CN105764914B - 新型吸附性组合物及其用途 - Google Patents

新型吸附性组合物及其用途 Download PDF

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Publication number
CN105764914B
CN105764914B CN201480058100.8A CN201480058100A CN105764914B CN 105764914 B CN105764914 B CN 105764914B CN 201480058100 A CN201480058100 A CN 201480058100A CN 105764914 B CN105764914 B CN 105764914B
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Prior art keywords
microparticles
exchange resin
cell
marathon
biomolecules
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Expired - Fee Related
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CN201480058100.8A
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Chinese (zh)
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CN105764914A (zh
Inventor
R·哈恩
A·章格鲍尔
A·特列菲洛夫
M·艾曼德埃菲尔
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Boehringer Ingelheim RCV GmbH and Co KG
Sandoz AG
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Boehringer Ingelheim RCV GmbH and Co KG
Sandoz AG
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • B01J39/05—Processes using organic exchangers in the strongly acidic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • B01J39/07—Processes using organic exchangers in the weakly acidic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/16—Organic material
    • B01J39/18—Macromolecular compounds
    • B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • B01J41/05—Processes using organic exchangers in the strongly basic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • B01J41/07—Processes using organic exchangers in the weakly basic form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B01J41/14—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/02—Column or bed processes
    • B01J47/04—Mixed-bed processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480058100.8A 2013-08-23 2014-08-25 新型吸附性组合物及其用途 Expired - Fee Related CN105764914B (zh)

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Application Number Priority Date Filing Date Title
EP13181537 2013-08-23
EP13181540 2013-08-23
EP13181537.5 2013-08-23
EP13181540.9 2013-08-23
PCT/EP2014/068014 WO2015025062A1 (en) 2013-08-23 2014-08-25 Novel adsorbent composition and use thereof

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CN105764914A CN105764914A (zh) 2016-07-13
CN105764914B true CN105764914B (zh) 2020-12-25

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CN201480058100.8A Expired - Fee Related CN105764914B (zh) 2013-08-23 2014-08-25 新型吸附性组合物及其用途
CN201480058620.9A Expired - Fee Related CN105683210B (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒
CN202010556781.8A Pending CN111875665A (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒

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CN201480058620.9A Expired - Fee Related CN105683210B (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒
CN202010556781.8A Pending CN111875665A (zh) 2013-08-23 2014-08-25 用于细胞破碎和/或回收生物分子的微粒

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EP (2) EP3036249B1 (enExample)
JP (3) JP2016531128A (enExample)
KR (2) KR20160065092A (enExample)
CN (3) CN105764914B (enExample)
AU (2) AU2014310479B2 (enExample)
CA (2) CA2919288A1 (enExample)
SG (3) SG11201600574XA (enExample)
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CA2919288A1 (en) * 2013-08-23 2015-02-26 Boehringer Ingelheim Rcv Gmbh & Co Kg Microparticles for cell disruption and/or biomolecule recovery
US10626376B2 (en) * 2016-11-14 2020-04-21 St. Jude Children's Research Hospital Method for isolating and purifying adeno-associated virus particles using salt
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations
KR101964242B1 (ko) * 2017-04-26 2019-04-01 한국과학기술원 복합 구조체를 이용한 진단 시스템 및 방법
CN108342382B (zh) * 2018-01-30 2020-12-15 广东海大畜牧兽医研究院有限公司 一种核酸快速提取方法及其试剂盒
CN109402112A (zh) * 2018-11-08 2019-03-01 华中农业大学 一种快速、低成本从鸡血中分离pcr模板的方法
CN110221010B (zh) * 2019-04-29 2021-12-14 贵州茅台酒股份有限公司 一种测定酱香型白酒大曲中吡喃酮类化合物的方法
JP7544339B2 (ja) * 2020-09-03 2024-09-03 日機装株式会社 被処理液の再生方法、被処理液の再生剤および被処理液の再生装置
US20220194791A1 (en) * 2020-12-22 2022-06-23 Tokyo Ohka Kogyo Co., Ltd. Method for producing aqueous solution of purified orthoperiodic acid, method for producing semiconductor device, and aqueous solution of orthoperiodic acid
CN112979352A (zh) * 2021-03-08 2021-06-18 亚太建设科技信息研究院有限公司 一种回收尿液中磷酸盐的方法
CN113337452A (zh) * 2021-04-19 2021-09-03 中国医学科学院医学生物学研究所 一种利用高密度cho-s细胞无血清培养表达制备双因子抗体的方法
CN117241881A (zh) * 2021-06-10 2023-12-15 三菱化学株式会社 合成吸附剂、抗体的纯化方法和抗体的制造方法
CN113607903B (zh) * 2021-07-30 2024-03-15 振德医疗用品股份有限公司 一种检测含有正电荷聚合物细菌内毒素的方法
CN115245814B (zh) * 2021-12-06 2023-08-11 青岛大学 一种由固废制备的固定床用吸附剂及其制备方法
CN115404235B (zh) * 2022-09-16 2025-06-13 广东海天创新技术有限公司 酱醪中微生物总dna的提取方法
WO2024132899A1 (en) * 2022-12-21 2024-06-27 Climeworks Ag Uses of amino sorbents for capturing of co2 from gas streams
CN116287077A (zh) * 2023-03-13 2023-06-23 山东至善硒生物科技有限公司 一种硒多肽的提取方法
CN118458887A (zh) * 2024-05-09 2024-08-09 中国科学院水生生物研究所 一种饮用水厂强化混凝除藻的方法
CN120330138B (zh) * 2025-06-20 2025-08-29 上海沐医医学生物工程有限公司 一种msc的培养基添加剂及其应用

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EP3036249A1 (en) 2016-06-29
SG11201600275PA (en) 2016-02-26
WO2015025063A1 (en) 2015-02-26
SG11201600574XA (en) 2016-02-26
CA2919288A1 (en) 2015-02-26
AU2014310479B2 (en) 2020-01-30
US20190046969A1 (en) 2019-02-14
EP3036249B1 (en) 2019-03-13
CN105764914A (zh) 2016-07-13
KR20160065093A (ko) 2016-06-08
JP2016531128A (ja) 2016-10-06
JP2020019799A (ja) 2020-02-06
WO2015025062A1 (en) 2015-02-26
US10076749B2 (en) 2018-09-18
CN105683210B (zh) 2020-07-14
US10537887B2 (en) 2020-01-21
AU2014310479A1 (en) 2016-02-25
US20160193598A1 (en) 2016-07-07
EP3036250A1 (en) 2016-06-29
JP2016530271A (ja) 2016-09-29
AU2014310480A1 (en) 2016-02-25
AU2014310480B2 (en) 2020-03-05
KR20160065092A (ko) 2016-06-08
US20160200760A1 (en) 2016-07-14
CA2921883A1 (en) 2015-02-26
CN105683210A (zh) 2016-06-15
CA2921883C (en) 2020-03-24
SG10201801371PA (en) 2018-04-27
CN111875665A (zh) 2020-11-03
US10661264B2 (en) 2020-05-26

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