CN114010518A - Coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair and preparation method thereof - Google Patents
Coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair and preparation method thereof Download PDFInfo
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- CN114010518A CN114010518A CN202111231107.3A CN202111231107A CN114010518A CN 114010518 A CN114010518 A CN 114010518A CN 202111231107 A CN202111231107 A CN 202111231107A CN 114010518 A CN114010518 A CN 114010518A
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- coenzyme
- skin
- whitening
- moisturizing
- mass
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- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims abstract description 85
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 81
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- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000006210 lotion Substances 0.000 title claims description 16
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- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 17
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Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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Abstract
The invention relates to the technical field of skin care products, and particularly relates to coenzyme Q10 essence water for moisturizing, whitening and promoting repair and a preparation method thereof. The coenzyme Q10, the nicotinamide and the hexapeptide are used as main formulas, the coenzyme Q10 lost in vivo is supplemented, the nicotinamide has the function of whitening the skin, and the hexapeptide has the functions of helping the skin to recover smooth, preventing fine wrinkles from forming, resisting wrinkles and resisting aging; therefore, the essence water consisting of the coenzyme Q10, the nicotinamide and the hexapeptide has the effects of promoting the restoration of skin physiological damage, resisting wrinkles and resisting aging, and is suitable for skin health care of people with dry skin and middle-aged and elderly people. The essence disclosed by the invention can solve the problems of dark, yellow, rough and lusterless skin after staying up all night, has an obvious whitening and repairing function, and also has the functions of moisturizing and preventing dry skin.
Description
Technical Field
The invention relates to the technical field of skin care products, and particularly relates to coenzyme Q10 essence water for moisturizing, whitening and promoting repair and a preparation method thereof.
Background
The skin is the natural coat of human body and is generally divided into three major parts, namely epidermis, dermis and subcutaneous tissue from outside to inside, and the epidermis is further divided into a cuticle layer, a stratum lucidum layer, a stratum granulosum layer, a acanthosphere layer and a stratum basale layer. The stratum corneum, the outermost layer of the skin, plays an important role in the integrity of the skin barrier function. A sebum membrane is formed on the horny layer, and is a semitransparent milky membrane formed by emulsifying sebum, sweat and epidermal cell secretion, and free fatty acid, lactate, urea and uric acid in the sebum membrane are natural moisturizing factors and play a role in moisturizing the skin. The stratum corneum and sebaceous membrane prevent the loss of water from the skin. Under normal conditions, the water content of the stratum corneum should be about 10%, and below this level, the skin is lack of water; skin dryness, which is a phenomenon that people feel uncomfortable, occurs when the skin lacks moisture. The symptoms mainly include tight skin, dry and desquamation of individual parts, and itching of the whole body after bathing. The important reasons for dry skin include aging, climate change, sleep deficiency, fatigue, overheating bath water, strong alkalinity of washing products, etc. The main causes of xerosis cutis are impaired keratinocyte proliferation and differentiation, reduced lipid content and reduced hydration, mainly occurring in the epidermis layer, while the dermis layer and subcutaneous tissues are not affected. Skin dryness is mainly caused by alterations in the structure of the stratum corneum of the epidermis and by disturbances in the skin barrier function. The normal stratum corneum has a water content of 15% to 20%, and when the water content in the stratum corneum falls below 10%, the skin becomes rough, causing skin discomfort and a dry appearance.
The intact epidermal barrier, which is similar to the architectural "brick wall structure" and consists of two functional components, is important to maintain the integrity and moisture content of normal skin appearance: (1) a cellular protein matrix consisting of interconnected lamellar keratinocytes and the outermost keratinocytes (corresponding to bricks), (2) intercellular lipids (corresponding to stucco). Maintaining and ensuring proper functioning of the two components, ensuring skin integrity, water balance, hydration and exfoliation of aged keratin. Damage to either component of the epidermis leads to increased transepidermal water loss, leading to xeroderma, manifesting as dry skin, desquamation, roughness, fine fissures, and itching, with normal stratum corneum water content of 20% to 35% and below 10% with marked xeroderma. The keratinocyte and natural moisturizing factor are used, the keratinocyte is constantly and regularly renewed, and can penetrate through all layers from the lowest layer to be finally shed, when the moisture is sufficient, the undegraded desmosomes are stripped, and the keratinocyte on the surface is separated and shed. Unlike normal skin, dry skin exhibits retention of keratinocyte desmosomes in the normally exfoliated stratum corneum, resulting in a rapid exfoliation of thin flakes or scale-like keratinocytes that can be visibly seen, which is not detectable in single cell exfoliation. The function of the epidermal barrier is damaged, the body has an automatic repair function, the repair function is called as the physiological repair of the epidermal barrier, if a self-balance signal connected with the function of repairing the epidermal barrier is started, the self-repair action of the epidermal barrier can be started through the synthesis of grease, the recovery process is long, and the damage degree, the age of a patient and the overall health condition of the patient need to be seen.
Therefore, it is very desirable to develop a skin care product having moisturizing, whitening and repair-promoting effects.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair comprises the following raw materials in parts by weight:
coenzyme Q10 is a fat-soluble component synthesized in vivo, which plays a crucial role in cellular energy production, and in the skin, coenzyme Q10 is present not only in living cells but also in skin surface lipids, which are part of the stratum corneum, forming the outermost barrier of the skin. Skin surface lipids consist of a mixture of sebum secreted by sebaceous glands and lipids mainly derived from keratinocytes. Because of their location on the skin surface, skin surface lipids are often exposed to ultraviolet radiation, air pollution, chemical oxidants and microbial contamination. Studies have shown that skin surface lipid coenzyme Q10 levels decrease with age and also after in vitro uv irradiation. The structural changes of the stratum corneum are the main cause of skin dryness, and the main components of the stratum corneum are structural proteins, intercellular lipids, natural moisturizing factors and enzyme systems. The barrier function of the skin and the hydration of the stratum corneum are largely dependent on the levels of lipids and natural moisturizing factors in the stratum corneum. Research shows that after the skin is treated by the external liniment containing the coenzyme Q10, the content of the coenzyme Q10 in skin surface lipid is obviously improved, and the content of the coenzyme Q10 in the skin surface lipid cannot be improved by taking a large amount of the coenzyme Q10 orally. This demonstrates that coenzyme Q10 supplementation by external preparations can directly counteract the short-term environmental stress-induced and age-related coenzyme Q10 deficiency on the skin surface. In particular, young people with normal coenzyme Q10 values may benefit because spontaneously occurring external oxidative stress may be neutralized rapidly by coenzyme Q10. Coenzyme Q10 supplementation is also a significant benefit in the elderly population where skin is already aging. Therefore, it is advantageous to use a coenzyme Q10 containing formulation to protect the outermost skin layer for any age of skin. Studies on coenzyme Q10 also indicate that topically applied Q10 on the skin can penetrate the skin, be metabolically converted, exert an antioxidant effect and can maintain cellular energy levels. These effects are not only beneficial to the elderly suffering from Q10 deficiency, but also may supplement the Q10 levels that are lost over time. People of all ages can be treated with the formula containing Q10 on a regular basis to more effectively combat short-term damage due to uv radiation and stress, and to promote long-term anti-aging effects on the skin.
Niacinamide, also known as VB3, is an important member of the vitamin family. History of studies on nicotinamide: the first discovery by Girish Parsad Mathur et al, uk, as early as 1974: 1-5% of nicotinic acid and 1-4% of sunscreen are compounded into a cream system, so that the effect of whitening skin is achieved. The action mechanism is as follows: nicotinic acid activates cyclic 3,5 nucleotide phosphodiesterase, which cleaves 3, 5-cyclic adenosine, which stimulates melanocyte hormone, to adenine-5-monophosphate, thereby reducing melanin production. The whitening efficacy of niacinamide is consistently recognized by authorities in the dermatology community. The whitening mechanism of niacinamide mainly comprises the following aspects: the metabolism is accelerated, and the exfoliation of melanocytes containing melanin is promoted. Skin cells require sufficient energy to perform daily physiological functions such as: the production of new cells, the synthesis of collagen, the production of fats and proteins, the synthesis of DNA, etc. Aging often causes the decline of cell activity energy, which results in slow cell renewal, hyperpigmentation, decreased skin hydration, uneven cutin, etc. Nicotinamide is directly taken up by the cells due to its small size. Nicotinamide can keep skin energy balance, recover cell energy, and accelerate collagen synthesis, thereby avoiding melanin hyperpigmentation caused by low oil content and thin cuticle of skin. Moreover, niacinamide promotes the exfoliation of melanin-containing keratinocytes by accelerating skin turnover. And (II) the melanin produced is acted on, and the transfer of the melanin to the surface layer cells is reduced. Since only melanin is transferred to keratinocytes, the skin appears dark. Nicotinamide acts on the produced melanin and effectively inhibits the transfer of about 35-40% of the melanin from melanocytes to keratinocytes, thereby reducing excessive pigmentation. Clinical tests prove that the area and the number of brown spots on the skin can be obviously reduced by using the moisturizer containing the nicotinamide, and the lightening of the color of the spots can be distinguished by naked eyes. This is the most important reason for niacinamide as whitening. And (III) the synthesis of epidermal layer proteins is promoted, and the skin texture is improved. Nicotinamide can promote the synthesis of epidermal protein, enhance the self defense capability of skin and increase the moisture content of skin. Thus, niacinamide is also widely used in anti-aging products.
The peptide belongs to degraded micromolecular collagen and contains amino acid groups; peptide is also a component originally existing in human body, two amino acids are called as two-peptide, three amino acids are called as three-peptide, and so on. The hexapeptide is an oligopeptide chain consisting of six amino acid groups. The hexapeptide is also called hexapeptide (Areginine Essence) and is extracted from a strain called unicellular green dense bacterium which is found in the south Pole gulf ice river mud at the earliest time, and the hexapeptide fine structure can effectively relieve and inhibit the forehead raising line, the contraction and the activity of the eye fishtail line and the peripheral muscles help the muscles relax, so that the peptide tissue recovers a smooth line. The plant hexapeptide is extracted from natural herbaceous plant and cut by selective enzyme, and possesses all the characteristics of hexapeptide. Meanwhile, the plant hexapeptide also has good water solubility and safety, so the plant hexapeptide is also called green peptide. The hexapeptide can promote the growth of collagen cells and fibroblasts, and has the functions of resisting wrinkles and aging; can inhibit nerve conduction, avoid muscle over contraction, and prevent fine lines; can relax muscle, effectively recombine collagen elasticity, and restore skin smoothness. The skin care effects of the peptides are firstly to prevent aging and wrinkle, wherein the five peptides and the six peptides are most known, the former can inhibit metal protein decomposition enzyme and stimulate collagen regeneration, and the latter is also called botulinum toxin and can block the conduction between nerves and muscles and relax over-active muscles so as to achieve the effects of smoothing surface fine lines and wrinkles such as dynamic lines and expression lines, and the other combined peptides respectively have the functions of activating hormone estrogen, improving sagging breasts, resisting eye bags and the like.
Compared with the prior art, the essence lotion provided by the invention adopts coenzyme Q10, nicotinamide and hexapeptide as main formulas, supplements coenzyme Q10 lost in vivo, and the nicotinamide has the function of whitening skin, and the hexapeptide has the functions of helping the skin to recover smooth, preventing fine wrinkles, resisting wrinkles and resisting aging; therefore, the essence water consisting of the coenzyme Q10, the nicotinamide and the hexapeptide has the effects of promoting the restoration of skin physiological damage, resisting wrinkles and resisting aging, and is suitable for skin health care of people with dry skin and middle-aged and elderly people. In addition, by adding various substances such as ceramide, 3-O-ethyl ascorbic acid, dipotassium glycyrrhizinate, D-panthenol, magnesium gluconate, 1, 2-pentanediol, caprylyl hydroximic acid, p-hydroxyacetophenone and the like, the skin physiological repair, wrinkle resistance and anti-aging effects can be further promoted, and the long-acting moisturizing and whitening effects can be achieved on the skin. The essence disclosed by the invention can solve the problems of dark, yellow, rough and lusterless skin after staying up all night, has an obvious whitening and repairing function, and also has the functions of moisturizing and preventing dry skin.
The material also comprises the following raw materials in parts by weight:
0.2-2 parts of dipotassium glycyrrhizinate
1-5 parts of D-panthenol.
The material also comprises the following raw materials in parts by weight:
vitamin B61-5 parts
0.05-0.2 part of disodium ethylene diamine tetraacetate.
The material also comprises the following raw materials in parts by weight:
1-5 parts of betaine.
The material also comprises the following raw materials in parts by weight:
allantoin 0.05-0.2 part
0.1-0.5 part of PCA sodium.
The material also comprises the following raw materials in parts by weight:
0.05-0.3 part of sodium hyaluronate.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid and magnesium gluconate into a proper amount of water, and mixing uniformly for later use;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to obtain the coenzyme Q10 essence water for moisturizing, whitening and promoting repair.
Further preferably, the feed additive is prepared from the following raw materials in parts by weight:
the preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid, p-hydroxyacetophenone and sodium hyaluronate in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, vitamin B6, disodium edetate, betaine, allantoin and sodium PCA into appropriate amount of water, and mixing;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to obtain the coenzyme Q10 essence water for moisturizing, whitening and promoting repair.
The invention has the beneficial effects that: compared with the prior art, the essence lotion provided by the invention adopts coenzyme Q10, nicotinamide and hexapeptide as main formulas, supplements coenzyme Q10 lost in vivo, and the nicotinamide has the function of whitening skin, and the hexapeptide has the functions of helping the skin to recover smooth, preventing fine wrinkles, resisting wrinkles and resisting aging; therefore, the essence water consisting of the coenzyme Q10, the nicotinamide and the hexapeptide has the effects of promoting the restoration of skin physiological damage, resisting wrinkles and resisting aging, and is suitable for skin health care of people with dry skin and middle-aged and elderly people. In addition, by adding various substances such as ceramide, 3-O-ethyl ascorbic acid, dipotassium glycyrrhizinate, D-panthenol, magnesium gluconate, 1, 2-pentanediol, caprylyl hydroximic acid, p-hydroxyacetophenone and the like, the skin physiological repair, wrinkle resistance and anti-aging effects can be further promoted, and the long-acting moisturizing and whitening effects can be achieved on the skin. The essence disclosed by the invention can solve the problems of dark, yellow, rough and lusterless skin after staying up all night, has an obvious whitening and repairing function, and also has the functions of moisturizing and preventing dry skin. .
Detailed Description
The present invention will be further described with reference to the following examples for facilitating understanding of those skilled in the art, and the description of the embodiments is not intended to limit the present invention.
Example 1
A coenzyme Q10 essence lotion comprises coenzyme Q10, nicotinamide, hexapeptide, ceramide, magnesium gluconate, 1, 2-pentanediol, octanoyl hydroximic acid, p-hydroxyacetophenone and water, and also comprises 3-O-ethyl ascorbic acid; wherein, the mass of the coenzyme Q10 is 3g, the mass of the nicotinamide is 3g, the mass of the hexapeptide is 1g, the mass of the ceramide is 3g, and the mass of the magnesium gluconate is 0.1g, calculated by 100g mass parts; the mass of the 1, 2-pentanediol is 3 g; the mass of the octanoyl hydroximic acid is 0.2 g; the mass of the p-hydroxyacetophenone is 0.15g, the mass of the 3-O-ethyl ascorbic acid is 0.5g, the balance is water, and the mass of the water is 86.05 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid and magnesium gluconate into 50g of water, and mixing uniformly for later use;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 2
This example differs from example 1 in that:
the essence water of the embodiment also comprises dipotassium glycyrrhizinate and D-panthenol, wherein the weight of the dipotassium glycyrrhizinate is 0.5g, the weight of the D-panthenol is 3g, and the weight of the water is adjusted to 82.55 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, dipotassium glycyrrhizinate and D-panthenol into 50g of water, and mixing;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 3
This example differs from example 1 in that:
the mass of the coenzyme Q10 in the embodiment is 1 g; the mass of nicotinamide is 1 g; the mass of the hexapeptide was 0.5g, and the mass of the water was adjusted to 90.55 g.
Example 4
This example differs from example 2 in that:
the mass of the coenzyme Q10 in the embodiment is 1 g; the mass of nicotinamide is 1 g; the mass of the hexapeptide was 0.5g, and the mass of the water was adjusted to 87.05 g.
Example 5
This example differs from example 1 in that:
the mass of the coenzyme Q10 in the embodiment is 5 g; the mass of nicotinamide is 5 g; the mass of the hexapeptide was 3g, and the mass of the water was adjusted to 80.05 g.
Example 6
This example differs from example 2 in that:
the mass of the coenzyme Q10 in the embodiment is 5 g; the mass of nicotinamide is 5 g; the mass of the hexapeptide was 3g, and the mass of the water was adjusted to 76.55 g.
Example 7
This example differs from example 2 in that:
the essence water of the embodiment also comprises vitamin B6 and disodium ethylene diamine tetraacetate. Wherein the mass of the vitamin B6 is 3g, the mass of the ethylene diamine tetraacetic acid is 0.1g, and the mass of the water is adjusted to 79.45 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, dipotassium glycyrrhizinate, D-panthenol, vitamin B6 and disodium ethylene diamine tetraacetate into 50g of water, and mixing uniformly for later use;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 8
This example differs from example 7 in that:
the serum of this example also included betaine. Wherein the weight of betaine was 3g, and the weight of water was adjusted to 76.45 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, dipotassium glycyrrhizinate, D-panthenol, vitamin B6, disodium ethylene diamine tetraacetate and betaine into 50g of water, and mixing uniformly for later use;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 9
This example differs from example 8 in that:
the serum of this example also included allantoin and sodium PCA. Wherein the mass of allantoin was 0.1g, the mass of sodium PCA was 0.3g, and the mass of water was adjusted to 76.05 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, dipotassium glycyrrhizinate, D-panthenol, vitamin B6, disodium edetate, betaine, allantoin and PCA sodium into 50g of water, and mixing;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 10
This example differs from example 9 in that:
the serum of this example also included sodium hyaluronate. The mass of sodium hyaluronate was 0.1g, and the mass of water was 75.95 g.
The preparation method of the coenzyme Q10 essence water for moisturizing, whitening and promoting repair comprises the following steps:
s1, dissolving sodium hyaluronate, caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid, magnesium gluconate, dipotassium glycyrrhizinate, D-panthenol, vitamin B6, disodium edetate, betaine, allantoin and PCA sodium into 50g of water, and mixing;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to make the total mass of the substances be 100g, so that the coenzyme Q10 essence water for moisturizing, whitening and promoting repair is prepared.
Example 11
The present embodiment differs from embodiment 10 in that:
the mass of the coenzyme Q10 in the embodiment is 1 g; the mass of nicotinamide is 1 g; the mass of the hexapeptide was 0.5g, and the mass of the water was adjusted to 80.45 g.
Example 12
The present embodiment differs from embodiment 10 in that:
the mass of the coenzyme Q10 in the embodiment is 5 g; the mass of nicotinamide is 5 g; the mass of the hexapeptide was 3g, and the mass of the water was adjusted to 69.95 g.
Example 13
The difference between the present embodiment and embodiment 11 is the mass of each substance, and the mass of each substance in the present embodiment is: the mass of the ceramide is 1g and the mass of the magnesium gluconate is 0.05g in 100g parts by mass; the mass of the 1, 2-pentanediol is 1 g; the mass of the octanoyl hydroximic acid is 0.1 g; the mass of the p-hydroxyacetophenone is 0.05 g; the mass of the 3-O-ethyl ascorbic acid is 0.2 g; the mass of the dipotassium glycyrrhizinate is 0.2 g; the mass of D-panthenol is 1 g; the mass of the vitamin B6 is 1 g; the weight of the disodium ethylene diamine tetraacetate is 0.05 g; the mass of the betaine is 1 g; the mass of the allantoin is 0.05 g; the mass of the PCA sodium is 0.1 g; the mass of the sodium hyaluronate is 0.05 g; the mass of water was 91.65 g.
Example 14
The difference between the present embodiment and embodiment 12 is the mass of each substance, and the mass of each substance in the present embodiment is: the mass of the ceramide is 5g and the mass of the magnesium gluconate is 0.2g in 100g parts by mass; the mass of the 1, 2-pentanediol is 3 g; the mass of the octanoyl hydroximic acid is 0.3 g; the mass of the p-hydroxyacetophenone is 0.3 g; the mass of the 3-O-ethyl ascorbic acid is 1 g; the mass of the dipotassium glycyrrhizinate is 2 g; the mass of D-panthenol is 5 g; the mass of the vitamin B6 is 5 g; the weight of the ethylene diamine tetraacetic acid disodium is 0.2 g; the mass of the betaine is 5 g; the mass of allantoin is 0.2 g; the mass of the PCA sodium is 0.5 g; the mass of the sodium hyaluronate is 0.3 g; the mass of water was 59 g.
Comparative example 1
This comparative example differs from example 10 in that:
the mass of the present comparative example coenzyme Q10 was 0 g; the mass of nicotinamide is 5 g; the mass of the hexapeptide is 2 g.
Comparative example 2
This comparative example differs from example 10 in that:
the mass of this comparative example coenzyme Q10 was 5 g; the mass of the nicotinamide is 0 g; the mass of the hexapeptide is 2 g.
Comparative example 3
This comparative example differs from example 10 in that:
the mass of this comparative example coenzyme Q10 was 7 g; the mass of the nicotinamide is 0 g; the mass of the hexapeptide is 0 g.
Comparative example 4
This comparative example differs from example 10 in that:
the mass of the present comparative example coenzyme Q10 was 0 g; the mass of the nicotinamide is 0 g; the mass of the hexapeptide was 0g, and the mass of the water was adjusted to 82.95 g.
The essence water prepared in examples 1 to 14 and comparative examples 1 to 4 was used for moisture retention and anti-wrinkle and anti-aging tests.
Wherein, the moisture retention experimental data is the experimental data detected by an Antsci-skin-sp skin tester, 14 subjects are found, and women with the age of 25-35 years are all found. Prior to the test subjects required the arm to be cleaned on the flexor side with a uniform mild cleanser and drawn 5X 5cm on the left arm2In a square experimental area of the size, 0.05g of the essence water of examples 1 to 14 and comparative examples 1 to 4 was applied to the experimental part of the subject, and the subject examined each experimental part with an Antsci-skin-sp skin tester every 20min in a constant environment and repeated 5 times, respectively, to obtain an average value, and the experimental results are as follows:
the anti-wrinkle and anti-aging experimental data are sensory experimental data of a user and are divided into 1-10 grades, the higher the grade number is, the more obvious the improvement effect is, the grade 1 is no improvement, the grade 2-3 is not obvious in improvement, and the grade 4-6 is general in improvement; 7-8, the improvement is good; 9-10 of the composition is improved obviously. The results of the experiment are as follows:
from the above experimental results, it can be seen that the effect of the essence containing coenzyme Q10, nicotinamide and hexapeptide is more excellent than that of the essence containing only one or two of the coenzyme Q10, nicotinamide and hexapeptide, which is mainly the result of the combined action of coenzyme Q10, nicotinamide and hexapeptide. Wherein, the nicotinamide can reduce the water loss of the skin when being externally used, reduce the secretion of sebum and enhance the barrier function of the skin; meanwhile, the cohesiveness and the thickness of the stratum corneum can be increased, and the maturity of the stratum corneum is increased. The nicotinamide and coenzyme Q10 are applied together, so that the skin water retention effect is stronger. Nicotinamide also has a pigmentation-reducing effect, which is associated with the inhibition of melanosome transfer from melanocytes to keratinocytes, and at the same time, nicotinamide also inhibits the expression of melanin, one of the important pathways for the inhibition of melanin synthesis is its effect on the transport of substances in melanocytes, nicotinamide has a regulatory effect on calcium pumps, the expression of the cellular motor protein Dynein and the movement of melanosomes in melanocytes, and a certain concentration of nicotinamide accelerates the movement rate of melanosomes in melanocytes. In addition, nicotinamide also has anti-inflammatory effect, and can inhibit a series of proinflammatory factors, such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha), interleukin-1 beta (IL-1 beta), interleukin-8 (IL-8) and the like. Meanwhile, nicotinamide can reduce the activity of desquamation enzyme, reduce the activity of trypsin-like enzyme and fibrinolysin which affect inflammation, and reduce the infiltration of mononuclear cells and phagocyte. Nicotinamide also inhibits prostaglandin E2(PGE2) and reduces the production of Nitric Oxide (NO) and Reactive Oxygen Species (ROS). However, in an in vitro cell experiment, nicotinamide was found not to affect the secretion of interleukin-8 (IL-8) by Keratinocytes (KC). When the cell is irradiated by ultraviolet, the cell self-repair function can be stimulated, a large amount of Adenosine Triphosphate (ATP) is consumed in the process, tests prove that nicotinamide can reduce the consumption of ATP in the cell and provide energy for cell repair, and meanwhile, nicotinamide is a component of coenzyme I (NAD) and coenzyme II (NADP) and can influence the normal respiration and metabolism of the cell.
The invention combines coenzyme Q10, nicotinamide and hexapeptide for use, greatly improves the effect of any one of the coenzyme Q10, the nicotinamide and the hexapeptide when used alone, and obtains the essence lotion which can keep moisture for a long time and has the effects of resisting wrinkles and resisting aging. And 3-O-ethyl ascorbic acid, ceramide, dipotassium glycyrrhizinate, betaine, magnesium gluconate, disodium ethylene diamine tetraacetate, D-panthenol, vitamin B6, caprylyl hydroximic acid and other substances are added, and the added parts by mass are controlled to prepare the essence water which has good moisturizing and whitening effects on the skin and can promote the physiological repair of the skin. The added vitamin B6 is an indispensable substance for human bodies, participates in various metabolic reactions, is used in combination with other substances of the invention, and can accelerate the absorption of the skin while helping the metabolism of the skin; the disodium ethylene diamine tetraacetate has the effect of oxidation resistance, so that the oxidation resistance of the skin can be further enhanced, and the anti-aging capability is improved; and the caprylyl hydroximic acid has the effects of resisting and inhibiting bacteria, so that the long-term use of the essence water is ensured without destroying the activity of substances in the essence water. In addition, the allantoin, the PCA sodium and the sodium hyaluronate are added in a certain amount, so that the effects of wrinkle resistance and aging resistance of the essence are further enhanced.
According to the invention, by controlling the substances added with the essence water and the related proportion, the essence water has long-acting skin moisturizing and whitening effects on dry skin, and can particularly improve the problems of dark, yellow, rough, dull and the like of the skin after staying up all night; meanwhile, the skin physiological state can be repaired, and the wrinkled skin can be helped to recover the youthful and beautiful appearance.
The above-described embodiments are preferred implementations of the present invention, and the present invention may be implemented in other ways without departing from the spirit of the present invention.
Claims (8)
1. The coenzyme Q10 essence lotion capable of moisturizing, whitening and promoting repair is characterized in that: the feed comprises the following raw materials in parts by weight:
2. the coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the composite material comprises the following raw materials in parts by weight:
0.2-2 parts of dipotassium glycyrrhizinate
1-5 parts of D-panthenol.
3. The coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the material also comprises the following raw materials in parts by weight:
vitamin B61-5 parts
0.05-0.2 part of disodium ethylene diamine tetraacetate.
4. The coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the material also comprises the following raw materials in parts by weight:
1-5 parts of betaine.
5. The coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the feed also comprises the following raw materials in parts by weight:
allantoin 0.05-0.2 part
0.1-0.5 part of PCA sodium.
6. The coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the feed also comprises the following raw materials in parts by weight:
0.05-0.3 part of sodium hyaluronate.
7. The coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in claim 1, wherein: the composition is characterized by comprising the following raw materials in parts by weight:
8. the preparation method of the coenzyme Q10 essence lotion for moisturizing, whitening and promoting repair as claimed in any one of claims 1 to 7, is characterized in that: the method comprises the following steps:
s1, dissolving caprylyl hydroximic acid and p-hydroxyacetophenone in 1, 2-pentanediol for later use;
s2, adding nicotinamide, hexapeptide, 3-O-ethyl ascorbic acid and magnesium gluconate into a proper amount of water, and mixing uniformly for later use;
s3, uniformly mixing coenzyme Q10 and the substances in the step S2, then adding the substances in the step S1, mixing and dissolving the substances until the substances are in a particle-free state, and adding the balance of water to obtain the coenzyme Q10 essence water for moisturizing, whitening and promoting repair.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115337223A (en) * | 2022-07-21 | 2022-11-15 | 西安博鸿生物技术有限公司 | Anti-wrinkle composition and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840375A (en) * | 2015-04-11 | 2015-08-19 | 广东医学院 | A group of coenzyme Q10 masks with effects of spot removing, wrinkle preventing and whitening |
| CN106963661A (en) * | 2017-04-10 | 2017-07-21 | 深圳科婷科技有限公司 | Argireline compacts elite stoste and preparation method thereof |
| CN110215407A (en) * | 2018-09-26 | 2019-09-10 | 嫦娥创新（武汉）生物科技有限公司 | A kind of anti-ageing compact composition and its cosmetics and application |
-
2021
- 2021-10-22 CN CN202111231107.3A patent/CN114010518A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840375A (en) * | 2015-04-11 | 2015-08-19 | 广东医学院 | A group of coenzyme Q10 masks with effects of spot removing, wrinkle preventing and whitening |
| CN106963661A (en) * | 2017-04-10 | 2017-07-21 | 深圳科婷科技有限公司 | Argireline compacts elite stoste and preparation method thereof |
| CN110215407A (en) * | 2018-09-26 | 2019-09-10 | 嫦娥创新（武汉）生物科技有限公司 | A kind of anti-ageing compact composition and its cosmetics and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115337223A (en) * | 2022-07-21 | 2022-11-15 | 西安博鸿生物技术有限公司 | Anti-wrinkle composition and application thereof |
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