CN1069311C - 2-羟基-4-甲硫基丁酸(mha)的制备方法 - Google Patents

2-羟基-4-甲硫基丁酸(mha)的制备方法 Download PDF

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Publication number
CN1069311C
CN1069311C CN95194582A CN95194582A CN1069311C CN 1069311 C CN1069311 C CN 1069311C CN 95194582 A CN95194582 A CN 95194582A CN 95194582 A CN95194582 A CN 95194582A CN 1069311 C CN1069311 C CN 1069311C
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CN
China
Prior art keywords
mha
acid
water
hydroxy
sulfuric acid
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Expired - Fee Related
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CN95194582A
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English (en)
Chinese (zh)
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CN1155277A (zh
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赫尔穆特·祖赫斯兰
福尔克尔·海夫纳
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Evonik Operations GmbH
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Degussa GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
CN95194582A 1994-08-12 1995-08-02 2-羟基-4-甲硫基丁酸(mha)的制备方法 Expired - Fee Related CN1069311C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4428608.2 1994-08-12
DE4428608A DE4428608C1 (de) 1994-08-12 1994-08-12 Verfahren zur Gewinnung von 2-Hydroxy-4-methylthiobuttersäure (MHA)

Publications (2)

Publication Number Publication Date
CN1155277A CN1155277A (zh) 1997-07-23
CN1069311C true CN1069311C (zh) 2001-08-08

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ID=6525551

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95194582A Expired - Fee Related CN1069311C (zh) 1994-08-12 1995-08-02 2-羟基-4-甲硫基丁酸(mha)的制备方法

Country Status (10)

Country Link
US (1) US5847207A (cg-RX-API-DMAC7.html)
EP (1) EP0775109B1 (cg-RX-API-DMAC7.html)
JP (1) JP3847337B2 (cg-RX-API-DMAC7.html)
CN (1) CN1069311C (cg-RX-API-DMAC7.html)
AU (1) AU3255795A (cg-RX-API-DMAC7.html)
DE (2) DE4428608C1 (cg-RX-API-DMAC7.html)
ES (1) ES2132700T3 (cg-RX-API-DMAC7.html)
MY (1) MY132083A (cg-RX-API-DMAC7.html)
TW (1) TW280811B (cg-RX-API-DMAC7.html)
WO (1) WO1996005173A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103467348A (zh) * 2013-10-08 2013-12-25 重庆紫光化工股份有限公司 大颗粒晶型高堆积密度2-羟基-4-甲硫基丁酸钙的制备方法
CN103497131A (zh) * 2013-10-08 2014-01-08 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT832062E (pt) 1995-06-07 2002-03-28 Novus Int Inc Processo de hidrolise continuo para preparacao de acido 2-hidroxi-4-metiltiobutanoico ou seus sais
DE19548538C2 (de) * 1995-12-23 1997-12-18 Degussa Verfahren zur Gewinnung von 2-Hydroxy-4-methylthiobuttersäure (MHA)
DE19654485A1 (de) * 1996-12-27 1998-07-02 Degussa Verfahren zur Gewinnung von lagerstabiler 2-Hydroxy-4-methylthiobuttersäure (MHA)
DE19754562A1 (de) * 1997-12-09 1999-06-10 Degussa Verfahren zur Rückgewinnung von Schwefelsäure aus schwefelhaltigen Nebenprodukten eines Prozesses zur Herstellung von 2-Hydroxy-4-methylthiobuttersäure (MHA)
FR2780968B1 (fr) * 1998-07-10 2000-08-18 Rhone Poulenc Nutrition Animal Procede de preparation de l'acide hydroxymethylthiobutyrique
JP4517486B2 (ja) * 2000-09-25 2010-08-04 住友化学株式会社 ２−ヒドロキシ−４−メチルチオブタンニトリルの製造方法
JP4517491B2 (ja) * 2000-10-11 2010-08-04 住友化学株式会社 ２−ヒドロキシ−４−メチルチオブタン酸の製造方法
JP4517520B2 (ja) * 2001-02-27 2010-08-04 住友化学株式会社 ２−ヒドロキシ−４−メチルチオブタン酸の製造方法
US20060151493A1 (en) * 2002-12-18 2006-07-13 Biotage Ab Method and apparatus for control of chemical reactions
JP4696496B2 (ja) * 2004-08-18 2011-06-08 住友化学株式会社 ２−ヒドロキシ−４−メチルチオ酪酸の製造方法
FR2919607B1 (fr) * 2007-07-31 2012-10-12 Adisseo Ireland Ltd Procede pour la conversion catalytique de 2-hydroxy-4- methylthiobutanenitrile (hmtbn) en 2-hydroxy-4- methylthiobutanamide (hmtbm).
MX340125B (es) * 2011-02-23 2016-06-28 Evonik Degussa Gmbh 2-hidroxi-4-(metiltio) butironitrilo estable en almacenamiento.
GB2499218A (en) 2012-02-08 2013-08-14 Rumenco Ltd Production of animal feed supplement using a thin film processor
US9540661B2 (en) 2012-07-09 2017-01-10 Basf Se Method for the complete anaerobic digestion of polymer mixtures
CN103420883A (zh) * 2013-08-28 2013-12-04 重庆紫光化工股份有限公司 利用粗氢氰酸气体制备2-羟基-4-甲硫基丁腈的方法
CN103664717A (zh) * 2013-11-19 2014-03-26 重庆紫光化工股份有限公司 廉价的环境友好的d,l-2-羟基-4-甲硫基丁酸的制备方法
EP3388523A1 (en) 2017-04-13 2018-10-17 Evonik Degussa GmbH Enzymatic method for producing 2-hydroxy-4-methylmercaptobutanoic acid (mha)
CN111116437B (zh) * 2018-11-01 2021-02-05 山东新和成氨基酸有限公司 制备2-羟基-4-甲硫基丁酸及其中间体的方法和装置
EP4299560A1 (en) 2022-07-01 2024-01-03 AMINO GmbH Method for the production of alpha hydroxy-alkylthio carboxylic acids and derivatives thereof
CN115894313B (zh) * 2022-11-29 2024-04-30 山东新和成氨基酸有限公司 一种2-羟基-4-甲硫基丁酸盐的制备方法及生产系统

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142488A2 (en) * 1983-11-14 1985-05-22 Monsanto Company Liquid 2-hydroxy-methylthiobutyric acid and process for the preparation thereof
CN85101575A (zh) * 1984-02-24 1987-01-10 孟山都公司 液态2-羟基-4-甲硫基丁酸的制备方法
EP0330527A1 (fr) * 1988-02-22 1989-08-30 Sociedad De Desarrollo Tecnico Industrial Procédé de préparation de solutions aqueuses de l'acide 2-hydroxy-4-méthylthio-butyrique

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA694650A (en) * 1964-09-22 Mark Victor Preparation of 4-(alkylthio)-2-hydroxybutyric acids
US2745745A (en) * 1952-10-30 1956-05-15 Monsanto Chemicals Poultry feed
US2938053A (en) * 1955-12-29 1960-05-24 Monsanto Chemicals Amino acid analogues
CH385823A (de) * 1959-09-01 1964-12-31 Inventa Ag Verfahren zur Herstellung des Calciumsalzes der a-Oxy-y-methylthio-buttersäure
BE611435A (fr) * 1960-12-14 1962-06-12 Stamicarbon Procédé de préparation de sels métalliques d'acide alpha-hydroxy- gamma -méthylmercaptobutyrique
US3773927A (en) * 1971-12-20 1973-11-20 Du Pont Preparation of an aqueous slurry of ammonium chloride and methylmercapto-hydroxybutyric acid
US4353924A (en) * 1979-09-04 1982-10-12 Monsanto Company Animal feed supplement having reduced corrosion characteristics
US4310690A (en) * 1980-10-08 1982-01-12 E. I. Du Pont De Nemours And Company Preparation of the calcium salt of α-hydroxy-gamma-methylmercaptobutyric acid
ATE28747T1 (de) * 1983-11-14 1987-08-15 Monsanto Co Verfahren zur herstellung von fluessiger 2hydroxymethylthiobuttersaeure.
MY109603A (en) * 1992-05-21 1997-03-31 Daicel Chem Process for producing 2-hydroxy-4-methylthiobutanoic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142488A2 (en) * 1983-11-14 1985-05-22 Monsanto Company Liquid 2-hydroxy-methylthiobutyric acid and process for the preparation thereof
CN85101575A (zh) * 1984-02-24 1987-01-10 孟山都公司 液态2-羟基-4-甲硫基丁酸的制备方法
EP0330527A1 (fr) * 1988-02-22 1989-08-30 Sociedad De Desarrollo Tecnico Industrial Procédé de préparation de solutions aqueuses de l'acide 2-hydroxy-4-méthylthio-butyrique

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103467348A (zh) * 2013-10-08 2013-12-25 重庆紫光化工股份有限公司 大颗粒晶型高堆积密度2-羟基-4-甲硫基丁酸钙的制备方法
CN103497131A (zh) * 2013-10-08 2014-01-08 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法
CN103497131B (zh) * 2013-10-08 2015-05-13 重庆紫光化工股份有限公司 2-羟基-4-甲硫基丁酸金属螯合物的制备方法
CN103467348B (zh) * 2013-10-08 2015-09-16 重庆紫光化工股份有限公司 大颗粒晶型高堆积密度2-羟基-4-甲硫基丁酸钙的制备方法

Also Published As

Publication number Publication date
TW280811B (cg-RX-API-DMAC7.html) 1996-07-11
MY132083A (en) 2007-09-28
CN1155277A (zh) 1997-07-23
JPH10504294A (ja) 1998-04-28
JP3847337B2 (ja) 2006-11-22
EP0775109A1 (de) 1997-05-28
EP0775109B1 (de) 1999-01-20
WO1996005173A1 (de) 1996-02-22
AU3255795A (en) 1996-03-07
US5847207A (en) 1998-12-08
ES2132700T3 (es) 1999-08-16
DE59504922D1 (de) 1999-03-04
DE4428608C1 (de) 1996-02-29

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Patentee before: Degussa-Yuls Co., Ltd.

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Granted publication date: 20010808

Termination date: 20090902