CN106963661B - Hexagon firming essence liquid and preparation method thereof - Google Patents
Hexagon firming essence liquid and preparation method thereof Download PDFInfo
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- CN106963661B CN106963661B CN201710229347.7A CN201710229347A CN106963661B CN 106963661 B CN106963661 B CN 106963661B CN 201710229347 A CN201710229347 A CN 201710229347A CN 106963661 B CN106963661 B CN 106963661B
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/673—Vitamin B group
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to a hexapeptide tightening essence stock solution and a preparation method thereof. The hexakispeptide firming essence stock solution comprises propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer, triethanolamine, panthenol, nicotinamide, hexakispeptide, hydrolyzed collagen, dipotassium glycyrrhizinate, phenoxyethanol and water. Has the effects of moisturizing, keeping warm, tightening skin, eliminating fine lines, and brightening and tightening skin.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a hexapeptide tightening essence stock solution and a preparation method thereof.
Background
With aging, long-term exposure to adverse environmental factors or malnutrition, the visual appearance, physical properties and physiological functions of the skin change, the number of fibroblasts in the human body gradually decreases, and thus the secreted collagen and elastin gradually decrease and break due to oxidation, the dermis layer begins to become thin, the skin elasticity deteriorates, and wrinkles gradually develop.
The hexapeptide is a botulinum toxin-like component, has all functions of botulinum toxin, does not contain any toxicity, and is a non-toxic substance. The main component is a biochemical product formed by arranging and combining six amino acids, although the biochemical product is usually compared with botulism, the mechanisms of the biochemical product are completely different, and the hexapeptide can intercept muscle contraction signals, relieve the force of muscle contraction and further improve the depth and the length of fine wrinkles. The hexapeptide is used in cosmetics as an anti-wrinkle component and has an excellent effect.
The cosmetics in the market at present are various, but the effect is single, and a product which is good in moisturizing effect, can tighten skin and eliminate fine lines is difficult to find.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the hexapeptide tightening essence stock solution which is good in moisturizing effect and capable of tightening skin and eliminating fine wrinkles and the preparation method thereof.
The technical scheme adopted by the invention is as follows:
the hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight:
1-5 parts of propylene glycol, 1-5 parts of butanediol, 0.01-0.1 part of EDTA disodium, 0.01-0.3 part of allantoin, 0.01-0.3 part of hydroxyethyl cellulose, 0.01-0.05 part of hyaluronic acid, 0.05-0.3 part of carbomer, 0.05-0.3 part of triethanolamine, 0.1-1 part of nicotinamide, 0.1-1 part of hexapeptide, 0.05-1 part of phenoxyethanol and 80-100 parts of water.
The invention also provides a preparation method of the hexapeptide tightening essence stock solution, which comprises the following steps:
step 1, adding propylene glycol, butanediol, disodium EDTA, allantoin, hydroxyethyl cellulose, hyaluronic acid, carbomer and triethanolamine into a water phase pot, and adding water to obtain a first mixture;
step 2, adding nicotinamide into the first mixture obtained in the step 1, stirring and neutralizing until the mixture is completely transparent to obtain a second mixture;
and 3, adding the hexapeptide and phenoxyethanol into the second mixture obtained in the step 2, and uniformly stirring to obtain the hexapeptide tightening essence stock solution.
Further, the hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 1-5 parts of propylene glycol, 1-5 parts of butanediol, 0.01-0.1 part of EDTA disodium, 0.01-0.3 part of allantoin, 0.01-0.3 part of hydroxyethyl cellulose, 0.01-0.3 part of xanthan gum, 0.1-5 parts of betaine, 0.01-0.05 part of hyaluronic acid, 0.5-3 parts of trehalose, 0.05-0.3 part of carbomer, 0.05-0.3 part of triethanolamine, 0.1-1 part of panthenol, 0.1-1 part of nicotinamide, 0.1-1 part of hexapeptide, 0.5-3 part of hydrolyzed collagen, 0.01-0.5 part of dipotassium glycyrrhizinate, 0.05-1 part of phenoxyethanol and 80-100 parts of water.
Further, the hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2-3 parts of propylene glycol, 2-3 parts of butanediol, 0.02-0.08 part of EDTA disodium, 0.05-0.2 part of allantoin, 0.05-0.2 part of hydroxyethyl cellulose, 0.05-0.2 part of xanthan gum, 1-3 parts of betaine, 0.02-0.04 part of hyaluronic acid, 1-2 parts of trehalose, 0.1-0.2 part of carbomer, 0.1-0.2 part of triethanolamine, 0.3-0.8 part of panthenol, 0.3-0.8 part of nicotinamide, 0.2-0.5 part of hexapeptide, 1-2 parts of hydrolyzed collagen, 0.05-0.3 part of dipotassium glycyrrhizinate, 0.1-0.5 part of phenoxyethanol and 85-90 parts of water.
Further, the hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5 parts of propylene glycol, 2.5 parts of butanediol, 0.05 part of EDTA disodium, 0.1 part of allantoin, 0.1 part of hydroxyethyl cellulose, 0.1 part of xanthan gum, 2 parts of betaine, 0.03 part of hyaluronic acid, 1.2 parts of trehalose, 0.15 part of carbomer, 0.15 part of triethanolamine, 0.5 part of panthenol, 0.5 part of nicotinamide, 0.3 part of hexapeptide, 1.5 parts of hydrolyzed collagen, 0.1 part of dipotassium glycyrrhizinate, 0.2 part of phenoxyethanol and 88.02 parts of water.
Further, the hexapeptide is hexapeptide-1.
The invention also provides a preparation method of the hexapeptide tightening essence stock solution, which comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, and adding water to obtain a first mixture;
step 2, adding panthenol and nicotinamide into the first mixture obtained in the step 1, stirring and neutralizing until the mixture is completely transparent to obtain a second mixture;
and 3, adding the hexapeptide, the hydrolyzed collagen, the dipotassium glycyrrhizinate and the phenoxyethanol into the second mixture obtained in the step 2, and uniformly stirring to obtain the hexapeptide tightening essence stock solution.
Further, in the step 1, the obtained first mixture is heated to 80-90 ℃ while stirring, and is stirred for 20-40min at constant temperature until no particles are dissolved.
Further, in step 2, the first mixture obtained in step 1 is cooled to 50-60 ℃, and then panthenol and nicotinamide are added. The cooling is to start cooling water for cooling.
Further, in step 3, the second mixture obtained in step 2 is cooled to 30-40 ℃, and then the hexapeptide, the hydrolyzed collagen, the dipotassium glycyrrhizinate and the phenoxyethanol are added.
And further, sampling, detecting and packaging before the hexapeptide tightening essence stock solution in the step 3 is obtained.
The hexapeptide can inhibit nerve conduction substances, block the conduction function between nerve muscles, avoid over contraction of muscles and prevent fine wrinkles from forming. The hexatomic peptide can reduce the force for relieving muscle contraction, relax muscles, reduce the occurrence of dynamic wrinkles and eliminate fine wrinkles; effectively reorganizes the elasticity of collagen, can increase the activity of elastin, relaxes the lines of the face, and smoothes wrinkles and improves laxity. Can be used in cosmetics as an anti-wrinkle component with excellent effect.
Hyaluronic acid can carry more than 500 times of water, is the best moisture-preserving component recognized at present, and is widely applied to maintenance products and cosmetics. Can improve joint function, is a natural moisturizing lubricant, and can prevent arteriosclerosis, pulse disorder, brain atrophy, etc.
Hydrolyzed collagen refers to hydrolyzed collagen peptide, also called hydrolyzed collagen, is a natural biological product, is rich in various bioactive substances such as polypeptide and the like necessary for human metabolism, particularly rich in hydroxyproline (> 12%) necessary for cartilage, skin and hair metabolism, and is the main material basis of connective tissue. Has effects in inhibiting melanin and whitening skin; acting on the dermis layer to delay aging; improving microcirculation, removing speckle and wrinkle; shrinking pores, supplementing water and preserving heat; tightening skin and repairing fine wrinkles; removing black eye and eliminating eye bags; skin lightening, firming and aging reversing; removing striae gravidarum, and improving allergic constitution; reducing weight; enlarging breast and caring skin.
The invention has the beneficial effects that: the hexapeptide tightening essence stock solution provided by the invention contains substances capable of removing wrinkles and tightening the skin, such as hexapeptide, hyaluronic acid, hydrolyzed collagen and the like; adding skin conditioning agent such as panthenol, nicotinamide, dipotassium glycyrrhizinate and allantoin; the hexapeptide tightening essence stock solution is prepared by adding moisturizing substances such as propylene glycol, butanediol and betaine in a scientific compatibility manner, and has the effects of moisturizing, preserving heat, tightening skin, eliminating fine wrinkles, brightening skin and tightening skin.
Detailed Description
The present invention will be described in more detail with reference to examples.
Example 1
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 1g of propylene glycol, 1g of butanediol, 0.01g of disodium EDTA, 0.01g of allantoin, 0.01g of hydroxyethyl cellulose, 0.01g of xanthan gum, 0.1g of betaine, 0.01g of hyaluronic acid, 0.5g of trehalose, 0.05g of carbomer, 0.05g of triethanolamine, 0.1g of panthenol, 0.1g of nicotinamide, 0.1g of hexapeptide-1, 0.5g of hydrolyzed collagen, 0.01g of dipotassium glycyrrhizinate, 0.05g of phenoxyethanol and 80g of water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 80 ℃ while stirring, and stirring at constant temperature for 20min until no particles are dissolved;
step 2, starting cooling water to cool to 50 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 30 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Example 2
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 5g propylene glycol, 5g butanediol, 0.1g disodium EDTA, 0.3g allantoin, 0.3g hydroxyethylcellulose, 0.3g xanthan gum, 5g betaine, 0.05g hyaluronic acid, 3g trehalose, 0.3g carbomer, 0.3g triethanolamine, 1g panthenol, 0.1-1g nicotinamide, 1g hexapeptide-1, 3g hydrolyzed collagen, 0.5g dipotassium glycyrrhizinate, 1g phenoxyethanol, and 100g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 90 ℃ while stirring, and stirring at constant temperature for 40min until no particles are dissolved;
step 2, starting cooling water to cool to 60 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 40 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Example 3
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2g of propylene glycol, 2g of butanediol, 0.02g of disodium EDTA, 0.05g of allantoin, 0.05g of hydroxyethylcellulose, 0.05g of xanthan gum, 1g of betaine, 0.02g of hyaluronic acid, 1g of trehalose, 0.1g of carbomer, 0.1g of triethanolamine, 0.3g of panthenol, 0.3-0.8g of nicotinamide, 0.2g of hexapeptide-1, 1g of hydrolyzed collagen, 0.05g of dipotassium glycyrrhizinate, 0.1g of phenoxyethanol and 85g of water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Example 4
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 3g propylene glycol, 3g butylene glycol, 0.08g disodium EDTA, 0.2g allantoin, 0.2g hydroxyethylcellulose, 0.2g xanthan gum, 3g betaine, 0.04g hyaluronic acid, 2g trehalose, 0.2g carbomer, 0.2g triethanolamine, 0.8g panthenol, 0.8g nicotinamide, 0.5g hexapeptide-1, 2g hydrolyzed collagen, 0.3g dipotassium glycyrrhizinate, 0.5g phenoxyethanol, and 90g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Example 5
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 2.5g butylene glycol, 0.05g disodium EDTA, 0.1g allantoin, 0.1g hydroxyethylcellulose, 0.1g xanthan gum, 2g betaine, 0.03g hyaluronic acid, 1.2g trehalose, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 0.3g hexapeptide-1, 1.5g hydrolyzed collagen, 0.1g dipotassium glycyrrhizinate, 0.2g phenoxyethanol, and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Comparative example 1
The tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 2.5g butylene glycol, 0.05g disodium EDTA, 0.1g allantoin, 0.1g hydroxyethylcellulose, 0.1g xanthan gum, 2g betaine, 0.03g hyaluronic acid, 1.2g trehalose, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 1.5g hydrolyzed collagen, 0.1g dipotassium glycyrrhizinate, 0.2g phenoxyethanol, and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Comparative example 2
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 2.5g butylene glycol, 0.05g disodium EDTA, 0.1g allantoin, 0.1g hydroxyethyl cellulose, 0.1g xanthan gum, 2g betaine, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 0.3g hexapeptide-1, 1.5g hydrolyzed collagen, 0.1g dipotassium glycyrrhizinate, 0.2g phenoxyethanol, and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hexapeptide-1, hydrolyzed collagen, dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after qualified detection to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Comparative example 3
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 2.5g butylene glycol, 0.05g disodium EDTA, 0.1g allantoin, 0.1g hydroxyethylcellulose, 0.1g xanthan gum, 2g betaine, 0.03g hyaluronic acid, 1.2g trehalose, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 0.3g hexapeptide-1, 0.2g phenoxyethanol, and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding hexapeptide-1 and phenoxyethanol, uniformly stirring, sampling, inspecting, detecting, and filling to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Comparative example 4
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 0.05g disodium EDTA, 0.1g hydroxyethyl cellulose, 0.1g xanthan gum, 0.03g hyaluronic acid, 1.2g trehalose, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 0.3g hexapeptide-1, 1.5g hydrolyzed collagen, 0.1g dipotassium glycyrrhizinate, 0.2g phenoxyethanol and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, EDTA disodium, hydroxyethyl cellulose, xanthan gum, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding the polypeptide, the hydrolyzed collagen, the dipotassium glycyrrhizinate and the phenoxyethanol, uniformly stirring, sampling, inspecting, and filling after the detection is qualified to obtain the hexapeptide tightening essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
Comparative example 5
The hexapeptide tightening essence stock solution comprises the following raw materials in parts by weight: 2.5g propylene glycol, 2.5g butylene glycol, 0.05g disodium EDTA, 0.1g allantoin, 0.1g hydroxyethylcellulose, 0.1g xanthan gum, 2g betaine, 0.03g hyaluronic acid, 1.2g trehalose, 0.15g carbomer, 0.15g triethanolamine, 0.5g panthenol, 0.5g nicotinamide, 0.1g dipotassium glycyrrhizinate, 0.2g phenoxyethanol, and 88.02g water.
The preparation method comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, adding weighed water, heating to 85 ℃ while stirring, and stirring at constant temperature for 30min until no particles are dissolved;
step 2, starting cooling water to cool to 55 ℃, adding panthenol and nicotinamide, stirring and neutralizing until the mixture is completely transparent;
and 3, cooling to 35 ℃, adding dipotassium glycyrrhizinate and phenoxyethanol, uniformly stirring, sampling, inspecting, detecting, and filling to obtain the hexapeptide firming essence stock solution. Wherein, the packaging material is sterilized, can be filled after being detected to be qualified, and the finished product is inspected and qualified for detecting the microorganism.
The tightening essence stock solutions provided by the embodiment 5 and the comparative examples 1-5 are subjected to a facial skin tightening lifting and whitening wrinkle-removing test, and the test object is 600 women of 25-50 years old; the tightening essence stock solutions provided in example 5 and comparative examples 1-5 were used by 100 persons per group, respectively, by uniformly applying one coin in size stock solution to the face and around the canthus after cleaning the face every morning and evening, and gently patting until the essence stock solution is completely absorbed; the effects of use are shown in table 1.
Table 1 use effects of the tightening essences provided in example 5 and comparative examples 1 to 5
The experimental results show that: the embodiment 5 and the comparative examples 1 to 5 have certain moisturizing, whitening, tightening and wrinkle removing effects on facial skin, and the total effective rates can reach more than 77 percent respectively; however, in example 5, substances such as hexapeptide-1, hyaluronic acid, hydrolyzed collagen, panthenol, nicotinamide, dipotassium glycyrrhizinate, allantoin, propylene glycol, butylene glycol, betaine and the like are adopted and scientifically combined to obtain the hexapeptide tightening essence stock solution, the effect of the hexapeptide tightening essence stock solution is better than that of the tightening essence stock solution which lacks one or more substances in the proportion of 1-5, and the total effective rate of the hexapeptide tightening essence stock solution provided by the invention can reach 99%.
Therefore, the hexapeptide tightening essence stock solution provided by the invention contains substances capable of removing wrinkles and tightening the skin, such as hexapeptide, hyaluronic acid, hydrolyzed collagen and the like; adding skin conditioning agent such as panthenol, nicotinamide, dipotassium glycyrrhizinate and allantoin; the hexapeptide tightening essence stock solution is prepared by adding moisturizing substances such as propylene glycol, butanediol and betaine in a scientific compatibility manner, and has the effects of moisturizing, preserving heat, tightening skin, eliminating fine wrinkles, brightening skin and tightening skin. The effect is obviously reduced by lacking any raw materials, so that each raw material supplements each other and the lack of one is not enough. No allergic reaction occurred during the use period.
The present invention is not limited to the above-mentioned preferred embodiments, and any other products in various forms can be obtained by anyone in the light of the present invention, but any variations in the formulation or components thereof, which have the same or similar technical solutions as those of the present application, fall within the protection scope of the present invention.
Claims (3)
1. The tightening six-peptide essence is characterized in that: the composition is characterized by comprising the following raw materials in parts by weight: 1-5 parts of propylene glycol, 1-5 parts of butanediol, 0.01-0.1 part of EDTA disodium, 0.01-0.3 part of allantoin, 0.01-0.3 part of hydroxyethyl cellulose, 0.01-0.3 part of xanthan gum, 0.1-5 parts of betaine, 0.01-0.05 part of hyaluronic acid, 0.5-3 parts of trehalose, 0.05-0.3 part of carbomer, 0.05-0.3 part of triethanolamine, 0.1-1 part of panthenol, 0.1-1 part of nicotinamide, 0.1-1 part of hexapeptide, 0.5-3 part of hydrolyzed collagen, 0.01-0.5 part of dipotassium glycyrrhizinate, 0.05-1 part of phenoxyethanol and 80-100 parts of water;
the preparation method of the hexapeptide tightening essence comprises the following steps:
step 1, adding propylene glycol, butanediol, EDTA disodium, allantoin, hydroxyethyl cellulose, xanthan gum, betaine, hyaluronic acid, trehalose, carbomer and triethanolamine into a water phase pot, and adding water to obtain a first mixture;
step 2, adding panthenol and nicotinamide into the first mixture obtained in the step 1, stirring and neutralizing until the mixture is completely transparent to obtain a second mixture;
step 3, adding the hexapeptide, the hydrolyzed collagen, the dipotassium glycyrrhizinate and the phenoxyethanol into the second mixture obtained in the step 2, and uniformly stirring to obtain the hexapeptide tightening essence stock solution;
in the step 1, the obtained first mixture is heated to 80-90 ℃ while stirring, and is stirred for 20-40min at constant temperature until no particles are dissolved;
in the step 2, the first mixture obtained in the step 1 is cooled to 50-60 ℃, and then panthenol and nicotinamide are added;
in step 3, the second mixture obtained in step 2 is cooled to 30-40 ℃, and then the hexapeptide, the hydrolyzed collagen, the dipotassium glycyrrhizinate and the phenoxyethanol are added.
2. The hexapeptide tightening essence of claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 2-3 parts of propylene glycol, 2-3 parts of butanediol, 0.02-0.08 part of EDTA disodium, 0.05-0.2 part of allantoin, 0.05-0.2 part of hydroxyethyl cellulose, 0.05-0.2 part of xanthan gum, 1-3 parts of betaine, 0.02-0.04 part of hyaluronic acid, 1-2 parts of trehalose, 0.1-0.2 part of carbomer, 0.1-0.2 part of triethanolamine, 0.3-0.8 part of panthenol, 0.3-0.8 part of nicotinamide, 0.2-0.5 part of hexapeptide, 1-2 parts of hydrolyzed collagen, 0.05-0.3 part of dipotassium glycyrrhizinate, 0.1-0.5 part of phenoxyethanol and 85-90 parts of water.
3. The hexapeptide tightening essence of claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight: 2.5 parts of propylene glycol, 2.5 parts of butanediol, 0.05 part of EDTA disodium, 0.1 part of allantoin, 0.1 part of hydroxyethyl cellulose, 0.1 part of xanthan gum, 2 parts of betaine, 0.03 part of hyaluronic acid, 1.2 parts of trehalose, 0.15 part of carbomer, 0.15 part of triethanolamine, 0.5 part of panthenol, 0.5 part of nicotinamide, 0.3 part of hexapeptide, 1.5 parts of hydrolyzed collagen, 0.1 part of dipotassium glycyrrhizinate, 0.2 part of phenoxyethanol and 88.02 parts of water.
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| CN107468539A (en) * | 2017-08-14 | 2017-12-15 | 北京明弘科贸有限责任公司 | One kind contains ascorbic sub- gel and preparation method and application |
| CN108578310A (en) * | 2018-03-27 | 2018-09-28 | 吴海林 | A kind of nano peptide answers face exquisiteness essence and preparation method thereof |
| CN108403469A (en) * | 2018-05-29 | 2018-08-17 | 北京原肽干细胞医学研究院有限公司 | A kind of composition, preparation method and its purposes in cosmetics |
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| CN111297753A (en) * | 2019-12-26 | 2020-06-19 | 济南霜叶红生物科技有限公司 | Anti-aging and weight-losing tightening essence |
| CN111012729A (en) * | 2020-01-13 | 2020-04-17 | 南京平港健康管理有限公司 | Hyaluronic acid anti-wrinkle stock solution |
| CN111407714A (en) * | 2020-04-15 | 2020-07-14 | 东阿阿胶股份有限公司 | Anti-allergy, relieving and moisturizing lotion and preparation method thereof |
| CN111956574A (en) * | 2020-08-25 | 2020-11-20 | 宁波黑白香氛科技有限公司 | Spray essence formula and production process |
| CN112386535A (en) * | 2020-11-18 | 2021-02-23 | 荣鼎(广东)生物科技有限公司 | Stock solution of epidermal active hexapeptide |
| CN112972335A (en) * | 2021-03-12 | 2021-06-18 | 段传利 | Whitening and firming essence care solution and preparation method thereof |
| CN113350212A (en) * | 2021-07-19 | 2021-09-07 | 广州新妆生物科技有限公司 | Natural brightening essence and preparation method thereof |
| CN114010518A (en) * | 2021-10-22 | 2022-02-08 | 广东润和生物科技有限公司 | Coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair and preparation method thereof |
| CN115337223A (en) * | 2022-07-21 | 2022-11-15 | 西安博鸿生物技术有限公司 | Anti-wrinkle composition and application thereof |
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