CN1069194C - 药物组合物的制备方法 - Google Patents
药物组合物的制备方法 Download PDFInfo
- Publication number
- CN1069194C CN1069194C CN91110545A CN91110545A CN1069194C CN 1069194 C CN1069194 C CN 1069194C CN 91110545 A CN91110545 A CN 91110545A CN 91110545 A CN91110545 A CN 91110545A CN 1069194 C CN1069194 C CN 1069194C
- Authority
- CN
- China
- Prior art keywords
- pharmaceutically acceptable
- oil
- hydrogen atom
- emulsifying agent
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
大鼠眼中的传送能力(ng/g(重量)) | 角膜视网膜脉络膜眼球晶体 | 192.9±48.52.6±1.8n.d. | 141.3±21.72.5 ±0.7n.d. | 762.8±60.626.2±3.21.9±0.7 |
Claims (9)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29813590 | 1990-11-02 | ||
JP298136/1990 | 1990-11-02 | ||
JP298135/90 | 1990-11-02 | ||
JP298136/90 | 1990-11-02 | ||
JP29813690 | 1990-11-02 | ||
JP298135/1990 | 1990-11-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1061153A CN1061153A (zh) | 1992-05-20 |
CN1069194C true CN1069194C (zh) | 2001-08-08 |
Family
ID=26561392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN91110545A Expired - Lifetime CN1069194C (zh) | 1990-11-02 | 1991-11-01 | 药物组合物的制备方法 |
Country Status (17)
Country | Link |
---|---|
US (1) | US5955469A (zh) |
EP (1) | EP0483842B1 (zh) |
JP (1) | JPH059117A (zh) |
KR (1) | KR100206722B1 (zh) |
CN (1) | CN1069194C (zh) |
AT (1) | ATE115400T1 (zh) |
AU (1) | AU655603B2 (zh) |
CA (1) | CA2054629C (zh) |
DE (1) | DE69105915T2 (zh) |
DK (1) | DK0483842T3 (zh) |
ES (1) | ES2064856T3 (zh) |
HU (1) | HU217540B (zh) |
IE (1) | IE66592B1 (zh) |
PH (1) | PH31204A (zh) |
PT (1) | PT99398B (zh) |
RU (1) | RU2084222C1 (zh) |
UA (1) | UA43820C2 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2149264T3 (es) * | 1993-03-22 | 2000-11-01 | Cognis Australia Pty Ltd | Agente terapeutico para el tratamiento de melanomas. |
ES2178651T3 (es) * | 1993-03-22 | 2003-01-01 | Cognis Australia Pty Ltd | Compuestos carotenoides terapeuticos deispersables en agua. |
DE4447972B4 (de) * | 1993-05-27 | 2007-12-27 | Novartis Ag | Galenische Formulierungen |
GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
GB2315216B (en) * | 1993-10-05 | 1998-10-14 | Ciba Geigy Ag | Microemulsion preconcentrates comprising FK506 or 33-epi-chloro-33-desoxy-ascomycin |
CN1089233C (zh) * | 1994-10-26 | 2002-08-21 | 诺瓦蒂斯有限公司 | 药物组合物 |
US6361760B1 (en) | 1995-09-19 | 2002-03-26 | Fujisawa Pharmaceutical Co., Ltd. | Aerosol compositions |
US6864232B1 (en) | 1998-12-24 | 2005-03-08 | Sucampo Ag | Agent for treating visual cell function disorder |
GB0108498D0 (en) * | 2001-04-04 | 2001-05-23 | Novartis Ag | Organic Compounds |
AR038628A1 (es) * | 2002-03-04 | 2005-01-19 | Novartis Ag | Composicion oftalmica |
JP2005230125A (ja) | 2004-02-17 | 2005-09-02 | Aruze Corp | ゲーム装置及びゲームプログラム |
KR100866728B1 (ko) * | 2004-11-12 | 2008-11-03 | 주식회사종근당 | 타크로리무스를 함유하는 주사제 |
CN101869547B (zh) | 2009-04-24 | 2012-02-22 | 张娜 | 一种他克莫司注射制剂 |
KR101230573B1 (ko) * | 2010-04-21 | 2013-02-06 | 닥터후 주식회사 | 천년초 추출물 또는 백년초 추출물을 함유하는 천연 유화제 및 이를 포함하는 화장품 조성물, 식품 조성물 및 의약 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
DK175235B1 (da) * | 1987-11-09 | 2004-07-19 | Novartis Ag | Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf |
AU630866B2 (en) * | 1987-12-09 | 1992-11-12 | Fisons Plc | Macrocyclic compounds |
EP0356399A3 (en) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them |
GB8925797D0 (en) * | 1989-11-15 | 1990-01-04 | Fisons Plc | Compositions |
US5260301A (en) * | 1990-03-01 | 1993-11-09 | Fujisawa Pharmaceutical Co., Ltd. | Pharmaceutical solution containing FK-506 |
-
1991
- 1991-10-29 PH PH43369A patent/PH31204A/en unknown
- 1991-10-31 HU HU438/91A patent/HU217540B/hu unknown
- 1991-10-31 EP EP91118592A patent/EP0483842B1/en not_active Expired - Lifetime
- 1991-10-31 AT AT91118592T patent/ATE115400T1/de not_active IP Right Cessation
- 1991-10-31 DK DK91118592.4T patent/DK0483842T3/da active
- 1991-10-31 DE DE69105915T patent/DE69105915T2/de not_active Expired - Lifetime
- 1991-10-31 PT PT99398A patent/PT99398B/pt not_active IP Right Cessation
- 1991-10-31 AU AU86922/91A patent/AU655603B2/en not_active Expired
- 1991-10-31 JP JP3313423A patent/JPH059117A/ja active Pending
- 1991-10-31 KR KR1019910019228A patent/KR100206722B1/ko not_active IP Right Cessation
- 1991-10-31 IE IE381391A patent/IE66592B1/en not_active IP Right Cessation
- 1991-10-31 ES ES91118592T patent/ES2064856T3/es not_active Expired - Lifetime
- 1991-10-31 CA CA002054629A patent/CA2054629C/en not_active Expired - Lifetime
- 1991-11-01 UA UA5010231A patent/UA43820C2/uk unknown
- 1991-11-01 CN CN91110545A patent/CN1069194C/zh not_active Expired - Lifetime
- 1991-11-01 RU SU5010231/14A patent/RU2084222C1/ru active
-
1994
- 1994-07-25 US US08/280,137 patent/US5955469A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HUT60924A (en) | 1992-11-30 |
DK0483842T3 (da) | 1995-02-20 |
CA2054629C (en) | 2002-04-16 |
RU2084222C1 (ru) | 1997-07-20 |
AU8692291A (en) | 1992-05-07 |
CA2054629A1 (en) | 1992-05-03 |
EP0483842B1 (en) | 1994-12-14 |
DE69105915T2 (de) | 1995-05-04 |
ATE115400T1 (de) | 1994-12-15 |
CN1061153A (zh) | 1992-05-20 |
IE913813A1 (en) | 1992-05-22 |
UA43820C2 (uk) | 2002-01-15 |
PT99398B (pt) | 1999-04-30 |
HU217540B (hu) | 2000-02-28 |
JPH059117A (ja) | 1993-01-19 |
AU655603B2 (en) | 1995-01-05 |
US5955469A (en) | 1999-09-21 |
KR920009400A (ko) | 1992-06-25 |
PH31204A (en) | 1998-05-05 |
PT99398A (pt) | 1992-09-30 |
ES2064856T3 (es) | 1995-02-01 |
DE69105915D1 (de) | 1995-01-26 |
KR100206722B1 (ko) | 1999-07-01 |
EP0483842A1 (en) | 1992-05-06 |
HU343891D0 (en) | 1992-01-28 |
IE66592B1 (en) | 1996-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
ASS | Succession or assignment of patent right |
Owner name: ASTELLAS PHARMA INC. Free format text: FORMER OWNER: FUJISAWA PHARMACEUTICAL CO., LTD. Effective date: 20060414 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20060414 Address after: Tokyo, Japan Patentee after: Yamanouchi Pharma Co., Ltd. Address before: Osaka City, Osaka of Japan Patentee before: Fujisawa Pharmaceutical Co., Ltd. |
|
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20111101 Granted publication date: 20010808 |