaagg agccagcctg taatgttaca ttcgcagctg aagctaatga gtgcaccact 28860 cttataaaat gcaccacaga acatgaaaag ctgcttattc gccacaaaaa caaaattggc 28920 aagtatgctg tttatgctat ttggcagcca ggtgacacta cagagtataa tgttacagtt 28980 ttccagggta aaagtcataa aacttttatg tatacttttc cattttatga aatgtgcgac 29040 attaccatgt acatgagcaa acagtataag ttgtggcccc cacaaaattg tgtggaaaac 29100 actggcactt tctgctgcac tgctatgcta attacagtgc tcgctttggt ctgtacccta 29160 ctctatatta aatacaaaag cagacgcagc tttattgagg aaaagaaaat gccttaattt 29220 actaagttac aaagctaatg tcaccactaa ctgctttact cgctgcttgc aaaacaaatt 29280 caaaaagtta gcattataat tagaatagga tttaaacccc ccggtcattt cctgctcaat 29340 accattcccc tgaacaattg actctatgtg ggatatgctc cagcgctaca accttgaagt 29400 caggcttcct ggatgtcagc atctgacttt ggccagcacc tgtcccgcgg atttgttcca 29460 gtccaactac agcgacccac cctaacagag atgaccaaca caaccaacgc ggccgccgct 29520 accggactta catctaccac aaatacaccc caagtttctg cctttgtcaa taactgggat 29580 aacttgggca tgtggtggtt ctccatagcg cttatgtttg tatgccttat tattatgtgg 29640 ctcatctgct gcctaaagcg caaacgcgcc cgaccaccca tctatagtcc catcattgtg 29700 ctacacccaa acaatgatgg aatccataga ttggacggac tgaaacacat gttcttttct 29760 cttacagtat gattaaatga gacatgattc ctcgagtttt tatattactg acccttgttg 29820 cgcttttttg tgcgtgctcc acattggctg cggtttctca catcgaagta gactgcattc 29880 cagccttcac agtctatttg ctttacggat ttgtcaccct cacgctcatc tgcagcctca 29940 tcactgtggt catcgccttt atccagtgca ttgactgggt ctgtgtgcgc tttgcatatc 30000 tcagacacca tccccagtac agggacagga ctatagctga gcttcttaga attctttaat 30060 tatgaaattt actgtgactt ttctgctgat tatttgcacc ctatctgcgt tttgttcccc 30120 gacctccaag cctcaaagac atatatcatg cagattcact cgtatatgga atattccaag 30180 ttgctacaat gaaaaaagcg atctttccga agcctggtta tatgcaatca tctctgttat 30240 ggtgttctgc agtaccatct tagccctagc tatatatccc taccttgaca ttggctggaa 30300 acgaatagat gccatgaacc acccaacttt ccccgcgccc gctatgcttc cactgcaaca 30360 agttgttgcc ggcggctttg tcccagccaa tcagcctcgc cccacttctc ccacccccac 30420 tgaaatcagc tactttaatc taacaggagg agatgactga caccctagat ctagaaatgg 30480 acggaattat tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc 30540 gcatgaatca agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt 30600 gtctggtaaa gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct 30660 acaagttgcc aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca 30720 taactcagca ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg 30780 atctctgcac ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat 30840 aaaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta 30900 ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca 30960 aactttctcc acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc 31020 actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc 31080 gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt 31140 gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa 31200 cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac 31260 gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc 31320 aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact 31380 gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc 31440 ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca 31500 gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt 31560 actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa 31620 gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta 31680 acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact 31740 tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt 31800 aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt 31860 tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata 31920 aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca 31980 aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct 32040 acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac 32100 acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg 32160 gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac 32220 aaaaataatg ataagctaac tttgtggacc acaccagctc catctcctaa ctgtagacta 32280 aatgcagaga aagatgctaa actcactttg gtcttaacaa aatgtggcag tcaaatactt 32340 gctacagttt cagttttggc tgttaaaggc agtttggctc caatatctgg aacagttcaa 32400 agtgctcatc ttattataag atttgacgaa aatggagtgc tactaaacaa ttccttcctg 32460 gacccagaat attggaactt tagaaatgga gatcttactg aaggcacagc ctatacaaac 32520 gctgttggat ttatgcctaa cctatcagct tatccaaaat ctcacggtaa aactgccaaa 32580 agtaacattg tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt aacactaacc 32640 attacactaa acggtacaca ggaaacagga gacacaactc caagtgcata ctctatgtca 32700 ttttcatggg actggtctgg ccacaactac attaatgaaa tatttgccac atcctcttac 32760 actttttcat acattgccca agaataaaga atcgtttgtg ttatgtttca acgtgtttat 32820 ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca 32880 tagcttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc 32940 acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat 33000 catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc 33060 caaacgctca tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct 33120 gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg 33180 agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg 33240 ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat 33300 ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg 33360 ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac 33420 aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac 33480 agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa 33540 cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca 33600 tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac 33660 ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca 33720 ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca 33780 cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg 33840 aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact 33900 cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt 33960 agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga 34020 caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt 34080 tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct 34140 tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc 34200 tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg 34260 cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag 34320 cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca 34380 aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc 34440 aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc 34500 ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt 34560 ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta 34620 agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc 34680 ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa 34740 gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca 34800 gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca 34860 tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag 34920 ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat 34980 caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc 35040 aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg 35100 gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct 35160 tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc 35220 gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg 35280 agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa 35340 gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc 35400 cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc 35460 ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc 35520 agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac 35580 acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat 35640 aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg 35700 aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt 35760 tttcccacgt tacgtaactt cccattttaa gaaaactaca attcccaaca catacaagtt 35820 actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac 35880 tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg 35938 <210> 138 <211> 34794 <212> DNA <213> Human adenovirus B2 <400> 138 catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60 aaaagtgtgg atcgtgtggt gattggctgt ggggttaacg gctaaaaggg gcggtgcgac 120 cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180 acgcataaaa aggctttttt ctcacggaac tacttagttt tcccacggta tttaacagga 240 aatgaggtag ttttgaccgg atgcaagtga aaattgttga ttttcgcgcg aaaactgaat 300 gaggaagtgt ttttctgaat aatgtggtat ttatggcagg gtggagtatt tgttcagggc 360 caggtagact ttgacccatt acgtggaggt ttcgattacc gtgtttttta cctgaatttc 420 cgcgtaccgt gtcaaagtct tctgttttta cgtaggtgtc agctgatcgc tagggtattt 480 atacctcagg gtttgtgtca agaggccact cttgagtgcc agcgagaaga gttttctcct 540 ctgcgccggc agtttaataa taaaaaaatg agagatttgc gatttctgcc tcaggaaata 600 atctctgctg agactggaaa tgaaatattg gagcttgtgg tgcacgccct gatgggagac 660 gatccggagc cacctgtgca gctttttgag cctcctacgc ttcaggaact gtatgattta 720 gaggtagagg gatcggagga ttctaatgag gaagctgtaa atggcttttt taccgattct 780 atgcttttag ctgctaatga agggttagaa ttagatccgc ctttggacac ttttgatact 840 ccaggggtaa ttgtggaaag cggtacaggt gtaagaaaat tacctgattt gagttccgtg 900 gactgtgatt tgcactgcta tgaagacggg tttcctccga gtgatgagga ggaccatgaa 960 aaggagcagt ccatgcagac tgcagcgggt gagggagtga aggctgccaa tgttggtttt 1020 cagttggatt gcccggagct tcctggacat ggctgtaagt cttgtgaatt tcacaggaaa 1080 aatactggag taaaggaact gttatgttcg ctttgttata tgagaacgca ctgccacttt 1140 atttacagta agtgtgttta agttaaaatt taaaggaata tgctgttttt cacatgtata 1200 ttgagtgtga gttttgtgct tcttattata ggtcctgtgt ctgatgctga tgaatcacca 1260 tctcctgatt ctactacctc acctcctgag attcaagcac ctgttcctgt ggacgtgcgc 1320 aagcccattc ctgtgaagct taagcctggg aaacgtccag cagtggaaaa acttgaggac 1380 ttgttacagg gtggggacgg acctttggac ttgagtacac ggaaacgtcc aagacaataa 1440 gtgttccata tccgtgttta cttaaggtga cgtcaatatt tgtgtgacag tgcaatgtaa 1500 taaaaatatg ttaactgttc actggttttt attgcttttt gggcggggac tcaggtatat 1560 aagtagaagc agacctgtgt ggttagctca taggagctgg ctttcatcca tggaggtttg 1620 ggccattttg gaagacctta ggaagactag gcaactgtta gagaacgctt cggacggagt 1680 ctccggtttt tggagattct ggttcgctag tgaattagct agggtagttt ttaggataaa 1740 acaggactat aaccaagaat ttgaaaagtt gttggtagat tgcccaggac tttttgaagc 1800 tcttaatttg ggccatcagg ttcactttaa agaaaaagtt ttatcagttt tagacttttc 1860 aaccccaggt agaactgctg ctgctgtggc ttttcttact tttatattag ataaatggat 1920 cccgcagact catttcagca ggggatacgt tttggatttc atagccacag cattgtggag 1980 aacatggaag gttcgcaaga tgaggacaat cttaggttac tggccagtgc agcctttggg 2040 tgtagcggga atcctgaggc atccaccggt catgccagcg gttctggagg aggaacagca 2100 agaggacaac ccgagagccg gcctggaccc tccagtggag gaggcggagt agctgacttg 2160 tctcctgaac tgcaacgggt gcttactgga tctacgtcca ctggacggga taggggcgtt 2220 aagagggaga gggcatctag tggtactgat gctagatctg agttggcttt aagtttaatg 2280 agtcgcagac gtcctgaaac catttggtgg catgaggttc agaaagaggg aagggatgaa 2340 gtttctgtat tgcaggagaa atattcactg gaacaggtga aaacatgttg gttggagcct 2400 gaggatgatt gggaggtggc cattaaaaat tatgccaaga tagctttgag gcctgataaa 2460 cagtataaga ttactagacg gattaatatc cggaatgctt gttacatatc tggaaatggg 2520 gctgaggtgg taatagatac tcaagacaag gcagttatta gatgctgcat gatggatatg 2580 tggcctgggg tagtcggtat ggaagcagta acttttgtaa atgttaagtt taggggagat 2640 ggttataatg gaatagtgtt tatggccaat accaaactta tattgcatgg ttgtagcttt 2700 tttggtttca acaatacctg tgtagatgcc tggggacagg ttagtgtacg gggatgtagt 2760 ttctatgcgt gttggattgc cacagctggc agaaccaaga gtcaattgtc tctgaagaaa 2820 tgcatatttc aaagatgtaa cctgggcatt ctgaatgaag gcgaagcaag ggtccgccac 2880 tgcgcttcta cagatactgg atgttttatt ttgattaagg gaaatgccag cgtaaagcat 2940 aacatgattt gcggtgcttc cgatgagagg ccttatcaaa tgctcacttg tgctggtggg 3000 cattgtaata tgctggctac tgtgcatatt gtttcccatc aacgcaaaaa atggcctgtt 3060 tttgatcaca atgtgatgac gaagtgtacc atgcatgcag gtgggcgtag aggaatgttt 3120 atgccttacc agtgtaacat gaatcatgtg aaagtgttgt tggaaccaga tgccttttcc 3180 agaatgagcc taacaggaat ttttgacatg aacatgcaaa tctggaagat cctgaggtat 3240 gatgatacga gatcgagggt acgcgcatgc gaatgcggag gcaagcatgc caggttccag 3300 ccggtgtgtg tagatgtgac tgaagatctc agaccggatc atttggttat tgcccgcact 3360 ggagcagagt tcggatccag tggagaagaa actgactaag gtgagtattg ggaaaacttt 3420 ggggtgggat tttcagatgg acagattgag taaaaatttg ttttttctgt cttgcagctg 3480 tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540 tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600 tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660 cagctgcagc tgccgccgcc gcttctgttg ccgctaacac tgtgcttgga atgggttact 3720 atggaagcat catggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780 agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttctc 3840 agcaggtggt cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900 aaaaaaatcc cagaatcaat gaataaataa acaagcttgt tgttgattta aaatcaagtg 3960 tttttatttc atttttcgcg cacggtatgc cctagaccac cgatctctat cattgagaac 4020 tcggtggatt ttttccagga tcctatagag gtgggattga atgtttagat acatgggcat 4080 taggccgtct ttggggtgga gatagctcca ttgaagggat tcatgctccg gggtagtgtt 4140 gtaaatcacc cagtcataac aaggtcgcag tgcatggtgt tgcacaatat cttttagaag 4200 taggctgatt gccacagata agcccttggt gtaggtgttt acaaaccggt tgagctggga 4260 tgggtgcatt cggggtgaaa ttatgtgcat tttggattgg atttttaagt tggcaatatt 4320 gccgccaaga tcccgtcttg ggttcatgtt atgaaggacc accaagacgg tgtatccggt 4380 acatttagga aatttatcgt gcagcttgga tggaaaagcg tggaaaaatt tggagacacc 4440 cttgtgtcct ccaagatttt ccatgcactc atccatgata atagcaatgg ggccgtgggc 4500 agcggcgcgg gcaaacacgt tccgtgggtc tgacacatca tagttatgtt cctgagttaa 4560 atcatcataa gccattttaa tgaatttggg gcggagagta ccagattggg gtatgaatgt 4620 tccttcgggc cccggagcat agttcccctc acagatttgc atttcccaag ctttcagttc 4680 cgagggtgga atcatgtcca cctggggggc tatgaaaaac accgtttctg gggcgggggt 4740 gattaattgt gatgatagca aatttctgag caattgagat ttgccacatc cggtggggcc 4800 ataaatgatt ccgattacgg gttgcaggtg gtagtttagg gaacggcaac tgccgtcttc 4860 tcgaagcaag ggggccacct cgttcatcat ttcccttaca tgcatatttt cccgcaccaa 4920 atccattagg aggcgctctc ctcctagtga tagaagttct tgtagtgagg aaaagttttt 4980 cagcggtttc agaccgtcag ccatgggcat tttggagaga gtttgctgca aaagttctag 5040 tctgttccac agttcagtga tgtgttctat ggcatctcga tccagcagac ctcctcgttt 5100 cgcgggtttg gacggctcct ggaatagggt atgagacgat gggcgtccag cgctgccagg 5160 gttcggtcct tccagggtct cagtgttcga gtcagggttg tttccgtcac agtgaagggg 5220 tgtgcgcctg cttgggcgct tgccagggtg cgcttcagac tcatcctgct ggtcgaaaac 5280 ttctgtcgct tggcgccctg tatgtcggcc aagtagcagt ttaccatgag ttcgtagttg 5340 agcgcctcgg ctgcgtggcc tttggcgcgg agcttacctt tggaagtttt cttgcatacc 5400 gggcagtata ggcatttcag cgcatacaac ttgggcgcaa ggaaaacgga ttctggggag 5460 tatgcatctg cgccgcagga ggcgcaaaca gtttcacatt ccaccagcca ggttaaatcc 5520 ggttcattgg ggtcaaaaac aagttttccg ccatattttt tgatgcgttt cttacctttg 5580 gtctccatga gttcgtgtcc tcgttgagtg acaaacaggc tgtccgtgtc cccgtagact 5640 gattttacag gcctcttctc cagtggagtg cctcggtctt cttcgtacag gaactctgac 5700 cactctgata caaaggcgcg cgtccaggcc agcacaaagg aggctatgtg ggaggggtag 5760 cgatcgttgt caaccagggg gtccaccttt tccaaagtat gcaaacacat gtcaccctct 5820 tcaacatcca ggaatgtgat tggcttgtag gtgtatttca cgtgacctgg ggtccccgct 5880 gggggggtat aaaagggggc ggttctttgc tcttcctcac tgtcttccgg atcgctgtcc 5940 aggaacgtca gctgttgggg taggtattcc ctctcgaagg cgggcatgac ctctgcactc 6000 aggttgtcag tttctaagaa cgaggaggat ttgatattga cagtgccggt tgagatgcct 6060 ttcatgaggt tttcgtccat ttggtcagaa aacacaattt ttttattgtc aagtttggtg 6120 gcaaatgatc catacagggc gttggataaa agtttggcaa tggatcgcat ggtttggttc 6180 ttttccttgt ccgcgcgctc tttggcggcg atgttgagtt ggacatactc gcgtgccagg 6240 cacttccatt cggggaagat agttgttaat tcatctggca cgattctcac ttgccaccct 6300 cgattatgca aggtaattaa atccacactg gtggccacct cgcctcgaag gggttcattg 6360 gtccaacaga gcctacctcc tttcctagaa cagaaagggg gaagtgggtc tagcataagt 6420 tcatcgggag ggtctgcatc catggtaaag attcccggaa gtaaatcctt atcaaaatag 6480 ctgatgggag tggggtcatc taaggccatt tgccattctc gagctgccag tgcgcgctca 6540 tatgggttaa ggggactgcc ccatggcatg ggatgggtga gtgcagaggc atacatgcca 6600 cagatgtcat agacgtagat gggatcctca aagatgccta tgtaggttgg atagcatcgc 6660 ccccctctga tacttgctcg cacatagtca tatagttcat gtgatggcgc tagcagcccc 6720 ggacccaagt tggtgcgatt gggtttttct gttctgtaga cgatctggcg aaagatggcg 6780 tgagaattgg aagagatggt gggtctttga aaaatgttga aatgggcatg aggtagacct 6840 acagagtctc tgacaaagtg ggcataagat tcttgaagct tggttaccag ttcggcggtg 6900 acaagtacgt ctagggcgca gtagtcaagt gtttcttgaa tgatgtcata acctggttgg 6960 tttttctttt cccacagttc gcggttgaga aggtattctt cgcgatcctt ccagtactct 7020 tctagcggaa acccgtcttt gtctgcacgg taagatccta gcatgtagaa ctgattaact 7080 gccttgtaag ggcagcagcc cttctctacg ggtagagagt atgcttgagc agcttttcgt 7140 agcgaagcgt gagtaagggc aaaggtgtct ctgaccatga ctttgagaaa ttggtatttg 7200 aagtcgatgt cgtcacaggc tccctgttcc cagagttgga agtctacccg tttcttgtag 7260 gcggggttgg gcaaagcgaa agtaacatca ttgaagagaa tcttaccggc tctgggcata 7320 aaattgcgag tgatgcgaaa aggctgtggt acttccgctc gattgttgat cacctgggca 7380 gctaggacga tctcgtcgaa accgttgatg ttgtgtccta cgatgtataa ttctatgaaa 7440 cgcggcgtgc ctctgacgtg aggtagctta ctgagctcat caaaggttag gtctgtgggg 7500 tcagataagg cgtagtgttc gagagcccat tcgtgcaggt gaggatttgc atgtaggaat 7560 gatgaccaaa gatctaccgc cagtgctgtt tgtaactggt cccgatactg acgaaaatgc 7620 cggccaattg ccattttttc tggagtgaca cagtagaagg ttctggggtc ttgttgccat 7680 cgatcccact tgagtttaat ggctagatcg tgggccatgt tgacgagacg ctcttctcct 7740 gagagtttca tgaccagcat gaaaggaact agttgtttgc caaaggatcc catccaggtg 7800 taagtttcca catcgtaggt caggaagagt ctttctgtgc gaggatgaga gccgatcggg 7860 aagaactgga tttcctgcca ccagttggag gattggctgt tgatgtgatg gaagtagaag 7920 tttctgcggc gcgccgagca ttcgtgtttg tgcttgtaca gacggccgca gtagtcgcag 7980 cgttgcacgg gttgtatctc gtgaatgagt tgtacctggc ttcccttgac gagaaatttc 8040 agtgggaagc cgaggcctgg cgattgtatc tcgtgctctt ctatattcgc tgtatcggcc 8100 tgttcatctt ctgtttcgat ggtggtcatg ctgacgagcc cccgcgggag gcaagtccag 8160 acctcggcgc gggaggggcg gagctgaagg acgagagcgc gcaggctgga gctgtccaga 8220 gtcctgagac gctgcggact caggttagta ggtagggaca gaagattaac ttgcatgatc 8280 ttttccaggg cgtgcgggag gttcagatgg tacttgattt ccacaggttc gtttgtagag 8340 acgtcaatgg cttgcagggt tccgtgtcct ttgggcgcca ctaccgtacc tttgtttttt 8400 cttttgatcg gtggtggctc tcttgcttct tgcatgctca gaagcggtga cggggacgcg 8460 cgccgggcgg cagcggttgt tccggacccg agggcatggc tggtagtggc acgtcggcgc 8520 cgcgcacggg caggttctgg tactgcgctc tgagaagact tgcgtgcgcc accacgcgtc 8580 gattgacgtc ttgtatctga cgtctctggg tgaaagctac cggccccgtg agcttgaacc 8640 tgaaagagag ttcaacagaa tcaatttcgg tatcgttaac ggcagcttgt ctcagtattt 8700 cttgtacgtc accagagttg tcctggtagg cgatctccgc catgaactgc tcgatttctt 8760 cctcctgaag atctccgcga cccgctcttt cgacggtggc cgcgaggtca ttggagatac 8820 ggcccatgag ttgggagaat gcattcatgc ccgcctcgtt ccagacgcgg ctgtaaacca 8880 cggccccctc ggagtctctt gcgcgcatca ccacctgagc gaggttaagc tccacgtgtc 8940 tggtgaagac cgcatagttg cataggcgct gaaaaaggta gttgagtgtg gtggcaatgt 9000 gttcggcgac gaagaaatac atgatccatc gtctcagcgg catttcgcta acatcgccca 9060 gagcttccaa gcgctccatg gcctcgtaga agtccacggc aaaattaaaa aactgggagt 9120 ttcgcgcgga cacggtcaat tcctcctcga gaagacggat gagttcggct atggtggccc 9180 gtacttcgcg ttcgaaggct cccgggatct cttcttcctc ttctatctct tcttccacta 9240 acatctcttc ttcgtcttca ggcgggggcg gagggggcac gcggcgacgt cgacggcgca 9300 cgggcaaacg gtcgatgaat cgttcaatga cctctccgcg gcggcggcgc atggtttcag 9360 tgacggcgcg gccgttctcg cgcggtcgca gagtaaaaac accgccgcgc atctccttaa 9420 agtggtgact gggaggttct ccgtttggga gggagagggc gctgattata cattttatta 9480 attggcccgt agggactgca cgcagagatc tgatcgtgtc aagatccacg ggatctgaaa 9540 acctttcgac gaaagcgtct aaccagtcac agtcacaagg taggctgagt acggcttctt 9600 gtgggcgggg gtggttatgt gttcggtctg ggtcttctgt ttcttcttca tctcgggaag 9660 gtgagacgat gctgctggtg atgaaattaa agtaggcagt tctaagacgg cggatggtgg 9720 cgaggagcac caggtctttg ggtccggctt gctggatacg caggcgattg gccattcccc 9780 aagcattatc ctgacatcta gcaagatctt tgtagtagtc ttgcatgagc cgttctacgg 9840 gcacttcttc ctcacccgtt ctgccatgca tacgtgtgag tccaaatccg cgcattggtt 9900 gtaccagtgc caagtcagct acgactcttt cggcgaggat ggcttgctgt acttgggtaa 9960 gggtggcttg aaagtcatca aaatccacaa agcggtggta agctcctgta ttaatggtgt 10020 aagcacagtt ggccatgact gaccagttaa ctgtctggtg accagggcgc acgagctcgg 10080 tgtatttaag gcgcgaatag gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca 10140 gatactggta ccctataaga aaatgcggcg gtggttggcg gtagagaggc catcgttctg 10200 tagctggagc gccaggggcg aggtcttcca acataaggcg gtgatagccg tagatgtacc 10260 tggacatcca ggtgattcct gcggcggtag tagaagcccg aggaaactcg cgtacgcggt 10320 tccaaatgtt gcgtagcggc atgaagtagt tcattgtagg cacggtttga ccagtgaggc 10380 gcgcgcagtc attgatgctc tatagacacg gagaaaatga aagcgttcag cgactcgact 10440 ccgtagcctg gaggaacgtg aacgggttgg gtcgcggtgt accccggttc gagacttgta 10500 ctcgagccgg ccggagccgc ggctaacgtg gtattggcac tcccgtctcg acccagccta 10560 caaaaatcca ggatacggaa tcgagtcgtt ttgctggttt ccgaatggca gggaagtgag 10620 tcctattttt tttttttgcc gctcagatgc atcccgtgct gcgacagatg cgcccccaac 10680 aacagccccc ctcgcagcag cagcagcagc aatcacaaaa ggctgtccct gcaactactg 10740 caactgccgc cgtgagcggt gcgggacagc ccgcctatga tctggacttg gaagagggcg 10800 aaggactggc acgtctaggt gcgccttcac ccgagcggca tccgcgagtt caactgaaaa 10860 aagattctcg cgaggcgtat gtgccccaac agaacctatt tagagacaga agcggcgagg 10920 agccggagga gatgcgagct tcccgcttta acgcgggtcg tgagctgcgt cacggtttgg 10980 accgaagacg agtgttgcgg gacgaggatt tcgaagttga tgaaatgaca gggatcagtc 11040 ctgccagggc acacgtggct gcagccaacc ttgtatcggc ttacgagcag acagtaaagg 11100 aagagcgtaa cttccaaaag tcttttaata atcatgtgcg aaccctgatt gcccgcgaag 11160 aagttaccct tggtttgatg catttgtggg atttgatgga agctatcatt cagaacccta 11220 ctagcaaacc tctgaccgcc cagctgtttc tggtggtgca acacagcaga gacaatgagg 11280 ctttcagaga ggcgctgctg aacatcaccg aacccgaggg gagatggttg tatgatctta 11340 tcaacattct acagagtatc atagtgcagg agcggagcct gggcctggcc gagaaggtgg 11400 ctgccatcaa ttactcggtt ttgagcttgg gaaaatatta cgctcgcaaa atctacaaga 11460 ctccatacgt tcccatagac aaggaggtga agatagatgg gttctacatg cgcatgacgc 11520 tcaaggtctt gaccctgagc gatgatcttg gggtgtatcg caatgacaga atgcatcgcg 11580 cggttagcgc cagcaggagg cgcgagttaa gcgacaggga actgatgcac agtttgcaaa 11640 gagctctgac tggagctgga accgagggtg agaattactt cgacatggga gctgacttgc 11700 agtggcagcc tagtcgcagg gctctgagcg ccgcgacggc aggatgtgag cttccttaca 11760 tagaagaggc ggatgaaggc gaggaggaag agggcgagta cttggaagac tgatggcaca 11820 acccgtgttt tttgctagat ggaacagcaa gcaccggatc ccgcaatgcg ggcggcgctg 11880 cagagccagc cgtccggcat taactcctcg gacgattgga cccaggccat gcaacgtatc 11940 atggcgttga cgactcgcaa ccccgaagcc tttagacagc aaccccaggc caaccgtcta 12000 tcggccatca tggaagctgt agtgccttcc cgctctaatc ccactcatga gaaggtcctg 12060 gccatcgtga acgcgttggt ggagaacaaa gctattcgtc cagatgaggc cggactggta 12120 tacaacgctc tcttagaacg cgtggctcgc tacaacagta gcaatgtgca aaccaatttg 12180 gaccgtatga taacagatgt acgcgaagcc gtgtctcagc gcgaaaggtt ccagcgtgat 12240 gccaacctgg gttcgctggt ggcgttaaat gctttcttga gtactcagcc tgctaatgtg 12300 ccgcgtggtc aacaggatta tactaacttt ttaagcgctt tgagactgat ggtatcagaa 12360 gtacctcaga gcgaagtgta tcagtccggt cctgattact tctttcagac tagcagacag 12420 ggcttgcaga cggtaaatct gagccaagct tttaaaaacc ttaaaggttt gtggggagtg 12480 catgccccgg taggagaaag agcaaccgtg tctagcttgt taactccgaa ctcccgccta 12540 ttattactgt tggtagctcc tttcaccgac agcggtagca tcgaccgtaa ttcctatttg 12600 ggttacctac taaacctgta tcgcgaagcc atagggcaaa gtcaggtgga cgagcagacc 12660 tatcaagaaa ttacccaagt cagtcgcgct ttgggacagg aagacactgg cagtttggaa 12720 gccactctga acttcttgct taccaatcgg tctcaaaaga tccctcctca atatgctctt 12780 actgcggagg aggagaggat ccttagatat gtgcagcaga gcgtgggatt gtttctgatg 12840 caagaggggg caactccgac tgcagcactg gacatgacag cgcgaaatat ggagcccagc 12900 atgtatgcca gtaaccgacc tttcattaac aaactgctgg actacttgca cagagctgcc 12960 gctatgaact ctgattattt caccaatgcc atcttaaacc cgcactggct gcccccacct 13020 ggtttctaca cgggcgaata tgacatgccc gaccctaatg acggatttct gtgggacgac 13080 gtggacagcg atgttttttc acctctttct gatcatcgca cgtggaaaaa ggaaggcggc 13140 gatagaatgc attcttctgc atcgctgtcc ggggtcatgg gtgctaccgc ggctgagccc 13200 gagtctgcaa gtccttttcc tagtctaccc ttttctctac acagtgtacg tagcagcgaa 13260 gtgggtagaa taagtcgccc gagtttaatg ggcgaagagg agtatctaaa cgattccttg 13320 ctcagaccgg caagagaaaa aaatttccca aacaatggaa tagaaagttt ggtggataaa 13380 atgagtagat ggaagactta tgctcaggat cacagagacg agcctgggat catggggatt 13440 acaagtagag cgagccgtag acgccagcgc catgacagac agaggggtct tgtgtgggac 13500 gatgaggatt cggccgatga tagcagcgtg ctggacttgg gtgggagagg aaggggcaac 13560 ccgtttgctc atttgcgccc tcgcttgggt ggtatgttgt aaaaaaaaat aaaaaaaaaa 13620 ctcaccaagg ccatggcgac gagcgtacgt tcgttcttct ttattatctg tgtctagtat 13680 aatgaggcga gtcgtgctag gcggagcggt ggtgtatccg gagggtcctc ctccttcgta 13740 cgagagcgtg atgcagcagc agcaggcgac ggcggtgatg caatccccac tggaggctcc 13800 ctttgtgcct ccgcgatacc tggcacctac ggagggcaga aacagcattc gttattcgga 13860 actggcacct cagtacgata ccaccaggtt gtatctggtg gacaacaagt cggcggacat 13920 tgcttctctg aactatcaga atgaccacag caacttcttg accacggtgg tgcaaaacaa 13980 tgactttacc cctacggaag ccagcaccca gaccattaac tttgatgaac gatcgcggtg 14040 gggcggtcag ctaaagacca tcatgcatac taacatgcca aacgtgaacg agtatatgtt 14100 tagtaacaag ttcaaagcgc gtgtgatggt gtccagaaaa cctcccgacg gtgctgcagt 14160 tggggatact tatgatcaca agcaggatat tttgaaatat gagtggttcg agtttacttt 14220 gccagaaggc aacttttcag ttactatgac tattgatttg atgaacaatg ccatcataga 14280 taattacttg aaagtgggta gacagaatgg agtgcttgaa agtgacattg gtgttaagtt 14340 cgacaccagg aacttcaagc tgggatggga tcccgaaacc aagttgatca tgcctggagt 14400 gtatacgtat gaagccttcc atcctgacat tgtcttactg cctggctgcg gagtggattt 14460 taccgagagt cgtttgagca accttcttgg tatcagaaaa aaacagccat ttcaagaggg 14520 ttttaagatt ttgtatgaag atttagaagg tggtaatatt ccggccctct tggatgtaga 14580 tgcctatgag aacagtaaga aagaacaaaa agccaaaata gaagctgcta cagctgctgc 14640 agaagctaag gcaaacatag ttgccagcga ctctacaagg gttgctaacg ctggagaggt 14700 cagaggagac aattttgcgc caacacctgt tccgactgca gaatcattat tggccgatgt 14760 gtctgaagga acggacgtga aactcactat tcaacctgta gaaaaagata gtaagaatag 14820 aagctataat gtgttggaag acaaaatcaa cacagcctat cgcagttggt atctttcgta 14880 caattatggc gatcccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt 14940 cacctgcgga gcagagcagg tctactggtc gcttccagac atgatgaagg atcctgtcac 15000 tttccgctcc actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt 15060 cttctcaaag agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac 15120 ctcgcttacg cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc 15180 gcccaccatt accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc 15240 gttgcgcagc agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac 15300 ctgtccctac gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac 15360 tttctaaaaa aaaaaaaaat gtccattctt atctcgccca gtaataacac cggttggggt 15420 ctgcgcgctc caagcaagat gtacggaggc gcacgcaaac gttctaccca acatcctgtc 15480 cgtgttcgcg gacattttcg cgctccatgg ggcgccctca agggccgcac tcgcgttcga 15540 accaccgtcg atgatgtaat cgatcaggtg gttgccgacg cccgtaatta tactcctact 15600 gcgcctacat ctactgtgga tgcagttatt gacagtgtag tggctgacgc tcgcaactat 15660 gctcgacgta agagccggcg aaggcgcatt gccagacgcc accgagctac cactgccatg 15720 cgagccgcaa gagctctgct acgaagagct agacgcgtgg ggcgaagagc catgcttagg 15780 gcggccagac gtgcagcttc gggcgccagc gccggcaggt cccgcaggca agcagccgct 15840 gtcgcagcgg cgactattgc cgacatggcc caatcgcgaa gaggcaatgt atactgggtg 15900 cgtgacgctg ccaccggtca acgtgtaccc gtgcgcaccc gtccccctcg cacttagaag 15960 atactgagca gtctccgatg ttgtgtccca gcggcgagga tgtccaagcg caaatacaag 16020 gaagaaatgc tgcaggttat cgcacctgaa gtctacggcc aaccgttgaa ggatgaaaaa 16080 aaaccccgca aaatcaagcg ggttaaaaag gacaaaaaag aagaggaaga tggcgatgat 16140 gggctggcgg agtttgtgcg cgagtttgcc ccacggcgac gcgtgcaatg gcgtgggcgc 16200 aaagttcgac atgtgttgag acctggaact tcggtggtct ttacacccgg cgagcgttca 16260 agcgctactt ttaagcgttc ctatgatgag gtgtacgggg atgatgatat tcttgagcag 16320 gcggctgacc gattaggcga gtttgcttat ggcaagcgta gtagaataac ttccaaggat 16380 gagacagtgt cgataccctt ggatcatgga aatcccaccc ctagtcttaa accggtcact 16440 ttgcagcaag tgttacccgt aactccgcga acaggtgtta aacgcgaagg tgaagatttg 16500 tatcccacta tgcaactgat ggtacccaaa cgccagaagt tggaggacgt tttggagaaa 16560 gtaaaagtgg atccagatat tcaacctgag gttaaagtga gacccattaa gcaggtagcg 16620 cctggtctgg gggtacaaac tgtagacatt aagattccca ctgaaagtat ggaagtgcaa 16680 actgaacccg caaagcctac tgccacctcc actgaagtgc aaacggatcc atggatgccc 16740 atgcctatta caactgacgc cgccggtccc actcgaagat cccgacgaaa gtacggtcca 16800 gcaagtctgt tgatgcccaa ttatgttgta cacccatcta ttattcctac tcctggttac 16860 cgaggcactc gctactatcg cagccgaaac agtacctccc gccgtcgccg caagacacct 16920 gcaaatcgca gtcgtcgccg tagacgcaca agcaaaccga ctcccggcgc cctggtgcgg 16980 caagtgtacc gcaatggtag tgcggaacct ttgacactgc cgcgtgcgcg ttaccatccg 17040 agtatcatca cttaatcaat gttgccgctg cctccttgca gatatggccc tcacttgtcg 17100 ccttcgcgtt cccatcactg gttaccgagg aagaaactcg cgccgtagaa gagggatgtt 17160 gggacgcgga atgcgacgct acaggcgacg gcgtgctatc cgcaagcaat tgcggggtgg 17220 ttttttacca gccttaattc caattatcgc tgctgcaatt ggcgcgatac caggcatagc 17280 ttccgtggcg gttcaggcct cgcaacgaca ttgacattgg aaaaaaacgt ataaataaaa 17340 aaaaaaaaat acaatggact ctgacactcc tggtcctgtg actatgtttt cttagagatg 17400 gaagacatca atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc 17460 tggagcgaca tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg 17520 agcgggctta aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc 17580 agtacaggac aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc 17640 gatgggatag cttccggcat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa 17700 aagataaaca gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa 17760 gaaattcctc cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg 17820 ctggtgacgc gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc 17880 accactagac cgatagcccc aatggccacc ggggtgatga aaccttctca gttgcatcga 17940 cccgtcacct tggatttgcc ccctccccct gctgctactg ctgtacccgc ttctaagcct 18000 gtcgctgccc cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca 18060 aatgcgcact ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa 18120 cgccgtcgct gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg 18180 tgtcattaca cgccgtcaca gcagcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg 18240 agttactttc aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc 18300 cggacaggat gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga 18360 cacctacttc aatctgggaa ataagtttag aaatcccacc gtagcgccga cccacgatgt 18420 gaccaccgac cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa 18480 tacatactct tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat 18540 ggccagcacg ttctttgaca ttaggggtgt gttggacaga ggtcccagtt tcaaacccta 18600 ttctggtacg gcttacaact ccctggctcc taaaggcgct ccaaatacat ctcagtggat 18660 tgcagaaggt gtaaaaaata caactggtga ggaacacgta acagaagagg aaaccaatac 18720 tactacttac acttttggca atgctcctgt aaaagctgaa gctgaaatta caaaagaagg 18780 actcccagta ggtttggaag tttcagatga agaaagtaaa ccgatttatg ctgataaaac 18840 atatcagcca gaacctcagc tgggagatga aacttggact gaccttgatg gaaaaaccga 18900 aaagtatgga ggcagggctc tcaaacccga tactaagatg aaaccatgct acgggtcctt 18960 tgccaaacct actaatgtga aaggcggtca ggcaaaacaa aaaacaacgg agcagccaaa 19020 tcagaaagtc gaatatgata tcgacatgga gttttttgat gcggcatcgc agaaaacaaa 19080 cttaagtcct aaaattgtca tgtatgcaga aaatgtaaat ttggaaactc cagacactca 19140 tgtagtgtac aaacctggaa cagaagacac aagttccgaa gctaatttgg gacaacaatc 19200 tatgcccaac agacccaact acattggctt cagagataac tttattggac ttatgtacta 19260 taacagtact ggtaacatgg gggtgctggc tggtcaagcg tctcagttaa atgcagtggt 19320 tgacttgcag gacagaaaca cagaactttc ttaccaactc ttgcttgact ctctgggcga 19380 cagaaccaga tactttagca tgtggaatca ggctgtggac agttatgatc ctgatgtacg 19440 tgttattgaa aatcatggtg tggaagatga acttcccaac tactgttttc cactggacgg 19500 cataggtgtt ccaacaacca gttacaaatc aatagttcca aatggagaca atgcgcctaa 19560 ttggaaggaa cctgaagtaa atggaacaag tgagatcgga cagggtaatt tgtttgccat 19620 ggaaattaac cttcaagcca atctatggcg aagtttcctt tattccaatg tggctctata 19680 tctcccagac tcgtacaaat acaccccgtc caatgtcact cttccagaaa acaaaaacac 19740 ctacgactac atgaacgggc gggtggtgcc gccatctcta gtagacacct atgtgaacat 19800 tggtgccagg tggtctctgg atgccatgga caatgtcaac ccattcaacc accaccgtaa 19860 cgctggcttg cgttaccgat ccatgcttct gggtaacgga cgttatgtgc ctttccacat 19920 acaagtgcct caaaaattct tcgctgttaa aaacctgctg cttctcccag gctcctacac 19980 ttatgagtgg aactttagga aggatgtgaa catggttcta cagagttccc tcggtaacga 20040 cctgcgggta gatggcgcca gcatcagttt cacgagcatc aacctctatg ctactttttt 20100 ccccatggct cacaacaccg cttccaccct tgaagccatg ctgcggaatg acaccaatga 20160 tcagtcattc aacgactacc tatctgcagc taacatgctc taccccattc ctgccaatgc 20220 aaccaatatt cccatttcca ttccttctcg caactgggcg gctttcagag gctggtcatt 20280 taccagactg aaaaccaaag aaactccctc tttggggtct ggatttgacc cctactttgt 20340 ctattctggt tctattccct acctggatgg taccttctac ctgaaccaca cttttaagaa 20400 ggtttccatc atgtttgact cttcagtgag ctggcctgga aatgacaggt tactatctcc 20460 taacgaattt gaaataaagc gcactgtgga tggcgaaggc tacaacgtag cccaatgcaa 20520 catgaccaaa gactggttct tggtacagat gctcgccaac tacaacatcg gctatcaggg 20580 cttctacatt ccagaaggat acaaagatcg catgtattca tttttcagaa acttccagcc 20640 catgagcagg caggtggttg atgaggtcaa ttacaaagac ttcaaggccg tcgccatacc 20700 ctaccaacac aacaactctg gctttgtggg ttacatggct ccgaccatgc gccaaggtca 20760 accctatccc gctaactatc cctatccact cattggaaca actgccgtaa atagtgttac 20820 gcagaaaaag ttcttgtgtg acagaaccat gtggcgcata ccgttctcga gcaacttcat 20880 gtctatgggg gcccttacag acttgggaca gaatatgctc tatgccaact cagctcatgc 20940 tctggacatg acctttgagg tggatcccat ggatgagccc accctgcttt atcttctctt 21000 cgaagttttc gacgtggtca gagtgcatca gccacaccgc ggcatcatcg aggcagtcta 21060 cctgcgtaca ccgttctcgg ccggtaacgc taccacgtaa gaagcttctt gcttcttgca 21120 aatagcagct gcaaccatgg cctgcggatc ccaaaacggc tccagcgagc aagagctcag 21180 agccattgtc caagacctgg gttgcggacc ctattttttg ggaacctacg ataagcgctt 21240 cccggggttc atggcccccg ataagctcgc ctgtgccatt gtaaatacgg ccggacgtga 21300 gacgggggga gagcactggt tggctttcgg ttggaaccca cgttctaaca cctgctacct 21360 ttttgatcct tttggattct cggatgatcg tctcaaacag atttaccagt ttgaatatga 21420 gggtctcctg cgccgcagcg ctcttgctac caaggaccgc tgtattacgc tggaaaaatc 21480 tacccagacc gtgcagggtc cccgttctgc cgcctgcgga cttttctgct gcatgttcct 21540 tcacgccttt gtgcactggc ctgaccgtcc catggacgga aaccccacca tgaaattgct 21600 aactggagtg ccaaacaaca tgcttcattc tcctaaagtc cagcccaccc tgtgtgacaa 21660 tcaaaaagca ctctaccatt ttcttaatac ccattcgcct tattttcgct cccatcgtac 21720 acacatcgaa agggccactg cgttcgaccg tatggatgtt caataatgac tcatgtaaac 21780 aacgtgttca ataaacatca ctttattttt ttacatgtat caaggctctg cattacttat 21840 ttatttacaa gtcgaatggg ttctgacgag aatcagaatg acccgcaggc agtgatacgt 21900 tgcggaactg atacttgggt tgccacttga attcgggaat caccaacttg ggaaccggta 21960 tatcgggcag gatgtcactc cacagctttc tggtcagctg caaagctcca agcaggtcag 22020 gagccgaaat cttgaaatca caattaggac cagtgctttg agcgcgagag ttgcggtaca 22080 ccggattgca gcactgaaac accatcagcg acggatgtct cacgcttgcc agcacggtgg 22140 gatctgcaat catgcccaca tccagatctt cagcattggc aatgctgaac ggggtcatct 22200 tgcaggtctg cctacccatg gcgggcaccc aattaggctt gtggttgcaa tcgcagtgca 22260 gggggatcag tatcatcttg gcctgatcct gtctgattcc tggatacacg gctctcatga 22320 aagcatcata ttgcttgaaa gcctgctggg ctttactacc ctcggtataa aacatcccgc 22380 aggacctgct cgaaaactgg ttagctgcac agccggcatc attcacacag cagcgggcgt 22440 cattgttagc tatttgcacc acacttctgc cccagcggtt ttgggtgatt ttggttcgct 22500 cgggattctc ctttaaggct cgttgtccgt tctcgctggc cacatccatc tcgataatct 22560 gctccttctg aatcataata ttgccatgca ggcacttcag cttgccctca taatcattgc 22620 agccatgagg ccacaacgca cagcctgtac attcccaatt atggtgggcg atctgagaaa 22680 aagaatgtat cattccctgc agaaatcttc ccatcatcgt gctcagtgtc ttgtgactag 22740 tgaaagttaa ctggatgcct cggtgctcct cgtttacgta ctggtgacag atgcgcttgt 22800 attgttcgtg ttgctcaggc attagtttaa aagaggttct aagttcgtta tccagcctgt 22860 acttctccat cagcagacac atcacttcca tgcctttctc ccaagcagac accaggggca 22920 agctaatcgg attcttaaca gtgcaggcag cagctccttt agccagaggg tcatctttag 22980 cgatcttctc aatgcttctt ttgccatcct tctcaacgat gcgcacgggc gggtagctga 23040 aacccactgc tacaagttgc gcctcttctc tttcttcttc gctgtcttga ctgatgtctt 23100 gcatggggat atgtttggtc ttccttggct tctttttggg gggtatcgga ggaggaggac 23160 tgtcgctccg ttccggagac agggaggatt gtgacgtttc gctcaccatt accaactgac 23220 tgtcggtaga agaacctgac cccacacggc gacaggtgtt tctcttcggg ggcagaggtg 23280 gaggcgattg cgaagggctg cggtccgacc tggaaggcgg atgactggca gaaccccttc 23340 cgcgttcggg ggtgtgctcc ctgtggcggt cgcttaactg atttccttcg cggctggcca 23400 ttgtgttctc ctaggcagag aaacaacaga catggaaact cagccattgc tgtcaacatc 23460 gccacgagtg ccatcacatc tcgtcctcag cgacgaggaa aaggagcaga gcttaagcat 23520 tccaccgccc agtcctgcca ccacctctac cctagaagat aaggaggtcg acgcatctca 23580 tgacatgcag aataaaaaag cgaaagagtc tgagacagac atcgagcaag acccgggcta 23640 tgtgacaccg gtggaacacg aggaagagtt gaaacgcttt ctagagagag aggatgaaaa 23700 ctgcccaaaa caacgagcag ataactatca ccaagatgct ggaaataggg atcagaacac 23760 cgactacctc atagggcttg acggggaaga cgcgctcctt aaacatctag caagacagtc 23820 gctcatagtc aaggatgcat tattggacag aactgaagtg cccatcagtg tggaagagct 23880 cagccgcgcc tacgagctta acctcttttc acctcgtact ccccccaaac gtcagccaaa 23940 cggcacctgc gagccaaatc ctcgcttaaa cttttatcca gcttttgctg tgccagaagt 24000 actggctacc tatcacatct tttttaaaaa tcaaaaaatt ccagtctcct gccgcgctaa 24060 tcgcacccgc gccgatgccc tactcaatct gggacctggt tcacgcttac ctgatatagc 24120 ttccttggaa gaggttccaa agatcttcga gggtctgggc aataatgaga ctcgggccgc 24180 aaatgctctg caaaagggag aaaatggcat ggatgagcat cacagcgttc tggtggaatt 24240 ggaaggcgat aatgccagac tcgcagtact caagcgaagc atcgaggtca cacacttcgc 24300 atatcccgct gtcaacctgc cccctaaagt catgacggcg gtcatggacc agttactcat 24360 taagcgcgca agtccccttt cagaagacat gcatgaccca gatgcctgtg atgagggtaa 24420 accagtggtc agtgatgagc agctaacccg atggctgggc accgactctc ccagggattt 24480 ggaagagcgt cgcaagctta tgatggccgt ggtgctggtt accgtagaac tagagtgtct 24540 ccgacgtttc tttaccgatt cagaaacctt gcgcaaactc gaagagaatc tgcactacac 24600 ttttagacac ggctttgtgc ggcaggcatg caagatatct aacgtggaac tcaccaacct 24660 ggtttcctac atgggtattc tgcatgagaa tcgcctagga caaagcgtgc tgcacagcac 24720 cctgaagggg gaagcccgcc gtgattacat ccgcgattgt gtctatctgt acctgtgcca 24780 cacgtggcaa accggcatgg gtgtatggca gcaatgttta gaagaacaga acttgaaaga 24840 gcttgacaag ctcttacaga aatctcttaa ggttctgtgg acagggttcg acgagcgcac 24900 cgtcgcttcc gacctggcag acctcatctt cccagagcgt ctcagggtta ctttgcgaaa 24960 cggattgcct gactttatga gccagagcat gcttaacaat tttcgctctt tcatcctgga 25020 acgctccggt atcctgcccg ccacctgctg cgcactgccc tccgactttg tgcctctcac 25080 ctaccgcgag tgccccccgc cgctatggag tcactgctac ctgttccgtc tggccaacta 25140 tctctcctac cactcggatg tgatcgagga tgtgagcgga gacggcttgc tggagtgtca 25200 ctgccgctgc aatctgtgca cgccccaccg gtccctagct tgcaaccccc agttgatgag 25260 cgaaacccag ataataggca cctttgaatt gcaaggcccc agcagccaag gcgatgggtc 25320 ttctcctggg caaagtttaa aactgacccc gggactgtgg acctccgcct acttgcgcaa 25380 gtttgctccg gaagattacc acccctatga aatcaagttc tatgaggacc aatcacagcc 25440 tccaaaggcc gaactttcgg cctgcgtcat cacccagggg gcaattctgg cccaattgca 25500 agccatccaa aaatcccgcc aagaatttct actgaaaaag ggtaaggggg tctaccttga 25560 cccccagacc ggcgaggaac tcaacacaag gttccctcag gatgtcccaa cgacgagaaa 25620 acaagaagtt gaaggtgcag ccgccgcccc cagaagatat ggaggaagat tgggacagtc 25680 aggcagagga ggcggaggag gacagtctgg aggacagtct ggaggaagac agtttggagg 25740 aggaaaacga ggaggcagag gaggtggaag aagtaaccgc cgacaaacag ttatcctcgg 25800 ctgcggagac aagcaacagc gctaccatct ccgctccgag tcgaggaacc cggcggcgtc 25860 ccagcagtag atgggacgag accggacgct tcccgaaccc aaccagcgct tccaagaccg 25920 gtaagaagga tcggcaggga tacaagtcct ggcgggggca taagaatgcc atcatctcct 25980 gcttgcatga gtgcgggggc aacatatcct tcacgcggcg ctacttgcta ttccaccatg 26040 gggtgaactt tccgcgcaat gttttgcatt actaccgtca cctccacagc ccctactata 26100 gccagcaaat cccggcagtc tcgacagata aagacagcgg cggcgacctc caacagaaaa 26160 ccagcagcgg cagttagaaa atacacaaca agtgcagcaa caggaggatt aaagattaca 26220 gccaacgagc cagcgcaaac ccgagagtta agaaatcgga tctttccaac cctgtatgcc 26280 atcttccagc agagtcgggg tcaagagcag gaactgaaaa taaaaaaccg atctctgcgt 26340 tcgctcacca gaagttgttt gtatcacaag agcgaagatc aacttcagcg cactctcgag 26400 gacgccgagg ctctcttcaa caagtactgc gcgctgactc ttaaagagta ggcagcgacc 26460 gcgcttattc aaaaaaggcg ggaattacat catcctcgac atgagtaaag aaattcccac 26520 gccttacatg tggagttatc aaccccaaat gggattggcg gcaggcgcct cccaggacta 26580 ctccacccgc atgaattggc tcagcgccgg gccttctatg atttctcgag ttaatgatat 26640 acgcgcctac cgaaaccaaa tacttttgga acagtcagct cttaccacca cgccccgcca 26700 acaccttaat cccagaaatt ggcccgccgc cctagtgtac caggaaagtc ccgctcccac 26760 cactgtatta cttcctcgag acgcccaggc cgaagtccaa atgactaatg caggtgcgca 26820 gttagctggc ggctccaccc tatgtcgtca caggcctcgg cataatataa aacgcctgat 26880 gatcagaggc cgaggtatcc agctcaacga cgagtcggtg agctctccgc ttggtctacg 26940 accagacgga atctttcaga ttgccggctg cgggagatct tccttcaccc ctcgtcaggc 27000 tgttctgact ttggaaagtt cgtcttcgca accccgctcg ggcggaatcg ggaccgttca 27060 atttgtggag gagtttactc cctctgtcta cttcaacccc ttctccggat ctcctgggca 27120 ttacccggac gagttcatac cgaacttcga cgcgattagc gagtcagtgg acggctacga 27180 ttgatgtctg gtgacgcggc tgagctatct cggctgcgac atctagacca ctgccgccgc 27240 tttcgctgct ttgcccggga actcattgag ttcatctact tcgaactccc caaggatcac 27300 cctcaaggtc cggcccacgg agtgcggatt tctatcgaag gcaaaataga ctctcgcctg 27360 caacgaattt tctcccagcg gcccgtgctg atcgagcgag accagggaaa caccacggtt 27420 tccatctact gcatttgtaa tcaccccgga ttgcatgaaa gcctttgctg tcttatgtgt 27480 actgagttta ataaaaactg aattaagact ctcctacgga ctgccgcttc ttcaacccgg 27540 attttacaac cagaagaacg aaacttttcc tgtcgtccag gactctgtta acttcacctt 27600 tcctactcac aaactagaag ctcaacgact acaccgcttt tccagaagca ttttccctac 27660 taatactact ttcaaaaccg gaggtgagct ccaaggtctt cctacagaaa acccttgggt 27720 ggaagcgggc cttgtagtgc taggaattct tgcgggtggg cttgtgatta ttctttgcta 27780 cctatacaca ccttgcttca ctttcttagt ggtgttgtgg tattggttta aaaaatgggg 27840 cccatactag tcttgcttgt tttactttcg cttttggaac cgggttctgc caattacgat 27900 ccatgtctag acttcgaccc agaaaactgc acacttactt ttgcacccga cacaagccgc 27960 atctgtggag ttcttattaa gtgcggatgg gaatgcaggt ccgttgaaat tacacacaat 28020 aacaaaacct ggaacaatac cttatccacc acatgggagc caggagttcc cgagtggtac 28080 actgtctctg tccgaggtcc tgacggttcc atccgcatta gtaacaacac tttcattttt 28140 tctgaaatgt gcgatctggc catgttcatg agcaaacagt attctctatg gcctcctagc 28200 aaggacaaca tcgtaacgtt ctccattgct tattgcttgt gcgcttgcct tcttactgct 28260 ttactgtgcg tatgcataca cctgcttgta accactcgca tcaaaaacgc caataacaaa 28320 gaaaaaatgc cttaacctct ttctgtttac agacatggct tctcttacat ctctcatatt 28380 tgtcagcatt gtcactgccg ctcatggaca aacagtcgtc tctatccctc taggacataa 28440 ttacactctc ataggacccc caatcacttc agaggtcatc tggaccaaac tgggaagcgt 28500 tgattacttt gatataatct gcaacaaaac aaaaccaata atagtaactt gcaacataca 28560 aaatcttaca ttgattaatg ttagcaaagt ttacagcggt tactattatg gttatgacag 28620 atacagtagt caatatagaa attacttggt tcgtgttacc cagttgaaaa ccacgaaaat 28680 gccaaatatg gcaaagattc gatccgatga caattctcta gaaactttta catctcccac 28740 cacacccgac gaaaaaaaca tcccagattc aatgattgca attgttgcag cggtggcagt 28800 ggtgatggca ctaataataa tatgcatgct tttatatgct tgtcgctaca aaaagtttca 28860 tcctaaaaaa caagatctcc tactaaggct taacatttaa tttcttttta tacagccatg 28920 gtttccacta ccacattcct tatgcttact agtctcgcaa ctctgacttc tgctcgctca 28980 cacctcactg taactatagg ctcaaactgc acactaaaag gacctcaagg tggtcatgtc 29040 ttttggtgga gaatatatga caatggatgg tttacaaaac catgtgacca acctggtaga 29100 tttttctgca acggcagaga cctaaccatt atcaacgtga cagcaaatga caaaggcttc 29160 tattatggaa ccgactataa aagtagttta gattataaca ttattgtact gccatctacc 29220 actccagcac cccgcacaac tactttctct agcagcagtg tcgctaacaa tacaatttcc 29280 aatccaacct ttgccgcgct tttaaaacgc actgtgaata attctacaac ttcacataca 29340 acaatttcca cttcaacaat cagcattatc gctgcagtga caattggaat atctattctt 29400 gtttttacca taacctacta cgcctgctgc tatagaaaag acaaacataa aggtgatcca 29460 ttacttagat ttgatattta atttgttctt ttttttttta tttacagtat ggtgaacacc 29520 aatcatggta cctagaaatt tcttcttcac catactcatt tgtgcattta atgtttgcgc 29580 tactttcaca gcagtagcca cagcaacccc agactgtata ggagcatttg cttcctatgc 29640 actttttgct tttgttactt gcatctgcgt atgtagcata gtctgcctgg ttattaattt 29700 tttccaactt atagactgga tccttgtgcg aattgcctac ctgcgccacc atcccgaata 29760 ccgcaaccaa aatatcgcgg cacttcttag actcatctaa aaccatgcag gctatactac 29820 caatattttt gcttctattg cttccctacg ctgtctcaac cccagctgcc tatagtactc 29880 caccagaaca ccttagaaaa tgcaaattcc aacaaccgtg gtcatttctt gcttgctatc 29940 gagaaaaatc agaaattccc ccaaatttaa taatgattgc tggaataatt aatataatct 30000 gttgcaccat aatttcattt ttgatatacc ccctatttga ttttggctgg aatgctccca 30060 atgcacatga tcatccacaa gacccagagg aacacattcc cctacaaaac atgcaacatc 30120 caatagcgct aatagattac gaaagtgaac cacaaccccc actactccct gctattagtt 30180 acttcaacct aaccggcgga gatgactgaa acactcacca cctccaattc cgccgaggat 30240 ctgctcgata tggacggccg cgtctcagaa cagcgactcg cccaactacg catccgccag 30300 cagcaggaac gcgcggccaa agagctcaga gatgtcatcc aaattcacca atgcaaaaaa 30360 ggcatattct gtttggtaaa acaagccaag atatcctacg agatcaccgc tactgaccat 30420 cgcctctctt acgaacttgg cccccaacga caaaaattta cctgcatggt gggaatcaac 30480 cccatagtta tcacccagca aagtggagat actaagggtt gcattcactg ctcctgcgat 30540 tccatcgagt gcacctacac cctgctgaag accctatacg gcctaagaga cctgctacca 30600 atgaattaaa aaatgattaa taaaaaatca cttacttgaa atcagcaata aggtctctgt 30660 tgaaattttc tcccagcagc acctcacttc cctcttccca actctggtat tctaaacccc 30720 gttcagcggc atactttctc catactttaa aggggatgtc aaattttagc tcctctcctg 30780 tacccacaat cttcatgtct ttcttcccag atgaccaaga gagtccggct cagtgactcc 30840 ttcaaccctg tctaccccta tgaagatgaa agcacctccc aacacccctt tataaaccca 30900 gggtttattt ccccaaatgg cttcacacaa agcccaaacg gagttcttac tttaaaatgt 30960 ttaaccccac taacaaccac aggcggatct ctacagctaa aagtgggagg gggacttaca 31020 gtggatgaca ccaacggttt tttgaaagaa aacataagtg ccaccacacc actcgttaag 31080 actggtcact ctataggttt accactagga gccggattgg gaacgaatga aaataaactt 31140 tgtatcaaat taggacaagg acttacattc aattcaaaca acatttgcat tgatgacaat 31200 attaacacct tatggacagg agtcaacccc accgaagcca actgtcaaat catgaactcc 31260 agtgaatcta atgattgcaa attaattcta acactagtta aaactggagc actagtcact 31320 gcatttgttt atgttatagg agtatctaac aattttaata tgctaactac acacagaaat 31380 ataaatttta ctgcagagct gtttttcgat tctactggta atttactaac tagactctca 31440 tccctcaaaa ctccacttaa tcataaatca ggacaaaaca tggctactgg tgccattact 31500 aatgctaaag gtttcatgcc cagcacgact gcctatcctt tcaatgataa ttctagagaa 31560 aaagaaaact acatttacgg aacttgttac tacacagcta gtgatcgcac tgcttttccc 31620 attgacatat ctgtcatgct taaccgaaga gcaataaatg acgagacatc atattgtatt 31680 cgtataactt ggtcctggaa cacaggagat gccccagagg tgcaaacctc tgctacaacc 31740 ctagtcacct ccccatttac cttttactac atcagagaag acgactgaca aataaagttt 31800 aacttgttta tttgaaaatc aattcacaaa atccgagtag ttattttgcc tcccccttcc 31860 catttaacag aatacaccaa tctctcccca cgcacagctt taaacatttg gataccatta 31920 gatatagaca tggttttaga ttccacattc caaacagttt cagagcgagc caatctgggg 31980 tcagtgatag ataaaaatcc atcgggatag tcttttaaag cgctttcaca gtccaactgc 32040 tgcggatgcg actccggagt ctggatcacg gtcatctgga agaagaacga tgggaatcat 32100 aatccgaaaa cggtatcgga cgattgtgtc tcatcaaacc cacaagcagc cgctgtctgc 32160 gtcgctccgt gcgactgctg tttatgggat cagggtccac agtgtcctga agcatgattt 32220 taatagccct taacatcaac tttctggtgc gatgcgcgca gcaacgcatt ctgatttcac 32280 tcaaatcttt gcagtaggta caacacatta ttacaatatt gtttaataaa ccataattaa 32340 aagcgctcca gccaaaactc atatctgata taatcgcccc tgcatgacca tcataccaaa 32400 gtttaatata aattaaatga cgttccctca aaaacacact acccacatac atgatctctt 32460 ttggcatgtg catattaaca atctgtctgt accatggaca acgttggtta atcatgcaac 32520 ccaatataac cttccggaac cacactgcca acaccgctcc cccagccatg cattgaagtg 32580 aaccctgctg attacaatga caatgaagaa cccaattctc tcgaccgtga atcacttgag 32640 aatgaaaaat atctatagtg gcacaacata gacataaatg catgcatctt ctcataattt 32700 ttaactcctc aggatttaga aacatatccc agggaatagg aagctcttgc agaacagtaa 32760 agctggcaga acaaggaaga ccacgaacac aacttacact atgcatagtc atagtatcac 32820 aatctggcaa cagcgggtgg tcttcagtca tagaagctcg ggtttcattt tcctcacaac 32880 gtggtaactg ggctctggtg taagggtgat gtctggcgca tgatgtcgag cgtgcgcgca 32940 accttgtcat aatggagttg cttcctgaca ttctcgtatt ttgtatagca aaacgcggcc 33000 ctggcagaac acactcttct tcgccttcta tcctgccgct tagcgtgttc cgtgtgatag 33060 ttcaagtaca accacactct taagttggtc aaaagaatgc tggcttcagt tgtaatcaaa 33120 actccatcgc atctaatcgt tctgaggaaa tcatccacgg tagcatatgc aaatcccaac 33180 caagcaatgc aactggattg tgtttcaagc aggagaggag agggaagaga cggaagaacc 33240 atgttaattt ttattccaaa cgatctcgca gtacttcaaa ttgtagatcg cgcagatggc 33300 atctctcgcc cccactgtgt tggtgaaaaa gcacagctag atcaaaagaa atgcgatttt 33360 caaggtgctc aacggtggct tccagcaaag cctccacgcg cacatccaag aacaaaagaa 33420 taccaaaaga aggagcattt tctaactcct caatcatcat attacattcc tgcaccattc 33480 ccagataatt ttcagctttc cagccttgaa ttattcgtgt cagttcttgt ggtaaatcca 33540 atccacacat tacaaacagg tcccggaggg cgccctccac caccattctt aaacacaccc 33600 tcataatgac aaaatatctt gctcctgtgt cacctgtagc gaattgagaa tggcaacatc 33660 aattgacatg cccttggctc taagttcttc tttaagttct agttgtaaaa actctctcat 33720 attatcacca aactgcttag ccagaagccc cccgggaaca agagcagggg acgctacagt 33780 gcagtacaag cgcagacctc cccaattggc tccagcaaaa acaagattgg aataagcata 33840 ttgggaaccg ccagtaatat catcgaagtt gctggaaata taataaggca gagtttcttg 33900 taaaaattga ataaaagaaa aatttgccaa aaaaacattc aaaacctctg ggatgcaaat 33960 gcaataggtt accgcgctgc gctccaacat tgttagtttt gaattagtct gcaaaaataa 34020 aaaaaaaaac aagcgtcata tcatagtagc ctgacgaaca gatggataaa tcagtctttc 34080 catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt catcatgatt 34140 aaacaacagc accgaaagtt cctcgcggtg accagcatga ataattcttg atgaagcata 34200 caatccagac atgttagcat cagttaacga gaaaaaacag ccaacatagc ctttgggtat 34260 aattatgctt aatcgtaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34320 aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgtcg cccccggtcc 34380 ctctaaatac acatacaaag cctcatcagc catggcttac cagacaaagt acagcgggca 34440 cacaaagcac aagctctaaa gtgactctcc aacctctcca caatatatat atacacaagc 34500 cctaaactga cgtaatggga gtaaagtgta aaaaatcccg ccaaacccaa cacacacccc 34560 gaaactgcgt caccagggaa aagtacagtt tcacttccgc aatcccaaca ggcgtaactt 34620 cctctttctc acggtacgtg atatcccact aacttgcaac gtcattttcc cacggtcgca 34680 ccgccccttt tagccgttaa ccccacagcc aatcaccaca cgatccacac tttttaaaat 34740 cacctcattt acatattggc accattccat ctataaggta tattattgat gatg 34794 <210> 139 <211> 35343 <212> DNA <213> Human adenovirus type 3 <400> 139 ctatctatat aatatacctt atagatggaa tggtgccaac atgtaaatga ggtaatttaa 60 aaaagtgcgc gctgtgtggt gattggctgc ggggttaacg gctaaaaggg gcggcgcgac 120 cgtgggaaaa tgacgtgact tatgtgggag gagttatgtt gcaagttatt acggtaaatg 180 tgacgtaaaa cgaggtgtgg tttgaacacg gaagtagaca gttttcccac gcttactgac 240 aggatatgag gtagttttgg gcggatgcaa gtgaaaattc tccattttcg cgcgaaaact 300 aaatgaggaa gtgaatttct gagtcatttc gcggttatgc cagggtggag tatttgccga 360 gggccgagta gactttgacc gtttacgtgg aggtttcgat taccgtgttt ttcacctaaa 420 tttccgcgta cggtgtcaaa gttctgtgtt tttacgtagg tgtcagctga tcgctagggt 480 atttaaacct gacgagttcc gtcaagaggc cactcttgag tgccagcgag aagagttttc 540 tcctccgcgc cgcaagtcag ttctgcgctt tgaaaatgag acacctgcgc ttcctgccac 600 aggaggttat ctccagtgag accgggatcg aaatactgga gtttgtggta aataccctaa 660 tgggagacga cccggaaccg ccagtgcagc ctttcgatcc acctacgctg cacgatctgt 720 atgatttaga gatagacggg ccggaggatc ccaatgagga agctgtgaat gggtttttta 780 ctgattctat gctgctagct gctgatgaag gattggacat aaaccctcct cctgagacac 840 ttgttacccc aggggtggtt gtggaaagcg gcataggtgg gaaaaaattg cctgatctgg 900 gagcagctga aatggacttg cgttgttatg aagagggttt tcctcccagt gatgatgaag 960 atggggaaac tgagcagtcc atccataccg cagtaaatga gggagtaaaa gctgccagcg 1020 atgtttttaa gttggactgt ccggagctgc ctggacatgg ctgtaagtct tgtgaatttc 1080 acaggaataa cactggaatg aaagaactat tgtgctcgct ttgctatatg agaatgcact 1140 gccactttat ttacagtaag tgtatttaag tgaaatttaa aggaatagtg tagctattta 1200 ataactgttg aatggtagat ttatgttttt ttcttgcgat tttttgtagg tcctgtgtct 1260 gatgatgagt caccttctcc tgattcaact acctcacctc ctgaaattca ggcgcccgca 1320 cctgcaaacg tatgcaagcc cattcctgtg aagcctaagc ctgggaaacg ccctgctgtg 1380 gataagcttg aggacttgtt ggagggtggg gatggacctt tggaccttag tacccggaaa 1440 ctgccaaggc aatgagtgcc ctgcagctgt gtttatttaa tgtgacgtca tgtaataaaa 1500 ttatgtcagc tgctgagtgt tttattactt cttgggtggg gacttggata tataagtagg 1560 agcagatctg tgtggttagc tcacagcaac ctgctgccat ccatggaggt ttgggctatc 1620 ttggaagacc tcagacagac taagctactg ctagaaaacg cctcggacgg agtctctggc 1680 ctttggagat tctggttcgg tggtgatcta gctaggctag tgtttaggat aaaacaggac 1740 tacagggaag aatttgaaaa gttattggac gatagtccgg gactttttga agctcttaac 1800 ttgggtcatc aggctcattt taaggagaag gttttatcag ttttagattt ttctactcct 1860 ggtagaactg ctgctgctgt agcttttctt acttttatat tggataaatg gatccgccaa 1920 actcacttca gcaagggata cgttttggat ttcatagcag cagctttgtg gagaacatgg 1980 aaggctcgca ggatgaggac aatcttagat tactggccag tgcagcctct gggagtagca 2040 gggatactga gacacccacc gaccatgcca gcggttctgc aggaggagca gcaggaggac 2100 aatccgagag ccggcctgga ccctccggtg gaggagtagc tgacctgttt cctgaactgc 2160 gacgggtgct tactaggtct acgaccagtg gacagaacag gggaattaag agggagagga 2220 atcctagtgg gaataattca agaaccgagt tggctttaag tttaatgagc cgcaggcgtc 2280 ctgaaactgt ttggtggcat gaggttcaga gcgaaggcag ggatgaagtt tcaatattgc 2340 aggagaaata ttcactagaa caacttaaga cctgttggtt ggaacctgag gatgattggg 2400 aggtggccat taggaattat gctaagatat ctctgaggcc tgataaacaa tatagaatta 2460 ctaagaagat taatattaga aatgcatgct acatatcagg gaatggggca gaggttataa 2520 tagatacaca agataaagca gtttttagat gttgtatgat gggtatgtgg ccaggggttg 2580 tcggcatgga agcagtaaca cttatgaata ttaggtttaa aggggatggg tataatggca 2640 ttgtatttat ggctaacact aagctgattc tacatggttg tagctttttt gggtttaata 2700 atacgtgtgt agaagcttgg gggcaagtta gtgtgagggg ttgtagtttt tatgcatgct 2760 ggattgcaac atcaggtagg gtcaagagtc agttgtctgt gaagaaatgc atgtttgaga 2820 gatgtaatct tggcatactg aatgaaggtg aagcaagggt ccgccactgc gcagctacag 2880 aaactggctg cttcattcta ataaagggaa atgccagtgt gaagcataat atgatctgtg 2940 gacattcgga tgagaggcct tatcagatgc tgacctgcgc tggtggacat tgcaatattc 3000 ttgctaccgt gcatatcgtt tcacatgcac gcaaaaaatg gcctgtattt gaacataatg 3060 tgattaccaa gtgcaccatg cacataggtg gtcgcagggg aatgtttatg ccttaccagt 3120 gtaacatgaa tcatgtgaag gtaatgttgg aaccagatgc cttttccaga gtgagcttaa 3180 caggaatctt tgatatgaat attcaactat ggaagatcct gagatatgat gacactaaac 3240 caagggtgcg cgcatgcgaa tgcggaggca agcatgctag attccagccg gtgtgcgtgg 3300 atgtgactga agacttgaga cccgatcatt tggtgcttgc ctgcactgga gcggagttcg 3360 gttctagtgg tgaagaaact gactaaagtg agtagtgggg caagatgtgg atggggactt 3420 tcaggttggt aaggtgggca gattgggtaa attttgttaa tttctgtctt gcagctgcca 3480 tgagtggaag cgcttctttt gaggggggag tatttagccc ttatctgacg ggcaggctcc 3540 caccatgggc aggagttcgt cagaatgtca tgggatccac tgtggatggg agacccgtcc 3600 agcccgccaa ttcctcaacg ctgacctatg ccactttgag ttcgtcacca ttggatgcag 3660 ctgcagccgc cgccgctact gctgccgcca acaccatcct tggaatgggc tattatggaa 3720 gcatcgttgc caattccagt tcctctaata acccttcaac cctggctgag gacaagctac 3780 ttgttctctt ggcgcagctc gaggccttaa cccaacgctt aggcgaactg tctaagcagg 3840 tggcccagtt gcgtgagcaa actgagtctg ctgttgccac agcaaagtct aaataaagat 3900 ctcaaatcaa taaataaaga aatacttgat ataaaacaaa tgaatgttta tttgattttt 3960 cgcgcgcggt atgccctgga ccatcggtct cgatcattga gaacgcggtg gatcttttcc 4020 agtaccctgt aaaggtggga ttgaatgttt agatacatgg gcattagtcc gtctcggggg 4080 tggagatagc tccattgaag agcctcttgc tccggggtag tgttataaat cacccagtca 4140 tagcaaggtc ggagtgcatg gtgttgcaca atatctttta ggagcagact aattgcaacg 4200 gggaggccct tagtgtaggt gtttacaaat ctgttgagct gggacgggtg catccggggt 4260 gaaattatat gcattttgga ctggatcttg aggttggcaa tgttgccgcc tagatcccgt 4320 ctcgggttca tattgtgcag gaccaccaag acagtgtatc cggtgcactt gggaaattta 4380 tcatgcagct tagagggaaa agcatgaaaa aatttggaga cgcctttgtg accccccaga 4440 ttctccatgc actcatccat aatgatagcg atggggccgt gggcagcggc acgggcgaac 4500 acgttccggg ggtctgaaac atcatagtta tgctcctgag tcaggtcatc ataagccatt 4560 ttaataaact ttgggcggag ggtgccagat tgggggatga aagttccctc tggcccggga 4620 gcatagtttc cctcacatat ttgcatttcc caggctttca gttcagaggg ggggatcatg 4680 tccacctgcg gggctataaa aaataccgtt tctggagccg gggtgattaa ctgggacgag 4740 agcaaattcc taagcagctg agacttgccg cacccagtgg gaccgtaaat gaccccaatt 4800 acgggttgca gatggtagtt tagggaacga cagctgccgt cctcccggag caggggggcc 4860 acttcgttca tcatttccct tacatggata ttttcccgca ccaagtccgt taggaggcgc 4920 tctcccccaa gggatagaag ctcctggagc gaggagaagt ttttcagcgg cttcagcccg 4980 tcagccatgg gcattttgga aagagtctgt tgcaagagct cgagccggtc ccagagctcg 5040 gtgatgtgct ctatggcatc tcgatccagc agacctcctc gtttcgcggg ttgggacggc 5100 tcctggagta gggaatcaga cgatgggcgt ccagcgctgc cagggtccga tccttccatg 5160 gtcgcagcgt ccgagtcagg gttgtttccg tcacggtgaa ggggtgcgcg cctggttggg 5220 cgcttgcgag ggtgcgcttc agactcatcc tgctggtcga gaaccgctgc cgattggcgc 5280 cctgcatgtc ggccaggtag cagtttacca tgagttcgta gttgagcgcc tcggccgcgt 5340 ggcctttggc acggagctta cctttggaag ttttatggca ggcggggcag tagatacatt 5400 tgagggcata caacttgggc gcgaggaaaa tggattcggg ggagtatgca tccgcaccgc 5460 aggaggcgca gacggtttcg cactccacga gccaggtcag atccggctca tcggggtcaa 5520 aaacaagttt tccgccatgt tttttgatgc gtttcttacc tttggtttcc atgagttcgt 5580 gtccccgctg ggtgacaaag aggctgtccg tgtccccgta gaccgacttt atgggcctgt 5640 cctcgagcgg agtgcctcgg tcctcttcgt agaggaaccc agcccactct gatacaaaag 5700 cgcgtgtcca ggccagcaca aaggaggcca cgtgggaggg gtagcggtcg ttgtcaacca 5760 gggggtccac cttctctacg gtatgtaaac acatgtcccc ctcctccaca tccaagaatg 5820 tgattggctt gtaagtgtag gccacgtgac caggggtccc cgccgggggg gtataaaagg 5880 gggcgggcct ctgttcgtcc tcactgtctt ccggatcgct gtccaggagc gccagctgtt 5940 ggggtaggta ttccctctcg aaggcgggca tgacctctgc actcaggttg tcagtttcta 6000 ggaacgagga ggatttgata ttgacagtac cagcagagat gcctttcata agactctcgt 6060 ccatctggtc agaaaacaca atcttcttgt tgtccagctt ggtggcaaat gatccataga 6120 gggcattgga tagaagcttg gcgatggagc gcatggtttg gttcttttcc ttgtccgcgc 6180 gctccttggc ggtgatgtta agctggacgt actcgcgcgc cacacatttc cattcaggaa 6240 agatggttgt cagttcatcc ggaactattc tgattcgcca tcccctattg tgcagggtta 6300 tcagatccac actggtggcc acctcgcctc ggaggggctc attggtccag cagagtcgac 6360 ctccttttct tgaacagaaa ggggggaggg ggtctagcat gaactcatca ggggggtccg 6420 catctatggt aaatattccc ggtagcaaat ctttgtcaaa atagctgatg gtggcgggat 6480 catccaaggt catctgccat tctcgaactg ccagcgcgcg ctcatagggg ttaagagggg 6540 tgccccaggg catggggtgg gtgagcgcgg aggcatacat gccacagata tcgtagacat 6600 agaggggctc ttcgaggatg ccgatgtaag tgggataaca tcgcccccct ctgatgcttg 6660 ctcgcacata gtcatagagt tcatgtgagg gggcaagaag acccgggccc agattggtgc 6720 ggttgggttt ttccgccctg taaacgatct ggcgaaagat ggcatgggaa ttggaagaga 6780 tagtaggtct ctggaatatg ttaaaatggg catgaggtaa gcctacagag tcccttatga 6840 agtgggcata tgactcttgc agcttggcta ccagctcggc ggtgatgagt acatccaggg 6900 cacagtagtc gagagtttcc tggatgatgt cataacgcgg ttggcttttc ttttcccaca 6960 gctcgcggtt gagaaggtat tcttcgtgat ccttccagta ctcttcgagg ggaaacccgt 7020 ctttttctgc acggtaagag cccaacatgt agaactgatt gactgccttg tagggacagc 7080 atcccttctc cactgggaga gagtatgctt gggctgcatt gcgcagcgag gtatgagtga 7140 gggcaaaagt gtccctgacc atgactttga ggaattgata cttgaagtcg atgtcatcac 7200 aggccccctg ttcccagagt tggaagtcca cccgcttctt gtaggcgggg ttgggcaaag 7260 cgaaagtaac atcattgaag aggatcttgc cggccctggg catgaaattt cgggtgattt 7320 tgaaaggctg aggaacctct gctcggttat tgataacctg agcggccaag acgatctcat 7380 caaagccatt gatgttgtgc cccactatgt acagttctaa gaatcgaggg gtgcccctga 7440 catgaggcag cttcttgagt tcttcaaaag tgagatctgt agggtcagtg agagcatagt 7500 gttcgagggc ccattcgtgc acgtgagggt tcgctttaag gaaggaggac cagaggtcca 7560 ctgccagtgc tgtttgtaac tggtcccggt actgacgaaa atgctgtccg actgccatct 7620 tttctggggt gacgcaatag aaggtttggg ggtcctgccg ccagcgatcc cacttgagtt 7680 ttatggcgag gtcataggcg atgttgacga gccgctggtc tccagagagt ttcatgacca 7740 gcatgaaggg gattagctgc ttgccaaagg accccatcca ggtgtaggtt tccacatcgt 7800 aggtgagaaa gagcctttct gtgcgaggat gagagccaat cgggaagaac tggatctcct 7860 gccaccagtt ggaggaatgg ctgttgatgt gatggaagta gaactccctg cgacgcgccg 7920 agcattcatg cttgtgcttg tacagacggc cgcagtactc gcagcgattc acgggatgca 7980 ccttatgaat gagttgtacc tgacttcctt tgacgagaaa tttcagtgga aaattgaggc 8040 ctggcgcttg tacctcgcgc tttactatgt tgtctgcatc ggcatgacca tcttctgtct 8100 cgatggtggt catgctgacg agccctcgcg ggaggcaagt ccagacctcg gcgcggcagg 8160 ggcggagctc gaggacgaga gcgcgcaggc cggagctgtc cagggtcctg agacgctgcg 8220 gagtcaggtt agtaggcagt gtcaggagat taacttgcat gatcttttgg agggcgtgag 8280 ggaggttcag atagtacttg atctcaacgg gtccgttggt ggagatgtcg atggcttgca 8340 gggttccgtg tcccttgggc gctaccaccg tgcccttgtt tttcattttg gacggcggtg 8400 gctctgttgc ttcttgcatg tttagaagcg gtgtcgaggg cgcgcaccgg gcggcagggg 8460 cggctcggga cccggcggca tggctggcag tggtacgtcg gcgccgcgcg cgggtaggtt 8520 ctggtactgc gccctgagaa gactcgcatg cgcgacgacg cggcggttga catcctggat 8580 ctgacgcctc tgggtgaaag ctaccggccc cgtgagcttg aacctgaaag agagttcaac 8640 agaatcaatc tcggtatcgt tgacggcggc ttgcctaagg atttcttgca cgtcgccaga 8700 gttgtcctgg taggcgatct cggccatgaa ctgctcgatc tcttcctctt gaagatctcc 8760 gcggcccgct ctctcgacgg tggccgcgag gtcgttggag atgcgcccaa tgagttgaga 8820 gaatgcattc atgcccgcct cgttccagac gcggctgtag accacagccc ccacgggatc 8880 tctcgcgcgc atgaccacct gggcgaggtt gagctccacg tggcgggtga agaccgcata 8940 gttgcatagg cgctggaaaa ggtagttgag tgtggtggcg atgtgctcgg tgacgaagaa 9000 atacatgatc catcgtctca gcggcatctc gctgacatcg cccagcgctt ccaagcgctc 9060 catggcctcg tagaagtcca cggcaaagtt aaaaaactgg gagttacgcg cggacacggt 9120 caactcctct tccagaagac ggataagttc ggcgatggtg gtgcgcacct cgcgctcgaa 9180 agcccctggg atttcttcct caatctcttc ttcttccact aacatctctt cctcttcagg 9240 tggggctgca ggaggagggg gaacgcggcg acgccggcgg cgcacgggca gacggtcgat 9300 gaatctttca atgacctctc cgcggcggcg gcgcatggtc tcggtgacgg cacgaccgtt 9360 ctccctgggt ctcagagtga agacgcctcc gcgcatctcc ctgaagtggt gactgggagg 9420 ctctccgttg ggcagggaca ccgcgctgat tatgcatttt atcaattgcc ccgtaggtac 9480 tccgcgcaag gacctgatcg tctcaagatc cacgggatct gaaaaccttt cgacgaaagc 9540 gtctaaccag tcgcaatcgc aaggtaggct gagcactgtt tcttgcgggc gggggcggct 9600 agacgctcgg tcggggttct ctctttcttc tccttcctcc tcttgggagg gtgagacgat 9660 gctgctggtg atgaaattaa aataggcagt tttgagacgg cggatggtgg cgaggagcac 9720 caggtctttg ggtccggctt gttggatacg caggcgatga gccattcccc aagcattatc 9780 ctgacatctg gccagatctt tatagtagtc ttgcatgagt cgttccacgg gcacttcttc 9840 ttcgcccgct ctgccatgca tgcgagtgat cccgaacccg cgcatgggct ggacaagtgc 9900 caggtccgct acaacccttt cggcgaggat ggcttgctgc acctgggtga gggtggcttg 9960 gaagtcgtca aagtccacga agcggtggta ggccccggtg ttgattgtgt aggagcagtt 10020 ggccatgact gaccagttga ctgtctggtg cccagggcgc acgagctcgg tgtacttgag 10080 gcgcgagtat gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca ggtactggta 10140 gccaatgaga aagtgtggcg gtggctggcg gtacaggggc catcgctctg tagccggggc 10200 tccgggggcg aggtcttcca gcatgaggcg gtggtagccg tagatgtacc tggacatcca 10260 ggtgataccg gaggcggtgg tggatgcacg tgggaactcg cgcacgcggt tccagatgtt 10320 gcgcagcggc atgaagtagt tcatggtagg cacggtctgg ccagtgaggc gcgcgcagtc 10380 attgacgctc tgtagacacg gagaaaacga aagcgatgag cggctcgact ccgtggtctg 10440 ggggaacgtg aacgggttgg gtcgcggtgt accccggttc gagtccaaag ctaagcgatc 10500 acgctcggat cggccggagc cgcggctaac gtggtattgg ctatcccgtc tcgacccagc 10560 cgacgaatat ccagggtacg gagtagagtc gtttttgctg ctttttcctg gacgtgtgcc 10620 attgccacgt caagctttag aacgctcagt tctcgggccg tgagtggctc gcgcccgtag 10680 tctggagaat cagtcgccag ggttgcgttg cggtatgccc cggttggagc ctaagcgcgg 10740 ctcgtatcgg ccggtttccg cgacaagcga gggtttggca gccccgttat ttccaagacc 10800 ccgccagccg acttctccag tttacgggag cgagcccttt tttttttttt tttgtttttg 10860 tcgcccagat gcatccagtg ctgcgacaga tgcgccccca gcaacaggcc ccttctcagc 10920 aacagccaca aaaggctctt cttgctcctg caactactgc agctgcagcc gtgagcggcg 10980 cgggacagcc cgcctatgat ctggacttgg aagagggcga gggattggcg cgcctggggg 11040 ctccatcgcc cgagcggcac ccgcgggtgc aactaaaaaa ggactctcgc gaggcgtacg 11100 tgccccagca gaacctgttc agggacagga gcggcgagga gccagaggag atgcgagcat 11160 ctcgatttaa cgcgggtcgc gagctgcgcc acggtctgga tcgaagacgg gtgctgcaag 11220 acgaggattt tgaggtcgat gaagtcacag ggatcagccc agctagggca catgtggccg 11280 cggccaacct agtctcggcc tacgagcaga ccgtgaagga ggagcgcaac ttccaaaaat 11340 cttttaacaa ccatgtgcgc accctgatcg cccgcgagga agtgaccctg ggtctgatgc 11400 atctgtggga cctgatggag gctatcgccc aaaaccccac tagcaaacca ctgacagctc 11460 agctgtttct ggtggttcaa catagcaggg acaacgaggc attcagggag gcgttgttga 11520 acatcaccga gcctgatggg agatggctgt atgatctgat caacatcctg caaagtatta 11580 tagtgcagga acgtagcctg ggtttggctg agaaagtggc agctatcaac tactcggtct 11640 tgagcctggg caaatactac gctcgcaaga tctacaagac cccctacgta cccatagaca 11700 aggaggtgaa gatagatggg ttttacatgc gcatgactct gaaggtgctg actctgagcg 11760 acgatctggg ggtgtatcgc aatgacagga tgcaccgcgc ggtgagcgcc agcaggaggc 11820 gcgagctgag cgacagagaa cttatgcaca gcttgcaaag agctctaacg ggggccggga 11880 ctgatgggga gaactacttt gacatgggag cggatttgca atggcaaccc agtcgcaggg 11940 ccatggaggc tgcagggtgt gagcttcctt acatagaaga ggtggatgaa gtcgaggacg 12000 aggagggcga gtacttggaa gactgatggc gcgacccgta tttttgctag atggaacagc 12060 agcaggcacc ggaccccgca atgcgggcgg cgctgcagag ccagccgtcc ggcattaact 12120 cctcggacga ttggacccag gccatgcaac gcataatggc gctgacgacc cgcaaccccg 12180 aagcctttag acagcaaccc caggccaacc gcctttctgc catactggag gccgtagtgc 12240 cctcccgctc caaccccacc cacgagaagg tcctggctat cgtgaacgcg ctggtggaga 12300 acaaggccat ccgtcccgat gaggccgggc tggtatacaa tgctctcttg gagcgcgtgg 12360 cccgttacaa cagcagcaac gtgcaaacca acctggaccg gatggtgacc gatgtgcgcg 12420 aggccgtgtc tcagcgcgag cgattccagc gcgacgccaa cttggggtcg ttggtagcgc 12480 taaacgcttt cctcagcacc cagcccgcca acgtgccccg tggtcagcaa gactatacaa 12540 actttttgag tgcattgaga ctcatggtag ctgaggtgcc ccagagcgag gtgtaccagt 12600 ccgggccaga ttacttcttc cagaccagca gacagggctt gcagacagtg aacctgactc 12660 aggctttcaa gaacctgaag ggtctgtggg gagtgcacgc cccagtaggg gatcgcgcga 12720 ccgtgtctag cttgctgact cccaactccc gcctgctgct gctgctggta tcccccttta 12780 ctgacagcgg tagcattgac cgcaactcgt acttgggcta cctgcttaac ctgtatcgcg 12840 aggccatagg acagagccag gtggacgagc agacctatca agaaatcacc caagtgagcc 12900 gcgccctggg tcaggaagac acgggcagtt tggaagccac cctgaacttc ttgctaacca 12960 accggtcaca gaagatccct cctcagtatg cgcttaccgc tgaggaggag cggatcctca 13020 gatacgtgca acagagcgtt ggactgttcc tgatgcagga gggggcgaca cctaccgccg 13080 cgctggacat gacagctcga aacatggagc ccagcatgta tgctagtaac aggcctttca 13140 ttaacaaact gctggactac ctgcacaggg cggccgccat gaactctgat tatttcacca 13200 atgctatcct gaacccacac tggctgcccc cacctggttt ctacactggc gagtacgaca 13260 tgcccgaccc caatgacggg ttcctgtggg acgatgtgga cagcagcata ttttccccgc 13320 ctcccggtta tacagtttgg aagaaggaag ggggcgatag aagacactct tccgtgtcgc 13380 tatccggaac ggctggtgct gccgcgaccg tgcccgaagc tgcaagtcct ttccctagct 13440 tgcccttttc actaaacagc gttcgcagca gtgaactggg gagaataacc cgcccgcgct 13500 tgatgggcga ggatgagtac ttgaatgact ctttgctgag gccagagagg gaaaagaact 13560 tccccaacaa tggaatagag agtctggtgg ataagatgag tagatggaag acctatgcgc 13620 aggatcacag agacgagccc aggatcttgg gggctacaag cagaccgatc cgtagacgcc 13680 agcgccacga caggcagatg ggtcttgtgt gggacgatga ggactctgcc gatgatagca 13740 gcgtgttgga cttgggtgga agaggagggg gcaacccgtt cgctcatctg cgtcccagat 13800 tcgggcgcat gttgtaaaag tgaaagtaaa ataaaaaggc aactcaccaa ggccatggcg 13860 accgagcgtg cgttcgttct tttttgttat ctgtgtctag tacgatgagg agacgagccg 13920 tgctaggcgg agcggtggtg tatccggagg gtcctcctcc ttcttacgag agcgtgatgc 13980 agcaacaggc ggcgatgata cagcccccac tggaggctcc cttcgtaccc ccacggtacc 14040 tggcgcctac ggaagggaga aacagcattc gttactcgga gctgtcgccc ctgtacgata 14100 ccaccaagtt gtatctggtg gacaacaagt cggcggacat cgcctccctg aactatcaga 14160 acgaccacag caacttcctg accacggtgg tgcagaacaa tgactttacc cccacggagg 14220 ctagcaccca gaccatcaac tttgacgagc ggtcgcgatg gggcggtcag ctgaagacca 14280 tcatgcacac caacatgccc aacgtgaacg agtacatgtt cagcaacaag ttcaaggcga 14340 gggtgatggt gtccagaaaa gctcctgaag gtgttacagt aaatgacacc tatgatcata 14400 aagaggatat cttgaagtat gagtggtttg agttcatttt accagaaggc aacttttcag 14460 ccaccatgac gatcgacctg atgaacaatg ccatcattga caactacctg gaaattggca 14520 gacagaatgg agtgctggaa agtgacattg gtgttaagtt tgacactaga aatttcaggc 14580 tcgggtggga ccccgaaact aagttgatta tgccaggtgt ctacacttat gaggcattcc 14640 atcctgacat tgtattgctg cctggttgcg gggtagactt tactgaaagc cgacttagca 14700 acttgcttgg catcaggaag agacatccat tccaggaggg tttcaaaatc atgtatgaag 14760 atcttgaagg gggtaatatt cctgcccttt tggatgtcac tgcctatgag gaaagcaaaa 14820 aggataccac tactgaaaca accacactgg ctgttgcaga ggaaactagt gaagatgatg 14880 atataactag aggagatacc tatataactg aaaaacaaaa acgtgaagct gcagctgctg 14940 aagttaaaaa agagttaaag atccaacctc tagaaaaaga cagcaagagt agaagctaca 15000 atgtcttgga agacaaaatc aacacagcct accgcagttg gtacctgtcc tacaattacg 15060 gtaaccctga gaaaggaata aggtcttgga cactgctcac cacttcagat gtcacctgtg 15120 gggcagagca ggtctactgg tcgctccctg acatgatgca agacccagtc accttccgct 15180 ccacaagaca agtcaacaac tacccagtgg tgggtgcaga gcttatgccc gtcttctcaa 15240 agagtttcta caatgagcaa gccgtgtact ctcagcagct ccgacaggcc acttcgctca 15300 cgcacgtctt caaccgcttc cctgagaacc agatcctcat ccgcccgccg gcgcccacaa 15360 ttaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggaccctg ccgttacgca 15420 gcagtatccg gggagtccag cgcgtgaccg ttactgacgc cagacgccgc acctgtccct 15480 acgtttacaa ggccctgggc atagtcgcgc cgcgcgttct ttcaagccgc actttctaaa 15540 aaaaaaaaaa atgtccattc tcatctcgcc cagtaataat accggttggg gactgtatgc 15600 gcccaccaag atgtatggag gcgcccgcaa gcgctctacc cagcatcctg tgcgcgttcg 15660 cggtcatttc cgcgctccct ggggcgcact caagggtcgt acccgcactc ggaccacggt 15720 cgatgatgtg atcgaccagg tggtcgccga tgctcgtaat tatactccta ctgcgcctac 15780 atctactgtg gatgcagtta ttgacagtgt ggtggcagac gcccgcgcct atgctcgccg 15840 gaagagccga aggaggcgca tcgccaggcg ccacagggct actcccgcca tgcgagccgc 15900 aaaagctatt ctgcggaggg ccaaacgtgt ggggcgaaga gccatgctta gagcggccag 15960 acgcgcggct tcaggtgcca gcagcggcag gtcccgcagg cgcgcggcca cggcggcagc 16020 agcggccatt gccaacatgg cccaaccgcg aagaggcaat gtgtactggg tgcgtgatgc 16080 cactaccggc cagcgcgtgc ccgtgcgcac ccgcccccct cgcacttaga agatactgag 16140 cagtctccga tgttgtgtcc cagcggcaag tatgtccaag cgcaaataca aggaagagat 16200 gctccaggtc atcgcgcctg aaatctacgg tccgccggtg aaggatgaaa aaaagccccg 16260 caaaatcaag cgggtcaaaa ataacaaaaa ggaagaagat gacgatgatg ggctggtgga 16320 gtttgtgcgc gagttcgccc caagacggcg cgtgcagtgg cgcgggcgca aagtgcgtca 16380 agtgctcaga cccgggacca ctgtggtttt tacacctggc gagcgttcca gcactacttt 16440 taaacggtcc tatgatgagg tgtacgggga tgacgatatt cttgagcagg cggcagaccg 16500 ccttgacgag tttgcttatg gcaagcgcac tagatccagt cccaaagagg aggctgtgtc 16560 cattcctttg gatcatggaa atcccacccc cagcctcaaa ccagtcaccc tgcagcaagt 16620 gctgcccgtg cctgcgcgga gaggcgtaaa gcgcgagggt gaggacctat atcccaccat 16680 gcagctaatg gtgcccaagc gccagaggct agaagacgta ctggagaaaa tgaaagtgga 16740 tgccgatatc cagcctgagg tcaaagtaag acctatcaag gaagtggcgc caggtttggg 16800 agtacaaacc ttcgacatca agattcccac cgagtccatg gaagtgcaga ccgaacctgc 16860 aaaacccacc acctcaattg aggtgcaaac ggaaccctgg atgcccgcgc ccgttgccgc 16920 ccccagcacc actcgaagat cacgacgaaa gtacggccca gcaagtctgc taatgcccaa 16980 ctatgctctg cacccatcca tcattcccac tccgggttac agaggcactc gctactatcg 17040 aaaccggagc aacacctctc gccgccgcaa accacctgca agtcgcactc gccgtcgccg 17100 ccgccgcaac actgccagca aattgactcc cgccgccctg gtgcggagag tgtaccgcga 17160 tggtcgcgct gaacctctga cgctgccgcg cgcgcgctac catccaagca tcaccactta 17220 atgactgttg acgctgcctc cttgcagata tggccctcac ttgccgcctt cgcgtcccca 17280 ttactggcta ccgaggaaga aactcgcgcc gtagaaggat gttggggcga gggatgcgcc 17340 gccacagacg aaggcgcgct atcagcagac gattaggggg tggctttttg ccagctctta 17400 tacccatcat cgccgcagcg atcggggcga taccaggcat agcttcagtg gcggttcagg 17460 cctcgcagcg ccactaacat tggaaaaaac ttataaataa aaaatagaat ggactctgac 17520 gctcctggtc ctgtgactat gtttttgtag agatggaaga catcaatttt tcatccctgg 17580 ctccgcgaca cggcacgagg ccgtacatgg gcacctggag cgacatcggc acgagccaac 17640 tgaacggggg cgccttcaat tggagcagta tctggagcgg gcttaaaaat tttggctcga 17700 ccgtaaaaac ctatgggaac aaagcttgga acagcagcac agggcaggct ctgagaaata 17760 agcttaagga acaaaacttc caacagaagg tggtcgatgg gatcgcctct ggtattaacg 17820 gcgtagtgga tctggccaac caggctgtac aaaaacagat aaacagccgc ctggacccgc 17880 cgcccgcaac ccctggtgaa atggaagtgg aggaagaact tcctccgctg gaaaagcggg 17940 gcgacaagcg tccgcgaccc gagctagagc agacgctggt gacgcgcgca gacgagcccc 18000 cttcatatga ggaggcagta aagctcggaa tgcccactac caggcctgta gctcacatgg 18060 ctaccggggt gatgaaacct tctcagtcac atcgacccgc caccttggac ttgcctcctc 18120 cccctgcttc tgcggcgcct gttcccaaac ctgtcgctac cagaaagccc accgccgtac 18180 agcccgtcgc cgtagccaga ccgcgtcctg ggggcacacc gcgcccgaaa gcaaactggc 18240 aaagtactct gaacagcatc gtgggtctgg gcgtgcagag tgtaaagcgc cgtcgctgct 18300 attaattaaa tatggagtag cgcttaactt gcttgtctgt gtgtatgtat catcaccacg 18360 ccgccgcagc agaggagaaa ggaagaggtc gcgcgccgag gctgagttgc tttcaagatg 18420 gccaccccat cgatgatgcc ccaatgggca tacatgcaca tcgccggaca ggatgcttcg 18480 gagtacctca gtccgggtct ggtgcagttc gcccgtgcaa cagacaccta cttcagtatg 18540 gggaacaaat ttagaaaccc cacagtggcg cccacccacg atgtgaccac cgaccgtagc 18600 cagcgcctga tgctgcgctt cgtgcccgtt gaccgggaag acaataccta ctcttacaaa 18660 gttcgctaca cgctggctgt aggcgacaac agagtgcttg acatggccag cacattcttt 18720 gacattcggg gggtgcttga tagaggtcct agcttcaagc catattccgg cacagcttac 18780 aattcactcg ctcctaaggg cgcgcccaat acatctcagt ggatagttac aacaaatggg 18840 gacaatgcag taactaccac cacaaacaca tttggcattg cttccatgaa gggagacaat 18900 attactaaag aaggtttgca aattgggaaa gacattacca ctactgaagg agaagaaaag 18960 cccatttatg ccgataaaac atatcagcca gagcctcaag ttggagaaga atcatggact 19020 gatactgatg gaacaaatga aaagtttggt ggaagagccc ttaaaccagc taccaacatg 19080 aagccatgct acgggtcttt tgcaagacct acaaacataa aagggggcca agctaaaaac 19140 agaaaagtaa aaccaacaac cgaaggaggg gttgaaactg aggaaccaga tattgatatg 19200 gaatttttcg atggtagaga tgctgttgca ggagctttag cgcctgaaat tgtgctttat 19260 acggaaaatg taaatttgga aactccagac agtcatgtgg tatataaacc agaaacgtct 19320 aataactctc atgcaaattt gggtcaacaa gccatgccta acagacccaa ttacattggc 19380 ttcagggata acttcgtagg cctaatgtac tacaacagta ctggaaatat gggagttttg 19440 gctggccaag catcacaact gaatgcagtg gttgacttgc aggacagaaa tactgaactg 19500 tcatatcagc ttttgcttga ttctctggga gacagaacca gatacttcag catgtggaat 19560 caggctgtgg acagttacga tcccgatgtt cgcattattg aaaatcatgg catcgaggat 19620 gaactgccta attactgttt tcctctgaat ggcataggac cagggcacac atatcaaggc 19680 attaaagtta aaaccgatga cactaatgga tgggaaaaag atgctaatgt tgctccagct 19740 aatgaaataa ccataggcaa caacctggct atggaaatta atatccaagc taacctttgg 19800 agaagttttc tgtactctaa tgtggctttg taccttccag atgtttacaa gtacacgcca 19860 cctaacatta ctttgcccac taacaccaac acctatgagt acatgaacgg gcgagtggta 19920 tccccatccc tggttgattc atacatcaac attggcgcca ggtggtctct tgacccaatg 19980 gacaatgtga atccattcaa ccaccaccgc aatgctggtc tgcgctacag gtccatgctt 20040 ctgggaaatg gtcgttatgt gcctttccac atacaagtgc ctcagaaatt ctttgctgtc 20100 aagaacctac ttcttctacc tggctcctac acctacgagt ggaacttccg aaaggatgtg 20160 aacatggtcc tgcaaagttc ccttggaaat gacctcagaa cggatggtgc taccataagt 20220 ttcaccagca tcaatctcta tgccaccttc ttccccatgg ctcacaacac agcttccacc 20280 cttgaagcca tgctgcgcaa cgataccaat gatcagtcat ttaacgacta cctctctgca 20340 gctaacatgc tttaccccat tcctgccaat gcaaccaaca ttccaatttc catcccatct 20400 cgcaactggg cagccttcag gggctggtcc ttcaccagac tcaaaaccaa ggagactcca 20460 tctcttggat cagggttcga tccctacttc gtatattctg gatctattcc ctacctggat 20520 ggcacctttt accttaacca cactttcaag aaggtctcca tcatgtttga ctcctcagtc 20580 agctggcctg gcaatgacag gctgttgagt ccaaatgagt ttgaaatcaa gcgcactgtg 20640 gacggggaag gatacaacgt ggcacaatgc aacatgacca aagactggtt cctggttcag 20700 atgcttgcca attacaacat tggctaccag ggcttttaca tccctgaggg atacaaggat 20760 cgcatgtact cctttttcag aaacttccag cctatgagca ggcaggtggt tgatgaggtt 20820 aattacactg actacaaagc cgtcacctta ccataccaac acaacaactc tggctttgta 20880 gggtaccttg cacctactat gagacaaggg gaaccttacc cagccaatta tccatacccg 20940 ctcatcggaa ctactgccgt taagagtgtc acccagaaaa agttcctgtg cgacaggacc 21000 atgtggcgca ttcccttctc cagcaacttc atgtccatgg gggcccttac cgacctggga 21060 cagaacatgc tctatgccaa ctcagcccat gcgctggaca tgacttttga ggtggatccc 21120 atggatgagc ccaccctgct ttatcttctt ttcgaagtct tcgacgtggt cagagtgcac 21180 cagccacacc gcggcgtcat cgaggccgtc tacctgcgca caccgttctc ggccggcaac 21240 gccaccacat aagaagcctc ttgcttcttg caagcagcag ctgcagccat gacatgcggg 21300 tccggaaacg gctccagcga gcaagagctc aaagccatcg tccgagacct gggctgcgga 21360 ccctatttcc tgggaacctt tgacaagcgt ttcccggggt tcatggcccc cgacaagctc 21420 gcctgcgcca tagtcaacac tgccggacgc gagacggggg gagagcactg gctggctttt 21480 ggttggaacc cgcgctacaa cacctgctac ctttttgatc cttttgggtt ctcggatgag 21540 cggctcaaac agatttacca gtttgagtac gaggggctcc tgcgtcgcag tgcccttgct 21600 accaaagacc gctgcatcac cctggagaag tctacccaaa gcgtgcaggg tccgcgctca 21660 gccgcctgtg gacttttttg ctgtatgttc cttcatgcct ttgtgcactg gcccgaccgc 21720 cccatggacg gaaaccccac catgaagttg ctgactgggg tgtccaacag catgctccaa 21780 tcaccccaag tccagcccac cctgcgccgc aaccaggagg tgctataccg cttcctaaac 21840 acccactcat cttactttcg ttctcaccgc gcgcgcattg aaagggccac cgcgtttgac 21900 cgtatggata tgcaataagt catgtaaaac cgtgttcaat aaacagcact ttatttttac 21960 atgcactgag gctctggttt tgctcatttg tttcatcatt tactcagaag tcgaatgggt 22020 tctggcggga gtcagagtga cccgcgggca gggatacgtt gcggaactgt aacctgttct 22080 gccacttgaa ctcggggatt accagcttgg gaactggaat ctcgggaaag gtgtcttgcc 22140 acaactttct ggtcagttgc atagcgccaa gcaggtcagg agcagagatc ttgaaatcac 22200 agttggggcc ggcattctgg acacgggagt tgcgatacac tgggttgcaa cactggaaca 22260 ctatcaacgc tgggtgtctt acgcttgcca acacggttgg gtcactgatg gtagtcacat 22320 ccaagtcttc agcattggcc atcccaaagg gggtcatctt acatgtctgc ctgcccatca 22380 cgggagcgca gcctggcttg tggttgcaat cacaatgaat ggggatcagc atcatcctgg 22440 cttggtcggg agttatccct gggtacacag ccttcatgaa ggcttcgtac tgcttaaaag 22500 cttcctgggc cttacttccc tcggtgtaga acatcccaca ggacttgctg gaaaattgat 22560 tagtagtaca gttggcatca ttcacacaac agcgggcatc gttgttggcc aactgaacca 22620 catttctgcc ccagcggttt tgggtgatct tggctctgtc tggattctcc ttcatagcgc 22680 gctgcccgtt ctcgctcgcc acatccatct cgataatgtg gtccttctgg atcatgatag 22740 tgccatgcag gcatttcacc ttgccttcat aatcggtgca tccatgagcc cacagagcgc 22800 acccggtgca ctcccaatta ttgtgggcga tctcagaata ataatgtacc aatccctgca 22860 tgaatcttcc catcattgtt gtcaaggtct tcatgctggt aaatgtcagc gggatgccac 22920 ggtgctcctc gttcacatac tggtggcaga tacgcttgta ttgctcgtgc tgctctggca 22980 tcagcttgaa agaggttctc agatcattat ccagcctgta cctttccatt agcacagcca 23040 tcacttccat gcccttctcc caggcagata ccaggggcag actcaaagga ttcctaacag 23100 caataaaagt agctccttta gctatagggt cattcttgtc gatcttctca acacttctct 23160 tgccatcctt ctcaatgatg cgcaccgggg ggtagctgaa gcccacggcc accaactgag 23220 cctgttctct ttcttcttca ctatcctggc tgatgtcttg cagagggaca tgcttggtct 23280 tcctgggctt cttcttggga gggatcgggg gaggactgtt gctccgctcc ggagacaggg 23340 atgactgcga agtttcgctt accaatacca cctggctctc ggtagaagaa ccggacccca 23400 cacgacggta ggtgttcctc ttcgggggca gaggtggagg cgactgagat gggctgcggt 23460 ctggccttgg aggcggatgg ctggcagagc tcattccgcg ttcgggggtg tgctcccggt 23520 ggcggtcgct tgactgattt cctccgcggc tggccattgt gttctcctag gcagagaaac 23580 aacagacatg gaaactcagc catcactgcc aacatcgctg caagcaccat cacacctcgc 23640 ccccagcagc gacgaggagg agagcttaac caccccacca cccagtcccg ctaccaccac 23700 ctctaccctc gatgatgagg aggaggtcga cgcagcccag gagatgcagg cgcaggataa 23760 tgtgaaaacg gaagagattg aggcagatgt cgagcaggac ccgggctatg tgacgccggc 23820 ggagcaccag gaggagctga aacgctttct agacagagag gatgacgacc gcccagagca 23880 tcaagcagat ggcgtttacc aggaggctgg gatcagggat catgtcgccg actacctcac 23940 cggccttggt ggggaggacg tgctcctcaa acatctagca aggcagtcga tcatagttaa 24000 agacgcattg ctcgatctca ctgaagtgcc catcagtgtg gaagagctta gccgcgccta 24060 cgagctgaac ctcttttcgc ctcaggtacc ccccaagcgg cagccaaacg gcacctgcga 24120 ggccaaccct cgactcaact tctatccagc ttttactatc cccgaagtgt tggccaccta 24180 ccacatcttt ttcaagaacc aaaagattcc agtctcctgc cgcgccaacc gcacccgcgc 24240 cgatgccctg ctcaacttgg gtccgggagc tcgcttacct gatatagctt ccttggaaga 24300 ggttccaaag atctttgagg gtctgggaag tgatgagaca cgggccgcaa atgctctgca 24360 acagggagag aatgacatgg atgaacacca cagcgctctg gtggaactgg agggtgacaa 24420 tgcccggatt gcagtgctca agcgcagtat cgtggtcacc cattttgcct accccgctgt 24480 taacctgccc cccaaagtta tgagcgctgt catggaccat ctgctcatca aacgagcaag 24540 acctctttca gaaaaccaga acatgcagga tccagacgcc tcggacgagg gcaagccggt 24600 agtcagtgac gagcagctat ctcgctggct gggtaccaac tccccccgag atttggaaga 24660 gaggcgcaag cttatgatgg ctgtagtgct agtaactgtg gagctggagt gtctgcgccg 24720 ctttttcacc gaccctgaga ccctgcgcaa gctagaggag aacctgcact acacctttag 24780 acatggcttc gtgcggcagg catgcaagat ctccaacgtg gagcttacca acctggtttc 24840 ttacatgggc attttgcatg agaaccgact agggcagagc gtcctgcaca ccacccttaa 24900 aggggaggcc cgccgtgact acatccgaga ctgtgtctac ctctacctct gccatacctg 24960 gcaaactggt atgggtgtgt ggcaacagtg tttggaagag cagaacctaa aagagctgga 25020 caagctcttg cagagatccc tcaaagccct gtggacaggt tttgatgagc gcaccgtcgc 25080 ctcggacctg gcagacatca tcttccccga gcgtctcagg gttactctgc gaaacggcct 25140 gccagacttt atgagccaga gcatgcttaa caactttcgc tctttcatcc tggaacgctc 25200 cggtatcctg cctgccacct gctgtgcgct gccctccgac tttgtgcctc tcacctaccg 25260 cgagtgccca ccgccgctat ggagccactg ctacctgttc cgcctggcca actacctctc 25320 ctaccactcg gatgttatag aggatgtgag cggagacggc ctgctggaat gccactgccg 25380 ctgcaatctt tgcacacccc accgctccct tgcctgcaac ccccagttgc tgagcgagac 25440 ccagattatc ggcaccttcg agctgcaggg tcccagaagt aaaggcgagg ggtcttctcc 25500 ggggcagagt ttgaaactga caccggggct gtggacctcc gcctacctgc gcaagtttca 25560 ccccgaggac taccatccct atgagatcag gttctatgag gaccaatcac atcctcccaa 25620 agtcgagctc tcagcctgcg tcatcaccca gggagcaatt ctggcccaat tgcaagccat 25680 ccaaaaatct cgccaagaat ttctgctaaa aaagggaaac ggggtctacc ttgaccctca 25740 gaccggtgag gagctcaaca caaggttccc ccaggatgtc ccatcgccga ggaagcaaga 25800 agttgaaggt gcagctgtcg cccccagagg atatgaagga agactgggac agtcaggcag 25860 aggaggagat ggaagattgg gacagccagg cagaggaggt ggacagcctg gaggaagaca 25920 gtttggagga ggaagacgag gaggcagagg aggtggaaga agcaaccgcc gccaaacagt 25980 tgtcatcggc ggcggagaca agcaagtccc cagacagcag cacggctacc atctccgctc 26040 cgggtcgggg ggcccagcgg cggcccaaca gtagatggga cgagaccggg cgattcccaa 26100 acccgaccac cgcttccaag accggtaaga aggagcgaca gggatacaag tcctggcgtg 26160 gacataaaaa cgctatcatc tcctgcttgc atgaatgcgg gggcaacata tccttcaccc 26220 ggcgatacct gctcttccac cacggtgtaa acttcccccg caatatcttg cattactacc 26280 gtcacctcca cagcccctac tgcagtcagc aagtcccggc aaccccgaca gaaaaataca 26340 gcagcgacaa cggtgaccag aaaaccagca gttagaaaat ccacaacaag tgcaccagga 26400 ggaggactga ggatcacagc gaacgagcca gcgcagacca gagagctgag gaaccggatc 26460 tttccaaccc tctatgccat tttccagcag agtcgggggc aagagcagga actgaaagta 26520 aaaaaccgat ctctgcgctc gctcaccaga agttgtttgt atcacaagag cgaagaccaa 26580 cttcagcgca ctctcgagga cgccgaggct ctcttcaaca agtactgcgc gctgactctt 26640 aaagagtagc ccttgcccgc gctcattttg aaaacggcgg gaatcacgtc acccttggca 26700 cctgtccttt gcccttgtca tgagtaaaga gattcccacg ccttacatgt ggagctatca 26760 gccccaaatg gggttggcag caggcgcttc ccaggactac tccacccgca tgaattggct 26820 tagcgccggg ccctcaatga tatcacgggt taatgatata cgagcttatc gaaaccagtt 26880 actcctagaa cagtcagctc tcaccaccac accccgtcaa caccttaatc cccgaaattg 26940 gcccgccacc ctggtgtacc aggaaaatcc cgctcccacc accgtactac ttcctcgaga 27000 cgcccaggcc gaagttcaga tgactaacgc aggtgtacag ctggcgggcg gttccgccct 27060 atgtcgtcac cgacctcaac agagtataaa acgcctggtg attagaggcc gaggtatcca 27120 gctcaacgac gagtcggtta gctcttcgct tggtctgcga ccagacggag tcttccaaat 27180 cgccggctgt gggagatctt ccttcactcc tcgtcaggct gtgctgactt tggagagttc 27240 gtcctcgcag ccccgctcgg gcggcattgg aactctccag tttgtggagg agtttactcc 27300 ctctgtctac ttcaacccct tctccggctc tcctggccag tacccggacg agttcatacc 27360 aaacttcgac gcaatcagcg agtcagtgga tggctatgat tgatgtctaa tggtggtgcg 27420 gctgagctag ctcgactgcg acacctagac cactgccgcc gctttcgctg cttcgcccgg 27480 gaactcaccg agttcatcta cttcgaactc tccgaggagc accctcaggg tccggcccac 27540 ggagtgcgga ttaccatcga agggggaata gactctcgcc tgcatcgcat cttctcccag 27600 cggcccgtgc taattgaacg cgaccaggga aatacaacca tctccatcta ctgcatctgt 27660 aaccaccccg gattgcatga aagcctttgc tgtcttgttt gtgctgagtt taataaaaac 27720 tgagttaaga ccctcctacg gactaccgct tcttcaatca ggactttaca acaccaacca 27780 gatcttccag aagacccaga cccttcctcc tttcatccag gactctaact ctaccttacc 27840 agcaccctcc actactaacc ttcccgaaac aaacaagctt gcatctcatc tgcaacaccg 27900 cctttcacga agccttcttt ctgccaatac taccactccc aaaaccggag gtgagctccg 27960 cggtcttcct actgacgacc cctgggtggt agcgggtttt gtaacgttag gagtagttgc 28020 gggtgggctt gtgctgatcc tttgctacct atacacacct tgctgtgcat atttagtcat 28080 attgtgctgt tggtttaaga aatgggggcc atactagtcg tgcttgcttt actttcgctt 28140 ttgggtctgg gctctgctaa tctcaatcct ctcgatcacg atccatgttt agacttcgac 28200 ccagaaaact gcacacttac ttttgcaccc gacacaagcc gtctctgtgg agttcttatt 28260 aagtgcggat gggactgcag gtccgttgaa attacacata ataacaaaac atggaacaat 28320 accttatcca ccacatggga gccaggagtt ccccagtggt atactgtctc tgtccgaggt 28380 cctgacggtt ccatccgcat tagtaacaac actttcattt tttctgaaat gtgcgatctg 28440 gccatgttca tgagcagaca gtatgaccta tggcctccca gcaaagagaa cattgtggca 28500 ttttccattg cttattgctt ggtaacatgc atcatcactg ctatcatttg tgtgtgcata 28560 cacttgctta tagttattcg ccctagacaa agcaatgagg aaaaagagaa aatgccttaa 28620 cctttttcct catacctttt ctttacagca tggcttctgt tacagctcta attattgcca 28680 gcattgtcac tgtcgctcac gggcaaacaa ttgtccatat taccttagga cataatcaca 28740 ctcttgtagg gcccccaatt acttcagagg ttatttggac caaacttgga agtgttgatt 28800 attttgatat aatttgcaac aaaactaaac caatatttgt aatctgtaac agacaaaatc 28860 tcacgttaat taatgttagc aaaatttata acggttacta ttatggttat gacagatcca 28920 gtagtcaata taaaaattac ttagttcgca taactcagcc caaattaaca gtgccaacta 28980 tgacaataat taaaatggct aataaagcat tagaaaattt tacatcacca acaacaccca 29040 atgaaaaaaa cattccaaat tcaatgattg caattattgc ggcggtggca ttgggaatgg 29100 cactaataat aatatgcatg ctcctatatg cttgttacta taaaaagttt caacataaac 29160 aggatccact actaaatttt aacatttaat tttttataca gatgatttcc actacaattt 29220 ttatcattac tagccttgca gctgtaactt atggccgttc acacctaact gtacctgttg 29280 gctcaacatg tacactacaa ggaccccaag aaggctatgt cacttggtgg agaatatatg 29340 ataatggagg gttcgctaga ccatgtgatc agcctggtac aaaattttca tgcaacggaa 29400 gagacttgac cattattaac ataacatcaa atgagcaagg cttctattat ggaaccaact 29460 ataaaaatag tttagattac aacattattg tagtgccagc caccacttct gctccccgca 29520 aatccacttt ctctagcagc agtgccaaag caagcacaat tcctaaaaca gcttctgcta 29580 tgttaaagct tccaaaaatc gctttaagta attccacagc cgctcccaat acaattccta 29640 aatcaacaat tggcatcatt actgccgtgg tagtgggatt aatgattata tttttgtgta 29700 taatgtacta cgcctgctgc tatagaaaac atgaacaaaa aggtgatgca ttactaaatt 29760 ttgatattta attttttata gaattatgat attgtttcaa tcaaatacca ctacctccta 29820 tgcatacaca aacattcagc ctaaatacgc tatgcaacta gaaatcacaa tactaattgt 29880 aattggaatt cttatactat ctgttattct ttattttata ttctgccgtc aaatacccaa 29940 tgttcataga aattctaaaa gacgtcccat ctattctcct atgattagtc gtccccatat 30000 ggctctgaat gaaatctaag atcttttttt ttttctctta cagtatggtg aacatcaatc 30060 atgatcccta gaaatttctt cttcaccata ctcatctgtg cttttaatgt ctgtgctact 30120 ttcacagcag tagccactgc aagcccagac tgtataggac catttgcttc ctatgcactt 30180 tttgccttcg ttacttgcat ctgcgtgtgt agcatagtct gcctggttat taattttttc 30240 caactggtag actggatctt tgtgcgaatt gcctacctac gtcaccatcc cgaataccgc 30300 aatcaaaatg ttgcggcact tcttaggctt atttaaaacc atgcaggcta tgctaccagt 30360 cattttaatt ttgctactac cctgcattcc cctagcttcc accgccactc gcgctacacc 30420 tgaacaactt agaaaatgca aatttcaaca accatggtca tttcttgatt gctaccatga 30480 aaaatctgat tttcccacat actggatagt gattgttgga ataattaaca tactttcatg 30540 tacctttttc tcaatcacaa tataccccac atttaatttt gggtggaatt ctcccaatgc 30600 actgggttac ccacaagaac cagatgaaca tattccacta caacacatac aacaaccact 30660 agcactggta cagtatgaaa atgagccaca accttcactg ccccctgcca ttagttactt 30720 caacctaacc ggcggagatg actgacccaa tcgccacatc atccaccgct gccaaggagc 30780 tgctggacat ggacggacgt gcctcagaac agcgactcat ccaactacgc attcgtcagc 30840 agcaggaacg agcagtaaaa gagctaaggg atgccattgg gattcaccag tgcaaaaaag 30900 gcatattctg cttagtaaaa caatccaaaa tctcctacga gatcaccgct actgaccatc 30960 gtctctcata cgagctcggt ccgcagcgac aaaaattcac ctgcatggtg ggaatcaacc 31020 ccatagttat cacccagcag tctggagata ctaagggttg tatccagtgt tcctgtgatt 31080 ccaccgagtg catctacaca ctgctgaaga ccctctgcgg ccttcgagac ctcctaccca 31140 tgaactaatc attgccccta ccttacccaa tcaaaatatt aataaagaca cttacttgaa 31200 atcagcaata cagtctttgt caaaactttc taccagcagc acctcaccct cttcccaact 31260 ctggtactct aaacgtcgga gggtggcata ctttctccac actttgaaag ggatgtcaaa 31320 ttttatttcc tcttctttgc ccacaatctt catttcttta tccccagatg gccaagcgag 31380 ctcggctaag cacttccttc aacccggtgt acccttatga agatgaaagc agctcacaac 31440 acccatttat aaatcctggt ttcatttccc ctgacgggtt cacacaaagt ccaaacgggg 31500 ttttaagtct taaatgtgtt aatccactta ccactgcaag cggctccctc caacttaaag 31560 tgggaagtgg tcttacagta gacactactg atggatcctt agaagaaaac atcaaagtta 31620 acacccccct aacaaagtca aaccattcta taaatttacc aataggaaac ggtttgcaaa 31680 tagaacaaaa caaactttgc agtaaactcg gaaatggtct tacatttgac tcttccaatt 31740 ctattgcact gaaaaataac actttatgga caggtccaaa accagaagcc aactgcataa 31800 ttgaatacgg gaaacaaaac ccagatagca aactaacttt aatccttgta aaaaatggag 31860 gaattgttaa tggatatgta acgctaatgg gagcctcaga ctacgttaac accttattta 31920 aaaacaaaaa tgtctccatt aatgtagaac tatactttga tgccactggt catatattac 31980 cagactcatc ttctcttaaa acagatctag aactaaaata caagcaaacc gctgacttta 32040 gtgcaagagg ttttatgcca agtactacag cgtatccatt tgtccttcct aatgcgggaa 32100 cacataatga aaattatatt tttggtcaat gctactacaa agcaagcgat ggtgcccttt 32160 ttccgttgga agttactgtt atgcttaata aacgcctgcc agatagtcgc acatcctatg 32220 ttatgacttt tttatggtcc ttgaatgctg gtctagctcc agaaactact caggcaaccc 32280 tcataacctc cccatttacc ttttcctata ttagagaaga tgactgacaa caaaaataaa 32340 gttcaacatt ttttattgaa attcctttta cagtattcga gtagttattt tgcctccccc 32400 ttcccattta acagaataca ccaatctctc cccacgcaca gctttaaaca tttggatacc 32460 attagagata gacatagttt tagattccac attccaaaca gtttcagagc gagccaatct 32520 ggggtcagta atacataaaa atgcatcggg atagtctttt aaagcgcttt cacagtccaa 32580 ctgttgcgga tgcgactccg gagtctgaat cacggtcatc tggaagaaga acgatgggaa 32640 tcataatccg aaaacggaat cgggcgattg tgtctcatca aacccacaag caaccgctgt 32700 ctgcgtcgct ccgtgcgact gctgtttatg ggatcggggt ccgcagtgtc ctgaagcatg 32760 attttaatag cccttaacat taactttctg gtgcgatgcg cgcagcaacg cattctgatt 32820 tcacttagat tactacagta ggtacagcac attatcacaa tattgtttaa taaaccataa 32880 ttaaaagcgc tccagccaaa actcatatct gatataatcg cccctgcatg accatcatac 32940 caaagtttaa tataaattaa atgtcgttcc ctcaaaaaca cactacccac atacatgatc 33000 tcttttggca tgtgcatatt aacaatttgt ctgtaccatg gacaacgttg gttaatcatg 33060 caacccaata taaccttccg gaaccacact gccaacaccg ctcccccagc catgcattga 33120 agtgaaccct gctgattaca atgacaatga agaacccaat tctctcgacc atgaatcact 33180 tgagactgaa aaatatctat agtagcacaa caaagacata aatgcatgca tcttctcata 33240 atttttaact cctctggatt taaaaacata tcccaaggaa tgggaaactc ttgcagaaca 33300 gtaaagctgg cagaacaagg aagaccacga acacaactta cactatgcat agtcatagta 33360 tcacaatctg gcaacagcgg gtggtcttca gtcatagaag ctcgggtttc attttcctca 33420 catcgtggta attgggctct ggtgtaaggg tgatgtctgg cgcatgatgt ggagcgtgcg 33480 cgcaaccttg tcataatgga gttgcttcct gacattctcg tattttgtat agcaaaacgc 33540 tgccctggca caacacactc ttcttcgtct tctatcctgc cgcttagtgt gttccgtctg 33600 ataattcaag tacagccaca ctcttaagtt ggtcaaaaga atgctggctt cagttgtaat 33660 caaaactcca tcatatttaa ttgttctaag gaaatcatcc acggtagcat atgcaaatcc 33720 caaccaagca atgcaactgg attgcgtttc aagcagcaga ggagagggaa gagacggaag 33780 aatcatgtta atttttattc caaacgatct cgcagtactt caaattgtag atcgcgcaga 33840 tggcatctat cgcccccact gtgttggtga aaaagcacag ctaaatcaaa agaaatgcga 33900 ttttcaaggt gctcaacggt ggcttccaac aaagcctcca cgcgcacatc caaaaacaaa 33960 agaataccaa aagaaggagc attttctaac tcctcaaaca tcatattaca ttcctgcacc 34020 attcccagat aattttcagc tttccagcct tgaattattc gtgtcagttc ttgtggtaaa 34080 tccaaaccac acattacaaa caggtcccgg agggcgccct ccaccaccat tcttaaacac 34140 accctcataa tgacaaaata tcttgctcct gtgtcacctg tagcaaatta agaatggcat 34200 catcaattga catgcccttg gctctaagtt cttctctaag ttctagttgt agatactctc 34260 tcatattatc accaaactgc ttagccagaa gccccccggg aacaatagca ggggacgcta 34320 cagtgcagta caagcgcaga cctccccaat tggctccagc aaaaacaaga ttagaataag 34380 catactggga accaccagta atatcatcaa agttgctgga aatataatca ggcagagttt 34440 cttgtaaaaa ttgaataaaa gaaaaatttt ccaaagaaac attcaaaacc gttgggatgc 34500 aaatacaata ggttaccgcg ctgcgctcca acattgttag ttttgaatta gtctgcaaaa 34560 taaaagaaac aagcgtcata tcatagtagc ctgtcgaaca ggtggaaaaa tcagtctttc 34620 catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt cattgtgatt 34680 aaacaacagc accgaaagtt cctcgcggtg gccagcatga ataattcttg atgaagcata 34740 caatccagac atgttagcat cagttaaaga gaaaaaacag ccaacatagc ctctgggtat 34800 aattatgctt aattttaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34860 aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgttg ctcccggtcc 34920 ctctaaatag acatacaaag cctcatcagc catggcttac caggcaaagt acagcgggcg 34980 cacaaagcac aagctctaaa gaagctctaa aaacactctc caacctctcc acaatatata 35040 cacaagccct aaactgacgt aatgggagta aagtgaaaaa aaaataccgc caagcccaac 35100 acacaccccg aaactgcgtc agcaggaaaa agtacagttt cacttccgca ttcccaacaa 35160 gcgtaacttc ctctttctca tggtacgtca catccgatta acttgcaacg tcattttccc 35220 acggtcgcgc cgcccctttt agccgttaac cccgcagcca atcaccacac agcgcgcact 35280 tttttaaatt acctcattta catgttggca ccattccatc tataaggtat attatataga 35340 tag 35343 <210> 140 <211> 35083 <212> DNA <213> Human adenovirus type 9 <400> 140 ctatctatat aatatacccc acaaagtaaa caaaagttaa tatgcaaatg agcttttgaa 60 ttttaacggt ttcggggcgg agccaacgct gattggacga gagaagacga tgcaaatgac 120 gtcacgacgc acggctaacg gtcgccgcgg aggcgtggcc tagcccggaa gcaagtcgcg 180 gggctgatga cgtataaaaa agcggacttt agacccggaa acggccgatt ttcccgcggc 240 cacgcccgga tatgaggtaa ttctgggcgg atgcaagtga aattaggtca ttttggcgcg 300 aaaactgaat gaggaagtga aaagcgaaaa ataccggtcc ctcccagggc ggaatattta 360 ccgagggccg agagactttg accgattacg tgggggtttc gattgcggtg tttttttcgc 420 gaatttccgc gtccgtgtca aagtccggtg tttatgtcac agatcagctg atccgcaggg 480 tatttaaacc agtcgagtcc gtcaagaggc cactcttgag tgccagcgag tagagatttc 540 tctgagctcc gctcccagag accgagaaaa atgagacacc tgcgcctcct gccttcaact 600 gtgcccggtg agctggctgt gcttatgctg gaggactttg tggatacagt attggaggac 660 gaactgcatc caagtccgtt cgagctggga cccacacttc aggatctcta tgatctggag 720 gtagatgccc atgatgacga ccctaacgag gaggctgtga atttaatatt tccagaatct 780 atgattcttc aggctgacat agccaacgaa tctactccac ttcatacacc gactctgtca 840 cccatacctg aattggaaga ggaggacgaa ctagacctcc ggtgttatga ggaaggtttt 900 cctcccagcg attcagagga tgaacggggt gagcagacca tggctctgat ctcagactat 960 gcttgtgtga ttgtggagga gcaagatgtg attgaaaaat ctactgagcc agtacaaggc 1020 tgtaggaact gccagtacca ccgggataag tccggagatg tgaacgcctc ctgcgctttg 1080 tgctatatga aacagacttt cagctttatt tacagtaagt ggagtgaatg tgagagaggc 1140 tgagtgctta acacataact gtaatgcttg aacagctgtg ctaagtgtgg tttattttgt 1200 tactaggtcc ggtgtcagag gatgagttat caccctcaga agaagaccac ccgtctcccc 1260 ctgagctgtc aggcgaaacg cccctgcaag tgttcagacc caccccagtc agacccagtg 1320 gcgagaggcg agcggctgtt gacaaaattg aggacttgtt gcaggacatg ggtggggatg 1380 aacctttgga cctgagcttg aaacgcccca ggaactagac gcagctgcgc ttagtcatgt 1440 gtaaataaag ttgtacaata aaagtctatg tgacgcatgc aaggtgtggt ttatgactca 1500 tgggcggggc ttagtcctat ataagtggca acacctgggc acttgggcac agaccttcag 1560 ggagttcctg atggatgtgt ggactatcct tgcagacttt agcaagacac gccggcttgt 1620 agaggatagt tcagacgggt gctccgggtt ctggagacac tggtttggaa ctcctctatc 1680 tcgcctggtg tacacagtta agaaggatta taaagaggaa tttgaaaata tttttgctga 1740 ctgctctggc ctgctagatt ctctgaatct tggccaccag tcccttttcc aggaaagggt 1800 actccacagc cttgattttt ccagcccagg gcgcactaca gccggggttg cttttgtggt 1860 ttttctggtt gacaaatgga gccaggacac ccaactgagc aggggctaca tcctggactt 1920 cgcagccatg cacctgtgga gggcctggat caggcagcgg ggacagagaa tcttgaatta 1980 ctggcttcta cagccagcag ctccgggtct tcttcgtcta cacagacaaa catccatgtt 2040 ggaggaagaa atgaggcagg ccatggacga gaacccgagg agcggcctgg accctccgtc 2100 ggaagaggag ctggattgaa tcaggtatcc agcctgtacc cagagcttag caaggtgctg 2160 acatccatgg ccaggggagt taagagggag aggagcgatg ggggtaatac cgggatgatg 2220 accgagctga cggccagcct gatgaatcgg aagcgcccag agcgccttac ctggtacgag 2280 ctacagcagg agtgcaggga tgagttgggc ctgatgcagg ataaatatgg cctggagcag 2340 ataaaaaccc attggttgaa cccagatgag gattgggagg aggctattaa gaagtatgcc 2400 aagatagccc tgcgcccaga ttgcaagtac atagtgacca agaccgtgaa tatcagacat 2460 gcctgctaca tctcggggaa cggggcagag gtggtcatcg ataccctgga caaggccgcc 2520 ttcaggtgtt gcatgatggg aatgagagca ggagtgatga atatgaattc catgatcttc 2580 atgaacatga agttcaatgg agagaagttt aatggggtgc tgttcatggc caacagccac 2640 atgaccctgc atggctgcag tttcttcggc ttcaacaata tgtgcgcaga ggtctggggc 2700 gcttccaaga tcaggggatg taagttttat ggctgctgga tgggcgtggt cggaagaccc 2760 aagagcgaga tgtctgtgaa gcagtgtgtg tttgagaaat gctacctggg agtctctacc 2820 gagggcaatg ctagagtgag acactgctct tccctggaga cgggctgctt ctgcctggtg 2880 aagggcacag cctctctgaa gcataatatg gtgaagggct gcacggatga gcgcatgtac 2940 aacatgctga cctgcgattc gggggtctgc catatcctga agaacatcca tgtgacctcc 3000 caccccagaa agaagtggcc agtgtttgag aataacctgc tgatcaagtg ccatatgcac 3060 ctgggagcca gaaggggcac cttccagccg taccagtgca actttagcca gaccaagctg 3120 ctgttggaga acgatgcctt ctccagggtg aacctgaacg gcatctttga catggatgtc 3180 tcggtgtaca agatcctgag atacgatgag accaagtcca gggtgcgcgc ttgcgagtgc 3240 gggggcagac acaccaggat gcagccagtg gccctggatg tgaccgagga gctgagacca 3300 gaccacctgg tgatggcctg taccgggacc gagttcagct ccagtgggga ggacacagat 3360 tagaggtagg tcgagtgagt agtgggcgtg gctaaggtga ctataaaggc gggtgtctta 3420 cgagggtctt tttgcttttc tgcagacatc atgaacggga ccggcggggc cttcgaaggg 3480 gggcttttta gcccttattt gacaacccgc ctgccgggat gggccggagt tcgtcagaat 3540 gtgatgggat cgacggtgga tgggcgccca gtgcttccag caaattcctc gaccatgacc 3600 tacgcgaccg tggggagctc gtcgctcgac agcaccgccg cagccgcggc agccgcagct 3660 gccatgacag cgacgagact ggcctcgagc tacatgccca gcagcggcag cagcccctct 3720 gtgcccagtt ccatcatcgc cgaggagaaa ctgctggccc tgctggccga gctggaagcc 3780 ctgagccgcc agctggccgc cctgacccag caggtgtccg agctccgcga gcagcaacag 3840 cagcaaaata aatgattcaa taaacacaga ttctgattca aacagcaaag catctttatt 3900 atttattttt tcgcgcgcgg taggccctgg tccacctctc ccgatcattg agagtgcggt 3960 ggattttttc caggacccgg tagaggtggg attggatgtt gaggtacatg ggcatgagcc 4020 cgtcccgggg gtggaggtag caccactgca tggcctcgtg ctctggggtc gtgttgtaga 4080 tgatccagtc atagcagggg cgctgggcgt ggtgctggat gatgtctttg agaaggagac 4140 tgatggccac ggggagcccc ttggtgtagg tattggcgaa gcggttgagc tgggagggat 4200 gcatgcgggg ggagatgatg tgcagtttgg cctggatctt gaggttggcg atgttgccac 4260 ccagatcccg ccgggggttc atgttgtgca ggaccaccag gacggtgtag cccgtgcact 4320 tggggaactt gtcatgcaac ttggaaggga atgcgtggaa gaatttggag acgcccttgt 4380 gcccgcccag gttttccatg cattcatcca tgatgatggc gatgggcccg tgggctgcgg 4440 ctttggcaaa gacgtttctg gggtcagata catcataatt atgctcctgg gtgagatcat 4500 cataagacat tttaatgaat ttggggcgga gggtgccaga ttgggggacg atggttccct 4560 cgggccccgg ggcgaagttc ccctcacaga tctgcatctc ccaggctttc atctcggagg 4620 gggggatcat gtccacctgc ggggcgatga aaaaaacggt ttccggggct ggggtgatga 4680 gctgcgaaga gagcaggttt ctcaacagct gggacttgcc gcacccggtc gggccgtaga 4740 tgaccccgat gacgggttgc aggtggtagt tcaaggacat gcagctgccg tcgtcccgga 4800 ggaggggggc cacctcgttg agcatgtctc tgacttggag gttttcccga acgagctcgc 4860 cgaggaggcg gtccccgccc agcgagagga gctcttgcag ggaagcaaag tttttcaggg 4920 gcttgagtcc gtcggccatg ggcatcttgg cgagggtctg cgagaggagc tccaggcggt 4980 cccagagctc ggtgacgtgc tctacggcat ctcgatccag cagacttcct cgtttcgggg 5040 gttgggacga ctgcgactgt agggcacgag acgatgggcg tccagcgcgg ccagcgtcat 5100 gtccttccag ggtctcaggg tccgagtgag ggtggtctcc gtcacggtga aggggtgggc 5160 ccctggctgg gcgcttgcaa gggtgcgctt gagactcatc ctgctggtgc tgaaacgggc 5220 acggtcttcg ccctgcgagt cggcgagata gcagttgacc atgagctcgt agttgagggc 5280 ctcggcggcg tggcccttgg cgcggagctt gcccttggaa gagcgcccgc aggcgggaca 5340 gaggagggat tgcagggcgt agagcttggg ggcgagaaag acggactcgg gagcgaaagc 5400 gtccgctccg cagtgggcgc agacggtctc gcactcgacg agccaggtga gctctggctg 5460 ctcggggtca aaaaccagtt ttcccccgtt ctttttgatg cgcttcttac ctcgcgtctc 5520 catgagtctg tgtccgcgct cggtgacaaa caggctgtcg gtgtccccgt agacggactt 5580 gattggcctg tcctgcaggg gcgtcccgcg gtcctcctcg tagagaaact cggaccactc 5640 tgagacaaag gcgcgcgtcc acgccaagac aaaggaggcc acgtgcgagg ggtagcggtc 5700 gttgtccact agggggtcca ccttttccac cgtgtgcaga cacatgtccc cctcctccgc 5760 atccaagaag gtgattggct tgtaggtgta ggccacgtga ccgggggtcc ccgacggggg 5820 ggtataaaag ggggcgggtc tgtgctcgtc ctcactctct tccgcgtcgc tgtccacgag 5880 cgccagctgt tggggtaggt attccctctc gagagcgggc atgacctcgg cactcaggtt 5940 gtcagtttct agaaacgagg aggatttgat gttggcttgc cctgccgcga tgctttttag 6000 gagactttca tccatctggt cagaaaagac tattttttta ttgtcaagct tggtggcgaa 6060 ggagccatag agggcgttgg atagaagctt ggcgatggat ctcatggtct gatttttgtc 6120 acggtcggcg cgctccttgg ccgcgatgtt tagctggaca tactcgcgcg cgacgcactt 6180 ccattcgggg aagacggtgg tgcgctcgtc gggcacgatc ctgacgcgcc agccgcggtt 6240 atgcagggtg accaggtcca cgctggtggc cacctcgccg cgcaggggct cgttggtcca 6300 gcagagtctg ccgcccttgc gcgagcagaa cgggggcagc acatcaagca gatgctcgtc 6360 aggggggtcc gcatcgatgg tgaagatgcc cggacagagt tccttgtcaa aataatcgat 6420 ttttgaggat gcatcatcca aggccatctg ccactcgcgg gcggccagcg ctcgctcgta 6480 ggggttgagg ggcggacccc agggcatggg atgagtgagg gcggaggcgt acatgccgca 6540 gatgtcgtag acatagatgg gctccgagag gatgccgatg taggtgggat aacagcgccc 6600 cccgcggatg ctggcgcgca cgtagtcata caactcgtgc gagggggcca agaaggcggg 6660 gccgagattg gtgcgctggg gctgctcggc gcggaagacg atctggcgaa agatggcgtg 6720 cgagttggag gagatggtgg gccgttggaa gatgttaaag tgggcgtggg gcaagcggac 6780 cgagtcgcgg atgaagtgcg cgtaggagtc ttgcagcttg gcgacgagct cggcggtgac 6840 gaggacgtcc atggcgcagt agtccagcgt ttcgcggatg atgtcataac ccgcctctcc 6900 tttcttctcc cacagctcgc ggttgagggc gtactcctcg tcatccttcc agtactcccg 6960 gagcgggaat cctcgatcgt ccgcacggta agagcccagc atgtagaaat ggttcacggc 7020 cttgtaggga cagcagccct tctccacggg gagggcgtaa gcttgagcgg ccttgcggag 7080 cgaggtgtgc gtcagggcga aggtgtccct gaccatgact ttcaagaact ggtacttgaa 7140 atccgagtcg tcgcagccgc cgtgctccca gagctcgaaa tcggtgcgct tcttcgagag 7200 ggggttaggc agagcgaaag tgacgtcatt gaagagaatc ttgcctgctc gcggcatgaa 7260 attgcgggtg atgcggaaag ggcccgggac ggaggctcgg ttgttgatca cctgggcggc 7320 aaggacgatc tcgtcgaagc cgttgatgtt gtgcccgacg atgtagagtt ccatgaatcg 7380 cgggcggcct ttgatgtgcg gcagcttttt gagctcctcg taggtgaggt cctcggggca 7440 ttgcaggccg tgctgctcta gcgcccactc ctggagatgt gggttggctt gcatgaagga 7500 agcccagagc tcgcgggcca tgagggtctg gagctcgtcg cgaaagaggc ggaactgctg 7560 gcccacggcc atcttttctg gggtgacgca gtagaaggtg agggggtccc gctcccagcg 7620 atcccagcgt aagcgcacgg cgagatcgcg agcgagggcg accagctcgg gttcccccga 7680 gaatttcatg accagcatga aggggacgag ctgcttgccg aaggacccca tccaggtgta 7740 ggtttctaca tcgtaggtga caaagagccg ctccgtgcga ggatgagagc cgattgggaa 7800 gaactggatt tcctgccacc agttggacga gtggctgttg atgtgatgaa agtagaaatc 7860 ccgccggcga accgagcact cgtgctgatg cttgtaaaag cgtccgcagt actcgcagcg 7920 ctgcacgggc tgtacctcat ccacgagata cacagcgcgt cccttgagga ggaacttcag 7980 gagtggcggc cctggctggt ggctttcatg ttcgcctgcg tgggactcac cctggggctc 8040 ctcgaggacg gagaggctga cgagcccgcg cgggagccag gtccagatct cggcgcggcg 8100 ggggcggaga gcgaagacga gggcgcgcag ttgggagctg tccatggtgt cgcggagatc 8160 caggtccggg ggcagggttc tgaggttgac ctcgtagagg cgggtgaggg cgtgcttgag 8220 atgcagatgg tacttgatct ccacgggtga gttggtggtc gtgtccacgc attgcatgag 8280 cccgtagctg cgcggggcca cgaccgtgcc gcggtgcgct tttagaagcg gtgtcgcggg 8340 cgtgctcccg gcggcagcgg cggttctggc cccgcgggca ggggcggcag aggcacgtcg 8400 gcgtggcgct cgggcaggtc ccggtgctgc gccctgagag cgctggcgtg cgcgacgacg 8460 cggcggttga catcctggat ctgccgcctc tgcgtgaaga ccacgggccc cgtgactttg 8520 aacctgaaag acagttcaac agaatcaatc tctgcgtcat tgacggcggc ctgacgcagg 8580 atctcttgca cgtcgcccga gttgtcctgg taggcgatct cggtcatgaa ctgttcgatc 8640 tcctcctcct ggagatcgcc gcggcccgcg cgctccacgg tggcggcgag gtcattggag 8700 atgcggccca tgagctgcga gaaggcgccc aggccgctct cgttccagac gcggctgtag 8760 accacgtccc cgtcggcgtc gcgtgcgcgc atgaccacct gcgcgaggtt gagctccacg 8820 tgccgcgtga agacggcgta gttgcgcagg cgctggaaga ggtagttgag ggtggtggcg 8880 atgtgctcgg tgacgaagaa gtacatgatc cagcggcgca ggggcatctc gctgatgtcg 8940 ccgatggcct ccagcctttc catggcctcg tagaaatcca cggcgaagtt gaaaaactgg 9000 gcattgcggg ccgagaccgt gagctcgtct tccaggagcc ggatgagctc ggcgatggtg 9060 gcgcgcacct cgcgctcgaa atccccgggg gcctcctctt cttcctcttc ttccatgacg 9120 acctcttctt ctatttcttc ctctgggggc ggtggtggtg gcggggcccg acgacgacgg 9180 cgacgcaccg ggagacggtc gacgaagcgc tcgatcatct ccccgcggcg gcgacgcatg 9240 gtttcggtga cggcgcgacc ccgttcgcga ggacgcagcg tgaagacgcc gccggtcatc 9300 tcccggtaat ggggcgggtc cccgttgggc agcgataggg cgctgacgat gcatcttatc 9360 aattgcggtg taggggacgt gagcgcgtcg agatcgaccg gatcggagaa tctttcgagg 9420 aaagcgtcta gccaatcgca gtcgcaaggt aagctcaaac acgtagcagc cctgtggacg 9480 ctgttagaat tgcggttgct gatgatgtaa ttgaagtagg cgtttttgag gcggcggatg 9540 gtggcgagga ggaccaggtc cttgggtccc gcttgctgga tgcggagccg ctcggccatg 9600 ccccaggcct ggccctgaca ccggctcagg ttcttgtagt agtcatgcat gagcctctcg 9660 atgtcatcac tggcggaggc ggagtcttcc atgcgggtga ccccgacgcc cctgagcggc 9720 tgcacgagcg ccaggtcggc gacgacgcgc tcggcgagga tggcctgttg cacgcgggtg 9780 agggtgtcct ggaagtcgtc catgtcgaca aagcggtggt aggccccggt gttgatggtg 9840 taggtgcagt tggccatgag cgaccagttg acggtctgca ggccgggttg cacgacctcg 9900 gagtacctga gccgcgagaa ggcgcgcgag tcgaagacgt agtcattgca ggtgcgcacg 9960 aggtactggt agccgactag gaagtgcggc ggcggctggc ggtagagcgg ccagcgctgg 10020 gtggccggcg cgcccggggc caggtcctcg agcatgaggc ggtggtagcc gtagaggtag 10080 cgggacatcc aggtgatgcc ggcggcggtg gtggaggcgc gcgggaactc gcggacgcgg 10140 ttccagatgt tgcgcagcgg caggaaatag tccatggtcg gcacggtctg gccggtgaga 10200 cgcgcgcagt cattgacgct ctagaggcaa aaacgaaagc ggttgagcgg gctcttcctc 10260 cgtagcctgg cggaacgcaa acgggttagg ccgcgtgtgt accccggttc gagtcccctt 10320 gaatcaggct ggagccgcga ctaacgtggt attggcactc ccgtctcgac ccgagcccga 10380 tagccgccag gatacggcgg agagtccttt ttgccggcca aggggggtcg ctagacttga 10440 aagcgaccga aaaccctgcc gggtagtggc tcgcgcccgt agtctggaga agcatcgcca 10500 gggttgagtc gcggcagaac ccggttcgcg gacggccgcg gcgagcggga cttggtcacc 10560 ccgccgattt aaagacccac agccagccga cttctccagt tacgggagcg agcccccttt 10620 tttctttttg ccagatgcat cccgtcctgc gccaaatgcg tcccaccccc ccggcgacca 10680 ccgcgaccgc ggccgtagca ggcgccggcg ctagccagcc acagccacag acagagatgg 10740 acttggaaga gggcgaaggg ctggcgagac tgggggcgcc gtccccggag cgacaccccc 10800 gcgtgcagct gcagaaggac gtgcgcccgg cgtacgtgcc tgcgcagaac ctgttcaggg 10860 accgcagcgg ggaggagccc gaggagatgc gcgactgccg gtttcgggcg ggcagggagc 10920 tgcgcgaggg cctggaccgc cagcgcgtgc tgcgcgacga ggatttcgag ccgaacgagc 10980 agacggggat cagccccgcg cgcgctcacg tggcggcggc caacctggtg acggcctacg 11040 agcagacggt gaagcaggag cgcaacttcc aaaagagttt caacaaccac gtgcgcaccc 11100 tgatcgcgcg cgaggaggtg gccctgggcc tgatgcacct gtgggacctg gcggaggcca 11160 tcgtgcagaa cccggacagc aagcctctga cggcgcagct gttcctggtg gtgcagcaca 11220 gcagggacaa cgaggcgttc agggaggcac tgctgaacat cgccgagccc gagggtcgct 11280 ggctgctgga gctgatcaac atcttgcaga gcatcgtagt gcaggagcgc agcctgagct 11340 tggccgagaa ggtggcggcg atcaactact cggtgctgag cctgggcaag ttttacgcgc 11400 gcaagattta caagacgccg tacgtgccca tagacaagga ggtgaagata gacagctttt 11460 acatgcgcat ggcgctcaag gtgctgacgc tgagcgacga cctgggcgtg taccgcaacg 11520 accgcatcca caaggccgtg agcacgagcc ggcggcgcga gctaagcgac cgcgagctga 11580 tgctgagcct gcgccgggcg ctggtagggg gcgctgccgg cggcgaggag tcctacttcg 11640 acatgggggc ggacctgcat tggcagccga gccggcgcgc cttggaggcc gcctacggtc 11700 cagaggactt ggatgaggaa gaggaagagg aggaggatgc acccgctgcg gggtactgac 11760 gcctccgtga tgtgttttta gatgcagcaa gccccggacc ccgccataag ggcggcgctg 11820 caaagccagc cgtccggtct agcatcggac gactgggagg ccgcgatgca acgcatcatg 11880 gccctgacga cccgcaaccc cgagtccttt agacaacagc cgcaggccaa cagactctcg 11940 gccattctgg aggcggtggt cccctctcgg accaacccca cgcacgagaa ggtgctggcg 12000 atcgtgaacg cgctggcgga gaacaaggcc atccgtcccg acgaggccgg gctggtgtac 12060 aacgccctgc tggagcgcgt gggccgctac aacagcacga acgtgcagtc caacctggac 12120 cggctggtga cggacgtgcg cgaggccgtg gcgcagcgcg agcggttcaa gaacgagggc 12180 ctgggctcgc tggtggcgct gaacgccttc ctggcgacgc agccggcgaa cgtgccgcgc 12240 gggcaggacg attacaccaa ctttatcagc gcgctgcggc tgatggtgac cgaggttccc 12300 cagagcgagg tgtaccagtc gggcccggac tactttttcc agacgagccg gcagggcttg 12360 cagacggtga acctgagcca ggctttcaag aacctgcgag ggctgtgggg cgtgcaggcg 12420 cccgtgggcg accggtcgac ggtgagcagc ttgctgacgc ccaactcgcg gctgctgctg 12480 ctgctgatcg cgcccttcac cgacagcggc agcgtgaacc gcaactcgta cctgggccat 12540 ctgctgacgc tgtaccgcga ggccataggc caggcgcagg tggacgagca gaccttccag 12600 gagatcacta gcgtgagccg cgcgctgggg cagaacgaca ccgacagtct gagggccacc 12660 ctgaacttct tgctgaccaa tagacagcag aagatcccgg cgcaatatgc gctgtcggcc 12720 gaggaggaaa ggatcctgag atatgtgcag cagagcgtag ggctgttcct gatgcaggag 12780 ggggccaccc ccagcgccgc gctggacatg accgcgcgca acatggaacc tagcatgtac 12840 gccgccaacc ggccgttcat caataagctg atggactacc tgcaccgcgc ggcggtcatg 12900 aacacggact actttacaaa cgccatcctg aacccgcact ggctcccgcc gccggggttc 12960 tacacgggcg agtacgacat gcccgacccc aacgacgggt tcctgtggga cgacgtggac 13020 agcgtggtgt tctcgccgac ctttcaaaag cgccaggagg cgccgccgag cgagggcgcg 13080 gtggggagga gcccctttcc tagcttaggg agtttgcata gcttgccggg ctcggtgaac 13140 agcggcaggg tgagccggcc gcgcttgctg ggcgaggacg agtacctgaa cgactcgctg 13200 ctgcagccgc cgcgggccaa gaacgccatg gccaataacg ggatagagag tctggtggac 13260 aaactgaacc gttggaagac ctacgctcag gaccataggg atgcgcccgc gccgcggcga 13320 cagcgccacg accggcagcg gggcctggtg tgggacgacg aggactcggc cgacgatagc 13380 agcgtgttgg acttgggcgg gagcggtggg gtcaacccgt tcgcgcatct gcagcccaaa 13440 ctggggcgac ggatgttttg aaatgcaaaa taaaactcac caaggccata gcgtgcgttc 13500 tcttccttgt tagagatgag gcgtgcggtg gtgtcttcct ctcctcctcc ctcgtacgag 13560 agcgtgatgg cgcaggcgac cctggaggtt ccgtttgtgc ctccgcggta tatggctcct 13620 acggagggca gaaacagcat tcgttactcg gagctggctc cgcagtacga caccactcgc 13680 gtgtacttgg tggacaacaa gtcggcggac atcgcttccc tgaactacca aaacgaccac 13740 agcaacttcc tgaccacggt ggtgcagaac aacgatttca cccccgccga ggccagcacg 13800 cagacgataa attttgacga gcggtcgcgg tggggcggtg atctgaagac cattctgcac 13860 actaacatgc ccaatgtgaa cgagtacatg ttcaccagca agtttaaggc gcgggtgatg 13920 gtggctagga agcatccaga gggggtagtt gaaacagatt tgagtcagga taagcttgaa 13980 tatgagtggt ttgagtttac cctgcccgag ggaaactttt ccgagaccat gaccatagac 14040 ctgatgaaca acgccatctt ggaaaactac ttgcaagtgg ggcggcaaaa tggcgtgctg 14100 gagagcgata tcggagtcaa gtttgacagc agaaatttca agctgggctg ggacccggtg 14160 accaagctgg tgatgccagg ggtctacacc tacgaggcct tccacccgga cgtggtgctg 14220 ctgccgggct gcggggtgga cttcaccgag agccgcctga gcaacctcct gggcattcgc 14280 aagaagcaac ctttccaaga gggcttcaga atcatgtatg aggatctaga aggtggcaac 14340 atccccgccc tccttgatgt gcccaagtac ttggaaagca agaagaaagt tgaagacgaa 14400 actaaaaatg cagctgcggc tacagccgat acaaccacta ggggtgatac atttgcaact 14460 ccagcgcaag agacagcagc tgataagaag gtagaagtct tgcccattga aaaggatgag 14520 agtggtagaa gttacaacct gatccagggg acccacgaca cgctgtaccg cagttggtac 14580 ctgtcctata cctacgggga ccccgagaag ggggtgcagt cgtggacgct gctcaccacc 14640 ccggacgtca cctgcggcgc ggagcaagtc tactggtcgc tgccggacct catgcaagac 14700 ccagtcacct tccgctctac ccagcaagtc agcaactacc ccgtggtcgg cgccgagctc 14760 atgcccttcc gcgccaagag cttttacaac gacctcgccg tctactccca gctcatccgc 14820 agctacacct ccctcaccca cgtcttcaac cgcttccccg acaaccagat cctctgccgc 14880 ccgcccgcgc ccaccatcac caccgtcagt gaaaacgtgc ctgctctcac agatcacggg 14940 acgctaccgc tgcgcagcag tatccgcgga gtccagcgag tgaccgtcac tgacgcccgt 15000 cgccgcacct gtccctacgt ctacaaggcc ctgggcatag tcgcgccgcg cgtgctttcc 15060 agtcgcacct tctaaaaaaa tgtctattct catctcgccc agcaataaca ccggctgggg 15120 tcttactaga cccagcacca tgtacggagg agccaagaag cgctcccagc agcaccccgt 15180 ccgcgtccgc ggccacttcc gcgctccctg gggcgcttac aagcgcgggc ggacttccac 15240 cgccgtgcgc accaccgtcg acgacgtcat cgactcggtg gtcgccgacg cgcgcaacta 15300 tacccccgcc ccctccaccg tggacgcggt catcgacagc gtggtggccg acgcgcgcga 15360 ctatgccaga cgcaagagcc ggcggcgacg gatcgccagg cgccaccgga gcacgcccgc 15420 catgcgcgcc gcccgggctc tgctgcgccg cgccagacgc acgggccgcc gggccatgat 15480 gcgagccgcg cgccgcgctg ccactgcacc cacccccgca ggcaggactc gcagacgagc 15540 ggccgccgcc gccgccgcgg ccatctctag catgaccaga cccaggcgcg gaaacgtgta 15600 ctgggtgcgc gactccgtca cgggcgtgcg cgtgcccgtg cgcacccgtc ctcctcgtcc 15660 ctgatctaat gcttgtgtcc tcccccgcaa gcgacgatgt caaagcgcaa aatcaaggag 15720 gagatgctcc aggtcgtcgc cccggagatt tacggaccac cccaggcgga ccagaaaccc 15780 cgcaaaatca agcgggttaa aaaaaaggat gaggtggacg agggggcagt agagtttgtg 15840 cgcgagttcg ctccgcggcg gcgcgtaaat tggaaggggc gcagggtgca gcgcgtgttg 15900 cggcccggca cggcggtggt gttcacgccc ggcgagcggt cctcagtcag gagcaagcgt 15960 agctatgacg aggtgtacgg cgacgacgac atcctggacc aggcggcgga gcgggcgggc 16020 gagttcgcct acgggaagcg gtcgcgcgaa gaggagctga tctcgctgcc gctggacgaa 16080 agcaacccca cgccgagcct gaagcccgtg accctgcagc aggtgctgcc ccaggcggtg 16140 ctgctgccga gccgcggggt caagcgcgag ggcgagagca tgtacccgac catgcagatc 16200 atggtgccca agcgccggcg cgtggaggac gtgctggaca ccgtgaaaat ggatgtggag 16260 cccgaggtca aggtgcgccc catcaagcag gtggcgccgg gcctgggcgt gcagaccgtg 16320 gacattcaga tccccaccga catggatgtc gacaaaaaac cctcgaccag catcgaggtg 16380 cagaccgacc cctggctccc agcctccact gctaccgtct ccacttctac cgccgccacg 16440 gctaccgagc ctcccaggag gcgaagatgg ggcgccgcca gccggctgat gcccaactac 16500 gtggtgcatc cttccatcat cccgacgccg ggctaccgcg gcacccggta ctacgccagc 16560 cgccggcgcc cagccagcaa acgccgccgc cgcaccgcca cccgccgccg tctggccccc 16620 gcccgcgtgc gccgcgtgac cacgcgccgg ggccgctcgc tcgttctgcc caccgtgcgc 16680 taccacccca gcatccttta attcgtgtgc tgtgatactg ttgcagagag atggctctca 16740 cttgccgcct gcgcatcccc gtcccgaatt accgaggaag atcccgccgc aggagaggca 16800 tggcaggcag cggcctgaac cgccgccggc ggcgggccat gcgcaggcgc ctgagtggcg 16860 gctttctgcc cgcgctcatc cccataatcg ccgcggccat cggcacgatc ccgggcatag 16920 cttccgttgc gctgcaggcg tcgcagcgcc gttgatgtgc gaataaaagc ctctttagac 16980 tctgacacac ctggtcctgt atatttttag aatggaagac atcaattttg cgtccctggc 17040 tccgcggcac ggcacgcggc cgttcatggg cacctggaac gagatcggca ccagccagct 17100 gaacgggggc gccttcaatt ggagcagtgt ctggagcggg cttaaaaatt tcggctcgac 17160 gctccggacc tatgggaaca aggcctggaa tagtagcacg gggcagttgc taagggaaaa 17220 gctcaaagac cagaactttc agcagaaggt ggtggacggg ctggcctcgg gcattaacgg 17280 ggtggtggac atcgcgaacc aggccgtgca gcgcgagata aacagccgcc tggacccgcg 17340 gccgcccacg gtggtggaga tggaagatgc aactcttccg ccgcccaaag gcgagaagcg 17400 gccgcggccc gacgcggagg agacgatcct gcaggtggac gagccgccct cgtacgagga 17460 ggccgtcaag gccggcatgc ccaccacgcg catcatcgcg ccgctggcca cgggtgtaat 17520 gaaacccgcc acccttgacc tgcctccacc acccgcgccc gctccaccga aggcagctcc 17580 cgcggtcgtg caggcccccc cggtggcgac cgccgtgcgc cgcgtccccg cccgccgcca 17640 ggcccagaac tggcagagca cgttgcacag tatcgtaggc ctgggagtga aaagtctgaa 17700 gcgccgccga tgctattgaa agagaggaaa gaggacacta aagggagagc ttaacttgta 17760 tgtgccttac cgccagagaa cgcgcgaaga tggccacccc ctcgatgatg ccgcagtggg 17820 cgtacatgca catcgccggg caggacgcct cggagtacct gagcccgggt ctggtgcagt 17880 ttgcccgcgc caccgacacg tacttcagcc tgggcaacaa gtttaggaac cccacggtgg 17940 ccccgaccca cgatgtgacc acggaccggt cccagcgtct gacgctgcgc ttcgtgcccg 18000 tggatcgcga ggacaccacg tactcgtaca aggcgcgctt cactctggcc gtgggcgaca 18060 accgggtgct agacatggcc agcacttact ttgacatccg cggcgtcctg gaccgcggtc 18120 ccagcttcaa accctactcg ggcacagctt acaacagtct ggcccccaag ggtgccccca 18180 actccagcca gtggcttgca aaagacacca atgctggcga tcaagcatta aaaacccaca 18240 cacatggcgt agctgctatg gggggaacag atatcacagc aaagggtttg caaattggtg 18300 ttgacacgac tgaaaacaag aatgagccta tttatgcaaa tgaaatatac cagccagaac 18360 ctcaggtagg agaggaaaac ttgcaagatg ttgaaaactt ttatggaggc agagctctta 18420 aaaaagaaac caaaatgaaa ccttgctatg gctcgtttgc cagacccaca aatgaaaaag 18480 gcggtcaagc caaattttta actgacggcg atggtcagct aactaaaaat catgatatca 18540 caatgaattt ctttgacact cctggaggaa cagttggtca ggatactgaa cttgaagcag 18600 acattgttat gtatgctgag aatgtgcatc tggaaactcc agacacgcat gtggtgtaca 18660 aaccaggaac ttctgatgag agttcagaag caaatttggt tcagcagtcc atgccaaaca 18720 ggcccaacta catcggcttc agggacaact ttgtgggtct catgtactat aacagcactg 18780 gcaacatggg tgtgctggct ggtcaagcat ctcagttgaa tgctgtggtc gacttgcaag 18840 acagaaacac agagctgtct taccagctct tgctagattc tctgggtgac agaaccagat 18900 actttagcat gtggaactct gcagtggaca gttatgatcc tgatgtcagg attattgaaa 18960 atcacggtgt ggaagatgaa cttccaaact attgcttccc attggatgga gctggcacta 19020 atgctaccta ccaaggtgta aaagttaaaa atggccaaga tggagatgta aacgcagatt 19080 gggaaaaaga tccaaatctt gcttcacgaa accaaatatg caagggtaac atcttcgcca 19140 tggagatcaa cctccaggcc aacctgtgga agagttttct gtactcgaat gtggccctgt 19200 acctgcccga ctcatacaag tacacgccgg ccaacgtcac gctgcccgcc aataccaaca 19260 cctacgagta catgaacggc cgcgtggtag ccccctcgct ggtggacgcc tacatcaaca 19320 tcggcgcccg gtggtcgctg gaccccatgg acaacgtcaa cccattcaac caccaccgca 19380 acgcgggcct gcgttaccgc tccatgcttc tgggcaacgg ccgctacgtg cccttccaca 19440 tccaagtgcc ccaaaagttc tttgccatca agaacctgct cctgctcccc ggctcctaca 19500 cctacgagtg gaacttccgc aaggatgtca acatgatcct gcagagttcc ctcggaaacg 19560 acctgcgcgt cgacggcgcc tccgtccgct tcgacagcgt caacctctac gccacattct 19620 tccccatggc gcacaacacc gcctccaccc tggaagccat gctgcgcaac gacaccaacg 19680 accagtcctt caacgactac ctctcggccg ccaacatgct ctaccccatc ccggccaagg 19740 ccaccaacgt gcccatctcc atcccctcgc gcaactgggc cgccttccgc ggctggagtt 19800 tcacccggct caagaccaaa gaaactccct ccctcggctc gggtttcgat ccctactttg 19860 tatactcggg ttccatcccc tacctcgacg ggaccttcta cctcaaccac accttcaaga 19920 aggtctccat catgttcgac tcctcggtca gctggcccgg caacgaccgg ctgctcacgc 19980 cgaacgagtt cgagatcaag cgcagtgtcg acggggaggg ctacaatgtg gcccaatgca 20040 acatgaccaa ggactggttc ctcgtccaga tgctctccca ctacaacatc ggctaccagg 20100 gcttccacgt gcccgagggc tacaaggacc gcatgtactc cttcttccgc aacttccagc 20160 ccatgagcag gcaggtggtc gatgagatca actacaagga ctacaaggcc gtcaccctgc 20220 ccttccagca caacaactcg ggcttcaccg gctaccttgc acccaccatg cgtcaggggc 20280 agccctaccc cgccaacttc ccctatcctc tcatcggcca gacagccgtg ccctctgtca 20340 cccagaaaaa gttcctctgc gacagggtca tgtggcgcat ccccttctcc agcaacttca 20400 tgtccatggg cgccctcacc gacctgggtc agaacatgct ctatgccaac tcggcccacg 20460 cgctcgacat gaccttcgag gtggacccca tggatgagcc caccctcctc tatcttctct 20520 tcgaagtttt cgacgtggtc agagtgcacc agccgcaccg cggcgtcatc gaggccgtct 20580 acctgcgcac gcccttctcc gccggcaacg ccaccaccta agcatgagcg gctccagcga 20640 acgagagctc gcggccatcg tgcgcgacct gggctgcggg ccctactttt tgggcaccca 20700 cgacaagcgc ttcccgggct tcctcgccgg cgacaagctg gcctgcgcca ttgtcaacac 20760 ggccggccgc gagaccggag gcgtgcactg gctcgccttc ggctggaacc cgcgctcgcg 20820 cacctgctac atgttcgacc catttgggtt ctcggaccgc cggctcaagc agatttacag 20880 cttcgagtac gaggctatgt tgcgccgaag cgccctggct tcctcgcccg accgctgtct 20940 cagcctcgag cagtccaccc agaccgtgca ggggcccgac tccgccgcct gcggactttt 21000 ctgttgcatg ttcttgcatg ccttcgtgca ctggcccgac cgacccatgg acgggaaccc 21060 caccatgaac ttgctgacgg gggtgcccaa cggcatgcta caatcgccac aggtgctgcc 21120 caccctccgg cgcaaccagg aggagctcta ccgcttcctc gcgcgccact ccccttactt 21180 tcgctcccac cgcgccgcca tcgaacacgc caccgctttt gacaaaatga aacaactgcg 21240 tgtatctcaa taaacagcac ttttatttta catgtactgg agtatatgca agttatttaa 21300 aagtcgaagg ggttctcgcg ctcgtcgttg tgcgccgcgc tggggagggc cacgttgcgg 21360 tactggaact tgggctgcca cttgaactcg gggatcacca gtttgggcac tggggtctcg 21420 gggaaggtct cgctccacat gcgccggctc atctgcaggg cgcccagtat gtccggggcg 21480 gagatcttga aatcgcagtt ggggccggtg ctctgcgcgc gcgagttgcg gtacacgggg 21540 ttgcagcact ggaacaccat cagactgggg tacttcacac tggccagcac gctcttgtcg 21600 ctgatctgat ccttgtccag gtcctcggcg ttgctcaggc cgaacggggt catcttgcac 21660 agctggcggc ccaggaaggg cacgctctga ggcttgtggt tacactcgca gtgcacgggc 21720 atcagcatca tccccgcgcc gcgctgcata ttcgggtaga gggccttgac aaaggccgag 21780 atctgcttga aagcttgctg ggccttggcc ccctcgctga aaaacaggcc gcagctcttc 21840 ccgctgaact ggttattccc gcacccggca tcatgcacgc agcagcgcgc gtcatggctg 21900 gtcagttgca ccacgctccg tccccagcgg ttctgggtca ccttggcctt gctaggctgc 21960 tccttcaacg cgcgctggcc gttctcgctg gtcacatcca tctccaccac gtggtccttg 22020 tggatcatca ccgtcccgtg caaacacttg agctggcctt ccacctcggt gcagccgtga 22080 tcccacaggg cgcagccggt gcactcccaa ttcttgtgtg cgatcccgct gtggctgaag 22140 atgtaacctt gcaacaggcg acccatgacg gtgctaaatg atttactggt gctgaaggtc 22200 agttgcagac cgcgggcctc ctcgttcatc caggtctggc acatcttttg gaagatctcg 22260 gtctgctcgg gcatgagctt gtaagcatcg cgcaggccgc tgtcgacgcg gtagcgttcc 22320 ataagcacgt tcatggtatc catgcccttc tcccaggacg agaccagagg cagactcagg 22380 gggttgcgca cgttcagaat accgggggtc gcgggctcga cgatgcgttt tccgtccttg 22440 ccttccttca acagaaccgg cggctggctg aatcccactc ccacgatcac ggcatcttcc 22500 tggggcatct cttcgtcggg gtctaccttg gtcacatgct tggtctttct ggcttgcttc 22560 ttttttggag ggctgtccac ggggaccacg tcctcctcgg aagacccgga gcccacccgc 22620 tgatactttc ggcgcttggt gggcagagga ggtggaggcg aggggctcct ctcctgctcc 22680 ggcggatagc gcgccgaccc gtggccccgg ggcggagtgg cctctcgctc catgaaccgg 22740 cgcacgtcct gactgccgcc ggccattgtt tcctagggga agatggagga gcagccgcgt 22800 aagcaggagc aggaggagga cttaaccacc cacgagcaac ccaaaatcga gcaggacctg 22860 ggcttcgaag agccggctcg tctagaaccc ccacaggatg aacaggagca cgagcaagac 22920 gcaggccagg aggagaccga cgctgggctc gagcatggct acctgggagg agaggaggat 22980 gtgctgctga aacacttgca gcgccagtcc ctcatcctcc gggacgccct ggccgaccgg 23040 agcgaaaccc ccctcagcgt cgaggagctg tgtcgggcct acgagctcaa cctcttctcg 23100 ccgcgcgtgc cccccaaacg ccagcccaac ggcacctgcg agcccaaccc gcgtctcaac 23160 ttctatcccg ttttcgcggt ccccgaggcc cttgccacct atcacatttt tttcaagaac 23220 caaaagatcc ccgtctcctg ccgcgccaac cgcacccgcg ccgacgcgct cctcgctctg 23280 gggcccggcg cgcgcatacc tgatatcgct tccctggaag aggtgcccaa gatcttcgaa 23340 gggctcggtc gggacgagac gcgcgcggcg aacgctctga aagaaacagc agaggaagag 23400 ggtcacacta gcgccctggt agagttggaa ggcgacaacg ccaggctggc cgtgctcaag 23460 cgcagcgtcg agctcaccca ctttgcctac cccgccgtca acctcccgcc caaggtcatg 23520 cgtcacatca tggatcagct catcatgccc cacatcgaag ccctcgatga aagtcaggag 23580 cagcgccccg aggacgcccg acccgtggtc agcgacgaga tgctcgcgcg ctggctcggg 23640 acccgcgagc cccaggcttt ggaacagcgg cgcaagctca tgctggccgt ggtcctggtc 23700 accctcgagc tcgaatgcat gcgccgcttc ttcagcgacc ccgagaccct gcgcaaagtc 23760 gaggagaccc tgcactacac tttcagacac ggtttcgtca ggcaggcctg caagatttcc 23820 aacgtggagc tgaccaacct ggtctcctgc ctggggatcc tgcatgagaa ccgcctggga 23880 cagaccgtac tccactctac cctgaagggc gaggcgcgga gggactatgt ccgcgactgc 23940 gtctttctct ttctctgcca cacatggcaa gcagccatgg gcgtgtggca gcagtgtctc 24000 gaggacgaga acctgaagga gctggacaag cttcttgcta gaaaccttaa aaagctttgg 24060 acgggcttcg acgagcgcac cgtcgcctcg gacctggccg agatcgtctt ccccgagcgc 24120 ctgaggcaga cgctgaaagg cgggctgccc gacttcatga gccagagcat gttgcaaaac 24180 taccgcactt tcattctcga gcgatcgggg atgctgcccg ccacctgcaa cgctttcccc 24240 tccgactttg tcccgctgag ctaccgcgag tgtcccccgc cgctgtggag ccactgctac 24300 ctcttgcagc tggccaacta catcgcctac cactcggacg tgatcgagga cgtgagcggc 24360 gaggggctgc tcgagtgcca ctgccgctgc aacctgtgct ccccgcaccg ctccctggtc 24420 tgcaaccccc agctccttag cgagacccag gtcatcggta ccttcgagct gcaaggtccg 24480 caggagtcca ccgctccgct gaaactcacg ccggggttgt ggacttccgc gtacctgcgc 24540 aaatttgtac ccgaggacta ccacgcccat gagataaagt tcttcgagga ccaatcgcgg 24600 ccgcagcacg cggatctcac ggcctgcgtc atcacccagg gcgcgatcct cgcccaattg 24660 cacgccatcc aaaaatcccg ccaagagttt cttctgaaaa agggtagagg ggtctacctg 24720 gacccccaga cgggcgaggt gctcaacacg ggtctccccc agcatgccga ggaagaagca 24780 ggagccgcta gtggaggaga tggaagaaga atgggacagc caggcagagg aggacgaatg 24840 ggaggaggag acagaggagg aagaattgga agaggtggaa gaggagcagg caacagagca 24900 gcccgtcgcc gcaccatccg cgccggcagc cccggcggtc acggatacaa cctccgcagc 24960 tccggccaag cctcctcgta gatgggatcg agtgaagggc gacggtaagc acgagcggca 25020 gggctaccga tcatggaggg cccacaaagc cgcgatcatc gcctgcttgc aagactgcgg 25080 ggggaacatc gctttcgccc gccgctacct gctcttccac cgcggggtga acatcccccg 25140 caacgtgttg cattactacc gtcaccttca cagctaagaa aaagcaagta agagaagtcg 25200 ccggaggagg cctgaggatc gcggcgaacg agcccttgac caccagggag ctgaggaacc 25260 ggatcttccc cactctttat gccatttttc agcagagtcg aggtcagcag caagagctca 25320 aagtaaaaaa ccggtctctg cgctcgctca cccgcagttg cttgtaccac aaaaacgaag 25380 atcagctgca gcgcactctc gaagacgccg aggctctgtt ccacaagtac tgcgcgctca 25440 ctcttaaaga ctaaggcgcg cccacccgga aaaaaggcgg gaattacctc atcgccacca 25500 tgagcaagga gattcccacc ccttacatgt ggagctatca gccccagatg ggcctggccg 25560 cgggcgcctc ccaagactac tccacacgca tgaactggct cagtgccggc ccctcgatga 25620 tatcacgggt caacggggtc cgcagtcatc gaaaccagat attgttggag caggcggcgg 25680 tcacctccac gcccagggca aagctcaacc cgcgtaattg gccctccacc ctggtgtatc 25740 aggaaatccc cgggccgact accgtactac ttccgcgtga cgcactggcc gaagtccgca 25800 tgactaactc aggtgtccag ctggccggcg gcgcttcccg gtgcccgctc cgcccacaat 25860 cgggtataaa aaccctggtg atccgaggca gaggcacaca gctcaacgac gagttggtga 25920 gctcttcgat cggtctgcga ccggacggag tgttccaact agccggagcc gggagatcgt 25980 ccttcactcc caaccaggcc tacctgacct tgcagagcag ctcttcggag cctcgctcgg 26040 gaggcatcgg aaccctccag ttcgtggagg agtttgtgcc ctcggtctac ttcaacccct 26100 tctcgggatc gccaggcctc tacccggacg agttcatacc gaacttcgac gcagtgagag 26160 aagcggtgga cggctacgac tgaatgtccc atggtgactc tgctgagctc gctcggttga 26220 ggcatctgga ccactgccgc cgcctgcgct gcttcgcccg ggagagctgc ggactcatct 26280 actttgagtt tcccgaggag caccccaacg gtcctgcaca cggagtgcgg atcaccgtag 26340 agggcaccac cgagtctcac ctggtcaggt tcttcaccca gcaacccttc ctggtcgagc 26400 gggaccgggg cgccaccacc tacaccgtct actgcatctg tccgaccccg aagttgcatg 26460 agaatttttg ctgtactctt tgtggtgagt ttaataaaag ctaaactctt gcaatactct 26520 ggaccttgtc gtcatcaact caacgagacc gtctacctca ccaaccagac tgaggtaaaa 26580 ctcacctgca gaccacacaa gacctatatc atctggttct tcgagaacac ctcatttgca 26640 gtctcaaaca ctcactgcaa cgacggtgtt gaacttccaa acaacctttc cagtggactg 26700 agttacgata cacatagagc taagctcgtc ctctacaatc ctttcgtaga gggaacctac 26760 cactgccaga gcggaccttg cttccacagt tttactttgg tgaacgttac cggcagcagc 26820 acagccgctc cagaacctaa ccttccttct gatactatca aacctcgttt cggaggtgag 26880 ctaaggcttc ccccttctga ggagggggtt agcccatacg aagtggtcgg gtatttgatt 26940 ttaggggtgg tcctgggtgg gtgcatagcg gtgctagctc agctgccttg ctgggtagaa 27000 atcaaaatct ttatatgctg ggtcagacat tgtggggagg aactatgaag gggctcttgc 27060 tgattatcct ttccctggtg gggggtgtgc tgtcatgcca cgaacagcca cgatgtaaca 27120 tcaccacagg caatgagagg agtgtcatat gcacagtagt catcaaatgc gagcatgaat 27180 gccctctcaa catcacattc aaaaaccgta ccatggggaa tgcatgggtg ggcgactggg 27240 aaccaggaga tgagcagaac tacacggtca ctgtccatgg tagcgatgga aatcacactt 27300 tcggtttcaa attcattttt gaagtcatgt gtgatatcac actgcatgtg gctagacttc 27360 atggcttgtg gccccctacc aaggaaaaca tggttgggtt ttctttggct tttgtgatca 27420 tggcctgctt tatgtcaggt ctgctggtag gagctctagt gtggttcctg aaacgcaagc 27480 ccaggtatgg aaatgaggag aaggaaaaat tgctataaat tctttttctt ttcacagcac 27540 catgaatact ttgaccagtg tcgtgctgct ctctcttctt gtagctttta gtcaggcagg 27600 aattattaac ttaaatgtat catggggaat gaatctaact ttagtgggac cctcagacct 27660 gccagttaca tggtatgatg gaaagggaat gcagttttgt gatggaaata caattaagaa 27720 cccacaaatc aagcatagct gtaatcaaca gaatctaact ttacttaatg ctgacaagtc 27780 tcatgaaaga acttacctag gttacagaca tgacagtaag ggaaaagtag actataaggt 27840 tacagtcata ccacctcctc cagccactcg caagcctttg tcagagcctc attatgttac 27900 tgtgactatg ggcgataaca taactttagt gggaccctca gacctgccag ttacatggta 27960 tgatggagaa ggaaataaat tctgcgatgg agaaaaagtt gaacatgcag aatttaatca 28020 tacatgtaac atccagaacc tgacactgct ctttgtcaac ttaacgcata atggagcata 28080 cattggttat aacaaagacg gttctgatag agaattatat gaggtgtcag tcaaaacctt 28140 gtttcagaac ggggctggac aaagtaaggt tgaacaaggt aataaaggga aacctaatac 28200 tgctcaaagt ggtggtaaaa aaaccaaaac agaacataga aaccagagtc caaaaagaaa 28260 atcaacaaat aaccttcagc caacacaatt gtatgttagg ccttttacta atgttagttt 28320 aactggacct ccaaatggca aggttacttg gtatgatggc gaacttaatg atccatgtga 28380 acaaaagtac aaactcagaa ctttttgcaa tcagcaaaat ctaactttaa ttaatgtaag 28440 cagcacttat gatggcatct attatggcac tgatgaaaaa gataaggcaa atcgttacag 28500 aataaaagta aatactacaa atcacaaaac tgttaaaatt aagccacata ccagagaacc 28560 tcctgctgta caagaaaaac agtttgaatt acaagatgca gaaactgatg aaaacgaatc 28620 aaaaattccc tcagctactg tggcaatcgt ggtgggagtg attgcgggct ttgtaactct 28680 gatcattgtc ttcatatgct acatctgctg ccgcaagcgt cccaggtcat acaatcatat 28740 ggtagaccca ctactcagct tctcttactg aaactcagtc actctcattt cagaaccatg 28800 aaggctttca cagcttgcgt tctgattagc atagtcacac ttagttcagc tgcaatgatt 28860 aatgttaatg tcactagagg tggtaaaatt acattgaatg ggacttatcc acaaactaca 28920 tggacaagat atcataaaga tggatggaaa aatatctgtg aatggaatgt tactgcatat 28980 aaatgcttca ataatggaag cattactatt actgccactg ccaacattac ttctggcaca 29040 tacaaagctg aaagctataa aaatgaaatc aaaaaactaa cctataaaaa caacaaaacc 29100 acatttgaag attctggaaa ttatgaacat caaaaattat ctttttatat gttgacaata 29160 attgaactgc ctacaactaa ggctcccacc acaaccagta caactattaa gaccactact 29220 cacactacag tgcaaaatac tactttattg attgggtttt tactgagaga gaatgaaagt 29280 actactgaac agacagaggc tacctcaagt gccttcagca gcactgcaaa tttaacttcg 29340 cttgcttgga ctaatgaaac cggagtatca ttgatgcatg gccagcctta ctcaggtttg 29400 gatattcaaa ttacttttct ggttgtctgt gggatcttta ttcttgtggt tcttctgtac 29460 tttgtctgct gcaaagccag agagaaatct aggaggccca tctacaggcc agtgattggg 29520 gaacctcagc cactccaagt ggatggaggc ttaaggaatc ttctcttctc ttttacagta 29580 tggtgatcag ccatgattcc taggttcttc ctatttaaca tcctcttttg tctcttcaac 29640 atctgtgctg ccttcgcggc cgtctcgcac gcctcgcccg actgtctagg gcctttcccc 29700 acctacctcc tctttgccct gctcacctgc acctgcgtct gcagcattgt ctgcgtggtc 29760 atcaccttcc tgcagctcat cgactggtgc tgcgcgcgct ataattatct ccaccacagt 29820 cccgaataca gggacgagaa cgtagccaga atcttaaggc tcatctgacc atgcagactc 29880 tgctcatgct gctatccctc ctatcccctg ccctcgccac ttctgctgac tctaaatgca 29940 aattcgcgga gatatggaat ttcttagatt gctatcagga gaaaattgat atgccctcct 30000 attacttggt gattgtggga atagtcatgg tctgctcctg cactttcttt gccatcatga 30060 tctacccctg ttttgatctc ggctggaact ctgttgaggc attcacatac acactagaaa 30120 gcagttcact agcctccacg ccaccgccca caccgcctcc ccgcagaaat cagttcccac 30180 tgattcagta cttagaagag ccccctcccc ggcccccttc cactgttagc tactttcaca 30240 taaccggcgg cgatgactga ccaccacctg gacctcgaga tggacggcca ggcctccgag 30300 cagcgcatcc tgcaactgcg cgtccgtcag cagcaggagc gggccgccaa ggagctcctc 30360 gatgccatca acatccacca gtgcaagaag ggcatcttct gccttgtcaa acaggcaaag 30420 atcacctacg agctcgtgtc cggcggcaag cagcatcgcc tcacctatga gctgccccag 30480 cagaagcaga agttcacctg catggtgggc gtcaacccca tagtcatcac ccagcagtcg 30540 ggcgagacca acggctgcat ccactgctcc tgcgaaagcc ccgagtgcat atactccctc 30600 ctcaagaccc tttgcggact ccgcgacctc ctccccatga actgatgttg attaaaagca 30660 cgaaaaccaa tcagaccctt cccccatttc cccattccca attactcata aaataaatca 30720 ttggaattaa tcattcaata aaaatcactt acttgaaatc tgaaagtatg tctctggtgt 30780 agttgttcag cagcacctcg ttaccctcct cccagctctg gtattccagt ccccggcggg 30840 cggcgaactt cctccacacc ttgaaaggga tgtcaaattc ctggtccaca attttcattg 30900 tcttccctct cagatgtcaa agaggctccg ggtggaagat gacttcaacc ccgtctaccc 30960 ctatggctac gcgcggaatc agaatatccc cttcctcact cccccctttg tctcctccga 31020 tggattccaa aacttccccc ctggggtcct gtcactcaaa ctggctgacc caatagccat 31080 cgtcaatggg aatgtctcac tcaaagtggg agggggtctc actttgcaag atggaactgg 31140 aaaactaaca gtcaatgctg atccaccttt gcaacttaca aacaacaaat tagggattgc 31200 tttggacgct ccatttgatg ttatagacaa taaactcaca ttgttagcgg gccatggctt 31260 gtctattata acaaaagaaa catcaacact gcctggcttg attaatactc ttgtagtatt 31320 aactggaaag ggtattggaa cagaatcaac agataatggc ggaagcgtat gtgttagagt 31380 tggagaaggt ggcggcttat catttaataa tgatggagac ttggtagcat ttaataaaaa 31440 agaagataag cgcaccctat ggacaactcc agacacatct ccaaattgca agattgatca 31500 agataaggac tctaagttaa ctctggtcct tacaaagtgt ggaagtcaaa tattggctaa 31560 tgtgtcatta attgtcgtag ctggtaagta caaaattatc aataacaata ctcaaccagc 31620 tctcaaagga tttaccatta aattattgtt tgatgaaaat ggagtactta tggaatcttc 31680 aaatcttggt aaatcatatt ggaactttag aaatgaaaat tcaattatgt caacagctta 31740 tgaaaaagct attggattca tgcctaattt ggtagcctat ccaaaaccta ccgctggctc 31800 taaaaaatat gcaagagata tagtttatgg aaacatctac cttggtggaa agccagatca 31860 accagtaacc attaaaacta cctttaatca ggaaactgga tgtgaatatt ctatcacatt 31920 tgattttagt tgggccaaga cttatgtaaa tgttgaattt gaaacaacct cttttacctt 31980 ttcctatatc gcccaagaat gaaagaccaa taaacgtgtt tttcatttca aaattttcat 32040 gtatctttat tgatttttac accagcacgg gtagtcagtc tcccaccacc agcccatttc 32100 acagtgtaca ctgttctctc agcacgggtg gccttaaata gggaaatgtt ctcattagtg 32160 cgggaactgg acttggggtc tataatccac acagtttcct ggcgagccaa acgggggtcg 32220 gtgattgaga tgaagccgtc ctctgaaaag tcatccaagc gagcctcaca gtccaaggtc 32280 acagtctggt ggaatgagaa gaacgcacag attcatactc ggaaaacagg atgggtctgt 32340 gcctctccat cagcgccctc agcagtctct gccgccgggg ctcggtgcgg ctgctgcaga 32400 ttggatcggg atcgcaagtc tctctgacta taatccccac agccttcagc atcagtctcc 32460 tggtgcgtcg ggcacagcac cgcatcctga tctctgccat gttctcacag taagtgcagc 32520 acataatcac catgttattc agcagcccat aattcagggc gctccagcca aagctcatgt 32580 tggggatgat ggaacccacg tgaccatcgt accagatgcg gcagtatatc aggtgcctgc 32640 ccctcataaa cacactgccc atatacatga tctctttggg catgtttctg ttcacaatct 32700 gacggtacca ggggaagcgc tggttgaaca tgcacccgta aatgactctc ctgaaccaca 32760 cggccagcag ggtgcctccc gcccgacact gcagggagcc cggggatgaa cagtggcaat 32820 gcaggatcca gcgctcgtac ccgctcacca tctgagctct caccaagtcc agggtagcag 32880 ggcacaggca cactgacata catcttttta aaatttttat ttcctctggg gtcaggatca 32940 tatcccaggg gactggaaac tcttggagca gggtaaagcc agcagcacat ggtaatccac 33000 ggacagaact tacattatga taatctgcat gatcacaatc gggcaacagg ggatgttgtt 33060 cagtcagtga agccctggtt tcctcatcag atcgtggtaa acgggccctg cgatatggat 33120 gatggcggag cgagctggat tgaatctcgg tttgcattgt agtggattct cttgcgtacc 33180 ttgtcgtact tctgccagca gaaatgggcc cttgaacagc agatacccct cctgcggccg 33240 tcctttcgct gctgccgctc agtcatccaa ctgaagtaca tccattctcg aagattctgg 33300 agaagttcct ctgcatctga tgaaataaaa aacccgtcca tgcgaattcc cctcatcaca 33360 tcagccagga ctctgtaggc catccccatc cagttaatgc tgccttgtct atcattcaga 33420 gggggcggtg gcaggattgg aagaaccatt tttattccaa acggtctcga aggacgataa 33480 agtgcaagtc acgcaggtga cagcgttccc ctccgctgtg ctggtggaaa cagacagcca 33540 ggtcaaaacc cactctattt tcaaggtgct cgaccgtggc ttcgagcagt ggctctacgc 33600 gtacatccag cataagaatc acattaaagg ctggccctcc atcgatttca tcaatcatca 33660 ggttacattc ctgcaccatc cccaggtaat tctcattttt ccagccttga attatctcta 33720 caaattgttg gtgtaagtcc actccgcaca tgtggaaaag ctcccacagt gccccctcca 33780 ctttcataat caggcagacc ttcataatag aaacagatcc tgctgctcca ccacctgcag 33840 cgtgttcaaa acaacaagat tcaataaggt tctgccctcc gccctgagct cgcgcctcaa 33900 tgtcagctgc aaaaagtcac ttaagtcctg ggccactaca gctgacaatt cagagccagg 33960 gctaagcgtg ggactggcaa gcgtaaggga aaactttaat gctccaaagc tagcacccaa 34020 aaactgcatg ctggaataag ctctctttgt gtctccggtg atgccttcca aaatgtgagt 34080 gataaagcgt ggtagttttt ctttaatcat ttgcgtaata gaaaagtcct ctaaataagt 34140 cactaggacc ccagggacca caatgtggta gcttacaccg cgtcgctgaa gcatggttag 34200 tagagatgag agtctgaaaa acagaaagca tgcactaaac taaggtggct atttttactg 34260 aaggaaaaat cactctctcc agcaacaggg tacccactgg gtggcccttg cggacataca 34320 aaaatcggtc cgtgtgatta aaaagcagca cagtaagttc ctgtcttctt ccggcaaaaa 34380 tcacatcgga ctgggttagt atgtccctgg catggtagtc attcaaggcc ataaatctgc 34440 cctgatatcc agtaggaacc agcacactca cttttaggtg aagcaatacc accccatgcg 34500 gaggaatgtg gaaagattca gggcaaaaga aggtatatct attgctagtc ccttcctgga 34560 cgggagcgat ccctccagga ctatctatga aagcatacag agattcagcc atagctcagc 34620 ccgcttacca gtagacagag agcacagcag tacaagcgcc aacagcagcg actgactacc 34680 cactaaccca gctccctatt taaaggcacc ttacactgac gtaatgacca aaggtctaaa 34740 aaccccgcca aaaaaacaca cacgccctgg gtgttttttc gcgaaaacac ttccgcgttc 34800 tcacttcctc gtatcgattt cgtgactcaa cttccgggtt cccacgttac gtcacttctg 34860 cccttacatg taactcagtc gtagggcgcc atgttgccca cgtccaaaat ggtttccatg 34920 tccagccacg cctccgcggc gaccgttagc cgtgcgtcgt gacgtcattt gcatcgtctt 34980 ctctcgtcca atcagcgttg gctccgcccc gaaaccgtta aaattcaaaa gctcatttgc 35040 atattaactt ttgtttactt tgtggggtat attatataga tag 35083 <210> 141 <211> 34794 <212> DNA <213> Human adenovirus type 11 <400> 141 catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60 aaaagtgtgg atcgtgtggt gattggctgt ggggttaacg gctaaaaggg gcggtgcgac 120 cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180 acgcataaaa aggctttttt ctcacggaac tacttagttt tcccacggta tttaacagga 240 aatgaggtag ttttgaccgg atgcaagtga aaattgttga ttttcgcgcg aaaactgaat 300 gaggaagtgt ttttctgaat aatgtggtat ttatggcagg gtggagtatt tgttcagggc 360 caggtagact ttgacccatt acgtggaggt ttcgattacc gtgtttttta cctgaatttc 420 cgcgtaccgt gtcaaagtct tctgttttta cgtaggtgtc agctgatcgc tagggtattt 480 atacctcagg gtttgtgtca agaggccact cttgagtgcc agcgagaaga gttttctcct 540 ctgcgccggc agtttaataa taaaaaaatg agagatttgc gatttctgcc tcaggaaata 600 atctctgctg agactggaaa tgaaatattg gagcttgtgg tgcacgccct gatgggagac 660 gatccggagc cacctgtgca gctttttgag cctcctacgc ttcaggaact gtatgattta 720 gaggtagagg gatcggagga ttctaatgag gaagctgtaa atggcttttt taccgattct 780 atgcttttag ctgctaatga agggttagaa ttagatccgc ctttggacac ttttgatact 840 ccaggggtaa ttgtggaaag cggtacaggt gtaagaaaat tacctgattt gagttccgtg 900 gactgtgatt tgcactgcta tgaagacggg tttcctccga gtgatgagga ggaccatgaa 960 aaggagcagt ccatgcagac tgcagcgggt gagggagtga aggctgccaa tgttggtttt 1020 cagttggatt gcccggagct tcctggacat ggctgtaagt cttgtgaatt tcacaggaaa 1080 aatactggag taaaggaact gttatgttcg ctttgttata tgagaacgca ctgccacttt 1140 atttacagta agtgtgttta agttaaaatt taaaggaata tgctgttttt cacatgtata 1200 ttgagtgtga gttttgtgct tcttattata ggtcctgtgt ctgatgctga tgaatcacca 1260 tctcctgatt ctactacctc acctcctgag attcaagcac ctgttcctgt ggacgtgcgc 1320 aagcccattc ctgtgaagct taagcctggg aaacgtccag cagtggaaaa acttgaggac 1380 ttgttacagg gtggggacgg acctttggac ttgagtacac ggaaacgtcc aagacaataa 1440 gtgttccata tccgtgttta cttaaggtga cgtcaatatt tgtgtgacag tgcaatgtaa 1500 taaaaatatg ttaactgttc actggttttt attgcttttt gggcggggac tcaggtatat 1560 aagtagaagc agacctgtgt ggttagctca taggagctgg ctttcatcca tggaggtttg 1620 ggccattttg gaagacctta ggaagactag gcaactgtta gagaacgctt cggacggagt 1680 ctccggtttt tggagattct ggttcgctag tgaattagct agggtagttt ttaggataaa 1740 acaggactat aaccaagaat ttgaaaagtt gttggtagat tgcccaggac tttttgaagc 1800 tcttaatttg ggccatcagg ttcactttaa agaaaaagtt ttatcagttt tagacttttc 1860 aaccccaggt agaactgctg ctgctgtggc ttttcttact tttatattag ataaatggat 1920 cccgcagact catttcagca ggggatacgt tttggatttc atagccacag cattgtggag 1980 aacatggaag gttcgcaaga tgaggacaat cttaggttac tggccagtgc agcctttggg 2040 tgtagcggga atcctgaggc atccaccggt catgccagcg gttctggagg aggaacagca 2100 agaggacaac ccgagagccg gcctggaccc tccagtggag gaggcggagt agctgacttg 2160 tctcctgaac tgcaacgggt gcttactgga tctacgtcca ctggacggga taggggcgtt 2220 aagagggaga gggcatctag tggtactgat gctagatctg agttggcttt aagtttaatg 2280 agtcgcagac gtcctgaaac catttggtgg catgaggttc agaaagaggg aagggatgaa 2340 gtttctgtat tgcaggagaa atattcactg gaacaggtga aaacatgttg gttggagcct 2400 gaggatgatt gggaggtggc cattaaaaat tatgccaaga tagctttgag gcctgataaa 2460 cagtataaga ttactagacg gattaatatc cggaatgctt gttacatatc tggaaatggg 2520 gctgaggtgg taatagatac tcaagacaag gcagttatta gatgctgcat gatggatatg 2580 tggcctgggg tagtcggtat ggaagcagta acttttgtaa atgttaagtt taggggagat 2640 ggttataatg gaatagtgtt tatggccaat accaaactta tattgcatgg ttgtagcttt 2700 tttggtttca acaatacctg tgtagatgcc tggggacagg ttagtgtacg gggatgtagt 2760 ttctatgcgt gttggattgc cacagctggc agaaccaaga gtcaattgtc tctgaagaaa 2820 tgcatatttc aaagatgtaa cctgggcatt ctgaatgaag gcgaagcaag ggtccgccac 2880 tgcgcttcta cagatactgg atgttttatt ttgattaagg gaaatgccag cgtaaagcat 2940 aacatgattt gcggtgcttc cgatgagagg ccttatcaaa tgctcacttg tgctggtggg 3000 cattgtaata tgctggctac tgtgcatatt gtttcccatc aacgcaaaaa atggcctgtt 3060 tttgatcaca atgtgatgac gaagtgtacc atgcatgcag gtgggcgtag aggaatgttt 3120 atgccttacc agtgtaacat gaatcatgtg aaagtgttgt tggaaccaga tgccttttcc 3180 agaatgagcc taacaggaat ttttgacatg aacatgcaaa tctggaagat cctgaggtat 3240 gatgatacga gatcgagggt acgcgcatgc gaatgcggag gcaagcatgc caggttccag 3300 ccggtgtgtg tagatgtgac tgaagatctc agaccggatc atttggttat tgcccgcact 3360 ggagcagagt tcggatccag tggagaagaa actgactaag gtgagtattg ggaaaacttt 3420 ggggtgggat tttcagatgg acagattgag taaaaatttg ttttttctgt cttgcagctg 3480 tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540 tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600 tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660 cagctgcagc tgccgccgcc gcttctgttg ccgctaacac tgtgcttgga atgggttact 3720 atggaagcat catggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780 agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttctc 3840 agcaggtggt cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900 aaaaaaatcc cagaatcaat gaataaataa acaagcttgt tgttgattta aaatcaagtg 3960 tttttatttc atttttcgcg cacggtatgc cctagaccac cgatctctat cattgagaac 4020 tcggtggatt ttttccagga tcctatagag gtgggattga atgtttagat acatgggcat 4080 taggccgtct ttggggtgga gatagctcca ttgaagggat tcatgctccg gggtagtgtt 4140 gtaaatcacc cagtcataac aaggtcgcag tgcatggtgt tgcacaatat cttttagaag 4200 taggctgatt gccacagata agcccttggt gtaggtgttt acaaaccggt tgagctggga 4260 tgggtgcatt cggggtgaaa ttatgtgcat tttggattgg atttttaagt tggcaatatt 4320 gccgccaaga tcccgtcttg ggttcatgtt atgaaggacc accaagacgg tgtatccggt 4380 acatttagga aatttatcgt gcagcttgga tggaaaagcg tggaaaaatt tggagacacc 4440 cttgtgtcct ccaagatttt ccatgcactc atccatgata atagcaatgg ggccgtgggc 4500 agcggcgcgg gcaaacacgt tccgtgggtc tgacacatca tagttatgtt cctgagttaa 4560 atcatcataa gccattttaa tgaatttggg gcggagagta ccagattggg gtatgaatgt 4620 tccttcgggc cccggagcat agttcccctc acagatttgc atttcccaag ctttcagttc 4680 cgagggtgga atcatgtcca cctggggggc tatgaaaaac accgtttctg gggcgggggt 4740 gattaattgt gatgatagca aatttctgag caattgagat ttgccacatc cggtggggcc 4800 ataaatgatt ccgattacgg gttgcaggtg gtagtttagg gaacggcaac tgccgtcttc 4860 tcgaagcaag ggggccacct cgttcatcat ttcccttaca tgcatatttt cccgcaccaa 4920 atccattagg aggcgctctc ctcctagtga tagaagttct tgtagtgagg aaaagttttt 4980 cagcggtttc agaccgtcag ccatgggcat tttggagaga gtttgctgca aaagttctag 5040 tctgttccac agttcagtga tgtgttctat ggcatctcga tccagcagac ctcctcgttt 5100 cgcgggtttg gacggctcct ggaatagggt atgagacgat gggcgtccag cgctgccagg 5160 gttcggtcct tccagggtct cagtgttcga gtcagggttg tttccgtcac agtgaagggg 5220 tgtgcgcctg cttgggcgct tgccagggtg cgcttcagac tcatcctgct ggtcgaaaac 5280 ttctgtcgct tggcgccctg tatgtcggcc aagtagcagt ttaccatgag ttcgtagttg 5340 agcgcctcgg ctgcgtggcc tttggcgcgg agcttacctt tggaagtttt cttgcatacc 5400 gggcagtata ggcatttcag cgcatacaac ttgggcgcaa ggaaaacgga ttctggggag 5460 tatgcatctg cgccgcagga ggcgcaaaca gtttcacatt ccaccagcca ggttaaatcc 5520 ggttcattgg ggtcaaaaac aagttttccg ccatattttt tgatgcgttt cttacctttg 5580 gtctccatga gttcgtgtcc tcgttgagtg acaaacaggc tgtccgtgtc cccgtagact 5640 gattttacag gcctcttctc cagtggagtg cctcggtctt cttcgtacag gaactctgac 5700 cactctgata caaaggcgcg cgtccaggcc agcacaaagg aggctatgtg ggaggggtag 5760 cgatcgttgt caaccagggg gtccaccttt tccaaagtat gcaaacacat gtcaccctct 5820 tcaacatcca ggaatgtgat tggcttgtag gtgtatttca cgtgacctgg ggtccccgct 5880 gggggggtat aaaagggggc ggttctttgc tcttcctcac tgtcttccgg atcgctgtcc 5940 aggaacgtca gctgttgggg taggtattcc ctctcgaagg cgggcatgac ctctgcactc 6000 aggttgtcag tttctaagaa cgaggaggat ttgatattga cagtgccggt tgagatgcct 6060 ttcatgaggt tttcgtccat ttggtcagaa aacacaattt ttttattgtc aagtttggtg 6120 gcaaatgatc catacagggc gttggataaa agtttggcaa tggatcgcat ggtttggttc 6180 ttttccttgt ccgcgcgctc tttggcggcg atgttgagtt ggacatactc gcgtgccagg 6240 cacttccatt cggggaagat agttgttaat tcatctggca cgattctcac ttgccaccct 6300 cgattatgca aggtaattaa atccacactg gtggccacct cgcctcgaag gggttcattg 6360 gtccaacaga gcctacctcc tttcctagaa cagaaagggg gaagtgggtc tagcataagt 6420 tcatcgggag ggtctgcatc catggtaaag attcccggaa gtaaatcctt atcaaaatag 6480 ctgatgggag tggggtcatc taaggccatt tgccattctc gagctgccag tgcgcgctca 6540 tatgggttaa ggggactgcc ccatggcatg ggatgggtga gtgcagaggc atacatgcca 6600 cagatgtcat agacgtagat gggatcctca aagatgccta tgtaggttgg atagcatcgc 6660 ccccctctga tacttgctcg cacatagtca tatagttcat gtgatggcgc tagcagcccc 6720 ggacccaagt tggtgcgatt gggtttttct gttctgtaga cgatctggcg aaagatggcg 6780 tgagaattgg aagagatggt gggtctttga aaaatgttga aatgggcatg aggtagacct 6840 acagagtctc tgacaaagtg ggcataagat tcttgaagct tggttaccag ttcggcggtg 6900 acaagtacgt ctagggcgca gtagtcaagt gtttcttgaa tgatgtcata acctggttgg 6960 tttttctttt cccacagttc gcggttgaga aggtattctt cgcgatcctt ccagtactct 7020 tctagcggaa acccgtcttt gtctgcacgg taagatccta gcatgtagaa ctgattaact 7080 gccttgtaag ggcagcagcc cttctctacg ggtagagagt atgcttgagc agcttttcgt 7140 agcgaagcgt gagtaagggc aaaggtgtct ctgaccatga ctttgagaaa ttggtatttg 7200 aagtcgatgt cgtcacaggc tccctgttcc cagagttgga agtctacccg tttcttgtag 7260 gcggggttgg gcaaagcgaa agtaacatca ttgaagagaa tcttaccggc tctgggcata 7320 aaattgcgag tgatgcgaaa aggctgtggt acttccgctc gattgttgat cacctgggca 7380 gctaggacga tctcgtcgaa accgttgatg ttgtgtccta cgatgtataa ttctatgaaa 7440 cgcggcgtgc ctctgacgtg aggtagctta ctgagctcat caaaggttag gtctgtgggg 7500 tcagataagg cgtagtgttc gagagcccat tcgtgcaggt gaggatttgc atgtaggaat 7560 gatgaccaaa gatctaccgc cagtgctgtt tgtaactggt cccgatactg acgaaaatgc 7620 cggccaattg ccattttttc tggagtgaca cagtagaagg ttctggggtc ttgttgccat 7680 cgatcccact tgagtttaat ggctagatcg tgggccatgt tgacgagacg ctcttctcct 7740 gagagtttca tgaccagcat gaaaggaact agttgtttgc caaaggatcc catccaggtg 7800 taagtttcca catcgtaggt caggaagagt ctttctgtgc gaggatgaga gccgatcggg 7860 aagaactgga tttcctgcca ccagttggag gattggctgt tgatgtgatg gaagtagaag 7920 tttctgcggc gcgccgagca ttcgtgtttg tgcttgtaca gacggccgca gtagtcgcag 7980 cgttgcacgg gttgtatctc gtgaatgagt tgtacctggc ttcccttgac gagaaatttc 8040 agtgggaagc cgaggcctgg cgattgtatc tcgtgctctt ctatattcgc tgtatcggcc 8100 tgttcatctt ctgtttcgat ggtggtcatg ctgacgagcc cccgcgggag gcaagtccag 8160 acctcggcgc gggaggggcg gagctgaagg acgagagcgc gcaggctgga gctgtccaga 8220 gtcctgagac gctgcggact caggttagta ggtagggaca gaagattaac ttgcatgatc 8280 ttttccaggg cgtgcgggag gttcagatgg tacttgattt ccacaggttc gtttgtagag 8340 acgtcaatgg cttgcagggt tccgtgtcct ttgggcgcca ctaccgtacc tttgtttttt 8400 cttttgatcg gtggtggctc tcttgcttct tgcatgctca gaagcggtga cggggacgcg 8460 cgccgggcgg cagcggttgt tccggacccg agggcatggc tggtagtggc acgtcggcgc 8520 cgcgcacggg caggttctgg tactgcgctc tgagaagact tgcgtgcgcc accacgcgtc 8580 gattgacgtc ttgtatctga cgtctctggg tgaaagctac cggccccgtg agcttgaacc 8640 tgaaagagag ttcaacagaa tcaatttcgg tatcgttaac ggcagcttgt ctcagtattt 8700 cttgtacgtc accagagttg tcctggtagg cgatctccgc catgaactgc tcgatttctt 8760 cctcctgaag atctccgcga cccgctcttt cgacggtggc cgcgaggtca ttggagatac 8820 ggcccatgag ttgggagaat gcattcatgc ccgcctcgtt ccagacgcgg ctgtaaacca 8880 cggccccctc ggagtctctt gcgcgcatca ccacctgagc gaggttaagc tccacgtgtc 8940 tggtgaagac cgcatagttg cataggcgct gaaaaaggta gttgagtgtg gtggcaatgt 9000 gttcggcgac gaagaaatac atgatccatc gtctcagcgg catttcgcta acatcgccca 9060 gagcttccaa gcgctccatg gcctcgtaga agtccacggc aaaattaaaa aactgggagt 9120 ttcgcgcgga cacggtcaat tcctcctcga gaagacggat gagttcggct atggtggccc 9180 gtacttcgcg ttcgaaggct cccgggatct cttcttcctc ttctatctct tcttccacta 9240 acatctcttc ttcgtcttca ggcgggggcg gagggggcac gcggcgacgt cgacggcgca 9300 cgggcaaacg gtcgatgaat cgttcaatga cctctccgcg gcggcggcgc atggtttcag 9360 tgacggcgcg gccgttctcg cgcggtcgca gagtaaaaac accgccgcgc atctccttaa 9420 agtggtgact gggaggttct ccgtttggga gggagagggc gctgattata cattttatta 9480 attggcccgt agggactgca cgcagagatc tgatcgtgtc aagatccacg ggatctgaaa 9540 acctttcgac gaaagcgtct aaccagtcac agtcacaagg taggctgagt acggcttctt 9600 gtgggcgggg gtggttatgt gttcggtctg ggtcttctgt ttcttcttca tctcgggaag 9660 gtgagacgat gctgctggtg atgaaattaa agtaggcagt tctaagacgg cggatggtgg 9720 cgaggagcac caggtctttg ggtccggctt gctggatacg caggcgattg gccattcccc 9780 aagcattatc ctgacatcta gcaagatctt tgtagtagtc ttgcatgagc cgttctacgg 9840 gcacttcttc ctcacccgtt ctgccatgca tacgtgtgag tccaaatccg cgcattggtt 9900 gtaccagtgc caagtcagct acgactcttt cggcgaggat ggcttgctgt acttgggtaa 9960 gggtggcttg aaagtcatca aaatccacaa agcggtggta agctcctgta ttaatggtgt 10020 aagcacagtt ggccatgact gaccagttaa ctgtctggtg accagggcgc acgagctcgg 10080 tgtatttaag gcgcgaatag gcgcgggtgt caaagatgta atcgttgcag gtgcgcacca 10140 gatactggta ccctataaga aaatgcggcg gtggttggcg gtagagaggc catcgttctg 10200 tagctggagc gccaggggcg aggtcttcca acataaggcg gtgatagccg tagatgtacc 10260 tggacatcca ggtgattcct gcggcggtag tagaagcccg aggaaactcg cgtacgcggt 10320 tccaaatgtt gcgtagcggc atgaagtagt tcattgtagg cacggtttga ccagtgaggc 10380 gcgcgcagtc attgatgctc tatagacacg gagaaaatga aagcgttcag cgactcgact 10440 ccgtagcctg gaggaacgtg aacgggttgg gtcgcggtgt accccggttc gagacttgta 10500 ctcgagccgg ccggagccgc ggctaacgtg gtattggcac tcccgtctcg acccagccta 10560 caaaaatcca ggatacggaa tcgagtcgtt ttgctggttt ccgaatggca gggaagtgag 10620 tcctattttt tttttttgcc gctcagatgc atcccgtgct gcgacagatg cgcccccaac 10680 aacagccccc ctcgcagcag cagcagcagc aatcacaaaa ggctgtccct gcaactactg 10740 caactgccgc cgtgagcggt gcgggacagc ccgcctatga tctggacttg gaagagggcg 10800 aaggactggc acgtctaggt gcgccttcac ccgagcggca tccgcgagtt caactgaaaa 10860 aagattctcg cgaggcgtat gtgccccaac agaacctatt tagagacaga agcggcgagg 10920 agccggagga gatgcgagct tcccgcttta acgcgggtcg tgagctgcgt cacggtttgg 10980 accgaagacg agtgttgcgg gacgaggatt tcgaagttga tgaaatgaca gggatcagtc 11040 ctgccagggc acacgtggct gcagccaacc ttgtatcggc ttacgagcag acagtaaagg 11100 aagagcgtaa cttccaaaag tcttttaata atcatgtgcg aaccctgatt gcccgcgaag 11160 aagttaccct tggtttgatg catttgtggg atttgatgga agctatcatt cagaacccta 11220 ctagcaaacc tctgaccgcc cagctgtttc tggtggtgca acacagcaga gacaatgagg 11280 ctttcagaga ggcgctgctg aacatcaccg aacccgaggg gagatggttg tatgatctta 11340 tcaacattct acagagtatc atagtgcagg agcggagcct gggcctggcc gagaaggtgg 11400 ctgccatcaa ttactcggtt ttgagcttgg gaaaatatta cgctcgcaaa atctacaaga 11460 ctccatacgt tcccatagac aaggaggtga agatagatgg gttctacatg cgcatgacgc 11520 tcaaggtctt gaccctgagc gatgatcttg gggtgtatcg caatgacaga atgcatcgcg 11580 cggttagcgc cagcaggagg cgcgagttaa gcgacaggga actgatgcac agtttgcaaa 11640 gagctctgac tggagctgga accgagggtg agaattactt cgacatggga gctgacttgc 11700 agtggcagcc tagtcgcagg gctctgagcg ccgcgacggc aggatgtgag cttccttaca 11760 tagaagaggc ggatgaaggc gaggaggaag agggcgagta cttggaagac tgatggcaca 11820 acccgtgttt tttgctagat ggaacagcaa gcaccggatc ccgcaatgcg ggcggcgctg 11880 cagagccagc cgtccggcat taactcctcg gacgattgga cccaggccat gcaacgtatc 11940 atggcgttga cgactcgcaa ccccgaagcc tttagacagc aaccccaggc caaccgtcta 12000 tcggccatca tggaagctgt agtgccttcc cgctctaatc ccactcatga gaaggtcctg 12060 gccatcgtga acgcgttggt ggagaacaaa gctattcgtc cagatgaggc cggactggta 12120 tacaacgctc tcttagaacg cgtggctcgc tacaacagta gcaatgtgca aaccaatttg 12180 gaccgtatga taacagatgt acgcgaagcc gtgtctcagc gcgaaaggtt ccagcgtgat 12240 gccaacctgg gttcgctggt ggcgttaaat gctttcttga gtactcagcc tgctaatgtg 12300 ccgcgtggtc aacaggatta tactaacttt ttaagcgctt tgagactgat ggtatcagaa 12360 gtacctcaga gcgaagtgta tcagtccggt cctgattact tctttcagac tagcagacag 12420 ggcttgcaga cggtaaatct gagccaagct tttaaaaacc ttaaaggttt gtggggagtg 12480 catgccccgg taggagaaag agcaaccgtg tctagcttgt taactccgaa ctcccgccta 12540 ttattactgt tggtagctcc tttcaccgac agcggtagca tcgaccgtaa ttcctatttg 12600 ggttacctac taaacctgta tcgcgaagcc atagggcaaa gtcaggtgga cgagcagacc 12660 tatcaagaaa ttacccaagt cagtcgcgct ttgggacagg aagacactgg cagtttggaa 12720 gccactctga acttcttgct taccaatcgg tctcaaaaga tccctcctca atatgctctt 12780 actgcggagg aggagaggat ccttagatat gtgcagcaga gcgtgggatt gtttctgatg 12840 caagaggggg caactccgac tgcagcactg gacatgacag cgcgaaatat ggagcccagc 12900 atgtatgcca gtaaccgacc tttcattaac aaactgctgg actacttgca cagagctgcc 12960 gctatgaact ctgattattt caccaatgcc atcttaaacc cgcactggct gcccccacct 13020 ggtttctaca cgggcgaata tgacatgccc gaccctaatg acggatttct gtgggacgac 13080 gtggacagcg atgttttttc acctctttct gatcatcgca cgtggaaaaa ggaaggcggc 13140 gatagaatgc attcttctgc atcgctgtcc ggggtcatgg gtgctaccgc ggctgagccc 13200 gagtctgcaa gtccttttcc tagtctaccc ttttctctac acagtgtacg tagcagcgaa 13260 gtgggtagaa taagtcgccc gagtttaatg ggcgaagagg agtatctaaa cgattccttg 13320 ctcagaccgg caagagaaaa aaatttccca aacaatggaa tagaaagttt ggtggataaa 13380 atgagtagat ggaagactta tgctcaggat cacagagacg agcctgggat catggggatt 13440 acaagtagag cgagccgtag acgccagcgc catgacagac agaggggtct tgtgtgggac 13500 gatgaggatt cggccgatga tagcagcgtg ctggacttgg gtgggagagg aaggggcaac 13560 ccgtttgctc atttgcgccc tcgcttgggt ggtatgttgt aaaaaaaaat aaaaaaaaaa 13620 ctcaccaagg ccatggcgac gagcgtacgt tcgttcttct ttattatctg tgtctagtat 13680 aatgaggcga gtcgtgctag gcggagcggt ggtgtatccg gagggtcctc ctccttcgta 13740 cgagagcgtg atgcagcagc agcaggcgac ggcggtgatg caatccccac tggaggctcc 13800 ctttgtgcct ccgcgatacc tggcacctac ggagggcaga aacagcattc gttattcgga 13860 actggcacct cagtacgata ccaccaggtt gtatctggtg gacaacaagt cggcggacat 13920 tgcttctctg aactatcaga atgaccacag caacttcttg accacggtgg tgcaaaacaa 13980 tgactttacc cctacggaag ccagcaccca gaccattaac tttgatgaac gatcgcggtg 14040 gggcggtcag ctaaagacca tcatgcatac taacatgcca aacgtgaacg agtatatgtt 14100 tagtaacaag ttcaaagcgc gtgtgatggt gtccagaaaa cctcccgacg gtgctgcagt 14160 tggggatact tatgatcaca agcaggatat tttgaaatat gagtggttcg agtttacttt 14220 gccagaaggc aacttttcag ttactatgac tattgatttg atgaacaatg ccatcataga 14280 taattacttg aaagtgggta gacagaatgg agtgcttgaa agtgacattg gtgttaagtt 14340 cgacaccagg aacttcaagc tgggatggga tcccgaaacc aagttgatca tgcctggagt 14400 gtatacgtat gaagccttcc atcctgacat tgtcttactg cctggctgcg gagtggattt 14460 taccgagagt cgtttgagca accttcttgg tatcagaaaa aaacagccat ttcaagaggg 14520 ttttaagatt ttgtatgaag atttagaagg tggtaatatt ccggccctct tggatgtaga 14580 tgcctatgag aacagtaaga aagaacaaaa agccaaaata gaagctgcta cagctgctgc 14640 agaagctaag gcaaacatag ttgccagcga ctctacaagg gttgctaacg ctggagaggt 14700 cagaggagac aattttgcgc caacacctgt tccgactgca gaatcattat tggccgatgt 14760 gtctgaagga acggacgtga aactcactat tcaacctgta gaaaaagata gtaagaatag 14820 aagctataat gtgttggaag acaaaatcaa cacagcctat cgcagttggt atctttcgta 14880 caattatggc gatcccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt 14940 cacctgcgga gcagagcagg tctactggtc gcttccagac atgatgaagg atcctgtcac 15000 tttccgctcc actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt 15060 cttctcaaag agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac 15120 ctcgcttacg cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc 15180 gcccaccatt accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc 15240 gttgcgcagc agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac 15300 ctgtccctac gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac 15360 tttctaaaaa aaaaaaaaat gtccattctt atctcgccca gtaataacac cggttggggt 15420 ctgcgcgctc caagcaagat gtacggaggc gcacgcaaac gttctaccca acatcctgtc 15480 cgtgttcgcg gacattttcg cgctccatgg ggcgccctca agggccgcac tcgcgttcga 15540 accaccgtcg atgatgtaat cgatcaggtg gttgccgacg cccgtaatta tactcctact 15600 gcgcctacat ctactgtgga tgcagttatt gacagtgtag tggctgacgc tcgcaactat 15660 gctcgacgta agagccggcg aaggcgcatt gccagacgcc accgagctac cactgccatg 15720 cgagccgcaa gagctctgct acgaagagct agacgcgtgg ggcgaagagc catgcttagg 15780 gcggccagac gtgcagcttc gggcgccagc gccggcaggt cccgcaggca agcagccgct 15840 gtcgcagcgg cgactattgc cgacatggcc caatcgcgaa gaggcaatgt atactgggtg 15900 cgtgacgctg ccaccggtca acgtgtaccc gtgcgcaccc gtccccctcg cacttagaag 15960 atactgagca gtctccgatg ttgtgtccca gcggcgagga tgtccaagcg caaatacaag 16020 gaagaaatgc tgcaggttat cgcacctgaa gtctacggcc aaccgttgaa ggatgaaaaa 16080 aaaccccgca aaatcaagcg ggttaaaaag gacaaaaaag aagaggaaga tggcgatgat 16140 gggctggcgg agtttgtgcg cgagtttgcc ccacggcgac gcgtgcaatg gcgtgggcgc 16200 aaagttcgac atgtgttgag acctggaact tcggtggtct ttacacccgg cgagcgttca 16260 agcgctactt ttaagcgttc ctatgatgag gtgtacgggg atgatgatat tcttgagcag 16320 gcggctgacc gattaggcga gtttgcttat ggcaagcgta gtagaataac ttccaaggat 16380 gagacagtgt cgataccctt ggatcatgga aatcccaccc ctagtcttaa accggtcact 16440 ttgcagcaag tgttacccgt aactccgcga acaggtgtta aacgcgaagg tgaagatttg 16500 tatcccacta tgcaactgat ggtacccaaa cgccagaagt tggaggacgt tttggagaaa 16560 gtaaaagtgg atccagatat tcaacctgag gttaaagtga gacccattaa gcaggtagcg 16620 cctggtctgg gggtacaaac tgtagacatt aagattccca ctgaaagtat ggaagtgcaa 16680 actgaacccg caaagcctac tgccacctcc actgaagtgc aaacggatcc atggatgccc 16740 atgcctatta caactgacgc cgccggtccc actcgaagat cccgacgaaa gtacggtcca 16800 gcaagtctgt tgatgcccaa ttatgttgta cacccatcta ttattcctac tcctggttac 16860 cgaggcactc gctactatcg cagccgaaac agtacctccc gccgtcgccg caagacacct 16920 gcaaatcgca gtcgtcgccg tagacgcaca agcaaaccga ctcccggcgc cctggtgcgg 16980 caagtgtacc gcaatggtag tgcggaacct ttgacactgc cgcgtgcgcg ttaccatccg 17040 agtatcatca cttaatcaat gttgccgctg cctccttgca gatatggccc tcacttgtcg 17100 ccttcgcgtt cccatcactg gttaccgagg aagaaactcg cgccgtagaa gagggatgtt 17160 gggacgcgga atgcgacgct acaggcgacg gcgtgctatc cgcaagcaat tgcggggtgg 17220 ttttttacca gccttaattc caattatcgc tgctgcaatt ggcgcgatac caggcatagc 17280 ttccgtggcg gttcaggcct cgcaacgaca ttgacattgg aaaaaaacgt ataaataaaa 17340 aaaaaaaaat acaatggact ctgacactcc tggtcctgtg actatgtttt cttagagatg 17400 gaagacatca atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc 17460 tggagcgaca tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg 17520 agcgggctta aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc 17580 agtacaggac aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc 17640 gatgggatag cttccggcat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa 17700 aagataaaca gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa 17760 gaaattcctc cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg 17820 ctggtgacgc gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc 17880 accactagac cgatagcccc aatggccacc ggggtgatga aaccttctca gttgcatcga 17940 cccgtcacct tggatttgcc ccctccccct gctgctactg ctgtacccgc ttctaagcct 18000 gtcgctgccc cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca 18060 aatgcgcact ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa 18120 cgccgtcgct gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg 18180 tgtcattaca cgccgtcaca gcagcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg 18240 agttactttc aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc 18300 cggacaggat gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga 18360 cacctacttc aatctgggaa ataagtttag aaatcccacc gtagcgccga cccacgatgt 18420 gaccaccgac cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa 18480 tacatactct tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat 18540 ggccagcacg ttctttgaca ttaggggtgt gttggacaga ggtcccagtt tcaaacccta 18600 ttctggtacg gcttacaact ccctggctcc taaaggcgct ccaaatacat ctcagtggat 18660 tgcagaaggt gtaaaaaata caactggtga ggaacacgta acagaagagg aaaccaatac 18720 tactacttac acttttggca atgctcctgt aaaagctgaa gctgaaatta caaaagaagg 18780 actcccagta ggtttggaag tttcagatga agaaagtaaa ccgatttatg ctgataaaac 18840 atatcagcca gaacctcagc tgggagatga aacttggact gaccttgatg gaaaaaccga 18900 aaagtatgga ggcagggctc tcaaacccga tactaagatg aaaccatgct acgggtcctt 18960 tgccaaacct actaatgtga aaggcggtca ggcaaaacaa aaaacaacgg agcagccaaa 19020 tcagaaagtc gaatatgata tcgacatgga gttttttgat gcggcatcgc agaaaacaaa 19080 cttaagtcct aaaattgtca tgtatgcaga aaatgtaaat ttggaaactc cagacactca 19140 tgtagtgtac aaacctggaa cagaagacac aagttccgaa gctaatttgg gacaacaatc 19200 tatgcccaac agacccaact acattggctt cagagataac tttattggac ttatgtacta 19260 taacagtact ggtaacatgg gggtgctggc tggtcaagcg tctcagttaa atgcagtggt 19320 tgacttgcag gacagaaaca cagaactttc ttaccaactc ttgcttgact ctctgggcga 19380 cagaaccaga tactttagca tgtggaatca ggctgtggac agttatgatc ctgatgtacg 19440 tgttattgaa aatcatggtg tggaagatga acttcccaac tactgttttc cactggacgg 19500 cataggtgtt ccaacaacca gttacaaatc aatagttcca aatggagaca atgcgcctaa 19560 ttggaaggaa cctgaagtaa atggaacaag tgagatcgga cagggtaatt tgtttgccat 19620 ggaaattaac cttcaagcca atctatggcg aagtttcctt tattccaatg tggctctata 19680 tctcccagac tcgtacaaat acaccccgtc caatgtcact cttccagaaa acaaaaacac 19740 ctacgactac atgaacgggc gggtggtgcc gccatctcta gtagacacct atgtgaacat 19800 tggtgccagg tggtctctgg atgccatgga caatgtcaac ccattcaacc accaccgtaa 19860 cgctggcttg cgttaccgat ccatgcttct gggtaacgga cgttatgtgc ctttccacat 19920 acaagtgcct caaaaattct tcgctgttaa aaacctgctg cttctcccag gctcctacac 19980 ttatgagtgg aactttagga aggatgtgaa catggttcta cagagttccc tcggtaacga 20040 cctgcgggta gatggcgcca gcatcagttt cacgagcatc aacctctatg ctactttttt 20100 ccccatggct cacaacaccg cttccaccct tgaagccatg ctgcggaatg acaccaatga 20160 tcagtcattc aacgactacc tatctgcagc taacatgctc taccccattc ctgccaatgc 20220 aaccaatatt cccatttcca ttccttctcg caactgggcg gctttcagag gctggtcatt 20280 taccagactg aaaaccaaag aaactccctc tttggggtct ggatttgacc cctactttgt 20340 ctattctggt tctattccct acctggatgg taccttctac ctgaaccaca cttttaagaa 20400 ggtttccatc atgtttgact cttcagtgag ctggcctgga aatgacaggt tactatctcc 20460 taacgaattt gaaataaagc gcactgtgga tggcgaaggc tacaacgtag cccaatgcaa 20520 catgaccaaa gactggttct tggtacagat gctcgccaac tacaacatcg gctatcaggg 20580 cttctacatt ccagaaggat acaaagatcg catgtattca tttttcagaa acttccagcc 20640 catgagcagg caggtggttg atgaggtcaa ttacaaagac ttcaaggccg tcgccatacc 20700 ctaccaacac aacaactctg gctttgtggg ttacatggct ccgaccatgc gccaaggtca 20760 accctatccc gctaactatc cctatccact cattggaaca actgccgtaa atagtgttac 20820 gcagaaaaag ttcttgtgtg acagaaccat gtggcgcata ccgttctcga gcaacttcat 20880 gtctatgggg gcccttacag acttgggaca gaatatgctc tatgccaact cagctcatgc 20940 tctggacatg acctttgagg tggatcccat ggatgagccc accctgcttt atcttctctt 21000 cgaagttttc gacgtggtca gagtgcatca gccacaccgc ggcatcatcg aggcagtcta 21060 cctgcgtaca ccgttctcgg ccggtaacgc taccacgtaa gaagcttctt gcttcttgca 21120 aatagcagct gcaaccatgg cctgcggatc ccaaaacggc tccagcgagc aagagctcag 21180 agccattgtc caagacctgg gttgcggacc ctattttttg ggaacctacg ataagcgctt 21240 cccggggttc atggcccccg ataagctcgc ctgtgccatt gtaaatacgg ccggacgtga 21300 gacgggggga gagcactggt tggctttcgg ttggaaccca cgttctaaca cctgctacct 21360 ttttgatcct tttggattct cggatgatcg tctcaaacag atttaccagt ttgaatatga 21420 gggtctcctg cgccgcagcg ctcttgctac caaggaccgc tgtattacgc tggaaaaatc 21480 tacccagacc gtgcagggtc cccgttctgc cgcctgcgga cttttctgct gcatgttcct 21540 tcacgccttt gtgcactggc ctgaccgtcc catggacgga aaccccacca tgaaattgct 21600 aactggagtg ccaaacaaca tgcttcattc tcctaaagtc cagcccaccc tgtgtgacaa 21660 tcaaaaagca ctctaccatt ttcttaatac ccattcgcct tattttcgct cccatcgtac 21720 acacatcgaa agggccactg cgttcgaccg tatggatgtt caataatgac tcatgtaaac 21780 aacgtgttca ataaacatca ctttattttt ttacatgtat caaggctctg cattacttat 21840 ttatttacaa gtcgaatggg ttctgacgag aatcagaatg acccgcaggc agtgatacgt 21900 tgcggaactg atacttgggt tgccacttga attcgggaat caccaacttg ggaaccggta 21960 tatcgggcag gatgtcactc cacagctttc tggtcagctg caaagctcca agcaggtcag 22020 gagccgaaat cttgaaatca caattaggac cagtgctttg agcgcgagag ttgcggtaca 22080 ccggattgca gcactgaaac accatcagcg acggatgtct cacgcttgcc agcacggtgg 22140 gatctgcaat catgcccaca tccagatctt cagcattggc aatgctgaac ggggtcatct 22200 tgcaggtctg cctacccatg gcgggcaccc aattaggctt gtggttgcaa tcgcagtgca 22260 gggggatcag tatcatcttg gcctgatcct gtctgattcc tggatacacg gctctcatga 22320 aagcatcata ttgcttgaaa gcctgctggg ctttactacc ctcggtataa aacatcccgc 22380 aggacctgct cgaaaactgg ttagctgcac agccggcatc attcacacag cagcgggcgt 22440 cattgttagc tatttgcacc acacttctgc cccagcggtt ttgggtgatt ttggttcgct 22500 cgggattctc ctttaaggct cgttgtccgt tctcgctggc cacatccatc tcgataatct 22560 gctccttctg aatcataata ttgccatgca ggcacttcag cttgccctca taatcattgc 22620 agccatgagg ccacaacgca cagcctgtac attcccaatt atggtgggcg atctgagaaa 22680 aagaatgtat cattccctgc agaaatcttc ccatcatcgt gctcagtgtc ttgtgactag 22740 tgaaagttaa ctggatgcct cggtgctcct cgtttacgta ctggtgacag atgcgcttgt 22800 attgttcgtg ttgctcaggc attagtttaa aagaggttct aagttcgtta tccagcctgt 22860 acttctccat cagcagacac atcacttcca tgcctttctc ccaagcagac accaggggca 22920 agctaatcgg attcttaaca gtgcaggcag cagctccttt agccagaggg tcatctttag 22980 cgatcttctc aatgcttctt ttgccatcct tctcaacgat gcgcacgggc gggtagctga 23040 aacccactgc tacaagttgc gcctcttctc tttcttcttc gctgtcttga ctgatgtctt 23100 gcatggggat atgtttggtc ttccttggct tctttttggg gggtatcgga ggaggaggac 23160 tgtcgctccg ttccggagac agggaggatt gtgacgtttc gctcaccatt accaactgac 23220 tgtcggtaga agaacctgac cccacacggc gacaggtgtt tctcttcggg ggcagaggtg 23280 gaggcgattg cgaagggctg cggtccgacc tggaaggcgg atgactggca gaaccccttc 23340 cgcgttcggg ggtgtgctcc ctgtggcggt cgcttaactg atttccttcg cggctggcca 23400 ttgtgttctc ctaggcagag aaacaacaga catggaaact cagccattgc tgtcaacatc 23460 gccacgagtg ccatcacatc tcgtcctcag cgacgaggaa aaggagcaga gcttaagcat 23520 tccaccgccc agtcctgcca ccacctctac cctagaagat aaggaggtcg acgcatctca 23580 tgacatgcag aataaaaaag cgaaagagtc tgagacagac atcgagcaag acccgggcta 23640 tgtgacaccg gtggaacacg aggaagagtt gaaacgcttt ctagagagag aggatgaaaa 23700 ctgcccaaaa caacgagcag ataactatca ccaagatgct ggaaataggg atcagaacac 23760 cgactacctc atagggcttg acggggaaga cgcgctcctt aaacatctag caagacagtc 23820 gctcatagtc aaggatgcat tattggacag aactgaagtg cccatcagtg tggaagagct 23880 cagccgcgcc tacgagctta acctcttttc acctcgtact ccccccaaac gtcagccaaa 23940 cggcacctgc gagccaaatc ctcgcttaaa cttttatcca gcttttgctg tgccagaagt 24000 actggctacc tatcacatct tttttaaaaa tcaaaaaatt ccagtctcct gccgcgctaa 24060 tcgcacccgc gccgatgccc tactcaatct gggacctggt tcacgcttac ctgatatagc 24120 ttccttggaa gaggttccaa agatcttcga gggtctgggc aataatgaga ctcgggccgc 24180 aaatgctctg caaaagggag aaaatggcat ggatgagcat cacagcgttc tggtggaatt 24240 ggaaggcgat aatgccagac tcgcagtact caagcgaagc atcgaggtca cacacttcgc 24300 atatcccgct gtcaacctgc cccctaaagt catgacggcg gtcatggacc agttactcat 24360 taagcgcgca agtccccttt cagaagacat gcatgaccca gatgcctgtg atgagggtaa 24420 accagtggtc agtgatgagc agctaacccg atggctgggc accgactctc ccagggattt 24480 ggaagagcgt cgcaagctta tgatggccgt ggtgctggtt accgtagaac tagagtgtct 24540 ccgacgtttc tttaccgatt cagaaacctt gcgcaaactc gaagagaatc tgcactacac 24600 ttttagacac ggctttgtgc ggcaggcatg caagatatct aacgtggaac tcaccaacct 24660 ggtttcctac atgggtattc tgcatgagaa tcgcctagga caaagcgtgc tgcacagcac 24720 cctgaagggg gaagcccgcc gtgattacat ccgcgattgt gtctatctgt acctgtgcca 24780 cacgtggcaa accggcatgg gtgtatggca gcaatgttta gaagaacaga acttgaaaga 24840 gcttgacaag ctcttacaga aatctcttaa ggttctgtgg acagggttcg acgagcgcac 24900 cgtcgcttcc gacctggcag acctcatctt cccagagcgt ctcagggtta ctttgcgaaa 24960 cggattgcct gactttatga gccagagcat gcttaacaat tttcgctctt tcatcctgga 25020 acgctccggt atcctgcccg ccacctgctg cgcactgccc tccgactttg tgcctctcac 25080 ctaccgcgag tgccccccgc cgctatggag tcactgctac ctgttccgtc tggccaacta 25140 tctctcctac cactcggatg tgatcgagga tgtgagcgga gacggcttgc tggagtgtca 25200 ctgccgctgc aatctgtgca cgccccaccg gtccctagct tgcaaccccc agttgatgag 25260 cgaaacccag ataataggca cctttgaatt gcaaggcccc agcagccaag gcgatgggtc 25320 ttctcctggg caaagtttaa aactgacccc gggactgtgg acctccgcct acttgcgcaa 25380 gtttgctccg gaagattacc acccctatga aatcaagttc tatgaggacc aatcacagcc 25440 tccaaaggcc gaactttcgg cctgcgtcat cacccagggg gcaattctgg cccaattgca 25500 agccatccaa aaatcccgcc aagaatttct actgaaaaag ggtaaggggg tctaccttga 25560 cccccagacc ggcgaggaac tcaacacaag gttccctcag gatgtcccaa cgacgagaaa 25620 acaagaagtt gaaggtgcag ccgccgcccc cagaagatat ggaggaagat tgggacagtc 25680 aggcagagga ggcggaggag gacagtctgg aggacagtct ggaggaagac agtttggagg 25740 aggaaaacga ggaggcagag gaggtggaag aagtaaccgc cgacaaacag ttatcctcgg 25800 ctgcggagac aagcaacagc gctaccatct ccgctccgag tcgaggaacc cggcggcgtc 25860 ccagcagtag atgggacgag accggacgct tcccgaaccc aaccagcgct tccaagaccg 25920 gtaagaagga tcggcaggga tacaagtcct ggcgggggca taagaatgcc atcatctcct 25980 gcttgcatga gtgcgggggc aacatatcct tcacgcggcg ctacttgcta ttccaccatg 26040 gggtgaactt tccgcgcaat gttttgcatt actaccgtca cctccacagc ccctactata 26100 gccagcaaat cccggcagtc tcgacagata aagacagcgg cggcgacctc caacagaaaa 26160 ccagcagcgg cagttagaaa atacacaaca agtgcagcaa caggaggatt aaagattaca 26220 gccaacgagc cagcgcaaac ccgagagtta agaaatcgga tctttccaac cctgtatgcc 26280 atcttccagc agagtcgggg tcaagagcag gaactgaaaa taaaaaaccg atctctgcgt 26340 tcgctcacca gaagttgttt gtatcacaag agcgaagatc aacttcagcg cactctcgag 26400 gacgccgagg ctctcttcaa caagtactgc gcgctgactc ttaaagagta ggcagcgacc 26460 gcgcttattc aaaaaaggcg ggaattacat catcctcgac atgagtaaag aaattcccac 26520 gccttacatg tggagttatc aaccccaaat gggattggcg gcaggcgcct cccaggacta 26580 ctccacccgc atgaattggc tcagcgccgg gccttctatg atttctcgag ttaatgatat 26640 acgcgcctac cgaaaccaaa tacttttgga acagtcagct cttaccacca cgccccgcca 26700 acaccttaat cccagaaatt ggcccgccgc cctagtgtac caggaaagtc ccgctcccac 26760 cactgtatta cttcctcgag acgcccaggc cgaagtccaa atgactaatg caggtgcgca 26820 gttagctggc ggctccaccc tatgtcgtca caggcctcgg cataatataa aacgcctgat 26880 gatcagaggc cgaggtatcc agctcaacga cgagtcggtg agctctccgc ttggtctacg 26940 accagacgga atctttcaga ttgccggctg cgggagatct tccttcaccc ctcgtcaggc 27000 tgttctgact ttggaaagtt cgtcttcgca accccgctcg ggcggaatcg ggaccgttca 27060 atttgtggag gagtttactc cctctgtcta cttcaacccc ttctccggat ctcctgggca 27120 ttacccggac gagttcatac cgaacttcga cgcgattagc gagtcagtgg acggctacga 27180 ttgatgtctg gtgacgcggc tgagctatct cggctgcgac atctagacca ctgccgccgc 27240 tttcgctgct ttgcccggga actcattgag ttcatctact tcgaactccc caaggatcac 27300 cctcaaggtc cggcccacgg agtgcggatt tctatcgaag gcaaaataga ctctcgcctg 27360 caacgaattt tctcccagcg gcccgtgctg atcgagcgag accagggaaa caccacggtt 27420 tccatctact gcatttgtaa tcaccccgga ttgcatgaaa gcctttgctg tcttatgtgt 27480 actgagttta ataaaaactg aattaagact ctcctacgga ctgccgcttc ttcaacccgg 27540 attttacaac cagaagaacg aaacttttcc tgtcgtccag gactctgtta acttcacctt 27600 tcctactcac aaactagaag ctcaacgact acaccgcttt tccagaagca ttttccctac 27660 taatactact ttcaaaaccg gaggtgagct ccaaggtctt cctacagaaa acccttgggt 27720 ggaagcgggc cttgtagtgc taggaattct tgcgggtggg cttgtgatta ttctttgcta 27780 cctatacaca ccttgcttca ctttcttagt ggtgttgtgg tattggttta aaaaatgggg 27840 cccatactag tcttgcttgt tttactttcg cttttggaac cgggttctgc caattacgat 27900 ccatgtctag acttcgaccc agaaaactgc acacttactt ttgcacccga cacaagccgc 27960 atctgtggag ttcttattaa gtgcggatgg gaatgcaggt ccgttgaaat tacacacaat 28020 aacaaaacct ggaacaatac cttatccacc acatgggagc caggagttcc cgagtggtac 28080 actgtctctg tccgaggtcc tgacggttcc atccgcatta gtaacaacac tttcattttt 28140 tctgaaatgt gcgatctggc catgttcatg agcaaacagt attctctatg gcctcctagc 28200 aaggacaaca tcgtaacgtt ctccattgct tattgcttgt gcgcttgcct tcttactgct 28260 ttactgtgcg tatgcataca cctgcttgta accactcgca tcaaaaacgc caataacaaa 28320 gaaaaaatgc cttaacctct ttctgtttac agacatggct tctcttacat ctctcatatt 28380 tgtcagcatt gtcactgccg ctcatggaca aacagtcgtc tctatccctc taggacataa 28440 ttacactctc ataggacccc caatcacttc agaggtcatc tggaccaaac tgggaagcgt 28500 tgattacttt gatataatct gcaacaaaac aaaaccaata atagtaactt gcaacataca 28560 aaatcttaca ttgattaatg ttagcaaagt ttacagcggt tactattatg gttatgacag 28620 atacagtagt caatatagaa attacttggt tcgtgttacc cagttgaaaa ccacgaaaat 28680 gccaaatatg gcaaagattc gatccgatga caattctcta gaaactttta catctcccac 28740 cacacccgac gaaaaaaaca tcccagattc aatgattgca attgttgcag cggtggcagt 28800 ggtgatggca ctaataataa tatgcatgct tttatatgct tgtcgctaca aaaagtttca 28860 tcctaaaaaa caagatctcc tactaaggct taacatttaa tttcttttta tacagccatg 28920 gtttccacta ccacattcct tatgcttact agtctcgcaa ctctgacttc tgctcgctca 28980 cacctcactg taactatagg ctcaaactgc acactaaaag gacctcaagg tggtcatgtc 29040 ttttggtgga gaatatatga caatggatgg tttacaaaac catgtgacca acctggtaga 29100 tttttctgca acggcagaga cctaaccatt atcaacgtga cagcaaatga caaaggcttc 29160 tattatggaa ccgactataa aagtagttta gattataaca ttattgtact gccatctacc 29220 actccagcac cccgcacaac tactttctct agcagcagtg tcgctaacaa tacaatttcc 29280 aatccaacct ttgccgcgct tttaaaacgc actgtgaata attctacaac ttcacataca 29340 acaatttcca cttcaacaat cagcattatc gctgcagtga caattggaat atctattctt 29400 gtttttacca taacctacta cgcctgctgc tatagaaaag acaaacataa aggtgatcca 29460 ttacttagat ttgatattta atttgttctt ttttttttta tttacagtat ggtgaacacc 29520 aatcatggta cctagaaatt tcttcttcac catactcatt tgtgcattta atgtttgcgc 29580 tactttcaca gcagtagcca cagcaacccc agactgtata ggagcatttg cttcctatgc 29640 actttttgct tttgttactt gcatctgcgt atgtagcata gtctgcctgg ttattaattt 29700 tttccaactt atagactgga tccttgtgcg aattgcctac ctgcgccacc atcccgaata 29760 ccgcaaccaa aatatcgcgg cacttcttag actcatctaa aaccatgcag gctatactac 29820 caatattttt gcttctattg cttccctacg ctgtctcaac cccagctgcc tatagtactc 29880 caccagaaca ccttagaaaa tgcaaattcc aacaaccgtg gtcatttctt gcttgctatc 29940 gagaaaaatc agaaattccc ccaaatttaa taatgattgc tggaataatt aatataatct 30000 gttgcaccat aatttcattt ttgatatacc ccctatttga ttttggctgg aatgctccca 30060 atgcacatga tcatccacaa gacccagagg aacacattcc cctacaaaac atgcaacatc 30120 caatagcgct aatagattac gaaagtgaac cacaaccccc actactccct gctattagtt 30180 acttcaacct aaccggcgga gatgactgaa acactcacca cctccaattc cgccgaggat 30240 ctgctcgata tggacggccg cgtctcagaa cagcgactcg cccaactacg catccgccag 30300 cagcaggaac gcgcggccaa agagctcaga gatgtcatcc aaattcacca atgcaaaaaa 30360 ggcatattct gtttggtaaa acaagccaag atatcctacg agatcaccgc tactgaccat 30420 cgcctctctt acgaacttgg cccccaacga caaaaattta cctgcatggt gggaatcaac 30480 cccatagtta tcacccagca aagtggagat actaagggtt gcattcactg ctcctgcgat 30540 tccatcgagt gcacctacac cctgctgaag accctatacg gcctaagaga cctgctacca 30600 atgaattaaa aaatgattaa taaaaaatca cttacttgaa atcagcaata aggtctctgt 30660 tgaaattttc tcccagcagc acctcacttc cctcttccca actctggtat tctaaacccc 30720 gttcagcggc atactttctc catactttaa aggggatgtc aaattttagc tcctctcctg 30780 tacccacaat cttcatgtct ttcttcccag atgaccaaga gagtccggct cagtgactcc 30840 ttcaaccctg tctaccccta tgaagatgaa agcacctccc aacacccctt tataaaccca 30900 gggtttattt ccccaaatgg cttcacacaa agcccaaacg gagttcttac tttaaaatgt 30960 ttaaccccac taacaaccac aggcggatct ctacagctaa aagtgggagg gggacttaca 31020 gtggatgaca ccaacggttt tttgaaagaa aacataagtg ccaccacacc actcgttaag 31080 actggtcact ctataggttt accactagga gccggattgg gaacgaatga aaataaactt 31140 tgtatcaaat taggacaagg acttacattc aattcaaaca acatttgcat tgatgacaat 31200 attaacacct tatggacagg agtcaacccc accgaagcca actgtcaaat catgaactcc 31260 agtgaatcta atgattgcaa attaattcta acactagtta aaactggagc actagtcact 31320 gcatttgttt atgttatagg agtatctaac aattttaata tgctaactac acacagaaat 31380 ataaatttta ctgcagagct gtttttcgat tctactggta atttactaac tagactctca 31440 tccctcaaaa ctccacttaa tcataaatca ggacaaaaca tggctactgg tgccattact 31500 aatgctaaag gtttcatgcc cagcacgact gcctatcctt tcaatgataa ttctagagaa 31560 aaagaaaact acatttacgg aacttgttac tacacagcta gtgatcgcac tgcttttccc 31620 attgacatat ctgtcatgct taaccgaaga gcaataaatg acgagacatc atattgtatt 31680 cgtataactt ggtcctggaa cacaggagat gccccagagg tgcaaacctc tgctacaacc 31740 ctagtcacct ccccatttac cttttactac atcagagaag acgactgaca aataaagttt 31800 aacttgttta tttgaaaatc aattcacaaa atccgagtag ttattttgcc tcccccttcc 31860 catttaacag aatacaccaa tctctcccca cgcacagctt taaacatttg gataccatta 31920 gatatagaca tggttttaga ttccacattc caaacagttt cagagcgagc caatctgggg 31980 tcagtgatag ataaaaatcc atcgggatag tcttttaaag cgctttcaca gtccaactgc 32040 tgcggatgcg actccggagt ctggatcacg gtcatctgga agaagaacga tgggaatcat 32100 aatccgaaaa cggtatcgga cgattgtgtc tcatcaaacc cacaagcagc cgctgtctgc 32160 gtcgctccgt gcgactgctg tttatgggat cagggtccac agtgtcctga agcatgattt 32220 taatagccct taacatcaac tttctggtgc gatgcgcgca gcaacgcatt ctgatttcac 32280 tcaaatcttt gcagtaggta caacacatta ttacaatatt gtttaataaa ccataattaa 32340 aagcgctcca gccaaaactc atatctgata taatcgcccc tgcatgacca tcataccaaa 32400 gtttaatata aattaaatga cgttccctca aaaacacact acccacatac atgatctctt 32460 ttggcatgtg catattaaca atctgtctgt accatggaca acgttggtta atcatgcaac 32520 ccaatataac cttccggaac cacactgcca acaccgctcc cccagccatg cattgaagtg 32580 aaccctgctg attacaatga caatgaagaa cccaattctc tcgaccgtga atcacttgag 32640 aatgaaaaat atctatagtg gcacaacata gacataaatg catgcatctt ctcataattt 32700 ttaactcctc aggatttaga aacatatccc agggaatagg aagctcttgc agaacagtaa 32760 agctggcaga acaaggaaga ccacgaacac aacttacact atgcatagtc atagtatcac 32820 aatctggcaa cagcgggtgg tcttcagtca tagaagctcg ggtttcattt tcctcacaac 32880 gtggtaactg ggctctggtg taagggtgat gtctggcgca tgatgtcgag cgtgcgcgca 32940 accttgtcat aatggagttg cttcctgaca ttctcgtatt ttgtatagca aaacgcggcc 33000 ctggcagaac acactcttct tcgccttcta tcctgccgct tagcgtgttc cgtgtgatag 33060 ttcaagtaca accacactct taagttggtc aaaagaatgc tggcttcagt tgtaatcaaa 33120 actccatcgc atctaatcgt tctgaggaaa tcatccacgg tagcatatgc aaatcccaac 33180 caagcaatgc aactggattg tgtttcaagc aggagaggag agggaagaga cggaagaacc 33240 atgttaattt ttattccaaa cgatctcgca gtacttcaaa ttgtagatcg cgcagatggc 33300 atctctcgcc cccactgtgt tggtgaaaaa gcacagctag atcaaaagaa atgcgatttt 33360 caaggtgctc aacggtggct tccagcaaag cctccacgcg cacatccaag aacaaaagaa 33420 taccaaaaga aggagcattt tctaactcct caatcatcat attacattcc tgcaccattc 33480 ccagataatt ttcagctttc cagccttgaa ttattcgtgt cagttcttgt ggtaaatcca 33540 atccacacat tacaaacagg tcccggaggg cgccctccac caccattctt aaacacaccc 33600 tcataatgac aaaatatctt gctcctgtgt cacctgtagc gaattgagaa tggcaacatc 33660 aattgacatg cccttggctc taagttcttc tttaagttct agttgtaaaa actctctcat 33720 attatcacca aactgcttag ccagaagccc cccgggaaca agagcagggg acgctacagt 33780 gcagtacaag cgcagacctc cccaattggc tccagcaaaa acaagattgg aataagcata 33840 ttgggaaccg ccagtaatat catcgaagtt gctggaaata taataaggca gagtttcttg 33900 taaaaattga ataaaagaaa aatttgccaa aaaaacattc aaaacctctg ggatgcaaat 33960 gcaataggtt accgcgctgc gctccaacat tgttagtttt gaattagtct gcaaaaataa 34020 aaaaaaaaac aagcgtcata tcatagtagc ctgacgaaca gatggataaa tcagtctttc 34080 catcacaaga caagccacag ggtctccagc tcgaccctcg taaaacctgt catcatgatt 34140 aaacaacagc accgaaagtt cctcgcggtg accagcatga ataattcttg atgaagcata 34200 caatccagac atgttagcat cagttaacga gaaaaaacag ccaacatagc ctttgggtat 34260 aattatgctt aatcgtaagt atagcaaagc cacccctcgc ggatacaaag taaaaggcac 34320 aggagaataa aaaatataat tatttctctg ctgctgttca ggcaacgtcg cccccggtcc 34380 ctctaaatac acatacaaag cctcatcagc catggcttac cagacaaagt acagcgggca 34440 cacaaagcac aagctctaaa gtgactctcc aacctctcca caatatatat atacacaagc 34500 cctaaactga cgtaatggga gtaaagtgta aaaaatcccg ccaaacccaa cacacacccc 34560 gaaactgcgt caccagggaa aagtacagtt tcacttccgc aatcccaaca ggcgtaactt 34620 cctctttctc acggtacgtg atatcccact aacttgcaac gtcattttcc cacggtcgca 34680 ccgccccttt tagccgttaa ccccacagcc aatcaccaca cgatccacac tttttaaaat 34740 cacctcattt acatattggc accattccat ctataaggta tattattgat gatg 34794 <210> 142 <211> 34125 <212> DNA <213> Human adenovirus A <400> 142 cctatctaat aatatacctt atactggact agtgccaata ttaaaatgaa gtgggcgtag 60 tgtgtaattt gattgggtgg aggtgtggct ttggcgtgct tgtaagtttg ggcggatgag 120 gaagtggggc gcggcgtggg agccgggcgc gccggatgtg acgttttaga cgccatttta 180 cacggaaatg atgttttttg ggcgttgttt gtgcaaattt tgtgttttag gcgcgaaaac 240 tgaaatgcgg aagtgaaaat tgatgacggc aattttatta taggcgcgga atatttaccg 300 agggcagagt gaactctgag cctctacgtg tgggtttcga tacgtgagcg acggggaaac 360 tccacgttgg cgctcaaagg gcgcgtttat tgttctgtca gctgatcgtt tgggtattta 420 atgccgccgt gttcgtcaag aggccactct tgagtgccag cgagaagagt tttctctgcc 480 agctcatttt cacggcgcca ttatgagaac tgaaatgact cccttggtcc tgtcgtatca 540 ggaagctgac gacatattgg agcatttggt ggacaacttt tttaacgagg tacccagtga 600 tgatgatctt tatgttccgt ctctttacga actgtatgat cttgatgtgg agtctgccgg 660 tgaagataat aatgaacagg cggtgaatga gttttttccc gaatcgctta ttttagctgc 720 cagtgagggg ttgtttttac cggagcctcc tgtactttct cctgtctgtg agcctattgg 780 gggcgaatgt atgccacaac tgcaccctga agatatggat ttattgtgct acgagatggg 840 ctttccctgt agcgattcgg aagacgagca agacgagaac ggaatggcgc atgtttctgc 900 atccgcagct gctgctgccg ctgataggga acgtgaggag tttcagttag accatccaga 960 gttgcccgga cacaattgta agtcctgtga gcaccaccgg aatagtactg gaaatactga 1020 cttaatgtgc tctttgtgct atctgcgagc ctacaacatg ttcatttaca gtaagtgtgc 1080 tatgggaggt gggaggtgat ttttttttct taagcagtga aaaataatat tttgttgttt 1140 ttaggtcctg tttccgataa tgagcctgaa cctaatagca ctttggatgg cgatgagcga 1200 ccctcacccc cgaaactagg aagtgcggtt ccagaaggag taataaaacc tgtgcctcag 1260 cgggtgactg ggaggcgtag atgtgctgtg gaaagcattt tggatttgat tcaagaggaa 1320 gaaagagaac aaacagtgcc tgttgatctg tcagtgaaac gccctagatg taattaatgg 1380 actttgagca cctgggcaat aaaatagggg taatgtggtt tttgtgagtc atgtataata 1440 aaactggttt cggttgaagt gtcttgttaa tgtttgtttg ggcgtggtta aacagggata 1500 taaagctggg ttggtgttgc tttgaatagt tcatcttagt aatggagttg gaaactgtgc 1560 tgcaaagttt tcagagcgtt cgccagctct tgcagtatac ctctaaaaac acttcaggtt 1620 tttggaggta tctgtttggc tctaccttaa gcaaggtggt aaatagggtg aaagaagact 1680 atagagagga atttgaaaac atattggccg actgtccagg gcttttggct tcactagacc 1740 tttgttacca cttggtgttt caggaaaaag tggtcagatc cttagatttt tcatctgtgg 1800 gacgaacggt tgcttctatt gcttttttgg caaccatatt ggataaatgg agcgagaaat 1860 cccacctgag ttgggattac atgctggatt acatgtcaat gcagctgtgg agggcatggc 1920 tgaagaggag ggtttgcatt tactcgctgg cgcggccttt gaccatgccg ccgctgccga 1980 cgttgcaaga ggagaaggag gaggagcgga accctgcggt ggtggagaag taaacatgga 2040 acaacaggtg caagaaggcc atgtacttga ctctggcgaa gggcctagtt gcgcagatga 2100 tagagataag caggaaaaaa aagaaagttt aaaggaagct gctgttctta gtaggctaac 2160 tgttaatctg atgtcccgcc cgcgtttgga aactgtatat tggcaggagt tgcaggatga 2220 atttcagcgg ggtgatatgc atttacagta caaatacagt tttgaacaat taaaaaccca 2280 ctggttagag ccatgggagg atatggagtg tgctattaaa gcttttgcta aattggcctt 2340 acgtcctgat tgtagctaca gaattactaa aacagtaacc attacttcat gcgcctatat 2400 tataggtaac ggggcaatag ttgaggtaga tacaagcgac agagttgctt ttagatgtcg 2460 aatgcagggt atgggcccag gggtggtggg tttggatgga attacattta taaatgttag 2520 gtttgctgga gataagttta aaggcattat gttcgaagct aatacctgtc ttgtcttgca 2580 tggtgtttac tttcttaact ttagtaacat ttgtgtagag tcttggaata aggtttctgc 2640 taggggctgt actttttatg gatgttggaa gggtttggtg ggtagaccaa aaagtaaact 2700 gtctgtaaaa aagtgtttgt ttgaaaaatg tgtacttgct ttaattgtag agggggatgc 2760 acatattagg cataatgcag cttcagaaaa tgcctgtttt gtattattga agggaatggc 2820 tattttaaag cataatatgg tttgtggggt gtctgatcaa actatgcgac gttttgttac 2880 ctgtgctgat ggaaattgtc ataccttaaa aactgttcat attgtgagcc acagtagaca 2940 ttgttggcct gtatgtgatc ataacatgtt tatgcgctgt accatacatt taggcttaag 3000 gcggggtatg tttagacctt cccaatgtaa cttcagccac tcaaacatta tgctggaacc 3060 tgaagtgttt tctagagtgt gtttaaatgg ggtatttgat ttatctgtgg aattatgtaa 3120 ggttataaga tataatgatg atactcgaca tcgttgccga cagtgtgagt gtggtagcag 3180 tcatctagaa cttcgtccca ttgtgctaaa tgtaactgag gagctgagaa gtgaccacct 3240 taccctgtct tgcctgcgga ctgactatga gtcaagtgat gaagacgaca actgaggtaa 3300 gtgggtggag ctaggtggga ttataaaagg ctggaagtca actaaaaatt gtttttgttc 3360 ttttaacagc acgatgaacg gaactactca gaacaacgct gcgctttttg atggaggggt 3420 ttttagccct tatttgactt ccaggttacc atattgggcc ggagtacgtc agaatgtggt 3480 aggatctaca gtggacggtc gacctgtggc acctgcaaat tcatcaacat taacctatgc 3540 aactattgga ccctcgcctt tggataccgc cgccgccgct gcagcttccg cggccgcttc 3600 tacggctcgc agtatggcag ctgatttcag cttctacaat cacttggctt cgaatgctgt 3660 gacacgcacc gcagttcgag aggacattct gactgttatg cttgccaagc ttgaaactct 3720 aactgctcag ctggaagagc tatcgcaaaa ggttgaggaa ttagctgatg ctactaccca 3780 taccccagcc caacctgtaa cccaataaag aaaaaactta aattgagatg gtgttatgaa 3840 tctttattga tacttgtttt ttctgacatg gtaagctctt gaccaccgtt ccctatcatt 3900 aagaacacgg tgaatgtgtt ccagtatttt gtaaagatga gcctgtatat taaggtacat 3960 tggcattagg ccatctttgg gatgaaggta ggaccattga agggcttcat gttccgggtt 4020 agtgttgtag ataatccagt catagcaaca acgctgggca tggtgattaa atatatcttt 4080 taacaacaag ctaattgcta atggaagacc tttagtatag gtattgataa aacggttaag 4140 ctgggtggga tgcatccgag gtgacatgat atgaagtttt gattgtattt tgagattggc 4200 aatgttacct gccaaatctc ttcttggatt catattgtgg agaaccacga aaacggtgta 4260 gccagtacac ttgggaaatt tgtcatggag tttagaagga aaggcatgga aaaacttgga 4320 aacgcctttg tgacttccca aattttccat acactcatcc attattatgg caattggacc 4380 gcgagcagcg gcttgagcaa aaatgttttc tggatcagaa acatcatagt tgtggtctag 4440 agttaggtca tcgtaggaca acttaacaaa tttaggacac agcgttccag attgtggaat 4500 aatagttccc tctggtcctg ggacataatt tccctcacaa atttgcattt cccaagattt 4560 aatttcagat gggggaatca tgtccacttg cggaacaata aaaaaaacag tttctggagc 4620 aggtgtaacc agctgggcag aaagcaaatt acgcaacaac tgagacttcc cacagccagt 4680 gggtccataa attaccccaa ttacaggttg caagtgatag tttaacgagg tgcagctgcc 4740 gtcttcgtgg agaagcggag ccacttcatt catcatttgt cggacgcgga tgttttgctt 4800 ggccagttcc cctaacagac gctctccgcc taaggaaagt aactcttgta aagatttgaa 4860 atttttaagt ggctttaggc catcggccat aggcatgtgg tccagggttt gcttcagcag 4920 ttgcaagcga tcccatagct cagttatatt ttctatgcca tctcgatcca gcaaacttcc 4980 tcgttgcggg ggtttggctg gctgttgctg taaggaacga ggcggtgagc atccaaatgg 5040 acgagggttt tgtccttcca gggacgtaat gtgcgcgtca gggttgtttc ggtcacggtg 5100 aatggatgcg ctcctggttg agcgctggcc agtgtgcgct ttaaactgag gcggctggtg 5160 ctgaagcgcg tgtcttctcc ctgtgcttcg gcaaggtagc attttaacat aagatcataa 5220 gacaaagcct ctgtagcgtg gcctttagcc cgtatttttc ctttggaggt gctcccgcag 5280 tgaggacact gaaggcattt aagggcgtac agttttggag ccaaaaaaac agattctgga 5340 gaataagcat ctgcgccaca ataactacaa acagtttcac attcaactga ccaggtcagc 5400 tcaggacatg atggatcaaa aacaagtttc cctccgtact ttttgatgcg tttcttacct 5460 tgcgactcca taaggcggcg tcctttctct gtgacaaaaa gactgtcagt gtctccgtat 5520 acagatttaa ggggtctatc cttcagtggt attccgcggt cctcctcgta caggaattct 5580 gaccactctg acacaaaagc tctagtccaa gcaagtacaa aggaagccac atgggaaggg 5640 taccgatcgt tgttaattaa agggttagaa ctttctaagg tgtgtaaaca catgtctcct 5700 tcttcagcgt ccatgaatgt gattggtttg taggtgtaag tcacgtgttc acaattttct 5760 ggtggtgggc tataaaaagg ggcgggtcct tggtcttcat cgctttcttc tgcttcgctg 5820 tttacgagcg ccaactggtt gggtgagtac acgcgctcaa aggcaggcat tacctctgta 5880 ctcaacgtgt cagtttctat aaacgatgag gatttgatgt ttaatcgccc cgctgcaatt 5940 tctttcatta ggctttcttc catttgatca gaaaaaacta tttttttgtt atctagtttg 6000 gtagcaaaag atccgtacaa ggcattggaa agcagcttgg ctatagatct tagggtttga 6060 tttttgtccc tatcggcccg ttcttttgcg gcaatattga gttgcacata ttcgcgtgcc 6120 aggcatttcc aggtggggaa aatggtggtg cgctcgtcag atagcaagcg taagcgccac 6180 ccgcgattat gcagtgtaac cagatctacg ctggtaacta cttcaccgcg caagctttca 6240 ttggtccagg ctaaacgacc gccttttcta gaacaaaaag gaggaagaac atccaactga 6300 ttttcatctg gggggtcggc atctatagta aaaatgccag gacaaagatt tttgtcaaaa 6360 taatcaattt tgcaagtgta attttccagc gccacctgcc attgccgcac ggccaatgcc 6420 cgctcatagg ggttaagggg aggaccccaa ggcatggggt gtgtgagggc cgatgcatac 6480 atgccgcaaa tatcatatac atatatgggc tcttttagta ctcctatgta agtaggatag 6540 cacctgccgc cacgaatgct ggcgcgaacg tagtcatata gctcatgtga aggcgccagg 6600 atgttgggcc caagatgtgt gcgctgtggt ttttcggcgc ggtacaaaat ttgtctgaaa 6660 attgcatgag agttagagga aatggtagga cgctgaaaca cattaaaatg tgccgcgtca 6720 agacccactg cgtcagtaac aaactgggcg tatgagctac gcagtttttc taccaatgag 6780 gcagtcacaa gtacatccag ggcacaatag tttaatgttt ccccgataag attgtaattt 6840 ttttctcctt tttttttcca tagttcttga tttaggaggt attcctcctt atccttccag 6900 tactcctcca ggggaaaccc atttgcatct gcacggtaag aaccaagcat ataaaactga 6960 tttaccgcct tgtacggaca acatcctttt tctacaggca gggcatacgc ttgtgcagcc 7020 tttcttaaag atgtatgagt aagagcaaag gtatctctga ccattacttt taaatactgg 7080 tatttaaaat cttggtcgtc acaccctccg tgttcccaca gtaggaagtt agttcgcttt 7140 ttgtagtggg gattgggaag ggcaaaagta atatcattaa ataatatttt gccagctctt 7200 ggaataaaat ttctagaaat tttaaagggt ccagggacgt ccaagcggtt attgattacc 7260 tgagcggcaa gaacaatttc atcaaatcca ttaatattgt gtcctactat atacaactct 7320 acaaatcttg gctcaccctt aattgcaggg gctcttttaa gatcttcgta ggaaagatct 7380 tcaagcgcga ctagtccgtt ttcttcttga gcccattgag acaagtgtgg atttttttgt 7440 aaaaaagtca tccaaagatc agtagctaag gaggtttgta agcggtttct ataggtacga 7500 aactgttgac cgaccttcat tttttctggg gttaagcagt agaaagtagt agagtctttt 7560 tcccattggt cccatccaag ttctaatgca agttgtaagg catgtttgac aagattgtca 7620 tccccagaca gtttcatcac cagcataaat gggacaagtt gctttccaaa tgcccccatc 7680 caggtgtagg tttctacatc ataggtaata aaaaggcgct cagtgcgagg atgcgaaccg 7740 attgggaaaa agtggatctc ctgccaccag ttggaagaat ggctgttgat gtgatgaaag 7800 tagaaatctc gtcggcggac agagcattca tgctgatgtt tgtaaaagcg tgcgcagtgt 7860 tcgcatcgtt gcacgggctg tatctgttga atgaggtgta cctggcggcc tcgcaccaga 7920 aagcagatgg gaaaatcaat accacttggc agctgccgtt cgtcctcttc ctcttctgct 7980 gcattgccac taccgtttgg atcctcgaaa gcgagaacgg agagggtgac ggtgcccctc 8040 gacctgcatg tccagatttc agcacgagag gggcggaaac gggaaatcag ggcgtacagc 8100 ctggagctgt ccatggtatc agtcagagag aaaagcatgt ccgcggggac agcgcgcaag 8160 ttgacttcgc acaggcgggt aagagcaggc tggaggtgca ggtaatactt aatttctaga 8220 ggcgtgccgt tggcagagtc tattgcgtga agtattccat gagcccgggg actaaccacg 8280 gttccacggt gcacttttcc aatgcgcctg cttaaaatcg gcggcgcgga cgagctcccg 8340 gaggaagcgg cggttcgggt cctgcgggaa gcgggggaag cggtatgtcg gcctgacgct 8400 ctggcagggg aaggtgttga gcccgaagtt gactggcatg ggcgactacc cggcgattga 8460 tatcttgaat ctgtcggcgt tgtgtaaaca ctaccggccc tgttgttttg aacctgaaag 8520 aaagttcaac agaatcaatc tcagtgtcat ttactgcagc ctgtcttaaa atctcctgaa 8580 cgtcgcctga gttatcttgg taggcaattt ctgccattaa ttgatcaatt tcttcctcct 8640 ggaggtctcc atgtcccgca cgttcaatag tggctgcaag gtcattagat atccgactca 8700 taagctgtga aaatgcgttt agtccaattt cgttccagac tcggctgtat actacccctc 8760 cttcgctgtc ccgagcgcgc ataaccactt gcgccaagtt gagttccacg agccgtgcga 8820 acacgccgta gttgcgcaag cgctgaaaca ggtagtttaa ggtggtggca acgtgttctg 8880 agacgaagaa atacagaatc caccgacgaa gcgtcagctc gttgatgtca cctaaggctt 8940 caagacgttc catggcttcg taaaagtcta ctgcaaaatt gaaaaactgg gagttgcgag 9000 ctgccaccgt caattcttct tccaacagac gaataagctc ggccaccgtc tcgcgcactt 9060 cttgctgaaa tgcgcccgga actatttctt gttcttcctc ttctacctcc attatttctt 9120 cctcgaccac aggtggtggg ggttgtcttc ttcgacgccg gcgaacgggc agcctgtcta 9180 caaatctttc aatcatttcg ccgcgacggc ggcgcatagt ttcggttact gctcgaccgt 9240 tttcacgtgg tcgtaactca aaaactccac ctctaagttc tgtttcatgt aaaatgggaa 9300 atgaggcgtt gcgaggggcg ttaggtaggg atacagcgct gattatgcat tttattattt 9360 gctgcgtagg aactccgcgc aaggagctaa gcgtctgcat atccaccggg tcggagaacc 9420 tttcaagaaa ggcatctagc cagtcacagt cacaaggtag gctaagtttt gtttcttcta 9480 aagtaccagg aagctgagca atgctactaa taatgtaatt gaagtaagct gttttaagcc 9540 cacgaatggt tttaagaagc accacatctt tgggtccggc ttgttgaatt cgcaggcggt 9600 ctgccattcc ccacacgtca ctttgacatc gtccaagatc tttgtagtag tcttgcatta 9660 acctttccac ctctacctcg cggtttccgc gatcagccat gtgcgtgctt ccgtagcctt 9720 gcagcggttg taataaagct aaatctgcca ctacccgttc cgcaagcact gcctgttgaa 9780 tttgggtaag ggtggttgca aagtcatcca catctacaaa gcggtgataa gctcctgcat 9840 taatggtgta gctgcagttt gtcattactg accaattaac agtttgcgtg cctggctgta 9900 cagtttctgt gtatcgcaag cgtgagtaag cccgagagtc aaaaacatag tcattgcagg 9960 tgcgcactag gtattgatag cccacaagga aatgaggagg aggttcgcga tacaacggcc 10020 agccaagcgt agccgcagca cctggagcga gatcttccaa catgaggcgg tggtattcat 10080 atatgtatct ggacatccat gtgatgccgg cagcggtagt tgttgctcgc ataaattcgc 10140 gggctcggtt ccaaatattg cgcaggggta aaaagcgttc aatagttgcc acgctttgac 10200 cggtcaggcg tgcgcagtct tgaatgctct ggacatggaa aaaatgaaag ttggtaagcg 10260 actcccttcc gtggtttggt ggaaaagtca caagggtacc atagcgagga accccggttc 10320 gaaaccggca ggatccgcta tgagcacaag tgaggcgctt gcgcgttgaa cccggccaag 10380 gacccccaga cacggagagg agtctttttt tatttatttt ttcttagatg catcctgtcc 10440 tgcgacaaat gcgacctcag cccagggcaa ccacggcctc agcagcggtg gcgctttcgg 10500 gctctggcga acaggaagag cctcaatgtc ctacattgga gttggaagaa ggagaaggca 10560 tagcccgatt gggcgcccac tctcctgagc gtcacccaag ggtgcagctc gcccgggaca 10620 gtcgcgtggc atttgtgcct cgtcagaaca tgtttcgcga caacagcggg gaggaagctg 10680 aggaaatgcg agactgcagg tttagggccg gtcgcgagct gcgccgcgga tttaatcgcg 10740 agcgactgct gcgtgaggag gactttgagc cagatgaaca ttcggggatt agttctgcac 10800 gggcccatgt atcagcagcc aacttagtaa cagcatatga acaaacggtt acagaggaac 10860 gtaactttca aaaaagcttt aataaccatg tgcgcacact aatagcgcga gaagaagtag 10920 ccattggttt aatgcatctt tgggactttg tagaagctta tgtacataat ccagcaagta 10980 aacccctaac tgcccagctg ttcttaatag ttcaacatag tagagacaat gaaactttta 11040 gggatgcaat gcttaacata gctgaacccc agggtcggtg gttactcgat ttaattaaca 11100 ttctgcagag cattgtggtt caggaacgca gtcttagttt ggcagacaag gtggccgcca 11160 ttaattactc catgttaagt ttgggaaagt tttatgctcg taaaatctac aaaagtccgt 11220 atgttcccat tgacaaggaa gtgaagatag acagctttta tatgcgcatg gctttaaagg 11280 tactaacatt aagcgacgat cttggagtgt accgcaatga ccgaatccac aaagcagtaa 11340 gcgccagtcg ccgcagagag ctaagcgaca aagagcttat gcatagctta caaagggcgc 11400 tgacgggagc aggaacagag gacgagtcgt tctttgatat gggcgcagac ctacggtggc 11460 agccaagcgc tcgcgctttg gaggcagctg gagtggcgtc tgctgacgtc actggcgatg 11520 acgatgacga agaccagtac gaggactgat cggccgtacc ttttgttaga tgcagcgacc 11580 ggcgatcatc gcggagaggg ctcctaacct ggatcccgcg gttttggcgg ccatgcaaag 11640 ccagccttct ggcgttacag cttcagatga ctggacagcg gccatggatc gtattatggc 11700 tttaacggcg cgcagtcctg atgcttttcg ccagcagccc caagctaacc gcttttcggc 11760 cattttggaa gcagtagtgc cgtctcgtac taaccctact cacgagaaag tgttaaccat 11820 tgtaaatgct ttgttggata gcaaagccat ccgcaaagat gaggctggtt taatatacaa 11880 cgctttgctt gagcgcgtgg cacgctataa cagtaccaat gtgcaggcta acttagaccg 11940 gatgggtaca gatgtaaagg aggcgctggc tcaacgagag cgctttcatc gcgatggtaa 12000 tcttggttcg ctagtagcat taaacgcttt tttgagtact cagccggcta atgttccgcg 12060 tggtcaggaa gattatacaa acttcatcag cgccttgcga ctaatggtta ctgaagtgcc 12120 tcaaagtgaa gtgtatcagt ctggacccga ttactttttt caaacgtcca ggcagggttt 12180 gcaaaccgta aacttaactc aggcttttaa aaatttgcaa ggtttgtggg gggttcgtgc 12240 tccagtaggc gatcgttcaa ctttgtccag tttactaaca ccaaactcgc gcctattact 12300 gttgctaatt gcccccttta ccaacaccaa cagtttaagt cgagattcat acctgggtca 12360 cttagttact ttgtaccgcg aagccattgg tcaagcgcag gtagacgaac aaacttatca 12420 agaaataacc agtgttagtc gcgcactggg ccaggaggac actggcagtt tagaggccac 12480 acttaacttt ttactaacta accgtcgcca gcaagtgcct cctcagtaca ctttaaatgc 12540 ggaagaagaa cgcatattgc gctatgtaca gcaatctgta agtttgtatc ttatgcgtga 12600 gggtgccacc cccagtgccg ccttagacat gacagcgcgc aatatggagc cgtccttcta 12660 cgcttccaat cgagctttca ttaatcgctt gatggattac cttcaccgcg ctgcggccat 12720 gaacggggaa tactttacaa atgcaattct aaatccgcat tggttgcccc ctcctggatt 12780 ttacactggt gaatttgatt tgccggaagg aaatgatggc tttttgtggg atgatgttac 12840 ggacagtctg tttagtcctg cagttattgg acaccatggt aaaaaggaag caggtgatga 12900 aggtcccttg cttgactctc gggcgagttc tccattcccc agtttaacta gtttacccgc 12960 cagtgttaac agcggtcgta ccaccagacc ccgactaaca ggtgaaagtg aatacttaaa 13020 tgaccccatc ttgtttccag tgcgcgacaa aaattttccc aacaatggca tagaaagttt 13080 ggtagataaa atgtctcgct ggaaaacata tgcacaagag cggcgagaat gggaggaaag 13140 acagccaaga ccagttcgcc ctcctaggca acgttggcag cgacgcaaaa aaggggcaca 13200 tgcgggggat gaaggaagcg atgactcagc tgacgacagt agtgtattag atttaggagg 13260 gtcaggaaac ccatttgctc atttgcgccc acagggttgc atagggtcat tgtattaaat 13320 tgaataaaag catacttacc aaagccatgg cgaccagtgt tcgtcttatt ttccttcttc 13380 cgttagctgt gaaatgaggc gcgcggtgga actgcagaca gtggcttttc ctgagacacc 13440 acctccctct tacgaaaccg tgatggcagc ggcgccaccc tacgtgcctc cccgctattt 13500 gggtcctacg gagggaagaa acagtatccg ttactcggaa ttgtcaccgt tgtacgatac 13560 cactcgagtg tacttggtgg acaacaagtc ttctgacatt gcttcattga attaccagaa 13620 tgatcacagc aactttttaa ccactgtagt gcaaaataat gactattccc ctatagaggc 13680 tggcacgcaa actattaact ttgatgaaag gtctagatgg ggtggagatt taaaaaccat 13740 cttacatacc aacatgccaa acgtgaacga ttttatgttt accaccaaat ttaaggccag 13800 ggtaatggtg gctaggaaaa caaacaacga aggccaaacc attttagaat atgagtgggc 13860 agaatttgtg ctacccgagg gtaactattc ggaaaccatg actattgact taatgaacaa 13920 tgctattatt gagcattatt tgcgagtagg aagacagcat ggagtgctgg aaagtgacat 13980 tggagttaag tttgacacca gaaactttcg tctgggttgg gaccccgaaa cccaattagt 14040 aactccggga gtgtacacta atgaggcttt tcatccagat atagtactgc ttccaggttg 14100 cggggttgat tttacagaga gcagattaag caacatacta ggtataagaa agaggcagcc 14160 gtttcaggaa ggatttgtga ttatgtatga acacttagag ggaggcaata ttccagctct 14220 tttggatgta aaaaaatacg aaaacagtct gcaggatcaa aacactgtaa gaggagacaa 14280 ctttattgcc ttaaataagg ctgctaggat tgaaccggtt gaaacagacc ccaaaggacg 14340 cagttacaac ttgcttccag acaaaaaaaa tactaaatat cgcagctggt atttggcata 14400 caactacgga gacccagaaa aaggagttcg gtcatggact ctactaacaa ctccagatgt 14460 aacaggcggc tccgaacagg tgtactggtc cctacccgat atgatgcaag atccggtgac 14520 ttttcgctcc tcgcgtcaag ttagcaacta tcctgtagtt gcagcagaat tactgccagt 14580 tcatgctaaa agcttctaca acgagcaagc cgtctactca cagcttattc gccagtcaac 14640 cgcgcttacg cgcgtgttta atcgctttcc cgagaaccag atactggtgc gtccaccagc 14700 cgctaccatc actaccgtca gtgaaaacgt tcccgccctt acagatcacg ggaccctgcc 14760 gctgcgtagc agtatcagtg gagttcagcg agtcaccatc actgacgccc gccgccggac 14820 ctgtccctac gtttacaaag cactgggcat agtttctcca cgagtgcttt ctagtcgcac 14880 tttttaaaaa agtgtggtaa catgtccatt ttggtttcgc caagtaacaa cacgggctgg 14940 ggactgggtg ccgcccgcat gtatggagga gctaaaacaa ggtctagcca acatccagtg 15000 cgcgtacgcg gacattaccg agctccatgg ggcgcgcata cccgaggacg cactggtcgc 15060 accactgtag acgatgttat tgactcggta gtggccgatg ctcgcaagta ccgcgcgccc 15120 gctgaaacag cagggtctac tgttgatgca gtaattgatg aggtagtggc aaacgcgcgg 15180 gcttatgcaa ggcgccgcag acggctgcgt cgccggcgta gaccaaccac cgccatgcgc 15240 gcggccagag cgttggttcg acgggccagg cgcattgggc ggcgagctat gatgcgggca 15300 gccaggcggg ctgcaacgcc tgccggtcga gcgcggagac gggccgcagc tgcggccgca 15360 acagctattg caaacctagc tgctccgcga cgaggaaatg tatactgggt gcgcgactca 15420 gtgaccggga cgcgtgtgcc agttcgtacg cgtccacctc acccttagaa gacaaagagt 15480 gactcaatgt ctgttatgta tgcccagcat gaccaaacgc aagttcaaag aagagctgct 15540 gcaggcctta gcgcctgaaa tatatggccc atcggataac cttaccaagc gcgatatcaa 15600 gcatgttaaa aaacgggaaa aaaaagagga agaagtcgcc gcggcgtcag cagacggcgt 15660 cgagtttgtg cgctcatttg cgcccagacg tagggtacag tggaagggac ggcaagtaaa 15720 acgcattttg cgaccgggca ccacagtggt tttttctccc ggagagcgaa cgattatgcg 15780 tcccctaaag cgcgagtacg acgaagtgta cgcagacgat gacattttgg agcaagcggc 15840 acaacagact ggggaatttg catatggaaa aaaagggcgt tacggagaca aaattgctat 15900 tcctttggac gagggaaatc caacacccag tttaaaggct gtcactttgc aacaagtgtt 15960 gcccgtcctt gggccttcgg aagaaaagcg tggaattaaa agggaagcca tggatgaatt 16020 gcagcctaca atgcaactga tggtgcctaa gcggcaaaag ttagaggacg tactagagca 16080 catgaaggtg gatcctagcg tacagccaga tgtaaaagta cgtccgataa aaaaggtagc 16140 tccaggattg ggagttcaaa cagtggacat tcaaattcct gtgcaaactg cattgggtga 16200 aactatggaa atccaaactt cgccaataaa aacaacggtg aacgcaagcg tgcaaacaga 16260 cccttggtac ccgccagtgc tttcaacaaa aaaaaagcgt cactacagac aaacaagttc 16320 gcttttgcca gactacgttt tacatccttc cattgtgccc acgcctgggt accgtgggac 16380 aacttttcag cgccgagcca cagcccctag ccgtagacga ggtccatcac gccgtagacg 16440 tcgacgcaaa gccactttag ccccagcggc agtacgtcgc gttgtacaaa gggggcgcac 16500 actaatactt ccatccgtgc gttaccaccc tagcattctc taacaagctg cgctgccgtt 16560 ttttcagatg gctcttactt gccgaatgcg catacccatt ccaggataca gaggacgacc 16620 ccgccggagg aaagggctga ccgggaacgg tcgatttcgg cggcgtagta tgcgcagacg 16680 catgaagggt ggggtgctgc ccttcctaat tccacttatt gctgcggcca ttggagccgt 16740 tcccggaatt gcctcagtag ccttgcaggc ttctcgaaaa aattaaaata aaataaaact 16800 tccaacttat tactggtact atgactgttt tatgcagact aaatggaaga catcaatttt 16860 tcgtcgctgg ccccgcgaca cggcacgcgg ccgtacatgg gcacctggaa cgagatcggc 16920 acgagccagc tgaacggggg cgccttcaat tggaacagta tctggagcgg tcttaaaaat 16980 tttggttcca cgattaagac atatggcacc aaggcgtgga acagccaaac cggccagatg 17040 ctaagggaca agttaaaaga ccaaaatttt caacagaaag ttgtagatgg tctggcttcg 17100 ggaattaatg gagttgtaga catagccaat caggctgtac agaaaaaaat tgccaaccgt 17160 ttagagccgc ggcccgacga ggtaatggta gaggaaaagc tgccacctct agaaactgtg 17220 cccggatccg ttccaaccaa aggagaaaag cggccacggc cggatgcaga ggaaacctta 17280 gtaacgcaca caacagaacc gccgtcctat gaggaagcaa taaaacaagg agccgctctg 17340 tcacctacca cctatcccat gaccaagcct attttaccca tggctactag agtgtatgga 17400 aaaaacgaaa atgtgcctat gacccttgag ctgcctcctt tgccagaacc cactatcgcg 17460 gatcccgtag gttccgttcc tgttgcatct gttccagttg catcgacagt gagccgtcca 17520 gcagtgcggc ctgttgccgt ggctagcttg cgaaacccac gatccagtaa ttggcaaagt 17580 accctaaaca gtattgtggg actgggagta aagtctctca aacgccgacg ctgctactaa 17640 cattaaaaga cgagtgttaa ttcccatctg tgtatacgcc tcctatgtta gcgccagagg 17700 accaacgcgt gaatcgcagt caccaccagc gctttcaaga tggccactcc ctcgatgatg 17760 ccgcagtggt cttacatgca catcgccggt caggatgcct cggagtacct gagtcccggt 17820 ctggtgcaat tcgcccgcgc cacggacacc tacttcaccc tgggaaacaa gtttagaaac 17880 cccaccgtgg ctcccaccca tgatgttacc accgatcgct cgcagcgtct gacgctgcgt 17940 tttgtgcccg tggatcggga agatactacc tactcctaca aggctcgctt tacgctggct 18000 gtgggtgaca accgcgtgtt agacatggct agttcttact ttgacattcg aggggtactg 18060 gatcgtggtc ccagttttaa gccctattcc ggaaccgcct acaattcttt ggcaccaaaa 18120 ggcgctccta atgcttcaca atggtcagat aacgctaagc ttaatacctt tgctcaggcg 18180 ccgtatctta gcgacactat caccgccgcc gatggtatta aagttggaac agacaccgcc 18240 caggcaggcg cggcggtgta tgccaacaaa acttatcagc cagagccgca agtaggacca 18300 agtgaatgga acaccagcat tgaaaacgtt aaagctggcg ggagggcatt aaagcaaacc 18360 actgcaatgc agccgtgcta tggctcctac gctcgtccaa ccaacgaaca cggaggacaa 18420 tccaaggatg acaacattga acttaagttc tttgattcag ctaacaatgc agcaaacact 18480 gctcaagttg tgttctatac cgaagacgta aaccttgaaa tgccagacac gcatcttgtg 18540 tttaagccta ctgttaccaa tggaacaatt gcttctgagt cgctgttggg acagcaagca 18600 gcgccaaata gagcaaacta cattgcattc agagataatt ttattggcct gatgtattac 18660 aacagtacag gcaacatggg tgtattggcc gggcaagctt cccaacttaa cgcagtagta 18720 gacctgcaag acagaaatac agagctgtca taccagttaa tgctggatgc tttgggagac 18780 agaacacggt acttttcctt gtggaattcc gcagtggaca gttacgaccc tgacgttcgc 18840 gttattgaga atcacggggt agaggatgaa ctaccaaatt attgctttcc tcttagcgca 18900 gtaggtgaaa taaaaaatta caaaggcatt aagccagata acggaggagg aggtggctgg 18960 actgccgaca acactgtcag tgaagcaaac cacataggca ttgggaatat agccgccatg 19020 gaaattaatt tgcaggctaa tttgtggaga agcttcttgt actcaaatgt gggcttatac 19080 ctaccagacg acttaaaata cactccagga aacataaaac tacctgataa caagaacacc 19140 tacgagtaca tgaacgggcg tgtgactgcc ccggggttgg tggataccta tgtcaatatc 19200 ggcgctcgct ggtccccaga tgtgatggat aatgtaaacc cttttaacca ccaccgaaac 19260 gcagggttgc gctacagatc catgttgcta ggcaatggga gatttgttcc ttttcacatt 19320 caggtgccgc aaaaattttt tgccatcaga aatttgttgc tgttgcccgg ttcctacact 19380 tacgaatgga actttagaaa ggatgtaaac atgattcttc agagcacact gggaaatgat 19440 cttcgggtgg acggagccag cgttcgcttt gacaacattg ccctgtatgc taactttttt 19500 cccatggcac ataacacagc ttctacttta gaagccatgt taagaaatga caccaacgac 19560 cagtctttta acgattattt gtgtgctgca aacatgctgt atcccatccc agctaacgcc 19620 accagcgtgc ccatttcaat accttcgcga aattgggcgg catttagagg ctggagcttt 19680 actcgcctaa aaactaaaga aactccttcc ctgggttcag ggtttgaccc ctactttgta 19740 tactctggaa ccattcccta tttagacggc accttttacc taaaccacac ttttaagaag 19800 gtgtcaatca tgtttgactc ctccgtgagt tggcctggaa atgaccgttt gctaacccca 19860 aatgaatttg aaataaagcg ttctgtggat ggggagggat acaatgtggc ccaatgcaat 19920 atgactaagg attggttcct aatacaaatg cttagtcatt acaacattgg ataccaaggt 19980 ttttacattc cagagagcta caaggaccgc atgtattctt tctttagaaa ctttcagccc 20040 atgagtaggc aagttgtgga taccacagaa tataagaact acaaaaaagt aaccgtagag 20100 tttcaacata acaactcagg attcgtggga tacctgggcc ccactatgcg ggagggacaa 20160 gcttaccccg ccaactatcc ctaccctctt ataggccaaa cagctgtgga aagcatcaca 20220 cagaaaaagt ttctatgcga tcgtgttatg tggcgcatcc cattttctag taacttcatg 20280 tctatggggg cgctaacgga tcttgggcaa aatatgctgt acgcaaactc agcccatgct 20340 ctagacatga catttgaggt ggatccaatg gatgagccta cccttcttta tgttttattt 20400 gaagttttcg acgtggtacg cattcaccag ccacaccgcg gcgtcattga agcggtctac 20460 ctgcgcacgc ccttctcggc gggtaacgct accacctaag aaggcaccct cccagactgc 20520 tgtaatgggt tcaagcgaac aggagctgac ggccattgtt cgagatctag gctgtggacc 20580 ctattttttg ggaacctttg acaaacgttt tccgggtttt gtgtctcgcg accgcttatc 20640 atgtgctatt gttaacactg ccggtcgcga aactgggggc gtacactggc tggcttttgg 20700 atggaacccc aaatcgcaca cttgctattt attcgatcca tttggatttt ctgatcaacg 20760 actaaaacaa atctatcagt ttgagtacga aagtctgttg cgccgtagtg cgctagcggc 20820 cactaaagac cgatgcgtta ccctagaaaa gtcaacccaa actgtacaag gaccgttttc 20880 tgcagcgtgc ggcctgtttt gttgtatgtt cttacacgct tttactcact ggcctgacca 20940 tccaatggat aaaaatccca ctatggacct acttactggg gtgcctaatt gtatgctaca 21000 aagtcctcag gtagtgggca cattgcaacg caatcagaat gaattgtata aattcttaaa 21060 caatctgtcc ccttactttc gtcacaaccg cgagcgcata gaaaaagcta catcttttac 21120 taaaatgcaa aatggactca aataaacgtg tacacaatgc attaataata aaaccatttt 21180 attagctcat tggagtacaa gcttgactgt tttattaaaa atcaaatggc tcttcgcgac 21240 agtcgccgtg gttggtgggc agggatatgt ttctgtactg caaacgctga tgccacttga 21300 attctggaat aacaagccta gggggggagc cgtcaaaatt ttctccccac agctggcgca 21360 caagttgcag ggcgcccata acatcaggag cagaaatctt gaagtcgcaa ttagggccag 21420 cattgccgcg cgcattgcga taaactggat ttgcgcactg aaaaaccaac aaacacggat 21480 acttaatact ggctaacgct ccagggtcgg ttacttcgtt gatatcaatg ttatccacat 21540 tgctgaggtt aaaaggagtg attttacaca gttgacgccc catccgtggc aggccatctt 21600 gcttgtttaa acattcgcag cgcactggca taaggagacg tttttgccca tgtcgcatgt 21660 gagggtagtc ggccagcata aaagcttcaa tttgcctaaa agctatttga gccttcattc 21720 cttcagaata aaacaagccg caggactttc cggagaaaga attattcccg cagccaacat 21780 catgaaaaca gcagcgggca tcgtcgtttt taatttgaac tacattacgc ccccagcggt 21840 tttgcgccac cttggctttc gaggggttct ctttcaacgc tcgttgccca ctttcgctgg 21900 ttacatccat ttccaccaaa tgctctttgc gcaccatctc cattccatgc aggcatctaa 21960 gctccccttc gcgctcggta cacttatgct cccacacgca gcaaccggtg ggttcccagg 22020 aattctgttg gacaccggca taagcttgca tatatccttg caaaaagcgt cccatgagct 22080 cctgaaaggt tttttgggat gaaaaagtca gctgcaaacc gcgcttttct tcgttgagcc 22140 atgttgtgca tattttcttg tacacgctgc cctgatccgg caaaaaacga aaggtggcgc 22200 gctcgtcgtg atccacatgg tacttttcca ttagcatagc catggcttcc atgccttttt 22260 cccaagctga aactaggggc tggcttgccg gattgcgaac aacaacaaca ttcttttcat 22320 tttcgtcgct gttttgagcg gaagccttca aaacgtgtac ctgcctggtt tccatttttt 22380 gaaaagactg agaaccgtct gcatgatgca taatgcggac gggcggcatg ctgaaaccca 22440 ttactcctaa aactgctctt ggtggttctg cctcttcttc ttctgcactc tctggggaaa 22500 gaggtatcgc agccatagat ttcttgactt ttttctttgg aggtaaaggc acagcttcca 22560 gttcttcttc gctttcggaa tccagaaagt atctgcccat ttttggcggc ggcggctgag 22620 cgctgcggtc tggggtgcgc tccctctgtg agtgctgatt gctggccatt atttaatcct 22680 aggcaaagaa acacatgatg gatctggagc cacaggaaag cttaaccgcc cccaccgctc 22740 ccgccattgg cgctacggct gtcatggaga aggacaaaag tctactcata ccccaagacg 22800 caccggttga gcagaacttg ggctacgaga ctccccccga ggaatttgaa ggctttcttc 22860 aaatccaaaa gcaaccaaat gagcaaaacg ctgggctcga ggaccatgac tacctaaacg 22920 agggagatgt cctgtttaaa catctacagc gacaaagcac tatcgttcgc gacgccatat 22980 ctgatcgctc ttcaatacca gtttcaattg cagaactatc ttgcatctac gaacgcaacc 23040 tgttctcccc acgtgtgccc cctaaacggc aagccaacgg cacatgcgag ccaaatcctc 23100 gccttaactt ctacccagtt tttgcagtgc cagaagcact ggcaacatac catattttct 23160 ttaaaaatca caaaataccc ctatcctgtc gagctaaccg cagccgcgca gatgagcttc 23220 ttgctttaag ggctggcgct tccatacctg ggattgtgtc cttggaagag gtgcctaaaa 23280 tttttgaagg tttaggtcgg gatgaaaaac gagcagcaaa tgccctgcaa aaagaaaatg 23340 aacaaaatca ccatgggaat agtgctctaa tagaactgga aggtgacaat gcccgcctgg 23400 cagttttaaa gcgcaatatt gaggttactc actttgccta cccggcagta aatcttccgc 23460 caaaggtaat gagcgcagtg atgaatcagc tactaattaa gcgagcccaa cccattgaca 23520 aagatgcaaa cttgcaagac ccggaggcaa cagatgatgg aaagccggtt gtaagcgacg 23580 agcaattaac taagtggttg ggaacagaca attccaacga actacaacag cggcgtaaac 23640 tcatgatggc cgccgtactt gtaactgtgg aactcgagtg catgcatcgt tttttctccg 23700 acatcaccac attgcgcaaa attgaggaat gtcttcacta cactttccgc catggctacg 23760 tgcgccaagc ctgtaaaatt tctaatgtgg agctgagcaa tctagtttct tacatgggca 23820 tcttgcatga aaaccgattg ggacagaacg tgctacactc aacactacgc gatgaagcac 23880 gcagagatta cgtgcgagac tgcatttacc ttttcctgtt acatacctgg caaactggga 23940 tgggtgtttg gcagcaatgc ttggaagaaa aaaaccttcg agaactaaac aaactgttag 24000 acagagcact aaaatcccta tggaccggtt ttgacgaacg gacagtagct gcagagctag 24060 ctgacataat tttcccagaa aggttaatga taaccttgca aaacggcttg cctgacttta 24120 tgagtcaaag tatgctgcac aattatcgct cttttatatt agagcgttct gggatgcttc 24180 ctagcatgtg ttgtgcactt ccttcagatt ttgtgcctat atattttaga gagtgccccc 24240 ctcccctgtg gagccactgc tacttactac gacttgctaa ctacctagct taccactcag 24300 accttatgac agattcaagc ggcgaaggcc taatggagtg tcactgccgc tgcaatcttt 24360 gcacccccca ccgttctttg gtttgcaata ctgaactatt aagtgaaagt caagtcattg 24420 gtaccttcga aatgcaggga ccgcagtctg acagcaattt cacgacgaac ctaagactta 24480 cccctgggct ttggacttct gcctacctgc gcaaatttga accccaagat taccacgccc 24540 acagtatcaa tttttacgaa gaccaatcca aacccccaaa agcgccacta acggcttgcg 24600 tcattacgca gggaaaaatt ctagcccaat tgcatgctat taagcaagcg cgcgaagagt 24660 ttttacttaa aaaaggacac ggagtgtacc ttgatcccca aaccggcgag gaactaaacc 24720 ttccatcacc tttgtgtgct actgcgtctc cccattcgca gcatgtcccc gaaagccgca 24780 aaacaggcta ttgcgcagca acgctcaaag aaacagcagc aacggcagga aatctgggag 24840 gaagaatctt gggagagtca ggcagaggac gaggtcgagg acttggaaga atgggaggag 24900 gaggaggcgg acagcctaga cgaggatcca gaggaggagg aggaaggttc caaggacgga 24960 gcgaccgccg ccaaaccgtc gctttcaacc aagccctctc caatgaaacc cgctgtgagc 25020 aaatctcaga aagccaaccg tagatgggac accattgaaa ccagcgccgc aaacttgggt 25080 aagaatcgca agcaggcgcg tcggggctac tgctcatggc gggctcacca aagtaatatt 25140 gtagcctgct ttcagcactg cggggggaat atctcatttg caaggcggta tttgctatac 25200 catgatggag tggcgattcc aaggaatgtc ctccattact accgtcatct ctacagcccc 25260 tttgaagagc tcgacaagga accgacctgc aacagccaag cggcccacta gaatcggcaa 25320 cagcagcaac aaggaaagtc ctgaggcgcg cgagttaaga aaacgcattt ttcccacttt 25380 atatgctatt tttcagcaga gtcgaggtca agaacacgaa ctgaaaataa aaaaccgttc 25440 cctgcgttca cttacccgca gctgtctcta cctcaaaagc gaagatcagt tgcaacgcac 25500 cttgcaggac gcagaagctc tgttcaataa atactgctcc ctctcgctta aagagtaaaa 25560 aaagcccgcg cgcggacttt caacaggcgg gaaaagtgac gtcacaacaa gatgagtaaa 25620 gatattccca cgccttacat gtggagcttt caaccccaaa tgggactggc ggccggcgcg 25680 gctcaagact attctagcaa aatgaattgg ttaagcgccg gaccccacat gatttccagg 25740 gtgaatgggg tacgagcccg gcgtaaccaa atactgctag aacaagccgc tctcaccgct 25800 acaccacgta atcaacttaa ccctccctct tggccagctg ccctgatata tcaggaaaat 25860 ccccctccta ccactgtact tttgcctcgc gacgcccagg ccgaagtcca tatgactaac 25920 gctggggcac agcttgcggg cggtgcacgt cacagtttca ggtataaagg tcgcactgag 25980 ccctatccgt ctccagctat aaaaagagta ctcatcagag ggaaaggtat tcagctgaac 26040 gacgaagtca catcgccatt gggagtcaga cccgacggag tgtttcagct cggagggtcc 26100 ggacgttcct cctttaccgc tcgtcaagcc tacctgacac tacagagctc atcctcagct 26160 ccgagatctg gtggtattgg aactctccaa tttgtggagg aatttactcc atctgtttac 26220 ttcaatcctt tttcgggctc gcctggacac tatcctgacg ccttcatacc caactttgac 26280 gcagtgagtg aatctgtgga tggctatgat taatgtctaa tggagcggct gacagagcgc 26340 ggctgcgaca tttagaccac tgtcgccaac ctcactgctt tgctcgagac atctgtgtct 26400 ttacctactt tgagcttcca gaggagcacc cccaggggcc agctcacggt gtcagaataa 26460 cagttgaaaa aggaattgat acacacctca ttaaattttt caccaaacgc ccgctattgg 26520 tggaaaaaga tcaaggaaat actatattaa ctttatattg catttgtcct gttcccggat 26580 tacatgaaga tttctgctgt catttgtgtg ctgaatttaa tcatctgtag tggcgctgta 26640 ccgcctgaag aagaacctaa ctgtcatccg catttaagca acattaaaat caacctttcg 26700 atccctcata tcactcttcg ctgcagtttt ttttccacac atctcacctg gacctttaac 26760 ggaaaacacg ttaccaatac agatataaag tttaaactac acaaagaaaa catcactcta 26820 tttcaaccta ttaacctggg atactaccgc tgctcagctc caccctgtac gcaagcattt 26880 tttgttgctc cagttattga caaacgccct gctccgacaa cagctgctgt cactgagcac 26940 atcaccgagg cagtttctcc ttctaaaggt acagaggaaa ttgtgtactt ttcaaacttt 27000 acaaaccact tagttttaaa ttgttcctgt tctaactcct taatttcatg gtttgctaac 27060 agctctctgt gcaaaacttt ctaccaagga aaacttttgt attctgctaa actcacattg 27120 tgtaaccaga gcaccccttc ccaccttact ctattgccac cttttgttgc cggtcgttac 27180 ttttgcatag gagctgcacg tactagcccc tgtcaacagc attggaattt aacttactgt 27240 cccccaccag tgtcgccctt tgtgatcaat actgaatatt tagactataa tcccttgctt 27300 gcttacggcg gtctcgcagc tcttatttta ttcctgattt ctaacttgtt tctagtgcaa 27360 catttgtatt catactaaca atgctttcca tttttctttt atttctcttt tctttacctt 27420 ctggcttgta tgctcaaaca gccgaaagac cactaaaagt cgtggtggaa gctggccata 27480 atgtaaccct tccccacctt tctggttcac accaaactgg ccatgttact tggctagtag 27540 agacatcaga ttatggttca gcttctccag acaacttcat tttcagtgga caaaaactat 27600 gccagtttac tgacagaacc atggtgtggc cttattacaa tttacatttt aactgtgaaa 27660 attatgacct taatctgttt tggcttaagg tggaaaattc ggctatttac aacgttaaaa 27720 atacagtcaa tgcttctgaa acaaatattt actatgattt aagagtagta caaatttttc 27780 cacctaaatg catcattact tcaaagtacc ttacaaacga ttattgtcac attacaatta 27840 actgcactaa ctctgattac cccaataagg ttgtgtttaa taatgtcagt cgatggtact 27900 acggatacgg taagggcagc ccaacccttc ccaactactt tataactaac tttaatgttt 27960 caggtattac taaaagcttt aatcacactt acccttttaa tgagctctgt gattatccca 28020 catcccaatc tcaacacagt ttaacacata cagtaagcac agtaatcttt ttaggaataa 28080 ttggcttcag cattttgatt attatagcag cctttattta tctgtgctgg catagaaaat 28140 ctttgtgtgt ttctaaaaca gaacctctta tgccgattcc ttactagttt tcttttttct 28200 tacagtatgg tgacggttct tctcatcttt ttatgcctgc cagtcatttt ttcttcttcg 28260 acttttgccg cagtcagtga ccttgatccc gagtgtttag ccccctttgc ggtgtacctg 28320 attttcacat ttgtgactgc tacctgcgtc tgcagtatta ttactctgct aatcacctcg 28380 ctccaatttt ttgattacta ctacgtgaga attgtttacc gcagacacca cccccgttac 28440 caaaaccctc aaattgcggc tcttttgcag ctccaaccat gaaaacagca ttagttcttt 28500 tctttatgtt aatcccagtt tgggctagtt cttgtcaact acataaacca tggaattttt 28560 tagattgtta tactaaagaa acaaactaca taggctgggt ttatggaatt atgtctggct 28620 tagtatttgt ctcctctgta gtttctttac aactgtatgc gcgccttaat tttagttgga 28680 ataagtatac tgatgatctt cccgaatatc caaaccccca ggatgattta cccctaaata 28740 ttgtatttcc agagcccccg cgtcctcctt ctgttgttag ctattttaag ttcaccggtg 28800 aagatgattg aacctgatct agaaattgat ggaagaatca ccgaacagag gctcctcact 28860 gatcgcgcta ggcgacgcca acaggatcaa aaaaataaag agttaattga tttacaaacc 28920 gtgcatcagt gtaaaaaagg acttttttgc ctggtaaaac aagctaccct tcgctatgaa 28980 tctttaccag gcaaagaaca tcaactgtgc tacacgctgc ccactcagcg acaaaccttt 29040 actgcaatgg tgggctcggt acctattaaa gtgtcccaac aagcaggaga acaagaaggc 29100 tctattcggt gcctatgtga taaccctgaa tgtttgtaca ctttaataaa aacactgtgc 29160 ggtttaagaa atcttttacc aatgaattaa ataaattact taccggaaat ctgaaaatac 29220 atcatggtct ccgtgtactc ttataaaatt tccctcttcc caactgtcaa acctgacaga 29280 cttgcaaaca gcaaactttc tccaaatctt aaatggaagg tcagattctt cttcccaatc 29340 cctacccacc atcttcatct tttctagatg aagcgcagca gaacccagta tgctgaagaa 29400 acagaagaaa atgatgactt caaccccgtt tacccttttg acccatttga cacatcagac 29460 gtaccctttg ttacaccccc ttttacttct tccaatggtc ttcaagaaaa accaccaggt 29520 gtattagcac ttaattacaa agaccccatt gtaactgaaa atggaaccct tacactcaag 29580 ctaggggacg gaataaaact taatgcccaa ggtcaactta cagctagtaa taatatcaat 29640 gttttggagc cccttaccaa cacctcacaa ggtcttaaac tttcttggag cgccccccta 29700 gcagtaaagg ctagtgccct cacacttaac acaagagcgc ccttaaccac aacggatgaa 29760 agcttagcct taataaccgc ccctcccatt acagtagagt cttcgcgttt gggcttggcc 29820 accatagccc ctctaagctt agatggaggt ggaaacctag gtttaaatct ttctgctccc 29880 ctggacgtta gtaacaacaa tttgcatctc accactgaaa ctcccttagt tgtaaattct 29940 agcggtgccc tatctgttgc tactgcagac cccataagtg ttcgcaacaa cgctcttacc 30000 ctacctacgg cagatccgtt aatggtgagc tccgatgggt tgggaataag tgtcactagt 30060 cccattacag taataaacgg ttccttagcc ttgtctacaa ctgctcccct caacagcaca 30120 ggatccactt taagtctgtc tgttgccaat cctctgacta tttcacaaga cacattgact 30180 gtttccactg gtaacggtct tcaagtgtcg gggtctcaat tagtaacaag aataggggat 30240 ggtttaacat tcgataatgg ggtcatgaaa gtaaacgttg ccgggggaat gagaacttct 30300 ggcggtagaa taattttaga tgttaattat ccctttgatg cgagcaataa cctgtcctta 30360 agacggggat tgggactaat ttataaccaa tctacaaact ggaacttaac aactgatatt 30420 agtaccgaaa aaggtttaat gtttagtggc aatcaaatag ctcttaatgc aggtcagggg 30480 cttacattta ataatggcca acttagggtt aagttgggag ctggacttat ttttgattca 30540 aacaataaca ttgccttagg cagcagcagc aacactccat acgaccctct gacactgtgg 30600 acaactcctg acccaccacc aaactgcagc ctcatacaag agctagatgc aaaactcacc 30660 ctgtgcttaa caaaaaacgg atctattgtt aatggcattg taagtttagt gggtgttaag 30720 ggtaatctcc taaatatcca aagtactact accactgtag gagtgcattt agtgtttgat 30780 gaacagggaa gattaatcac atcaacccct actgccctgg ttccccaagc ttcgtgggga 30840 tatagacaag gccaatcagt gtctaccaat actgttacca atggtctagg ttttatgcct 30900 aatgtgagtg cttaccctag accaaatgcc agtgaggcta aaagccaaat ggtaagtctc 30960 acgtacttac agggagatac atctaaacct ataacaatga aagttgcatt taatggcatt 31020 acgtcgctaa atggatactc tttaacattc atgtggtcag gtctatcaaa ctatataaat 31080 cagcctttct ctacaccatc ctgctccttt tcttacatta cccaagaata aaaacacaca 31140 caaaacacaa attgcgtact tattgtttat tttttttttt ttttacacta tacgcgtggt 31200 taaactgcct ccttcccatt ttaccttgta tacctccctt tccccctttg tagctgaaaa 31260 caactgcact tgaatatttc gacttaggtt ttttggcgtt agcgtccaca cagtttcttt 31320 acgggcaaag cgagggtcgg tgatggaaac gaatccctcg cccgcacagt cactcaagcg 31380 gcattcccca tccaaaacca ggtccatgat tttatcctac aaaaagtaac aacagtcagt 31440 gtccatcagc cgcccaagga ttctctcgtt gattataatc tccaaataaa attgctcgat 31500 gatgcataat taaacccttt agcagttgct gacgataacg ttcatgccga ctatgtttta 31560 gagggcgaac agtgttttca gcaattactt gaacaacttt taacattagc agtctggtac 31620 gacgagcgca acagcgcatg cgtatctcac ttaagtcttt acaataatca caacacagca 31680 ctaacatgtt atttaaaatt ccataattaa aggcgctcca tccaaaacta actttttcta 31740 acgctaacca ggcatggcca tcatacataa ttttaaagta aattaaatgg cgacctctaa 31800 caaaggtgct tcccacatac atcacctctt taggcattaa atggttaaca acctcccgat 31860 accaaaaaca ccttttgtta attaaggcgc catatacggc cattttgaac cagcgtccca 31920 aaagcatccc agctgacata cactgtagtg aacccggacg ctggcaatga caatgaataa 31980 gccaccgctc atgaccatgt aataattgag taacttcaac atttatagtg gcacaacaca 32040 tacatacact catgtatttt ttcaaaataa acatctcata atcagttaga atcatatccc 32100 acggtattgg ccattcctgc agcactgtaa aacctacaca tgaaggaatg cctcttacct 32160 cacttacatt atgtaaagtc agactattac actcaggcca taaagaattt tccgaagtac 32220 tcaacgtagc ttttgactgt tcctcacagg gcggtagttg gtacttgttg tatggtgcca 32280 atctgtagcg ataccgtctg tcgcgctgca tcgtaaacaa cagacttgcg agcgtcttcg 32340 tacttaaaaa aacaaaacca cgtacgacca ctggttatcg cacctcgtcc tttttgtttg 32400 cagcgttggc gttccgtcaa aaaagcaaag tacaaccact ctcgcaggct tgctaaaatg 32460 tattcagctt caggtgttat cttcaaatca tgatgtttaa taaagcgcag agtatccaca 32520 caggatgcat gggctaaacc aagccatgct atgcaggcag ccgtgtcccg acttacagga 32580 ggaggaggaa tacaaggtag aggcataaaa acttaatcaa gacggtcagc aaggatttga 32640 atgcgtaaat ctcgcaggtg gcagcgatcg cctccgctgt gctggtgaaa gatcacagcc 32700 agatcaaatt gtaagcgatt ttccaaatgt tcaacaacag cttctaaaag agccacagct 32760 ctgatttcga taaacaaaag caaagcaaat gcattatcat gaaactcttc tatcatcaaa 32820 ctgcctgact gaaccattcc caggtaattt tcattcttcc actgttgtat tatttgaaca 32880 cactgatttt gcaggtttaa accgtgaata ttaaaaagct ctgtaagggc gccctccacc 32940 gccatccgca ggcagtactt catatttgct gaaaaaagtc tggatcttca aacacctgca 33000 gtaaattcag tagatttaca ttaggctcca caccttggtc tcgcagctga catcttaatg 33060 ccagttgtat aaaatcatac aaatcagaag ccagcagcaa agaaagttca cctccaggta 33120 caagttccgg agttcccaca gaacatacaa cttgcacaaa tggacccata ttagtaagcg 33180 tggcgccaac gtagacatcg cgcataggag gagttaaata atgcattacc agcagccaaa 33240 actcaggtag cacgtcttta agaaacgtca ccacctcaaa atctaagcca tgcaaatagt 33300 tccgtaaaga ctccggaaac aacacggagt aatgaacaag cgacctctga aacatgcttt 33360 aggttagcct gaaaaataaa aatatgttaa attaaagatg cctggcaaac gggtggaaaa 33420 acaactctac ttaaaagcaa gcgcgcgact ggctgctttg cgcgaacatc gcaaaacacg 33480 tcggaatgat taaacaacaa aacactgagc tccattcttg agcctggata aagcgtttca 33540 gcgccaacaa aaacccctct ggcgttcatg tcgcataatg aaaacaatgt tcccaaatat 33600 ccaggaggaa tatcaactgc tatgtgcaaa tataaaagca caactccatg tggaggtata 33660 acaaaattcg caggagaaaa taacacataa gcattagagt cgccctcttg tttaggcaac 33720 atagccccag gtcccgtaaa atacacataa agagtctcaa aagcagccat aatgccttac 33780 cagaaaaaca gtacaaagcc aggcacagca gacacaatct gccgcaagtg cgcaccttta 33840 atactgaaaa atagtgacgt aaatggccaa agttcgccta cacaacacaa aaaaaacccc 33900 aaaagcccgc gaaaaaaatc acttccgcat atgactcggc ataatacggt gttctcacga 33960 cacgtcacat ccggcgcgcc cggctcccac gccgcgcccc acttcctcat ccgcccaaac 34020 ttacaagcac gccaaagcca cacctccacc caatcaaatt acacactacg cccacttcat 34080 tttaatattg gcactagtcc agtataaggt atattattag atagg 34125 <210> 143 <211> 34775 <212> DNA <213> Human adenovirus type 34 <400> 143 catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60 aaaattgtgg ggtgtgtggt gattggctgt ggggttaacg gctaaacggg gcggcgcggc 120 cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180 acgcataaaa aggctttttt tctcacggaa ctactgactt ttcccacggt atttaacagg 240 aaatgaggta gttttgaccg gatgcaagtg aaaattgctg atttgcgcgc gaaaactgaa 300 tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg 360 ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt 420 ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctacggtatt 480 tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc 540 tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat 600 aatttctgct gagactggaa atgaaatact ggagcttgtg gtgcacgccc tgatgggaga 660 cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt 720 agaggtagag ggatcggagg attctaatga ggaagctgtg aatggctttt ttaccgattc 780 tatgctttta gctgctaatg aaggattaga attagatccg cctttggaca ctttcgatac 840 tccaggggtg attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgggttccgt 900 ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga 960 aaaggagcag tctatgcaga ctgcagcggg tgagggagtg aaggctgcca gtgttggttt 1020 tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa 1080 aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagagcgc actgccactt 1140 tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat 1200 attgagtggg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgagtcacc 1260 atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg 1320 caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga 1380 cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacggc caagacaata 1440 agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaga gtgcaatgta 1500 ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata 1560 taagtagaag cagacctgta tggttagctc ataggagctg gctttcatcc atggaggttt 1620 gggccatttt ggaagacctt agaaagacta ggcaactgtt agaggacgct tcggacggag 1680 tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa 1740 aacaggacta taaagaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag 1800 ctcttaattt gggccatcaa gttcacttta aagaaaaagt tttatcagtt ttagactttt 1860 caaccccagg tagaactgcc gctgctgtgg cttttcttac ttttatatta gataaatgga 1920 tcccgcagac tcatttcagc aggggatacg ttttggattt cgtagccaca gcattgtgga 1980 gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg 2040 gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc 2100 aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt 2160 gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt 2220 taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat 2280 gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtc cagaaagagg gaagggatga 2340 agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc 2400 tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa 2460 acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg 2520 ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat 2580 gtggcctgga gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga 2640 tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt 2700 ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag 2760 tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa 2820 atgcatattc caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca 2880 ctgcgcttct acagatactg gatgttttat tttaattaag ggcaatgcca gcgtaaagca 2940 taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgccggtgg 3000 gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt 3060 ttttgatcac aatgtgttga ccaagtgtac catgcatgca ggtgggcgta gaggaatgtt 3120 tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc 3180 cagaatgagc ctaacaggaa tctttgacat gaacatgcaa atctggaaga tcctgaggta 3240 tgatgatacg agatcgaggg tgcgcgcatg cgaatgcgga ggcaagcatg ccaggttcca 3300 gccggtgtgt gtagatgtga ctgaagatct gagaccggat catttggtta ttgcccgcac 3360 tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt 3420 ggggtggggt tttcagatgg acagattgag taaaaatttg ttttttctgt ctttcagctg 3480 tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540 tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600 tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660 cagctgcagc cgccgccgcc gcctctgttg ccgctaacac tgtgcttgga atgggttact 3720 atggaagtat cgtggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780 agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttatc 3840 agcaggtggc cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900 aaaaaaaaat tccacaatca atgaataaat aaacgagctt gttgttgatt taaaatcaag 3960 tgtttttatt tcatttttcg cgcacggtat gccctagacc accgatctcg atcattgaga 4020 acacggtgga ttttttccag aatcctatag aggtgggatt gaatgtttag atacatgggc 4080 attaggccat ctttggggtg gagatagctc cattgaaggg attcatgctc cggggtagtg 4140 ttgtaaatca cccagtcata acaaggtcgc agtgcatggt gttgcacaat atcttttaga 4200 agtaggctga ttgccacaga taagcccttg gtgtaggtgt ttacaaaccg gttgagctgg 4260 gaggggtgca ttcggggtga aattatgtgc attttggatt ggatttttaa gttggcaata 4320 ttgccgccaa gatctcgtct tgggttcatg ttatgaagga ccaccaagac ggtgtatccg 4380 gtacatttag gaaatttatc gtgtagcttg gatggaaaag cgtggaaaaa tttggagaca 4440 cccttgtgtc ctccgagatt ttccatgcac tcatccatga taatagcaat ggggccgtgg 4500 gcagcagcgc gggcaaacac gttccgtggg tctgacacat catagttatg ttcctgagtt 4560 aaatcatcat aagccatttt aatgaatttg gggcggagag tacccgattg gggtatgaat 4620 gttccttcgg gccccggagc atagttcccc tcacagattt gcatttccca agctttcagt 4680 tccgatggtg gaatcatgtc cacctggggg gctatgaaga acaccgtttc tggggcgggg 4740 gtgattagtt gggatgatag caagtttctg agcaattgag atttgccaca tccggtgggg 4800 ccataaatga ttccgattac aggttgcagg tggtagttta gggaacggca actgccgtct 4860 tctcgaagca agggggccac ctcgttcatc atttccctta catgcatatt ttcccgcacc 4920 aaatccatta ggaggcgctc tcctcctagt gatagaagtt cttgtagtga ggaaaagttt 4980 ttcagcggtt ttagaccgtc agccatgggc attttggaga gagtttgctg caaaagttct 5040 agtctgttcc acagttcagt gatgtgttct atggcatctc gatccagcag acctcctcgt 5100 ttcgcgggtt tggacggctc ctggagtagg gtatgagacg atgggcgtcc agcgctgcca 5160 gggttcggtc cttccagggt ctcagtgttc gagtcagggt tgtttccgtc acagtgaagg 5220 ggtgtgcgcc tgcttgggcg cttgccaggg tgcgcttcag actcattctg ctggtggaga 5280 acttctgtcg cttggcgccc tgtatgtcgg ccaagtagca gtttaccatg agttcgtagt 5340 tgagcgcctc ggctgcgtgg cctttggcgc ggagcttacc tttggaagtt ttcttgcata 5400 ccgggcagta taggcatttc agcgcataca gcttgggcgc aaggaaaatg gattctgggg 5460 agtatgcatc tgcgccgcag gaggcgcaaa cagtttcaca ttccaccagc caggttaaat 5520 ccggttcatt ggggtcaaaa acaagttttc cgccatattt tttgatgcgt ttcttacctt 5580 tggtctccat gagttcgtgt cctcgttgag tgacaaacag gctgtccgta tccccgtaga 5640 ctgattttac aggcctcttc tccagtggag tgcctcggtc ttcttcgtac aggaactctg 5700 accactctga tacaaaggcg cgcgtccagg ccagcacaaa ggaggctatg tgggaggggt 5760 agcgatcgtt gtcaaccagg gggtccacct tttccaaagt atgcaaacac atgtcaccct 5820 cttcaacatc caggaatgtg attggcttgt aggtgtattt cacgtgacct ggggtccccg 5880 ctgggggggt ataaaagggg gcggttcttt gctcttcctc actgtcttcc ggatcgctgt 5940 ccaggaacgt cagctgttgg ggtaggtatt ccctctcgaa ggcgggcatg acctctgcac 6000 tcaggttgtc agtttctaag aacgaggagg atttgatatt gacagtgccg gttgagatgc 6060 ctttcatgag gttttcgtcc atttggtcag aaaacacaat ttttttattg tcaagtttgg 6120 tggcaaatga tccatacagg gcgttggata aaagtttggc aatggatcgc atggtttggt 6180 tcttttcctt gtccgcgcgc tctttggcag cgatgttgag ttggacatac tcgcgtgcta 6240 ggcacttcca ttcggggaag atagttgtca attcatctgg cacgattctc acttgccacc 6300 ctcgattatg caaggtaatt aaatccacac tggtggccac ctcgcctcga aggggttcgt 6360 tggtccaaca gagcctacct cctttcctag aacagaaagg gggaagtggg tctagcataa 6420 gttcatcggg agggtctgca tccatggtaa agattcccgg aagtaaatcc ttatcaaaat 6480 agctgatggg agtggggtca tctaaggcca tttgccattc tcgagctgcc agtgcacgct 6540 catatgggtt aaggggactg ccccagggca tgggatgggt gagtgcagag gcatacatgc 6600 cacagatgtc atagacgtag atgggatcct caaagatgcc tatataggtt ggatagcatc 6660 gcccccctct gatacttgct cgcacatagt catatagttc atgtgatggc gctagcaacc 6720 ccggacccaa gttggtgcga ttgggttttt ctgttctgta gacaatctgg cgaaagatgg 6780 cgtgagaatt ggaagagatg gtgggtcttt gaaaaatgtt gaaatgggca tgaggtagac 6840 ctacagagtc tctgacaaag tgggcataag attcttgaag cttggttacc agttcggcgg 6900 tgacaagtac gtctagggcg cagtagtcaa gtgtttcttg aatgatgtca taacctggtt 6960 ggtttttctt ttcccacagt tcgcggttga gaaggtattc ttcgcgatcc ttccagtact 7020 cttctagcgg aaacccgtct ttgtctgcac ggtaagatcc tagcatgtag aactgattaa 7080 ctgccttgta agggcagcag cccttctcta cgggtagaga gtatgcttga gcagcttttc 7140 gcagcgaagc gtgagtaagg gcgaaggtgt ctctgaccat gactttgaga aattggtatt 7200 tgaagtccat gtcgtcacag gctccctgtt cccagagttg gaagtctacc cgtttcttgt 7260 aggcggggtt gggcaaagcg aaagtaacat cgttgaagag aatcttaccg gctctgggca 7320 taaaattgcg agtgatgcgg aaaggctgtg gtacttccgc tcgattgttg atcacctggg 7380 cagctaggac gatctcgtcg aaaccgttga tgttgtgtcc tacgatgtat aattctatga 7440 aacgcggcgt gcctttgacg tgaggtagct tattgagctc atcaaaggtt aggtctgtag 7500 ggtcagataa ggcgtagtgt tcgagagccc attcgtgcag gtgaggattt gcatgtagga 7560 atgatgacca aagatccacc gccagtgctg tttgtaactg gtcccgatac tgacgaaaat 7620 gctggccaat tgccattttt tctggagtga cacagtagaa ggttctgggg tcttgttgcc 7680 atcgatccca ctttagttta atggctagat cgtgggccat gttgacgaga cgctcttctc 7740 ctgagagttt catgaccagc atgaaaggaa ctagttgttt gccaaaggac cccatccagg 7800 tgtaagtttc cacatcgtag gtcaggaaga gtctttctgt gcgaggatga gagccgatcg 7860 ggaagaactg gatttcctgc caccagttgg aggattggct gttgatgtga tggaagtaga 7920 agtttctgcg gcgcgccgag cattcgtgtt tgtgcttgta cagacggccg cagtagtcgc 7980 agcgttgcac gggttgtatc tcgtgaatga gctgtacctg gcttcccttg acgagaaatt 8040 tcagtgggaa gccgaggcct ggcgattgta tctcgtgctc ttctatattc gctgtatcgg 8100 cctgttcatc ttctgtttcg gtggtggtca tgctgacgag cccccgcggg aggcaagtcc 8160 agacctcggc gcgggagggg cggagctgaa ggaccagagc gcgcaggctg gagctgtcca 8220 gagtcctgag acgctgcgga ctcaggttag taggtaggga cagaagatta acttgcatga 8280 tcttttccag ggcgtgcggg aggttcagat ggtacttgat ttccacaggt tcgtttgtag 8340 agatgtcaat ggcttgcagg gttccgtgtc ctttgggcgc cactaccgta cctttgtttt 8400 ttcttttgat cggtggtggc tctcttgctt cttgcatgct cagaagcgat gacggggacg 8460 cgcgccgggc ggaagcggtt gttccggacc cggaggcatg gctggtagtg gcacgtcggc 8520 gccgcgcacg ggcaggttct ggtactgcgc tctgagaaga cttgcgtgcg ccaccacgcg 8580 tcgattgacg tcttgtatct gacgtctctg ggtgaaagct accggccccg tgagcttgaa 8640 cctgaaagag agttcaacag aatcaatttc ggtatcgtta acggcagctt gtctcagtat 8700 ttcttgtacg tcaccagagt tgtcctggta ggcgatctcc gccatgaact gctcgatttc 8760 ttcctcctga agatctccgc gacccgctct ctcgacggtg gccgcgaggt cattggagat 8820 acggcccatg agttgggaga atgcagtcat gcccgcctcg ttccagacgc ggctgtaaac 8880 cacggccccc tcggagtctc ttgcgcgcat caccacctga gcgaggttaa gctccacgtg 8940 tctggtgaag accgcatagt tgcataggcg ctgaaaaagg tagttgagtg tggtggcaat 9000 gtgttcggcg acgaagaaat acatgatcca tcgtctcagc ggcatttcgc tgacatcgcc 9060 cagagcttcc aagcgctcca tggcctcgta gaagtccacg gcaaaattaa aaaactggga 9120 gtttcgcgcg gacacggtca attcctcctc gagaagacgg atgagttcgg ctatggtggc 9180 ccgtacttcg cgttcgaagg ctcccgggat ctcttcttcc tcttctatct cttcttccac 9240 taacatctct tcttcgtctt caggcggggg cggagggggc acacggcgac gtcgacggcg 9300 cacgggcaaa cggtcgatga atcgttcaat gacctctccg cggcggcggc gcatggtttc 9360 agtgacggcg cggccgttct cgcgcggtcg cagagtaaaa acaccgccgc gcatctcctt 9420 aaagtggtga ctgggaggtt ctccgtttgg gagggagagg gcgctgatta tacattttat 9480 taattggccc gtagggactg cgcgcagaga tctgatcgtg tcaagatcca cgggatctga 9540 aaacctttcg acgaaagcgt ctaaccagtc acagtcacaa ggtaggctga gtacggcttc 9600 ttgtgggcgg gggtggttat gtgttcggtc tgggtcttct gtttcttctt catctcggga 9660 aggtgagacg atgctgctgg tgatgaaatt aaagtaggca gttctaagac ggcggatggt 9720 ggcgaggagc accaggtctt tgggtccggc ttgctggata cgcaggcgat tggccattcc 9780 ccaagcatta tcctgacatc tagcaagatc tttgtagtag tcttgcatga gccgttctac 9840 gggcacttct tcctcacccg ttctgccatg catacgtgtg agtccaaacc cgcgcattgg 9900 ttgtaccagt gccaagtcag ctacgactct ttcggcgagg atggcttgct gtacttgggt 9960 gagggtggct tgaaagtcat caaaatccac aaagcggtgg taagccccgg tattaatggt 10020 gtaagcacag ttggccatga ctgaccagtt aactgtctgg tgaccagggc gcacgagctc 10080 ggtgtattta aggcgcgaat aggcgcgggt gtcaaagatg taatcgttgc aggtgcgcac 10140 cagatactgg taacctataa gaaaatgcgg cggtggttgg cggtagagag gccatcgttc 10200 tgtagctgga gcgccggggg cgaggtcttc caacataagg cggtgatagc cgtagatgta 10260 cctggacatc caggtgattc ctgcggcggt agtagaagcc cgaggaaact cgcgtacgcg 10320 gttccaaatg ttgcgtagcg gcatgaagta gttcattgta ggcacggttt gaccagtgag 10380 gcgcgcgcag tcattgatgc tctatagaca cggagaaaat gaaagcgttc agcgactcga 10440 ctccgtagcc tggaggaacg tgaacgggtt gggtcgcggt gtaccccggt tcgagacttg 10500 tactcgagcc ggccggagcc gcggctaacg tggtattggc actcccgtct cgacccagcc 10560 tacaaaaatc caggatacgg aatcgagtcg ttttgctggt tgccgaatgg cagggaagtg 10620 agtcctattt tttttttttg ccgctcagat gcatcccgtg ctgcgacaga tgcgtcccca 10680 acaacagccc ccctcgcagc agcagcaacc acaaaaggct gtccctgcaa ctactgcaac 10740 tgccgctgtg agcggtgcgg gacagcccgc ctatgatctg gacttggaag agggcgaagg 10800 actggcacgt ctaggtgcgc cttcgcccga gcggcatccg cgagttcaac tgaaaaaaga 10860 ttctcgcgag gcgtatgtgc cccaacagaa cctatttaga gacagaagcg gcgaggagcc 10920 ggaggagatg cgagcttccc gctttaacgc gggtcgtgag ctgcgtcacg gtttggacag 10980 aagacgagtg ttgcgggacg aggatttcga agttgatgaa gtgacaggga tcagtcctgc 11040 cagggcacac gtggctgcag ccaaccttgt atcggcttac gaacagacag taaaggaaga 11100 gcgtaatttc caaaagtctt ttaataatca tgtgcgaacc ctcattgccc gcgaagaagt 11160 cacccttggt ttgatgcatt tgtgggattt gatggaagct atcattcaga accctactag 11220 caaacctctg accgcacagc tgtttctggt ggtgcaacac agcagagaca atgaggcttt 11280 cagagaggcg ctgctcaaca tcaccgaacc cgaggggaga tggttgtatg atcttatcaa 11340 cattctacag agtatcatag tgcaggagcg gagcctgggc ctggccgaga aggtggctgc 11400 catcaattac tcggttttga gcttgggaaa gtattacgct cgcaagatct acaagactcc 11460 atacgttccc atagacaagg aggtgaagat agatgggttc tacatgcgca tgacgctgaa 11520 ggtgttgacc ctgagcgatg atcttggggt gtaccgcaat gacagaatgc atcgcgcggt 11580 gagcgccagc aggaggcgcg agttaagcga cagggaactg atgcacagtt tgcaaagagc 11640 tctaactgga gctggaaccg agggtgagaa ttactttgat atgggagctg acttgcagtg 11700 gcagcctagt cgcagggctc tgaacgccgc gacggcagga tgtgagcttc cttacataga 11760 agaggcggat gaaggcgagg aggaagaggg cgagtacttg gaagactgat ggcacaaccc 11820 gtgttttttg ctagatggaa cagcaagcac cggatcccgc aatgcgggcg gcgctgcaga 11880 gccagccgtc cggcattaac tcctcggacg attggaccca ggccatgcaa cgtatcatgg 11940 cgttgacgac tcgcaacccc gaagccttta gacagcaacc ccaggccaac cgtctatcgg 12000 ccatcatgga agctgtagtg ccttcccgct ctaatcccac tcatgagaag gtcctggcca 12060 tcgtgaacgc gttggtggag aacaaagcta ttcgtccaga tgaggccgga ctggtataca 12120 acgctctctt agaacgcgtg gctcgctaca acagtagcaa tgtgcaaacc aatttggacc 12180 gtatgataac agatgtacgc gaagccgtgt ctcagcgcga aaggttccag cgcgatgcca 12240 acctgggttc gctggtggcg ttaaatgctt tcttgagtac tcagcctgct aatgtgccgc 12300 gtggtcaaca ggattatact aactttttaa gtgctttgag actgatggta tcagaagtac 12360 ctcagagcga agtatatcag tccggtcctg attacttctt tcagactagc agacagggct 12420 tgcagacggt aaatctgagc caagctttta aaaaccttaa aggtttgtgg ggagtgcatg 12480 ccccggtagg agaaagagca accgtgtcta gcttgttaac tccgaactcc cgcctattat 12540 tactgttggt agctcctttc accgacagcg gtagcatcga ccgtaattcc tatttgggtt 12600 acctactaaa cctgtatcgc gaagccatag ggcaaagtca ggtggacgag cagacctatc 12660 aagaaattac ccaagtcagt cgcgctttgg gacaggaaga cactggcagt ttggaagcca 12720 ctctgaactt cttgcttacc aatcggtctc aaaagatccc tcctcaatat gctcttactg 12780 cggaggagga gaggatcctt agatatgtgc agcagagcgt gggattgttt ctgatgcaag 12840 agggggcaac tccgactgca gcactggaca tgacagcgcg aaatatggag cccagcatgt 12900 atgccagtaa ccgacctttc attaacaaac tgctggacta cttgcacaga gctgccgcta 12960 tgaactctga ttatttcacc aatgccatct taaacccgca ctggctgccc ccacctggtt 13020 tctacacggg cgaatatgac atgcccgacc ctaatgacgg atttctgtgg gacgacgtgg 13080 acagcgatgt tttttcacct ctttctgatc atcgcacgtg gaaaaaggaa ggcggcgata 13140 gaatgcattc ttctgcatcg ctgtccgggg tcattggtgc taccgcggct gagcccgagt 13200 ctgcaagtcc ttttcctagt ctaccctttt ctctacacag tgtacgtagc agcgaagtgg 13260 gtagaataag tcgcccgagt ttaatgggcg aagaggagta cctaaacgat tccttgctca 13320 gaccggcaag agaaaaaaat ttcccaaaca atggaataga aagtttggtg gataaaatga 13380 gtagatggaa gacttatgct caggatcaca gagacgagcc tgggatcatg gggactacaa 13440 gtagagcgag ccgtagacgc cagcgccatg acagacagag gggtcttgtg tgggacgatg 13500 aggattcggc cgatgatagc agcgtattgg acttgggtgg gagaggaagg ggcaacccgt 13560 ttgctcattt gcgccctcgc ttgggtggta tgttgtaaaa aaaaataaaa aagaaaaaac 13620 tcaccaaggc catggcgacg agcgtacgtt cgttcttctt tattatctgt gtctagtata 13680 atgaggcgag tcgtgctagg cggagcggtg gtgtatccgg agggtcctcc tccttcgtac 13740 gagagcgtga tgcagcagca gcaggcgacg gcggtgatgc aatccccact ggaggctccc 13800 tttgtgcctc cgcgatacct ggcacctacg gagggcagaa acagcattcg ttactcggaa 13860 ctggcacctc agtacgatac caccaggttg tatctggtgg acaacaagtc ggcggacatt 13920 gcttctctga actatcagaa tgaccacagc aacttcttga ccacggtggt gcaaaacaat 13980 gactttaccc ctacggaagc cagcacccag accattaact ttgatgaacg atcgcggtgg 14040 ggcggtcagc taaaaaccat catgcatact aacatgccca acgtgaacga gtatatgttt 14100 agtaacaagt tcaaagcgcg tgtgatggtg tccagaaaac ctcctgaggg tgttagagta 14160 gacgataatt atgatcataa gcaagatatt ctaaaatacg agtggttcga gtttactttg 14220 ccagaaggca acttttcggt cactatgact atcgacttga tgaacaatgc catcatagac 14280 aattacttga aagtgggcag acagaatgga gtgttggaaa gtgacattgg tgttaagttc 14340 gacactagga acttcaagtt gggatgggat ccagaaacta agttgatcat gcctggggtt 14400 tacacctatg aggccttcca tcctgacatc gtattgctgc ctggctgcgg agtggacttt 14460 accgaaagcc gtctgagcaa ccttcttggc attagaaaga aacacccatt ccaagagggt 14520 tttaagatct tgtatgagga tttagaagga ggaaatattc cagccctttt ggatgtagat 14580 gcttatgaga acagcaagaa agatcaaaaa gccaaaatag aagctgctgc agaagctaaa 14640 gcaaacatag ttgccaacga tccggtaagg gtggctaacg ctagtgaaat caggggagac 14700 agttttgccg caacatccgt tccgactaaa gaatcattat tggatgatgt gtctcaaaac 14760 atagagttaa aactcactat taagcctgtg gaaaaagatg gcaaaaacag aagttacaat 14820 gtgttggaag ataaaatcaa cacggcctat cgcagttggt acctttcgta caattatggc 14880 gaccccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt cacctgcgga 14940 gcggagcagg tctactggtc gcttccagac atgatgcagg atcctgtcac tttccgctcc 15000 actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt cttttcaaag 15060 agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac ctcgcttacg 15120 cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc gcccacaatt 15180 accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc gttgcgcagc 15240 agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac ctgtccctac 15300 gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac tttctaaaaa 15360 aaaaaaaaaa atgtccgttc ttatctcgcc cagtaataac accggttggg gtctgcgcgc 15420 tcccagcaag atgtacggag gcgcacgcaa acgttctacc caacatcccg tgcgtgttcg 15480 cgggcatttt cgcgctccat ggggtgccct caagggccgc actcgcgttc gaaccaccgt 15540 cgatgatgta atcgatcagg tggttgccga cgcccgtaat tatactccta ctgcgcctac 15600 atctactgtg gacgcagtta ttgacagtgt agtggctgac gctcgcaact atgctcgacg 15660 taagagccgg cgaaggcgca ttgccagacg tcaccgagct accactgcca tgcgagcagc 15720 aagagctctg ctacgaagag ctagacgcgt ggggcgaaga gccatgctta gggcggccag 15780 acgtgcagct tcgggcgcca gcgccggcag gtcccgcagg caagcagccg ctgtcgcagc 15840 ggcgactatt gccgacatgg cccaatcgcg aagaggcaat gtatactggg tgcgtgacgc 15900 tgccaccggt caacgtgtac ccgtgcgcac ccgtccccct cgcacttaga agatactgag 15960 cagtctccga tgttgtgtcc cagcggcgag gatgtccaag cgcaaataca aggaagaaat 16020 gctgcaggtt atcgcacctg aagtctacgg ccaaccgttg aaggatgaaa aaaaaccccg 16080 caaaatcaag cgggtaaaaa aggacaaaaa agaagaggaa gatggcgatg atgggctggc 16140 ggagtttgtg cgcgagtttg ccccacggcg acgcgtgcaa tggcgtgggc gcaaagttcg 16200 acatgtgttg agacctggaa cttcggtggt ctttacaccc ggcgagcgtt caagcgctac 16260 ttttaagcgt tcctatgatg aggtgtacgg ggatgatgat attcttgagc aggcagctga 16320 ccgattaggc gagtttgctt atggcaagcg tagtagaata aatcccaagg atgaaacagt 16380 gtccataccc ttggatcatg gaaatcccac ccctagtctt aaaccggtca ctttgcagca 16440 agtgttaccc gtaactccgc gaacaggtgt taaacgcgaa ggtgaagatt tgtatcccac 16500 tatgcaactg atggtgccca aacgccagaa gttggaggac gttttggaga aagtaaaagt 16560 ggatccagat attcaacctg aggttaaagt gagacccatt aagcaggtag cgcctggtct 16620 gggagtacaa actgtagaca ttaaaattcc cactgaaagt atggaagtgc aaactgaacc 16680 cgcaaagcct actgccacct ccactgaagt gcaaacggac ccatggatgc ccatgcctat 16740 tacaactgac gccgtcggtc ccactcgaag atcccgacga aagtacggtc cagcaagtct 16800 gttgatgccc aactatgtcg tacacccatc tattattcct actcctggtt accgaggcac 16860 tcgctactat cgcagccgaa acagtacttc ccgccgtcgc cgcaagacac ctgcaaatcg 16920 cagtcgtcgc cgtagacgca caagcaaacc gattcccggc gccctggtgc ggcaagtgta 16980 ccgcaatggt agtgcggaac ctttgacact gccgcgtgcg cgttaccatc ctagtatcat 17040 cacttaatca atgttgccgc tgcctccttg cagatatggc cctcacttgt cgccttcgcg 17100 ttcccatcac tggttaccga ggaagaaact cgcgccgtag aagagggatg ttggggcgcg 17160 gaatgcgacg ctacaggcga cggcgtgcta tccgcaagca attgcggggt ggttttttgc 17220 cagccttaat tccaattatc gctgctgcga ttggcgcaat accaggcata gcttccgtgg 17280 cggttcaggc ctcgcaacga cattgacatt ggaaaaaaaa aaaacgtata aataaaaaat 17340 acaatggact ctgacactcc tggtactgtg actatgtttt cttagagatg gaagacatca 17400 atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc tggagcgaca 17460 tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg agcgggctta 17520 aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc agtacaggac 17580 aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc gatgggatag 17640 cttccggtat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa aagataaaca 17700 gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa gaaattcctc 17760 cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg ctggtgacgc 17820 gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc accactagac 17880 cgatagcccc tatggccacc ggggtgatga aaccttctca gttgcatcga cccgtcacct 17940 tggatttgcc ccctcctcct gctgctactg ctgtacccgc ttctaagcct gtcgctgccc 18000 cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca aatgcacact 18060 ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa cgccgtcgct 18120 gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg tgtcattaca 18180 cgccgtcaca gcatcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg agttactttc 18240 aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc cggacaggat 18300 gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga cacctacttc 18360 aatctgggaa ataagtttag aaatcctacc gtagcgccga cccacgatgt gaccaccgat 18420 cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa tacatactct 18480 tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat ggccagcacg 18540 ttctttgaca ttaggggcgt gttggacaga ggtcccagtt ttaaacccta ttctggtacg 18600 gcttacaact ccctggctcc taaaggcgct ccaaatgcat ctcagtggtt ggataaggga 18660 gttacaagca ctggcctagt ggacgacggc aatactgatg atggggaaga agccaaaaaa 18720 gcaacataca cttttggtaa tgctccagta aaagccgagg ctgaaatcac aaaagacgga 18780 ttgccggtgg gcttggaagt ttcaactgaa ggtcctaaac caatctatgc tgataagctt 18840 tatcagccag aacctcaagt gggagacgaa acttggactg acctagacgg aaaaaccgaa 18900 gagtatggag ggagggttct taaacctgaa actaaaatga aaccctgcta cggatctttt 18960 gctaaaccta ctaatattaa aggaggtcag gcaaaggtaa aaccaaaaga agacgatggc 19020 actaacaaca tcgagtatga cattgacatg aacttctttg acttaagatc acaaagatca 19080 gaactcaaac ctaaaattgt aatgtatgca gaaaatgtgg acctggaatg tccagatact 19140 catgttgtgt acaaacctgg agtttcagat gctagttctg agaccaatct tggacaacag 19200 tctatgccca acagacccaa ctacattggc ttcagagata acttcatcgg acttatgtac 19260 tataacagta ctggcaacat gggggtactg gctggccaag cgtctcagtt gaatgcagtg 19320 gttgacttgc aggacagaaa cacagaactg tcttaccaac tcttgcttga ctctctgggc 19380 gacagaacca gatactttag catgtggaat caggctgtgg acagttatga tcctgatgta 19440 cgtgttattg aaaatcatgg tgtggaagat gaacttccca actattgttt tccgttggat 19500 ggtgtcggtc cgcgaacaga tagttacaag gagattaagc caaatggaga ccaatctact 19560 tggacaaatg tagacccaac tggcagcagt gaacttgcta agggaaatcc atttgccatg 19620 gaaattaacc ttcaagccaa tctatggcga agtttccttt attccaatgt ggctctatat 19680 ctcccagact cgtacaaata caccccgtcc aatgtcactc ttccagaaaa caaaaacacc 19740 tacgactaca tgaacgggcg ggtggtgccg ccatctctag tagacaccta tgtgaacatt 19800 ggtgccaggt ggtctctgga tgccatggac aatgtcaacc cattcaacca ccaccgtaac 19860 gctggcttgc gttaccgatc catgcttctg ggtaacggac gttatgtgcc tttccacata 19920 caagtgcctc aaaaattctt cgctgttaaa aacctgctgc ttctcccagg ctcctacact 19980 tatgagtgga actttaggaa ggatgtaaac atggttctac agagttccct cggtaacgac 20040 ctacgggtag atggcgccag catcagtttt acgagcatca acctctatgc tacttttttc 20100 cccatggctc acaacaccgc ttccaccctt gaagccatgc tgcggaatga caccaatgat 20160 cagtcattca acgactacct atctgcagct aacatgctct accccattcc tgccaatgca 20220 accaatattc ccatttccat tccttctcgc aactgggcgg ctttcagagg ctggtcattt 20280 accagactga aaaccaaaga aactccctct ttggggtctg gatttgaccc ctacttcgtc 20340 tattctggtt ctattcccta cctggatggt accttctacc tgaaccacac ttttaagaag 20400 gtttccatca tgtttgactc ttcagtgagc tggcctggaa atgacaggtt actatctcct 20460 aacgaatttg aaataaagcg cactgtggat ggcgaaggct acaacgtagc ccaatgcaac 20520 atgaccaaag actggttctt ggtacagatg ctcgccaact acaacatcgg ctatcagggc 20580 ttctacattc cagaaggata caaagatcgc atgtattcat ttttcagaaa cttccagccc 20640 atgagcaggc aggtggttga tgaggtcaat tacaaagact tcaaggccgt cgccataccc 20700 taccaacaca acaactctgg ctttgtgggt tacatggctc cgaccatgcg tcaaggtcaa 20760 ccctatcccg ctaactatcc ctatccactc attggaacaa ctgccgtaaa tagtgttacg 20820 cagaaaaagt tcttgtgtga cagaaccatg tggcgcatac cgttctcaag caacttcatg 20880 tctatgggag cccttacaga cttgggacag aacatgctct atgccaactc agctcatgct 20940 ctggacatga cctttgaggt ggatcccatg gatgagccca ccctgcttta tcttctcttc 21000 gaagttttcg acgtggtcag agtgcatcag ccacaccgcg gcatcatcga ggcagtctac 21060 ctgcgtacac cgttctcggc cggtaacgct accacgtaag aagcttcttg cttcttgcaa 21120 acagcagctg caaccatggc ctgcggatcc caaaacggct ccagcgagca agagctcaga 21180 gccattgtcc aagacctggg ttgcggacca tattttttgg gaacctttga taagcgcttc 21240 ccggggttca tggcccccga taagctcgcc tgtgccattg taaatacggc cggacgtgag 21300 acggggggag agcactggtt ggctttcggt tggaacccac gttctaacac ctgctacctt 21360 tttgatcctt ttggattctc ggatgatcgt ctcaaacaga tttaccagtt tgaatatgag 21420 ggtctcctgc gccgcagcgc tcttgctacc aaggaccggt gtattacgct ggaaaaatct 21480 acccagaccg tgcagggccc ccgttctgcc gcctgcggac ttttctgctg catgttcctt 21540 catgcctttg tgcactggcc tgaccgtccc atggacggaa accccaccat gaaattgcta 21600 actggagtgc caaacaacat gcttcattct cctaaagtcc agcccaccct gtgtgacaat 21660 caaaaagcac tctaccattt tctcaatacc cattcgcctt attttcgctc tcatcgtaca 21720 cacatcgaaa gggccactgc gttcgaccgt atggatgtgc aataatgatt catgtaaaca 21780 acgtgttcaa taaacagcac tttatttttt acatgtatcg aggctctgga ttacttattt 21840 atttacaagt cgaatgggtt ctgacgagaa tcagaatgac ccgcaggcag tgatacgttg 21900 cggaactgat acttgggttg ccacttgaat tcgggaatca ccaacttggg aaccggtata 21960 tcgggcagga tgtcactcca cagctttctg gtcagctgca aagctcccag caggtcagga 22020 gccgaaatct tgaaatcaca attaggacca gtgctctgag cgcgagagtt gcggtacacc 22080 ggattgcagc actgaaacac catcagcgac ggatgtctta cgcttgccag cacggtggga 22140 tctgcaatca tgcccacatc cagatcttca gcattggcaa tgctgaacgg ggtcatcttg 22200 caggtctgcc tacccatggc gggcacccaa ttaggcttgt ggttacaatc gcagtgcagg 22260 gggatcagta tcatcttggc ctgatcctgt ctgattcctg gatacacggc tctcatgaaa 22320 gcatcatatt gcttgaaagc ctgctgggct ttactaccct cggtataaaa catcccgcag 22380 gacctgctcg aaaactggtt agctgcgcag ccggcatcat tcacacagca gcgggcgtca 22440 ttgttggcta tttgcaccac acttctgccc cagcggtttt gggtgatttt ggttcgctcg 22500 ggattctcct tcaaggctcg ttgtccgttc tcgctggcca catccatctc gataatctgc 22560 tccttctgaa tcataatatt gccatgcaag cacttcagct tgccctcata atcattgcag 22620 ccatgaggcc acaacgcaca gcctgtacat tcccaattat ggtgggcgat ctgagaaaaa 22680 gaatgtatca ttccctgcag aaatcttccc atcatcgtgc tcagtgtctt gtgactagtg 22740 aaagttaact ggatgcctcg gtgctcctcg ttcacgtact ggtgacagat gcgcttgtat 22800 tgttcgtgct gctcaggcat tagtttaaaa gaggttctaa gttcgttatc cagcctgtac 22860 ttctccatca gcagacacat cacttccatg cctttctccc aagcagacac caggggcaag 22920 ctaatcggat tcttaacagt gcaggcagca gctcctttag ccagagggtc atctttggcg 22980 atcttctcaa tgcttctttt gccatccttc tcaacgatgc gcacgggcgg gtagctgaaa 23040 cccactgcta caagttgcgc ctcttctctt tcttcttcgc tgtcttgact gatgtcttgc 23100 atggggacat gtttggtctt ccttggcttc tttttcgggg gtatcggagg aggaggactg 23160 tcgctccgtt ccggagacag ggaggattgt gacgtttcgc tcaccattac caactgactg 23220 tcggtagaag aacctgaccc cacacggcga caggtgtttc tcttcggggg cagaggtgga 23280 ggcgattgcg aagggctgcg gtccgacctg gaaggcggat gactggcaga accccttccg 23340 cgttcggggg tgtgctccct gtggcggtcg cttaactgat ttccttcgcg gctggccatt 23400 gtgttctcct aggcagagaa acaacagaca tggaaactca gccattgctg tcaacatcgc 23460 cacgagtgcc atcacatctc gtcctcagcg acgaggaaaa ggagcagagc ttaagcattc 23520 caccgcccag tcctgccacc acctctaccc tagaagataa ggaggtcgac gcatctcatg 23580 acatgcagaa taaaaaagcg aaagagtctg agccagacat cgaacaagac ccgggctatg 23640 tgacaccggt ggaacacgag gaagagttga aacgctttct agagagagag gatgaaaact 23700 gcccaaaaca gcaagcggat aactatcacc aagatgctgg aaatagggat cagaacaccg 23760 actacctcat agggcttgac ggggaagacg cgctccttaa acatctagca agacagtcac 23820 tcatagtcaa ggatgcatta ttggacagaa ctgaagtgcc catcagtgtc gaagagctca 23880 gccgcgccta cgagcttaac ctattttcac ctcgtactcc ccccaaacgt cagccaaacg 23940 gcacctgcga gccaaatcct cgcttaaact tttatccagc ttttgctgtg ccagaagtac 24000 tggctaccta tcacatcttt tttaaaaatc aaaaaattcc agtctcctgc cgcgctaatc 24060 gcacccgcgc cgatgcccta ctcaatctgg gacctggttc acgcttacct gatatagctt 24120 ccttggaaga ggttccaaag atcttcgagg gtctgggcaa taatgagact cgggccgcaa 24180 atgctctgca aaagggagaa aatggcatgg atgagcatca cagcgttctg gtggaattgg 24240 aaggcgataa tgccagactc gcagtactca agcgaagcgt cgaggtcaca cactttgcat 24300 accccgctgt caacctgccc cctaaagtca tgacggccgt catggaccag ttactcatta 24360 agcgcgcaag tcccctttca gaagacatgc atgacccaga tgcctgtgat gagggtaaac 24420 cagtggtcag tgatgagcag ctaacccgat ggctgggcac cgactctccc cgggatttgg 24480 aagagcgtcg caagcttatg atggccgtgg tgctggttac cgtagaacta gagtgtcttc 24540 ggcgtttctt taccgattca gaaaccttgc gcaaactcga agagaatctg cactacactt 24600 ttagacacgg ctttgtgcgg caggcatgca agatatctaa cgtggaactc accaacctgg 24660 tttcctacat gggtattctg catgagaatc gcctaggaca aagcgtgctg cacagcaccc 24720 ttaaggggga agcccgccgt gattacatcc gcgattgtgt ttatctctac ctgtgccaca 24780 cgtggcaaac cggcatgggt gtatggcagc aatgtttaga agaacagaac ctgaaagagc 24840 taaacaagct cttacagaaa tctcttaagg ttctgtggac agggttcgac gagcgcaccg 24900 tcgcttccga cctggcagac ctcatcttcc cagagcgtct cagggttact ttgcgaaacg 24960 gactgcctga ctttatgagc cagagcatgc ttaacaattt tcgctctttc atcctggaac 25020 gctccggtat cctgcccgcc acctgctgcg cactgccctc cgactttgtg cctctcacct 25080 accgcgaatg ccccccgccg ctatggagtc actgctacct gttccgtctg gccaactacc 25140 tctcctacca ctcggatgtg atcgaggatg tgagcggaga cggcttgctg gagtgtcact 25200 gccgctgcaa tctgtgcacg ccccaccggt ccctagcttg caacccccag ttgatgagcg 25260 aaacccagat aataggcacc tttgaattgc aaggccccag cagccaaggc gatgggtctt 25320 ctcctgggca aagtttaaaa ctgaccccgg gactgtggac ctccgcctac ttgcgcaagt 25380 ttgccccgga agattaccac ccctatgaaa tcaagttcta tgaggaccaa tcacagcctc 25440 cgaaagccga actttcggcc tgcgtcatca cccagggggc aattctggcc caattgcaag 25500 ccatccaaaa atcccgccaa gaatttctac tgaaaaaggg taagggggtc taccttgacc 25560 cccagaccgg cgaggaactc aacacaaggt tccctcagga tgtcccaacg acgagaaagc 25620 aagaagttga aggtgcagcc gccgccccca gaagatatgg aggaagattg ggacagtcag 25680 gcagaggaag cggaggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag 25740 gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg 25800 gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt 25860 cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc 25920 ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc 25980 tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat 26040 ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat 26100 agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa 26160 accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac 26220 agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc 26280 catcttccag cagagtcggg gccaagagca ggaactgaaa ataaaaaacc gatctctgcg 26340 ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga 26400 ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac 26460 cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca 26520 cgccttacat gtggagttat cagccccaaa tgggattggc ggcaggcgcc tcccaggact 26580 actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata 26640 tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc 26700 aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca 26760 ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc 26820 agttagcggg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga 26880 tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac 26940 gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg 27000 ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc 27060 aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc 27120 actacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg 27180 attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg 27240 ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca 27300 ccctcaaggt ccggcccacg gagtgcggat tactatcgaa ggcaaaatac actctcgcct 27360 gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt 27420 ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg 27480 tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg 27540 gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct 27600 ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta 27660 ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg 27720 tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct 27780 acctatacac accttgcttc actttcctag tggtgttgtg gtattggttt aaaaaatggg 27840 gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga 27900 tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg 27960 catctgtgga gttcttatta agtgcggatg ggaatgcagg tccgttgaaa ttacacacaa 28020 taacaaaacc tggaacaata ccttatccac cacatgggag ccaggagttc ccgagtggta 28080 cactgtctct gtccgaggtc ctgacggttc catccgcatt agtaacaaca ctttcatttt 28140 ttctgaaatg tgcgatctgg ccatgttcat gagcaaacag tattctctat ggcctcctag 28200 caaggacaac atcgtaacgt tctccattgc ttattgcttg tgcgcttgcc ttcttactgc 28260 tttactgtgc gtatgcatac acctgcttgt aaccactcgc atcaaaaacg ccaataacaa 28320 agaaaaaatg ccttaacctc tttctgttta cagacatggc ttctcttaca tctctcatat 28380 ttgtcagcat tgtcactgcc gctcacggac aaacagtcgt ctctatccct ctaggacata 28440 attacactct cataggaccc ccaatcactt cagaggtcat ctggaccaaa ctgggaagcg 28500 ttgattactt tgatataatc tgcaacaaaa caaaaccaat aatagtaact tgcaacatac 28560 aaaatcttac attgattaat gttagcaaag tttacagcgg ttactattat ggttatgaca 28620 gatacagtag tcaatataga aattacttgg ttcgtgttac ccagttaaaa accacgaaaa 28680 tgccaaatat ggcaaagatt cgatccgatg acaattctct agaaactttt acatctccca 28740 ccacacccga cgaaaaaaac atcccagatt caatgattgc aattgttgca gcggtggcag 28800 tggtgatggc actaataata atatgcatgc ttttatatgc ttgtcgctac aaaaagtttc 28860 atcctaaaaa acaagatctc ctactaaggc ttaacattta atttcttttt atacagccat 28920 ggtttccact accacattcc ttatgcttac tagtcttgca actctgactt ctgctcgctc 28980 acacctcact gtaactatag gctcaaactg cacactaaaa ggacctcaag gtggtcatgt 29040 cttttggtgg agaatatatg acaatggatg gtttacaaaa ccatgtgacc aacctggtag 29100 atttttctgc aacggcagag acctaaccat tatcaacgtg acagcaaatg acaaaggctt 29160 ctattatgga accgactata aaagtagttt agattataac attattgtac tgccatctac 29220 cactccagca ccccgcacaa ctactttctc tagcagcagt gtcgctaaca atacaatttc 29280 caatccaacc tttgccgcgc ttttaaaacg cactgtgaat aattctacaa cttcacatac 29340 aacaatttcc acttcaacaa tcagcattat cgctgcagtg acaattggaa tatctattct 29400 tgtttttacc ataacctact acgcctgctg ctatagaaaa gacaaacata aaggtgatcc 29460 attacttaga tttgatattt aatttgttct tttttttttt atttacagta tggtgaacac 29520 caatcatggt acctagaaat ttcttcttca ccatactcat ttgtgcattt aatgtttgcg 29580 ctactttcac agcagtagcc acagcaaccc cagactgtat aggagcattt gcttcctatg 29640 cactttttgc ttttgttact tgcatctgcg tatgtagcat agtctgcctg gttattaatt 29700 ttttccaact tctagactgg atccttgtgc gaattgccta cctgcgccac catcccgaat 29760 accgcaacca aaatatcgcg gcacttctta gactcatcta aaaccatgca ggctatacta 29820 ccaatatttt tgcttctatt gcttccctac gctgtctcaa ccccagctgc ctatagtact 29880 ccaccagaac accttagaaa atgcaaattc caacaaccgt ggtcatttct tgcttgctat 29940 cgagaaaaat cagaaattcc cccaaattta ataatgattg ctggaataat taatataatc 30000 tgttgcacca taatttcatt tttgatatac cccctatttg attttggctg gaatgctccc 30060 aatgcacatg atcatccaca agacccagag gaacacattc ccctacaaaa catgcaacat 30120 ccaatagcgc taatagatta cgaaagtgaa ccacaacccc cactactccc tgctattagt 30180 tacttcaacc taaccggcgg agatgactga aacactcacc acctccaatt ccgccgagga 30240 tctgctcgat atggacggcc gcgtctcaga acagcgactt gcccaactac gcatccgcca 30300 gcagcaggaa cgcgcggcca aagagctcag agatgtcatc caaattcacc aatgcaaaaa 30360 aggcatattc tgtttggtaa aacaagccaa gatatcctac gagatcaccg ctactgacca 30420 tcgcctctct tacgaacttg gcccccaacg acaaaaattt acctgcatgg tgggaatcaa 30480 ccccatagtt atcacccagc aaagtggaga tactaagggt tgcattcact gctcctgcga 30540 ttccatcgag tgcacctaca ccctgctgaa gaccctatgc ggcctaagag acctgctacc 30600 aatgaattaa aaaatgatta ataaaaaatc acttacttga aatcagcaat aaggtctctg 30660 ttgaaatttt ctcccagcag cacctcactt ccctcttccc aactctggta ttctaaaccc 30720 cgttcagcgg catactttct ccatacttta aaggggatgt caaattttag ctcctctcct 30780 gtacccacaa tcttcatgtc tttcttccca gatgaccaag agagtccggc tcagtgactc 30840 cttcaaccct gtctacccct atgaagatga aagcacctcc caacacccct ttataaaccc 30900 agggtttatt tccccaaatg gcttcacaca aagcccagac ggagttctta ctttaaaatg 30960 tttaacccca ctaacaacca caggcggatc tctacagcta aaagtgggag ggggacttac 31020 agtggatgac actgatggta ccttacaaga aaacatacgt gctacagcac ccattactaa 31080 aaataatcac tctgtagaac tatccattgg aaatggatta gaaactcaaa acaataaact 31140 atgtgccaaa ttgggaaatg ggttaaaatt taacaacggt gacatttgta taaaggatag 31200 tattaacacc ttatggactg gaataaaccc tccacctaac tgtcaaattg tggaaaacac 31260 taatacaaat gatggcaaac ttactttagt attagtaaaa aacggagggc ttgttaatgg 31320 ctacgtgtct ctagttggtg tatcagacac tgtgaaccaa atgttcacac aaaagacagc 31380 aaacatccaa ttaagattat attttgactc ttctggaaat ctattaactg atgaatcaga 31440 cttaaaaatt ccacttaaaa ataaatcttc tacagcgacc agtgaaactg tagccagcag 31500 caaagccttt atgccaagta ctacagctta tcccttcaac accactacta gggatagtga 31560 aaactacatt catggaatat gttactacat gactagttat gatagaagtc tatttccctt 31620 gaacatttct ataatgctaa acagccgtat gatttcttcc aatgttgcct atgccataca 31680 atttgaatgg aatctaaatg caagtgaatc tccagaaagc aacatagcta cgctgaccac 31740 atcccccttt ttcttttctt acattacaga agacgacaac taaaataaag tttaagtgtt 31800 tttatttaaa atcacaaaat tcgagtagtt attttgcctc caccttccca tttgacagaa 31860 tacaccaatc tctccccacg cacagcttta aacatttgga taccattaga gatagacatt 31920 gttttagatt ccacattcca aacagtttca gagcgagcca atctggggtc agtgatagat 31980 aaaaatccat cgcgatagtc ttttaaagcg ctttcacagt ccaactgctg cggatgcgaa 32040 tccggagtct ggatcacggt catctggaag aagaacgatg ggaatcataa tccgaaaacg 32100 gtatcggacg attgtgtctc atcaaaccca caagcagccg ctgtctgcgt cgctccgtgc 32160 aactgctgtt tatgggatca gggtccacag tgtcctgaag catgatttta atagccctta 32220 acatcaactt tctggtgcga tgcgcgcagc aacgcattct gatttcactc aaatctttgc 32280 agtaggtaca acacattatt acaatattgt ttaataaacc ataattaaaa gcgctccagc 32340 caaaactcat atctgatata atcgcccctg catgaccatc ataccaaagt ttaatataaa 32400 ttaaatgacg ttccctcaaa aacacactac ccacatacat gatctctttt ggcatgtgca 32460 tattaacaat ctgtctgtac catggacaac gttggttaat catgcaaccc aatataacct 32520 tccggaacca cactgccaac accgctcccc cagccatgca ttgaagtgaa ccctgctgat 32580 tacaatgaca atgaagaacc caattctctc gaccgtgaat cacttgagaa tgaaaaatat 32640 ctatagtggc acaacataga cataaatgca tgcatcttct cataattttt aactcctcag 32700 gatttagaaa catatcccag ggaataggaa gctcttgcag aacagtaaag ctggcagaac 32760 aaggaagacc acgaacacaa cttacactat gcatagtcat agtatcacaa tctggcaaca 32820 gcgggtggtc ttcagtcata gaagctcggg tttcattttc ctcacaacgt ggtaactggg 32880 ctctggtgta agggtgatgt ctggcgcatg atgtcgagcg tgcgcgcaac cttgtcataa 32940 tggagttgct tcctgacatt ctcgtatttt gtatagcaaa acgcggccct ggcagaacac 33000 actcttcttc gccttctatc ctgccgctta gcgtgttccg tgtgatagtt caagtacagc 33060 cacactctta agttggtcaa aagaatgctg gcttcagttg taatcaaaac tccatcgcat 33120 ctaattgttc tgaggaaatc atccacggta gcatatgcaa atcccaacca agcaatgcaa 33180 ctggattgcg tttcaagcag gagaggagag ggaagagacg gaagaaccat gttaattttt 33240 attccaaacg atctcgcagt acttcaaatt gtagatcgcg cagatggcat ctctcgcccc 33300 cactgtgttg gtgaaaaagc acagctaaat caaaagaaat gcgattttca aggtgctcaa 33360 cggtggcttc caacaaagcc tccacgcgca catccaagaa caaaagaata ccaaaagaag 33420 gagcattttc taactcctca atcatcatat tacattcctg caccattccc agataatttt 33480 cagctttcca gccttgaatt attcgtgtca gttcttgtgg taaatccaat ccacacatta 33540 caaacaggtc ccggagggcg ccctccacca ccattcttaa acacaccctc ataatgacaa 33600 aatatcttgc tcctgtgtca cctgtagcga attgagaatg gcaacatcaa ttgacatgcc 33660 cttggctcta agttcttctt taagttctag ttgtaaaaac tctctcatat tatcaccaaa 33720 ctgcttagcc agaagccccc cgggaacaag agcaggggac gctacagtgc agtacaagcg 33780 cagacctccc caattggctc cagcaaaaac aagattggaa taagcatatt gggaaccgcc 33840 agtaatatca tcgaagttgc tggaaatata atcaggcaga gtttcttgta aaaattgaat 33900 aaaagaaaaa tttgccaaaa aaacattcaa aacctctggg atgcaaatgc aataggttac 33960 cgcgctgcgc tccaacattg ttagttttga attagtctgc aaaaataaaa aaaaaaacaa 34020 gcgtcatatc atagtagcct gacgaacagg tggataaatc agtctttcca tcacaagaca 34080 agccacaggg tctccagctc gaccctcgta aaacctgtca tggtgattaa acaacagcac 34140 cgaaagttcc tcgcggtgac cagcatgaat aattcttgat gaagcataca atccagacat 34200 gttagcatca gttaacgaga aaaaacagcc aacatagcct ttgggtataa ttatgcttaa 34260 tcgtaagtat agcaaagcca cccctcgcgg atacaaagta aaaggcacag gagaataaaa 34320 aatataatta tttctctgct gctgttcagg caacgtcgcc cccggtccct ctaaatacac 34380 atacaaagcc tcatcagcca tggcttacca gacaaagtac agcgggcacg cacaagctct 34440 aaagtcactc tccaacctct ccacaatata tatacacaag ccctaaactg acgtaatggg 34500 agtaaagtgt aaaaaatccc gccaaaccca acacacaccc cgaaactgcg tcaccaggga 34560 aaagtacagt ttcacttccg caatcccaac aagcgtcact tcctctttct cacggtacgt 34620 cacatcccat taacttgcaa cgtcattttc ccacggccgc gccgccccgt ttagccgtta 34680 accccacagc caatcaccac acaccccaca atttttaaaa tcacctcatt tacatattgg 34740 caccattcca tctataaggt atattattga tgatg 34775

Claims (16)

1. 재조합 아데노바이러스를 제조하는 방법으로서,
   서열 및 결찰 독립 클로닝(SLIC: sequence and ligation independent cloning)에 의해 하이브리드화 가능 아데노바이러스 목적 벡터 골격을 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈과 조합함으로써 아데노바이러스 게놈을 조립하는 단계로서, 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈은 E2-L2 모듈, L3-L4 모듈, E2-L4 모듈, E1 모듈, E3 모듈, E4 모듈 또는 이들의 조합을 포함하는 단계를 포함하는 제조 방법.
2. 제1항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격은 E2-L2 모듈, L3-L4 모듈, E2-L2 모듈과 L3-L4 모듈 둘 다, 또는 E2-L4 모듈을 포함하는 아데노바이러스 코어 모듈 목적 벡터이고; 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈은 E1 모듈, E3 모듈, E4 모듈, 또는 이들의 임의 조합을 포함하는 것인 제조 방법.
3. 제1항 또는 제2항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격은 p15A 복제 기점을 포함하는 것인 제조 방법.
4. 제1항 내지 제3항 중 어느 한 항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격은 포유동물 I-SceI 발현 카세트를 포함하는 것인 제조 방법.
5. 제2항 내지 제4항 중 어느 한 항에 있어서, 코어 모듈은 길이가 12 kb 이상인 제조 방법.
6. 제2항 내지 제4항 중 어느 한 항에 있어서, 코어 모듈은 길이가 14 kb 이상인 제조 방법.
7. 제2항 내지 제6항 중 어느 한 항에 있어서, 코어 모듈은 E2-L2 모듈 및 L3-L4 모듈을 포함하는 것인 제조 방법.
8. 제2항 내지 제6항 중 어느 한 항에 있어서, 코어 모듈은 E2-L4 모듈을 포함하는 것인 제조 방법.
9. 제1항 내지 제8항 중 어느 한 항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격 및 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈은 길이 약 20 내지 약 25 염기 쌍의 단일 가닥 핵산 오버행을 포함하는 것인 제조 방법.
10. 제9항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격 및 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈은 각 말단 상에 단일 가닥 핵산 오버행을 포함하는 것인 제조 방법.
11. 제1항 내지 제10항 중 어느 한 항에 있어서, 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈은
    환형이거나 환형 플라스미드 내에 함유되는 아데노바이러스 유전자 모듈을 엔도뉴클레아제와 접촉시켜 선형 아데노바이러스 유전자 모듈을 형성하는 단계; 및
    선형 아데노바이러스 유전자 모듈을 엑소뉴클레아제와 접촉시켜 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈을 형성하는 단계
    에 의해 형성되는 것인 제조 방법.
12. 제1항 내지 제11항 중 어느 한 항에 있어서, 하이브리드화 가능 아데노바이러스 목적 벡터 골격은
    환형 목적 벡터 골격을 엔도뉴클레아제와 접촉시켜 선형 목적 벡터 골격을 형성하는 단계; 및
    선형 목적 벡터 골격을 엑소뉴클레아제와 접촉시켜 하이브리드화 가능 목적 벡터 골격을 형성하는 단계
    에 의해 형성되는 것인 제조 방법.
13. 제1항 내지 제12항 중 어느 한 항에 있어서, 아데노바이러스 게놈을 세포 내에 형질감염시키는 단계를 더 포함하는 제조 방법.
14. 제1항 내지 제13항 중 어느 한 항에 있어서, 아데노바이러스 게놈은 세포에서 발현될 때 재조합 아데노바이러스를 형성할 수 있는 것인 제조 방법.
15. 제1항 내지 제14항 중 어느 한 항에 있어서, 아데노바이러스 게놈은 보충 세포주에서 발현될 때 또는 헬퍼 바이러스와 함께 세포에서 발현될 때 재조합 아데노바이러스를 형성할 수 있는 아데노바이러스 게놈 구성체의 일부인 것인 제조 방법.
16. 제1항 내지 제15항 중 어느 한 항에 있어서, 하나 이상의 하이브리드화 가능 아데노바이러스 유전자 모듈 중 하나 이상이 이러한 유전자 모듈이 유래하는 야생형 아데노바이러스에 비해 하나 이상의 변형을 포함하는 것인 제조 방법.
    

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