CN106999501B - 奥那司酮延长释放组合物和方法 - Google Patents

奥那司酮延长释放组合物和方法 Download PDF

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Publication number
CN106999501B
CN106999501B CN201580062192.1A CN201580062192A CN106999501B CN 106999501 B CN106999501 B CN 106999501B CN 201580062192 A CN201580062192 A CN 201580062192A CN 106999501 B CN106999501 B CN 106999501B
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China
Prior art keywords
onapristone
extended release
cancer
pharmaceutical composition
human subject
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Expired - Fee Related
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CN201580062192.1A
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English (en)
Chinese (zh)
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CN106999501A (zh
Inventor
亚历山大·祖基武斯基
斯特凡·普罗纽克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kangtai Cascade Pharmaceutical Co ltd
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Arno Therapeutics Inc
Kangtai Cascade Pharmaceutical Co ltd
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Priority to CN202110852562.9A priority Critical patent/CN113559075A/zh
Publication of CN106999501A publication Critical patent/CN106999501A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580062192.1A 2014-11-17 2015-11-16 奥那司酮延长释放组合物和方法 Expired - Fee Related CN106999501B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110852562.9A CN113559075A (zh) 2014-11-17 2015-11-16 奥那司酮延长释放组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080868P 2014-11-17 2014-11-17
US62/080,868 2014-11-17
PCT/US2015/060940 WO2016081383A1 (en) 2014-11-17 2015-11-16 Onapristone extended-release compositions and methods

Related Child Applications (1)

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CN202110852562.9A Division CN113559075A (zh) 2014-11-17 2015-11-16 奥那司酮延长释放组合物和方法

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CN106999501A CN106999501A (zh) 2017-08-01
CN106999501B true CN106999501B (zh) 2021-08-13

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CN202110852562.9A Pending CN113559075A (zh) 2014-11-17 2015-11-16 奥那司酮延长释放组合物和方法

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US (3) US10786461B2 (enExample)
EP (1) EP3247362A4 (enExample)
JP (1) JP6655075B2 (enExample)
KR (1) KR20170084086A (enExample)
CN (2) CN106999501B (enExample)
AU (2) AU2015350241B2 (enExample)
CA (1) CA2966753A1 (enExample)
HK (1) HK1246653A1 (enExample)
MX (1) MX391191B (enExample)
RU (1) RU2017112748A (enExample)
WO (1) WO2016081383A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2966753A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
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CA3008422A1 (en) 2015-12-15 2017-06-22 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
US20180148471A1 (en) 2016-11-30 2018-05-31 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

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Also Published As

Publication number Publication date
CN106999501A (zh) 2017-08-01
WO2016081383A1 (en) 2016-05-26
EP3247362A1 (en) 2017-11-29
JP2017537883A (ja) 2017-12-21
US20230157960A1 (en) 2023-05-25
AU2015350241B2 (en) 2021-05-20
US20160166583A1 (en) 2016-06-16
RU2017112748A3 (enExample) 2019-06-26
MX2017005163A (es) 2018-01-18
CA2966753A1 (en) 2016-05-26
US20210220279A1 (en) 2021-07-22
US10786461B2 (en) 2020-09-29
AU2015350241A1 (en) 2017-05-04
KR20170084086A (ko) 2017-07-19
CN113559075A (zh) 2021-10-29
EP3247362A4 (en) 2018-10-10
HK1246653A1 (zh) 2018-09-14
US11672762B2 (en) 2023-06-13
AU2021218093A1 (en) 2021-09-09
MX391191B (es) 2025-03-21
JP6655075B2 (ja) 2020-02-26
RU2017112748A (ru) 2018-12-19

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